CN105259357A - Full-automatic chemiluminiscence tester - Google Patents
Full-automatic chemiluminiscence tester Download PDFInfo
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- CN105259357A CN105259357A CN201510759485.7A CN201510759485A CN105259357A CN 105259357 A CN105259357 A CN 105259357A CN 201510759485 A CN201510759485 A CN 201510759485A CN 105259357 A CN105259357 A CN 105259357A
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Abstract
The invention discloses a full-automatic chemiluminiscence tester which comprises a machine frame, a three-axis movement mechanism, a control unit and a reaction cup disc. A Z-axis movement mechanism of the three-axis movement mechanism is provided with a movable block capable of moving up and down. The movable block is fixedly connected with a multifunctional mechanical arm. The multifunctional mechanical arm comprises a pipe sleeve fixedly connected with the movable block. A sample adding pipe is arranged in an inner hole in the pipe sleeve in a sleeving mode. The lower end of the sample adding pipe stretches out of the pipe sleeve. The upper end of the sample adding pipe is connected with a sample adding pump through a hose. A probe of a pressure sensor is communicated with an inner hole of the hose. After the pressure sensor senses negative pressure existing in the inner hole of the hose, the sample adding pump is informed through a control unit for starting liquid suction. A sample container, a reagent container, a tip head arrangement unit, a function examination unit and a plate washing unit are arranged on the portion, below the Z-axis movement mechanism, of the machine frame. The function examination unit comprises a reaction cup disc moving mechanism, a warm bath box and a light metering mechanism. The pipe sleeve is provided with a grabbing assembly matched with the plate washing unit. The full-automatic chemiluminiscence tester is compact in structure, high in detection efficiency and low in detection cost.
Description
Technical field
The present invention relates to chemical luminescence detector, especially a kind of Full-automatic chemiluminescence analyzer.
Background technology
Full-automatic chemiluminescence analyzer combines having highly sensitive chemical luminescent detecting technology with the immune response of high specific, for the detection analytical technology of various antigen, haptens, antibody, hormone, enzyme, fatty acid, vitamin and medicine etc.It is the up-to-date immunoassay grown up after exempting from analysis, fluoroimmunoassay and time resolved fluoro-immunoassay continue radioimmunology analysis, enzyme.
Full-automatic chemiluminescence analyzer is also claiming Full-automatic chemiluminescence immunoassay analysis meter in the art, a patent No. of on 06 11st, 2014 bulletins is ZL201210556838.X, name is called the Chinese invention patent of " Full-automatic chemiluminescence immunoassay analysis meter ", it comprises sample introduction part, reaction controlling part and optical detecting parts, and sample introduction part comprises reaction cup warehouse, sample delivery device, reagent disc, Sample Dilution device, mechanical gripper, specimen needle, reagent needles, magnetic bead rabbling mechanism, dilution pin and dilution storehouse; Reaction controlling part is made up of reaction cup incubation dish, magnetic bead cleaning disc; Optical detecting parts is made up of optical detection dish, substrate pin and substrate storehouse; Above-mentioned all parts are installed in frame, and this sample introduction part and optical detecting parts lay respectively at the both sides of reaction controlling part; Described magnetic bead cleaning disc comprises reaction cup rotating disc, lifting punch block, magnetic bead adsorbent equipment and mixing friction pulley, lifting punch block drives linearly slide rail vertically to move up and down by spindle motor, lifting punch block is provided with four groups of cleaning needle assemblies, i.e. the first cleaning needle assembly, the second cleaning needle assembly, the 3rd cleaning needle assembly and the 4th cleaning needle assemblies; Described reaction cup rotating disc drives reaction cup to rotate; Cleaning needle assembly described in each comprises an injection needle for fluid injection and an aspirating needle for imbibition, first draws the waste liquid in reaction cup by aspirating needle, then in reaction cup, injects quantitative cleaning fluid by injection needle; Described mixing friction pulley is driven by stepper motor, be fixed on flexible electric machine support, mixing friction pulley has three groups, lays respectively at the position after the first cleaning needle assembly, the second cleaning needle assembly and the 3rd cleaning needle assembly, for mixing the reaction cup adding cleaning fluid; Described magnetic bead adsorbent equipment is provided with multiple magnet, magnetic suck is carried out to the magnetic bead in reaction cup, the magnetic bead in reaction cup is separated with solution; Stepper motor drives mixing friction pulley to drive reaction cup rotate and produce vibration to the friction force of reaction cup, ensures that the solution in reaction cup mixes; Described mixing friction pulley material is elastic caoutchouc.This Full-automatic chemiluminescence immunoassay analysis meter is in order to prevent the mutual pollution occurring chemical substance during application of sample, be provided with specimen needle, reagent needles, dilution pin and four groups of cleaning needle assemblies, cause total comparatively complicated and huge, be also unfavorable for overall control, have impact on detection efficiency.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Full-automatic chemiluminescence analyzer, its compact conformation, and detection efficiency is high, and testing cost is lower.
For achieving the above object, technical scheme of the present invention is: a kind of Full-automatic chemiluminescence analyzer, comprise frame, three-axis moving mechanism, control module and the reaction cup dish being provided with reaction cup, three-axis moving mechanism comprises the X-axis motion be erected in frame, the Z axis motion being erected at the Y-axis motion on X-axis motion and being erected on Y-axis motion, Z axis motion is equipped with movable block moving up and down, movable block is fixed with multifunctional mechanical arm, described multifunctional mechanical arm comprises the pipe box be connected mutually with movable block, application of sample pipe is arranged with in pipe box endoporus, application of sample pipe bottom is stretched out outside pipe box, the upper end of application of sample pipe connects sample-adding pump by flexible pipe, and flexible pipe endoporus is also communicated with the probe of a pressure transducer, starts imbibition after negative pressure appears in pressure sensor senses flexible pipe endoporus by control module notice sample-adding pump,
Frame below Z axis motion is provided with sample container, reagent container and tip head arrangement unit, functional check unit, washes Slab element;
Described functional check unit comprises reaction cup dish travel mechanism, warm bath cabinet and light-measuring mechanism, and described reaction cup dish travel mechanism is used for orienting response cup dish and reaction cup dish can be moved into warm bath cabinet carrying out heating or reaction cup dish being moved into light-measuring mechanism detecting;
Described wash Slab element comprise wash wrench, be connected wash wrench wash board mount, what board mount was washed in mounting washes plate pedestal;
Described pipe box is provided with grabbing assembly, and described grabbing assembly is for capturing and wash board mount from washing plate pedestal or be articulated in wash plate pedestal washing board mount; Described application of sample pipe bottom outside surface is provided with the structure matched with tip head endoporus top, and frame is provided with the counterpart that tip head is unloaded from application of sample pipe;
The each motion action of described control module cooperation control.
Further improvement, in the middle part of described application of sample pipe, cover has a spring, the upper end of spring withstands on pipe box, the lower end of spring is ordered about application of sample pipe and is moved down, pipe box endoporus is provided with the limiting section that restriction application of sample pipe shifts out pipe box downwards, and described pipe box endoporus is shoulder hole, and the shoulder of pipe box endoporus forms the limiting section that restriction application of sample pipe shifts out pipe box downwards, the upper end of pipe box endoporus is rotary with a collar, and spring upper end withstands on collar lower surface.Such application of sample pipe has certain buffer action, better to protect tip head when inserting and getting tip head.
Further again, described pipe box outside surface is provided with a strip groove distributed vertically, strip groove is communicated with pipe box endoporus, pipe box outside surface is provided with the first photo-coupler, a first optocoupler catch is through described strip groove, match with the first photo-coupler in first optocoupler catch one end, the other end is enclosed within application of sample pipe, the lower end of spring withstands on the first optocoupler catch and is enclosed within the other end of application of sample pipe, described application of sample pipe center outer surface is connected an annulus, and annulus upper end limits moving down of the first optocoupler catch.To be matched with the first photo-coupler by first optocoupler catch one end and better can judge whether application of sample pipe gets tip head.
Preferred described sample-adding pump comprises the first base plate, first base plate be equipped with the first motor and be provided with the first track, first track is combined with the first slide block, first motor driving shaft is connected a screw mandrel, first slide block is arranged a nut to match with screw mandrel, first base plate is also connected a cylinder sleeve, in cylinder sleeve bore, piston is housed, piston is connected a piston rod, one end of piston rod is stretched out outside cylinder sleeve and is connected with the first slide block, and cylinder sleeve connects described flexible pipe away from piston rod one end and makes cylinder sleeve bore can be communicated with described application of sample pipe orifice; Described first base plate is also connected second photo-coupler, and the first slide block is fixed with a second optocoupler catch and matches with the second photo-coupler.This structure sample-adding pump just conveniently can control liquid absorption by the formation of control piston bar.
Preferred described reaction cup dish travel mechanism comprises the second base plate, second base plate is provided with the second track along X-direction, second track extends in described temperature bath cabinet and light-measuring mechanism, second track is combined with reaction cup disc holder, second base plate is equipped with the second motor, the driving shaft of the second motor is vertically arranged and second driving wheel that is connected, and the second base plate is equipped with the second engaged wheel, second driving wheel is connected by the second belt with the second engaged wheel, and the second belt is connected reaction cup disc holder.
Preferred described temperature bath cabinet comprises casing, and a side of casing is provided with rotating chamber door, and the centre of box bottom is provided with a groove, and a fan is equipped with in the centre of groove, and the inside surface of described groove is provided with heating film; Heating film is provided with below roof box; Also be provided with cover plate below roof box, cover plate is connected on roof box by multiple bolt, and each bolt sleeve has the first stage clip, and the first stage clip withstands between cover plate and roof box.This temperature bath cabinet forces thermal cycle to the homogeneous heating being in solution in reaction cup in casing by fan and speed is fast, coordinates the volatilization that can also prevent solution in reaction cup by cover plate with reaction cup dish.
Preferred described grabbing assembly comprises a L shape and captures block and rear fixture block, one end that L shape captures block is enclosed within pipe box outside surface, rear fixture block is captured block made L shape capture block and rear fixture block to be clamped on pipe box by the bolt L shape that is connected, and the lower surface that L shape captures block is provided with two magnetic and coordinates posts;
Wash board mount preferably to comprise and wash plate buffing pad, wash plate magnetic receiver, wash plate buffing pad and wash wrench and be connected mutually, wash on plate buffing pad and two parallel guide pillars are set, washing plate magnetic receiver is enclosed within two parallel guide pillars, wash plate buffing pad and wash between plate magnetic receiver and the second stage clip is housed, described plate magnetic receiver of washing is provided with grafting pilot hole away from the one end washing plate buffing pad, and washing on plate magnetic receiver of described grafting pilot hole both sides arranges two magnet mounting holes, all magnet is housed in two magnet mounting holes; Described grafting pilot hole can match with the bottom of application of sample pipe, and the magnet in two magnet mounting holes coordinates post to match with two magnetic respectively;
The described side washing plate magnetic receiver is also provided with two mounting through holes; Described washing on plate pedestal is provided with two mounting bars, and two the mounting through holes washing plate magnetic receiver side are engaged on two mounting bars respectively.
Described wrench of washing is provided with liquid injection pipe, pipette, feed tube and drain pipe, feed tube is communicated with liquid injection pipe, drain pipe is communicated with pipette, described feed tube connects a solenoid valve by pipeline, solenoid valve connects in a washing lotion tank by pipeline again, and described drain pipe connects in a waste liquid tank by pipeline, and the air entry of an air pump is connected in waste liquid tank by pipeline, the gas outlet of air pump connects a reduction valve by pipeline, and reduction valve is connected in washing lotion tank by pipeline again.
Preferred described light-measuring mechanism comprises substrate, the first support and the second support, substrate being equipped with driving mechanism drives the first support to move back and forth along Y direction, second support is connected on the first support, the 3rd motor first support is equipped with, the driving shaft of the 3rd motor is along horizontal distribution and cam is housed, and the second support is provided with a contact block the second support when cam is rotated that matches with cam and moves up and down along Z-direction; Second support is provided with photon detector, and photon detector is provided with a sound-pipe, and the end of probe of sound-pipe is arranged down.
Preferred described sample container, reagent container and tip head arrangement unit comprise sample container containing rack, reagent container containing rack and tip head containing rack, sample container containing rack is contained in one along on the 3rd track of X-direction distribution, sample container containing rack can move around along the 3rd track, frame is provided with bar code scan unit, bar code scan unit scan head towards perpendicular with the 3rd track.To facilitate the sample tube to posting bar code to carry out scanning record, with better corresponding examining report.
Multifunctional mechanical arm of the present invention by connect disposable tip head, can carry out sample, various reagent, substrate application of sample and can not mutually pollute; The pipe box of simultaneously multifunctional mechanical arm is also provided with grabbing assembly, and multifunctional mechanical arm also can be captured by grabbing assembly and wash Slab element and clean the reaction cup on reaction cup dish; Multifunctional mechanical arm achieves the various motion in testing process, avoid needing to arrange the structures such as specimen needle, reagent needles, dilution pin and cleaning needle, decrease the mechanism that reaction cup dish carries out in each functional module transmitting, make the simple and compact for structure of Full-automatic chemiluminescence analyzer, reduce space hold, better realize the miniaturization of instrument.
On the other hand, during multifunctional mechanical arm drive tip head imbibition, needle end part once tip head touches liquid level, due to the effect of sample-adding pump and surface tension of liquid, negative pressure can be produced in the endoporus of flexible pipe endoporus and application of sample pipe, now pressure transducer can produce the pressure pulse of an instantaneous variation, judge to find liquid level, imbibition is started by control module notice sample-adding pump, sample-adding pump is just drawn onto required liquid in tip head endoporus by producing negative pressure, then sample-adding pump quits work, then can conveniently liquid in tip head endoporus be conveniently added in the reaction cup of analyzer.Without the need to the detection first utilizing draw point or carbon film Tip head to carry out liquid level, liquid level can be touched from tip head and complete continuously to the required liquid of absorption, simplify operation steps, save the running time, improve detection efficiency; Only need using common tip head in the detection in addition, without the need to adopting carbon film Tip head, adopting common tip head greatly to reduce than employing carbon film Tip head cost; By the raising of detection efficiency with lower-cost common tip head can be adopted to detect, just effectively testing cost can be reduced.
Accompanying drawing explanation
Fig. 1 is hidden parts upper cover stereographic map of the present invention;
Fig. 2 is each isolation of components state stereogram of the present invention;
Fig. 3 is multifunctional mechanical arm of the present invention, hide the Z axis motion after housing and sample-adding pump is interconnected stereographic map;
Fig. 4 is the vertical view that Fig. 3 hides sample-adding pump and flexible pipe;
Fig. 5 is the A-A cut-open view of Fig. 4;
Fig. 6 is the stereographic map of pipe box;
Fig. 7 is the stereographic map of tip head;
Fig. 8 is Function detection unit three-dimensional figure of the present invention;
Fig. 9 is the stereographic map that Fig. 8 hides lid and warm bath cabinet top plate member;
Figure 10 is that top plate member stereographic map hidden by warm bath cabinet;
Figure 11 is warm bath cabinet top plate member stereographic map;
Figure 12 is light-measuring mechanism front view;
Figure 13 is the left parallax stereogram of Figure 12;
Figure 14 is the right parallax stereogram of Figure 12;
Figure 15 washes Slab element stereographic map;
Figure 16 is that Figure 15 hides the three-dimensional exploded view washing plate pedestal;
Figure 17 washes plate tridimensional figure;
Figure 18 washes wrench principle of work structural drawing;
Figure 19 is that application of sample pipe racks of the present invention moves tip head imbibition Principle of Process schematic diagram.
Embodiment
Below in conjunction with accompanying drawing and concrete embodiment, the present invention is described in further detail.
Shown in Fig. 1 to Fig. 2, a kind of Full-automatic chemiluminescence analyzer, comprise frame 10, three-axis moving mechanism 20, control module 30 and be provided with the reaction cup dish 40 of reaction cup, turnover upper cover 101 is equipped with on the top of frame 10, and turnover side cover 102 is equipped with in the front side of frame 10; The Z axis motion 203 that three-axis moving mechanism 20 comprises the X-axis motion 201 be erected in frame 10, is erected at the Y-axis motion 202 on X-axis motion 201 and is erected on Y-axis motion 202, X-axis motion 201 and Y-axis motion 202 form planer type structure; 96 universal porose discs selected by reaction cup dish 40; Z axis motion 203 is equipped with movable block 1 moving up and down, movable block 1 is fixed with multifunctional mechanical arm 50.
Again shown in composition graphs 3 to Fig. 6, described Z axis motion 203 comprises a riser 2031, riser 2031 is connected the moving-member on Y-axis motion 202, Z axis motor 2032 riser 2031 is equipped with, the driving shaft of Z axis motor 2032 is arranged and the Z axis driving wheel 2033 that is connected in the horizontal direction, riser 2031 is provided with Z axis engaged wheel 2034, Z axis driving wheel 2033 is connected by Z axis belt 2035 with Z axis engaged wheel 2034, riser 2031 is provided with vertical track 2036, vertical track 2036 coordinates with described movable block 1, movable block 1 is connected Z axis belt 2035, movable block 1 is driven by Z axis belt 2035 and moves up and down.
Described multifunctional mechanical arm 50 comprises the pipe box 2 be connected mutually with movable block 1, is arranged with application of sample pipe 3 in pipe box 2 endoporus, and application of sample pipe 3 bottom is stretched out outside pipe box 2; The upper end of application of sample pipe 3 connects sample-adding pump 5 by flexible pipe 4, flexible pipe 4 endoporus is also communicated with the probe of a pressure transducer 6, notify that sample-adding pump 5 starts imbibition by control module 30 after negative pressure appears in pressure transducer 6 perception flexible pipe 4 endoporus, pressure transducer 6 is arranged on a circuit board 61, circuit board 61 is by wire connection control unit 30, and circuit board 61 becomes a part for control module 30;
In the middle part of described application of sample pipe 3, cover has a spring 31, the upper end of spring 31 withstands on pipe box 2, the lower end of spring 31 is ordered about application of sample pipe 3 and is moved down, pipe box 2 endoporus is provided with the limiting section that restriction application of sample pipe 3 shifts out pipe box 2 downwards, described pipe box 2 endoporus is shoulder hole, the shoulder 21 of pipe box 2 endoporus forms the limiting section that restriction application of sample pipe 3 shifts out pipe box 2 downwards, and the upper end of pipe box 2 endoporus is rotary with a collar 22, and spring 31 upper end withstands on the collar 22 lower surface.
Described pipe box 2 outside surface is provided with a strip groove 23 distributed vertically, strip groove 23 is communicated with pipe box 2 endoporus, pipe box 2 outside surface is provided with the first photo-coupler 1a, a first optocoupler catch 11a is through described strip groove 23, match with the first photo-coupler 1a in one end of first optocoupler catch 11a, the other end is enclosed within application of sample pipe 3, the lower end of spring 31 withstands on the first optocoupler catch 11a and is enclosed within the other end of application of sample pipe 3, described application of sample pipe 3 center outer surface is connected an annulus 32, and annulus 32 upper end limits moving down of the first optocoupler catch 11a.
Described sample-adding pump 5 comprises the first base plate 51, first base plate 51 be equipped with the first motor 52 and be provided with the first track 53, first track 53 is combined with the first slide block 54, first motor 52 driving shaft is connected a screw mandrel 55, first slide block 54 is arranged a nut 56 to match with screw mandrel 55, first base plate 51 is also connected a cylinder sleeve 57, in cylinder sleeve 57 endoporus, piston is housed, piston is connected a piston rod 58, one end of piston rod 58 is stretched out outside cylinder sleeve 57 and is connected with the first slide block 54, cylinder sleeve 57 connects described flexible pipe 4 away from piston rod 58 one end and makes cylinder sleeve 57 endoporus can be communicated with described application of sample pipe 3 endoporus, described first base plate 51 is also connected a second photo-coupler 2a, and the first slide block 54 is fixed with a second optocoupler catch 21a and matches with the second photo-coupler 2a.
Described riser 2031 is equipped with the 3rd photo-coupler 3a, the 3rd optocoupler catch 31a that movable block 1 is connected matches with the 3rd photo-coupler 3a.
Frame 10 below Z axis motion 203 is provided with sample container, reagent container and tip head arrangement unit 60, functional check unit 70, washes Slab element 80;
Described sample container, reagent container and tip head arrangement unit 60 comprise sample container containing rack 601, reagent container containing rack 602 and tip head containing rack 603, sample container containing rack 601 is contained in one along on the 3rd track 604 of X-direction distribution, sample container containing rack 601 can move around along the 3rd track 604, frame 10 is arranged bar code scan unit 90, bar code scan unit 90 scanner head towards perpendicular with the 3rd track 604; Like this when the multiple sample tube posting bar code are contained in sample container containing rack 601, multiple sample tube is along with sample container containing rack 601 is when the 3rd rail moving, bar code scan unit 90 is with regard to the bar code of each sample tube of energy fast recording, so that corresponding corresponding examining report, prevents from makeing mistakes after detecting;
The tip head that the present embodiment adopts as shown in Figure 7, it is a kind of general consumptive material, tip 100 tops are stepped cylindrical shape, tip 100 bottoms are coniform, the centre of tip 100 is provided with through hole, and be generally working of plastics, therefore tip head containing rack 603 arranges a flat board, flat board is arranged array type through hole, can an accommodating tip 100 on each through hole.
Again shown in composition graphs 8 to Figure 14, described functional check unit 70 comprises reaction cup dish travel mechanism 701, warm bath cabinet 702 and light-measuring mechanism 703, the reaction cup dish travel mechanism 701 of the present embodiment is arranged with two covers in parallel, therefore two reaction cup dishes 40 can be set simultaneously, further raising amount detection, improves detection efficiency; In order to corresponding two cover reaction cup dish travel mechanisms 701, warm bath cabinet 702 correspondence is provided with two.
Described reaction cup dish travel mechanism 701 is for orienting response cup dish 40 and reaction cup dish 40 can be moved into warm bath cabinet 702 and carry out heating or reaction cup dish 40 being moved into light-measuring mechanism 703 detecting, described reaction cup dish travel mechanism 701 comprises the second base plate 11b, the periphery of the second base plate 11b is provided with vertical coaming plate and forms a trough-shaped body, second base plate 11b is provided with the second track 12b along X-direction, second track 12b extends in described temperature bath cabinet 702 and light-measuring mechanism 703, second track 12b is combined with reaction cup disc holder 13b, second base plate 11b is equipped with the second motor, the driving shaft of the second motor is vertically arranged and the second driving wheel 14b that is connected, second driving wheel 14b is in light-measuring mechanism 703, the second engaged wheel 15b second base plate 11b is equipped with, second engaged wheel 15b is in warm bath cabinet 702, second driving wheel 14b is connected by the second belt 16b with the second engaged wheel 15b, second belt 16b is connected reaction cup disc holder 13b, reaction cup disc holder 13b drives displacement by the second belt 16b.
On described second base plate 11b, multiple 4th photo-coupler 17b is equipped with at interval, the side of reaction cup disc holder 13b is connected a L shape optocoupler baffle plate 18b, one end of one L shape optocoupler baffle plate 18b is along horizontally disposed, one L shape optocoupler baffle plate 18b is provided with the multiple first logical light groove 181b and coordinates with multiple 4th photo-coupler 17b, to judge reaction cup disc holder 13b and reaction cup dish 40 present position along horizontally disposed one end.
Also being provided with one above described reaction cup dish travel mechanism 701 can along the lid 19b of X-direction movement, lid 19b is provided with an auxiliary section 191b matched with the application of sample pipe 3 of multifunctional mechanical arm 50, application of sample pipe 3 matches with this auxiliary section 191b and lid 19b can be driven to move, to open lid 19b or to close lid 19b, improve automatization level further.
Described temperature bath cabinet 702 comprises casing 7021, casing 7021 is square shape, a side of casing 7021 is provided with rotating chamber door 21b, chamber door 21b corresponding reaction cup dish travel mechanism 701, move into facilitate reaction cup disc holder 13b and reaction cup dish 40, the centre of casing 7021 base plate is provided with a groove 22b, and a fan 23b is equipped with in the centre of groove 22b, and the inside surface of described groove 22b is provided with heating film 24b; Heating film 24b is provided with below roof box 25b;
Be provided with cover plate 26b below described roof box 25b, cover plate 26b is connected on roof box 25b by four bolt 27b, and each bolt 27b cover has the first stage clip 28b, and the first stage clip 28b withstands between cover plate 26b and roof box 25b; Described cover plate 26b is provided with upwards kink 261b near chamber door 21b side, is matched with reaction cup dish 40 by cover plate 26b, can prevent the volatilization of liquid in reaction cup.
At least one temperature sensor 29b is also provided with, to control heating-up temperature in described casing 7021.
Described light-measuring mechanism 703 comprises substrate 31b, first support 32b and the second support 33b, substrate 31b is connected on the vertical coaming plate that the second base plate 11b periphery is provided with in the horizontal direction, substrate 31b being equipped with driving mechanism 34b drives the first support 32b to move back and forth along Y direction, horizontal guide rail 311b is housed below substrate 31b, first support 32b is equipped with cross sliding clock 321b match with horizontal guide rail 311b, second support 33b is connected on the first support 32b, first support 32b is provided with vertical guide 322b, second support 33b is provided with vertical slide block 332b and matches with vertical guide 322b, the 3rd motor 35b first support 32b is equipped with, the driving shaft of the 3rd motor 35b is along horizontal distribution and cam 30b is housed, second support 33b is provided with a contact block 331b the second support 33b when cam 30b is rotated that matches with cam 30b to move up and down along Z-direction, second support 33b is provided with photon detector 36b, and photon detector 36b is provided with a sound-pipe 361b, and the end of probe of sound-pipe 361b is arranged down.
The end of probe cover of described sound-pipe 361b has a ladder cylinder-shaped sleeve 37b; The outside surface of described stepped cylindrical shape sleeve pipe 37b lower end is provided with taper chamfering 371b.
Described driving mechanism 34b comprises the 4th motor 341b, the driving shaft of the 4th motor 341b is vertically arranged, the driving shaft of the 4th motor 341b is connected the 4th driving wheel 342b, substrate 1 is arranged the 4th engaged wheel 343b, 4th driving wheel 342b is connected by the 4th belt 344b with the 4th engaged wheel 343b, 4th belt 344b is connected with the first support 32b phase, and the first support 32b drives displacement by the 4th belt 344b.
The 5th photo-coupler 5a is equipped with in described first support 32b side, the second support 33b is equipped with the 5th optocoupler catch 51a, the 5th optocoupler catch 51a matches with the 5th photo-coupler 5a.To differentiate height residing for the second support 33b and described sound-pipe 361b, be convenient to detection control.
The 6th photo-coupler 6a is equipped with in the upper surface of described first support 32b, substrate 1 is fixed the 2nd L shape optocoupler baffle plate 61a, one end of 2nd L shape baffle plate 61a vertically arranges and offers multiple the second logical light groove 611a vertically arranged, 2nd L shape baffle plate 61a vertically arranges one end and matches with the 6th photo-coupler 6a, to determine the horizontal level of the first support 32b and described sound-pipe 361b.
Again in conjunction with shown in Figure 15 to Figure 18, described in wash Slab element 80 comprise wash wrench 801, be connected wash wrench 801 wash board mount 802, what board mount 802 was washed in mounting washes plate pedestal 803;
Described pipe box 2 is provided with grabbing assembly 800, and described grabbing assembly 800 is for capturing and wash board mount 802 from washing plate pedestal 803 or be articulated in wash plate pedestal 803 washing board mount 802; Described application of sample pipe 3 bottom outside surface is provided with the structure matched with tip head endoporus top, frame 10 is provided with the counterpart 200 that tip head is unloaded from application of sample pipe 3, counterpart 200 is provided with a horizontal U-shaped draw-in groove and blocks tip 100 upper ends tip 100 is unloaded down from application of sample pipe 3, is also provided with waste material box 300 and accepts a tip after using 100 below counterpart 200.
Described grabbing assembly 800 comprises a L shape and captures block 80a and rear fixture block 80b, one end that L shape captures block 80a is enclosed within pipe box 2 outside surface, rear fixture block 80b is captured block 80a made L shape capture block 80a and rear fixture block 80b to be clamped on pipe box 2 by the bolt L shape that is connected, and the lower surface that L shape captures block 80a is provided with two magnetic and coordinates post 801a; Also stretch out two radial spacer pin 80c, each radial spacer pin 80c of described pipe box 2 outside surface is in L shape and captures between block 80a and rear fixture block 80b, better to prevent the rotation of grabbing assembly 800;
Described board mount 802 of washing comprises and washes plate buffing pad 8021, washes plate magnetic receiver 8022, wash plate buffing pad 8021 and wash wrench 801 and be connected mutually, preferably be provided with a downward opening U-lag in the bottom washing plate buffing pad 8021, the top washing wrench 801 is connected on U-lag, then locks that multiple trip bolt is fastening washes wrench 801 washing plate buffing pad 8021;
Wash on plate buffing pad 8021 and two parallel guide pillars 8023 are set, two guide pillars 8023 are connected in by two binding bolts 8024 both sides washing plate buffing pad 8021 upper surface, washing plate magnetic receiver 8022 is enclosed within two parallel guide pillars 8023, wash plate buffing pad 8021 and wash between plate magnetic receiver 8022 and second stage clip 8025 is housed, described plate magnetic receiver 8022 of washing is provided with grafting pilot hole 8026 away from the one end washing plate buffing pad 8021, washing on plate magnetic receiver 8022 of described grafting pilot hole 8026 both sides arranges two magnet mounting holes 8027, in two magnet mounting holes 8027, magnet 8028 is all housed, described grafting pilot hole 8026 can match with the bottom of application of sample pipe 3, and the magnet 8028 in two magnet mounting holes 8027 coordinates post 801a to match with two magnetic respectively,
The described side washing plate magnetic receiver 8022 is also provided with two mounting through holes 8029; Described washing on plate pedestal 803 is provided with two mounting bars 8031, and two the mounting through holes 8029 washing plate magnetic receiver 8022 side are engaged on two mounting bars 8031 respectively; The end mounting bar 8031 described in every root is provided with the spacing preiection 803a upwards extended, and deviates to mount bar 8031 to prevent washing plate magnetic receiver 8022.
Described washing plate pedestal 803 is equipped with microswitch 8032 and is washed plate magnetic receiver 8022 and match, and washes plate magnetic receiver 8022 and is articulated in when washing on plate pedestal 803 and touches microswitch 8032 contact.Can differentiate whether the mounting of washing plate magnetic receiver 8022 puts in place by microswitch 8032 action.
Described wrench 801 of washing is provided with liquid injection pipe 8011, pipette 8012, feed tube 8013 and drain pipe 8014, feed tube 8013 is communicated with liquid injection pipe 8011, drain pipe 8014 is communicated with pipette 8012, described washing below plate pedestal 803 is provided with a tank 8033, and tank 8033 accepts described liquid injection pipe 8011 and pipette 8012 dropping liquid; Described feed tube 8013 connects a solenoid valve 400 by pipeline, solenoid valve 400 connects in a washing lotion tank 500 by pipeline again, described drain pipe 8014 connects in a waste liquid tank 600 by pipeline, the air entry of one air pump 700 is connected in waste liquid tank 600 by pipeline, the gas outlet of air pump 700 connects a reduction valve 800 by pipeline, and reduction valve 800 is connected in washing lotion tank 500 by pipeline again.
The each motion action of described control module 30 cooperation control.
All motors of the present embodiment are all preferably stepper motor or servomotor.
Shown in Figure 18, the plate process of washing of the present embodiment is: three-axis moving mechanism 20 drives multifunctional mechanical arm 50 to move, be contained in grabbing assembly 800 on multifunctional mechanical arm 50 pipe box 2 just to capture to wash board mount 802 and be connected in wash from washing plate pedestal 803 board mount 802 washes wrench 801, moved to above reaction cup dish 40 wash wrench 801, will to when on reaction cup dish 40, reaction cup be cleaned, booster air pump 700, liquid injection pipe 8011 is first made to aim at reaction cup, then solenoid valve 400 is opened, squeezing into positive pressure air due to air pump 700 enters in washing lotion tank 500, pressure just makes the washing lotion water of washing lotion tank 500 enter and wash wrench 801 from washing feed tube 8013 wrench 801 and inject reaction cup from liquid injection pipe 8011, after injecting aequum, shut electromagnetic valve 400,
And then wrench 801 is washed in movement, utilizing washes in the pipette 8012 intercalation reaction cup of wrench 801, due to the effect of air pump 700, negative pressure is produced in waste liquid tank 600, the pipette 8012 and drain pipe 8014 of liquid in reaction cup just through washing wrench 801 reclaim and enter in waste liquid tank 600, so just complete and once wash plate action.
Again in conjunction with shown in Figure 19, the application of sample process of the present embodiment is: first imbibition, three-axis moving mechanism 20 drives multifunctional mechanical arm 50 to move, application of sample pipe 3 on multifunctional mechanical arm 50 is first from tip head containing rack 603 grafting tip 100, then after three-axis moving mechanism 20 moves to reach imbibition position the application of sample pipe 3 with tip 100, Z axis motion 203 drives application of sample pipe 1 and tip 100 to move down, sample-adding pump 5 starts simultaneously, first motor 52 drives screw mandrel 55 to rotate, nut 56 matches with screw mandrel 55 and first slide block 54 is moved, first slide block 54 drives piston rod 58 and piston to move beginning air-breathing, when tip 100 points touch liquid level, due to surface tension of liquid effect, negative pressure can be produced in application of sample pipe 3 endoporus and flexible pipe 4 endoporus, now pressure transducer 6 can produce the pressure pulse of an instantaneous variation, judge to find liquid level, notify that sample-adding pump 5 starts imbibition by control panel unit 30, the liquid absorption needed for now just being controlled by the stroke of control piston bar 58 and piston, after imbibition reaches desired volume, sample-adding pump 5 quits work, then Z axis motion 203 makes application of sample pipe 1 and inhales to have on the tip of liquid 100 to move, and liquid is attracted in the endoporus of tip 100.When the liquid drawn will be added reaction cup, three-axis moving mechanism 20 drives multifunctional mechanical arm 50 to move to above reaction cup dish 40, then reverse starting sample-adding pump 5 just can join the liquid drawn in reaction cup.So just complete an application of sample process.
After completing an application of sample process, three-axis moving mechanism 20 drives multifunctional mechanical arm 50 to move on counterpart 200, block tip 100 upper ends by U-shaped draw-in groove on counterpart 200 tip 100 is unloaded down from application of sample pipe 3, the tip that unloads down 100 falls in waste material box 300.Multifunctional mechanical arm 50 can carry out application of sample next time.
Multifunctional mechanical arm 50 of the present invention flexible movements, can need to arrange various course of action according to detection, with the needs of satisfied different test item.
Below be only the present invention's preferred embodiment, those skilled in the art makes by claim the protection domain that equivalent change all falls into this case.
Claims (10)
1. a Full-automatic chemiluminescence analyzer, comprise frame, three-axis moving mechanism, control module and be provided with the reaction cup dish of reaction cup, the Z axis motion that three-axis moving mechanism comprises the X-axis motion be erected in frame, is erected at the Y-axis motion on X-axis motion and is erected on Y-axis motion, is characterized in that:
Z axis motion is equipped with movable block moving up and down, and movable block is fixed with multifunctional mechanical arm, and described multifunctional mechanical arm comprises the pipe box be connected mutually with movable block, is arranged with application of sample pipe in pipe box endoporus, and application of sample pipe bottom is stretched out outside pipe box; The upper end of application of sample pipe connects sample-adding pump by flexible pipe, and flexible pipe endoporus is also communicated with the probe of a pressure transducer, starts imbibition after negative pressure appears in pressure sensor senses flexible pipe endoporus by control module notice sample-adding pump;
Frame below Z axis motion is provided with sample container, reagent container and tip head arrangement unit, functional check unit, washes Slab element;
Described functional check unit comprises reaction cup dish travel mechanism, warm bath cabinet and light-measuring mechanism, and described reaction cup dish travel mechanism is used for orienting response cup dish and reaction cup dish can be moved into warm bath cabinet carrying out heating or reaction cup dish being moved into light-measuring mechanism detecting;
Described wash Slab element comprise wash wrench, be connected wash wrench wash board mount, what board mount was washed in mounting washes plate pedestal;
Described pipe box is provided with grabbing assembly, and described grabbing assembly is for capturing and wash board mount from washing plate pedestal or be articulated in wash plate pedestal washing board mount; Described application of sample pipe bottom outside surface is provided with the structure matched with tip head endoporus top, and frame is provided with the counterpart that tip head is unloaded from application of sample pipe;
The each motion action of described control module cooperation control.
2. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: in the middle part of described application of sample pipe, cover has a spring, the upper end of spring withstands on pipe box, the lower end of spring is ordered about application of sample pipe and is moved down, pipe box endoporus is provided with the limiting section that restriction application of sample pipe shifts out pipe box downwards, and described pipe box endoporus is shoulder hole, and the shoulder of pipe box endoporus forms the limiting section that restriction application of sample pipe shifts out pipe box downwards, the upper end of pipe box endoporus is rotary with a collar, and spring upper end withstands on collar lower surface.
3. a kind of Full-automatic chemiluminescence analyzer according to claim 2, it is characterized in that: described pipe box outside surface is provided with a strip groove distributed vertically, strip groove is communicated with pipe box endoporus, pipe box outside surface is provided with the first photo-coupler, a first optocoupler catch is through described strip groove, match with the first photo-coupler in first optocoupler catch one end, the other end is enclosed within application of sample pipe, the lower end of spring withstands on the first optocoupler catch and is enclosed within the other end of application of sample pipe, described application of sample pipe center outer surface is connected an annulus, annulus upper end limits moving down of the first optocoupler catch.
4. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described sample-adding pump comprises the first base plate, first base plate be equipped with the first motor and be provided with the first track, first track is combined with the first slide block, first motor driving shaft is connected a screw mandrel, first slide block is arranged a nut to match with screw mandrel, first base plate is also connected a cylinder sleeve, in cylinder sleeve bore, piston is housed, piston is connected a piston rod, one end of piston rod is stretched out outside cylinder sleeve and is connected with the first slide block, cylinder sleeve connects described flexible pipe away from piston rod one end and makes cylinder sleeve bore can be communicated with described application of sample pipe orifice, described first base plate is also connected second photo-coupler, and the first slide block is fixed with a second optocoupler catch and matches with the second photo-coupler.
5. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described reaction cup dish travel mechanism comprises the second base plate, second base plate is provided with the second track along X-direction, second track extends in described temperature bath cabinet and light-measuring mechanism, second track is combined with reaction cup disc holder, the second motor second base plate is equipped with, the driving shaft of the second motor is vertically arranged and second driving wheel that is connected, the second engaged wheel second base plate is equipped with, second driving wheel is connected by the second belt with the second engaged wheel, second belt is connected reaction cup disc holder.
6. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described temperature bath cabinet comprises casing, a side of casing is provided with rotating chamber door, the centre of box bottom is provided with a groove, a fan is equipped with in the centre of groove, and the inside surface of described groove is provided with heating film; Heating film is provided with below roof box; Also be provided with cover plate below roof box, cover plate is connected on roof box by multiple bolt, and each bolt sleeve has the first stage clip, and the first stage clip withstands between cover plate and roof box.
7. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described grabbing assembly comprises a L shape and captures block and rear fixture block, one end that L shape captures block is enclosed within pipe box outside surface, rear fixture block is captured block made L shape capture block and rear fixture block to be clamped on pipe box by the bolt L shape that is connected, and the lower surface that L shape captures block is provided with two magnetic and coordinates posts;
Described board mount of washing comprises and washes plate buffing pad, washes plate magnetic receiver, wash plate buffing pad and wash wrench and be connected mutually, wash on plate buffing pad and two parallel guide pillars are set, washing plate magnetic receiver is enclosed within two parallel guide pillars, wash plate buffing pad and wash between plate magnetic receiver and the second stage clip is housed, described plate magnetic receiver of washing is provided with grafting pilot hole away from the one end washing plate buffing pad, and washing on plate magnetic receiver of described grafting pilot hole both sides arranges two magnet mounting holes, all magnet is housed in two magnet mounting holes; Described grafting pilot hole can match with the bottom of application of sample pipe, and the magnet in two magnet mounting holes coordinates post to match with two magnetic respectively;
The described side washing plate magnetic receiver is also provided with two mounting through holes; Described washing on plate pedestal is provided with two mounting bars, and two the mounting through holes washing plate magnetic receiver side are engaged on two mounting bars respectively.
8. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described in wash wrench and be provided with liquid injection pipe, pipette, feed tube and drain pipe, feed tube is communicated with liquid injection pipe, drain pipe is communicated with pipette, described feed tube connects a solenoid valve by pipeline, solenoid valve connects in a washing lotion tank by pipeline again, described drain pipe connects in a waste liquid tank by pipeline, the air entry of one air pump is connected in waste liquid tank by pipeline, the gas outlet of air pump connects a reduction valve by pipeline, and reduction valve is connected in washing lotion tank by pipeline again.
9. a kind of Full-automatic chemiluminescence analyzer according to claim 1, it is characterized in that: described light-measuring mechanism comprises substrate, the first support and the second support, substrate being equipped with driving mechanism drives the first support to move back and forth along Y direction, second support is connected on the first support, the 3rd motor first support is equipped with, the driving shaft of the 3rd motor is along horizontal distribution and cam is housed, and the second support is provided with a contact block the second support when cam is rotated that matches with cam and moves up and down along Z-direction; Second support is provided with photon detector, and photon detector is provided with a sound-pipe, and the end of probe of sound-pipe is arranged down.
10. a kind of Full-automatic chemiluminescence analyzer according to any one of claim 1 to 9, it is characterized in that: described sample container, reagent container and tip head arrangement unit comprise sample container containing rack, reagent container containing rack and tip head containing rack, sample container containing rack is contained in one along on the 3rd track of X-direction distribution, sample container containing rack can move around along the 3rd track, frame is provided with bar code scan unit, bar code scan unit scan head towards perpendicular with the 3rd track.
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| CN201510759485.7A CN105259357A (en) | 2015-11-09 | 2015-11-09 | Full-automatic chemiluminiscence tester |
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| CN201510759485.7A CN105259357A (en) | 2015-11-09 | 2015-11-09 | Full-automatic chemiluminiscence tester |
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| CN108519332B (en) * | 2018-04-28 | 2019-12-03 | 南通市肺科医院（南通市第六人民医院） | Full-automatic microwell plate system and the computer-readable medium for the system |
| CN108519332A (en) * | 2018-04-28 | 2018-09-11 | 南通市肺科医院（南通市第六人民医院） | Full-automatic microwell plate system and the computer-readable medium for the system |
| CN110883039A (en) * | 2018-09-11 | 2020-03-17 | 深圳市新产业生物医学工程股份有限公司 | Adsorption mechanism, cleaning device, chemiluminescence detector and cleaning method |
| US11143652B2 (en) | 2018-09-11 | 2021-10-12 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Adsorption mechanism, cleaning device, chemiluminescence detector and cleaning method |
| US11513116B2 (en) | 2018-09-11 | 2022-11-29 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Cleaning device and chemiluminescence detector |
| CN111458530A (en) * | 2020-05-12 | 2020-07-28 | 四川新健康成生物股份有限公司 | Dry-type immunoassay appearance application of sample device |
| CN113514657A (en) * | 2021-04-22 | 2021-10-19 | 长沙海柯生物科技有限公司 | Multifunctional sample adding device for inspection equipment |
| CN113275342A (en) * | 2021-06-22 | 2021-08-20 | 宙斯生命科技(常州)有限公司 | Reaction cup washing mechanism and reaction cup washing method |
| CN113275342B (en) * | 2021-06-22 | 2023-11-14 | 宙斯生命科技(常州)有限公司 | Reaction cup washing mechanism and reaction cup washing method |
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