CN110404910A - Cleaning method, cleaning device and immunity analysis instrument - Google Patents
Cleaning method, cleaning device and immunity analysis instrument Download PDFInfo
- Publication number
- CN110404910A CN110404910A CN201910681463.1A CN201910681463A CN110404910A CN 110404910 A CN110404910 A CN 110404910A CN 201910681463 A CN201910681463 A CN 201910681463A CN 110404910 A CN110404910 A CN 110404910A
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- China
- Prior art keywords
- imbibition
- reactor
- station
- fluid injection
- cleaning
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/28—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
- B08B9/30—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking and having conveyors
- B08B9/32—Rotating conveyors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/42—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus being characterised by means for conveying or carrying containers therethrough
- B08B9/44—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus being characterised by means for conveying or carrying containers therethrough the means being for loading or unloading the apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
Abstract
A kind of cleaning method includes the following steps: in fluid injection station and collects transhipment reactor (30) between station；Cleaning solution is injected into the reactor (30) in the fluid injection station；The magnetic grain conjugate in the reactor (30) is collected to the inner sidewall of the reactor (30) in the collection station, and extracts waste liquid from the reactor (30) for having been injected into cleaning solution in imbibition station；Wherein, the quantity of the fluid injection station is less than the quantity of imbibition station, cleaning solution is injected at least two reactors (30) after same fluid injection station successively elder generation, extracts waste liquid from multiple reactors (30) simultaneously respectively in all imbibition stations.
Description
Technical field
The present invention relates to vitro diagnostic techniques fields, clearly more particularly to a kind of cleaning method, cleaning device and comprising this
The immunity analysis instrument of cleaning device.
Background technique
Luminescence immunoassay is by using enzyme, luminous agent etc. based on the immunological response that antigen-antibody be combined with each other
Optical signal and analyte concentration etc. are associated, analyze analyte in sample and contain by luminescence-producing reaction by mass signatures antigen-antibody
Amount.
During cleaning separation (referred to as cleaning sometimes herein), first with magnetic grain (the usually master of magnetic grain reagent component
Want ingredient) it is that the target analytes in sample are captured and combined by solid phase carrier, then will directly or indirectly it be tied by magnetic force again
Closing has the magnetic grain of target analytes to collect on the inner sidewall of reaction cup, after repeatedly injecting cleaning solution and extracting waste liquid, most
Removal is not associated with free label and other interference impurity on magnetic grain eventually, so as to the antigen-antibody knot being connected on magnetic grain
It closes object (i.e. magnetic grain conjugate) and carries out signal measurement.Or cleaning effect low for traditional cleaning method or cleaning efficiency
Difference, while but also the apparatus structure for executing the cleaning method is complicated and bulky.
Summary of the invention
The technical problem that the present invention solves is how to simplify device and the raising for implementing the cleaning method in structure
Cleaning efficiency.
A kind of cleaning method, includes the following steps:
Reactor is transported between fluid injection station and collection station；
Cleaning solution is injected into the reactor in the fluid injection station；
The magnetic grain conjugate in the reactor is collected to the inner sidewall of the reactor in the collection station, and
Waste liquid is extracted from the reactor for having been injected into cleaning solution in imbibition station；
Wherein, the quantity of the fluid injection station is less than the quantity of the imbibition station, successively successive in same fluid injection station
Cleaning solution is injected at least two reactors, in all imbibition stations respectively while from multiple reactors
Extract waste liquid.
Since the quantity of fluid injection station is less than the quantity of the imbibition station, so that corresponding with imbibition station and clear for infusing
The number of components of washing lotion is reduced, then simplified and the optimal enforcement cleaning method the device in structure and component, it is ensured that is implemented
The device volume of the cleaning method is small and reduces manufacturing cost；To at least two reactions after same fluid injection station successively elder generation
Cleaning solution is injected in device, it is ensured that the accuracy and repeatability of fluid injection improve cleaning effect.In addition, multiple imbibition parts can be same
When waste liquid is extracted from multiple reactors, the cleaning efficiency of cleaning device can be improved in this way.
A kind of cleaning device, comprising:
Component is transported, including for carrying reactor and rotatable turntable, the turntable has been provided at circumferentially spaced along it
Multiple carrying positions for being used to carry reactor；
Fluid injection component, including the fluid injection part for injecting cleaning solution into reactor；
Imbibition component, including the imbibition part for extracting waste liquid to the reactor for having been injected into cleaning solution；And
Component, including magnetic part are captured, the magnetic part is used to collect the magnetic grain conjugate in reactor in reactor
On inner sidewall；
Wherein, the quantity of the fluid injection part is less than the quantity of the imbibition part, and the turntable carries the reactor in institute
It states and is rotated between both imbibition part and the fluid injection part present position.
Since the quantity of fluid injection part is less than the quantity of the imbibition part, reduced so that the total quantity of fluid injection part is opposite, thus
The quantity for the other fluid devices connecting with each fluid injection part is reduced, then simplify and optimizes cleaning device overall structure, and is dropped
Low overall volume and manufacturing cost are conducive to the Miniaturization Design of cleaning device；Fluid injection part is less than imbibition part, but also on turntable
To carrying position is corresponding corresponding to fluid injection part simplifies, and then reduce the volume of turntable, similarly help to the miniaturization of cleaning device
Design.In addition, multiple imbibition parts can extract waste liquid from multiple reactors simultaneously, the cleaning efficiency of cleaning device is improved in this way.
A kind of immunity analysis instrument, including above-mentioned cleaning device.
Detailed description of the invention
Fig. 1 is the integral installation distribution structure schematic diagram for the cleaning device that an embodiment provides；
Fig. 2 is structural schematic diagram of the Fig. 1 under another visual angle；
Fig. 3 is the structural schematic diagram that bracket drives after the rising of imbibition part in Fig. 1；
Fig. 4 is that the partial structural diagram after fluid injection component and signal part is removed in Fig. 1；
Fig. 5 is that the partial structural diagram after part imbibition component is removed in Fig. 4；
Fig. 6 is the partial structural diagram that component is mixed in Fig. 1；
Fig. 7 is the flow diagram for the cleaning method that an embodiment provides.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
Add thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.Term as used herein "inner", "outside", "left", "right" and
Similar statement for illustrative purposes only, is not meant to be the only embodiment.
Homomixture in reactor before entering cleaning separation is referred to as reactant by the present invention, and reactant is usually to be measured
Conjugate etc. after mixed reactant or sample and the reagent reaction of sample and reagent；Will cleaning separation process in Xiang Fanying
The cleaning buffer solution (Wash buffer) injected in device is referred to as cleaning solution, and cleaning buffer solution is injected into reactor and is referred to as
Fluid injection；The mixture injected in the reactor after cleaning solution is referred to as waste liquid, waste liquid can be by the mixed of reactant and cleaning solution
The material compositions such as the mixture of immune complex and cleaning solution after closing object, reaction and the unbonded ingredient not cleaned up.
Those skilled in the art is appreciated that keep cleaning separation more thorough, must be reduced after cleaning separates to greatest extent in reactant
The residual of unbonded ingredient, cleaning, which separates, to be generally comprised repeatedly note cleaning solution and extracts useless in the reactor after injecting cleaning solution
First time injection cleaning solution, the waste liquid collecting magnetic grain conjugate and extracting after injection cleaning solution cleaning are defined as the first rank by liquid
It cleans, second of injection cleaning solution, collection magnetic grain conjugate and absorption waste liquid is defined as second-order cleaning ... and inject n-th
Cleaning solution, collection magnetic grain conjugate and absorption waste liquid are defined as the cleaning of N rank.Cleaning separation generally includes the cleaning of 2-6 rank every time.
It is clear inject for the first time for the reactant that will carry out cleaning in isolated reactor in some immunity analysis instruments
Before washing lotion, there are one the process for collecting magnetic grain conjugate and the unbonded reactant in preparatory abstraction reaction device in advance, this hairs
It is bright in order to describe conveniently, by the process of the unbonded reactant of unimplanted cleaning solution in the secondary abstraction reaction device be defined as cleaning
Pre- imbibition, pre- imbibition disregard calculation in the N rank clean range of cleaning, imbibition of the invention or draw waste liquid, except non-specifically saying
It is bright, refer in particular to the absorption to the waste liquid in the reactor after injection cleaning solution.Each test item is according to the difference of reaction method, such as
One-step method, two-step method, three-step approach can correspond in entire reaction process and carry out 1-3 cleaning separation, and cleaning includes 2-6 every time
Rank cleaning.
Simultaneously refering to fig. 1 to Fig. 5, the immunity analysis instrument that one embodiment of the invention provides includes cleaning device 10, the cleaning
Device 10 is used to clean the magnetic grain conjugate inside reactor 30, which includes transhipment component 100, fluid injection component
200, imbibition component 300, capture component 400, mixing component 500 and signal part 600, fluid injection component 200 therein and imbibition group
Both parts 300 can form a washing separator structure 20.
In some embodiments, transhipment component 100 includes for carrying reactor 30 and rotatable turntable 110.In addition,
Transporting component 100 further includes shaft 120, axle sleeve 140, bearing and the second driver 130, and the second driver 130 is fixed on imbibition
On the lower surface of the bottom plate 320 of component 300, the second driver 130 can be stepper motor etc..The lower end of shaft 120 and second
The output axis connection of driver 130, the upper end of shaft 120 passes through bottom plate 320 and the upper surface of opposed bottom 320 extends upwards.
Turntable 110 is disc-shaped structure, is fixed on the upper end of shaft 120, when the rotation of 130 drive shaft 120 of the second driver, shaft
120 will drive turntable 110 to do intermittence rotation.Axle sleeve 140 is fixed between bottom plate 320 and turntable 110, when the second driver
When 130 work, axle sleeve 140 remain stationary motionless state.Bearing is set in axle sleeve 140, and shaft 120 and bearing fit pass through
Bearing is set, it is possible to reduce the frictional force in 120 rotary course of shaft, and improve the rotation essence of both shaft 120 and turntable 110
Degree.
Turntable 110 is provided at circumferentially spaced multiple carrying positions along it, for carrying reactor 30.Carrying position can be any suitable
Close the structure, such as hole, slot, bracket etc. of carrying reactor 30.In one embodiment, carrying position is through hole 111, through hole
111 run through the upper and lower surfaces of turntable 110.Circumferentially-spaced arrangement of multiple through holes 111 along turntable 110, through hole 111
Quantity is at least 5.It specifically, can be 8,10,12 etc..Through hole 111 can be circular stepped hole, stepped hole
It is made of the macropore and aperture being coaxially disposed, the diameter of macropore is greater than the diameter of aperture, and the bottom wall of macropore forms entire stepped hole
Step surface.Reactor 30 is generally cylindrical, and bulge loop 31 is provided on the lateral circle surface of reactor 30, and the bulge loop 31 is along reactor
30 diametrically lateral circle surface extends the length of setting, when reactor 30 is threaded through in the through hole 111, on reactor 30
Bulge loop 31 will be abutted against with the step surface on stepped hole, prevent reactor 30 from falling from through hole 111, therefore through hole 111 rises
To the carrying effect to reactor 30, each through hole 111 can be formed on turntable 110 for carrying the carrying of reactor 30
Position 111a.When turntable 110 drives turntable 110 to move, the reactor 30 in through hole 111 will follow turntable 110 around the shaft 120
Rotation.
In some embodiments, imbibition component 300 includes imbibition part 310, bottom plate 320, bracket 340 and the first driver
330.Imbibition part 310 is mounted on bracket 340, and the first driver 330 is arranged on bottom plate 320 and connect with bracket 340, first
Driver 330 moves up and down for driving arm 340, so that imbibition part 310 is stretched out or exited in reactor 30.
Imbibition part 310 is used to extract waste liquid to the reactor 30 for having been injected into cleaning solution.As it was noted above, imbibition part herein
310 refer in particular to extract waste liquid to the reactor 30 for having been injected into cleaning solution, do not include aspirating in advance to the reactant in reactor 30
Pre- imbibition part.Imbibition part 310 can be elongated aspirating needle, other can also be suitble to the structure of pumping liquid for pipette etc.
Deng.Imbibition part 310 is corresponding with the carrying position 111a on turntable 110, for example, orthographic projection of the imbibition part 310 on turntable 110 can be with
It falls on carrying position 111a, absolute position locating for imbibition part 310 is the imbibition station that waste liquid is extracted from reactor 30.It is aobvious
And be clear to, imbibition part 310 and imbibition station correspond, and the two quantity is identical.Bracket 340 includes lapping plate 341, push plate
342 and support plate 343, support plate 343 is horizontally disposed and is located at the top of turntable 110, in the axial direction of shaft 120, support plate
343 are spaced between the two with turntable 110 and keep reasonable spacing.Imbibition part 310 can be fixed in support plate 343.Imbibition
The quantity N (N=2,3,4,5,6,7) of part 310 is equal with the cleaning order N of reactor 30.For example, cleaning needs reactor 30 every time
3 rank cleanings are carried out, then the quantity of imbibition part 310 is 3, and three imbibition parts 310 are denoted as the first imbibition part (or the first rank respectively
Imbibition part), the second imbibition part (or second-order imbibition part) and third imbibition part (or third rank imbibition part)；Reactor 30 is clear every time
It washes and needs to carry out 4 rank cleanings, then the quantity of imbibition part 310 is 4, and four imbibition parts 310 are denoted as the first imbibition part (or the respectively
Single order imbibition part), the second imbibition part (or second-order imbibition part), third imbibition part (or third rank imbibition part) and the 4th imbibition part
(or fourth order imbibition part).The quantity of the imbibition corresponding with its of imbibition part 310 position can be for two or greater than four etc..Push plate
342 are vertically arranged, and close to bottom plate 320, laterally setting, the upper end of push plate 342 are connect lapping plate 341 with support plate 343, pushing tow
The lower end of plate 342 is connect with lapping plate 341.
First driver 330 includes lead screw motor 331 and the first guide rod 332, and the first guide rod 332 is vertically arranged and its lower end
It is fixed on bottom plate 320, the upper end of the first guide rod 332 is free end, and the first guide rod 332 is threaded through in lapping plate 341, thus real
Existing lapping plate 341 being slidably connected between the two with the first guide rod 332.Bit-avoiding slot 342a is offered in push plate 342, this keeps away position
Slot 342a is axially extending along shaft 120, and in brief, i.e. bit-avoiding slot 342a extends along the vertical direction, lead screw motor 331
Screw axis 331a and lapping plate 341 are rotatablely connected, meanwhile, screw axis 331a is located in bit-avoiding slot 342a and can be with respect to bit-avoiding slot
342a movement, therefore bit-avoiding slot 342a is provided for the movement of screw axis 331a and is kept away bit space well.For example, working as lead screw motor
When 331 screw axis 331a is rotated clockwise, the rotary motion of screw axis 331a is converted into lapping plate 341 with respect to the first guide rod
332 upward slidings, meanwhile, lapping plate 341 drives push plate 342 and support plate 343 to move upwards, so that imbibition part
310 follow support plate 343 to move upwards to exit in reactor 30.When the screw axis 331a of lead screw motor 331 is rotated counterclockwise
When, the rotary motion of screw axis 331a is converted into lapping plate 341 with respect to 332 downward sliding of the first guide rod, meanwhile, lapping plate
341 drive push plate 342 and support plate 343 move downward so that imbibition part 310 follow support plate 343 to move downward with
It protrudes into reactor 30 and extracts waste liquid.
Fluid injection component, for injecting cleaning solution into reactor.In some embodiments, fluid injection component 200 includes fluid injection
Part 210 and loading plate 220, loading plate 220 is horizontally disposed and is located at the top of turntable 110, in the axial direction of shaft 120, carrying
Plate 220 and turntable 110 are spaced between the two and keep reasonable spacing.Loading plate 220 can be fixed with respect to the position of turntable 110
Motionless, certainly, loading plate 220 can also be connect with the bracket 340 of imbibition component 300, by the up and down motion of bracket 340 with band
Dynamic loading plate 220 moves up and down.Fluid injection part 210 is fixed on loading plate 220, can is elongated injection needle, can also be used
Liquid injection pipe or fluid injection spray orifice etc. can inject the component substitution of liquid.111a pairs of carrying position on fluid injection part 210 and turntable 110
It answers, for example, the fluid injection part of fluid injection part 210 can be fallen on carrying position 111a in the orthographic projection on turntable 110, fluid injection part 210
Locating absolute position is the fluid injection station that cleaning solution is injected into reactor 30.The quantity of fluid injection part 210 can be one,
Two, certainly, the quantity of fluid injection part 210 can also be greater than two.It should be strongly noted that corresponding to the same fluid injection work
Position, no matter in corresponding how many fluid injection of the fluid injection part outlet of the fluid injection station, no matter also the fluid injection part includes several needles, pipe
All provide that fluid injection number of packages amount is one Deng, the present invention, i.e., each corresponding fluid injection part of fluid injection station.Multiple fluid injection part correspondences are more
A station, such as the corresponding two fluid injection parts of two fluid injection stations.When fluid injection part 210 injects clearly in fluid injection station into reactor 30
After washing lotion, cleaning solution will clean the magnetic grain conjugate in reactor 30, be not associated with the free mark on magnetic grain with removal
Remember object and other interference impurity.
Component 400 is captured, for collecting the magnetic grain conjugate in the reactor to the reaction before every rank imbibition
On the inner sidewall of device.In some embodiments, capturing component 400 includes magnetic part 420 and mounting rack 410, and mounting rack 410 can be with
Substantially in the form of annular discs, mounting rack 410 is fixed on the axle sleeve 140 of transhipment component 100, is provided with accepting hole on mounting rack 410
411, accepting hole 411 is provided on the lateral circle surface of mounting rack 410, and a part of 411 outside circumference of accepting hole is along mounting rack 410
Radial depressions set depth is formed.The quantity of accepting hole 411 be it is multiple, multiple accepting holes 411 can be with along the axis of mounting rack 410
Uniform intervals arrangement.Magnetic part 420 can be natural permanent magnet or electromagnet etc., the shape phase of magnetic part 420 and accepting hole 411
It is adapted to and is accommodated in the accepting hole 411, the outer surface of magnetic part 420 can be concordant with the lateral circle surface of mounting rack 410.Accepting hole
411, the location of magnetic part 420 is collects station, for closing the magnetic burl in the reactor 30 before every rank imbibition
Object is collected to the inner sidewall of the reactor 30.When turntable 110, which drives reactor 30 to be located at, collects station, reactor 30 will
Within the scope of the magnetic force of magnetic part 420, under the effect of the magnetic attraction caused by magnetic part 420, by the magnetic in reactor 30
Grain conjugate is collected to the inner sidewall of reactor 30.
Collecting station includes imbibition station.In order to avoid the loss of magnetic grain, when every rank imbibition part extracts waste liquid in reactor
Magnetic grain conjugate needs carry out under magnetic-adsorption, thus every rank imbibition station needs to install magnetic part 420, thus imbibition station
It is simultaneously also to collect station, i.e. collection station includes imbibition station.The quantity for collecting station is no less than the quantity of imbibition station.Tool
Body, the collection station of every rank cleaning can be corresponded with imbibition station, can also the corresponding imbibition of multiple collection stations
Station.When the collection station of every rank cleaning and imbibition station correspond, magnetic grain in reactor 30 is completed in the same station
The extraction of waste liquid in the collection of conjugate and reactor；When the corresponding imbibition station of multiple collection stations of every rank cleaning,
Magnetic grain conjugate gradually completes collection in multiple collection stations in reactor 30, imbibition station (while be also the rank cleaning
The last one collects station) continue to collect and complete waste liquid extraction.
The lateral circle surface of mounting rack 410, which is also recessed, is formed with deep gouge 412, and deep gouge 412 extends along the vertical direction, deep gouge 412
The upper surface of mounting rack 410 is run through in upper end, and the lower surface of mounting rack 410, deep gouge 412 and fluid injection part are run through in the lower end of deep gouge 412
The location of 210 (i.e. fluid injection station) is corresponding.
In some embodiments, mixing component 500 includes connecting plate 510, driving motor 520, drive shaft 530 and carrying
Cylinder 540.Connecting plate 510 is laterally arranged, and is additionally provided with the second guide rod 550, the second guide rod 550 on the bottom plate 320 of imbibition component 300
It is vertically arranged and one end of which is fixed on bottom plate 320 and being threaded through in connecting plate 510, another section of company of passing through of the second guide rod 550
Fishplate bar 510 and form free end so that the second guide rod 550 is slidably connected with connecting plate 510, connecting plate 510 can be along the second guide rod
550 slide up and down.Driving motor 520 is placed on bottom plate 320 and is fixedly connected with connecting plate 510, driving motor 520 and bottom plate
Both 320 do not form a fixed connection relationship, and driving motor 520 is carried on bottom plate 320 or driving motor 520
It is moved upwards far from bottom plate 320.During lead screw motor 331 drives lapping plate 341 to rise along the first guide rod 332, overlap joint
Plate 341 will be abutted against with connecting plate 510, and when lapping plate 341 continues to rise, lapping plate 341 is by bearer connection plate 510 and drives
Motor 520 rises along the second guide rod 550 together.In the mistake that lead screw motor 331 drives lapping plate 341 to decline along the first guide rod 332
Cheng Zhong, lapping plate 341 will be abutted against with connecting plate 510 to form supporting role, connecting plate 510 and driving electricity to connecting plate 510
Machine 520 is moved downward along the second guide rod 550 under gravity, when driving motor 520 is in contact with bottom plate 320, the bottom of at
Under the position-limiting action of plate 320, connecting plate 510 and the stopping of driving motor 520 are moved downward, at this point, lead screw motor 331 can also band
Dynamic lapping plate 341 continues decline until lapping plate 341 is in contact with bottom plate 320 along the first guide rod 332.341 surface of lapping plate
A part recess forms the first confined planes 341a and the second confined planes 341b of bending connection, such as the first confined planes 341a and the
Two confined planes 341b can be mutually perpendicular to, and when 341 bearer connection plate 510 of lapping plate, connecting plate 510 is with the first confined planes 341a
It being abutted against with the second confined planes 341b, the first confined planes 341a and the second confined planes 341b play position-limiting action to connecting plate 510,
It prevents from entirely mixing component 500 and generates vibration during up and down motion, improve and mix 500 traveling comfort of component.
The lower end of drive shaft 530 and the output axis connection of driving motor 520, bearing tube 540 are fixed on the upper of drive shaft 530
End, drive shaft 530 can be coaxially disposed with bearing tube 540, and driving motor 520 is used to that drive shaft 530 to be driven to rotate, so that
Bearing tube 540 follows drive shaft 530 to rotate.Refering to Fig. 6, is offered on bearing tube 540 and mix hole 541, reactor 30 can be with this
Hole 541 is mixed to cooperate, the central axis and the central axis of drive shaft 530 for mixing hole 541 are parallel to each other, i.e., mixing hole 541 and
Spacing is kept between drive shaft 530 there are certain degree of eccentricity, in reactor 30 and is mixed after hole 541 cooperates, and drive shaft is worked as
When 530 drive bearing tubes 540 rotate, under the action of eccentric force, the suspension in reactor 30 comprising magnetic grain conjugate will be produced
Raw eccentric concussion, so that entire suspension is in and mixes state well.
When needing to mix, under the action of lead screw motor 331,341 pushing tow connecting plate 510 of lapping plate can be driven to rise,
And then increase driving motor 520 and bearing tube 540, meanwhile, the deep gouge 412 opened up on mounting rack 410 can be bearing tube 540
Movement offer keep away bit space, prevent mounting rack 410 to constitute interference to the movement of bearing tube 540, when bearing tube 540 rises to one
When determining height and cooperating with reactor 30, lead screw motor 331 stops working.At this point, driving motor 520 passes through 530 band of drive shaft
Dynamic bearing tube 540 generates eccentric oscillation, so that the cleaning solution in reactor 30 forms turbulent flow, under the action of turbulent flow, cleaning solution
Object will be closed to magnetic burl and generates effectively cleaning, so that removal is not associated with free label on magnetic grain and other dry as far as possible
Disturbing matter；Furthermore magnetic grain conjugate is enabled to be evenly dispersed in cleaning solution.When the suspension in reactor 30 has mixed
Bi Hou, lead screw motor 331 drive lapping plate 341 to move downward, and then make entirely to mix component 500 and move downward, and finally make
The bottom of reactor 30 completely disengages the mixing hole 541 on bearing tube 540, i.e. reactor 30 exits completely from mixing hole 541；
When turntable 110 needs that reactor 30 is driven to be transferred to imbibition station from the fluid injection station, the bearing tube of reactor 30 is had disengaged from
540 will not generate interference to the rotation of reactor 30, to realize that reactor 30 is smooth from fluid injection station to imbibition station
Transfer.
The quantity of fluid injection part 210 is less than the quantity of imbibition part 310.For example, the quantity of imbibition part 310 is three, fluid injection part
210 quantity is one, corresponding, and the quantity of imbibition station is three, and the quantity of fluid injection station is one；Imbibition part 310
Quantity is four, and the quantity of fluid injection part 210 is two, and certainly, the quantity of imbibition station is four, and the quantity of fluid injection station is two
It is a.Compared with the design equal with 210 quantity of fluid injection part with traditional imbibition part 310, the quantity of fluid injection part 210 in above-described embodiment
Less than the quantity of imbibition part 310, reduces so that the total quantity of fluid injection part 210 is opposite, connect to reduce with each fluid injection part 210
Transfer tube and the fluid devices such as solenoid valve quantity, to be conducive to reduce the whole knot of cleaning device 10 and immunity analysis instrument
Structure, and the volume and manufacturing cost of the two are reduced, be conducive to the Miniaturization Design of cleaning device 10 and immunity analysis instrument；Also,
The reduction of fluid injection part 210, but also on turntable 110 to carrying position 111a is corresponding corresponding to fluid injection part 210 reduces, and then reduce
The volume of turntable 110 similarly helps to the Miniaturization Design of cleaning device 10 and immunity analysis instrument.Meanwhile multiple imbibition parts 310
Waste liquid can be extracted from multiple reactors 30 simultaneously, reduce total scavenging period of magnetic grain conjugate in this way, to improve cleaning
The cleaning efficiency of device 10 and immunity analysis instrument.
Signal part 600, for the Injection Signal reagent into the reactor 30 for completing cleaning.In some embodiments, signal
Part 600 is located on the loading plate 220 of fluid injection component 200, and signal part 600 can be elongated acicular texture.Signal part 600, note
Liquid part 210 and 310 three of imbibition part respectively correspond carrying position 111a different on turntable 110, absolute where signal part 600
Position is that signal injects station, and signal part 600 injects station Injection Signal reagent into the reactor 30 for completing cleaning in signal,
So as to the subsequent measurement for carrying out optical signal to magnetic grain conjugate.
Reactor 30 after the completion of moving into and clean for the reactor 30 that will need to clean removes transhipment component 100, turns
Transfer position is also set up on fortune component 100, transhipment component 100 can be by reactor 30 in transfer position, fluid injection station and imbibition position station
Between transport.
One due to the waste liquid in note cleaning solution in cleaning separation process and the reactor after extraction injection cleaning solution is a pair of
It should be related to, it is the general technology implementation of this field that imbibition part 310 is equal with 210 quantity of fluid injection part.Fluid injection part 210 of the present invention
Quantity be less than the quantity of imbibition part 310, need special process and method to cooperate to realize.
Simultaneously refering to fig. 1 and Fig. 7 is by above-mentioned cleaning device 10 and immunity analysis instrument can form following cleaning method,
The cleaning method can be implemented in i.e. above-mentioned cleaning device 10 and immunity analysis instrument.By taking reactor completes wherein single order cleaning as an example,
The cleaning method mainly includes the following steps:
S710 in fluid injection station and collects transhipment reactor 30 between station；
S720 injects cleaning solution into reactor 30 in fluid injection station；
S730 collects the magnetic grain conjugate of the suspension in reactor 30 to the inner sidewall of reactor 30 in collecting station
On, and waste liquid is extracted from the reactor 30 for having been injected into cleaning solution in imbibition station；
Wherein, the quantity of fluid injection station is less than the quantity of imbibition station, at least two after same fluid injection station successively elder generation
Cleaning solution is injected in a reactor 30, extracts waste liquid from multiple reactors 30 simultaneously respectively in whole imbibition stations.
In some embodiments, the circumferentially-spaced row of the same circumference by fluid injection station and imbibition station on turntable 110
Column make turntable 110 that reactor 30 be driven to move in a circle between fluid injection station and imbibition station.The quantity of imbibition station is equal to
Reactor 30 cleans the cleaning order once cleaned.The quantity of fluid injection station can be one, and the quantity of imbibition station is three,
Three imbibition stations are denoted as the first imbibition station, the second imbibition station and third imbibition station respectively, and the first imbibition part 310 is located at
First imbibition station, the second imbibition part 310 are located at the second imbibition station, and third imbibition part 310 is located at third imbibition station；Fluid injection
The quantity of station can be two, and fluid injection station is denoted as the first fluid injection station, the second fluid injection station, the quantity of imbibition station respectively
It is four, four imbibition stations are denoted as the first imbibition station, the second imbibition station, third imbibition station and the 4th imbibition work respectively
Position, the first imbibition part 310 are located at the first imbibition station, and the second imbibition part 310 is located at the second imbibition station, third imbibition part 310
Positioned at third imbibition station, the 4th imbibition part 310 is located at the 4th imbibition station.
For single same reactor 30, to ensure to have good cleaning effect, a complete cleaning process packet
The cleaning of at least three ranks is included, i.e., inject cleaning solution three times and extracts waste liquid, is reacted below with the situation for carrying out three rank cleanings single
The cleaning of device 30 is illustrated:
Reactor 30 is moved into turntable 110 by the first step, can carry out pre-collecting and pre- imbibition to reactor 30, i.e., first
By the unbonded reactant suction in reactor 30, so that only remaining magnetic grain conjugate and not cleaned up residual in reactor 30
Object is stayed, the reactor 30 that then turntable 110 is only contained with magnetic grain conjugate turns to fluid injection station.It is of course also possible to not to anti-
Device 30 is answered to carry out pre-collecting and pre- imbibition, and by 30 cross-docking of reactor containing reactant to fluid injection station.Work as reactor
When 30 arrivals to fluid injection station, it is clear to carry out to magnetic grain conjugate to inject cleaning solution into reactor 30 by fluid injection part 210
It washes, free label and other interference impurity on magnetic grain is not associated with removal.The first rank fluid injection is carried out into reactor 30
When or fluid injection after, the suspension in reactor 30 containing magnetic grain conjugate can be mixed, can not also be mixed.When mixing, make
It mixes component 500 to move upwards, so that the mixing hole 541 on reactor 30 and bearing tube 540 cooperates, driving motor 520 passes through
Drive shaft 530 drives bearing tube 540 to rotate, and the suspension in reactor 30 generates eccentric oscillation and mixes, and magnetic grain conjugate is equal
Even to be suspended in cleaning solution, during eccentric vibrating, cleaning solution forms good cleaning effect to magnetic grain conjugate.It mixes
After, it mixes component 500 and moves downward, reactor 30 completely disengages the mixing hole 541 on bearing tube 540, so as to turntable 110
Reactor 30 is driven to leave the fluid injection station.So far, injection cleaning solution for the first time is completed in reactor 30, that is, completes the first rank note
Enter cleaning solution.
The reactor 30 for injecting cleaning solution is transferred to from fluid injection station and collects station or the first suction by second step, turntable 110
Liquid station, when reactor 30, which is located at, collects station, magnetic grain conjugate is gradually collected by magnetic part 420 to the inside of reactor 30
On wall.When the magnetic grain conjugate in reactor 30, which is collected, to be completed, reactor 30 is located at the first imbibition station.Collect station and the
Equal one imbibition station is when being overlapped, and turntable 110 does not rotate, and when collecting station more than imbibition station, turntable is rotated reactor
30 are transported to the first imbibition station.331 driving arm 340 of lead screw motor drives support plate 343 to move downward, so that imbibition part
310 follow support plate 343 to move downward to stretch in reactor 30, because magnetic burl closes in 310 abstraction reaction device 30 of imbibition part
Whole waste liquids of object cleaning and formation, so that the residue for being only left magnetic grain conjugate in reactor 30 and not cleaning up.Instead
Answer device 30 extract waste liquid after, 331 driving arm 340 of lead screw motor drive support plate 343 move upwards, imbibition part 310 with
It moves upwards with support plate 343 to be exited from reactor 30, so that turntable 110 drives reactor 30 to leave the imbibition station.
So far, reactor 30 is completed extracts waste liquid for the first time, that is, completes the first rank and extract waste liquid.
Third step, turntable 110 drive reactor 30 to be transported to fluid injection station from imbibition station, when reactor 30 is arrived to note
When liquid station, the relevant operation in the above-mentioned first step is repeated.So far, second of injection cleaning solution is completed in reactor 30, i.e., complete
Cleaning solution is injected at second-order.It is mixed when reactor 30 carries out second-order injection cleaning solution or usually afterwards.
4th step, turntable 110 drives reactor 30 to be transferred to from fluid injection station and collects station or the second imbibition station, when anti-
When answering the arrival of device 30 to imbibition station, the relevant operation in above-mentioned second step is repeated.So far, second of pumping is completed in reactor 30
Waste liquid is taken, that is, completes the second order and extracts waste liquid.
5th step, turntable 110 drive reactor 30 to be transferred to fluid injection station from imbibition station, when reactor 30 is arrived to note
When liquid station, the relevant operation in the above-mentioned first step is repeated.So far, third time injection cleaning solution is completed in reactor 30, i.e.,
It completes third rank and injects cleaning solution.It is mixed when reactor 30 carries out third rank injection cleaning solution or usually afterwards.
6th step, turntable 110 drives reactor 30 to be transferred to from fluid injection station and collects station or third imbibition station, when anti-
When answering the arrival of device 30 to imbibition station, the relevant operation in above-mentioned second step is repeated.So far, third time is completed in reactor 30
Waste liquid is extracted, i.e. completion third rank extracts waste liquid.
For single same reactor 30, after completing primary complete cleaning process, i.e., same reactor 30 is completed
After collecting magnetic grain conjugate and extracting waste liquid, signal reagent is added in Xiang Suoshu reactor 30 in the injection cleaning solution of whole orders,
So as to the subsequent measurement for carrying out optical signal to magnetic grain conjugate.In one embodiment, turntable 110 drives reactor 30 from imbibition
Station is transferred to signal injection station, and when reactor 30, which is arrived at, injects station to signal, letter is added in Xiang Suoshu reactor 30
Number reagent.The reactor 30 that signal reagent is added finally is removed into turntable 110.Certainly, it can also will complete cleaning and only be contained with magnetic
The reactor 30 of grain conjugate directly removes turntable 110, and the filling of signal reagent is completed outside turntable 110.
It, still can be according to aforesaid operations mode to single same reactor 30 when needing to carry out the cleaning of three ranks or more
Carry out the cleaning of three ranks or more.
For single same reactor 30, the cleaning solution of injection at least twice of the same reactor 30 is in identical fluid injection
Station is completed.When fluid injection station is two, for example, in the case where injecting the total degree of cleaning solution is three times, two of them
The injection cleaning solution of order wherein complete by a fluid injection station, another order injects cleaning solution in another fluid injection work
It completes position.When fluid injection station is only one, i.e., fluid injection part 210 is only one, the fluid injection of all orders of same reactor 30 is clear
Washing lotion is completed in the fluid injection station, for example, the injection of the first order is clear in the case where injecting the total degree of cleaning solution is three times
Washing lotion, the second order injection cleaning solution and third order injection cleaning solution are completed in the fluid injection station.
For single same reactor 30, the imbibition of different orders is completed respectively at different imbibition stations.For example, taking out
When the total degree of waste liquid being taken to be three times, the total quantity of imbibition station is similarly three, passes through the first imbibition in the first imbibition station
Part completes the first order and extracts waste liquid, completes the second order by the second imbibition part in the second imbibition station and extracts waste liquid, the
Three imbibition stations complete third order by third imbibition part and extract waste liquid.
In some embodiments, multiple reactors 30 on turntable 110 can be cleaned simultaneously, is infused below with one
The situation that liquid station, multiple reactors 30 carry out three rank cleanings is illustrated:
The first step, turntable 110 first are transported, and first reactor is transported to fluid injection station, and fluid injection part 210 is to the reaction
Cleaning solution is injected in device.
Second step, turntable 110 second are transported, and second reactor is transported to fluid injection station, fluid injection part 210 to this second
Cleaning solution is injected in a reactor.
Third reactor is transported to fluid injection station by third step, the transhipment of 110 third of turntable, and fluid injection part 210 is to the third
Cleaning solution is injected in a reactor.
4th step, turntable 110 the 4th are transported, and first reactor, second reactor and third reactor are transported
To different collection station or imbibition station, three imbibition parts 310 are simultaneously in different imbibition stations respectively to three reactors
30 carry out extraction waste liquid.For example, the first imbibition part extracts waste liquid to first reactor, the second imbibition part is to second reactor
Waste liquid is extracted, third imbibition part extracts waste liquid, and the first imbibition part, the second imbibition part and third imbibition to third reactor
Part extracts waste liquid simultaneously.
5th step, is constantly transferred to fluid injection station for reactor 30, and the above-mentioned first step of repetition, will to the operation of the 4th step
The reactor 30 for completing whole order cleanings removes turntable 110 successively.
In some embodiments, the order that multiple reactors 30 extract waste liquid in whole imbibition stations simultaneously is different.
Such as imbibition station be three when, be denoted as the first imbibition station, the second imbibition station and third imbibition station respectively, be located at first
Reactor 30 at imbibition station extracts waste liquid just at the first order, and the reactor 30 at the second imbibition station is just
Waste liquid is extracted in the second order, the reactor 30 at third imbibition station extracts waste liquid just at third order.By
Imbibition part 310 at multiple imbibition stations can carry out extraction waste liquid simultaneously, can save the waiting time between each reactor 30,
To improve cleaning efficiency.
In some embodiments, it when every rank is cleaned, transports at least twice, at least two reactors 30 is successively transported to phase
Same fluid injection station carries out the fluid injection of different orders.At least two reactors 30 are successively successively completed not in identical fluid injection station
With the injection cleaning solution of order.For example, first reactor be after fluid injection station completes the first order injection cleaning solution, then the
Two reactors complete the second order in the fluid injection station and inject cleaning solution, complete in the fluid injection station followed by third reactor
Cleaning solution is injected at third order.
Cleaning method of the invention, the N number of reactor for needing N rank to clean complete different orders in N number of imbibition station parallel
Imbibition, wherein at least two reactor successively successively completes the injection cleaning solution of different orders in identical fluid injection station, no
Only improve the imbibition efficiency of cleaning, also effectively reduce fluid injection realization structural volume and cost, reduce fluid injection station and
The quantity of fluid injection part and the size for reducing transhipment disk, on the other hand decrease the difference of not same order reservoir quantity accuracy,
To be conducive to the realization of compact-sized, testing efficiency is high, performance is good cleaning device and immunity analysis instrument.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (16)
1. a kind of cleaning method, which comprises the steps of:
Reactor is transported between fluid injection station and collection station；
Cleaning solution is injected into the reactor in the fluid injection station；
The magnetic grain conjugate in the reactor is collected to the inner sidewall of the reactor in the collection station, and in suction
Liquid station extracts waste liquid from the reactor for having been injected into cleaning solution；
Wherein, the quantity of the fluid injection station is less than the quantity of the imbibition station, to extremely after same fluid injection station successively elder generation
Cleaning solution is injected in few two reactors, is extracted from multiple reactors simultaneously respectively in all imbibition stations
Waste liquid.
2. cleaning method according to claim 1, which is characterized in that for the reactor, cleaning includes at least every time
Carry out three rank cleanings.
3. cleaning method according to claim 1 or 2, which is characterized in that the injection at least twice of the same reactor
Cleaning solution is completed in the identical fluid injection station.
4. cleaning method according to claim 2, which is characterized in that the same reactor is complete in different imbibition stations
It is equal to the total quantity of the imbibition station at the imbibition of different orders and imbibition order.
5. cleaning method according to claim 2, which is characterized in that multiple reactors are simultaneously in all imbibitions
The order that station carries out imbibition is different.
6. cleaning method according to claim 2, which is characterized in that at least two reactors are in the identical note
Liquid station successively successively completes the injection cleaning solution of different orders.
7. cleaning method according to claim 2, which is characterized in that when every rank is cleaned, exists and transport at least twice, it is near
Few two reactors are successively transported to the injection cleaning solution that identical fluid injection station carries out different orders.
8. according to claim 1 to cleaning method described in any one of 2,4 to 7, which is characterized in that the number of the fluid injection station
Amount is one, and the quantity of the imbibition station is three；Or the quantity of the fluid injection station is two, the imbibition station
Quantity is four.
9. a kind of cleaning device characterized by comprising
Component is transported, including for carrying reactor and rotatable turntable, the turntable has been provided at circumferentially spaced multiple along it
For carrying the carrying position of reactor；
Fluid injection component, including the fluid injection part for injecting cleaning solution into reactor；
Imbibition component, including the imbibition part for extracting waste liquid to the reactor for having been injected into cleaning solution；And
Component, including magnetic part are captured, the magnetic part is used to collect the magnetic grain conjugate in reactor on the inside of reactor
On wall；
Wherein, the quantity of the fluid injection part is less than the quantity of the imbibition part, and the turntable carries the reactor in the suction
Both liquid part and the fluid injection part rotate between present position.
10. cleaning device according to claim 9, which is characterized in that the quantity of the imbibition part is three, the fluid injection
The quantity of part is one；Or the quantity of the imbibition part is four, the quantity of the fluid injection part is two.
11. cleaning device according to claim 9, which is characterized in that the capture component further includes between the turntable
Accepting hole, the magnetic part accommodating are offered at the mounting rack of setting, mounting rack position corresponding with the imbibition part
In the accepting hole.
12. cleaning device according to claim 9, which is characterized in that further include mixing component, the mixing component includes
Drive shaft and bearing tube with driving axis connection, the mixing hole that can cooperate with the reactor is offered on the bearing tube,
The central axis for mixing hole and the central axis of the drive shaft are parallel to each other.
13. cleaning device according to claim 9, which is characterized in that the imbibition component further includes bottom plate, bracket and
One driver, imbibition part installation on the bracket, first driver be arranged on the bottom plate and with the institute
State bracket connection, first driver for drive the support motion, so that the imbibition part protrude into or exit it is described anti-
Answer device.
14. cleaning device according to claim 13, which is characterized in that further include the mixing component with connecting plate, institute
It states and is provided with guide rod on bottom plate, the mixing component is slidably connected with the guide rod, and the bracket can push the connecting plate
The entire mixing component is driven to slide with respect to guide rod so that the mixing component and the reactor cooperate.
15. cleaning device according to claim 9, which is characterized in that the transhipment component further includes shaft, axle sleeve, axis
It holds and is arranged in the axle sleeve with the second driver, the bearing, the shaft is matched to merge with the axle sleeve and be connected with the turntable
It connects, the axle sleeve is fixed between the imbibition component and the turntable, and second driver is fixed on the imbibition component
It goes up and is used to that the shaft to be driven to rotate.
16. a kind of immunity analysis instrument, which is characterized in that including cleaning device described in any one of claim 9 to 15.
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| CN201910681463.1A CN110404910B (en) | 2019-07-26 | 2019-07-26 | Cleaning method, cleaning device and immunoassay analyzer |
| CN202010682610.XA CN112296049B (en) | 2019-07-26 | 2019-07-26 | Cleaning method |
| CN202010680698.1A CN112296048A (en) | 2019-07-26 | 2019-07-26 | Cleaning method |
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| CN112222121A (en) * | 2020-10-20 | 2021-01-15 | 武汉生之源生物科技股份有限公司 | Cleaning device and immunoassay appearance of reaction tube |
| CN113567691A (en) * | 2020-04-28 | 2021-10-29 | 深圳迎凯生物科技有限公司 | Incubation device and automatic analysis device |
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| CN114226381A (en) * | 2021-12-17 | 2022-03-25 | 深圳迎凯生物科技有限公司 | Cleaning method |
| CN115121213B (en) * | 2022-07-06 | 2023-11-10 | 江苏洁欧康科技有限公司 | Rotary tandem circulation calcium exchange reaction device and method |
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Also Published As
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| CN112296048A (en) | 2021-02-02 |
| CN112296049B (en) | 2022-04-05 |
| CN112296049A (en) | 2021-02-02 |
| CN110404910B (en) | 2020-10-23 |
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Application publication date: 20191105 Assignee: GUANGDONG FEIPENG BIOLOGICAL Co.,Ltd. Assignor: SHENZHEN YINGKAI BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2021440000017 Denomination of invention: Cleaning method, cleaning device and immune analyzer Granted publication date: 20201023 License type: Common License Record date: 20210120 |
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