CN109324200B - Sample analyzer - Google Patents

Abstract

The invention belongs to the technical field of sample analysis, and provides a sample analyzer, which is characterized in that a host and a sample injector separated from the host are arranged, the sample injector performs at least one sampling operation on a sample and then sends the sample to a sampling station, the sampling station is cascaded with the host to sample the sample, the host comprises a sampling arm, an incubation disc measuring device and a reagent supplying device which are arranged in a row, the sampling arm absorbs a reagent and the sample from the reagent supplying device and the sampling station and injects the reagent and the sample into a reaction cup arranged in the incubation disc measuring device to perform incubation test, thereby realizing high-efficiency sample feeding, integrating the separable pre-sampling operation subgroup originally integrated in the sample analyzer into the sample injector, the automatic cascade host computer is realized to carry out sampling detection on the sample, the detection efficiency is improved, the volume and the weight of the sample analyzer are reduced, and the purposes that the sample injector and the host computer can be produced in a modularized mode and are matched with each other in a flow line type cascade mode are achieved.

Description

Sample analyzer

Technical Field

The invention belongs to the technical field of sample analysis, and particularly relates to a sample analyzer.

Background

Currently, in clinical examination of sample data, a sample analyzer is often used, which includes a sample injector and a main unit, which are installed in one apparatus housing as two functional mechanisms of the sample analyzer. The sample injector conveys the vacuum tube with the sample to a sampling station of the host machine, and the host machine extracts the sample in the vacuum tube to carry out a series of inspection processing so as to obtain sample data.

Disclosure of Invention

Research shows that the existing sample injector mostly adopts a single direction, the sample is fed and advanced by the hook claw, the sample cannot run in the opposite direction, and the running speed of the hook claw is low, so that the detection speed of the whole detection system is limited by the sample injection speed. In addition, since a plurality of project tests are usually performed on the same sample, after one project test is performed on the same sample in one instrument, the sample needs to be manually placed in another instrument to test other projects, which is time-consuming and labor-consuming. In addition, the existing sample injector only has a single sample injection function, and a series of operation subgroups before sampling related to sample inspection are integrated into the sample analyzer, so that the sample analyzer is bulky and inconvenient to use, and the mechanism is unreasonable in arrangement, thereby causing resource waste.

In summary, the existing sample analyzer has the defects of large volume, low efficiency and incapability of cascading expansion and use, and therefore, the defect needs to be improved.

The present invention provides a sample analyzer comprising: a host and an injector separate from the host; the sample injector is used for carrying out at least one sampling operation on the sample and then sending the sample to a sampling station; the sampling station is cascaded with the host to sample the sample;

the host comprises a sampling arm, an incubation disc measuring device and a reagent supply device which are arranged in a row; the sampling arm takes the reagent from the reagent supply device and the sampling station and puts the sample into the incubation tray measuring device for incubation testing.

Specifically, the sample injector comprises a bottom plate, a reciprocating sample feeding sub group and at least one pre-sampling operation sub group, wherein the reciprocating sample feeding sub group and the at least one pre-sampling operation sub group are arranged on the bottom plate; a sample region to be detected is arranged on the bottom plate;

the reciprocating sample feeding subgroup is positioned at one side of the sample region to be measured and is used for conveying a sample rack loaded with a sample tube into the sample region to be measured in a reciprocating manner; the at least one sub-group of pre-sampling operations is located on one side of the reciprocating sample feeding sub-group to perform a pre-sampling operation on a sample.

Specifically, the pre-sampling operational subgroup comprises a loading subgroup; the loading subgroup is used for pushing the sample rack into the inlet of the reciprocating sample feeding subgroup.

In particular, the pre-sampling operational subset comprises a rotational scanning subset; the rotational scanning subgroup is used for reading the identification information on the sample tube.

Specifically, the pre-sampling operational subgroup comprises a shake-up subgroup; the shaking group grabs the sample tube and shakes the sample for the host computer to puncture the sample tube for sampling.

Specifically, the pre-sampling operation subgroup comprises a push pipe subgroup; the push pipe group moves forwards to prop against the sample pipe so as to be used for puncture sampling of the host.

Specifically, a sample recovery area is further arranged on one side of the reciprocating sample feeding subgroup on the bottom plate and used for recovering the sample rack after the examination is finished; the pre-sampling operational subset comprises an unload subset; the unloading subgroup is used for pushing the sample rack after the test is completed into the sample recovery area.

Specifically, the pre-sampling operation subgroup comprises an emergency sample introduction subgroup; the emergency sample introduction sub-group is used for inserting a sample tube needing emergency detection into the sample region to be detected.

Specifically, the sampling arm comprises a translation module, a puncture arm and a reagent arm, wherein the puncture arm and the reagent arm are respectively connected with the translation module in a horizontal transmission manner and can vertically move for sample adding; the puncture arm comprises a sample needle and a stirring and cleaning mechanism;

the stirring and cleaning mechanism is arranged at the bottom end of the puncture arm, and the sample needle is arranged on one side of the puncture arm; the stirring and cleaning mechanism can drive the sample needle to stir a sample, and can spray cleaning liquid to clean the sample needle.

Specifically, the incubation tray measuring device includes: the device comprises an integrated plate, and a rotating assembly, an incubation assembly, a measurement module and a multi-stage cleaning assembly which are arranged on the integrated plate; the rotating assembly drives the incubation assembly to rotate below the incubation assembly;

the measurement module is used for measuring the sample value of liquid in a reaction cup incubated in the incubation assembly on one side of the incubation assembly; and the multistage cleaning assembly sucks the liquid in the reaction cup through the operation port of the incubation assembly, and then the operations of injecting cleaning liquid and sucking the liquid are carried out for multiple times to clean the reaction cup.

Specifically, the reagent supplying apparatus includes: the heating box and the refrigerating box are respectively in transmission connection with the belt conveying mechanism;

reagent bottles filled with different types of reagents are respectively placed in the heating box and the refrigerating box at constant temperature, and the belt conveying mechanism drives an elastic reset door arranged on a case of the main machine to be pushed open to move to a reagent bottle replacing station outside the case.

The sample analyzer provided by the invention is provided with a host and a sample injector separated from the host, wherein the sample injector performs at least one sampling operation on a sample and then sends the sample to a sampling station, the sampling station cascades the host to sample the sample, the host comprises a sampling arm, an incubation disc measuring device and a reagent supply device which are arranged in a row, the sampling arm absorbs a reagent and the sample from the reagent supply device and the sampling station and injects the reagent and the sample into a reaction cup arranged in the incubation disc measuring device to perform incubation test, so that high-efficiency sample sending is realized, separable sampling operation subgroups originally integrated in the sample analyzer are integrated into the sample injector, the sample is automatically detected by the cascade host, the inspection efficiency is improved, the volume and the weight of the sample analyzer are reduced, and the purposes of modular production and pipeline type cascade matching of the sample injector and the host are achieved.

Drawings

FIG. 1 is a schematic diagram of a sample analyzer according to an embodiment;

FIG. 2 is a schematic structural diagram of a sample injector according to an embodiment;

FIG. 3 is a schematic diagram of a partial structure of the sample injector in FIG. 2;

FIG. 4 is a schematic structural diagram of a rotational scanning subgroup according to an embodiment;

FIG. 5 is a schematic structural diagram of a tube drawing mechanism according to an embodiment;

FIG. 6 is a schematic structural diagram of a buffering mechanism according to an embodiment;

FIG. 7 is a schematic diagram of a reciprocating sample feeding sub-group according to an embodiment;

FIG. 8 is a partial schematic view of the reciprocating sample feeding sub group;

fig. 9 is a schematic structural diagram of an emergency sample feeding sub-group according to an embodiment;

FIG. 10 is a schematic structural diagram of a shake-up sub-group according to an embodiment;

FIG. 11 is a schematic structural diagram of a set of push pipes according to an embodiment;

FIG. 12 is a schematic diagram of a sampling arm according to an embodiment;

FIG. 13 is a schematic structural diagram of an incubation tray measuring device provided in an embodiment

FIG. 14 is a schematic diagram of a multi-stage cleaning assembly according to an exemplary embodiment;

FIG. 15 is a schematic view of the structure of the cleaning pin set in FIG. 14;

FIG. 16 is a schematic structural diagram of a reagent supplying apparatus according to an embodiment;

FIG. 17 is a diagram illustrating an embodiment of a sampling arm and a reagent supply apparatus for sampling;

FIG. 18 is a diagram showing the reagent supplying apparatus after pushing open the elastic return door of the main body.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.

Furthermore, in the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two elements may be directly connected or indirectly connected through an intermediate medium, or may be communicated with each other inside the two elements, or may be wirelessly connected or wired connected. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Furthermore, the technical features mentioned in the different embodiments of the invention described later can be combined with each other as long as they do not conflict with each other.

In the following, the present invention proposes some preferred embodiments to teach those skilled in the art to implement.

Fig. 1 is a schematic structural diagram of a sample analyzer according to an embodiment, which illustrates a sample analyzer that is compact, efficient, and scalable for cascade use. The sample analyzer may be used to analyze a specific protein sample.

Referring to fig. 1, a sample analyzer includes: the sample injector comprises a host A and a sample injector B separated from the host A; the sample injector B performs at least one sampling operation on the sample and then sends the sample to a sampling station; the sampling station cascade host A samples a sample;

the host machine A comprises a sampling arm X, an incubation disc measuring device J and a reagent supply device S which are arranged in a row; the sampling arm X takes the reagent from the reagent supply device S and the sampling station and puts the sample into the incubation tray measuring device J for incubation test.

In the embodiment, a host A and a sample injector B separated from the host A are arranged, the sample injector B performs at least one sampling operation on a sample and then sends the sample to a sampling station, the sampling station is cascaded with the host A to sample the sample, the host A comprises a sampling arm X, an incubation disc measuring device J and a reagent supply device S which are arranged in a row, the sampling arm X absorbs a reagent and the sample from the reagent supply device S and the sampling station and injects the reagent and the sample into a reaction cup arranged in the incubation disc measuring device J to perform incubation test, thereby realizing high-efficiency sample feeding, integrating the separable pre-sampling operation subgroup originally integrated in the sample analyzer into the sample injector B, the automatic cascade host A is used for sampling and detecting samples, the inspection efficiency is improved, the volume and the weight of the sample analyzer are reduced, and the purposes that the sample injector B and the host A can be produced in a modularized mode and are matched with each other in a flow line type cascade mode are achieved.

The pre-sampling operation refers to an operation performed by the host a before sampling the sample tube in the sample rack, for example, an operation such as sample tube label recognition or sample tube sample shaking. In the prior art, the operation before sampling is only a sample feeding operation, and actuating mechanisms for executing the sample feeding operation, the sample tube label identification, the sample tube sample shaking and the like are all arranged in the host computer A, so that the host computer A is large in size and heavy in weight. In addition, the sample injector B separate from the host a means that the sample injector B can be manufactured and sold separately. The existing host A is integrated with a sample injection mechanism, and the sample injection mechanism is manufactured, produced and sold as a part of the host A.

In this embodiment, the execution mechanism for executing the sample feeding and the pre-sampling operation subgroup for executing the sampling operation are independently designed into a high-speed reciprocating cascadable auto-sampler B, so that a completely new sample-sampler B is invented, all the hosts a can use the sample-sampler B to perform the sample feeding and pre-sampling operations, and the technical effects of modular production and pipeline type cascade coordination of the hosts a and the sample-sampler B can be achieved.

In addition, after the executing mechanism for the operation before sampling of the host A for detecting different sample items is stripped from the host A to form a brand-new sample injector B, the sample injector B can be in cascade connection with different hosts A, and simultaneously, the volume and the weight of the host A are greatly optimized, so that the operation and the use are convenient, and the resource waste caused by repeated setting is avoided.

It should be further noted that, the host a includes the sampling arm X, the incubation disc measuring device J and the reagent supplying device S arranged in a row, the sampling arm X takes the reagent away from the reagent supplying device S and the sampling station, and the sample is put into the incubation disc measuring device J for incubation and testing, so that the operation executing mechanism in the host a is arranged on a straight line, the mechanism occupation space of the host a is reduced, the volume of the host a is reduced, the host a is more miniaturized, and the host a is beneficial to cascade use with the sample injector B. Wherein, arranged in a row means arranged in the same direction, for example, arranged in a straight line.

Fig. 2 is a schematic structural diagram of an injector B provided in an embodiment, which illustrates a preferred structure of the injector B in fig. 1, and the injector B is multifunctional, can efficiently feed samples back and forth, and is convenient for the cascade mainframe a to perform sampling inspection.

Fig. 3 is a partial structural schematic diagram of the sample injector B in fig. 2.

Referring to fig. 2 and 3, an injector B includes: the bottom plate B2, the reciprocating sample feeding subgroup B4 and at least one pre-sampling operation subgroup which are arranged on the bottom plate B2. The bottom plate B2 is provided with a sample to-be-detected area B3, the middle layer of the bottom plate B2 is provided with a board card placing position B13, and the board card placing position B13 is used for placing a sample injector board card and a mainboard card. The shuttle subgroup B4 is located on one side of the sample test zone B3 and is used to shuttle the sample rack loaded with sample tubes into the sample test zone B3. Wherein, the bottom end of the bottom plate B2 is provided with a non-slip pad B1. Preferably, the bottom plate B2 can be set up to be the bilayer structure including upper and lower two-layer, and the upper strata mainly is used for setting up the operation subgroup before the sample, and the lower floor can be used for placing sample injector integrated circuit board, host computer integrated circuit board and wire rod to use with the host computer is cascaded.

The bottom plate B2 is also provided with a sample recovery area B5 on one side of the reciprocating sample feeding subgroup B4 for recovering the sample rack after the examination is completed. At least one pre-sampling sub-group is located on one side of the reciprocating sample sub-group B4 for performing a pre-sampling operation on the sample. The side of the sample area to be tested B3 can be cascaded with at least two hosts a for sampling test. The pre-sampling operational subgroup includes, but is not limited to, loading subgroup B8, rotational scanning subgroup B6, shaking subgroup B7, top subgroup B11, unloading subgroup B9, and emergency feeding subgroup B10.

The loading subgroup B8 is used to advance the sample rack into the entrance of the reciprocating loading subgroup B4. The rotational scan subgroup B6 is used to read the identification information on the sample tube. The shaking subgroup B7 grabs the sample tube shaking sample for the host A to puncture the sample tube for sampling. The top tube set B11 moves forward to push against the sample tube for the host A to puncture for sampling. The unloading subgroup B9 is used to push the inspected sample rack into the sample recovery zone B5. The emergency sample introduction subgroup B10 is used for inserting a sample tube needing emergency detection into the sample region-to-be-detected B3.

In this embodiment, by providing the bottom plate B2, the reciprocating sample feeding subgroup B4 and at least one pre-sampling operation subgroup on the bottom plate B2, the bottom plate B2 is provided with the sample region to be measured B3, the reciprocating sample feeding subgroup B4 is located at one side of the sample region to be measured B3, for reciprocating transport of the sample rack carrying the sample tubes into the sample area to be tested B3, at least one pre-sampling subgroup located on one side of the reciprocating sub-group B4, for the pre-sampling operation of the sample, the side of the sample-to-be-detected region B3 can be cascaded with at least two hosts A for sampling detection, thereby realizing reciprocating and efficient sample feeding, integrating the separable pre-sampling operation subgroup originally integrated in the inspection equipment into the sample injector B, the automatic cascade host A is used for sampling and detecting samples, the detection efficiency is improved, the size and the weight of detection equipment are reduced, and the purposes that the sample injector B and the host A can be produced in a modularized mode and are matched with each other in a flow line type cascade mode are achieved.

Fig. 4 is a schematic structural diagram of the rotational scanning subgroup according to an embodiment, which shows a preferred structure of the rotational scanning subgroup.

Referring to fig. 4, the rotational scanning subgroup includes: a tube drawing mechanism L0, a rotating mechanism L1 and a scanning mechanism L2 which are arranged on the main substrate L4;

the tube drawing mechanism L0 and the rotating mechanism L1 are arranged on the same axis; the tube drawing mechanism L0 draws the sample tubes L6 and the rotating mechanism L1 with different tube diameters on the sample tube rack to be close to and clamped at the tube clamping station, the rotating mechanism L1 rotates to drive the clamped sample tubes L6 to rotate, and the scanning mechanism L2 is positioned on one side of the sample tubes L6 to scan and rotate the sample tube marks entering the identification area.

In this embodiment, a tube pulling mechanism L0, a rotating mechanism L1 and a scanning mechanism L2 are arranged on a main substrate L4, the tube pulling mechanism L0 is connected with the rotating mechanism L1, the tube pulling mechanism L0 pulls sample tubes L6 and rotating mechanism L1 with different tube diameters on a sample tube rack to be close to and clamped at a tube clamping station, the rotating mechanism L1 rotates to drive the clamped sample tubes L6 to rotate, the scanning mechanism L2 is located at one side of the sample tubes L6 to scan sample tube identifiers entering an identification area in a rotating manner, so that manually pasted identifiers can be rotationally aligned with the identification area of the scanning mechanism L2, the technical effect of accurate and rapid scanning is achieved, and meanwhile, the sample tubes L6 and rotating mechanism L1 with different tube diameters are close to and clamped at the tube clamping station, and the technical effect of wide application range is achieved.

It should be noted that, since the tube pulling mechanism L0 can pull the sample tubes L6 with different tube diameters on the sample tube rack and the rotating mechanism L1 to approach and clamp the tube clamping station, the technical effect of pulling the sample tubes L6 with different tube diameters can be achieved by controlling the pulling distance.

In addition, because rotary mechanism L1 is rotatory can drive the sample tube L6 of clamp tightly rotatory, consequently the information sign on the sample tube L6 always rotates the discernment district of scanning mechanism L2 and receives the scanning discernment to not only can avoid artifical counterpoint scanning, practice thrift the manpower and raise the efficiency, but also can avoid the problem that the scanning precision is low that artifical counterpoint is inaccurate to be led to. The information mark can be an information carrier such as a bar code.

In addition, the tube drawing mechanism L0 and the rotating mechanism L1 are arranged on the same axis, so that the whole structure of the rotary scanning subgroup is more compact, and the integration on the sample injector B is facilitated.

FIG. 5 is a schematic structural diagram of a tube drawing mechanism according to an embodiment, which shows a preferred structure of the tube drawing mechanism.

Referring to fig. 5, the tube pulling mechanism L0 includes a motor assembly L01 having one side mounted on the main substrate L4, a timing belt L02 sleeved with one end of the motor assembly L01, a linear slide rail L03 mounted on one side of the main substrate L4, and a tube pulling rack L04 slidably connected to the linear slide rail L03 and having one side fixed to the timing belt L02; one end of the timing belt L02 is connected to the same axis as the rotation mechanism L1.

Specifically, the contact position of the tube drawing rack L04 and the sample tube L6 is provided with a pair of tube drawing friction wheels L040 to contact with the side wall of the sample tube L6.

The tube drawing rack L04 pulls the sample tube L6 to grip the sample tube L1 together with the rotating mechanism L1, and the rotating mechanism L1 rotates to rotate the sample tube L6 between the tube drawing rack L04 and the rotating mechanism L1. Wherein, tube drawing frame L04 and rotary mechanism L1 all contact with the lateral wall of sample tube L6, drive sample tube L6 through rotatory frictional force and rotate.

In addition, the pair of tube pulling friction wheels L040 not only can generate friction with the sample tube L6, but also has a certain stabilizing and limiting effect on the sample tube L6.

Fig. 6 is a schematic structural diagram of a buffer mechanism according to an embodiment, which illustrates a buffer mechanism.

Referring to fig. 6, a buffer mechanism L5 is provided on the timing belt L02; the buffer mechanism L5 buffers the tube drawing stroke of the tube drawing mechanism L0 pulling the sample tube L6, so that the tube drawing mechanism L0 pulls the sample tube L6 which is different in tube diameter from the sample tube clamped by the rotating mechanism L1.

Specifically, the buffer mechanism L5 includes a compression spring L50, a buffer rotating shaft L51, a timing belt clamping block L52 and a timing belt clamping piece L53; compression spring L50 and timing belt clamp piece L52 are installed on buffering pivot L51, and timing belt clamp piece L52 and timing belt clamping piece L53 clamp hold-in range L02.

It should be noted that, the buffering mechanism L5 arranged on the synchronous belt L02 may enable the stroke of the synchronous belt L02 to have a certain elastic range, for example, the synchronous belt L02 may continue to transmit a short distance after transmitting to the limit stroke, so as to achieve the technical effect of buffering and driving the rotating mechanism L1 and the tube pulling mechanism L0 to clamp the sample tubes L6 with different tube diameters, thereby expanding the scanning application range.

In addition, since the buffer mechanism L5 is disposed on the timing belt L02, the additional arrangement of the buffer mechanism and the related supporting components can be avoided, so that the overall structure of the rotary scanning sub-group is more compact, and the integration on the sample injector B is facilitated.

Fig. 7 is a schematic structural diagram of the reciprocating sample feeding subunit according to an embodiment, which illustrates a preferred structure of the reciprocating sample feeding subunit.

Fig. 8 is a partial structure diagram of the reciprocating sample feeding subgroup.

Referring to fig. 7 and 8, the reciprocating sample feeding subgroup B4 comprises a belt 401, an accessory 402 is provided on the belt 401 to clamp the sample rack, a tension pulley group 41 is provided at one end of the belt 401, the tension pulley group 41 is provided with a fixed block 411 and a sliding shaft 412, and the sliding shaft 412 can slide in a central fine hole of the fixed block 411; two compression springs 413 are arranged on two sides of the sliding shaft 412, and a driven wheel 414 rigidly connected with the sliding shaft 411 is continuously tensioned by the elastic force of the compression springs 413; mounted on the shaft of the driven wheel 414 is a code wheel 415, the code wheel 415 engaging a contact light couple 416.

Fig. 9 is a schematic structural diagram of the emergency sample feeding set according to an embodiment, which shows a preferred structure of the emergency sample feeding set.

Referring to fig. 9, emergency sample set B10 includes emergency sample base 101 and emergency sample holder 102. The emergency sample holder 102 may be rotated about a rotation axis 106, with the angle of rotation being controlled by two pull-up springs 104, 105. When a user needs to urgently insert a sample, the electromagnetic spring 103 acts, the urgent sample holder 102 rotates a certain angle (for example, clockwise) under the combined action of the two pulling-up springs 104 and 105, and the user can conveniently place or take the urgent inserted sample. The angle of the two pull-up springs 104 and 105 is skillfully set, the rotation angle of the emergency sample holder 102 is increased, and the button force generated by the pull-up spring 105 is slowly larger than the torsion force generated by the pull-up spring 104. The rotating force of the emergency sample holder 102 is ensured to be smaller and smaller, and finally, the emergency sample holder stops reaching balance, so that the rotation can be stopped slowly, and the sample cannot spill out due to vibration in the rotating process. Finally, the user can manually reset the emergency sample holder 102 in the opposite direction, and the emergency sample holder 102 is stopped at the sample injection position under the action of the electromagnetic spring 103. At this time, the position optical coupler 107 mounted on the emergency sample inlet base 101 is triggered, and the emergency sample inlet base 102 is reset to normal.

Fig. 10 is a schematic structural diagram of the shake-up sub-group provided in an embodiment, showing a preferred structure of the shake-up sub-group.

Referring to fig. 10, the shake subset is small in size and easy to integrate with other mechanisms.

A shake-up sub-set comprising: an isolation case G0, a lifting module G1, a translation module G2 and a rotating arm G3; the isolation shell G0 comprises an outer shell G00 and an inner shell G01 positioned inside the outer shell G00, and a reserved space G4 for wiring is formed between the outer wall of the inner shell G01 and the inner wall of the outer shell G00;

the rotating arm G3 is arranged on the translation module G2; the lifting module G1 is connected with the outer shell G00 and the inner shell G01 and is used for driving the inner shell G01 to lift along the inner wall of the outer shell G00; the translation module G2 is arranged in the inner shell G01 and can translate to drive the rotating arm G3 to clamp the sample tube L6; rotating arm G3 may be used to spin-up the body fluid in sample tube L6 at a spin-up station.

In this embodiment, through setting up isolation shell G0, lift module G1, translation module G2 and rotation arm G3, isolation shell G0 includes outer shell G00 and the inner shell G01 that is located the inside of outer shell G00, the outer wall of inner shell G01 and the inner wall of outer shell G00 have the headspace G4 that is used for walking the line, rotation arm G3 is located on translation module G2, lift module G1 connects outer shell G00 and inner shell G01, be used for driving inner shell G01 to go up and down along the inner wall of outer shell G00, translation module G2 is located in inner shell G01 and can translate and drive rotation arm G3 to centre gripping sample tube L6, rotation arm G3 can shake up the body fluid in sample tube L6 in the even station rotation of shaking up, thereby realize shaking up the body fluid automatically. In addition, the lifting module G1, the translation module G2 and the mechanism of the three motion degrees that the swinging boom G3 constitutes wholly set up in shell G00, and headspace G4 is used for arranging the wire rod to make sample pipe L6 shake the complete machine of even subgroup and the mutual noninterference contact between the wire rod of the mechanism of its each motion degree, reach and easily shake even subgroup with sample pipe L6 and other mechanism integrated uses, reduce the technical effect that space and material occupy.

It should be noted that, since the isolation case G0 includes the outer case G00 and the inner case G01 located inside the outer case G00, the outer wall of the inner case G01 and the inner wall of the outer case G00 have a reserved space G4 for routing, and the inner case G01, the translation module G2 and the rotating arm G3 arranged in the inner case G01 are lifted and lowered in the outer case G00 as an integral structure, so that other objects outside the outer case G00 will not interfere with the integral structure. In addition, a reserved space G4 formed between the outer shell G00 and the inner shell G01 is used for planning and placing wires of the movement mechanisms such as the translation module G2 and the rotating arm G3, so that the movement mechanisms are not interfered with each other, and the mechanisms can be small in size as much as possible on the premise of ensuring that the movement of each degree of freedom is completed, and the technical effects of reducing space and material occupation and being easy to integrate with other mechanisms are achieved.

It should be further noted that, the translation module G2 can translate to drive the rotation arm G3 to clamp the sample tube L6, and the rotation arm G3 can rotate at the shake-up station to shake up the body fluid in the sample tube L6, so that the movement of the two degrees of freedom can complete the sampling of the sample tube L6 by the sample tube rack, move the sample tube L6 away from the sample tube rack, and then rise to the shake-up station along with the inner shell G01, and then the rotation arm G3 rotates to shake up the reagent in the sample tube L6, thereby achieving the technical effect of automatically shaking up the reagent.

Fig. 11 is a schematic structural diagram of the push pipe set according to an embodiment, which shows a preferred structure of the push pipe set.

Referring to fig. 11, the top tube set B11 has a sheet metal base 111, on which a linear slide rail 112 is disposed, and the top tube motor 117 drives the top tube-pushing block 113 to tightly push the sample tube L6 with larger movement on the sample rack, so that the position of the sample tube L6 can be accurately found when the puncture needle punctures. The push pipe motor 117 drives the slide block 115 to move forward to the top pipe by driving the belt, the slide block 115 can slide on the slide shaft 116 to move forward continuously, the compression spring 114 stops finally, the compression spring 114 will always process the compression state, and the push pipe block 113 will have the pressure for continuously pushing the sample pipe L6 tightly.

Fig. 12 is a schematic structural diagram of the sampling arm X according to an embodiment, which illustrates a preferred structure of the sampling arm X in fig. 1, and the sampling arm X has a compact volume, complete functions, and high performance efficiency.

Referring to fig. 12, a sampling arm X comprises: the translation module X1, puncture arm X2 and reagent arm X3 are respectively connected with the translation module X1 in a horizontal transmission manner and can vertically move for sample adding. Piercing arm X2 includes sample needle X20 and agitation and washing mechanism X21.

Stirring cleaning mechanism X21 is located the bottom of puncture arm X2, and sample needle X20 is located one side of puncture arm X2. The stirring and cleaning mechanism X21 can drive the sample needle X20 to stir the sample, and can spray cleaning liquid to clean the sample needle X20.

In this embodiment, by providing the translation module X1, the sample needle X20, and the stirring and cleaning mechanism X21, the puncture arm X2 and the reagent arm X3 are respectively connected to the translation module X1 in a horizontal transmission manner and can vertically move for sample loading, the puncture arm X2 includes the sample needle X20 and the stirring and cleaning mechanism X21, the stirring and cleaning mechanism X21 is disposed at the bottom end of the puncture arm X2, the sample needle X20 is disposed on one side of the puncture arm X2, the stirring and cleaning mechanism X21 can drive the sample needle X20 to stir a sample, and can spray a cleaning solution to clean the sample needle X20, so that a single translation module X1 can simultaneously load the puncture arm X2 and the reagent arm X3, and the volume of the device is reduced. Simultaneously, reagent arm X3 carries out the application of sample and the sample of reagent, and single puncture arm X2 set puncture, shake even, sample and cleaning function in an organic whole, has promoted the functional completeness of application of sample device, has practiced thrift the realization time of each function.

It should be noted that, because the puncture arm X2 that single translation module X1 loaded the sample application of liftable sample simultaneously and the reagent arm X3 of getting the reagent of liftable, because single puncture arm X2 set up puncture, shake even, sample and cleaning function in an organic whole again, consequently avoided separately setting up a plurality of translation modules X1 from structural, separately set up puncture mechanism, shake even mechanism, sampling mechanism and cleaning mechanism, reached the technological effect of simplifying the device volume.

In addition, because a single puncture arm X2 integrates puncture, shaking, sampling and cleaning functions, the functional completeness of the sample adding device is improved, and the realization time of each function is saved.

It should be noted that, since the puncturing arm X2 and the reagent arm X3 are horizontally and drivingly connected to the translation module X1, the translation module X1 can drive the puncturing arm X2 to move horizontally above the sample container, and drive the reagent arm X3 to move horizontally above the reagent container.

In addition, because both the puncture arm X2 and the reagent arm X3 can perform lifting movement, the puncture arm X2 above the sample container can descend to puncture the outer cover of the sample container, and then enter the sample container to shake up the sample for taking away, thereby realizing the technical effects of simplifying the volume of the device and improving the execution efficiency of puncturing, shaking up, sampling and the like. Meanwhile, the reagent arm X3 above the reagent container may be lowered into the reagent container (e.g., reagent cup) for reagent access. Wherein, the sample needle X20 can be driven by the stirring and cleaning mechanism X21 to stir the sample.

It should be noted that, since the sample needle X20 of the puncture arm X2 is used for puncturing, sampling and loading different samples, in order to avoid cross infection between samples, it is necessary to perform puncture needle cleaning after each puncture sampling and loading is completed.

Further, referring to fig. 12, the reagent arm X3 includes the reagent needle 30 and the stirring mechanism 3 b.

The stirring mechanism 3b is provided at the bottom end of the reagent arm X3. The reagent needle 30 is provided on one side of the reagent arm X3, and the stirring mechanism 3b can drive the reagent needle 30 to stir the reagent.

It should be noted that, because the stirring mechanism 3b at the bottom end of the reagent arm X3 can drive the reagent needle 30 to stir the reagent, it is avoided to manually stir the reagent or additionally set a separate stirring structure to stir the reagent, thereby achieving the technical effects of simplifying the volume of the device and improving the stirring execution efficiency.

Fig. 13 is a schematic structural diagram of an incubation tray measuring device J according to an embodiment, which illustrates a preferred structure of the incubation tray measuring device J in fig. 1, and the positions of the components of the incubation tray measuring device J are determined, so as to facilitate disassembly, assembly, maintenance and mass production.

Referring to fig. 13, an incubation tray measuring device J includes: the device comprises an integration plate J0, a rotating assembly J1, an incubation assembly J2, a measurement module J3 and a multi-stage cleaning assembly J4, wherein the rotating assembly J1, the incubation assembly J2, the measurement module J3 and the multi-stage cleaning assembly J4 are arranged on the integration plate J0; the rotating assembly J1 drives the incubation assembly J2 to rotate under the incubation assembly J2;

the measurement module J3 measures the sample value of the liquid in the reaction cup incubated in the incubation assembly J2 on the side of the incubation assembly J2; the multi-stage washing component J4 sucks the liquid in the reaction cup through the operation port of the incubation component J2 and washes the reaction cup.

In the embodiment, by arranging the integration plate J0, the rotating assembly J1, the incubation assembly J2, the measurement module J3 and the multistage cleaning assembly J4 which are arranged on the integration plate J0, the rotating assembly J1 drives the incubation assembly J2 to rotate under the incubation assembly J2, the measurement module J3 measures the sample value of liquid in a reaction cup incubated in the incubation assembly J2 at one side of the incubation assembly J2, and the multistage cleaning assembly J4 sucks the liquid in the reaction cup through an operation port of the incubation assembly J2 and then cleans the reaction cup, so that a plurality of assemblies are integrated on the integration plate J0 to complete corresponding functions, the positions of the assemblies are determined, and the assembly, the maintenance and the scale production are facilitated.

The board J0 is a board on which a plurality of functional components can be mounted. A plurality of functional components are integrated to form an integrated module after being integrated on the integrated board J0, modular production can be carried out, and disassembly, assembly and maintenance are facilitated. Meanwhile, the integrated module occupies a smaller space compared with the separated component, and is beneficial to unified management and use.

In addition, because the liquid in the reaction cup contains various components (such as fragments and fluid), the reaction cup is difficult to clean simply, and therefore the multistage cleaning assembly J4 is arranged, the reaction cup can be cleaned and cleaned according to a set sequence, for example, the fragments in the liquid are firstly sucked, then the fluid in the liquid is sucked, then the cleaning liquid is sprayed to clean the cup body, and finally the cup body is wiped and emptied.

The operation ports include, but are not limited to, a sample port J51, a liquid taking port J52, a cup taking guide groove J53, and a cleaning port J54.

The operation port is communicated with the reaction cup, and different operations can be carried out on the reaction cup through different operation ports. For example, the reaction cup can be cleaned in multiple stages through the cleaning port J54.

FIG. 14 is a schematic structural diagram of a multi-stage cleaning assembly according to an embodiment, showing a preferred structure of the multi-stage cleaning assembly. Fig. 15 is a schematic structural view of the cleaning pin set in fig. 14.

Referring to fig. 14 and 15, the multi-stage cleaning assembly J4 includes a lifting module J40 and a cleaning needle set J41 provided on the lifting module J40; the cleaning needle group J41 comprises a liquid injection and debris suction needle group, a liquid injection and liquid suction needle group and a negative pressure wiping needle group which are arranged side by side and sleeved with a compression spring buffer mechanism J42.

It should be noted that the lifting module J40 can drive the cleaning needle set J41 to the reaction cup J8, and the cleaning needle set J41 controls the liquid path to clean the reaction cup J8. The cleaning needle group J41 can be fixed on the manifold J0 through a triangular plate so as to ensure the perpendicularity of the cleaning needles and the working surface. The cleaning needle group J41 can be integrated into four groups of cleaning needles which can suck, discharge and wipe liquid. Because there may be puncture debris carried by the needles in the cuvette J8, the inner diameter of the first set of cleaning needles J410 may be sized according to the volume of debris in the cleaning sequence to suck and remove a significant portion of the debris. The inner diameter of the second and third groups of cleaning needles (J411, J412) can be manufactured according to the requirement of the liquid injection speed. The fourth set of cleaning needles J413 may be wiping needles of a single needle design to wipe and wick away water droplets. A liquid suction block J4130 is arranged under the fourth group cleaning needle J413, a liquid suction groove is arranged at the bottom, and the liquid suction groove is deep and manufactured according to the principle that water drops in the reaction cup J8 are emptied to the maximum extent.

Wherein, the big needle of the first group cleaning needle J413 is responsible for discharging debris and liquid, and the little needle is responsible for annotating the liquid and washing. The second and third groups of cleaning needles (J411, J412) are respectively provided with a liquid injection needle and a liquid injection and suction needle group, and liquid injection and suction are simultaneously carried out to clean the reaction cup. The reaction cup is kept with proper liquid, so that negative pressure is formed on the cup wall when the fourth group of wiping needles perform wiping action, the cup body is flushed, and the cup body is drained by the wiping needles after wiping and cleaning.

The four groups of cleaning needles are respectively provided with a compression spring buffer mechanism J42, so that all the cleaning needles are ensured to contact the bottom of the reaction cup J8, and the actions of sucking liquid, discharging liquid, wiping and the like are performed to the maximum extent.

FIG. 16 is a schematic structural diagram of a reagent supplying apparatus S according to an embodiment, which shows a preferred structure of the reagent supplying apparatus S, and the reagent supplying apparatus S is small in size, convenient to use, and high in operation efficiency.

Referring to fig. 16, 17 and 18, a reagent supplying apparatus S provided in a housing of an in vitro diagnostic apparatus includes: the refrigerator comprises a base S0, a belt conveying mechanism S1 arranged on the base S0, and a heating box S2 and a cooling box S3 which are in transmission connection with the belt conveying mechanism S1 respectively;

the heating box S2 and the refrigerating box S3 are respectively used for placing reagent bottles filled with different types of reagents at constant temperature, and the belt conveying mechanism S1 can drive the elastic reset door S4 arranged on the machine case to be pushed open to move to a reagent bottle replacing station outside the machine case.

In this embodiment, a reagent supply device S is disposed in a chassis of the in-vitro diagnostic apparatus, the reagent supply device S is disposed on a base S0, a belt conveying mechanism S1 disposed on the base S0, and a heating box S2 and a cooling box S3 respectively connected to the belt conveying mechanism S1 in a transmission manner, reagent bottles containing different types of reagents are respectively placed in the heating box S2 and the cooling box S3 at constant temperatures, and the belt conveying mechanism S1 can drive an elastic reset door S4 disposed on the chassis to be pushed open to move to a reagent bottle replacement station outside the chassis, so that the chassis of the in-vitro diagnostic apparatus does not need to be disassembled when the reagent bottles are replaced, the reagent bottles containing different types of reagents have a wide transmission speed range, high efficiency, accurate precision, no sliding, low noise, and vibration absorption buffering, thereby achieving the technical effects of the reagent supply device S that is small in size, convenient to use, and high in operation efficiency.

It should be noted that, because the belt conveying mechanism S1 drives the heating box S2 and the cooling box S3 to be connected, the belt conveying mechanism S1 can drive the heating box S2 and the cooling box S3 to move linearly to a set position, so as to operate different types of reagents and/or reagent bottles in the heating box S2 and the cooling box S3. For example, referring to fig. 17, the heating box S2 and the cooling box S3 are transported to a reagent bottle changing station outside the cabinet for reagent bottle changing.

For another example, referring to fig. 18, the heating box S2 and the cooling box S3 may be transported by the belt conveyor S1 to a sampling station in the cabinet, and the sampling arm X samples the reagent.

It should be further noted that, because the belt conveying mechanism S1 can drive the heating box S2 and the cooling box S3 to move linearly, and push open the elastic reset door S4 arranged on the case to move to the reagent bottle replacing station outside the case, the case of the external diagnostic apparatus does not need to be disassembled when replacing the reagent bottles, the reagent bottles filled with different types of reagents have wide range of conveying speed, high efficiency, accurate precision, no sliding, low noise and vibration absorption buffering, thereby realizing the technical effects of small size, convenient use and high operating efficiency of the reagent supply device S.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (7)

1. A sample analyzer, comprising: a host and an injector separate from the host; the sample injector is used for carrying out at least one sampling operation on the sample and then sending the sample to a sampling station; the sampling station is cascaded with the host to sample the sample;

the host comprises a sampling arm, an incubation disc measuring device and a reagent supply device which are arranged in a row; the sampling arm takes the reagent from the reagent supply device and the sampling station and puts the sample into the incubation disc measuring device for incubation test;

the sampler comprises a bottom plate, a reciprocating sample feeding subgroup arranged on the bottom plate and at least one pre-sampling operation subgroup, wherein the pre-sampling operation subgroup is integrated in the sampler to realize the sampling detection of the sample by the automatic cascade host; a sample region to be detected is arranged on the bottom plate;

the reciprocating sample feeding subgroup is positioned at one side of the sample region to be measured and is used for conveying a sample rack loaded with a sample tube into the sample region to be measured in a reciprocating manner; the at least one sub-group of pre-sampling operations is positioned at one side of the reciprocating sample feeding sub-group so as to perform the pre-sampling operations of the samples;

the pre-sampling operational subset comprises a rotational scan subset; the rotary scanning subgroup is used for reading identification information on the sample tube; the rotational scanning subgroup comprises: the tube drawing mechanism and the rotating mechanism are arranged on the same axis, the tube drawing mechanism draws the sample tube on the sample rack to be close to the rotating mechanism and clamps the sample tube on a tube clamping station, the rotating mechanism rotates to drive the clamped sample tube to rotate, and the scanning mechanism is used for scanning identification information of the sample tube which enters the identification area in a rotating mode;

the sampling arm comprises a translation module, a puncture arm and a reagent arm, wherein the puncture arm and the reagent arm are respectively connected with the translation module in a horizontal transmission manner and can vertically move for sample adding; the puncture arm comprises a sample needle and a stirring and cleaning mechanism; the stirring and cleaning mechanism is arranged at the bottom end of the puncture arm, and the sample needle is arranged on one side of the puncture arm; the stirring and cleaning mechanism can drive the sample needle to stir a sample, and can spray cleaning liquid to clean the sample needle.

2. The sample analyzer of claim 1, wherein the pre-sampling operational subset comprises a shake subset; the shaking group grabs the sample tube and shakes the sample for the host computer to puncture the sample tube for sampling.

3. The sample analyzer of claim 1, wherein the pre-sampling operational subset comprises a set of top tubes; the push pipe group moves forwards to prop against the sample pipe so as to be used for puncture sampling of the host.

4. The sample analyzer of claim 1, wherein the bottom plate is further provided with a sample recovery area on one side of the reciprocating sample feeding subgroup for recovering the sample rack after the test is completed; the pre-sampling operational subset comprises an unload subset; the unloading subgroup is used for pushing the sample rack after the test is completed into the sample recovery area.

5. The sample analyzer of claim 1, wherein the pre-sampling operational subset comprises an emergency sample subset; the emergency sample introduction sub-group is used for inserting a sample tube needing emergency detection into the sample region to be detected.

6. The sample analyzer of claim 1 wherein the incubation tray measurement device comprises: the device comprises an integrated plate, and a rotating assembly, an incubation assembly, a measurement module and a multi-stage cleaning assembly which are arranged on the integrated plate; the rotating assembly drives the incubation assembly to rotate below the incubation assembly;

the measurement module is used for measuring the sample value of liquid in a reaction cup incubated in the incubation assembly on one side of the incubation assembly; and the multistage cleaning assembly sucks the liquid in the reaction cup through the operation port of the incubation assembly, and then the operations of injecting cleaning liquid and sucking the liquid are carried out for multiple times to clean the reaction cup.

7. The sample analyzer of claim 1, wherein the reagent supply device comprises: the heating box and the refrigerating box are respectively in transmission connection with the belt conveying mechanism;

reagent bottles filled with different types of reagents are respectively placed in the heating box and the refrigerating box at constant temperature, and the belt conveying mechanism drives an elastic reset door arranged on a case of the main machine to be pushed open to move to a reagent bottle replacing station outside the case.

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