CN110146712A - A kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling - Google Patents
A kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling Download PDFInfo
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- CN110146712A CN110146712A CN201910443685.XA CN201910443685A CN110146712A CN 110146712 A CN110146712 A CN 110146712A CN 201910443685 A CN201910443685 A CN 201910443685A CN 110146712 A CN110146712 A CN 110146712A
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- 238000005070 sampling Methods 0.000 title claims abstract description 41
- 238000003018 immunoassay Methods 0.000 title claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 79
- 238000004140 cleaning Methods 0.000 claims abstract description 26
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 23
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- 238000011068 loading method Methods 0.000 claims abstract description 10
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- 238000005259 measurement Methods 0.000 description 8
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- 239000007788 liquid Substances 0.000 description 6
- 238000004020 luminiscence type Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
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- 230000035945 sensitivity Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011325 biochemical measurement Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 101150038956 cup-4 gene Proteins 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 238000009991 scouring Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
- G01N2035/1093—Cylindrical, e.g. variable radius and angle
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Abstract
The present invention discloses a kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling, including bottom plate, incubate disk, reaction turntable, the automatic loading assembly of reaction cup, agent bin, sample storehouse, sampling component, cleaning station component, darkroom component and micromachine arm, incubate the top installation reaction turntable of disk, multiple reaction cup slots are axially distributed on reaction turntable, micromachine arm is mounted between reaction turntable, cleaning station component and darkroom component, sample storehouse is installed on bottom plate, incubates and rotatable agent bin is installed on disk；Sampling needle on sampling component is sampled by moving in Z-direction and around sampling component rotation, reduce the movement travel during sampling is added in reaction cup for the reagent in kit or the sample in sample tube, it is further reduced the whole flow process time, improves working efficiency；It is coaxially mounted to incubate on disk using agent bin and cylindrical with sample storehouse, reduces whole device arrangement space, keep whole device more compact.
Description
Technical field
The present invention relates to biological monitoring and clinical examination equipment technical field, the miniature rotating disc type of specifically a kind of rotation sampling
Full-automatic luminescent immunoassay system.
Background technique
The development of science and technology, chemiluminescence and the biochemical measurement that shines become very common in recent years, they
Often it is used to determine the content of the non-principal component of certain in sample, and in the past ten years, the measurement that shines is in gene table
Reach and the research that adjusts in also played an important role, chemiluminescence be using the light excited in chemical reaction process, it is raw
Change the light to shine be using enzyme rushization is issued in chemical reaction process.Chemistry and biochemical luminous measuring technique and others
Measuring technique is compared, and has the advantage that high sensitivity, wide dynamic range, the luminous measurement reagent continued to bring out.It shines
Measurement has high sensitivity, it is 105 times higher than the sensitivity of spectral absorption measuring technique, at least than fluorescence measurement techniques
It is higher by 1000 times.
The applicant above-mentioned existing analyzer there are aiming at the problem that improve, carry out patent application (application number
A kind of Minitype rotating disc type full-automatic immunoluminescence analysis system capable of adding sample in whole disc of CN201120094994.X) it is authorized.
The one kind for being directed to application number CN201120094994.X is loaded the full-automatic immunoluminescence of miniature rotating disc type point totally
Analysis system has the following problems in the discovery of historical operation process:
1, sampling movement mechanism and sample-adding pump of the needle by the X-direction of big mechanical arm, Y direction and Z-direction is realized
Sample in reagent and sample tube in kit is added in reaction cup, movement travel phase during needle sample-adding of sampling at this time
To longer, the whole flow process working time of entire instrument is increased；
2, agent bin and sample storehouse are designed as distributed rectangular, and agent bin and sample storehouse are arranged separately in the bottom of system
Plate increases whole device arrangement space, keeps whole device not compact enough.
Summary of the invention
The purpose of the present invention is to provide a kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling, sampling
Sampling needle on component is sampled by movement in the Z-axis direction and around sampling component rotation, is reduced sampling and is directed to kit
In reagent and sample tube in sample be added in reaction cup during movement travel, when being further reduced whole flow process
Between, improve working efficiency；It is coaxially mounted to incubate on disk using agent bin and cylindrical with sample storehouse, reduces whole device cloth
Office space, keeps whole device more compact.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling, including bottom plate, incubation disk, reaction turn
The automatic loading assembly of disk, reaction cup, agent bin, sample storehouse, sampling component, cleaning station component, darkroom component and micromachine arm,
It incubates and is coaxially installed with the reaction turntable being rotated about axis above disk, react and multiple reaction cup slots are axially distributed on turntable,
And reaction cup slot part is in and incubates in disk, the automatic loading assembly of reaction cup, which is located at, to be incubated on the outside of disk, and cleaning station component is mounted on
The outside for reacting turntable is equipped with darkroom component in one end of cleaning station component, and micromachine arm is mounted on reaction turntable, cleaning
It stands between component and darkroom component, which is characterized in that the sample storehouse being rotated about axis is installed on the bottom plate.
The sampling component is located between reaction turntable and sample storehouse.
It is described to incubate the agent bin that rotation is co-axially mounted above disk.
Further, the incubation disk, reaction turntable, the automatic loading assembly of reaction cup, sampling component, cleaning station component,
Darkroom component and micromachine arm are fixedly mounted on bottom plate upper end.
Further, multiple reagent holders are axially distributed on the agent bin, are provided with multiple examinations in reagent holder
Agent putting hole.
Further, the sample storehouse includes sample chassis and sample rack, and wherein sample chassis, which is rotated about axis, is mounted on
On bottom plate, the sample rack being axially distributed is installed on sample chassis, sample tube is fastened between sample rack.
Further, the sampling component includes Z axis movement mechanism, rotating mechanism and sample needle, the installation of Z axis movement mechanism
On bottom plate, rotating mechanism is mounted on Z axis movement mechanism, and rotating mechanism is equipped with sample needle, and sample needle is by pipeline and adds
Sample pump is connected.
Further, the Z axis movement mechanism includes Z axis fixed frame and Z axis synchronous belt, and wherein Z axis fixed frame is fixed on
On bottom plate, Z axis synchronous belt is installed on Z axis fixed frame.
Further, the rotating mechanism includes rotating arm, rotation synchronization belt, rotating seat and guide rod, and rotating arm is fixed
On Z axis synchronous belt, rotation synchronization belt is fixedly mounted on Z axis fixed frame, and rotation synchronization belt internal messing is connected with rotating seat, rotation
Pivoted arm lower end is equipped with guide rod, is slidably connected between guide rod and rotating seat along Z-direction, and wherein sample needle is fixed on rotation
On pivoted arm.
Further, described further includes barcode recognition apparatus, and barcode recognition apparatus is fixedly mounted on bottom plate upper end, item
Shape code identification device is located at sample storehouse side.
Beneficial effects of the present invention:
The present invention is further improved in the prior art, is equally possessing the (application of existing luminescence immunoassay system
Number CN201120094994.X) function under the premise of, sampling needle by movement in the Z-axis direction and around component of sampling rotate into
Line sampling reduces the movement row during sampling is added in reaction cup for the sample in the reagent and sample tube in kit
Journey is further reduced the whole flow process time, improves working efficiency；Using agent bin be coaxially mounted to incubate disk on and and sample storehouse
It is cylindrical, whole device arrangement space is reduced, keeps whole device more compact.
Detailed description of the invention
The present invention will be further described below with reference to the drawings.
Fig. 1 is the miniature rotating disc type Full-automatic luminescent immunoassay system structural schematic diagram of present invention rotation sampling；
Fig. 2 is partial structural diagram of the present invention；
Fig. 3 is different perspectives structural schematic diagram of the present invention；
Fig. 4 is top view of the present invention；
Fig. 5 is reagent holder structural schematic diagram of the present invention；
Fig. 6 is present invention sampling component structure diagram；
Fig. 7 is present invention sampling component schematic diagram of internal structure.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all other
Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " aperture ", "upper", "lower", " thickness ", "top", " in ",
Indicating positions or the positional relationship such as " length ", "inner", " surrounding ", are merely for convenience of description of the present invention and simplification of the description, without
It is that the component of indication or suggestion meaning or element must have a particular orientation, is constructed and operated in a specific orientation, therefore not
It can be interpreted as limitation of the present invention.
As shown in Figures 1 to 4, the miniature rotating disc type Full-automatic luminescent immunoassay system of a kind of rotation sampling, including bottom plate
1, disk 2, reaction turntable 3, the automatic loading assembly 4 of reaction cup, agent bin 5, sample storehouse 6, sampling component 7, cleaning station component are incubated
8, darkroom component 9, micromachine arm 91 and barcode recognition apparatus 10 fill automatically wherein incubating disk 2, reaction turntable 3, reaction cup
It is fixed to carry component 4, sampling component 7, cleaning station component 8, darkroom component 9, micromachine arm 91 and barcode recognition apparatus 10
It is mounted on 1 upper end of bottom plate, sample storehouse 6, which is rotated about axis, to be mounted on bottom plate 1.
Component 7 of sampling is located between reaction turntable 3 and sample storehouse 6.
The top for incubating disk 2 is coaxially installed with reaction turntable 3, reacts and multiple reaction cup slots 31 are axially distributed on turntable 3,
The bottom and side of each reaction cup slot 31 are provided with through-hole, and reaction turntable 3 can be rotated about axis, and 31 part of reaction cup slot
In incubation disk 2.
It is coaxially installed with agent bin 5 in the top for incubating disk 2, agent bin 5 can be rotated about axis, axial on agent bin 5
Multiple reagent holders 51 are distributed with, as shown in figure 5, being provided with multiple reagent putting holes 52 in reagent holder 51；In use, will
Reagent Tube is manually placed in the reagent putting hole 52 of holder 51, is coaxially mounted to incubate on disk 2 using agent bin 5, be reduced
Whole device arrangement space keeps whole device more compact.
Sample storehouse 6 includes sample chassis 61 and sample rack 62, and wherein sample chassis 61 can be rotated about axis and be mounted on bottom
On plate 1, the sample rack 62 being axially distributed is installed on sample chassis 61, sample tube is fastened between sample rack 62；In use, people
Sample tube is put between the sample rack 62 of sample storehouse 6 by work, and entire sample storehouse 6 is cylindrical, reduces whole device arrangement space.
Barcode recognition apparatus 10 (such as bar code scanner) is located at 6 side of sample storehouse, to the sample being placed in sample storehouse 6
The upper ID bar code of this pipe is identified, uniqueness label is carried out to sample, convenient for the later period to sample luminescence immunoassay data
Identification.
As shown in Figure 6 to 7, sampling component 7 includes Z axis movement mechanism 71, rotating mechanism 72 and sample needle 73, Z axis fortune
Motivation structure 71 is mounted on bottom plate 1, and rotating mechanism 72 is mounted on Z axis movement mechanism 71, and rotating mechanism 72 is equipped with sample needle
73, sample needle 73 is connected by pipeline with sample-adding pump；Sample component 7 on sample needle 73 by the Z-axis direction movement and around
Rotating mechanism 72 rotates, and the sample in the reagent and sample tube in kit is added in reaction cup, is loaded.
Z axis movement mechanism 71 includes Z axis fixed frame 711 and Z axis synchronous belt 712, and wherein Z axis fixed frame 711 is fixed on bottom
On plate 1, Z axis synchronous belt 712 is installed on Z axis fixed frame 711；Rotating mechanism 72 include rotating arm 721, rotation synchronization belt 722,
Rotating seat 723 and guide rod 724, rotating arm 721 are fixed on Z axis synchronous belt 712, realize the Z axis movement of rotating arm 721, rotation
Turn synchronous belt 722 to be fixedly mounted on Z axis fixed frame 711,722 internal messing of rotation synchronization belt is connected with rotating seat 723, and rotation is same
Walking band 722 drives rotating seat 723 to rotate, and 721 lower end of rotating arm is equipped with guide rod 724, guide rod 724 and rotating seat 723 it
Between be slidably connected along Z-direction, rotating seat 723 drives rotating arm 721 to rotate by guide rod 724, and wherein sample needle 73 is solid
It is scheduled on rotating arm 721.
The sample needle 73 sampled on component 7 is rotated by movement in the Z-axis direction and around guide rod 724, realizes sample-adding, phase
For the prior art, the sampling for reducing sampling component 7 is added to reaction for the sample in the reagent and sample tube in kit
Movement travel during in cup, reducing the entire movement travel time, (such as patent No.: one kind of CN201310312544.7 is complete certainly
Big mechanical arm in dynamic biochemical and luminescence immunoassay system passes through the movement realization in X-direction, Y direction and Z-direction
Sample-adding increases movement travel during sampling needle sample-adding), while making more compact structure.
Transparent reaction cup is downloaded in reaction turntable 3 by the automatic loading assembly 4 of reaction cup when measurement, manually puts Reagent Tube
In the holder for entering agent bin 5, sample tube is put into sample storehouse 6.
The automatic loading assembly of reaction cup 4 (exempt from by a kind of full-automatic biochemical of such as patent No. CN201310312544.7 and shining
A glass collating unit, slideway and funnel assembly are answered disclosed in epidemic disease analysis system) make the reaction cup being located in its hopper by determining
Orientation is fallen into reaction cup slot 31, constantly loads reaction cup in Xiang Fanying turntable 3.
After the completion of sample-adding, the reaction cup for just having added sample is gone at vibration mixing, component (such as patent No. is mixed by vibration
Mix component disclosed in a kind of full-automatic biochemical and luminescence immunoassay system of CN201310312544.7) top rod driving
Device contacts mandril rise with reaction cup, and reaction cup is made to leave turntable bottom certain distance, is powered at this time to oscillator, makes to shake
Son generates vibration, so that reaction cup be driven to vibrate, the reactant for keeping it internal is mixed.After mixing, fall mandril,
Reaction cup falls on the bottom of turntable, is incubated in the incubation disk 2 for being able to maintain constant temperature.
After time as defined in reaching when the incubative time of some reaction cup, which is gone into cleaning positions.
Cleaning station component 8 is mounted on the outside of reaction turntable 3, is equipped with darkroom component 9 in one end of cleaning station component 8,
In darkroom, the side of component 9 is equipped with photon survey component.
Micromachine arm 91 is mounted between reaction turntable 3, cleaning station component 8 and darkroom component 9, micromachine arm 91
Pivot center to reaction turntable 3 on play the distance of glass position and react that each glass of slot on cup holder, give up cup with into cleaning station component 8
It the distance of slot and is equal at a distance from cup slot with onto lower measurement darkroom drawer in the open state.
When reaction cup rotates cleaning positions, reaction cup is moved to 8 (such as patent No. of cleaning station component by micromachine arm 91
A kind of luminous tester reaction cup of CN201410856244.X and its washing separator structure of corresponding washing separator structure)
Reaction cup holder on, after the reaction cup equipped with reactant is placed into the specific position of cleaning turntable, cleaning turntable is by certain
Time cycle rotation passes sequentially through the lower section that separation magnet reaches drawn needle, washes needle, and drawn needle first takes the liquid in cup away, then
It washes needle washing lotion is injected into cup, then turntable continues to rotate by period regular hour, passes sequentially through separation magnet, reaches
Drawn needle, the lower section for washing needle, drawn needle first take the liquid in cup away, then wash needle and washing lotion is injected into cup, arrive in reaction cup
When up to last root drawn needle, magnetic bead realizes that from cup side to move on to other side 3 times mobile, to ensure that measurement result
Reproducibility and reliability, and wash number is reduced, accelerate test speed, in some cases, last several magnet can be put
It sets in the lower section of reaction cup, magnetic bead is moved on to the bottom of reaction cup.
After cleaning, if it is one-step method, then reaction cup is moved to darkroom component 9 (as specially by micromachine arm 91
Measure darkroom disclosed in a kind of full-automatic biochemical and luminescence immunoassay system of benefit CN201310312544.7) drawer
In cup slot.
Drawer is closed, darkroom component 9 is sealed, while barn door is opened in darkroom component 9, passes through 9 base of darkroom component
Excitation reagent, reaction in starting reaction cup can be added by excitation reagent pump according to the program of regulation in excitation reagent needle on seat
The chemiluminescence reaction of object measures the light of output, and the result of measurement is sent into computer and is handled.
After measurement, component 9 drawer in darkroom is opened, and reaction cup is moved to cleaning station reaction cup by micromachine arm 91
In useless cup slot on seat, waste drains pump is taken away waste liquid by waste liquid needle group, and then the mobile bracket of mobile response cup, makes on the bracket
Through-hole move on to the lower section of useless cup slot, which is fallen into discarded reaction cup channel, to draw the outside of instrument.
For the two-step method or three-step approach of some reagents, after cleaning, micromachine arm 91 is not to be sent into reaction cup
Darkroom component 9, but reaction cup is sent back to reaction turntable 3 again, then executes the process of sample-adding, incubation, subsequent program then and
One-step method is identical.
In order to reduce cross contamination, it is each sampling and sample-adding end cycle after, sample needle 73 return to scouring stage into
Row rinses.It is rinsed by inside and outside wall of the flushing pump to needle, the liquid of flushing is taken away by drawing liquid pump.
In the description of this specification, the description of reference term " one embodiment ", " example ", " specific example " etc. means
Particular features, structures, materials, or characteristics described in conjunction with this embodiment or example are contained at least one implementation of the invention
In example or example.In the present specification, schematic expression of the above terms may not refer to the same embodiment or example.
Moreover, particular features, structures, materials, or characteristics described can be in any one or more of the embodiments or examples to close
Suitable mode combines.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.
Claims (8)
- The miniature rotating disc type Full-automatic luminescent immunoassay system 1. a kind of rotation is sampled, including bottom plate (1), incubation disk (2), reaction Turntable (3), the automatic loading assembly of reaction cup (4), agent bin (5), sample storehouse (6), sampling component (7), cleaning station component (8), Darkroom component (9) and micromachine arm (91) incubate and are coaxially installed with the reaction turntable (3) being rotated about axis above disk (2), Multiple reaction cup slots (31) are axially distributed in reaction turntable (3), and reaction cup slot (31) is partially in and incubates in disk (2), instead It answers the automatic loading assembly of cup (4) to be located to incubate on the outside of disk (2), cleaning station component (8) is mounted on the outside of reaction turntable (3), The side of cleaning station component (8) is equipped with darkroom component (9), and micromachine arm (91) is mounted on reaction turntable (3), cleaning station group Between part (8) and darkroom component (9), which is characterized in that the sample storehouse (6) being rotated about axis is installed on the bottom plate (1)；The sampling component (7) is located between reaction turntable (3) and sample storehouse (6)；It is described to incubate the agent bin (5) that rotation is co-axially mounted above disk (2).
- The miniature rotating disc type Full-automatic luminescent immunoassay system 2. a kind of rotation according to claim 1 is sampled, feature It is, the incubation disk (2), reaction turntable (3), the automatic loading assembly of reaction cup (4), sampling component (7), cleaning station component (8), darkroom component (9) and micromachine arm (91) are fixedly mounted on bottom plate (1) upper end.
- The miniature rotating disc type Full-automatic luminescent immunoassay system 3. a kind of rotation according to claim 1 is sampled, feature It is, multiple reagent holders (51) is axially distributed on the agent bin (5), are provided with multiple reagents in reagent holder (51) Putting hole (52).
- The miniature rotating disc type Full-automatic luminescent immunoassay system 4. a kind of rotation according to claim 1 is sampled, feature It is, the sample storehouse (6) includes sample chassis (61) and sample rack (62), and wherein sample chassis (61) are rotated about axis installation On bottom plate (1), the sample rack (62) being axially distributed is installed on sample chassis (61), sample tube be fastened on sample rack (62) it Between.
- The miniature rotating disc type Full-automatic luminescent immunoassay system 5. a kind of rotation according to claim 1 is sampled, feature It is, the sampling component (7) includes Z axis movement mechanism (71), rotating mechanism (72) and sample needle (73), Z axis movement mechanism (71) it is mounted on bottom plate (1), rotating mechanism (72) is mounted on Z axis movement mechanism (71), and rotating mechanism (72), which is equipped with, to be added Sample needle (73), sample needle (73) are connected by pipeline with sample-adding pump.
- The miniature rotating disc type Full-automatic luminescent immunoassay system 6. a kind of rotation according to claim 5 is sampled, feature It is, the Z axis movement mechanism (71) includes Z axis fixed frame (711) and Z axis synchronous belt (712), wherein Z axis fixed frame (711) It is fixed on bottom plate (1), Z axis synchronous belt (712) is installed on Z axis fixed frame (711).
- The miniature rotating disc type Full-automatic luminescent immunoassay system 7. a kind of rotation according to claim 6 is sampled, feature It is, the rotating mechanism (72) includes rotating arm (721), rotation synchronization belt (722), rotating seat (723) and guide rod (724), rotating arm (721) is fixed on Z axis synchronous belt (712), and rotation synchronization belt (722) is fixedly mounted on Z axis fixed frame (711) on, rotation synchronization belt (722) internal messing is connected with rotating seat (723), and rotating arm (721) lower end is equipped with guide rod (724), it is slidably connected between guide rod (724) and rotating seat (723) along Z-direction, wherein sample needle (73) is fixed on rotation On pivoted arm (721).
- The miniature rotating disc type Full-automatic luminescent immunoassay system 8. a kind of rotation according to claim 1 is sampled, feature It is, described further includes barcode recognition apparatus (10), and barcode recognition apparatus (10) is fixedly mounted on bottom plate (1) upper end, item Shape code identification device (10) is located at sample storehouse (6) side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910443685.XA CN110146712B (en) | 2019-05-27 | 2019-05-27 | Rotary sampling miniature turntable type full-automatic luminous immunoassay system |
Applications Claiming Priority (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111856050A (en) * | 2020-07-04 | 2020-10-30 | 欧亚先锋生物技术投资(北京)有限责任公司 | Full-automatic immunoblotting instrument and detection method |
| CN112213508A (en) * | 2020-10-22 | 2021-01-12 | 合肥运涛光电科技有限公司 | High-flux full-automatic immune luminescence analysis system |
| CN116008046A (en) * | 2022-12-26 | 2023-04-25 | 广州市进德生物科技有限公司 | Automatic diluting and sample adding device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110256629A1 (en) * | 2010-04-14 | 2011-10-20 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Fully automatic biochemical analyzer and analyzing method thereof |
| CN202075285U (en) * | 2011-04-02 | 2011-12-14 | 合肥运涛光电科技有限公司 | Minitype rotating disc type full-automatic immunoluminescence analysis system capable of adding sample in whole disc |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN106980026A (en) * | 2017-03-29 | 2017-07-25 | 盐城拜明生物技术有限公司 | Automatic chemiluminescence immunoassay detects performs device |
| CN208092069U (en) * | 2018-03-13 | 2018-11-13 | 张玉兰 | Small size automatic chemical illumination immunity analysis instrument |
| CN210181061U (en) * | 2019-05-27 | 2020-03-24 | 合肥运涛光电科技有限公司 | Rotary sampling micro rotary disc type full-automatic luminescence immunoassay system |
-
2019
- 2019-05-27 CN CN201910443685.XA patent/CN110146712B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110256629A1 (en) * | 2010-04-14 | 2011-10-20 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Fully automatic biochemical analyzer and analyzing method thereof |
| CN202075285U (en) * | 2011-04-02 | 2011-12-14 | 合肥运涛光电科技有限公司 | Minitype rotating disc type full-automatic immunoluminescence analysis system capable of adding sample in whole disc |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN106980026A (en) * | 2017-03-29 | 2017-07-25 | 盐城拜明生物技术有限公司 | Automatic chemiluminescence immunoassay detects performs device |
| CN208092069U (en) * | 2018-03-13 | 2018-11-13 | 张玉兰 | Small size automatic chemical illumination immunity analysis instrument |
| CN210181061U (en) * | 2019-05-27 | 2020-03-24 | 合肥运涛光电科技有限公司 | Rotary sampling micro rotary disc type full-automatic luminescence immunoassay system |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111856050A (en) * | 2020-07-04 | 2020-10-30 | 欧亚先锋生物技术投资(北京)有限责任公司 | Full-automatic immunoblotting instrument and detection method |
| CN111856050B (en) * | 2020-07-04 | 2024-03-29 | 欧亚先锋生物技术投资(北京)有限责任公司 | Full-automatic immunoblotter and detection method |
| CN112213508A (en) * | 2020-10-22 | 2021-01-12 | 合肥运涛光电科技有限公司 | High-flux full-automatic immune luminescence analysis system |
| CN112213508B (en) * | 2020-10-22 | 2024-04-19 | 复星诊断科技(合肥)有限公司 | High-flux full-automatic immune luminescence analysis system |
| CN116008046A (en) * | 2022-12-26 | 2023-04-25 | 广州市进德生物科技有限公司 | Automatic diluting and sample adding device |
| CN116008046B (en) * | 2022-12-26 | 2023-11-10 | 广州市进德生物科技有限公司 | Automatic diluting and sample adding device |
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