CN217505892U - Blood coagulation analyzer - Google Patents

Abstract

The utility model is suitable for the field of medical equipment, and discloses a blood coagulation analyzer, which comprises a reaction container providing device, a sample detection device, a sample separate injection device, a reagent disc and a reagent separate injection device, wherein the reaction container providing device is used for providing a reaction container; the sample dispensing device comprises a sample needle and a first driving device for driving the sample needle to move; the reagent tray is used for bearing reagent containers; the reagent dispensing device comprises a reagent needle and a second driving device for driving the reagent needle to move, wherein the reagent needle is used for sucking reagent from a reagent container on the reagent disk and dispensing at least part of the sucked reagent into a reaction container; the sample detection device is used for detecting a sample made of a sample and a reagent in a reaction container. The utility model discloses reduce blood coagulation analyzer's part quantity, reduced blood coagulation analyzer's volume, occupation space and cost.

Description

Blood coagulation analyzer

Technical Field

The utility model relates to the field of medical equipment, especially, relate to a blood coagulation analyzer.

Background

The related art provides a blood coagulation analyzer, which includes two reagent disks, a reagent container transfer device, two reagent dispensing devices, two sample dispensing devices, and three reaction container transfer devices, wherein one reagent disk is used for a user to load and unload reagent containers, the other reagent disk is used for the reagent dispensing device to suck reagents, and the reagent container transfer device is used for transferring reagent containers between the two reagent disks. Each reagent dispensing device comprises one or two reagent needles, wherein one reagent dispensing device is used for sucking and dispensing the trigger reagent, and the other reagent dispensing device is used for sucking and dispensing the mixed reagent. Each sample dispensing device comprises a sample needle, wherein the sample needle of one sample dispensing device is used for sucking and dispensing a sample, and the sample needle of the other sample dispensing device is used for sucking and dispensing a diluent. Each reaction vessel transfer device comprises a holding member for holding a reaction vessel. The blood coagulation analyzer provided by the related technology has the following defects in specific application: the number of parts is large, which results in a blood coagulation analyzer that is bulky, space consuming and costly.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a blood coagulation analyzer, it aims at solving among the related art blood coagulation analyzer because component part quantity is too much leads to the technical problem that the instrument is bulky, occupation space is big, with high costs.

In order to achieve the above purpose, the utility model provides a scheme is: a coagulation analyzer, comprising:

a reaction vessel supply device for supplying a reaction vessel;

a sample dispensing device comprising a sample needle for aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into the reaction container, and a first drive device for driving movement of the sample needle;

a reagent tray for carrying reagent containers;

a reagent dispensing device including a reagent needle for sucking a reagent from the reagent vessel on the reagent disk and dispensing at least a part of the sucked reagent into the reaction vessel, and a second driving device for driving the reagent needle to move;

a sample detection device for detecting a specimen made of a sample and a reagent in the reaction vessel.

The utility model provides a blood coagulation analyzer, quantity through with the sample needle, the quantity of reagent dish, the quantity of reagent needle is all established to one, thereby the part quantity of blood coagulation analyzer has been reduced, the structure of blood coagulation analyzer has been simplified, make blood coagulation analyzer reach to retrench, compact design effect, the volume that has effectively reduced blood coagulation analyzer, occupation space and cost, do benefit to the application demand that satisfies blood coagulation analyzer at the small space occasion and satisfy low-cost blood coagulation analyzer's application demand.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a schematic top view of a coagulation analyzer according to an embodiment of the present invention;

fig. 2 is a schematic top view of a coagulation analyzer according to an embodiment of the present invention.

The reference numbers illustrate: 100. a reaction vessel supply device; 200. a sample detection device; 300. a sample dispensing device; 400. a reagent tray; 500. a reagent dispensing device; 600. a transfer device; 700. a recovery device; 800. a sample introduction device; 810. a sample suction channel; 820. a conveyance device; 821. a delivery channel; 822. a first track transfer conveying device; 823. a second track transfer conveyor; 830. a loading table; 840. unloading the platform; 850. caching a channel; 860. loading and unloading platform; 861. a storage channel; 900. a frame; 910. a first side portion; 920. a second side portion; 930. a third side portion; 940. a fourth side portion; 1000. and identifying the device.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without making creative efforts belong to the protection scope of the present invention.

It should be noted that all the directional indicators (such as upper, lower, left, right, front, and rear … …) in the embodiments of the present invention are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture, and if the specific posture is changed, the directional indicator is changed accordingly.

It will also be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.

In addition, the descriptions related to "first", "second", etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicit ly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.

The first embodiment is as follows:

as shown in fig. 1, a coagulation analyzer according to a first embodiment of the present invention includes a reaction container supplying device 100, a sample detecting device 200, a sample dispensing device 300, a reagent disk 400, and a reagent dispensing device 500. The reaction vessel supply apparatus 100 is used to supply a reaction vessel. The sample detection apparatus 200 is used for detecting a sample in a reaction vessel. The sample dispensing device 300 is also called a sample dispensing device, and is used for sucking a sample from a sample container and dispensing at least a part of the sucked sample into a reaction container. The reagent tray 400 is used to carry reagent containers. The reagent dispensing device 500 is also called a reagent dispensing device, and is used to aspirate a reagent from a reagent container on the reagent disk 400 and dispense at least a part of the aspirated reagent into a reaction container. In the embodiment, the number of the sample dispensing devices 300, the number of the reagent disks 400 and the number of the reagent dispensing devices 500 are set to be one, so that the number of components of the coagulation analyzer is reduced, the structure of the coagulation analyzer is simplified, the size, the occupied space and the cost of the coagulation analyzer are effectively reduced, and the application requirement of the coagulation analyzer in a small space occasion and the requirement of a low-cost coagulation analyzer are favorably met.

In one embodiment, the sample dispensing device 300 includes a sample needle for aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container, and a first driving device for driving the sample needle to move. In the embodiment, the number of the sample needles is one, so that the structure related to sample separate injection in the blood coagulation analyzer is simplified. The first driving device is used for driving the sample needle to perform spatial movement so as to move the sample needle to different stations.

As an embodiment, the reagent dispensing device 500 includes one reagent needle for sucking a reagent from a reagent container on the reagent disk 400 and dispensing at least a part of the sucked reagent into a reaction container, and a second driving device for driving the reagent needle to move. In this embodiment, the number of the reagent needles is one, so that the structure related to reagent separate injection in the blood coagulation analyzer is simplified. The second driving device is used for driving the reagent needle to perform spatial movement so as to enable the reagent needle to move to different stations.

In one embodiment, the sample testing items performed by the blood coagulation analyzer include diluted sample testing items requiring dilution and non-diluted sample testing items not requiring dilution, according to whether dilution is required or not. According to different types of the added reagents, sample detection items executed by the coagulation analyzer comprise a double-reagent detection item and a single-reagent detection item, wherein the double-reagent detection item needs to respectively inject a trigger reagent and a mixed reagent into a reaction container loaded with a sample; the single reagent detection item requires dispensing a trigger reagent into a reaction vessel loaded with a sample, and does not require dispensing a mixed reagent. The sample of the double-reagent test item may be a diluted sample test item or a non-diluted sample test item, that is, a sample of the double-reagent test item, and may be made of a sample, a mixed reagent, or a trigger reagent, or may be made of a sample, a mixed reagent, a trigger reagent, or a diluent. The single reagent test item may be a diluted sample test item or a non-diluted sample test item, that is, a sample of the single reagent test item, and may be made of a sample and a trigger reagent, or may be made of a sample, a trigger reagent, and a diluent. Of course, in a particular application, the sample testing items that can be performed by the coagulation analyzer are not limited thereto, and for example, as an alternative embodiment, the sample testing items that can be performed by the coagulation analyzer may include only one of diluted sample testing items and non-diluted sample testing items, or the sample testing items that can be performed by the coagulation analyzer may include only one of dual reagent testing items and single reagent testing items.

As an embodiment, sample testing items that can be performed by the coagulation analyzer include, but are not limited to: plasma Prothrombin (PT), activated partial thromboplastin (APTT), Fibrinogen (FIB), thrombin (TT), and antithrombin III (AT III). The activated partial thromboplastin project (APTT) is a double-reagent detection project, and mixed reagents are required to be added in the incubation process to prepare a sample.

In one embodiment, the sample needle is further used to aspirate a diluent from a reagent container on the reagent disk 400 and dispense at least a portion of the aspirated diluent into a reaction container. In the present embodiment, the number of the sample needles is one, and the sample needles are used for sucking and dispensing a sample as well as for sucking and dispensing a diluent. The sample and the diluent are absorbed and distributed in a time-sharing multiplexing mode through one sample needle, and an independent absorption and distribution device does not need to be arranged for the diluent independently, so that the structure of the sample analyzer is effectively simplified, and the cost and the volume of the sample analyzer are reduced.

As an embodiment, at least one of the first driving device and the second driving device comprises a horizontal rotation mechanism, that is, the motion output by at least one of the first driving device and the second driving device is a horizontal rotation motion, which is beneficial to prevent the size of the coagulation analyzer in a single linear direction from being too large.

As an embodiment, at least one of the first driving device and the second driving device includes a horizontal linear motion mechanism, that is, the motion output by at least one of the first driving device and the second driving device is a horizontal linear motion, and the driving structure of the horizontal linear motion is simple, easy to implement and convenient to maintain.

As an embodiment, one of the first driving device and the second driving device includes a horizontal rotation mechanism, and the other includes a horizontal linear motion mechanism. In the present embodiment, the movement patterns of the sample needle and the reagent needle are different, which is advantageous for arranging the sample needle and the reagent needle in a limited space, and can prevent the movement of the sample needle and the reagent needle from interfering with each other. Of course, in a specific application, the arrangement of the first driving device and the second driving device is not limited to this, for example, as an alternative embodiment, the first driving device and the second driving device both include a horizontal rotation mechanism; or, as another alternative embodiment, both the first drive means and the second drive means comprise a horizontal linear motion mechanism.

As an embodiment, the first driving device comprises a first horizontal rotation mechanism and a first lifting mechanism, the first horizontal rotation mechanism is used for driving the sample needle to move horizontally, and the first lifting mechanism is used for driving the sample needle to move up and down. The first horizontal rotating mechanism is mainly used for driving the sample needle to move to different stations, such as a standby station, a sample sucking station, a sample adding station and a sample needle cleaning station. The arrangement of the first lifting mechanism can enable the sample needle to descend to a height position suitable for sample sucking, sample adding and cleaning, and the sample needle cannot collide with other components when the first horizontal rotating mechanism drives the sample needle to move.

As an embodiment, the first horizontal rotation mechanism is used for driving the sample needle to rotate to the following stations: standby position, dilution liquid level, sample sucking position, sample needle cleaning position, sample adding position and dilution liquid level.

In one embodiment, the sample needle is mounted on a first horizontal rotation mechanism, and the first horizontal rotation mechanism is mounted on a first elevation mechanism. The movement process of the sample sucking and sample adding of the sample needle is as follows: the first horizontal rotating mechanism drives the sample needle to move to the position above the sample container at the sample sucking position, the first lifting mechanism drives the sample needle to descend and extend into the sample container, the sample needle sucks a sample from the sample container, after the sample sucking is finished, the first lifting mechanism drives the sample needle to ascend to the position above the sample container, the first horizontal rotating mechanism drives the sample needle to move to the position above the reaction container at the sample adding position, the first lifting mechanism drives the sample needle to descend and extend into the reaction container, the sample needle discharges the sample into the reaction container, and after the sample adding is finished, the first lifting mechanism drives the sample needle to ascend to the position above the reaction container. In this embodiment, the first lifting mechanism drives the sample needle to lift up and down by lifting up and down the first horizontal rotation mechanism, and of course, the mutual relationship between the first lifting mechanism and the first horizontal rotation mechanism is not limited to this, for example, as an alternative embodiment, the sample needle is mounted on the first lifting mechanism, and the first horizontal rotation mechanism is mounted on the first horizontal rotation mechanism, and in this alternative embodiment, the first horizontal rotation mechanism drives the sample needle to rotate horizontally by rotating horizontally by the first lifting mechanism.

As an embodiment, the first horizontal rotation mechanism includes a first swing arm, a first motor for driving the first swing arm to rotate, and a first transmission mechanism drivingly connected between the first motor and the first swing arm, and the sample needle is mounted on the first swing arm.

In one embodiment, the sample dispensing apparatus 300 further includes a sample suction line and a first suction and discharge power component, the sample suction line is connected to the sample needle and the first suction and discharge power component, and the first suction and discharge power component is configured to provide a driving force for the sample needle to suck and discharge fluid. The first suction and discharge power component may be a syringe or a pump.

In one embodiment, the reagent disk 400 is a circular rotatable structure, and the reagent disk 400 has a plurality of receiving slots distributed along the circumference for receiving reagent containers. By rotating the reagent disk 400, different accommodating grooves can be rotated to the reagent sucking position and the loading and unloading position.

In one embodiment, the second driving device includes a first horizontal linear motion mechanism for driving the reagent needle to move horizontally and linearly, and a second lifting mechanism for driving the reagent needle to move up and down. The first horizontal linear motion mechanism is mainly used for driving the sample needle to move to different stations, such as a standby station, a reagent sucking station, a reagent adding station, a reagent needle cleaning station and the like. The reagent needle can descend to the appropriate height position of inhaling reagent, adding reagent, washing for the setting of second elevating system, and can make first horizontal linear motion mechanism drive reagent needle when moving reagent needle can not bump with other parts. The second driving device is arranged in a linear mode and erected above the reagent tray 400, so that the space layout is more compact, the area size of the blood coagulation analyzer can be compressed to be as small as possible, and the size requirement of the whole device is met.

As an embodiment, the first horizontal linear mechanism is used for driving the reagent needle to move horizontally and linearly to the following stations: a standby position, a reagent sucking position, a reagent needle cleaning position and a reagent adding position.

In one embodiment, the reagent needle is mounted on a second elevating mechanism, and the second elevating mechanism is mounted on the first horizontal linear motion mechanism. The motion process of reagent needle sucking and reagent adding is as follows: the reagent needle is driven by the first horizontal linear motion mechanism to move to the position above a reagent container at a reagent sucking position, the second lifting mechanism drives the reagent needle to descend and extend into the reagent container, the reagent needle sucks reagent from the reagent container, after reagent sucking is completed, the second lifting mechanism drives the reagent needle to ascend to the position above the reagent container, the first horizontal linear motion mechanism drives the reagent needle to move to the position above a reaction container at a reagent adding position, the second lifting mechanism drives the reagent needle to descend and extend into the reaction container, the reagent needle discharges the reagent into the reaction container, and after reagent adding is completed, the second lifting mechanism drives the reagent needle to ascend to the position above the reaction container.

As an implementation manner, the first horizontal linear motion mechanism includes a first guide rail, a first slider in sliding fit with the first guide rail, a second motor for driving the first slider to move along the first guide rail, and a second transmission mechanism connected between the second motor and the first slider in a transmission manner. The first horizontal linear motion mechanism adopts a beam structure, and the sample needle reciprocates above the reagent disk 400, so that the occupied area of the blood coagulation analyzer is reduced. Of course, in a specific application, the arrangement manner of the first horizontal linear motion mechanism is not limited to this, for example, as an alternative embodiment, the first horizontal linear motion mechanism may also adopt an air cylinder or a hydraulic cylinder.

In one embodiment, the reagent dispensing device 500 further includes a reagent sucking pipeline and a second sucking and discharging power component, the reagent sucking pipeline is connected to the reagent needle and the second sucking and discharging power component, and the second sucking and discharging power component is configured to provide driving force for the reagent needle sucking and discharging fluid. The second suction and discharge power component can be a syringe or a pump.

In one embodiment, the reagent tray 400 is used for loading, unloading, and storing reagent containers. The reagent tray 400 is provided with a refrigerating part for refrigerating the reagent container, so that the reagent in the reagent tray 400 can be kept at a lower temperature, thereby being beneficial to ensuring the validity period of the reagent. In a specific application, a user or a robot may place a reagent container containing a reagent in the reagent tray 400, thereby implementing loading of the reagent container. The reagent containers are refrigerated in the reagent tray 400, i.e. storage of the reagent containers is achieved. The reagent disk 400 can rotate different reagent containers to a reagent sucking position by rotation, and then the reagent dispensing apparatus 500 can suck corresponding reagents from the reagent containers in the reagent disk 400, thereby sucking the reagents. After the reagent in the reagent container is used, the user or the robot may take the reagent container out of the reagent tray 400, thereby achieving the unloading of the reagent container.

As an embodiment, the reagent dispensing device 500 further comprises a heating component for heating the reagent needle to ensure that the reagent can be heated to a preset temperature before being added to the reaction vessel. Since the reagent disk 400 is used to guarantee reagent expiration, the operating temperature is low, for example, below 16 ℃; in order to ensure that the coagulation reaction process is complete and accurate test results are obtained, the reagents need to be heated to about 37 ℃ before being added to the reaction vessel. In this embodiment, the reagent dispensing device 500 is provided with a heating element, which can rapidly heat the reagent in a short time after the reagent is sucked by the reagent needle, thereby improving the testing speed of the blood coagulation analyzer.

As one embodiment, the sample test apparatus 200 is used for testing a sample made of a sample and a reagent in a reaction vessel.

In one embodiment, the sample testing device 200 includes at least one light emitting unit for emitting light toward each reaction vessel loaded with the sample, and a plurality of light receiving units for receiving light information generated by the light transmitted or reflected or scattered through the sample.

As an embodiment, the blood coagulation analyzer further comprises a transferring device 600, wherein the transferring device 600 comprises a holding member for holding the reaction vessel and a third driving device for driving the holding member to move to transfer the reaction vessel. In this embodiment, the whole blood coagulation analyzer is provided with only one holding member for transferring the reaction vessel, and the number of parts is greatly reduced.

As an embodiment, the blood coagulation analyzer further comprises an incubation device for incubating the sample in the reaction vessel and a recovery device 700; the recycling device 700 is used for recycling the reaction vessel; the third driving means is for driving the gripping member to transfer the reaction vessel from the reaction vessel providing apparatus 100 to the incubation apparatus, and for driving the gripping member to transfer the reaction vessel from the incubation apparatus to the reagent adding station, for driving the gripping member to transfer the reaction vessel from the reagent adding station to the sample testing apparatus 200, and for driving the gripping member to transfer the reaction vessel from the sample testing apparatus 200 to the recovery apparatus 700. In the double-reagent detection item, the third driving device firstly transfers the reaction container loaded with the sample or loaded with the sample and the diluent to the incubation device for the first stage of incubation; after the first-stage incubation is finished, the third driving device transfers the reaction container to a reagent adding station to add a mixed reagent; then the third driving device transfers the reaction container to the incubation device for the second stage incubation; after the second stage incubation is completed, the third driving device transfers the reaction container to a reagent adding station to add the trigger reagent and mix the trigger reagent uniformly, and the third driving device transfers the reaction container to the sample detection device 200 to perform sample detection; after the sample detection is completed, the third driving device transfers the reaction container to the recycling device 700 for recycling. In the single-reagent detection item, the third driving device firstly transfers the reaction container loaded with the sample or the sample and the diluent to the incubation device for incubation; after the incubation is finished, the third driving device transfers the reaction container to a reagent adding station to add a trigger reagent and uniformly mix the trigger reagent; then the third driving device transfers the reaction container to the sample detection device 200 for sample detection; after the sample detection is completed, the third driving device transfers the reaction container to the recycling device 700 for recycling.

As an embodiment, the third driving device is a device for driving the clamping member to perform a three-dimensional linear motion. The clamping component comprises a clamping jaw and a clamping driving mechanism for driving the clamping jaw to open and close.

As an embodiment, the third driving device includes a second horizontal linear motion mechanism for driving the clamping member to move linearly in the first horizontal direction, a third horizontal linear motion mechanism for driving the clamping member to move linearly in the second horizontal direction, and a third lifting mechanism for driving the clamping member to move up and down. The first horizontal direction and the second horizontal direction are perpendicular to each other. Of course, in a specific application, the arrangement manner of the third driving device is not limited to this, for example, the third driving device may also adopt a combination of a swing arm rotating mechanism and a lifting mechanism to realize three-dimensional motion.

As an implementation manner, the second horizontal linear motion mechanism includes a second guide rail, a second slider in sliding fit with the second guide rail, a third motor for driving the second slider to move along the second guide rail, and a third transmission mechanism in transmission connection between the third motor and the second slider. Of course, in a specific application, the arrangement manner of the second horizontal linear motion mechanism is not limited to this, for example, as an alternative embodiment, the second horizontal linear motion mechanism may also adopt an air cylinder or a hydraulic cylinder.

As an embodiment, the incubation device is integrated with the sample detection device 200 to form an incubation detection device, the incubation detection device includes a fixing frame, a heating device, at least one illumination component and a plurality of light receiving components, a plurality of receiving holes are formed on the fixing frame, each receiving hole is used for receiving one reaction container, one part of the receiving holes are used for carrying the reaction containers for incubation, and the other part of the receiving holes are used for carrying the reaction containers for optical detection. The heating means is used to heat the reaction vessel in the receiving well to a preset temperature (e.g., 37 ℃. + -. 0.5 ℃). The illumination component is used for emitting light to the reaction container of the detection hole (the containing hole used for bearing the reaction container to detect the sample), and the light receiving component is used for receiving light information generated after the light is transmitted or reflected or scattered by the sample in the reaction container. In the embodiment, the incubation device and the sample detection device 200 are integrated, so that on one hand, the centralized arrangement of the heating device can be facilitated, and on the other hand, the moving distance from the incubation position to the detection position after the incubation of the reaction container can be reduced, thereby being beneficial to improving the operating efficiency of the blood coagulation analyzer; in yet another aspect, it may be advantageous to reduce the overall size of the incubation device and the sample testing device 200, as well as reduce the number of components.

As an embodiment, the recycling device 700 is disposed close to the sample testing device 200, so that the moving distance from the testing position to the recycling position after the reaction container is tested can be reduced, thereby improving the operating efficiency of the blood coagulation analyzer. The recovery device 700 includes a recovery port and a recovery box disposed below the recovery port.

As an embodiment, the blood coagulation analyzer further comprises a sample introduction device 800, the sample introduction device 800 comprises a sample suction channel 810 and a transport device 820, the sample suction channel 810 is used for moving a sample rack carrying sample containers therethrough, and a sample needle is used for sucking a sample from the sample container in the sample suction channel 810; the transport device 820 is used to transport the sample rack to the pipetting channel 810 and to remove the sample rack from the pipetting channel 810. The sample sucking channel 810 is provided with a sample sucking position, and the sample containers in the sample rack can be moved to the sample sucking position one by one in a progressive mode to be sucked by the sample needle.

As an embodiment, the sample introduction device 800 further comprises a loading station 830, an unloading station 840 and a buffer channel 850, wherein the loading station 830 is used for loading a sample rack loaded with sample containers and sample containers loaded with samples, the unloading station 840 is used for unloading the sample rack, and the buffer channel 850 is used for buffering the sample rack. The transporter 820 is used for transferring sample racks among the loading station 830, the sample suction passage 810, the buffer passage 850, and the unloading station 840. In a specific application, the sample rack to be tested can be placed on the loading platform 830 by an operator or an operating robot, so as to realize the loading of the sample rack. The detected sample rack can be taken away from the unloading station 840 by an operator or an operating robot to achieve unloading of the sample rack.

In one embodiment, the buffer channel 850 is used to buffer the sample rack after the sample suction is completed to wait for confirmation of whether the retest is required. The conveying device 820 is used for transferring the sample rack from the loading platform 830 to the sample sucking channel 810 for sample sucking, and then transferring the sample rack after sample sucking from the sample sucking channel 810 to the buffer channel 850 for buffering; if the sample in the sample rack needs to be retested, the conveying device 820 transfers the sample rack from the buffer channel 850 to the sample sucking channel 810 for sample reabsorption; if none of the samples in the sample rack require retesting, the transport 820 transfers the sample rack from the buffer tunnel 850 to the unloading station 840.

As an embodiment, the transporting device 820 includes a transporting passage 821 and a first orbital transfer device 822, the transporting passage 821 is used for transporting the sample rack from the loading station 830 to the sample sucking passage 810, and the first orbital transfer device 822 is used for transferring the sample rack among the sample sucking passage 810, the buffer passage 850 and the unloading station 840. The transportation channel 821 and the sample suction channel 810 may be integrally provided or may be separately provided.

As an embodiment, the transporting device 820 further includes a driving unit for driving the sample rack to move in the transportation channel 821 and the sample sucking channel 810. The driving part can drive the sample rack to move from the bottom of the sample rack and can also push the sample rack to move from the side of the sample rack.

As an embodiment, the loading station 830, the buffer passage 850, the first orbital transfer device 822, and the unloading station 840 are sequentially arranged along a first horizontal direction (i.e., the X-axis direction); the transfer passage 821 is provided between the loading stage 830 and the reagent disk 400 in the second horizontal direction (i.e., the Y-axis direction); the sample sucking channel 810 is arranged between the buffer channel 850 and the sample dispensing device 300 along the second horizontal direction; the first horizontal direction and the second horizontal direction are perpendicular to each other. The sample rack moves in the transport path 821 and the suction path 810 in the X-axis direction. The first orbital transfer conveyor 822 includes an orbital transfer vehicle for carrying the sample rack, an orbital transfer drive member for driving the orbital transfer vehicle to move in the Y-axis direction, and a transfer member. The transfer means is used to transfer sample racks between the rail car and the sample intake tunnel 810, to transfer sample racks between the rail car and the buffer tunnel 850, and to transfer sample racks between the rail car and the unloading station 840.

In one embodiment, the blood coagulation analyzer further includes a rack 900, and the reaction container supplying device 100, the sample dispensing device 300, the reagent disk 400, the reagent dispensing device 500, the sample detecting device 200, and the sample introduction device 800 are all provided on the rack 900. The rack 900 is the primary support structure for the sample analyzer, and the rack 900 may be supported on the floor or on a countertop.

In one embodiment, the rack 900 has a first side 910, a second side 920, a third side 930, and a fourth side 940, which are adjacent to each other in sequence, the first side 910 is disposed opposite to the third side 930 with a gap, and the second side 920 is disposed opposite to the fourth side 940 with a gap; the sample introduction device 800 is disposed along the first side portion 910, and the reaction vessel supply device 100 is disposed along the second side portion 920. In this embodiment, the sample injection device 800 and the reaction vessel providing device 100 are respectively disposed along two adjacent sides of the rack 900, so that, on one hand, the sample dispensing device 300 can move to the reaction vessel providing device 100 for sample dispensing in a short stroke after the sample is sucked from the sample injection device 800, which is beneficial to improving the structural compactness of the blood coagulation analyzer; on the other hand, the loading operation surface of the sample rack is closer to the loading surface of the reaction container, so that the operation of an operator is facilitated.

In one embodiment, the reagent disk 400 is disposed near the third side 930 and the fourth side 940, the sample testing device 200 is disposed between the second side 920 and the reagent disk 400 along the direction from the second side 920 to the fourth side 940, and the sample injection device 800, the sample dispensing device 300, and the sample testing device 200 are sequentially disposed along the direction from the first side 910 to the third side 930. By adopting the layout mode, the structure of the blood coagulation analyzer can be compact.

In one embodiment, the loading station 830, the buffer passage 850, the first orbital transfer device 822, and the unloading station 840 are sequentially disposed along the first side portion 910 from the fourth side portion 940 toward the third side portion 930, that is, the loading station 830, the buffer passage 850, the first orbital transfer device 822, and the unloading station 840 are sequentially disposed along the X-axis direction.

In one embodiment, the first side 910 is a front side of the coagulation analyzer, the second side 920 is a left side of the coagulation analyzer, the third side 930 is a rear side of the coagulation analyzer, and the fourth side 940 is a right side of the coagulation analyzer.

As an embodiment, the coagulation analyzer further includes a controller for controlling and operating the reaction vessel supply device 100, the sample testing device 200, the sample dispensing device 300, the reagent disk 400, and the reagent dispensing device 500, thereby facilitating the automation of the coagulation analyzer.

As an embodiment, the sample introduction device 800 further includes an identification device 1000, the identification device 1000 is used for identifying the sample container in the sample rack, and the controller obtains at least the related information of the sample in the sample container according to the feedback information of the identification device 1000. The sample needle is used for sucking the identified sample container.

In one embodiment, the recognition device 1000 is disposed between the loading platform 830 and the buffer passage 850 along the X-axis direction.

In one embodiment, the identification device 1000 is a scanner, such as a barcode scanner or a two-dimensional code scanner. Of course, in specific applications, of course, as an alternative embodiment, the identification device 1000 may also be a visual identification device 1000, such as a CCD camera (also called a CCD image sensor), the english term of CCD is: a Charge coupled Device.

As an embodiment, the present embodiment can provide a compact and compact fully automatic coagulation analyzer for coagulation detection in a space as small as possible. In a fully automatic blood coagulation analyzer, the core of realizing automation of a measurement process is to decompose a complex measurement process into continuous measurement cycles which can be repeatedly executed, so that each component of the analyzer can complete all actions required by measurement in each measurement cycle, and then different measurement processes are realized through the combination of different measurement cycles.

As an embodiment, the working principle of the blood coagulation analyzer provided in this embodiment is as follows:

(1) the whole layout is designed based on a reference surface, and all instrument composition units are arranged on the space of the reference surface, so that the space reference is uniform, and the coordinate debugging is facilitated. In the embodiment, a simplified structural design is adopted to control the size and cost of the whole machine. The sample dispensing device 300 and the reagent dispensing device 500 are compactly arranged around the circular reagent disk 400, using a sample needle of a circular rotary structure and a reagent needle of a horizontal linear motion, respectively. Only at the rear of the apparatus is a reaction vessel transfer device 600 supporting three-dimensional movement arranged in the horizontal direction for transfer and unloading of reaction vessels.

(2) Different unit components are arranged through time and staggered interference points of the movement positions and the mechanical positions are adjusted in space and avoided, so that the interference problem can be solved, and the area and the space of the blood coagulation analyzer are guaranteed to be better and compact.

(3) In order to minimize the occupied area of the blood coagulation analyzer, the sample introduction device 800 is arranged at the front side of the whole machine, an operator places a sample rack with a sample container to be tested in a loading area of the sample introduction device 800, and then starts testing, the sample introduction device 800 conveys the sample rack with the sample container to be tested into a feeding channel (namely a conveying channel 821 and a sample suction channel 810), and the sample rack enters a sample suction position after the barcode scanning function is completed.

(4) The sample dispensing device 300 is positioned behind the sample feeding device 800 and adopts a rotary rocker arm type structure, and a sample needle is arranged at the front part of a rocker arm; on the rotary path of the rotary rocker arm, different working positions such as a sample sucking position, a sample adding position and a cleaning position are arranged, and sample sucking, sample adding, cleaning and the like at different positions in the direction of the circular radian are completed. Specifically, the sample dispensing device 300 first moves to a sample aspirating position, aspirates a centrifuged sample in a sample container, rotationally moves to a sample application position on the reaction container feeder 100, and discharges the aspirated sample to a reaction container newly loaded on the sample application position.

(5) The reaction container providing device 100 is located behind the unloading area of the sample feeding device 800, and the reaction container providing device 100 comprises a storage bin, a reversing mechanism and a cup separating tray. The storage bin is used for containing bulk reaction containers, the reaction containers loaded by operators are picked one by one and conveyed to the reversing mechanism, the reversing function that cup mouths are always vertically upward is achieved by the reaction containers in the reversing mechanism, then the reaction containers are conveyed to the cup distributing disc for caching, and sample adding is waited to be completed.

(6) Above and behind the cup separating tray of the reaction vessel supply device 100, a transfer device 600 for transferring reaction vessels is disposed. The transfer device 600 adopts a two-dimensional beam structure, moves along X, Y direction, and transfers the reaction cup to the sample detection device 200 (i.e. the incubation and sample detection functions are integrated) after grabbing the reaction container filled with the sample from the sample loading position on the cup separating plate.

(7) The sample-testing device 200 has a number of mounting holes, a heating device, a lighting part, and a light-receiving part. The receiving hole is used to receive a reaction vessel transferred by the transfer device 600. The heating device heats the reaction vessel placed in the mounting hole to 37 ℃. + -. 0.5 ℃. The time for which the reaction container is heated in the sample testing device 200 is determined by the time parameters corresponding to different sample testing items. In the sample detection apparatus 200, the reaction container is irradiated with light of multiple wavelengths, the transmitted light or scattered light thereof is received by the light receiving means, and a detection signal corresponding to the amount of the received light is output, and the detection signal is sent to the controller for analysis, processing, and display of data. In the blood coagulation analyzer, a sample is analyzed by a different method such as a coagulation method, an immunoturbidimetric method, and a chromogenic substrate method, and light of different wavelengths is irradiated to the reaction container in the sample detection device 200 depending on the detection method.

(8) The reagent disk 400 is located on the right side of the blood coagulation analyzer and has a cooling member. The reagent disk 400 is used for storage, loading, scheduling of reagents and actual information management; meanwhile, the reagent tray 400 stores non-test reagents such as diluent, needle washing solution, and the like, and supports the sample needles and the reagent needles for sample aspiration and routine maintenance. The reagent disk 400 has a disk structure, and different reagent containers required for a test item are dispatched to the liquid suction positions corresponding to the sample dispensing device 300 and the reagent dispensing device 500 by using a rotation mode within the working cycle time.

(9) The sample testing device 200 and the transfer device 600 are disposed at the rear side of the reagent disk 400, and the sample dispensing device 300 and the reaction vessel supply device 100 are disposed at the left side of the reagent disk 400. The sample dispensing device 300 adopts a rotary rocker arm type structure, and the reagent dispensing device 500 adopts linear arrangement, so that the space layout is more compact, the area size of the blood coagulation analyzer can be compressed to be as small as possible, and the size requirement of the whole machine is met.

(10) The test flow comprises the following steps: after dispensing of a sample and dispensing of a reagent are completed in a loaded reaction vessel, a sample is prepared, the reaction vessel is placed in a sample detection apparatus 200, the sample detection apparatus 200 irradiates the sample in the reaction vessel with multi-wavelength light, and the multi-wavelength light is analyzed by a measurement method of a coagulation method, an immunoturbidimetry method, or a chromogenic substrate method to obtain a coagulation reaction curve that changes with time, thereby calculating a coagulation time or other coagulation related performance parameters, and after a result is output, the reaction vessel is discarded.

The second embodiment:

referring to fig. 1 and fig. 2, the difference between the blood coagulation analyzer provided in this embodiment and the first embodiment is mainly that the sample injection device 800 is arranged differently, which is specifically embodied as: in one embodiment, the sample rack is loaded, buffered, and unloaded at the same location, while in this embodiment, the sample rack is loaded, buffered, and unloaded at three different locations.

Specifically, in this embodiment, the sample introduction device 800 is a channel type sample introduction device 800, the sample introduction device 800 includes a sample suction channel 810, a conveying device 820, and a loading and unloading stage 860840, the loading and unloading stage 860840 includes a plurality of storage channels 861, and each storage channel 861 is used for placing a single sample rack. The storage aisles 861 are used to load, buffer, and unload sample racks.

As an embodiment, the transporting device 820 includes a second orbital transfer device 823, and the second orbital transfer device 823 is used for transferring the sample rack between the sample suction passage 810 and the storage passage 861. The plurality of storage aisles 861 are arranged side by side in sequence along a first horizontal direction (i.e., the X-axis direction); the second orbital transfer conveying device 823 is arranged between the sample suction channel 810 and the loading and unloading station 860840 along a second horizontal direction (i.e., the Y-axis direction); the pipette chip 810 is disposed between the reagent disk 400 and the reaction vessel supply unit 100 in the first horizontal direction; the first horizontal direction and the second horizontal direction are perpendicular to each other. In this embodiment, the second orbital transfer conveyor 823 transfers the sample rack from the storage channel 861 to the specimen aspirating channel 810 in the X-axis direction, and the sample rack moves in the specimen aspirating channel 810 in the Y-axis direction.

In one embodiment, the plurality of storage lanes 861 are arranged side by side in this order along the first side portion 910, and the loading and unloading stage 860840, the second orbital transfer device 823, the specimen suction lane 810, the specimen dispensing device 300, and the specimen detection device 200 are arranged in this order along the first side portion 910 in the direction toward the third side portion 930; the reaction container providing device 100 is disposed along the second side 920, the reagent disk 400 is disposed adjacent to the first side 910 and the fourth side 940, and the sample testing device 200 is disposed between the third side 930 and the reagent disk 400 in a direction from the first side 910 to the third side 930.

In this embodiment, the sample injection device 800 is disposed at the left front side of the rack 900, the front portion of the sample injection device 800 is a sample loading and unloading area, and the rear portion is a sample scheduling and sucking area; after an operator puts the sample rack with the sample container to be tested into the loading area of the sample injection device 800, the test is started, the sample injection device 800 conveys the sample rack with the sample container to be tested into the sample suction channel 810, and the sample rack enters the sample suction position after the barcode scanning function is completed. The sample dispensing device 300 is positioned at the lateral rear part of the sample feeding device 800 and adopts a rotary rocker arm type structure, and a sample needle is arranged at the front part of a rocker arm; different working positions such as a sample sucking position, a sample adding position, a cleaning position and the like are arranged on a rotary path of the rotary rocker arm; the sample dispensing device 300 first moves to a sample aspirating position, aspirates a sample in a sample container, rotationally moves to a sample application position on the reaction container supply device 100, and discharges the aspirated sample to a reaction container newly loaded on the sample application position. The reaction cup supply device is positioned behind the loading and unloading area of the sample feeding device 800 and consists of a storage bin, a reversing mechanism and a cup separating disc. A transfer device 600 for reaction containers is disposed above and behind the cup dispensing tray of the reaction container supply device 100. The transfer device 600 adopts a two-dimensional beam structure, moves along the X/Y direction, and transfers the reaction container to the sample detection device 200 after grabbing the reaction container filled with the sample from the sample adding position on the cup separating plate. The reagent disk 400 is disposed at the right front side of the rack 900. The reagent dispensing device 500 reciprocates above the reagent disk 400 in a beam structure to suck and dispense a corresponding reagent. The sample testing device 200 and the transferring device 600 are disposed at the rear side of the reagent disk 400, and the sample dispensing device 300 and the reaction vessel supply device 100 are disposed at the left side of the reagent disk 400.

In addition to the above differences, the other parts of the blood coagulation analyzer provided in this embodiment can be designed according to a corresponding embodiment, and are not described in detail herein.

The above only be the preferred embodiment of the utility model discloses a not consequently restriction the utility model discloses a patent range, all are in the utility model discloses a conceive, utilize the equivalent structure transform of what the content was done in the description and the attached drawing, or direct/indirect application all is included in other relevant technical field the utility model discloses a patent protection within range.

Claims (13)

1. A coagulation analyzer, comprising:

a reaction vessel supply device for supplying a reaction vessel;

a sample dispensing device comprising a sample needle for aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into the reaction container, and a first drive device for driving movement of the sample needle;

a reagent tray for carrying reagent containers;

a reagent dispensing device including a reagent needle for sucking a reagent from the reagent vessel on the reagent disk and dispensing at least a part of the sucked reagent into the reaction vessel, and a second driving device for driving the reagent needle to move;

a sample detection device for detecting a specimen made of a sample and a reagent in the reaction vessel.

2. The coagulation analyzer of claim 1, wherein: one of the first driving device and the second driving device comprises a horizontal rotating mechanism, and the other one comprises a horizontal linear motion mechanism.

3. The coagulation analyzer of claim 2, wherein: the first driving device comprises a first horizontal rotating mechanism and a first lifting mechanism, the first horizontal rotating mechanism is used for driving the sample needle to move horizontally in a rotating manner, and the first lifting mechanism is used for driving the sample needle to move up and down;

the second driving device comprises a first horizontal linear motion mechanism and a second lifting mechanism, the first horizontal linear motion mechanism is used for driving the reagent needle to do horizontal linear motion, and the second lifting mechanism is used for driving the reagent needle to do lifting motion.

4. The coagulation analyzer of any one of claims 1 to 3, wherein: the coagulation analyzer further includes:

an incubation device for incubating a sample within the reaction vessel;

a recovery device for recovering the reaction vessel;

a transfer device comprising a gripping member for gripping said reaction vessel and third drive means for driving said gripping member to transfer said reaction vessel from said reaction vessel supply means to said incubation means and for driving said gripping member to transfer said reaction vessel from said incubation means to a reagent station, for driving said gripping member to transfer said reaction vessel from said reagent station to a sample detection means, and for driving said gripping member to transfer said reaction vessel from said sample detection means to said recovery means.

5. The coagulation analyzer of claim 4, wherein: the third driving device is used for driving the clamping component to perform three-dimensional linear motion; and/or the presence of a gas in the atmosphere,

the incubation device is integrated with the sample detection device.

6. The coagulation analyzer of claim 1, wherein: the blood coagulation analyzer further comprises a sample introduction device, the sample introduction device comprises:

a sample aspiration channel for moving therethrough a sample rack carrying the sample container, the sample needle for aspirating sample from within the sample container in the sample aspiration channel;

a transport device for transporting the sample rack to the pipetting channel and for removing the sample rack from the pipetting channel.

7. The coagulation analyzer of claim 6, wherein: the sample introduction device further comprises a loading platform, an unloading platform and a cache channel, wherein the loading platform is used for loading the sample frame which is loaded with the sample container and is loaded with the sample in the sample container, the unloading platform is used for unloading the sample frame, and the cache channel is used for caching the sample frame;

the conveying device comprises a conveying channel and a first track-changing conveying device, the conveying channel is used for conveying the sample rack from the loading platform to the sample sucking channel, and the first track-changing conveying device is used for transferring the sample rack among the sample sucking channel, the buffer channel and the unloading platform.

8. The coagulation analyzer of claim 7, wherein: the loading table, the cache channel, the first track transfer conveying device and the unloading table are sequentially arranged along a first horizontal direction;

the conveying channel is arranged between the loading platform and the reagent tray along a second horizontal direction;

the sample sucking channel is arranged between the cache channel and the sample dispensing device along the second horizontal direction;

the first horizontal direction and the second horizontal direction are perpendicular to each other.

9. The coagulation analyzer of any one of claims 6-8, wherein: the blood coagulation analyzer also comprises a frame, wherein the reaction container providing device, the sample separate injection device, the reagent disk, the reagent separate injection device, the sample detection device and the sample injection device are all arranged on the frame;

the frame is provided with a first side part, a second side part, a third side part and a fourth side part which are sequentially adjacent, the first side part and the third side part are arranged oppositely at intervals, and the second side part and the fourth side part are arranged oppositely at intervals;

the sample injection device is arranged along the first side part, the reaction container providing device is arranged along the second side part, the reagent disc is arranged close to the third side part and the fourth side part, the sample detection device is arranged between the second side part and the reagent disc along the direction of the second side part towards the fourth side part, and the sample injection device, the sample distribution device and the sample detection device are sequentially arranged along the direction of the first side part towards the third side part.

10. The coagulation analyzer of claim 6, wherein: the sample feeding device further comprises a loading and unloading platform, the loading and unloading platform comprises a plurality of storage channels, and the storage channels are used for placing the sample rack;

the conveying device comprises a second track-changing conveying device which is used for transferring the sample rack between the sample sucking channel and the storing channel.

11. The coagulation analyzer of claim 10, wherein: the plurality of storage channels are sequentially arranged side by side along a first horizontal direction;

the second orbital transfer conveying device is arranged between the sample suction channel and the loading and unloading platform along a second horizontal direction;

the sample sucking channel is arranged between the reagent disc and the reaction container providing device along the first horizontal direction;

the first horizontal direction and the second horizontal direction are perpendicular to each other.

12. The coagulation analyzer of claim 10 or 11, wherein: the blood coagulation analyzer also comprises a frame, wherein the reaction container providing device, the sample dispensing device, the reagent disc, the reagent dispensing device, the sample detecting device and the sample feeding device are all arranged on the frame;

the frame is provided with a first side part, a second side part, a third side part and a fourth side part which are sequentially adjacent, the first side part and the third side part are arranged oppositely at intervals, and the second side part and the fourth side part are arranged oppositely at intervals;

the plurality of storage channels are sequentially arranged side by side along the first side part, and the loading and unloading platform, the second orbital transfer conveying device, the sample sucking channel, the sample dispensing device and the sample detection device are sequentially arranged along the direction of the first side part towards the third side part; the reaction container providing device is disposed along the second side portion, the reagent disk is disposed adjacent to the first side portion and the fourth side portion, and the sample detection device is disposed between the third side portion and the reagent disk in a direction from the first side portion toward the third side portion.

13. The coagulation analyzer of any one of claims 1 to 3, or 6, or 7, or 8, or 10, or 11, wherein: the sample needle is also used for sucking diluent from the reagent containers on the reagent disk and dispensing at least part of the sucked diluent into the reaction containers.

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