CN110146712B - Rotary sampling miniature turntable type full-automatic luminous immunoassay system - Google Patents
Rotary sampling miniature turntable type full-automatic luminous immunoassay system Download PDFInfo
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- 238000005070 sampling Methods 0.000 title claims abstract description 46
- 238000003018 immunoassay Methods 0.000 title claims abstract description 20
- 238000006243 chemical reaction Methods 0.000 claims abstract description 82
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 45
- 238000011534 incubation Methods 0.000 claims abstract description 28
- 238000004140 cleaning Methods 0.000 claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims description 28
- 230000001360 synchronised effect Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 abstract description 14
- 238000012360 testing method Methods 0.000 abstract description 5
- 238000004020 luminiscence type Methods 0.000 description 12
- 239000007788 liquid Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 239000002699 waste material Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 4
- 230000005284 excitation Effects 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000003805 vibration mixing Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
- G01N2035/1093—Cylindrical, e.g. variable radius and angle
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses a rotary sampling miniature turntable type full-automatic luminous immunoassay system which comprises a bottom plate, an incubation plate, a reaction turntable, a reaction cup automatic loading assembly, a reagent bin, a sample bin, a sampling assembly, a cleaning station assembly, a darkroom assembly and a miniature mechanical arm, wherein the reaction turntable is arranged above the incubation plate, a plurality of reaction cup grooves are axially distributed on the reaction turntable, the miniature mechanical arm is arranged among the reaction turntable, the cleaning station assembly and the darkroom assembly, the sample bin is arranged on the bottom plate, and the rotatable reagent bin is arranged on the incubation plate; the sampling needle on the sampling assembly moves in the Z-axis direction and rotates around the sampling assembly to sample, so that the movement stroke of the sampling in the process of adding the reagent in the kit or the sample in the sample test tube into the reaction cup is reduced, the whole flow time is further reduced, and the working efficiency is improved; the reagent bin is coaxially arranged on the incubation tray and is cylindrical with the sample bin, so that the layout space of the whole device is reduced, and the whole device is more compact.
Description
Technical Field
The invention relates to the technical field of biological monitoring and clinical examination equipment, in particular to a rotary sampling miniature turntable type full-automatic luminous immunoassay system.
Background
Chemiluminescence and biochemical luminescence measurements have become very common in recent years, which are often used to determine the content of an unknown component in a sample to be measured, and in the last decade luminescence measurements have also played an important role in the study of gene expression and regulation, chemiluminescence being the light stimulated during chemical reactions, and biochemical luminescence being the light emitted by enzymatic addition during chemical reactions. Compared with other measuring techniques, the chemical and biochemical luminescence measuring technique has the following advantages: extremely high sensitivity, wide dynamic range, and continuously emerging luminescence measurement reagents. Luminescence measurements have a very high sensitivity, which is 105 times higher than the sensitivity of spectral absorption measurement techniques and at least 1000 times higher than fluorescence measurement techniques.
The inventor aims at improving the problems of the prior analyzer and performs patent application (application number CN2011019994. X, a full-disc sample-adding miniature turntable type full-automatic immune luminescence analysis system) which is now authorized.
Aiming at a full-disc sample-adding miniature rotary disc type full-automatic immune luminescence analysis system with the application number of CN201101994. X, the following problems are found in the history operation process:
1. The sampling needle is used for adding reagents in the kit and samples in the sample test tube into the reaction cup through the moving mechanisms in the X-axis direction, the Y-axis direction and the Z-axis direction of the large mechanical arm and the sample adding pump, and at the moment, the moving stroke of the sampling needle in the sample adding process is relatively longer, so that the working time of the whole flow of the whole instrument is increased;
2. The reagent bin and the sample bin are designed to be rectangular, and are independently arranged on the bottom plate of the system, so that the layout space of the whole device is increased, and the whole device is not compact enough.
Disclosure of Invention
The invention aims to provide a rotary sampling miniature turntable type full-automatic luminous immunoassay system, wherein a sampling needle on a sampling assembly samples by moving in the Z-axis direction and rotating around the sampling assembly, so that the movement stroke of the sampling needle for the reagent in a reagent box and a sample in a sample test tube in the process of adding the sample into a reaction cup is reduced, the whole flow time is further reduced, and the working efficiency is improved; the reagent bin is coaxially arranged on the incubation tray and is cylindrical with the sample bin, so that the layout space of the whole device is reduced, and the whole device is more compact.
The aim of the invention can be achieved by the following technical scheme:
The utility model provides a rotatory miniature carousel formula full-automatic luminous immunoassay system of sampling, including the bottom plate, the incubation dish, the reaction carousel, reaction cup automatic loading subassembly, the reagent storehouse, the sample storehouse, sampling subassembly, wash station subassembly, darkroom subassembly and miniature arm, the top coaxial arrangement of incubation dish has around axis pivoted reaction carousel, there are a plurality of reaction cup grooves on the reaction carousel axial distribution, and reaction cup groove part is in the incubation dish, reaction cup automatic loading subassembly is located the incubation dish outside, wash station subassembly and install in the outside of reaction carousel, install darkroom subassembly in the one end of wasing station subassembly, miniature arm installs between reaction carousel, wash station subassembly and darkroom subassembly, a serial communication port, install around axis pivoted sample storehouse on the bottom plate.
The sampling assembly is located between the reaction carousel and the sample bin.
And a rotating reagent bin is coaxially arranged above the incubation tray.
Further, the incubation plate, the reaction turntable, the automatic reaction cup loading assembly, the sampling assembly, the cleaning station assembly, the darkroom assembly and the micro-mechanical arm are all fixedly arranged at the upper end of the bottom plate.
Further, a plurality of reagent placing boxes are axially distributed on the reagent bin, and a plurality of reagent placing holes are formed in the reagent placing boxes.
Further, the sample bin comprises a sample chassis and sample racks, wherein the sample background is rotatably installed on the bottom plate around the axis, the sample racks which are axially distributed are installed on the sample chassis, and the sample tubes are clamped between the sample racks.
Further, the sampling assembly comprises a Z-axis movement mechanism, a rotating mechanism and a sample adding needle, wherein the Z-axis movement mechanism is arranged on the bottom plate, the rotating mechanism is arranged on the Z-axis movement mechanism, the rotating mechanism is provided with the sample adding needle, and the sample adding needle is connected with the sample adding pump through a pipeline.
Further, the Z-axis movement mechanism comprises a Z-axis fixing frame and a Z-axis synchronous belt, wherein the Z-axis fixing frame is fixed on the bottom plate, and the Z-axis synchronous belt is arranged on the Z-axis fixing frame.
Further, rotary mechanism includes swinging boom, rotatory hold-in range, roating seat and guide bar, and the swinging boom is fixed on the Z axle hold-in range, and rotatory hold-in range fixed mounting is on the Z axle mount, and rotatory hold-in range inner gearing is connected with the roating seat, and the guide bar is installed to the roating arm lower extreme, along Z axle direction sliding connection between guide bar and the roating seat, and wherein the application of sample needle is fixed on the swinging boom.
Further, the device also comprises a bar code identification device which is fixedly arranged at the upper end of the bottom plate and is positioned at one side of the sample bin.
The invention has the beneficial effects that:
The invention is further improved on the prior art, on the premise of having the function of the existing luminous immunoassay system (application number CN2011019994. X), the sampling needle samples by moving in the Z-axis direction and rotating around the sampling assembly, so that the movement stroke of the sampling needle for the reagent in the kit and the sample in the sample tube in the process of adding the sample into the reaction cup is reduced, the whole flow time is further reduced, and the working efficiency is improved; the reagent bin is coaxially arranged on the incubation tray and is cylindrical with the sample bin, so that the layout space of the whole device is reduced, and the whole device is more compact.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic diagram of a rotary sampling micro-carousel full-automatic luminescence immunoassay system of the present invention;
FIG. 2 is a schematic view of a partial structure of the present invention;
FIG. 3 is a schematic view of the structure of the present invention at different viewing angles;
FIG. 4 is a top view of the present invention;
FIG. 5 is a schematic diagram of the structure of the reagent kit of the present invention;
FIG. 6 is a schematic diagram of a sampling assembly of the present invention;
fig. 7 is a schematic diagram of the internal structure of the sampling assembly of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "open," "upper," "lower," "thickness," "top," "middle," "length," "inner," "peripheral," and the like indicate orientation or positional relationships, merely for convenience in describing the present invention and to simplify the description, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.
As shown in fig. 1 to 4, a rotary sampling micro-carousel type full-automatic luminescence immunoassay system comprises a bottom plate 1, an incubation plate 2, a reaction carousel 3, a cuvette automatic loading assembly 4, a reagent cartridge 5, a sample cartridge 6, a sampling assembly 7, a cleaning station assembly 8, a darkroom assembly 9, a micro-mechanical arm 91 and a bar code recognition device 10, wherein the incubation plate 2, the reaction carousel 3, the cuvette automatic loading assembly 4, the sampling assembly 7, the cleaning station assembly 8, the darkroom assembly 9, the micro-mechanical arm 91 and the bar code recognition device 10 are fixedly installed at the upper end of the bottom plate 1, and the sample cartridge 6 is rotatably installed on the bottom plate 1 around an axis.
The sampling assembly 7 is located between the reaction carousel 3 and the sample cartridge 6.
The upper part of the incubation plate 2 is coaxially provided with a reaction rotary plate 3, a plurality of reaction cup grooves 31 are axially distributed on the reaction rotary plate 3, the bottom and the side surface of each reaction cup groove 31 are provided with through holes, the reaction rotary plate 3 can rotate around the axis, and the reaction cup grooves 31 are partially positioned in the incubation plate 2.
A reagent bin 5 is coaxially arranged above the incubation plate 2, the reagent bin 5 can rotate around an axis, a plurality of reagent placing boxes 51 are axially distributed on the reagent bin 5, and as shown in fig. 5, a plurality of reagent placing holes 52 are formed in the reagent placing boxes 51; when in use, the reagent tube is manually placed in the reagent placing hole 52 of the placing box 51, and the reagent bin 5 is coaxially arranged on the incubation plate 2, so that the layout space of the whole device is reduced, and the whole device is more compact.
The sample bin 6 comprises a sample chassis 61 and sample racks 62, wherein the sample chassis 61 can be rotatably arranged on the bottom plate 1 around an axis, the sample racks 62 which are axially distributed are arranged on the sample chassis 61, and sample tubes are clamped between the sample racks 62; when in use, the sample tube is manually placed between the sample frames 62 of the sample bin 6, the whole sample bin 6 is cylindrical, and the layout space of the whole device is reduced.
The bar code recognition device 10 (such as a bar code scanner) is located at one side of the sample bin 6, and is used for recognizing the identity bar code on the sample tube placed in the sample bin 6, and uniquely marking the sample, so that the later identification of the sample luminescence immunoassay data is facilitated.
As shown in fig. 6 to 7, the sampling assembly 7 comprises a Z-axis moving mechanism 71, a rotating mechanism 72 and a sample adding needle 73, wherein the Z-axis moving mechanism 71 is arranged on the base plate 1, the rotating mechanism 72 is arranged on the Z-axis moving mechanism 71, the rotating mechanism 72 is provided with the sample adding needle 73, and the sample adding needle 73 is connected with a sample adding pump through a pipeline; the sample application needle 73 of the sampling assembly 7 applies the reagent in the reagent cartridge and the sample in the sample tube to the cuvette by moving in the Z-axis direction and rotating around the rotating mechanism 72.
The Z-axis moving mechanism 71 includes a Z-axis fixing frame 711 and a Z-axis timing belt 712, wherein the Z-axis fixing frame 711 is fixed on the base plate 1, and the Z-axis timing belt 712 is mounted on the Z-axis fixing frame 711; the rotating mechanism 72 comprises a rotating arm 721, a rotating synchronous belt 722, a rotating seat 723 and a guide rod 724, wherein the rotating arm 721 is fixed on the Z-axis synchronous belt 712 to realize the Z-axis movement of the rotating arm 721, the rotating synchronous belt 722 is fixedly arranged on the Z-axis fixing frame 711, the rotating seat 723 is connected with the rotating seat 722 in an engaged manner, the rotating synchronous belt 722 drives the rotating seat 723 to rotate, the lower end of the rotating arm 721 is provided with the guide rod 724, the guide rod 724 is connected with the rotating seat 723 in a sliding manner along the Z-axis direction, the rotating seat 723 drives the rotating arm 721 to rotate through the guide rod 724, and the sample feeding needle 73 is fixed on the rotating arm 721.
The sample adding needle 73 on the sampling assembly 7 moves in the Z-axis direction and rotates around the guide rod 724 to realize sample adding, compared with the prior art, the movement stroke of the sampling assembly 7 in the process of adding reagents in a reagent box and samples in a sample test tube into a reaction cup is reduced, the whole movement stroke time is reduced (for example, a large mechanical arm in a full-automatic biochemical and luminous immunoassay system of patent number: CN201310312544.7 realizes sample adding through movement in the X-axis direction, the Y-axis direction and the Z-axis direction, the movement stroke of the sampling needle in the sample adding process is increased), and meanwhile, the structure is more compact.
The automatic cuvette loading unit 4 loads transparent cuvettes into the reaction turntable 3 during measurement, and manually places reagent tubes into the placement boxes of the reagent chambers 5 and sample tubes into the sample chambers 6.
The automatic loading assembly 4 (such as the cup-arranging device, slideway and funnel assembly disclosed in the full-automatic biochemical and luminous immunoassay system of patent number CN 201310312544.7) of the reaction cup makes the reaction cup in the hopper fall into the reaction cup groove 31 according to the determined orientation, and continuously loads the reaction cup into the reaction turntable 3.
After the sample is added, the reaction cup to which the sample is just added is rotated to a vibration mixing position, and the ejector rod is lifted to be in contact with the reaction cup through an ejector rod driving device of a vibration mixing component (such as a mixing component disclosed in a full-automatic biochemical and luminous immunoassay system of patent number CN 201310312544.7), and the reaction cup is separated from the bottom of the turntable by a certain distance, and then the vibrator is electrified, so that the vibrator vibrates, and the reaction cup is driven to vibrate, so that reactants in the reaction cup are uniformly mixed. After the completion of the mixing, the jack was allowed to fall down, the reaction cup was allowed to fall to the bottom of the turntable, and incubation was performed in an incubation tray 2 capable of maintaining a constant temperature.
When the incubation time of a certain cuvette reaches a prescribed time, the cuvette is transferred to a washing position.
The cleaning station assembly 8 is arranged on the outer side of the reaction turntable 3, a darkroom assembly 9 is arranged at one end of the cleaning station assembly 8, and a photon measuring assembly is arranged on one side of the darkroom assembly 9.
The micro-mechanical arm 91 is installed among the reaction turntable 3, the cleaning station assembly 8 and the darkroom assembly 9, and the distance from the rotation axis of the micro-mechanical arm 91 to the cup starting position on the reaction turntable 3 is equal to the distance from each cup groove and the waste cup groove on the reaction cup seat in the cleaning station assembly 8 and the distance from the cup groove on the darkroom drawer measured in the open state.
When the reaction cup rotates to the cleaning position, the micro-mechanical arm 91 moves the reaction cup onto the reaction cup seat of the cleaning station assembly 8 (such as a reaction cup for a luminescence tester and a cleaning separation mechanism of a corresponding cleaning separation mechanism of the reaction cup in patent number cn201410856244. X), after the reaction cup filled with reactants is placed at a specific position of the cleaning rotary table, the cleaning rotary table rotates according to a certain time period, sequentially passes through the separation magnet to reach the lower part of the needle and the needle, the needle firstly pumps the liquid in the cup, then the needle firstly pumps the liquid in the cup, and then the needle secondly injects the liquid into the cup, and when the reaction cup reaches the last needle, the magnetic beads move from one side to the other side of the cup, thereby ensuring the reliability and the repeatability of the measurement result, reducing the cleaning times, accelerating the test speed, and in some cases, the last several magnets can be placed below the reaction cup to move the beads to the bottom of the reaction cup.
After cleaning, if a one-step process is performed, the reaction cup is moved by the micro-robot 91 into a drawer cup slot of the darkroom assembly 9 (e.g., a measurement darkroom as disclosed in a full-automatic biochemical and luminescent immunoassay system of patent number CN 201310312544.7).
Closing the drawer, sealing the darkroom assembly 9, opening the shading plate in the darkroom assembly 9, adding the excitation reagent by the excitation reagent pump according to a specified program through the excitation reagent needle on the base of the darkroom assembly 9, starting the chemiluminescent reaction of the reactant in the reaction cup, measuring the produced light, and sending the measured result into the computer for processing.
After the measurement is finished, the drawer of the darkroom assembly 9 is opened, the reaction cup is moved into the waste cup groove on the reaction cup seat of the cleaning station by the micro-mechanical arm 91, the waste liquid is pumped away by the waste liquid pump through the waste liquid needle group, then the reaction cup moving support is moved, the through hole on the support is moved to the lower part of the waste cup groove, and the waste reaction cup falls into the waste reaction cup channel, so that the outside of the instrument is led out.
For some reagent two-step or three-step methods, after the cleaning, the micro-mechanical arm 91 does not send the reaction cup to the darkroom assembly 9, but sends the reaction cup back to the reaction turntable 3 again, and then the sample adding and incubation processes are performed, and the subsequent procedures are the same as those of the one-step method.
To reduce cross-contamination, the loading needle 73 is returned to the rinse station for rinsing after each sample and loading cycle. The inner and outer walls of the needle are rinsed by a rinsing pump, and the rinsed liquid is pumped away by a liquid pump.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims.
Claims (6)
1. The utility model provides a full-automatic luminous immunoassay system of rotatory sampling miniature carousel formula, including bottom plate (1), incubation dish (2), reaction carousel (3), reaction cup automatic loading subassembly (4), reagent storehouse (5), sample storehouse (6), sampling subassembly (7), wash station subassembly (8), darkroom subassembly (9) and miniature arm (91), install the reaction carousel (3) around axis pivoted on the incubation dish (2) coaxially, a plurality of reaction cup grooves (31) are distributed on the reaction carousel (3) axially, and reaction cup groove (31) are in part in incubation dish (2), reaction cup automatic loading subassembly (4) are located incubation dish (2) outside, wash station subassembly (8) are installed in the outside of reaction carousel (3), install darkroom subassembly (9) in one side of wash station subassembly (8), install between reaction carousel (3), wash station subassembly (8) and darkroom subassembly (9) miniature arm (91), its characterized in that, install sample storehouse (6) around axis pivoted on bottom plate (1);
the sampling assembly (7) is positioned between the reaction turntable (3) and the sample bin (6);
A rotating reagent bin (5) is coaxially arranged above the incubation tray (2);
The incubation plate (2), the reaction turntable (3), the reaction cup automatic loading assembly (4), the sampling assembly (7), the cleaning station assembly (8), the darkroom assembly (9) and the micro-mechanical arm (91) are fixedly arranged at the upper end of the bottom plate (1);
The sampling assembly (7) comprises a Z-axis movement mechanism (71), a rotating mechanism (72) and a sample adding needle (73), wherein the Z-axis movement mechanism (71) is arranged on the bottom plate (1), the rotating mechanism (72) is arranged on the Z-axis movement mechanism (71), the sample adding needle (73) is arranged on the rotating mechanism (72), and the sample adding needle (73) is connected with the sample adding pump through a pipeline.
2. The rotary sampling miniature turntable type full-automatic luminous immunoassay system according to claim 1, wherein a plurality of reagent placing boxes (51) are axially distributed on the reagent bin (5), and a plurality of reagent placing holes (52) are formed in the reagent placing boxes (51).
3. The rotary sampling micro rotary disk type full-automatic luminous immunoassay system according to claim 1, wherein the sample bin (6) comprises a sample chassis (61) and sample racks (62), wherein the sample chassis (61) is rotatably mounted on the bottom plate (1) around an axis, the sample racks (62) which are axially distributed are mounted on the sample chassis (61), and the sample tubes are clamped between the sample racks (62).
4. The rotary sampling micro rotary disc type full-automatic luminous immunoassay system according to claim 1, wherein the Z-axis movement mechanism (71) comprises a Z-axis fixing frame (711) and a Z-axis synchronous belt (712), wherein the Z-axis fixing frame (711) is fixed on the base plate (1), and the Z-axis synchronous belt (712) is installed on the Z-axis fixing frame (711).
5. The rotary sampling micro rotary table type full-automatic luminous immunoassay system according to claim 4, wherein the rotary mechanism (72) comprises a rotary arm (721), a rotary synchronous belt (722), a rotary seat (723) and a guide rod (724), the rotary arm (721) is fixed on the Z-axis synchronous belt (712), the rotary synchronous belt (722) is fixedly installed on the Z-axis fixing frame (711), the rotary seat (723) is connected with the rotary seat (722) in an engaged manner, the guide rod (724) is installed at the lower end of the rotary arm (721), the guide rod (724) is connected with the rotary seat (723) in a sliding manner along the Z-axis direction, and the sample adding needle (73) is fixed on the rotary arm (721).
6. The rotary sampling micro rotary disc type full-automatic luminous immunoassay system according to claim 1, further comprising a bar code identification device (10), wherein the bar code identification device (10) is fixedly arranged at the upper end of the bottom plate (1), and the bar code identification device (10) is positioned at one side of the sample bin (6).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910443685.XA CN110146712B (en) | 2019-05-27 | 2019-05-27 | Rotary sampling miniature turntable type full-automatic luminous immunoassay system |
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| CN201910443685.XA CN110146712B (en) | 2019-05-27 | 2019-05-27 | Rotary sampling miniature turntable type full-automatic luminous immunoassay system |
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| CN111856050B (en) * | 2020-07-04 | 2024-03-29 | 欧亚先锋生物技术投资(北京)有限责任公司 | Full-automatic immunoblotter and detection method |
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