CN109283351B - Full-automatic blood coagulation analyzer - Google Patents

Full-automatic blood coagulation analyzer Download PDF

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Publication number
CN109283351B
CN109283351B CN201811344152.8A CN201811344152A CN109283351B CN 109283351 B CN109283351 B CN 109283351B CN 201811344152 A CN201811344152 A CN 201811344152A CN 109283351 B CN109283351 B CN 109283351B
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cup
reagent
sample
detection
groove
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CN201811344152.8A
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CN109283351A (en
Inventor
张金科
卢高波
童高明
刘希
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Beijing Strong Biotechnologies Inc
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Beijing Strong Biotechnologies Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system

Abstract

The invention relates to a full-automatic coagulation analyzer, which comprises a shell, wherein a reaction cup feeding system, a sample and reagent conveying system, a detection system, a sample position, a reagent position, a waste cup accommodating mechanism, a scanning system and a host system are arranged in the shell; the reaction cup feeding system receives the reaction cup from the outside through a cup inlet of the shell, so that the reaction cup is conveyed to the detection system; the sample and reagent delivery system is configured to deliver the sample and reagent from the sample site and the reagent site to the detection system; the waste cup accommodating mechanism is arranged to accommodate the reaction cup after detection from the detection system; the host system comprises a human-computer interaction module and a control module. The invention has the advantages that each functional system is reasonable in partition, the operation of each system is integrally controlled through a single host, no additional computer is required, the space is effectively utilized, the automatic detection operation is smoother, the detection speed is high, the operation is simple and rapid, the size is small, and the failure rate is low.

Description

Full-automatic blood coagulation analyzer
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a full-automatic coagulation analyzer.
Background
With the improvement of medical technology, coagulation analysis has been a routine analytical means in hospitals. Coagulation analyzers include fully automated coagulation analyzers and semi-automated coagulation analyzers. The semi-automatic blood coagulation analyzer needs to consume larger labor cost, has long testing time, and cannot meet the requirements of large quantity of test samples, quick test and the like. And a fully automated coagulation analyzer is suitable for testing of a large number of samples.
However, the existing fully automatic coagulation analyzer has some defects, the implementation method of the fully automatic coagulation analyzer adopts a fixed partition, and then blood samples and test reagents are injected, so that a plurality of motion systems are frequently operated between the fixed partitions in a crossed manner to complete the whole automatic detection process, the test speed of the whole analyzer is slow, and the whole system is bulky, difficult to control and high in failure rate.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Disclosure of Invention
The invention aims to provide a full-automatic coagulation analyzer, each functional system is reasonable in partition, the operation of each system is integrally controlled through a single host, no additional computer is required to be configured, the space is effectively utilized, the automatic detection operation is smoother, and the detection speed is high.
The purpose of the invention is realized by the following technical scheme:
a full-automatic coagulation analyzer comprises a shell, wherein a reaction cup feeding system, a sample and reagent conveying system, a detection system, a sample position, a reagent position, a waste cup receiving mechanism, a scanning system for scanning sample information and a host system for controlling the work of the full-automatic coagulation analyzer are arranged in the shell; the reaction cup feeding system receives reaction cups from the outside through cup inlet openings of the shell, so as to convey the reaction cups to the detection system; the sample and reagent delivery system is configured to deliver samples and reagents from the sample site and the reagent site to the detection system; the waste cup receiving mechanism is arranged to receive the reaction cup after detection from the detection system; the host system comprises a human-computer interaction module and a control module.
Preferably, the cuvette feeding system, the detection system, the sample site and the reagent site are all disposed at a lower portion of the housing, the cuvette feeding system is disposed at one side of the detection system, the sample site and the reagent site are disposed at the other side of the detection system opposite to the cuvette feeding system, and the sample and reagent delivery system is disposed at an upper portion of the housing and is movable between the detection system and the sample site and the reagent site.
Preferably, the reaction cup feeding system comprises a conveying groove, a connecting groove, a cup storage groove arranged on a cup storage bottom plate, a reaction cup pushing mechanism and a push rod; the connecting groove is arranged between the conveying groove and the cup storage bottom plate; the first end part of the conveying groove extends out of the shell through the cup inlet of the shell to receive the reaction cup, the second end part of the conveying groove is vertically jointed with the connecting groove, and a conveying belt is arranged in the conveying groove to convey the reaction cup from the first end part to the second end part; the cup storage groove is connected to the cup storage bottom plate in a sliding mode so as to slide on the cup storage bottom plate in parallel to the connecting groove, and when the cup storage groove slides to a position, close to the connecting groove, of the cup storage bottom plate, the cup storage groove is connected with the connecting groove; the reaction cup pushing mechanism is arranged close to the second end of the conveying groove so as to push the reaction cup positioned at the second end of the conveying groove into the cup storage groove through the connecting groove; the push rod is arranged close to the cup storage groove so as to push the reaction cup placed in the cup storage groove into the detection system.
Preferably, the conveying belt in the conveying groove is driven by a first stepping motor, the reaction cup pushing mechanism comprises a support plate, a transmission belt arranged on the support plate and a reaction cup pushing rod driven by the transmission belt, the transmission belt is driven by a second stepping motor, the transmission belt extends from the upper part of the second end part of the conveying groove to the upper part of the position, connected with the connecting groove, of the storage cup bottom plate, and the reaction cup pushing rod is connected with the transmission belt through a connecting frame so as to push the reaction cup from the conveying groove to the storage cup groove through the reaction cup pushing rod.
Preferably, a reaction cup sensor is arranged at the second end of the conveying trough to sense whether the reaction cup reaches the second end of the conveying trough; the reaction cup pushing rod is arranged in the reaction cup storage groove, the top of the support plate is provided with two position sensors for respectively sensing whether the reaction cup pushing rod reaches an initial position and a result position, the initial position is the position where the reaction cup pushing rod is located when the reaction cup pushing rod starts to push a reaction cup, and the result position is the position where the reaction cup pushing rod is located when the reaction cup pushing rod pushes the reaction cup into the cup storage groove.
Preferably, a sliding rail is arranged on the cup storage bottom plate, a sliding groove matched with the sliding rail is arranged at the bottom of the cup storage groove, the cup storage groove is driven by a third stepping motor, and the cup storage groove is connected with a motor driving plate of the third stepping motor to slide on the cup storage bottom plate.
Preferably, the push rod for pushing the reaction cup in the cup storage groove into the detection system is slidably connected with the motor drive plate through a connecting moving block, the push rod is connected with the connecting moving block and can move relative to the connecting moving block, the push rod is driven by a lead screw motor connected with the connecting moving block, and the cup storage groove, the connecting moving block, the push rod and the lead screw motor are integrally driven by the third stepping motor to integrally move along the cup storage bottom plate.
Preferably, the detection system comprises a detection bracket, a heating bottom plate connected to the top of the detection bracket, and a detection channel connected to the heating bottom plate, the detection channel is connected to the cuvette feeding system through a slide way so that a cuvette enters the detection channel from the cuvette feeding system, a light-emitting circuit board is arranged on a first side of the detection channel to irradiate a sample and a reagent in the cuvette with light, a detection circuit board is arranged on a second side of the detection channel opposite to the first side to collect optical data of the sample and the reagent in the cuvette, and an overheat protection switch is arranged on the heating bottom plate to control the temperature of the heating bottom plate within a predetermined range.
Preferably, the first side and the second side of the detection channel are respectively provided with a light emitting circuit board cover and a detection circuit board cover.
Preferably, a fixing spring piece is arranged on the inner side wall of the channel groove of the detection channel so as to fix the reaction cup in the channel groove.
Preferably, the light-emitting circuit board is fixed on the outer side wall of the first side of the detection channel, and a light-transmitting hole is formed in the side wall of the first side of the detection channel.
Preferably, a heating sheet is arranged at the position, corresponding to the detection channel, of the bottom of the heating bottom plate.
Preferably, the detection circuit board is disposed on an outer sidewall of the second side of the detection channel.
Preferably, the sample and reagent delivery system comprises a first moving arm, a second moving arm, a sample needle and a reagent needle, the second moving arm is slidably connected to the first moving arm to be movable relative to the first moving arm between the sample site and the reagent site, the sample needle is connected to a side of the second moving arm near the sample site, the reagent needle is connected to a side of the second moving arm near the reagent site, the sample needle and the reagent needle are each movable up and down relative to the second moving arm, the first moving arm is slidably connected to a rear inner side wall of the housing by a slide plate to move the first moving arm in a transverse direction of the rear inner side wall, thereby moving the sample needle and the reagent needle between the sample site and the reagent site and the detection system.
Preferably, the device further comprises a cleaning position for cleaning the sample needle and the reagent needle, and a cleaning liquid pipeline outside the housing enters the housing through a pipeline interface on the housing to be connected with the sample needle and the reagent needle, so that the sample needle and the reagent needle are cleaned at the cleaning position.
Preferably, the reagent needle is provided with a preheating module to preheat the reagent needle.
Preferably, the waste cup accommodating mechanism includes a waste cup accommodating box provided at a position of the lower portion of the housing close to the detection system through an accommodating box drawer.
Preferably, the wireless communication module is further included to communicate with other devices to output the detection result.
Preferably, the upper portion of the housing is provided with a cover capable of opening the inner space of the housing.
The invention has the beneficial effects that:
1. the full-automatic coagulation analyzer has the advantages that each functional system is reasonable in partition, the operation of each system is integrally controlled through a single host, no additional computer is needed, the space is effectively utilized, the automatic detection operation is smoother, the detection speed is high, the detection speed PT (T/h) is more than or equal to 360T/h, the operation is simple and rapid, the size is small, and the failure rate is low.
2. Full-automatic application of sample, the liquid route is simple, and the reagent needle has solitary heating module, can preheat the reagent needle, therefore reagent need not incubate alone before getting into the reagent needle, practices thrift the reagent quantity, improves and detects accuracy and detection speed.
3. The detection system is controlled at a constant temperature within a range of 37 +/-5 ℃, and the detection accuracy is improved.
4. The reaction cup feeding system adopts single cups to load in bulk, which is beneficial to saving cost, has compact cup feeding space, is convenient for detecting time sequence design, and has more flexible inspection project planning.
5. The whole machine only uses one set of detection module, so that the cost is low and the reliability is high; all current detection methods are covered: coagulation, chromogenic substrate, immunoturbidimetry, latex agglutination; the detection speed of the combined project is greatly improved.
Drawings
FIG. 1 is a schematic structural diagram of a fully automatic coagulation analyzer according to an embodiment of the present invention;
FIG. 2 is a schematic structural view of a reaction cup feeding system according to an embodiment of the present invention;
FIG. 3 is a schematic view of a connection structure of a motor drive plate, a cup storage groove, a push rod, a connection moving block and a lead screw motor according to an embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a detection system according to an embodiment of the present invention;
FIG. 5 is a front view of one of the detection channels in the detection system according to the embodiment of the present invention.
Description of reference numerals:
1-reaction cup feeding system; 2-a touch display screen; 3-a first moving arm; 4-a second moving arm; 5-a pipeline bracket; 6-a sliding plate; 7-a sample needle; 8-reagent needle; 9-a detection system; 10-a cleaning position; 11-normal temperature reagent site; 12-cool reagent site; 13-a line interface; 14-a scanning system; 15-normal sample position; 16-emergency sample position; 17-a waste cup storage box; 18-a receiver drawer; 19-a housing;
101-reaction cup correcting device; 102 a conveyor belt; 103-a conveying trough; 104-reaction cup; 105-a first stepper motor; 106-reaction cup sensor; 107-guide shaft; 108-a position sensor; 109-reaction cup push rod; 110-a connecting trough; 111-a second stepper motor; 112-storage cup bottom plate; 113-a third stepper motor; 114 a cup storage tank; 115-lead screw motor; 116-a push rod; 117-motor drive plate; 118-a guide strip; 119-connecting the moving block; 120-a first track; 121-a second track; 122-a shaft rod; 123-drive plate connection;
901-heating the soleplate; 902-overheat protection switch; 903-light emitting circuit board cover; 904-light emitting circuit board; 905-a slide way; 906-detection channel; 907-detecting the circuit board; 908-detection circuit board cover; 909-fixed spring leaf; 910-heating plate; 911-a circuit motherboard; 912-circuit board.
It is to be understood that the appended drawings are not to scale, but are merely drawn with appropriate simplifications to illustrate various features of the basic principles of the invention. Specific design features of the invention disclosed herein, including, for example, specific dimensions, orientations, locations, and configurations, will be determined in part by the particular intended application and use environment.
In the several figures of the drawings, identical or equivalent components (elements) are referenced with the same reference numerals.
Detailed Description
The invention is further described with reference to specific embodiments and accompanying drawings.
As shown in fig. 1, the fully automatic blood coagulation analyzer according to the embodiment of the present invention includes a housing 19, wherein the housing 19 is provided with a cuvette feeding system 1, a sample and reagent conveying system, a detection system 9, a sample position, a reagent position, a waste cup receiving mechanism, a scanning system 14 for scanning sample information, and a host system for controlling the operation of the fully automatic blood coagulation analyzer according to the present invention; the reaction cup feeding system 1 receives reaction cups from the outside through a cup inlet of the housing 19, thereby conveying the reaction cups to the detection system 9; the sample and reagent delivery system is arranged to deliver samples and reagents from a sample site and a reagent site to the detection system 9; the waste cup accommodating mechanism is arranged to accommodate the reaction cup after detection from the detection system 9; the host system comprises a human-computer interaction module and a control module.
Wherein the cuvette feed system 1, the measuring system 9, the sample site and the reagent site are all arranged at a lower part of the housing 19, the cuvette feed system 1 is arranged at one side of the measuring system 9, the sample site and the reagent site are arranged at the other side of the measuring system 9 opposite to the cuvette feed system 1, and the sample and reagent delivery system is arranged at an upper part of the housing 19 and is movable between the measuring system 9 and the sample site and the reagent site.
In this example, the human-computer interaction module is a human-computer interaction touch display screen 2.
The full-automatic coagulation analyzer has the advantages that each functional system is reasonable in partition, the operation of each system is integrally controlled through a single host, no additional computer is needed, the space is effectively utilized, the automatic detection operation is smoother, the detection speed is high, the detection speed PT (T/h) is more than or equal to 360T/h, the operation is simple and rapid, the size is small, and the failure rate is low.
The sample sites of the fully automatic coagulation analyzer of the present invention include an emergency sample site 16 and a normal sample site 15, and the control module of the host system will preferentially process the blood samples in the emergency sample site 16 according to the settings of the host system. The scanning module is positioned adjacent to the sample site and is scanned for information by scanning system 14 prior to placing the sample in the sample site.
The reagent site comprises a normal temperature reagent site 11 and a cooling reagent site 12, and the corresponding reagent site can be selectively placed according to different temperature requirements of reagents. The cooling module arranged on the cooling reagent position 12 can ensure that the temperature of the cooling reagent position 12 is controlled to be less than or equal to 10 ℃.
As shown in fig. 2 and 3, the reaction cup feeding system 1 of the present invention comprises a conveying trough 103, a connecting trough 110, a cup storage trough 114 provided on a cup storage bottom plate 112, a reaction cup pushing mechanism and a push rod 116, the connecting trough 110 being provided between the conveying trough 103 and the cup storage bottom plate 112; a first end of the conveying groove 103 extends out of the shell 19 through the cup inlet of the shell 19 to receive the reaction cup 104, a second end of the conveying groove 103 is vertically jointed with the connecting groove 110, and a conveying belt 102 is arranged in the conveying groove 103 to convey the reaction cup 104 from the first end to the second end; the cup storage slot 114 is slidably coupled to the cup storage base 112 to slide on the cup storage base 112 parallel to the coupling slot 110, the cup storage slot 114 engaging the coupling slot 110 when the cup storage slot 114 slides to a position of the cup storage base 112 adjacent to the coupling slot 110; the cuvette pushing mechanism is provided near the second end of the transfer chute 103 to push the cuvette 104 located at the second end of the transfer chute 103 into the cuvette storage tank 114 via the connection tank 110, and the push rod 116 is provided near the cuvette storage tank 114 to push the cuvette 104 placed in the cuvette storage tank 114 into the detection system 9.
In this example, a cuvette correcting device 101 is provided at the first end of the conveying trough 103 to correct the cuvettes 104 entering the system, and the bottom of the conveying trough 103 is provided with a guide strip 118 along the length direction of the conveying trough 103, and the bottom of the cuvette 104 is provided with a guide groove matched with the guide strip 118, so that the cuvette 104 can be stably conveyed in the conveying trough 103 by matching the guide strip 118 with the guide groove, and the tilting or skew of the cuvette during the conveying process can not occur. The conveyor belt 102 in the conveyor chute 103 is driven by a first stepping motor 105.
The reaction cup pushing mechanism comprises a support plate, a transmission belt arranged on the support plate and a reaction cup pushing rod 109 driven by the transmission belt, the transmission belt is driven by a second stepping motor 111, the transmission belt extends from the upper part of the second end part of the conveying groove 103 to the upper part of the position, connected with the connecting groove 110, of the storage cup bottom plate 112, and the reaction cup pushing rod 109 is connected with the transmission belt through a connecting frame so as to push the reaction cup from the conveying groove 103 to the storage cup groove 114 through the reaction cup pushing rod 109.
Wherein a reaction cup sensor 106 is arranged at the second end of the conveying trough 103 to sense whether a reaction cup reaches the second end of the conveying trough 103; the top of the support plate is provided with two position sensors 108 for respectively sensing whether the reaction cup push rod 109 reaches an initial position and a result position, the initial position is the position of the reaction cup push rod 109 when the reaction cup push rod 109 starts to push the reaction cup, and the result position is the position of the reaction cup push rod 109 when the reaction cup push rod 109 pushes the reaction cup into the cup storage groove 114.
In this case, the support plate is further provided with a guide shaft 107 parallel to the belt, and the guide shaft 107 passes through the link bracket connected to the cuvette push bar 109 such that the link bracket can move along the guide shaft 107 to guide the cuvette push bar 109.
A sliding rail is arranged on the cup storage bottom plate 112, a sliding groove matched with the sliding rail is arranged at the bottom of the cup storage groove 114, the cup storage groove 114 is driven by a third stepping motor 113, and the cup storage groove 114 is connected with a motor driving plate 117 of the third stepping motor 113 so as to slide between a position on the cup storage bottom plate 112, which is connected with the connecting groove 110, and a position on the cup storage bottom plate 112, which corresponds to the detection system 9.
When the reaction cup sensor 106 senses that the reaction cup has reached the second end of the conveying trough 103, the reaction cup pushing rod 109 in the initial position starts to push the reaction cup towards the connecting trough 110 under the driving of the driving belt, at this time, the cup storage trough 114 has slid on the cup storage bottom plate 112 to the position of engaging with the connecting trough 110, and the reaction cup pushing rod 109 pushes the reaction cup through the connecting trough 110 until the reaction cup is pushed into the cup storage trough 114. The position sensor 108 senses that the reaction cup pushing rod 109 has reached a position where the reaction cup is completely pushed into the cup storage well 114, and the control module controls the reaction cup pushing rod 109 to stop pushing for resetting (returning to the initial position to prepare for pushing the next reaction cup). The cup storage tank 114 loaded with reaction cups slides along the cup bottom plate 112 to a position corresponding to the detection system 9, and after the reaction cups are pushed into the detection system 9, the empty cup storage tank 114 returns to a position engaged with the connecting tank 110 to wait for receiving the next reaction cup.
The reaction cup feeding system 1 adopts single cup loading in bulk, which is beneficial to saving cost, compact in cup feeding space, convenient for detection time sequence design and more flexible in inspection project planning.
In this case, the bottom of the coupling groove 110 has a slope inclined toward the cup bottom plate 112 so that the reaction cups can be more smoothly introduced into the cup storage groove 114.
As shown in fig. 3, a push rod 116 for pushing the cuvette in the cuvette storage tank 114 into the detection system 9 is slidably connected to a motor driving plate 117 through a connecting moving block 119, the push rod 116 is connected to the connecting moving block 119 and is movable relative to the connecting moving block 119, the push rod 116 is driven by a lead screw motor 115 connected to the connecting moving block 119, and the cuvette storage tank 114, the connecting moving block 119, the push rod 116, and the lead screw motor 115 are integrally driven by a third stepping motor 113 to integrally move along the cuvette base plate 112.
A lead screw of the lead screw motor 115 is connected with a connecting moving block 119, a first track 120 is arranged on a drive plate connecting piece 123 of the motor drive plate 117, a first track groove matched with the first track 120 is arranged on the side surface of the connecting moving block 119, and the lead screw motor 115 drives the connecting moving block 119 to slide along the first track 120 so as to drive the push rod 116 to move along the direction of pushing out the reaction cup in the cup storage groove 114; the lower portion of the push rod 116 is provided with a second track 121 perpendicular to the first track 120, the bottom of the connecting moving block 119 is provided with a second track groove engaged with the second track 121, and the push rod 116 is slidably connected to the connecting moving block 119 so that the push rod 116 can slide relative to the connecting moving block 119.
The push rod 116 is provided with a shaft rod 122 parallel to the second track 121, the connecting moving block 119 is provided with a mounting hole matched with the shaft rod 122, the shaft rod 122 passes through the mounting hole and can move in the mounting hole along the axial direction of the shaft rod 122, and the shaft rod 122 is provided with a spring (not shown in the figure) positioned between the push rod 116 and the connecting moving block 119.
In order to push the reaction cups in the cup storage groove 114, the push rod 116 is arranged to be aligned with the notch of the cup storage groove 114, the motor drive board 117 drives the cup storage groove 114 and the push rod 116 to move towards the connecting groove 110 together to align the cup storage groove 114 with the connecting groove 110, at this time, the push rod 116 interferes with the connecting groove 110 to be mutually interfered, as the motor drive board 117 drives the cup storage groove 114 to move towards the connecting groove 110, the connecting groove 110 pushes the push rod 116 towards the direction close to the connecting moving block 119, the push rod 116 moves towards the connecting moving block 119, the spring is compressed, when the cup storage groove 114 is loaded with the reaction cups to move towards the direction far away from the connecting groove 110, and the push rod is restored to the position aligned with the notch of the cup storage groove under the restoring force of the spring.
As shown in fig. 4 and 5, the detecting system 9 includes a detecting support, a heating bottom plate 901 connected to the top of the detecting support, and a detecting channel 906 connected to the heating bottom plate 901, the detecting channel 906 is connected to the cuvette feeding system 1 through a slide 905 to allow the cuvette to enter the detecting channel 906 from the cuvette feeding system 1, a first side of the detecting channel 906 is provided with a light emitting circuit board 904 to irradiate the sample and the reagent in the cuvette with light, a second side of the detecting channel 906 opposite to the first side is provided with a detecting circuit board 907 to perform optical data collection on the sample and the reagent in the cuvette, and the heating bottom plate 901 is provided with an overheat protection switch 902 to control the temperature of the heating bottom plate 901 within a predetermined range. The constant temperature is controlled within the range of 37 +/-5 ℃, and the detection accuracy is improved.
The first side and the second side of the detection channel 906 are provided with a light emitting circuit board cover 903 and a detection circuit board cover 908, respectively.
The detection channel 906 has a fixing spring piece 909 provided on an inner side wall of the channel groove to fix the cuvette in the channel groove.
The light emitting circuit board 904 is fixed on the outer side wall of the first side of the detection channel 906, and a light hole (not shown in the figure) is arranged on the side wall of the first side of the detection channel 906.
The detection circuit board 907 is disposed on an outer sidewall of the second side of the detection channel 906.
A circuit board 911 and a circuit board 912 for the inspection system 9 are provided on the inspection bracket.
In this embodiment, the detection system 9 has four detection channels 906, so that at most four cuvettes can be placed in the detection system 9 at a time, each cuvette has four detection positions, and one cuvette can hold four samples, so that the detection system 9 can detect at most sixteen samples at a time.
The bottom of the heating bottom plate 901 is provided with four heating sheets 910 at positions corresponding to the detection channels 906, in this example, four detection channels 906 are provided, and the bottom of the heating bottom plate 901 is provided with four corresponding heating sheets 910.
In this example, the number of the detection channels is illustrated as four, but the number of the detection channels is not limited thereto, and the number of the detection channels can be selected according to actual needs.
The detection system 9 is connected with the reaction cup feeding system 1 through a slide way 905, the slide way 905 comprises two parts, the reaction cup can be better transited to the detection system 9 through the inclined gradient of the part close to the reaction cup feeding system 1, the reaction cup can more easily enter the detection channel 906 through the part close to the detection channel 906 of the slide way 905, the reaction cup entering the detection channel 906 is added with a sample and a reagent through a sample and reagent conveying system, the sample and the reagent are irradiated through an LED lamp, and then optical data acquisition is carried out to obtain a detection result. Light-emitting circuit board 904 is a light-emitting diode (LED) circuit board, and each detection position supports multi-wavelength detection by using an LED lamp and a filter, thereby improving detection anti-interference capability and accuracy.
As shown in fig. 1, the sample and reagent delivery system includes a first moving arm 3, a second moving arm 4, a sample needle 7 and a reagent needle 8, the second moving arm 4 is slidably connected to the first moving arm 3 so as to be movable between the sample site and the reagent site with respect to the first moving arm 3, the sample needle 7 is attached to the second moving arm 4 on the side near the sample site, the reagent needle 8 is attached to the second moving arm 4 on the side near the reagent site, both the sample needle 7 and the reagent needle 8 are movable up and down with respect to the second moving arm 4, the first moving arm 3 is slidably coupled to a rear inner sidewall of the housing 19 by a sliding plate 6 to move the first moving arm 3 in a transverse direction of the rear inner sidewall, thereby moving the sample needle 7 and the reagent needle 8 between the sample site and the reagent site and the detection system 9.
The first moving arm 3 is fixed on a sliding plate 6, the sliding plate 6 is connected with a sliding rail on the inner side wall of the rear part of the shell 19 in a sliding way, in fig. 1, the first moving arm 3 slides in the left-right direction, the second moving arm 4 can also be connected with the first moving arm 3 by the cooperation of the slide rail and the slide groove, thereby causing the second moving arm 4 to slide relative to the first moving arm 3, the length of the first moving arm 3 in the front-rear direction in fig. 1 spanning the sample site and the reagent site, the second moving arm 4 to move relative to the first moving arm 3 in the front-rear direction, that is, between the sample site and the reagent site, the sample needle 7 takes a sample at the sample site and the reagent needle 8 takes a reagent at the reagent site by the movement of the second moving arm 4, the movement of the first moving arm 3 allows the sample needle 7 and the reagent needle 8 to come to the detection system 9 to discharge the sample and the reagent into the detection system 9 for detection. The sample needle 7 and the reagent needle 8 are each movable up and down with respect to the second moving arm 4 to facilitate taking of a sample and a reagent and discharging of the sample and the reagent.
As shown in fig. 1, the fully automatic coagulation analyzer of the present invention further includes a cleaning station 10 for cleaning the sample needle 7 and the reagent needle 8, and a cleaning liquid line outside the housing 19 enters the housing 19 through a line port 13 on the housing 19 to connect the sample needle 7 and the reagent needle 8, so that the sample needle 7 and the reagent needle 8 are cleaned at the cleaning station 10. A line support 5 for supporting the line is provided in the housing 19. The sample needle 7 and the reagent needle 8 need to be cleaned after completion of sampling the specimen and the reagent and discharging the specimen and the reagent, in preparation for the next operation.
In this example, the reagent needle 8 is provided with a preheating module to preheat the reagent needle 8. To the reagent that needs pre-rising temperature, can heat up reagent needle 8 through the module of preheating of reagent needle 8, wait that the reagent extracts and just can heat up reagent through the reagent needle 8 of preheating in the reagent needle 8, and need not additionally incubate alone (the intensification) to the reagent, improved work efficiency.
The waste cup containing mechanism includes a waste cup containing box 17, and the waste cup containing box 17 is provided at a position close to the detection system 9 on the lower portion of the housing 19 through a storage box drawer 18. In the detection system 9, a new cuvette comes in to replace a detected cuvette, the new cuvette pushes the detected cuvette out of the detection channel 906, the detected cuvette directly falls into the waste cup storage box 17, and then is taken out of the housing 19 through the storage box drawer 18.
The fully automatic coagulation analyzer according to the present invention further comprises a wireless communication module to communicate with other devices for outputting the detection result.
According to an embodiment of the present invention, the upper portion of the housing 19 is provided with a cover capable of opening the inner space of the housing 19.
When the full-automatic coagulation analyzer is used for detection, detection items are set through a human-computer interaction touch display screen 2, an empty reaction cup 104 enters a reaction cup feeding system 1 from a cup inlet, the reaction cup 104 is pushed to a cup storage groove 114 from a conveying groove 103 by a reaction cup pushing rod 109, the cup storage groove 114 slides to a position close to a detection system 9 on a cup storage bottom plate 112, the push rod 116 pushes the reaction cup in the cup storage groove 114 to a detection channel 906 through a slide way 905, the empty reaction cup is conveyed to the detection system 9 by the reaction cup feeding system 1, the sample to be detected and a required reagent are added into the reaction cup feeding system through the sample and reagent conveying system after the reaction cup enters the detection channel 906 of the detection system 9, and after the detection is finished, the newly-entered reaction cup pushes the detected reaction cup into a waste cup accommodating box 17. The detection result can be sent to other equipment through the wireless communication module to be printed and output.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. The foregoing description is not intended to be exhaustive or to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable others skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications thereof. It is intended that the scope of the invention be defined by the following claims and their equivalents.

Claims (17)

1. A full-automatic coagulation analyzer is characterized by comprising a shell, wherein a reaction cup feeding system, a sample and reagent conveying system, a detection system, a sample position, a reagent position, a waste cup receiving mechanism, a scanning system for scanning sample information and a host system for controlling the work of the full-automatic coagulation analyzer are arranged in the shell; the reaction cup feeding system receives reaction cups from the outside through cup inlet openings of the shell, so as to convey the reaction cups to the detection system; the sample and reagent delivery system is configured to deliver samples and reagents from the sample site and the reagent site to the detection system; the waste cup receiving mechanism is arranged to receive the reaction cup after detection from the detection system; the host system comprises a human-computer interaction module and a control module;
the reaction cup feeding system comprises a push rod and a cup storage groove arranged on a cup storage bottom plate, and the push rod is arranged close to the cup storage groove so as to push the reaction cup placed in the cup storage groove into the detection system;
a sliding rail is arranged on the cup storage bottom plate, a sliding groove matched with the sliding rail is arranged at the bottom of the cup storage groove, the cup storage groove is driven by a third stepping motor, and the cup storage groove is connected with a motor driving plate of the third stepping motor so as to slide on the cup storage bottom plate;
the push rod is connected with the motor driving plate in a sliding mode through a connecting moving block, the push rod is connected with the connecting moving block and can move relative to the connecting moving block, the push rod is driven through a lead screw motor connected with the connecting moving block, and the cup storage groove, the connecting moving block, the push rod and the lead screw motor are integrally driven through the third stepping motor to integrally move along the cup storage bottom plate.
2. The fully automated coagulation analyzer of claim 1, wherein the cuvette feed system, the detection system, the sample site and the reagent site are all disposed in a lower portion of the housing, the cuvette feed system is disposed on one side of the detection system, the sample site and the reagent site are disposed on an opposite side of the detection system from the cuvette feed system, and the sample and reagent delivery system is disposed in an upper portion of the housing and is movable between the detection system and the sample site and the reagent site.
3. The fully automated coagulation analyzer according to claim 1 or 2, wherein the cuvette feeding system further comprises a transfer groove, a connection groove, and a cuvette pushing mechanism; the connecting groove is arranged between the conveying groove and the cup storage bottom plate; the first end part of the conveying groove extends out of the shell through the cup inlet of the shell to receive the reaction cup, the second end part of the conveying groove is vertically jointed with the connecting groove, and a conveying belt is arranged in the conveying groove to convey the reaction cup from the first end part to the second end part; the cup storage groove is connected to the cup storage bottom plate in a sliding mode so as to slide on the cup storage bottom plate in parallel to the connecting groove, and when the cup storage groove slides to a position, close to the connecting groove, of the cup storage bottom plate, the cup storage groove is connected with the connecting groove; the reaction cup pushing mechanism is arranged close to the second end of the conveying groove so as to push the reaction cup positioned at the second end of the conveying groove into the cup storage groove through the connecting groove.
4. The fully automated coagulation analyzer of claim 3, wherein the transport belt in the transport trough is driven by a first stepper motor, the reaction cup pushing mechanism comprises a support plate, a transmission belt disposed on the support plate, and a reaction cup pushing rod driven by the transmission belt, the transmission belt is driven by a second stepper motor, the transmission belt extends from above the second end of the transport trough to above a position of the storage cup bottom plate engaged with the connection groove, and the reaction cup pushing rod is connected with the transmission belt through a connecting frame to push a reaction cup from the transport trough into the storage cup trough through the reaction cup pushing rod.
5. The fully automated coagulation analyzer of claim 4, wherein a cuvette sensor is provided at the second end of the transfer slot to sense whether a cuvette has reached the second end of the transfer slot; the reaction cup pushing rod is arranged in the reaction cup storage groove, the top of the support plate is provided with two position sensors for respectively sensing whether the reaction cup pushing rod reaches an initial position and a result position, the initial position is the position where the reaction cup pushing rod is located when the reaction cup pushing rod starts to push a reaction cup, and the result position is the position where the reaction cup pushing rod is located when the reaction cup pushing rod pushes the reaction cup into the cup storage groove.
6. The automatic coagulation analyzer according to claim 1 or 2, wherein the detection system comprises a detection support, a heating bottom plate connected to the top of the detection support, and a detection channel connected to the heating bottom plate, the detection channel is connected to the cuvette feeding system through a slide way so that a cuvette enters the detection channel from the cuvette feeding system, a light-emitting circuit board is disposed on a first side of the detection channel to irradiate a sample and a reagent in the cuvette with light, a detection circuit board is disposed on a second side of the detection channel opposite to the first side to perform optical data acquisition on the sample and the reagent in the cuvette, and an overheat protection switch is disposed on the heating bottom plate to control the temperature of the heating bottom plate within a predetermined range.
7. The fully automated coagulation analyzer of claim 6, wherein the first side and the second side of the detection channel are provided with a light emitting circuit board cover and a detection circuit board cover, respectively.
8. The automatic coagulation analyzer of claim 6, wherein a fixing spring piece is provided on an inner sidewall of the channel groove of the detection channel for fixing the reaction cup in the channel groove.
9. The automatic coagulation analyzer of claim 6, wherein the light emitting circuit board is fixed on an outer sidewall of the first side of the detection channel, and a light hole is provided on the sidewall of the first side of the detection channel.
10. The automatic coagulation analyzer of claim 6, wherein a heating sheet is disposed at a position corresponding to the detection channel at the bottom of the heating substrate.
11. The fully automated coagulation analyzer of claim 6, wherein the detection circuit board is disposed on an exterior sidewall of the second side of the detection channel.
12. The fully automated coagulation analyzer of claim 1 or 2, wherein the sample and reagent delivery system comprises a first moving arm, a second moving arm, a sample needle and a reagent needle, the second moving arm is slidably connected to the first moving arm so as to be movable relative to the first moving arm between the sample site and the reagent site, the sample needle is connected to a side of the second moving arm near the sample site, the reagent needle is connected to a side of the second moving arm near the reagent site, the sample needle and the reagent needle are both movable up and down relative to the second moving arm, the first moving arm is slidably connected to a rear inner side wall of the housing by a sliding plate so as to move the first moving arm in a transverse direction of the rear inner side wall, thereby moving the sample needle and the reagent needle between the sample site and the reagent site and the detection system.
13. The fully automated coagulation analyzer of claim 12, further comprising a cleaning station for cleaning the sample needle and the reagent needle, a cleaning fluid line external to the housing entering the housing through a line port on the housing for connection with the sample needle and the reagent needle to clean the sample needle and the reagent needle at the cleaning station.
14. The fully automated coagulation analyzer of claim 12, wherein the reagent needle is provided with a pre-heating module to pre-heat the reagent needle.
15. The fully automatic coagulation analyzer according to claim 1 or 2, wherein the waste cup housing mechanism comprises a waste cup housing box provided at a position of the lower portion of the housing near the detection system by a housing box drawer.
16. The fully automated coagulation analyzer of claim 1 or 2, further comprising a wireless communication module to communicate with other devices for detection result output.
17. The automatic coagulation analyzer according to claim 1 or 2, wherein the housing upper portion is provided with a cover capable of opening an inner space of the housing.
CN201811344152.8A 2018-11-13 2018-11-13 Full-automatic blood coagulation analyzer Active CN109283351B (en)

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CN113567688A (en) * 2021-07-07 2021-10-29 北京九强生物技术股份有限公司 Blood coagulation analyzer

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