CN215115900U - Sample joint inspection analysis system - Google Patents

Abstract

The utility model discloses a sample joint inspection analytic system. This sample joint inspection analytic system includes the frame and set up in sample processing device, chemiluminescence immunoassay device, biochemical analysis device in the frame, sample processing device includes immunity introduction channel and biochemical introduction channel, immunity introduction channel with chemiluminescence immunoassay device intercommunication, biochemical introduction channel with biochemical analysis device intercommunication. The sample joint inspection analysis system has the advantages of small structure and high detection speed, can realize multi-item joint inspection based on a biochemical reaction principle and a chemiluminescence detection principle, exerts the test advantages of biochemical reaction and immunoreaction, has no mutual interference of two test modes, can meet the requirements of various medical treatments, detection mechanisms or unit high-flux and high-sensitivity multi-item joint inspection, and simultaneously improves various choices for patients.

Description

Sample joint inspection analysis system

Technical Field

The utility model relates to the field of medical equipment and biological detection, in particular to a sample joint inspection analysis system.

Background

In the field of in vitro diagnosis of medical examination equipment, the trend of combining multi-item detection indexes, detection standardization and package edification is more and more obvious. For example, C-reactive protein (CRP), Serum Amyloid A (SAA), Procalcitonin (PCT) are the main criteria for experimental examinations of infectious diseases, for diagnosis and identification of infections. However, due to the different contents of different analytes in the sample, the detection sensitivity and the linear range requirements of different items are different. Meanwhile, limited by the detection technical conditions, it is difficult to realize joint detection of multiple antigens or antibodies with large content difference (content difference is more than 100 times) in a single sample. As for the above-mentioned measurement of CRP, SAA and PCT, CRP and SAA are substances at a level of mg, and PCT is a substance at a level of pg. In this case, the immunoturbidimetric assay currently available using the biochemical reaction principle, such as CRP and SAA, is still tested by the turbidimetric assay. For the highly sensitive PCT project, chemiluminescence detection was used. The two detection methods are based on test systems of completely different principles. In a traditional detection system, different test systems are dispersed in different instruments, so that a plurality of samples need to be extracted and sent to different machines, or one sample is moved to another machine for testing after the test of one instrument is completed, so that great operation inconvenience is brought to customers and detection personnel. In addition, many current basic health units are limited by financial resources, material resources and space, and can not be simultaneously provided with a plurality of different types of detection instruments to configure a plurality of different test systems, but patients have the requirement of simultaneously detecting a plurality of different test systems, so that the existing detection conditions of the basic health units are difficult to meet the detection requirement of the patients.

SUMMERY OF THE UTILITY MODEL

Based on this, there is a need for a sample joint inspection analysis system. The utility model discloses a sample joint inspection analytic system structure is miniaturized, detects the rapidization, can realize the multinomial project joint inspection based on biochemical reaction principle and chemiluminescence detection principle, and the test advantage of performance biochemical reaction and immunoreaction, and two kinds of test patterns can not mutual interference, can satisfy in the demand of various medical treatment, detection mechanism or unit high flux, high sensitivity's multiple joint inspection, also improved multiple selection for the patient simultaneously.

The utility model provides a sample joint inspection analytic system, includes the frame and set up in sample processing device, chemiluminescence immunoassay device, biochemical analysis device in the frame, sample processing device includes immunity introduction channel and biochemical introduction channel, immunity introduction channel with chemiluminescence immunoassay device intercommunication, biochemical introduction channel with biochemical analysis device intercommunication.

In one embodiment, the sample processing device further comprises a sample feeding bin mechanism, the sample feeding bin mechanism comprises a sample feeding seat, a sample feeding frame, a first sample feeding driving part and a second sample feeding driving part, the sample injection seat is arranged on the frame, the sample injection frame is movably connected with the sample injection seat, a plurality of sample stations for placing the sample frame are arranged on the sample injection frame in parallel, the first sample introduction driving part is connected with the sample introduction frame and used for driving the sample introduction frame to move along a first direction, each sample station can be respectively aligned with the immunity sample introduction channel and the biochemistry sample introduction channel, the second sample injection driving part is arranged on the sample injection seat and used for exerting actions on the sample rack in each sample station so as to enable the sample rack to move outwards to the immune sample injection channel or the biochemical sample injection channel along a second direction.

In one embodiment, the immuno sample injection channel is disposed in parallel with the biochemical sample injection channel, the first direction is perpendicular to the immuno sample injection channel or the biochemical sample injection channel, and the second direction is disposed in parallel with the immuno sample injection channel or the biochemical sample injection channel.

In one embodiment, the chemiluminescence immunoassay device comprises a reaction cup arrangement mechanism, a reaction cup feeding mechanism, a vortex mixer, an immune incubator, a reaction cup moving mechanism, a reading station, an immune magnetic separation cleaning mechanism, an immune reagent disc and an immune feeding mechanism, the reaction cup arrangement mechanism is used for arranging and sequencing reaction cups, the reaction cup feeding mechanism is connected with the reaction cup arrangement mechanism, the reaction cup feeding mechanism is provided with a plurality of reaction cup stations for accommodating the reaction cups, the reaction cup moving mechanism is used for transferring the reaction cups among the reaction cup feeding mechanism, the vortex mixer, the immune incubator, the reading station and the immune magnetic separation cleaning mechanism, the immune feed mechanism is used for respectively obtaining immune reagents and samples from the immune reagent tray and the immune sample feeding channel and adding the immune reagents and the samples into a reaction cup in the immune incubator.

In one embodiment, the immune feed mechanism comprises an immune sample feeding needle and an immune needle cleaning pool, the immune sample feeding needle and the immune needle cleaning pool are arranged on the rack, the immune sample feeding needle can respectively obtain immune reagents and samples from the immune reagent disk and the immune sample feeding channel and add the immune reagents and the samples into reaction cups in the immune incubator, and the immune needle cleaning pool is used for cleaning the immune sample feeding needle.

In one embodiment, the immune loading mechanism further comprises an immune loading arm, a first immune loading driving component and a second immune loading driving component, the immune loading needle is connected to the immune loading arm, the first immune loading driving component is installed in the rack and connected to the immune loading arm, and the first immune loading driving component is used for driving the immune loading arm to rotate in the horizontal direction, so that the immune loading needle is transferred among the immune reagent disk, the immune sampling channel, the immune incubator and the immune needle cleaning pool.

In one embodiment, the reaction cup arrangement mechanism, the reaction cup feeding mechanism, the vortex mixer, the immune incubator, the reading station and the immune magnetic separation and cleaning mechanism are sequentially distributed.

In one embodiment, the reaction cup moving mechanism comprises a first linear guide, a second linear guide, a reaction cup moving seat, a reaction cup gripper, a first moving driving part and a second moving driving part, the first linear guide extends from the reaction cup feeding mechanism to the immunomagnetic separation cleaning mechanism, the reaction cup moving seat is slidably connected to the first linear guide, the first moving driving part is connected to the reaction cup moving seat for driving the reaction cup moving seat to move along the first linear guide, the second linear guide is connected to the reaction cup moving seat and extends along the vertical direction, the reaction cup gripper is slidably connected to the second linear guide, the second moving driving part is mounted on the reaction cup moving seat and is connected to the reaction cup gripper, the second moving driving part is used for driving the reaction cup hand grip to move along the second linear guide piece.

In one embodiment, the reaction cup sorting mechanism comprises a storage bin, a fishing cup component and a sequencing component; the salvaging cup assembly comprises a salvaging cup seat, a salvaging cup chain and a salvaging cup driving part, one part of the salvaging cup chain extends into the stock bin, the other part of the salvaging cup chain extends out of the stock bin, the salvaging cup chain is sequentially connected with a plurality of salvaging cup seats, each salvaging cup seat is provided with a salvaging cup through groove for containing one reaction cup, and the salvaging cup driving part is connected to the salvaging cup chain for driving the salvaging cup chain to move; the sequencing component comprises a sequencing track, a transfer pushing part and a reaction cup transfer driving part, the sequencing track is provided with a sliding chute used for accommodating reaction cups, the feeding end and the discharging end of the sliding chute have a height difference so as to realize the sliding out of the reaction cups, the discharging end of the sliding chute extends to the position of a reaction cup station of the reaction cup feeding mechanism, and the transfer pushing part is used for pushing the reaction cups in the fishing cup through grooves to enter the feeding end of the sliding chute.

In one embodiment, the reaction cup feeding mechanism comprises a feeding turntable and a rotary driving part, the feeding turntable is provided with a plurality of reaction cup stations, the reaction cup stations are distributed at equal intervals along the circumferential direction of the feeding turntable, and the rotary driving part is connected to the feeding turntable and used for driving the feeding turntable to rotate.

In one embodiment, the biochemical analysis device comprises a biochemical feeding mechanism, a biochemical reagent plate, a biochemical incubator, a cleaning mechanism, a stirring mechanism, a detection light source, an optical detection module and an ISE ion detection module; biochemical feed mechanism install in the frame is in order to be used for following biochemical reagent dish and obtain biochemical reagent and sample respectively in the biochemical sampling channel and add to in the reaction ware in the biochemical incubator, rabbling mechanism connect in the frame is in order to be used for stirring the sample in the reaction ware, the testing light source with optics detection module sets up relatively inside and outside in the biochemical incubator are in order to be used for detecting the light signal of reaction ware, ISE ion detection module set up in the frame is in order to be arranged in detecting one or more ion concentration in the sample, wiper mechanism is used for wasing reaction ware in the biochemical incubator.

In one embodiment, the biochemical feeding mechanism comprises a biochemical needle cleaning pool, a biochemical sample adding needle, a biochemical reagent needle and a reagent needle cleaning pool which are arranged on the rack; the biochemical sample adding needle can obtain a sample from the biochemical sample feeding channel and add the sample into a reaction vessel in a biochemical incubator, and the biochemical needle cleaning pool is used for cleaning the biochemical sample adding needle; the biochemical reagent needle can obtain biochemical reagent from the biochemical reagent tray and add the biochemical reagent into a reaction dish in the biochemical incubator, and the reagent needle cleaning pool is used for cleaning the biochemical reagent needle.

In one embodiment, the biochemical loading mechanism further comprises a biochemical loading arm, a first biochemical loading driving component and a second biochemical loading driving component, the biochemical loading needle is connected to the biochemical loading arm, the first biochemical loading driving component is mounted on the frame and connected to the biochemical loading arm, and the first biochemical loading driving component is used for driving the biochemical loading arm to rotate in the horizontal direction so as to realize the transfer of the biochemical loading needle among the immunoassay loading channel, the biochemical incubator and the biochemical needle washing pool;

and/or, biochemical feed mechanism still includes reagent application of sample arm, first reagent application of sample driver part and second reagent application of sample driver part, biochemical reagent needle connect in reagent application of sample arm, first reagent application of sample driver part install in the frame and connect in reagent application of sample arm, first reagent application of sample driver part is used for the drive reagent application of sample arm rotates in the horizontal direction, in order to realize biochemical reagent needle is in biochemical reagent dish, biochemical incubator and transfer between the reagent needle washs the pond.

The sample joint inspection analysis system has the advantages of small structure and high detection speed, can realize multi-item joint inspection based on a biochemical reaction principle and a chemiluminescence detection principle, exerts the test advantages of biochemical reaction and immunoreaction, has no mutual interference of two test modes, can meet the requirements of high-flux and high-sensitivity multi-item joint inspection of various medical treatment and detection mechanisms or units, and simultaneously improves various choices for patients. The biochemical analysis and the immunoassay of the sample joint inspection analysis system are carried out simultaneously, so that the biochemical immune multiple joint inspection with high flux is realized.

In summary, the sample joint inspection analysis system has the following beneficial effects:

(1) the sample processing device provides an immune sample introduction channel and a biochemical sample introduction channel, the biochemical sample introduction channel provides a sample for the biochemical analysis device, and the immune sample introduction channel provides a sample for the chemiluminescence immune analysis device.

(2) The biochemical analysis device reserves a biochemical needle cleaning pool, a biochemical sample adding needle, a biochemical reagent needle, a reagent needle cleaning pool and a stirring mechanism which are required by biochemical reaction, and reserves the characteristics of short reaction time and high flux in the biochemical reaction.

(3) The chemiluminescence immunoassay device reserves a reaction cup arrangement mechanism, a reaction cup feeding mechanism, a vortex mixer, an immunity incubator, a reaction cup moving mechanism, a reading station, an immunity magnetic separation cleaning mechanism, an immunity reagent disc and an immunity feeding mechanism which are required by chemiluminescence reaction, and reserves needle cleaning, reaction magnetic cleaning and darkroom photometric requirements which are required by chemiluminescence reaction high sensitivity.

(4) The sample joint inspection analysis system realizes the presentation of only collecting one vessel of blood, one operation interface and one unified result for one patient.

Drawings

Fig. 1 is a schematic view of a sample joint inspection analysis system according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a sample processing device in the sample joint inspection analysis system shown in FIG. 1;

FIG. 3 is a schematic diagram of an immune feed mechanism in the sample joint inspection analysis system shown in FIG. 1;

FIG. 4 is a schematic view of a cuvette transfer mechanism in the sample joint inspection analysis system shown in FIG. 1;

FIG. 5 is a schematic view of a cuvette sorting mechanism in the sample joint inspection analysis system shown in FIG. 1;

FIG. 6 is a schematic diagram of a first loading mechanism in the sample joint inspection analysis system shown in FIG. 1;

fig. 7 is a schematic diagram of a second loading mechanism in the sample joint inspection analysis system shown in fig. 1.

Description of the reference numerals

10. A sample joint inspection analysis system; 100. a sample processing device; 110. an immunoassay sample injection channel; 120. a biochemical sample introduction channel; 130. a sample feeding bin mechanism; 131. a sample injection seat; 132. a sample introduction frame; 1321. a sample station; 133. a first sample introduction driving part; 134. a second sample introduction driving part; 200. a chemiluminescent immunoassay device; 210. a reaction cup arrangement mechanism; 211. a storage bin; 212. a scoop assembly; 2121. fishing out the cup seat; 21211, a cup dragging through groove; 2122. a cup fishing chain; 2123. a scoop drive component; 213. a sorting component; 2131. Sorting the tracks; 21311. a chute; 2132. a transfer pusher; 2133. a reaction cup transfer drive section; 220. a reaction cup feeding mechanism; 221. a feeding turntable; 2211. a cup-handling station; 222. a rotation driving member; 230. a vortex mixer; 240. an immune incubator; 250. a reaction cup moving mechanism; 251. a first linear guide 252, a second linear guide; 253. a reaction cup moving seat; 254. a gripper of the reaction cup; 255. A first movement driving part; 256. a second movement driving part; 260. a reading station; 270. an immunomagnetic separation cleaning mechanism; 280. an immunoreagent tray; 290. an immunity feeding mechanism; 291. an immune sample injection needle; 292. An immunization needle cleaning pool; 293. an immune sample-adding arm; 294. a first immunoloading drive member; 295. a second immunoloading drive member; 300. a biochemical analysis device; 311. a first feeding mechanism; 3111. a biochemical sample adding needle; 3112. a biochemical needle cleaning tank; 3113. a biochemical sample adding arm; 3114. a first biochemical sample feeding driving part; 3115. a second biochemical sample-adding driving part; 312. a second feeding mechanism; 3121. a biochemical reagent needle; 3122. A reagent needle cleaning pool; 3123. a reagent sample addition arm; 3124. a first reagent loading drive member; 3125. a second reagent loading drive part; 320. a biochemical reagent disk; 330. a cleaning mechanism; 340. a biochemical incubator; 350. A stirring mechanism; 360. detecting a light source; 370. an optical detection module; 380. an ISE ion detection module; 400. a frame; 20. a sample rack; 21. a blood collection tube; 30. a reaction cup; 40. and (4) a reaction dish.

Detailed Description

In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will be able to make similar modifications without departing from the spirit and scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

In the present application, unless expressly stated or limited otherwise, the first feature may be directly on or directly under the second feature or indirectly via intermediate members. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Referring to fig. 1, one embodiment of the present invention provides a sample joint inspection analysis system 10.

Referring to fig. 1, a sample joint inspection analysis system 10 includes a sample processing device 100, a chemiluminescence immunoassay device 200, a biochemical analysis device 300 and a rack 400, wherein the sample processing device 100, the chemiluminescence immunoassay device 200 and the biochemical analysis device 300 are all mounted on the rack 400. The sample processing device 100 includes an immuno-sample channel 110 and a bio-chemical sample channel 120, the immuno-sample channel 110 is connected to the chemiluminescence immuno-analysis device 200, and the bio-chemical sample channel 120 is connected to the bio-chemical analysis device 300.

Because the requirements of biochemical reaction and immunoreaction on for the pollution carrying capacity of the sample adding needle are different, the requirement of immunological sample adding canIs far higher than biochemical sample adding, generally, the cleaning mode of cleaning fluid can be taken in the immunity sample adding to enhance the cleaning effect, and the biochemical sample adding is used for testing Na due to the need⁺、K⁺、Cl^-Generally, adopt the deionized purified water to wash, can not use the washing liquid, therefore, preferably, this embodiment adopts immunity sample introduction channel 110 and 1202 sample introduction channels of biochemical sample introduction channel to add the sample respectively, and two channels can not interfere with each other, have ensured quick, the independent operation of two analytical equipment.

In one embodiment, referring to fig. 2, the sample processing device 100 further comprises a sample inlet bin mechanism 130. Sample bin mechanism 130 includes sample holder 131, sample rack 132, first sample drive unit 133, and second sample drive unit 134. The sample holder 131 is mounted to the rack 400. The sample holder 132 is movably connected to the sample holder 131. The sample rack 132 is provided with a plurality of sample stations 1321 arranged in parallel for placing the sample rack 20. The first sample driving component is connected to the sample rack 132 for driving the sample rack 132 to move along the first direction, and each sample station 1321 can be aligned with the immuno-sample channel 110 and the biochemical sample channel 120, respectively. The second sample driving component 134 is mounted to the sample seat 131 for applying an action to the sample rack 20 in each sample station 1321 to move the sample rack 20 outwards to the immuno-sample channel 110 or the bio-sample channel 120 along the second direction.

In one embodiment, the immuno sample channel 110 is disposed in parallel with the bio-chemical sample channel 120. The first direction is perpendicular to the immuno-sample channel 110 or the bio-chemical sample channel 120. The second direction is parallel to the immuno sample channel 110 or the bio-chemical sample channel 120. For example, the first direction is an X-axis direction within a horizontal plane, and the second direction is a Y-axis direction within the horizontal plane.

In one embodiment, the sample processing device 100 further comprises a barcode scanning mechanism for scanning barcodes of the blood collection tubes 21 attached to the samples in the immuno-sampling channel 110 and the bio-sampling channel 120 to identify the test items to be performed by the blood collection tubes 21. The barcode scanning mechanism is not shown in the drawings.

In one embodiment, the chemiluminescent immunoassay device 200 comprises a cuvette collating mechanism 210, a cuvette feeding mechanism 220, a vortex mixer 230, an immunoablator 240, a cuvette moving mechanism 250, a reading station 260, an immunomagnetic separation washing mechanism 270330, an immunoreagent tray 280, and an immunomeeding mechanism 290. The cuvette collating section 210 is provided to collate and sort the cuvettes 30. The reaction cup feeding mechanism 220 is connected with the reaction cup arranging mechanism 210. The cuvette feed mechanism 220 has a plurality of cuvette 30 stations for receiving cuvettes 30. The cuvette moving mechanism 250 is used to transfer cuvettes 30 between the cuvette feeding mechanism 220, the vortex mixer 230, the immuno-incubator 240, the reading station 260 and the immuno-magnetic separation washing mechanism 270330. The immune feeding mechanism 290 is used for respectively taking immune reagent and sample from the immune reagent tray 280 and the immune sample feeding channel 110 and adding the immune reagent and the sample into the reaction cup 30 in the immune incubator 240.

In one embodiment, referring to fig. 3, the immune feed mechanism 290 includes an immune loading needle 291 and an immune needle washing well 292. The immune sample injection needle 291 and the immune needle cleaning pool 292 are both arranged on the frame 400. The immunoassay needle 291 can take the immunoassay reagent and the sample from the immunoassay reagent tray 280 and the immunoassay sample channel 110, respectively, and add the obtained immunoassay reagent and sample to the cuvette 30 in the immunoassay incubator 240. The immunopen washing reservoir 292 is used to wash the immunoloading needle 291.

In one embodiment, referring to fig. 3, the immune loading mechanism 290 further includes an immune loading arm 293, a first immune loading driving component 294, and a second immune loading driving component 295. The immunoloading needle 291 is connected to the immunoloading arm 293. The first immuno-loading drive member 294 is mounted to the frame 400 and connected to the immuno-loading arm 293. The first immuno-sample driving component 294 is used for driving the immuno-sample arm 293 to rotate in the horizontal direction, so as to realize the transfer of the immuno-sample needle 291 among the immuno-reagent tray 280, the immuno-sample channel 110, the immuno-incubator 240 and the immuno-needle cleaning pool 292.

In one embodiment, the cuvette collating mechanism 210, the cuvette feeding mechanism 220, the vortex mixer 230, the immuno-incubator 240, the reading station 260, and the immuno-magnetic separation cleaning mechanism 270330 are sequentially distributed.

In one embodiment, referring to fig. 4, the cuvette moving mechanism 250 includes a first linear guide, a second linear guide, a cuvette moving base 253, a cuvette hand 254, a first movement driving part 255, and a second movement driving part 256. The first linear guide extends from the cuvette feeder 220 to the immunomagnetic separation washer 270330. The cuvette moving base 253 is slidably coupled to the first linear guide. The first moving driving part 255 is connected to the cuvette moving base 253 for driving the cuvette moving base 253 to move along the first linear guide. The second linear guide is connected to the reaction cup moving seat 253 and extends in a vertical direction, and the reaction cup hand 254 is slidably connected to the second linear guide. The second movement driving part 256 is installed at the cuvette moving base 253 and is connected to the cuvette hand 254. The second movement driving part 256 serves to drive the reaction cup holder 254 to move along the second linear guide. The first linear guide of the reaction cup moving mechanism 250 may be a linear guide. The reaction cup moving mechanism 250 occupies small space and has low cost. It is not difficult to understand. The first linear guide can also be replaced by a rotary path or be designed as a two-dimensional path of movement.

In one embodiment, referring to fig. 5, the cuvette collating mechanism 210 includes a bin 211, a scoop assembly 212, and a sequencing assembly 213. The drag cup assembly 212 includes a drag cup seat 2121, a drag cup chain 2122, and a drag cup drive member 2123. One portion of the drag cup chain 2122 extends into the bin 211 and another portion extends out of the bin 211. A plurality of bailer cup seats 2121 are sequentially connected to the bailer cup chain 2122. The cup holder 2121 has a cup slot 21211 for receiving one of the reaction cups 30. The drag cup driving part 2123 is connected to the drag cup chain 2122 for driving the drag cup chain 2122 to move. The sequencing assembly 213 includes a sequencing track 2131, a transfer pusher 2132, and a cuvette transfer drive assembly 2133. The sequencing rail 2131 has a chute 21311 for receiving a reaction cup 30. The feed end and the discharge end of the chute 21311 have a height difference to enable the reaction cup 30 to slide out. The discharge end of the chute 21311 extends to a position on the reaction cup 30 of the reaction cup feeding mechanism 220. The transfer impeller 2132 is used for pushing the reaction cups 30 in the cup catching through groove 21211 into the feeding end of the chute 21311. The chute 21311 can realize the position adjustment of the reaction cup 30, after the reaction cup 30 enters the chute 21311, the cup mouth of the reaction cup 30 is clamped at the notch of the chute 21311, the cup bottom of the reaction cup 30 falls into the chute 21311 under the action of gravity, so that the arrangement of the head and the tail of the reaction cup 30 is completed, the reaction cup 30 automatically slides into the reaction cup 30 station of the reaction cup feeding mechanism 220 under the action of the height difference of the chute 21311, after the reaction cup 30 station of the reaction cup feeding mechanism 220 is connected with one reaction cup 30, the reaction cup 30 station automatically rotates for a distance of one station, and the empty reaction cup 30 station waits for the next reaction cup 30 to fall. Wherein, the time interval of the rotation of the reaction cup 30 station of the reaction cup feeding mechanism 220 is the same as the time interval of the transfer pushing member 2132. That is, the cup dragging chain 2122 advances once, the transfer pushing element 2132 pushes once, and the reaction cup feeding mechanism 220 rotates once, so as to ensure that the reaction cups 30 sequentially enter the reaction cup feeding mechanism 220. After the transfer pushing member 2132 pushes one reaction cup 30, the reaction cup returns to the initial position, the cup salvaging assembly 212 continues to move upward by one position, and the cup salvaging through groove 21211 of the next cup salvaging seat 2121 is aligned with the transfer pushing member 2132, so that the ordered arrangement of the scattered reaction cups 30 into the reaction cup feeding mechanism 220 is realized.

After the chemiluminescence immunoassay device 200 finishes the analysis, the reaction cup 30 is discarded, so that the reaction cup 30 in the chemiluminescence immunoassay device 200 is a disposable material, and the stock bin 211 needs to be continuously supplemented with new reaction cups 30.

In one embodiment, referring to fig. 5, the cuvette feeding mechanism 220 includes a feeding turntable 221 and a rotation driving part 222. The loading carousel 221 has a plurality of reaction cup 30 stations. The reaction cups 30 are distributed at equal intervals along the circumferential direction of the feeding turntable 221. The rotation driving part 222 is connected to the loading turntable 221 for driving the loading turntable 221 to rotate.

When the chemiluminescence immunoassay device 200 works, firstly, the first linear guide, the second linear guide, the reaction cup moving seat 253, the reaction cup hand 254, the first moving drive component 255 and the second moving drive component 256 of the reaction cup moving mechanism 250 are mutually matched, a single reaction cup 30 is transferred from the reaction cup 30 station of the loading turntable 221 to the immune incubator 240, the immune sample loading arm 293, the first immune sample loading drive component 294 and the second immune sample loading drive component 295 are matched to drive the immune sample loading needle 291 to move, the immune sample loading needle 291 acquires immune reagents from the immune reagent disk 280 and loads the immune reagents into the reaction cups 30 in the immune incubator 240, the immune sample loading needle 291 is cleaned by the immune needle cleaning pool 292, the cleaned immune sample loading needle 291 acquires samples from the blood incubation collecting tube 21 on the samples in the biochemical sample loading channel 120 and loads the samples into the reaction cups 30 in the immune incubator 240, the immuno-needle 291 is washed by the immuno-needle washing cell 292. The reaction cup moving mechanism 250 transfers the reaction cup 30 to the vortex mixer 230 for mixing, and then transfers the reaction cup 30 to the immuno-incubator 240 again, after the sample and the immuno-reagent are incubated and reacted in the immuno-incubator 240, the reaction cup moving mechanism 250 moves the reaction cup 30 to the magnetic separation cleaning mechanism 330, and the magnetic separation cleaning is completed. If the reaction is a one-step reaction, after the magnetic separation cleaning is completed, the reaction cup moving mechanism 250 moves the reaction cup 30 from the magnetic separation cleaning station to the reading station 260, the final optical signal detection is completed through the photoelectric detection of the reading station, and finally the reaction cup 30 after the reaction is finished is discarded. If the reaction is a two-step reaction, after the magnetic separation and washing is completed for the first time, the reaction cup moving mechanism 250 moves the reaction cup 30 from the magnetic separation and washing station back to the immune incubator 240, and after the immune sample adding needle 291 finishes adding the sample and the immune reagent again, the reaction cup 30 is transferred from the immune incubator 240 to the vortex mixer 230 again, and after the mixing is completed on the vortex mixer 230, the reaction cup moving mechanism 250 transfers the reaction cup 30 to the immune incubator 240 again to continue to complete the incubation. After the incubation is finished, the reaction cup moving mechanism 250 moves the reaction cup 30 to the magnetic separation cleaning mechanism 330 to finish the magnetic separation cleaning, after the cleaning is finished, the reaction cup moving mechanism 250 reads the reading station 260 again, and the cup polishing treatment is carried out after the reading, so that the immunoassay of the sample is finished. The sample adding sequence of the immunoreagent and the sample can be adjusted according to needs.

In one embodiment, referring to FIG. 1, the biochemical analyzer 300 includes a biochemical feeding mechanism disposed on a frame 400, a biochemical analyzerThe kit comprises a chemical reagent tray 320, a cleaning mechanism 330, a biochemical incubator 340, a stirring mechanism 350, a detection light source 360, an optical detection module 370 and an ISE ion detection module 380. The biochemical feeding mechanism is installed on the frame 400 for taking biochemical reagent and sample from the biochemical reagent tray 320 and the biochemical sample feeding channel 120, respectively, and adding them into the reaction cuvette 40 in the biochemical incubator 340. The stirring mechanism 350 is connected to the frame 400 for stirring the sample in the reaction cuvette 40. The detection light source 360 is disposed inside and outside the biochemical incubator 340 opposite to the optical detection module 370 for detecting the optical signal of the reaction cuvette 40. An ISE ion detection module 380 is disposed in the rack 400 for detecting one or more ion concentrations in the sample. The ISE ion detection block 380 may be used to detect Na in a sample⁺、K⁺、Cl^-If the ion detection is performed on the sample, the biochemical feeding mechanism directly discharges the sample into the ISE ion detection module 380 for ion detection, and does not need to discharge into the reaction cuvette 40 of the biochemical incubator 340. The cleaning mechanism 330 is installed on the frame 400 and located above the biochemical incubator 340, and the cleaning mechanism 330 is used for cleaning the reaction cuvette 40 in the biochemical incubator 340.

In one embodiment, the biochemical feeding mechanism includes a first feeding mechanism 311 and a second feeding mechanism 312.

The first feeding mechanism 311 includes a biochemical needle cleaning tank 3112 and a biochemical sample adding needle 3111 disposed on the rack 400; the second loading mechanism 312 includes a biochemical reagent needle 3121 disposed on the rack 400 and a reagent needle washing bath 3122. The biochemical sample feeding needle 3111 can take sample from the biochemical sample feeding channel 120 and feed the sample into the reaction vessel 40 in the biochemical incubator 340. The biochemical needle cleaning tank is used for cleaning the biochemical sampling needle 3111. The biochemical reagent needle 3121 can take biochemical reagent from the biochemical reagent tray 320 and add the biochemical reagent to the reaction cuvette 40 in the biochemical incubator 340. The reagent needle cleaning bath 3122 is used to clean the biochemical reagent needles 3121.

In one embodiment, the biochemical sample injection needle 3111 and the biochemical reagent needle 3121 can be used in combination, that is, they share a needle. However, since biochemical reactions are generally faster and the test speed is often limited by using the same needle, it is preferable to use the biochemical sample injection needle 3111 and the biochemical reagent needle 3121 separately.

In one embodiment, referring to fig. 6, the first loading mechanism 311 includes a biochemical sample loading arm 3113, a first biochemical sample loading driving part 3114 and a second biochemical sample loading driving part 3115. The biochemical sample addition needle 3111 is connected to the biochemical sample addition arm 3113. The first biochemical sample application driving unit 3114 is attached to the frame 400 and connected to the biochemical sample application arm 3113. The first biochemical sample feeding driving part 3114 is configured to drive the biochemical sample feeding arm 3113 to rotate in a horizontal direction, so as to transfer the biochemical sample feeding needle 3111 among the immuno sample feeding channel 110, the biochemical incubator 340, and the biochemical needle cleaning pool 3112.

In one embodiment, referring to fig. 7, the second loading mechanism 312 comprises a reagent loading arm 3123, a first reagent loading driving member 3124, and a second reagent loading driving member 3125. The biochemical reagent needle 3121 is connected to the reagent sample addition arm 3123. The first reagent loading drive member 3124 is attached to the frame 400 and connected to the reagent loading arm 3123. The first reagent loading driving part 3124 is used to drive the reagent loading arm 3123 to rotate in the horizontal direction, so as to realize the transfer of the biochemical reagent needle 3121 between the biochemical reagent tray 320, the biochemical incubator 340, and the reagent needle cleaning chamber 3122.

The reaction cuvette 40 used in the biochemical analysis apparatus 300 is washable and recyclable to reduce the use cost, and the reaction cuvette 40 is generally a permanent quartz glass reaction cup 30. The reaction cuvette 40 is fixed on the biochemical incubator 340, and is rotatably moved to the lower part of each component of the biochemical analysis apparatus 300 by the biochemical incubator 340, and no additional equipment is needed for transferring the position of the reaction cuvette 40. The biochemical incubator 340 provides a constant temperature environment to the reaction dish 40, generally set at a constant temperature of 37 ℃.

When the biochemical analyzer 300 is used, the cleaning mechanism 330 cleans the reaction cuvette 40 in the biochemical incubator 340 for a plurality of times, and sucks the liquid in the reaction cuvette 40 to make it clean, so that the reaction cuvette 40 can be used for a new reaction. The clean reaction cuvette 40 is cleaned and is advanced periodically, for example, by rotating the biochemical incubator 340, and when the clean reaction cuvette is advanced to a position under the track line of the biochemical probe 3111, the biochemical probe 3111 sucks the sample from the blood collection tube 21 on the sample holder 20 in the biochemical sample channel 120 and transfers the sample to the reaction cuvette 40. The reaction interior continues to advance according to the period, rotates to the position below the track of the biochemical reagent needle 3121, and the biochemical reagent needle 3121 sucks the biochemical reagent from the biochemical reagent bottle in the biochemical reagent tray 320 and transfers the biochemical reagent to the reaction vessel 40. The reaction cuvette 40 with the biochemical reagents and the sample is rotated to a position below the stirring mechanism 350 for uniformly stirring. The well-stirred and mixed reaction vessel 40 performs incubation reaction in the biochemical incubator 340, and the reaction vessel 40 performs photoelectric data acquisition through the optical detection module 370 in each measurement period. The reaction cuvette 40 after the reaction is circulated back to the lower part of the cleaning mechanism 330, and the cleaning mechanism 330 again cleans the reaction cuvette 40 for a plurality of times, so that the reaction cuvette 40 can be recycled.

The biochemical sample injection needle 3111 is firstly cleaned on the inner and outer walls in the biochemical needle cleaning pool 3112, after cleaning, the biochemical sample injection needle 3111 rotates to the biochemical sample injection channel 120, the sample is sucked from the blood collection tube 21 and transferred to the reaction vessel 40 corresponding to the biochemical incubator 340, if Na is carried out, the sample is put into the reaction vessel 40 corresponding to the biochemical incubator 340⁺、K⁺、Cl^-The biochemical sample feeding needle 3111 directly transfers the sample to the ISE ion detection module 380 for detection without transferring to the reaction vessel 40.

The biochemical reagent needle 3121 firstly cleans the inner and outer walls of the needle in the reagent needle cleaning pool 3122, after cleaning, the biochemical reagent needle 3121 rotates to the biochemical reagent tray 320, the biochemical reagent tray 320 rotates the reagent box to be tested to the track of the biochemical reagent needle 3121, the biochemical reagent needle 3121 sucks the needed biochemical reagent and transfers the reagent box to the reaction cup 30, and biochemical reaction is carried out. In case of two-step reaction, when the biochemical reagent is added at the 2 nd time, the reaction cuvette 40 rotates back to the lower side of the biochemical reagent needle 3121 again, and the biochemical reagent needle 3121 transfers the biochemical reagent of the 2 nd component into the reaction cuvette 40 for reaction. The biochemical reagent needles 3121 may have two groups, and the two groups of biochemical reagent needles 3121 perform the sample application and division of the 1 st component and the 2 nd component, so that the whole biochemical reaction speed is increased. From the cost and space savings and the customer demand location for testing speed, the sample application of component 1 and component 2 may be performed using only one set of biochemical reagent needles 3121. Wherein, the sample adding sequence of the biochemical reagent and the sample can be adjusted according to the requirement.

Example 1

The embodiment provides a sample joint inspection analysis method.

The sample joint inspection analysis method of the present embodiment uses the sample joint inspection analysis system 10 described above. In this embodiment, the operation process of the sample joint inspection analysis system 10 is described in detail by taking three joint inspections, namely C-reactive protein (CRP), serum amyloid a (saa), and Procalcitonin (PCT), in infectious diseases as examples; wherein PCT is detected by the chemiluminescent immunoassay device 200 of the chemiluminescent immunoassay device 200, and CRP and SAA are biochemical test items detected by immunoturbidimetric assay.

Referring to fig. 1, after blood of a patient is drawn into a blood collection tube 21, centrifuged to remove the cover, and placed in a sample rack 20, the sample rack 20 is placed in a sample station 1321 of a sample chamber mechanism 130, and a sensor (not labeled) detects that the sample rack 20 is located at the sample station 1321, a first sample driving part drives the sample rack 132 to move along an X-axis, so that a corresponding chamber can be aligned to an immuno-sample channel 110 or a biochemical sample channel 120. The barcode scanning mechanism scans the barcode of the blood collection tube 21 added to the sample in the immuno-sampling channel 110 or the biochemical sampling channel 120, identifies the test item to be performed by the blood collection tube 21, and obtains 3 items of test signals CRP, SAA, and PCT through the barcode.

The sample joint inspection analysis system 10 determines which item test is performed first according to how busy the immuno-luminescence analysis device and the biochemical analysis device 300 are, and assumes that the test of PCT is performed first. The second sample driving component 134 acts on the sample rack 20 in the sample station 1321 to move the sample rack 20 outwards along the Y-axis direction into the immunoassay sample channel 110 and transmit the sample rack to the lower part of the track of the immunoassay sample injection needle 291. Meanwhile, the cuvette arranging mechanism 210 arranges the cuvettes 30 in an ordered arrangement, and arranges the ordered cuvettes 30 one by one in the cuvette feeding mechanism 220. The cuvette 30 transferring mechanism grabs a new cuvette 30 from the cuvette feeding mechanism 220 and transfers it to a certain incubation hole of the immuno-incubator 240, and after the immuno-loading needle 291 is washed in the immuno-washing cell, the corresponding sample is sucked from the blood collection tube 21 and transferred to and discharged from the cuvette 30 of the immuno-incubator 240. After the sample required by the immune reaction of the PCT is completely sucked, the sample rack 20 is retracted into the sample rack 132, the sample rack 132 is aligned with the biochemical sample channel 120 again, and the blood collection tube 21 is transferred into the biochemical sample channel 120.

The cuvette 30, to which the sample has been added, in the immuno-incubator 240 continues to suck the immuno-reagent from the reagent cassette in the immuno-reagent tray 280 by the washed immuno-loading needle 291 and transfer it to this cuvette 30. The reaction cup 30 added with the immune reagent is transferred to the vortex mixer 230 by the reaction cup 30 transfer mechanism to be mixed evenly in a vortex mode, and after the mixing is finished, the reaction cup 30 is transferred to the immune incubator 240 by the reaction cup 30 transfer mechanism to be incubated and reacted under the constant temperature condition. After the incubation reaction for a predetermined time, the cuvette 30 is moved to the magnetic separation washing station by the cuvette 30 transfer mechanism, and magnetic separation washing is performed. After the completion of the washing, the reaction cuvette 30 is transferred to the reading station 260 by the transfer mechanism, and the detection of the luminescence signal is performed, whereby the concentration of PCT is measured.

On the other hand, the blood collection tube 21 has been transferred to the biochemical sample channel 120, and the biochemical incubator 340 rotates and is washed by the washing mechanism 330 for multiple times to obtain at least 2 clean reaction vessels 40. The 2 reaction vessels 40 are sequentially rotated and advanced to the lower side of the track of the biochemical needle 3111, and the amounts of samples necessary for the two items of CRP and SAA are added through the biochemical needle 3111. Then the 2 reaction dishes 40 continue to advance to reach the lower part of the track of the biochemical reagent needle 3121 in sequence, the biochemical reagent needle 3121 after cleaning sucks biochemical reagents required by the reaction from the CRP and SAA reagent bottles in the biochemical reagent tray 320 respectively and adds the biochemical reagents into the 2 reaction dishes 40 respectively, and the 2 reaction dishes 40 continue to rotate and advance to the lower part of the stirring mechanism 350, so that the stirring and the uniform mixing of the sample and the biochemical reagents are completed. After the mixture is uniformly mixed, the raw melon is incubated in a raw melon incubator for reaction, the optical detection module 370 is used for collecting and detecting photoelectric signals, and the detection of two items of CRP and SAA is completed by a turbidimetry method. After the 3 project detections are finished, the detection result is transmitted and fed back to the patient in a report list or Lis information system mode, so that one vessel of blood, one operation mode and one uniform result multi-project joint detection are realized.

The sample joint inspection analysis system 10 has a miniaturized structure and high detection speed, can realize multi-project joint inspection based on a biochemical reaction principle and a chemiluminescence detection principle, exerts the testing advantages of biochemical reaction and immunoreaction, has no mutual interference of two testing modes, can meet the requirements of high-flux and high-sensitivity multi-joint inspection of various medical treatment, detection mechanisms or units, and simultaneously improves various choices for patients. The biochemical analysis and the immunoassay of the sample joint inspection analysis system 10 are performed simultaneously, so that the biochemical immune multiple joint inspection with high flux is realized.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (10)

1. The utility model provides a sample joint inspection analytic system, its characterized in that, including the frame and set up in sample processing device, chemiluminescence immunoassay device, biochemical analysis device in the frame, sample processing device includes immunity introduction channel and biochemical introduction channel, immunity introduction channel with chemiluminescence immunoassay device intercommunication, biochemical introduction channel with biochemical analysis device intercommunication.

2. The sample joint inspection analysis system of claim 1, wherein the sample processing device further comprises a sample introduction bin mechanism, the sample feeding bin mechanism comprises a sample feeding seat, a sample feeding frame, a first sample feeding driving part and a second sample feeding driving part, the sample injection seat is arranged on the frame, the sample injection frame is movably connected with the sample injection seat, a plurality of sample stations for placing the sample frame are arranged on the sample injection frame in parallel, the first sample introduction driving part is connected with the sample introduction frame and used for driving the sample introduction frame to move along a first direction, each sample station can be respectively aligned with the immunity sample introduction channel and the biochemistry sample introduction channel, the second sample injection driving part is arranged on the sample injection seat and used for exerting actions on the sample rack in each sample station so as to enable the sample rack to move outwards to the immune sample injection channel or the biochemical sample injection channel along a second direction.

3. The system according to claim 1, wherein the chemiluminescence immunoassay device comprises a reaction cup arrangement mechanism, a reaction cup feeding mechanism, a vortex mixer, an immunity incubator, a reaction cup moving mechanism, a reading station, an immunity magnetic separation cleaning mechanism, an immunity reagent disk and an immunity feeding mechanism, wherein the reaction cup arrangement mechanism is used for arranging and sequencing reaction cups, the reaction cup feeding mechanism is connected with the reaction cup arrangement mechanism, the reaction cup feeding mechanism is provided with a plurality of reaction cup stations for accommodating the reaction cups, the reaction cup moving mechanism is used for transferring the reaction cups among the reaction cup feeding mechanism, the vortex mixer, the immunity incubator, the reading station and the immunity magnetic separation cleaning mechanism, and the immunity feeding mechanism is used for respectively obtaining immunity reagents and samples from the immunity reagent disk and the immunity sample feeding channel and adding the immunity reagents and the samples into the immunity incubator A reaction cup in the incubator.

4. The system for combined sample inspection and analysis according to claim 3, wherein the immune feeding mechanism comprises an immune loading needle and an immune needle cleaning pool, the immune loading needle and the immune needle cleaning pool are both disposed on the rack, the immune loading needle can respectively obtain immune reagents and samples from the immune reagent tray and the immune sample feeding channel and add the immune reagents and samples into reaction cups in an immune incubator, and the immune needle cleaning pool is used for cleaning the immune loading needle;

and/or the reaction cup arrangement mechanism, the reaction cup feeding mechanism, the vortex mixer, the immune incubator, the reading station and the immune magnetic separation cleaning mechanism are sequentially distributed;

and/or the reaction cup arrangement mechanism comprises a stock bin, a fishing cup component and a sequencing component; the salvaging cup assembly comprises a salvaging cup seat, a salvaging cup chain and a salvaging cup driving part, one part of the salvaging cup chain extends into the stock bin, the other part of the salvaging cup chain extends out of the stock bin, the salvaging cup chain is sequentially connected with a plurality of salvaging cup seats, each salvaging cup seat is provided with a salvaging cup through groove for containing one reaction cup, and the salvaging cup driving part is connected to the salvaging cup chain for driving the salvaging cup chain to move; the sequencing component comprises a sequencing track, a transfer pushing part and a reaction cup transfer driving part, the sequencing track is provided with a sliding chute used for accommodating reaction cups, the feeding end and the discharging end of the sliding chute have a height difference so as to realize the sliding out of the reaction cups, the discharging end of the sliding chute extends to the position of a reaction cup station of the reaction cup feeding mechanism, and the transfer pushing part is used for pushing the reaction cups in the fishing cup through grooves to enter the feeding end of the sliding chute.

5. The system of claim 4, wherein the immuno-loading mechanism further comprises an immuno-loading arm, a first immuno-loading driving member, and a second immuno-loading driving member, the immuno-loading needle is connected to the immuno-loading arm, the first immuno-loading driving member is mounted to the frame and connected to the immuno-loading arm, and the first immuno-loading driving member is configured to drive the immuno-loading arm to rotate in a horizontal direction, so as to transfer the immuno-loading needle between the immuno-reagent disk, the immuno-loading channel, the immuno-incubator, and the immuno-needle washing chamber.

6. The system for joint sample analysis according to claim 4, wherein the cuvette moving mechanism comprises a first linear guide extending from the cuvette feeding mechanism to the immunomagnetic separation washing mechanism, a second linear guide, a cuvette moving base slidably connected to the first linear guide, a cuvette hand connected to the cuvette moving base for driving the cuvette moving base to move along the first linear guide, a first moving driving part connected to the cuvette moving base and extending in a vertical direction, and a second moving driving part slidably connected to the second linear guide, the second moving driving part being mounted to the cuvette moving base and connected to the cuvette hand, the second moving driving part is used for driving the reaction cup hand grip to move along the second linear guide piece.

7. The system for the joint sample analysis according to claim 4, wherein the cuvette feeding mechanism comprises a feeding turntable and a rotary driving member, the feeding turntable has a plurality of cuvette stations, the cuvette stations are distributed at equal intervals along the circumferential direction of the feeding turntable, and the rotary driving member is connected to the feeding turntable for driving the feeding turntable to rotate.

8. The sample joint inspection analysis system of any one of claims 1-7, wherein the biochemical analysis device comprises a biochemical feeding mechanism, a biochemical reagent tray, a cleaning mechanism, a biochemical incubator, a stirring mechanism, a detection light source, an optical detection module, and an ISE ion detection module; biochemical feed mechanism install in the frame is in order to be used for following biochemical reagent dish and obtain biochemical reagent and sample respectively in the biochemical sampling channel and add to in the reaction ware in the biochemical incubator, rabbling mechanism connect in the frame is in order to be used for stirring the sample in the reaction ware, the testing light source with optics detection module sets up relatively inside and outside in the biochemical incubator are in order to be used for detecting the light signal of reaction ware, ISE ion detection module set up in the frame is in order to be arranged in detecting one or more ion concentration in the sample, wiper mechanism is used for wasing reaction ware in the biochemical incubator.

9. The system for combined sample analysis according to claim 8, wherein the biochemical feeding mechanism comprises a biochemical needle cleaning tank, a biochemical sample adding needle, a biochemical reagent needle and a reagent needle cleaning tank arranged on the frame; the biochemical sample adding needle can obtain a sample from the biochemical sample feeding channel and add the sample into a reaction vessel in a biochemical incubator, and the biochemical needle cleaning pool is used for cleaning the biochemical sample adding needle; the biochemical reagent needle can obtain biochemical reagent from the biochemical reagent tray and add the biochemical reagent into a reaction dish in the biochemical incubator, and the reagent needle cleaning pool is used for cleaning the biochemical reagent needle.

10. The system of claim 9, wherein the biochemical loading mechanism further comprises a biochemical loading arm, a first biochemical loading driving component and a second biochemical loading driving component, the biochemical loading needle is connected to the biochemical loading arm, the first biochemical loading driving component is mounted on the frame and connected to the biochemical loading arm, and the first biochemical loading driving component is used for driving the biochemical loading arm to rotate in a horizontal direction so as to realize the transfer of the biochemical loading needle among the immunoassay sampling channel, the biochemical incubator and the biochemical needle washing tank;

and/or, biochemical feed mechanism still includes reagent application of sample arm, first reagent application of sample driver part and second reagent application of sample driver part, biochemical reagent needle connect in reagent application of sample arm, first reagent application of sample driver part install in the frame and connect in reagent application of sample arm, first reagent application of sample driver part is used for the drive reagent application of sample arm rotates in the horizontal direction, in order to realize biochemical reagent needle is in biochemical reagent dish, biochemical incubator and transfer between the reagent needle washs the pond.

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