CN218546775U

CN218546775U - Automatic analyzer

Info

Publication number: CN218546775U
Application number: CN202222873014.7U
Authority: CN
Inventors: 黄泳; 王晶
Original assignee: Shenzhen Wujiang Life Science Co ltd
Current assignee: Shenzhen Wujiang Life Science Co ltd
Priority date: 2022-10-28
Filing date: 2022-10-28
Publication date: 2023-02-28
Anticipated expiration: 2032-10-28

Abstract

The utility model relates to a chemiluminescence detects technical field, especially relate to an automatic analytical equipment, wherein, automatic analytical equipment includes application of sample dish unit, sample application of sample unit, reagent adds the unit, the reaction scheduling unit, the cleaning unit, photometry unit and reaction cup transfer unit, application of sample reaction dish can drive application of sample and hold in the palm cup structure and go up the cup position through the application of sample in proper order when rotating, at least one row liquid level and application of sample operation position, the reaction scheduling unit, including reaction incubation dish and dial plate, reaction incubation dish and dial plate independently rotate separately, reaction cup transfer unit includes first transfer tongs, second transfer tongs and third transfer tongs. The sample feeding reaction disc, the reaction incubation disc and the adjusting disc are dispatched in a rotating mode, and the first transfer gripper, the second transfer gripper and the third transfer gripper are transferred in a matched mode, so that the testing flux of the automatic analysis device is improved.

Description

Automatic analyzer

Technical Field

The utility model relates to a chemiluminescence detects technical field, especially relates to an automatic analysis device.

Background

The chemiluminescence immune analysis method is an in vitro detection analysis technology combining antigen-antibody immune reaction and luminescence reaction, which is based on the immunological theory, takes a luminescence marker as a tracing signal, and detects various markers by collecting light signals, and has the advantages of high sensitivity, low nonspecific adsorption and high accuracy.

Currently, automatic analyzers based on chemiluminescence immunoassay have become mature medical diagnosis equipment, however, currently, most automatic analyzers have low single-unit test flux and cannot meet the requirement of a large number of clinical sample tests, so that the work efficiency of users who need to diagnose according to sample measurement results, such as doctors, is seriously affected.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome above-mentioned prior art not enough, provide an automatic analysis device, it aims at solving the lower problem of test flux.

The utility model discloses a realize like this:

an automated analysis device comprising:

the sample adding tray unit comprises a sample adding reaction tray, the sample adding reaction tray rotates around a rotating axis, the sample adding reaction tray is provided with a plurality of sample adding supporting cup structures for supporting reaction cups, each sample adding supporting cup structure surrounds the rotating axis and is arranged at equal intervals, and the sample adding reaction tray can drive the sample adding supporting cup structures to sequentially pass through a sample adding cup position, at least one liquid discharging position and a sample adding operation position when rotating;

the sample adding unit can suck a sample from the sample supply unit and add the sample to the reaction cup positioned at the liquid discharging level;

a reagent adding unit capable of sucking a reagent from the reagent supplying unit and adding the reagent to a reaction cup located at one of the discharge levels;

the reaction incubation disc and the scheduling disc rotate around the same rotation axis respectively and independently, the reaction incubation disc is provided with a plurality of reaction incubation supporting cup structures used for supporting reaction cups, each reaction incubation supporting cup structure surrounds the rotation axis and is arranged at equal intervals, the reaction incubation disc can drive the reaction incubation supporting cup structures to at least pass through a reaction incubation transfer A position, a reaction incubation transfer B position and a reaction incubation transfer C position when rotating, the scheduling disc is provided with a plurality of scheduling supporting cup structures used for supporting the reaction cups, each scheduling supporting cup structure surrounds the rotation axis and is arranged at equal intervals, and the scheduling disc can drive the scheduling supporting cup structures to at least pass through a scheduling transfer A position, a scheduling transfer B position and a scheduling transfer C position when rotating;

the washing unit is used for washing away the sample and the reagent which are not combined and reacted in the reaction cup;

the photometric unit is used for measuring the light intensity of the reaction liquid in the reaction cup;

the reaction cup transferring unit comprises a first transferring hand grip, a second transferring hand grip and a third transferring hand grip, the first transferring hand grip can transfer the reaction cups among the sample adding operation position, the reaction incubation transferring A position and the scheduling transferring A position, the second transferring hand grip can transfer the reaction cups among the reaction incubation transferring B position, the scheduling transferring B position and the cleaning unit, and the third transferring hand grip can transfer the reaction cups among the reaction incubation transferring C position, the scheduling transferring C position, the photometric unit and the photometric polishing cup position.

By last knowing, based on the utility model discloses a structural design, at first, through application of sample reaction dish, the dispatch of the rotation mode of dish and dial plate is hatched in the reaction, can enough simplify the structure that the reaction cup shifted the unit, the first tongs that shifts of deuterogamying, the second shifts the transferring of tongs and third transfer tongs, can carry out one-step process test or two-step method test to the sample fast, improve automatic analysis device's test flux effectively, secondly, dish and dial plate are hatched in the reaction and the environment is hatched in the same use, be favorable to simplifying automatic analysis device's structure.

Furthermore, based on the utility model discloses, can also carry out the test flow of multiple difference, can satisfy multiple different test demands.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required to be used in the embodiments will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

Fig. 1 is a schematic structural diagram of the present automatic analyzer according to an embodiment of the present invention;

fig. 2 is a flow chart of an automatic analysis method of a one-step test according to an embodiment of the present invention;

fig. 3 is a flowchart of an automatic analysis method of a two-step test according to an embodiment of the present invention.

The reference numbers illustrate:

reference numerals	Name(s)	Reference numerals	Name (R)
				100	Sample adding disk unit
110	Sample adding reaction disc	120	Dilution tray
				200	Reaction cup supply unit
310	Sample supply unit	311	Sample rack
				320	Quality control unit
400	Sample adding unit
				510	Reagent addition unit	520	Reagent supply unit
600	Reaction scheduling unit
				610	Reaction incubation disc	620	Adjustable dial
700	Cleaning unit
				800	Photometric unit
810	Optical disk	820	Light measuring instrument
				910	First transfer gripper	920	Second transfer gripper
930	Third transfer gripper

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It should be noted that the terms of left, right, upper and lower directions in the embodiments of the present invention are only relative concepts or are referred to the normal use state of the product, and should not be considered as limiting.

Referring to fig. 1, the present invention provides an automatic analyzer, which includes a sample adding tray unit 100, a sample adding unit 400, a reagent adding unit 510, a reaction scheduling unit 600, a cleaning unit 700, a photometric unit 800, and a cuvette transfer unit.

Specifically, the sample application tray unit 100 includes a sample application and reaction tray 110. The sample application and reaction plate 110 is rotated about a rotation axis. The sample adding reaction disc 110 is provided with a plurality of sample adding support cup structures for supporting reaction cups, each sample adding support cup structure surrounds the rotating axis and is arranged at equal intervals, and the sample adding reaction disc 110 can drive the sample adding support cup structures to sequentially pass through a sample adding cup position, at least one liquid discharging position and a sample adding operation position when rotating; it should be noted that, the position of the cup position and the position of the sample-adding operation position may be overlapped, that is, the cup position and the sample-adding operation position are at the same position, or may be spaced, that is, the cup position and the sample-adding operation position are not at the same position; in addition, when one sample loading cup structure is removed from the sample loading cup position, the other sample loading cup structure can be moved to the sample loading cup position.

The sample application unit 400 can suck a sample from the sample supply unit 310 and apply the sample to reaction cups located at a row of liquid levels. The utility model discloses in the concrete implementation, preferably, this unit of application of sample includes sampling needle, sampling needle actuating mechanism and sampling needle wiper mechanism, and this unit of application of sample's concrete action flow is as follows: the sampling needle driving mechanism drives the sampling needle to move from the sampling needle cleaning mechanism to the position above a sample tube on the sample rack 311, then the sampling needle vertically moves downwards to the sample tube to absorb a certain amount of samples, then the sampling needle vertically moves upwards and then moves to a reaction cup positioned at a row of liquid levels to discharge a certain amount of samples, finally the sampling needle vertically moves upwards and is drawn out from the reaction cup, and at the moment, the sampling needle driving mechanism drives the sampling needle to move to the sampling needle cleaning mechanism to clean the inner wall and the outer wall of the sampling needle.

The reagent adding unit 510 can suck the reagent from the reagent supply unit 520 and add the reagent to the reaction cup located at a row of liquid levels. In the present embodiment, preferably, the reagent adding unit 510 includes a reagent needle, a reagent needle driving mechanism, and a reagent needle cleaning mechanism, and the specific operation flow of the reagent adding unit 510 is as follows: the reagent needle driving mechanism drives the reagent needle to move from the reagent needle cleaning mechanism to the reagent supply unit 520, then the reagent needle vertically moves downwards to the reagent supply unit 520 to suck a certain amount of samples, then the reagent needle vertically moves upwards and then moves to a reaction cup positioned at a row of liquid levels to discharge a certain amount of reagents, finally the reagent needle vertically moves upwards and is drawn out from the reaction cup, and at the moment, the reagent needle driving mechanism drives the reagent needle to move to the reagent needle cleaning mechanism to clean the inner wall and the outer wall of the reagent needle; here, if the reagent adding unit 510 needs to suck the same reagent at the next time, the reagent may not be washed. In the embodiment of the present invention, preferably, two reagent supplying units 520 are provided, the two reagent supplying units 520 work independently of each other, the two reagent adding units 510 are provided, and the two reagent supplying units 520 are respectively provided corresponding to the two reagent adding units 510 one by one, so that the reagent adding units 510 can operate alternately or simultaneously to improve the testing efficiency; it should be noted here that the position where the sample is added by the sample adding unit 400 and the position where the reagent is added by the reagent adding unit 510 may be at the same liquid discharge level, at this time, the sample adding unit 400 and the reagent adding unit 510 alternately operate on the same cuvette, or may be at different liquid discharge levels, at this time, the sample adding unit 400 and the reagent adding unit 510 may operate on two different cuvettes simultaneously, and the operation efficiency may be improved.

The reaction scheduling unit 600 is a place where a sample and a reagent reaction solution fully react, and specifically, the reaction scheduling unit 600 includes a reaction incubation tray 610 and a modulation tray 620, the reaction incubation tray 610 and the modulation tray 620 rotate independently around the same rotation axis, the reaction incubation tray 610 has a plurality of reaction incubation cup supporting structures for supporting reaction cups, each reaction incubation cup supporting structure surrounds the rotation axis and is arranged at equal intervals, the reaction incubation tray 610 can drive the reaction incubation cup supporting structures to transfer a position, a reaction incubation transfer B position and a reaction incubation transfer C position at least through reaction incubation when rotating, the modulation tray 620 has a plurality of scheduling cup supporting structures for supporting reaction cups, each scheduling cup supporting structure surrounds the rotation axis and is arranged at equal intervals, and the modulation tray 620 can drive the scheduling cup supporting structures to transfer at least the a position, the scheduling transfer B position and the scheduling transfer C position when rotating; in the embodiment of the present invention, preferably, the reaction incubation disc 610 and the adjustment disc 620 together have a disc structure, wherein the reaction incubation disc 610 has an annular shape, the adjustment disc 620 has a disc structure and is disposed inside the reaction incubation disc 610, and the adjustment disc 620 is nested inside the reaction incubation disc 610, so as to facilitate reducing the size of the reaction scheduling unit 600; it should be noted that, the reaction incubation tray 610 and the adjustment tray 620 may be used alternatively, that is, the reaction incubation tray 610 is used as the adjustment tray 620, and the adjustment tray 620 is used as the reaction incubation tray 610, specifically, the reaction incubation transfer a site, the reaction incubation transfer B site, and the reaction incubation transfer C site are respectively and correspondingly replaced with the scheduling transfer a site, the scheduling transfer B site, and the scheduling transfer C site.

The washing unit 700 is used for washing away the sample and the reagent which are not combined and reacted in the reaction cup; it should be noted that, after the washing unit 700 is used to wash away the sample and the reagent that are not combined with the reaction in the cuvette, whether to inject the substrate solution into the cuvette may be selected according to the requirement.

The photometric unit 800 is used to measure the light intensity of the reaction solution in the reaction cup, and by measuring the difference in light intensity emitted by the substances to be measured with different concentrations, a curve of concentration and luminous intensity is established, and by the curve, the concentration content of the substance to be measured in the sample is calculated. In the implementation of the present invention, preferably, the photometric unit 800 includes a photometric disk 810, a photometric instrument 820, a waste liquid absorbing mechanism, and an excitation liquid injecting mechanism; the light measuring disc 810 is of a disc type structure and is provided with a light measuring support cup structure for supporting the reaction cup; the photometer 820 is used for measuring the final reaction of the reaction cup; the waste liquid absorbing mechanism is arranged above the optical disk 810 and is used for absorbing liquid finally reacted in the reaction cup; the excitation liquid injection mechanism is used for injecting excitation liquid capable of exciting to emit light into the reaction cup before the light intensity of the reaction cup is measured, namely, the excitation liquid is added before the light is measured, and the excitation reaction liquid emits certain light intensity, so that the light measuring instrument 820 can conveniently measure the light intensity; in addition, it should be noted that, in other embodiments, the cleaning unit 700 and the light measuring unit 800 may be disposed independently from each other, or may jointly form a cleaning light measuring structure, and the cleaning unit 700 and the light measuring unit 800 share a partial structure, for example, may share a driving disc.

The reaction cup transfer unit is used for transferring the reaction cup among the components. Specifically, the cuvette transfer unit includes a first transfer grip 910, a second transfer grip 920, and a third transfer grip 930, the first transfer grip 910 is capable of transferring cuvettes between the loading operation position, the reaction incubation transfer a position, and the scheduled transfer a position, the second transfer grip 920 is capable of transferring cuvettes between the reaction incubation transfer B position, the scheduled transfer B position, and the washing unit 700, and the third transfer grip 930 is capable of transferring cuvettes between the reaction incubation transfer C position, the scheduled transfer C position, the photometric unit 800, and the photometric cuvette polishing position.

Of course, it should be noted that, in the embodiment of the present invention, the automatic analyzer further includes a control unit, and the control unit is used to control the operation and action sequence of the sample adding tray unit 100, the cuvette supplying unit 200, the sample adding unit 400, the reagent adding unit 510, the reaction scheduling unit 600, the cleaning unit 700, the photometric unit 800, and the cuvette transferring unit.

Based on the utility model discloses a structural design, as shown in fig. 2, its automatic analysis step that realizes the one-step method test is as follows:

one-step reagent addition: sample adding and reaction disc 110 rotates to drive the sample adding and holding cup structure to start from the cup position in the sample adding process and sequentially pass through each row of liquid levels, and the liquid level is transferred to the sample adding operation position, wherein the reaction cup supply unit 200 places the reaction cup in the cup position in the sample adding process to the sample adding and holding cup structure, the sample adding unit 400 absorbs the sample from the sample supply unit 310 and adds the sample to the reaction cup, and the reagent adding unit 510 absorbs the reagent from the reagent supply unit 520 and adds the reagent to the reaction cup.

In this step, the addition of the sample and the reagent is completed, and a reaction solution is formed.

It should be noted that, in this step, before the sample-loading reaction plate 110 rotates, the sample-loading cup structure located at the position of the sample-loading cup holds a reaction cup.

One-step reagent incubation: the first transferring hand 910 transfers the reaction cup from the sample loading operation position to the reaction incubation transfer position a, and after a certain incubation time, the reaction incubation tray 610 rotates and drives the reaction incubation cup holder structure to move from the reaction incubation transfer position a to the reaction incubation transfer position B.

In this case, the reaction solution is incubated in this step.

Cleaning and separating: the second transfer grip 920 transfers the cuvette from the reaction incubation transfer B site to the washing unit 700, and the washing unit 700 washes away the unbound and reacted sample and reagent in the cuvette.

Measuring light intensity: the second transfer hand grip 920 transfers the reaction cup from the cleaning unit 700 to the scheduling transfer position B, after a certain incubation time, the adjustment disc 620 rotates and drives the scheduling cup holding structure to move from the scheduling transfer position B to the scheduling transfer position C, the third transfer hand grip 930 transfers the reaction cup from the scheduling transfer position C to the photometric unit 800, and the photometric unit 800 measures the light intensity of the reaction solution in the reaction cup.

Cup throwing: the third transfer gripper 930 transfers the cuvette from the photometric unit 800 to a photometric cup-polishing station for cup-polishing.

Compared with the one-step test, in order to realize the automatic analysis of the two-step test, as shown in fig. 3, the method further comprises the following steps between the first cleaning separation and the light intensity measurement:

returning and transferring: the second transfer hand grip 920 transfers the reaction cup from the washing unit 700 to the reaction incubation transfer position B, the reaction incubation tray 610 rotates and drives the reaction incubation cup holding structure to move from the reaction incubation transfer position B to the reaction incubation transfer position a, and the first transfer hand grip 910 moves the reaction cup from the reaction incubation transfer position a to the sample adding operation position;

adding a reagent in the second step: the sample adding reaction disc 110 rotates to drive the sample adding holding cup structure to sequentially pass through the sample adding cup position and each row of liquid level and transfer to the sample adding operation position, wherein the reagent adding unit 510 sucks the reagent from the reagent supply unit 520 and adds the reagent to the reaction cup.

In this step, a sample is not added, but only a reagent is added.

And (3) incubation of reagents in two steps: the first transferring hand grip 910 transfers the reaction cup from the sample loading operation position to the reaction incubation transferring position a, and the reaction incubation tray 610 rotates and drives the reaction incubation cup holding structure to move from the reaction incubation transferring position a to the reaction incubation transferring position B.

Secondary cleaning and separation: the second transfer grip 920 transfers the cuvette from the reaction incubation transfer B site to the washing unit 700, and the washing unit 700 washes away the unbound and reacted sample and reagent in the cuvette.

If the pretreatment is needed, before the one-step reagent addition, the method further comprises the following steps:

pretreatment: the first transferring hand grip 910 transfers the reaction cup with the pretreatment solution from the reaction incubation transferring position a to the sample loading operation position, and the sample loading reaction tray 110 rotates again to drive the sample loading cup structure to move from the sample loading operation position to the sample loading cup position.

Here, the pretreatment solution in the cuvette can be obtained by referring to the flow of one-step reagent addition and one-step reagent incubation.

From the above, based on the structural design of the utility model, at first, through application of sample reaction dish 110, the dispatch of the rotation mode of reaction incubation dish 610 and adjustment dish 620, can enough simplify the structure of reaction cup transfer unit, the first tongs 910 that shifts of deuterogamying, the second shifts tongs 920 and the transferring of third transfer tongs 930, can carry out one-step process test or two-step test to the sample fast, improve autoanalyzer's test flux effectively, secondly, reaction incubation dish 610 and adjustment dish 620 can be with the environment of hatching of sharing one, be favorable to simplifying autoanalyzer's structure.

In one embodiment of the utility model, the position of the cup position on the sample adding position and the position of the sample adding operation position are arranged at intervals;

the sample-adding reaction disk 110 also drives the sample-adding holding cup structure to pass through a sample-adding dilution position when rotating, and the sample-adding dilution position is positioned between the sample-adding upper cup position and the sample-adding operation position;

the sample application unit 400 can also draw a sample from the application dilution site.

In this regard, if the automatic analyzer needs to perform a dilution operation, that is, if a reaction solution formed in one-step reagent addition is required as a sample to be tested, the following steps may be added between the one-step reagent addition and the one-step reagent incubation:

sample dilution addition: the sample adding and reacting disc 110 rotates to drive the sample adding and holding cup structure to move from the sample adding operation position to the sample adding and diluting position, and the sample adding unit 400 absorbs the sample from the sample adding and diluting position and adds the sample to the reaction cup;

transfer of diluted sample: the sample adding reaction tray 110 rotates to drive the sample adding holding cup structure to start from the liquid discharging position, pass through the liquid discharging position, and transfer to the sample adding operation position.

In another embodiment of the present invention, the sample-adding tray unit 100 further includes a dilution tray 120, the dilution tray 120 has a plurality of dilution cup-holding structures for holding reaction cups, each dilution cup-holding structure surrounds the rotation axis and is disposed at equal intervals, and the dilution tray 120 can drive the dilution cup-holding structures to sequentially pass through the dilution operation position and the dilution liquid-absorbing position when rotating;

the sample application unit 400 can also suck a sample from the dilution pipette;

the first transfer grip 910 transfers the cuvettes between the loading position, the diluting position, the reaction incubation transfer a position, and the scheduling transfer a position.

sample dilution addition: the sample adding and reacting disc 110 rotates to drive the sample adding and holding cup structure to move the sample adding operation position, the first transfer hand grip 910 transfers the reaction cup from the sample adding operation position to the diluting operation position, the diluting disc 120 rotates to drive the reaction cup to move from the diluting operation position to the diluting and sample sucking position, the sample adding unit 400 sucks the sample from the diluting and sample sucking position and adds the sample to the reaction cup;

transfer of diluted sample: the sample adding reaction tray 110 rotates to drive the sample adding holding cup structure to start from the liquid drainage position and transfer to the sample adding operation position.

Based on this dilution method, the sample application unit 400 can absorb the sample from the same cuvette in the dilution pipette position for a plurality of times without affecting the normal operation of the application reaction tray 110.

So, can realize once diluting the sample and test many times, the dilution efficiency of improvement reduces the use of consumptive material.

Furthermore, the rotation axes of the dilution disc and the sample-adding reaction disc are coaxially arranged and independently rotate, and the dilution disc is nested in the sample-adding reaction disc. So, at first, dilute dish and application of sample reaction dish mutually independent operation, each other does not influence, is favorable to adjusting respective rotation condition according to actual conditions, and secondly, dilute dish nestification in application of sample reaction dish, is favorable to reducing automatic analysis device's structural dimension.

In the embodiment of the present invention, the light measuring throwing cup position is located between the light measuring disc and the reaction scheduling unit, so that the third transferring gripper 930 can throw the cup on the movement track to and from the light measuring disc and the reaction scheduling unit, which is favorable for simplifying the structure and the movement stroke of the third transferring gripper 930.

Further, the light measuring cup throwing position is disposed between the reaction scheduling unit 600 and the light measuring unit 800, so that the original moving track of the third transfer gripper 930 can be reused, which is beneficial to simplifying the structure of the third transfer gripper 930.

The embodiment of the utility model provides an in, the second shifts tongs 920 can be hatched in the reaction and shift B position, dispatch and shift B position, cleaning unit 700 and wash and throw and shift the reaction cup between the cup position, and the washing is thrown and is lain in between cleaning unit 700 and the reaction scheduling unit 600 the cup position. Based on the structural design, a cleaning cup-throwing position is added, so that when the second transfer hand 920 grasps the reaction cup and the reaction cup does not need to participate in the subsequent cleaning, photometry and other processes, the reaction cup can be transferred to the cleaning cup-throwing position through the second transfer hand for cup throwing without transferring the reaction cup to the third transfer hand 930. In addition, the cleaning and cup throwing position is located between the cleaning unit 700 and the reaction scheduling unit 600, and the original moving track of the second transfer gripper 920 can be reused, so that the structure and the moving stroke of the second transfer gripper 920 are simplified.

In the embodiment of the present invention, the photometric unit 800 includes a photometric disk 810, a photometric instrument 820, a waste liquid absorbing mechanism (not labeled in the figure), and an exciting liquid injecting mechanism;

the light measuring disc 810 is of a disc type structure and is provided with a plurality of light measuring support cup structures which surround the rotation axis and are arranged at equal intervals; the light meter 820 is used for measuring light of the reaction cup; the waste liquid absorbing mechanism is arranged above the photometric disk 810 and is used for absorbing liquid into the reaction cup which finishes photometry; the excitation liquid injection mechanism is used for injecting excitation liquid capable of exciting to emit light into the reaction cup before the light intensity of the reaction cup is measured, and the excitation liquid is added before the light intensity is measured to excite the reaction liquid to emit certain light intensity, so that the light intensity can be conveniently measured by the light measuring instrument 820.

In the embodiment of the present invention, as shown in fig. 1, the automatic analysis device further includes a reaction cup supply unit 200 for placing a reaction cup on the sample loading in the direction of the sample loading holding cup structure. The embodiment of the utility model provides an in, for guaranteeing the continuous supply of reaction cup, preferably, reaction cup supply unit 200 is including the feed bin that is used for depositing the reaction cup for carry the feed mechanism of reaction cup and be used for the material loading slide with the reaction cup sequencing, the cup position is direct or indirectly continuous on material loading slide and the application of sample, the reaction cup can be followed the material loading slide and directly slided the cup position on the application of sample, still set up a reaction cup stop mechanism on the material loading slide, be used for controlling whether the reaction cup can slide the cup position on the application of sample.

In the embodiment of the present invention, in order to ensure the continuous supply and recovery of the samples, the sample supply unit 310 is provided with a sample placing area, a sample transmission area and a sample recovery area, and the sample transmission area is provided with at least one sample transmission channel; the sample supply unit 310 further includes at least one sample rack 311 for holding at least one cuvette, and a scheduling mechanism capable of moving the sample rack 311 from any sample input area to any sample transfer passage and moving the sample rack 311 from any sample transfer passage to the sample collection area. Further, the sample transfer area has three sample transport channels, and the sample loading unit 400 can suck the samples from at least two sample transport channels, so that the continuous supply of the samples can be better ensured. Further, the sample supply unit 310 is further provided with an emergency sample introduction area; the scheduling mechanism can preferentially move the sample rack 311 from the emergency sample deposit area to the sample transport area so that, in use, when a sample rack 311 is to be tested in the emergency sample deposit area, the sample in the emergency sample deposit area is preferentially tested.

In the embodiment of the present invention, the automatic analyzer further includes a quality control unit 320;

the sample application unit 400 can periodically suck the control solution from the control unit 320 and apply the control solution to the cuvette at a discharge level.

By measuring the quality control liquid and taking the measurement data of the quality control liquid as reference data, the analysis performance of the automatic analysis device can be monitored, so that the measurement precision and accuracy of the automatic analysis device are improved.

During quality control test, a sample needle of the sample adding unit moves above a sample sucking port of the quality control disc unit, vertically moves downwards to suck a certain amount of quality control liquid, vertically moves upwards, moves the sample needle above a row of liquid level of a sample adding reaction disc, vertically moves downwards to a specified position of a reaction container, discharges a certain amount of quality control liquid, vertically moves upwards, moves the sample needle to move a sample needle cleaning mechanism, and cleans the inner wall and the outer wall of the sample needle.

It should be noted here that the quality control panel unit may further have a low-temperature storage function (usually 2-8 degrees celsius) of the quality control product, and after the quality control test is performed each time, the quality control liquid does not need to be taken out and stored in a refrigerator, which is greatly convenient for the user to perform quality control. The embodiment of the utility model provides an in, can also realize automatic quality control, the function of timing quality control for automatic analysis device is more intelligent more convenient, and wherein, automatic quality control is that automatic analysis device can automatic triggering according to quality control test result or other triggering condition (for example the test number reaches a fixed number, and the instrument is through maintaining etc.) of last time be the quality control test. The timing quality control means that a user can set a starting time for quality control, such as a fixed certain time, or before a batch of tests and after a batch of tests, an instrument automatically triggers and starts a quality control test according to the set starting time.

Further, the quality control unit 320 includes at least one quality control disk, each quality control disk rotates around a rotation axis, and each quality control disk has a plurality of quality control sample cup structures surrounding the rotation axis and arranged at equal intervals.

Therefore, the quality control test can be carried out for a plurality of times by loading the quality control sample once, the instrument can automatically carry out quality control and carry out quality control regularly, the complicated process that the quality control sample needs to be loaded once and the quality control test information is input once every time the quality control sample is carried out once is omitted, and the convenience of instrument operation is greatly improved.

The utility model discloses in the specific embodiment, cleaning unit 700 can be including magnetic separation dish, notes liquid mechanism, imbibition mechanism, mixing structure and magnetism adsorption mechanism.

The embodiment of the utility model provides an in, the application of sample holds in the palm the cup structure and dilutes and hold in the palm the cup structure and be the through-hole that link up from top to bottom and supply the reaction cup to pass and restrict the reaction cup and drop.

In other embodiments of the present invention, the reaction incubation disc 610 and the adjustment disc 620 may be used as a replacement for each other, and after the reaction incubation disc 610 and the adjustment disc 620 are replaced for each other, the automatic analysis steps for realizing the one-step test are as follows:

one-step reagent addition: sample adding reaction disc 110 rotates, it is originated to drive sample adding support cup structure from the cup position on the sample adding, and pass through each row of liquid level in proper order, and transfer to sample adding operation position, wherein, reaction cup supply unit 200 cup position places the reaction cup to sample adding support cup structure on the sample adding, sample adding unit 400 absorbs the sample from sample supply unit 310, and add the sample to the reaction cup that is located a row of liquid level department, reagent adding unit 510 absorbs the reagent from reagent supply unit 520, and add the reagent to the reaction cup that is located a row of liquid level department.

One-step reagent incubation: the first transferring hand 910 transfers the reaction cup from the sample loading operation position to the reaction incubation transfer position a, the scheduling transfer position a, and after a certain incubation time, the adjusting disc 610 rotates and drives the scheduling cup holding structure to move from the reaction incubation transfer position a, the scheduling transfer position a to the reaction incubation transfer position B, the scheduling transfer position B.

Cleaning and separating: the second transfer grip 920 transfers the cuvette from the reaction incubation transfer position B to the washing unit 700, and the washing unit 700 washes away the sample and the reagent that are not combined and reacted in the cuvette.

Measuring light intensity: the second transfer hand grip 920 transfers the reaction cup from the cleaning unit 700 to the scheduling transfer position a for reaction incubation transfer position B, after a certain incubation time, the reaction incubation tray 620 rotates and drives the reaction incubation cup supporting structure to move from the scheduling transfer position a for reaction incubation transfer position B to the scheduling transfer position B for reaction incubation transfer position C, the third transfer hand grip 930 transfers the reaction cup from the scheduling transfer position B for reaction incubation transfer position C to the photometric unit 800, and the photometric unit 800 measures the light intensity of the reaction solution in the reaction cup.

Cup throwing: the third transfer gripper 930 transfers the cuvette from the photometric unit 800 to a photometric cuvette-throwing position, and throws the cuvette.

In the embodiment of the present invention, the sample adding disk unit 100 further includes a blending mechanism;

the sample adding reaction disc 110 can drive the sample adding holding cup structure to sequentially pass through the sample adding cup position, each liquid discharging position, the mixing position and the sample adding operation position when rotating;

the blending mechanism is used for shaking and blending the reaction cups positioned at the blending position.

Based on this, it can pass through the mixing position to drive the in-process that application of sample held in the palm the cup structure from a row of liquid level removal to application of sample operation position at application of sample reaction disc 110, rocks the mixing through mixing mechanism to the reaction cup, is favorable to making sample evenly distributed in the reagent.

Specifically, in the embodiment of the utility model, when mixing mechanism need carry out the mixing, mixing mechanism cooperates with the bottom of reaction cup, thereby rock the bottom of reaction cup, therefore, when mixing mechanism needs carry out the mixing, both can be application of sample reaction dish 110 downstream, reset after the mixing is accomplished, also can be mixing mechanism upward movement, reset after the mixing is accomplished, wherein, the technical scheme who adopts mixing mechanism upward movement is favorable to simplifying automatic analysis device's overall structure complexity, wherein, mixing mechanism adopts non-contact swirl eccentric oscillation mode, also can adopt supersound mixing mode, mixing mechanism has perpendicular up-and-down motion, when needing the mixing, mixing mechanism perpendicular up-and-down motion, fall into mixing mechanism with a part of reaction cup, begin the reaction liquid mixing, after a period of mixing, mixing mechanism perpendicular down-motion, get back to initial position.

The above description is only exemplary of the present invention and should not be construed as limiting the present invention, and any modification, equivalent replacement or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An automatic analysis device, comprising:

the sample adding and reacting disc unit comprises a sample adding and reacting disc, the sample adding and reacting disc rotates around a rotating axis, the sample adding and reacting disc is provided with a plurality of sample adding and supporting cup structures for supporting and reacting cups, each sample adding and supporting cup structure surrounds the rotating axis and is arranged at equal intervals, and the sample adding and reacting disc can drive the sample adding and supporting cup structures to sequentially pass through a sample adding cup position, at least one liquid discharging position and a sample adding operation position when rotating;

the sample adding unit can suck a sample from the sample supply unit and add the sample to a reaction cup positioned at the liquid discharging level;

the reaction incubation disc and the scheduling disc rotate around the same rotating axis respectively and independently, the reaction incubation disc is provided with a plurality of reaction incubation cup supporting structures for supporting reaction cups, each reaction incubation cup supporting structure surrounds the rotating axis and is arranged at equal intervals, the reaction incubation disc can drive the reaction incubation cup supporting structures to at least pass through a reaction incubation transfer A position, a reaction incubation transfer B position and a reaction incubation transfer C position when rotating, the scheduling disc is provided with a plurality of scheduling cup supporting structures for supporting the reaction cups, each scheduling cup supporting structure surrounds the rotating axis and is arranged at equal intervals, and the scheduling disc can drive the scheduling cup supporting structures to at least pass through a scheduling transfer A position, a scheduling transfer B position and a scheduling transfer C position when rotating;

the reaction cup transferring unit comprises a first transferring gripper, a second transferring gripper and a third transferring gripper, the first transferring gripper can transfer reaction cups among the sample adding operation position, the reaction incubation transferring A position and the scheduling transferring A position, the second transferring gripper can transfer reaction cups among the reaction incubation transferring B position, the scheduling transferring B position and the cleaning unit, and the third transferring gripper can transfer reaction cups among the reaction incubation transferring C position, the scheduling transferring C position, the photometric unit and the photometric polishing position.

2. The automatic analyzer as claimed in claim 1, wherein the position of the cup-on-sample position and the position of the sample application operation position are arranged at intervals;

the sample adding cup structure is driven to pass through a sample adding dilution position by the sample adding reaction disc when the sample adding reaction disc rotates, and the sample adding dilution position is positioned between the sample adding cup position and the sample adding operation position;

the sample loading unit can also suck a sample from the loading dilution position.

3. The automatic analyzer according to claim 1, wherein the sample loading tray unit further comprises a dilution tray having a plurality of dilution cup structures for holding reaction cups, each of the dilution cup structures surrounding the rotation axis and being disposed at equal intervals, the dilution tray being capable of driving the dilution cup structures to sequentially pass through a dilution operation position and a dilution suction position when rotated;

the sample adding unit can also absorb a sample from the dilution liquid absorption position;

the first transfer hand grip transfers the reaction cup among the sample adding operation position, the diluting operation position, the reaction incubation transfer A position and the scheduling transfer A position.

4. The automatic analyzer as claimed in claim 3, wherein the rotation axes of the dilution disk and the sample application and reaction disk are coaxially arranged and independently rotated, and the dilution disk is nested in the sample application and reaction disk.

5. The automatic analyzer according to claim 1, wherein there are provided two reagent supply units, the two reagent supply units operate independently of each other, and there are provided two reagent addition units, the two reagent supply units being provided in one-to-one correspondence with the two reagent addition units, respectively.

6. The automatic analyzer as claimed in claim 1, wherein the sample supply unit is provided with a sample introduction section, a sample transfer section and a sample recovery section, the sample transfer section being provided with at least one sample transfer passage;

the sample supply unit further comprises at least one sample rack for holding at least one reaction cup, and a scheduling mechanism capable of moving the sample rack from any one of the sample introduction sections to any one of the sample transport paths and moving the sample rack from any one of the sample transport paths to the sample collection section.

7. The automatic analysis device according to claim 6, wherein the sample transport section has three sample transport channels, and the sample application unit is capable of sucking up samples from at least the two sample transport channels;

and/or the sample supply unit is further provided with an emergency sample placing area, and the scheduling mechanism can preferentially move the sample rack from the emergency sample placing area to the sample transmission area.

8. The automated analyzer of claim 1, further comprising a cuvette supply unit for placing the cuvettes in the cuvette-in-sample position towards the cuvette-in-sample structure, the cuvette supply unit comprising a magazine for storing cuvettes, a loading mechanism for transporting cuvettes, and a loading chute for sequencing cuvettes;

the feeding slide way is directly or indirectly connected with the sample adding cup position, and the reaction cup can directly slide to the sample adding cup position from the feeding slide way; and the feeding slideway is also provided with a reaction cup blocking mechanism for controlling whether the reaction cup can slide to the cup position on the sample feeding.

9. The automated analysis apparatus of claim 1, wherein the dial is nested inside the reaction incubation dial.

10. The automated analyzer of claim 1, wherein the photometric polishing station is located between the photometric unit and the reaction scheduling unit.

11. The automatic analyzer as claimed in claim 1, wherein the photometric unit includes a photometric disk, a photometer, a waste liquid suction mechanism, and an excitation liquid injection mechanism;

the light measuring disc is of a disc type structure and is provided with a plurality of light measuring support cup structures for supporting the reaction cup, and each light measuring support cup structure surrounds the rotation axis and is arranged at equal intervals;

the photometer is used for measuring light of the reaction cup;

the waste liquid absorbing mechanism is arranged above the photometric disk and is used for absorbing liquid into the reaction cup which finishes photometry;

the exciting liquid injection mechanism is used for injecting exciting liquid capable of exciting luminescence into the reaction cup before the light intensity of the reaction cup is measured.

12. The automatic analyzer according to claim 1, further comprising a quality control unit; the sample adding unit can periodically absorb the quality control liquid from the quality control unit and add the quality control liquid to the reaction cup.

13. The automated analyzer of claim 12, wherein the quality control unit is of a disk type construction and comprises at least one quality control disk, each quality control disk being rotatable about an axis of rotation, the quality control disk having a plurality of quality control sample cups arranged at equal intervals around the axis of rotation.

14. The automatic analyzer of claim 1, wherein the sample application disk unit further comprises a mixing mechanism;

when the sample adding disc rotates, the sample adding cup supporting structure can be driven to sequentially pass through the sample adding operation position, each liquid discharging position and the mixing position;

the mixing mechanism is used for shaking and mixing the reaction cups positioned at the mixing position.