CN111257579A - Full-automatic chemiluminescence immunoassay analyzer - Google Patents

Full-automatic chemiluminescence immunoassay analyzer Download PDF

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Publication number
CN111257579A
CN111257579A CN202010207575.6A CN202010207575A CN111257579A CN 111257579 A CN111257579 A CN 111257579A CN 202010207575 A CN202010207575 A CN 202010207575A CN 111257579 A CN111257579 A CN 111257579A
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CN
China
Prior art keywords
module
reagent
cup
lifting
motor
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Pending
Application number
CN202010207575.6A
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Chinese (zh)
Inventor
王斌
何俊杰
陈驰
林浩
颜水强
吴桂林
方章桂
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Xiamen United Medical Instruments Co ltd
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Xiamen United Medical Instruments Co ltd
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Priority to CN202010207575.6A priority Critical patent/CN111257579A/en
Publication of CN111257579A publication Critical patent/CN111257579A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0453—Multiple carousels working in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling

Abstract

The invention discloses a full-automatic chemiluminescence immunoassay analyzer, which comprises a sample feeding frame, a sample frame carrying module, a consumable box carrying module, a sample separate injection module, a reaction cup carrying module, a reagent refrigerator, a reaction disc, a BF disc, a transferring and discarding module, a reagent separate injection module, a cleaning module, an exciting liquid separate injection module and the like, wherein the sample feeding end and the sample discharging end of the sample feeding frame module are connected with the material feeding end and the material discharging end of the sample frame carrying module, the sample separate injection module is connected with the consumable box carrying module, the sample frame carrying module and the reaction disc module, the reaction cup carrying module is connected with the consumable box carrying module and the reaction disc module, and the reagent separate injection module is positioned on one side of the reagent refrigerator module. The modules of the sample feeding rack, the sample rack carrying, the consumable box carrying, the reaction cup carrying and the like are effectively connected, so that the operation is stable and reliable, the modules of reagent dispensing, cleaning, exciting liquid dispensing and the like can automatically complete the procedures of reagent dispensing, reaction cup cleaning, sample detection and the like, and the detection efficiency is high.

Description

Full-automatic chemiluminescence immunoassay analyzer
Technical Field
The invention relates to a medical instrument, in particular to a full-automatic chemiluminescence immunoassay analyzer.
Background
The full-automatic chemiluminescence immunoassay equipment is an instrument for immunological quantitative analysis of a body fluid sample of a patient, can detect a plurality of disease symptoms, has the advantages of high sensitivity, wide linear range, simple instrument and equipment, convenient operation, high analysis speed, automation of experiment completion in the detection process and the like, greatly improves immunoassay efficiency, eliminates artificial subjective errors, stabilizes the quality of rate immunoassay, and is widely applied to the fields of modern clinical immunoassay diagnosis and life science research at present. The existing full-automatic chemiluminescence immunoassay equipment has the defects of low detection efficiency and poor reliability.
Disclosure of Invention
The invention aims to provide a full-automatic chemiluminescence immunoassay analyzer with high detection efficiency and high reliability.
In order to achieve the purpose, the technical solution of the invention is as follows:
the invention relates to a full-automatic chemiluminescence immunoassay analyzer which comprises a main frame, a sample feeding frame module, a sample frame carrying module, a consumable box carrying module, a sample separate injection module, a reaction cup carrying module, a reagent refrigerator module, a reaction disk module, a BF disk module, a uniform mixing module, a transfer discarding module, two reagent separate injection modules, two cleaning modules and an exciting liquid separate injection module, wherein the sample feeding frame module is arranged on the main frame;
the sample injection rack module, the sample rack carrying module, the consumable box carrying module, the sample injection module, the reaction cup carrying module, the reagent refrigerator module, the reaction disk module, the BF disk module, the blending module, the transfer discarding module, the reagent injection module, the two cleaning modules and the exciting liquid injection module are all arranged on the main rack, and the outlet end and the inlet end of the sample injection rack module are connected with the inlet end and the outlet end of the sample rack carrying module; the first station of the sample dispensing module is a consumable box carrying module, the second station of the sample dispensing module is a sample rack carrying module, and the third station of the sample dispensing module is a reaction disc module; the first station of the reaction cup carrying module is a consumable box carrying module, and the second station of the reaction cup carrying module is a reaction disk module; the two reagent separate injection modules are respectively positioned at two sides of the reagent refrigerator module, the first station and the second station of one reagent separate injection module are the reagent refrigerator module and the reaction disk module, and the first station and the second station of the other reagent separate injection module are the reagent refrigerator module and the BF disk module; the three stations of the transfer discarding module are respectively a reaction disk module, a BF disk module and a garbage port arranged on the main rack; the two cleaning modules and the exciting liquid dispensing module are respectively arranged on one side of the BF disk module;
the sample feeding frame module comprises a sample feeding frame, three longitudinal conveying belts, two groups of deflector rod mechanisms and a code scanning mechanism; the three longitudinal conveying belts are arranged in the middle of the sample injection frame and are arranged in parallel along the longitudinal direction, the two groups of deflector rod mechanisms are arranged at the front end and the rear end of the sample injection frame and are arranged in parallel along the transverse direction, and the code scanning mechanism is arranged in the middle of the sample injection frame and is positioned between the two adjacent longitudinal conveying belts; the shifting lever mechanism comprises a shifting lever motor, a shifting lever pulley group, a shifting lever guide rail, a shifting lever fork claw and two shifting lever material channels, wherein the shifting lever motor is installed on the sample injection frame, an output shaft of the shifting lever motor is connected with the shifting lever fork claw through the shifting lever pulley group, the shifting lever fork claw is connected onto the shifting lever guide rail in a sliding manner, the shifting lever guide rail is fixedly installed on the sample injection frame, and the two shifting lever material channels are fixedly installed on the sample injection frame in parallel and are positioned under the shifting lever fork claw, so that the shifting lever fork claw shifts the sample frame back and forth along the shifting lever material;
the sample rack carrying module comprises a carrying rack, two carrying material channels, two carrying conveyer belts, a carrying portal frame, a carrying motor, a carrying belt pulley group and a carrying shifting fork; the two conveying material channels are arranged at the bottom of the conveying rack, the two conveying conveyer belts are arranged at the bottom of the conveying rack and are respectively positioned in the conveying material channels, the conveying portal frame is vertically arranged at the middle part of the conveying rack, the conveying motor is fixedly arranged at the upper part of the conveying portal frame, an output shaft of the conveying motor is connected with the upper end of the conveying shifting fork through a conveying belt wheel group, the lower end of the conveying shifting fork extends to the upper part of the two conveying material channels, the conveying shifting fork can move back and forth between the two conveying material channels, and the feeding ends and the discharging ends of the two conveying material channels are respectively connected with the discharging ends and the feeding ends of the two shifting rod material channels in the shifting rod mechanism;
the consumable box carrying module comprises a box frame, a plurality of box partition plates, a box translation motor, a box translation belt pulley group, a box moving seat, a box translation guide rail, a box lifting motor, a box lifting belt pulley group, a box lifting guide rail and box fork claws; the box moving seat is arranged on the box frame, the box moving seat is connected with the box moving seat through a box moving belt pulley group, the box moving seat is driven to move back and forth, the middle of the box moving seat is connected to a box moving guide rail in a sliding mode, the box moving guide rail is fixed to the middle of the box frame, the box lifting motor is arranged on the box moving seat, the output shaft of the box lifting motor is connected with the box fork claw through a box lifting belt pulley group, the box fork claw is connected to the box lifting guide rail in a sliding mode, and the box lifting guide rail is arranged on the box moving seat in the vertical direction;
the sample separate injection module comprises a separate injection rack, a separate injection horizontal guide rail, a separate injection sliding seat, a separate injection translation motor, a translation belt pulley set, a separate injection swing motor, a swing belt pulley set, a swing shaft, a swing seat, a swing rod, a gun tip grabbing rod, a separate injection lifting motor, a lifting belt pulley set, a lifting lead screw and a separate injection lifting guide rail; the horizontal dispensing guide rail is installed on the horizontal dispensing machine frame in the horizontal direction, the horizontal dispensing translation motor is fixed on the horizontal dispensing machine frame, the output shaft of the horizontal dispensing translation motor is connected with the dispensing sliding seat through the translation belt pulley set, the dispensing sliding seat is connected on the horizontal dispensing guide rail in a sliding mode, the dispensing swing motor is fixed on the dispensing sliding seat, the output shaft of the dispensing swing motor is connected with the upper end of the swing shaft through the swing belt pulley set, a shaft hole in the inner end of the swing seat is sleeved in the middle of the swing shaft and is connected through a groove block in a plugging mode, the swing seat can move up and down along the swing shaft without relative rotation, the swing seat is connected on the dispensing lifting guide rail in a sliding mode, the dispensing lifting guide rail is fixed on the dispensing sliding seat in the vertical direction, the dispensing lifting motor is installed on the dispensing sliding seat, the output shaft of the dispensing lifting motor, the inner end of the swing rod is fixed in the middle of the swing shaft, and the gun point grabbing rod is arranged at the outer end of the swing rod;
the reaction cup carrying module comprises a cup rack, a cup translation motor, a cup translation belt pulley group, a cup moving seat, a cup guide rail, a cup lifting motor, a cup lifting belt pulley group, a cup lifting seat, a cup gripping mechanism and a cup lifting screw rod; the cup lifting mechanism comprises a cup lifting screw rod, a cup translation motor, a cup moving seat, a cup lifting screw rod, a cup clamping mechanism and a cup lifting seat, wherein the cup translation motor is fixed on a cup frame;
the reagent refrigerator module comprises a refrigerating tank, a turntable motor, a turntable belt pulley group, a first rotating gear, a second rotating gear, a plurality of third rotating gears, a turntable gear group, a turntable shaft, a blending motor, a blending belt pulley group, a blending main shaft, a plurality of blending cups and a refrigerating component; the rotary disc motor is arranged at the bottom of the refrigeration tank, an output shaft of the rotary disc motor is connected with the rotary disc shaft through a rotary disc belt wheel set, the rotary disc shaft is rotatably arranged at the bottom of the refrigeration tank and is connected with the rotary disc through a rotary disc gear set, and the center of the rotary disc is movably sleeved at the upper part of the blending main shaft; the blending motor is arranged at the bottom of the refrigeration tank, an output shaft of the blending motor is connected with a blending main shaft through a blending belt pulley group, the blending main shaft is rotatably arranged at the bottom of the refrigeration tank, the upper part of the blending main shaft penetrates through the turntable and then is fixedly sleeved in the center of the first rotating gear, the first rotating gear is meshed with the second rotating gear, the second rotating gear is meshed with a plurality of third rotating gears, the plurality of third rotating gears are mutually meshed, the plurality of third rotating gears are respectively fixedly sleeved on rotating shafts of the plurality of blending cups, the plurality of blending cups are respectively sleeved in a plurality of through holes on the periphery of the turntable, and the plurality of blending cups are uniformly arranged around the center of the turntable; the refrigeration component is arranged on the bottom surface of the refrigeration tank.
The reaction disc module comprises a reaction disc rack, a reaction disc motor, a reaction disc belt pulley group, a reaction disc rotating shaft, a reaction disc cup unloading mechanism and a reaction disc heating element; the reaction disc heating device comprises a reaction disc motor, a reaction disc cup unloading mechanism, a reaction disc heating element, a reaction disc rotating shaft, a reaction disc cup unloading mechanism and a reaction disc heating element, wherein the reaction disc motor is arranged on a reaction disc frame, an output shaft of the reaction disc motor is connected with the reaction disc rotating shaft through a reaction disc belt pulley group, the reaction disc rotating shaft is rotatably arranged on the reaction disc frame, the center of the reaction disc is fixedly sleeved at the upper end of the reaction disc rotating shaft, the reaction disc cup unloading mechanism is arranged; the reaction disc cup unloading mechanism comprises a fixed rod, two electromagnetic valves and two clamping rods, wherein the outer end of the fixed rod is fixed on the reaction disc rack, the inner end of the fixed rod extends to the top surface of the reaction disc, the two electromagnetic valves are arranged on the inner side of the fixed rod, the two electromagnetic valves of the two clamping rods are arranged oppositely, and the valve rods of the two electromagnetic valves are respectively connected with the clamping rods;
the reagent separate injection module comprises a reagent rack, a reagent lifting motor, a reagent lifting belt pulley group, a reagent lifting lead screw, a reagent lifting guide rail, a reagent lifting seat, a reagent swinging motor, a reagent swinging belt pulley group, a reagent swinging disc, a reagent lifting rod, a reagent needle rod and a suction needle; the reagent lifting motor is arranged at the bottom of the reagent rack, an output shaft of the reagent lifting motor is connected with the lower end of a reagent lifting screw rod through a reagent lifting belt pulley group, the reagent lifting screw rod is rotatably arranged on the reagent rack, the upper part of the reagent lifting screw rod is in threaded connection with a reagent lifting seat, the reagent lifting seat is in sliding connection with a reagent lifting guide rail, and the reagent lifting guide rail is fixedly arranged on the reagent rack along the vertical direction; the reagent swing motor is arranged at the top of the reagent rack, an output shaft of the reagent swing motor is connected with the reagent swing disc through the reagent swing belt pulley group, the lower end of the reagent lifting rod is fixed on the reagent lifting seat, the middle gap of the reagent lifting rod is arranged in the slot in the middle of the reagent swing disc in a penetrating way, the middle of the reagent lifting rod is matched with the slot in the middle of the reagent swing disc by a slot block, the upper end of the reagent lifting rod is vertically connected with the inner end of the reagent needle rod, and the outer end of the reagent needle rod is vertically connected with the suction needle;
the cleaning module comprises a cleaning rack, a cleaning motor, a cleaning screw rod, a cleaning sliding seat, a cleaning needle bracket, more than one cleaning needle and a cleaning guide rail; the cleaning machine is arranged on the cleaning rack, an output shaft of the cleaning machine is connected with the lower end of a cleaning screw rod, the lower part of the cleaning screw rod is rotatably arranged on the cleaning rack, the upper part of the cleaning screw rod is in threaded connection with a cleaning sliding seat, the lower end of a cleaning needle support is fixed on the cleaning sliding seat, the cleaning sliding seat is in sliding connection with a cleaning guide rail, the cleaning guide rail is fixedly arranged on the cleaning rack and is arranged along the vertical direction, and more than one cleaning needles are arranged on the upper part of the cleaning needle support;
the exciting liquid separate injection module comprises an exciting liquid rack, an exciting liquid lifting motor, an exciting liquid belt pulley group, an exciting liquid sliding seat, an exciting liquid bracket, an exciting liquid upper guide rail, two exciting liquid needles, an upper top seat, an upper guide rod, an upper pressure rod, an upper spring, an upper product seat, an exciting liquid lower guide rail, a cam shaft, a top wheel, a lower top seat, a lower guide rod, a lower spring, a lower product seat and a tension spring; the device comprises an excitation liquid lifting motor, an excitation liquid pulley group, an excitation liquid sliding seat, an excitation liquid upper guide rail, two excitation liquid needles, an upper top seat, an upper spring, an upper top seat, an upper guide rod, an upper product seat, an upper pressure rod, an upper spring, an upper pressure rod and an upper product seat, wherein the excitation liquid lifting motor is fixed on an excitation liquid rack; the inner end of the lower top seat is connected to an exciting liquid lower guide rail in a sliding manner, the exciting liquid lower guide rail is fixed on an exciting liquid rack, a lower product seat is movably arranged at the outer end of the lower top seat in a penetrating manner through a lower guide rod, a lower spring is arranged between the lower product seat and the lower top seat, a top wheel is rotatably arranged on the lower top seat and is abutted against a cam, the cam is fixed on a lower belt pulley of an exciting liquid belt pulley set through a cam shaft and is eccentric, and two ends of a tension spring are respectively hung on the lower top seat and the exciting liquid rack;
the exciting liquid belt pulley set comprises an upper belt pulley, a lower belt pulley, a first guide wheel, a second guide wheel, a third guide wheel and a belt, wherein the upper belt pulley and the lower belt pulley are arranged at the upper end and the lower end, the first guide wheel, the second guide wheel and the third guide wheel are sequentially arranged from top to bottom, the two ends of the belt are wound on the upper belt pulley and the lower belt pulley, and the middle part of the belt passes through the space between the first guide wheel and the second guide wheel and then abuts against the inner side of the third guide wheel;
the invention also includes a sample station module mounted on the mainframe.
After the scheme is adopted, the invention has the following advantages:
1. the sample feeding rack module, the sample rack carrying module, the consumable box carrying module, the sample separate injection module and the reaction cup carrying module are effectively connected, so that the operation is stable and reliable.
2. The reagent dispensing module, the cleaning module and the exciting liquid dispensing module can automatically complete the procedures of reagent dispensing, reaction cup cleaning, sample detection and the like, so that the detection efficiency is high.
3. The invention is the equipment which can realize the cooperative work of a plurality of single machines by using an integrated assembly line system to cascade a plurality of tests on the limitation of the detection speed of the system based on the single machine, can uniformly manage and set instruments, uniformly manage samples and detection results, improve the detection efficiency, reduce the labor cost and further reduce the equipment volume. Based on the chemiluminescence technology, the invention is matched with an immunoassay reagent according to the reaction principles of a sandwich method, an indirect method, a capture method, a competition method and the like, and the qualitative or quantitative detection of clinical immunization items is carried out on the serum, the plasma and the urine from a human body through a magnetic particle coated solid phase and an acridinium ester labeled luminophore.
The invention is further described with reference to the following figures and specific embodiments.
Drawings
FIG. 1 is an isometric view of the present invention;
FIG. 2 is a front view of the present invention;
FIG. 3 is a top view of the present invention;
FIG. 4 is a cross-sectional view taken along line A-A of FIG. 2;
FIG. 5 is an isometric view of a sample introduction rack module of the present invention;
FIG. 6 is an isometric view of a specimen rack transport module of the present invention;
FIG. 7 is an isometric view of a consumable cartridge handling module of the present invention;
FIG. 8 is an isometric view of a sample dispensing module of the present invention;
FIG. 9 is an isometric view of a reaction cup handling module of the present invention;
FIG. 10 is an isometric view of a reagent refrigerator module of the present invention;
FIG. 11 is a bottom view of the reagent refrigerator module of the present invention;
FIG. 12 is a cross-sectional view of the reagent refrigerator module of the present invention;
FIG. 13 is an exploded perspective view of the reagent refrigerator module of the present invention;
FIG. 14 is an isometric view of a reaction disk module of the present invention;
FIG. 15 is a cross-sectional view of a reaction disk module of the present invention;
FIG. 16 is an isometric view of the BF disk module of the present invention;
FIG. 17 is an isometric view of a transfer discard module of the present invention;
FIG. 18 is an isometric view of a reagent dispensing module of the present invention;
FIG. 19 is a front view of a reagent dispensing module of the present invention;
FIG. 20 is a side view of a reagent dispensing module of the present invention;
FIG. 21 is an isometric view of a first embodiment of a cleaning module of the present invention;
FIG. 22 is an isometric view of a second embodiment of a cleaning module of the present invention;
FIG. 23 is an isometric view of an excitation liquid dispensing module of the present invention;
FIG. 24 is a front view of an excitation liquid dispensing module according to the present invention;
FIG. 25 is a side view of an excitation liquid dispensing module of the present invention;
FIG. 26 is a schematic structural view of a cup gripping mechanism of the reaction cup carrying module of the present invention, FIG. 1;
FIG. 27 is a schematic structural view of a cup gripping mechanism of the reaction cup carrying module of the present invention, FIG. 2;
FIG. 28 is an exploded view of the cup gripping mechanism of the reaction cup handling module of the present invention;
FIG. 29 is a schematic diagram showing the combination of a cup taking shaft, a pressing block and an elastic member of the cup gripping mechanism in the reaction cup carrying module according to the present invention;
FIG. 30 is a schematic structural view of a cup taking shaft, a pressing block and an elastic member of the cup gripping mechanism in the reaction cup carrying module according to the present invention;
FIG. 31 is an exploded view of a blending module of the present invention;
FIG. 32 is a schematic structural view of a blending module of the present invention;
FIG. 33 is a cross-sectional view of a blending module of the present invention;
FIG. 34 is a schematic view of the use of the blending module of the present invention 1;
FIG. 35 is a schematic representation of the use of the blending module of the present invention 2;
FIG. 36 is a bottom isometric view of the reagent refrigerator module carousel drive assembly of the present invention;
FIG. 37 is a top isometric view of a reagent refrigerator module carousel drive assembly of the present invention.
Detailed Description
As shown in fig. 1-3, the present invention is a full-automatic chemiluminescence immunoassay analyzer, which comprises a main frame 1, a sample introduction frame module 2, a sample frame carrying module 3, a consumable box carrying module 4, a sample dispensing module 5, a reaction cup carrying module 6, a reagent refrigerator module 7, a reaction disk module 8, a BF disk module 9, a transfer discarding module 10, two reagent dispensing modules 20, two cleaning modules 30, an exciting liquid dispensing module 40, a blending module 50, an injector module 60, and a sampling platform module 70.
The sample feeding rack module 2, the sample rack carrying module 3, the consumable box carrying module 4, the sample separate injection module 5, the reaction cup carrying module 6, the reagent refrigerator module 7, the reaction disk module 8, the BF disk module 9, the transfer discarding module 10, the two reagent separate injection modules 20, the two cleaning modules 30, the exciting liquid separate injection module 40, the blending module 50, the injector module 60 and the sampling table module 70 are all arranged on the main rack 1, and the outlet end and the inlet end of the sample feeding rack module 2 are connected with the inlet end and the outlet end of the sample rack carrying module 3; the first station of the sample separate injection module 5 is a consumable box carrying module (taking a gun tip), the second station of the sample separate injection module 5 is a sample rack carrying module 3 (sucking a sample), and the third station of the sample separate injection module 5 is a reaction disc module 8 (putting the sample into a reaction cup); the first station of the reaction cup carrying module 6 is a consumable box carrying module 4 (taking a reaction cup), and the second station of the reaction cup carrying module 6 is a reaction tray module 8 (putting the reaction cup into the reaction tray module 8); the two reagent dispensing modules 20 are respectively positioned at two sides of the reagent refrigerator module 7, the first station and the second station of one reagent dispensing module 20 are the reagent refrigerator module 7 and the reaction disk module 8, and the first station and the second station of the other reagent dispensing module 20 are the reagent refrigerator module 7 and the BF disk module 9; the three stations of the transferring and discarding module 10 are respectively a reaction disk module 8, a BF disk module 9 and a garbage port arranged on the main rack 1; the two cleaning modules 30 and the exciting liquid dispensing module 40 are respectively arranged on one side of the BF disk module 9; the plurality of syringe modules 60 are in communication with the priming solution needles on the priming solution dispensing module 40 via tubing.
As shown in fig. 5, the sample feeding rack module 2 includes a sample feeding rack 21, three longitudinal conveyor belts 22, two groups of shift lever mechanisms 23, and a code scanning mechanism 24; the three longitudinal conveyor belts 22 are arranged in the middle of the sample injection frame 21 and are arranged in parallel along the longitudinal direction, the two groups of deflector rod mechanisms 23 are arranged at the front end and the rear end of the sample injection frame 221 and are arranged in parallel along the transverse direction, and the code scanning mechanism 24 is arranged in the middle of the sample injection frame 21 and is positioned between the two adjacent longitudinal conveyor belts 22. The shift lever mechanism 23 comprises a shift lever motor 231, a shift lever pulley group 232, a shift lever guide rail 233, a shift lever fork claw 234 and two shift lever material channels 235; the driving lever motor 231 is mounted on the sample injection frame 21, an output shaft of the driving lever motor 231 is connected with a driving lever fork claw 234 through a driving lever pulley group 232, the driving lever fork claw 234 is connected on a driving lever guide rail 233 in a sliding manner, the driving lever guide rail 233 is fixedly mounted on the sample injection frame 21, and the two driving lever material channels 235 are fixedly mounted on the sample injection frame 21 in parallel and are located right below the driving lever fork claw 234, so that the driving lever fork claw 234 drives the sample frame 100 (shown in fig. 4) back and forth along the driving lever material channel 235. The three longitudinal conveyor belts 22 are a track for taking out the sample when the sample rack returns, a track for detecting the sample rack, a track for retesting the sample rack, and a track for returning the sample rack after detection.
The working principle of the sample feeding frame module 2 is as follows:
1. the sample rack 100 is transported from the sample introduction unit to the analysis unit by the deflector rod mechanism 23;
2. the three longitudinal conveyor belts 22 realize the transportation of the sample rack from the sample introduction unit to the analysis unit;
3. the code scanning mechanism 24 performs automatic scanning and detection of the sample barcode and the blood vessel barcode.
As shown in fig. 6, the sample rack carrying module 3 includes a carrying rack 31, two carrying material channels 32, two carrying conveyor belts 33, a carrying gantry 34, a carrying motor 35, a carrying pulley set 36, and a carrying fork 37; two transport material ways 32 set up in the bottom of transport frame 21, two transport conveyer belts 33 are installed in the bottom of transport frame 31 and are located transport material way 32 respectively, transport portal frame 34 is installed perpendicularly at the middle part of transport frame 31, transport motor 35 fixed mounting is on the upper portion of transport portal frame 34, the output shaft of transport motor 35 passes through transport belt pulley group 36 and is connected with the upper end of transport shift fork 37, the lower extreme of transport shift fork 37 stretches to the top of two transport material ways 32, transport shift fork 37 can round trip movement between two transport material ways 32, the advance of two transport material ways 32, the discharge end respectively with advance kind this frame module 2 driving lever mechanism two driving lever material ways 235 in the driving lever mechanism 23 go out, the feed end links up.
As shown in fig. 7, the consumable cartridge handling module 4 includes a cartridge rack 41, a plurality of cartridge partitions 42, a cartridge translation motor 43, a cartridge translation pulley set 44, a cartridge moving seat 45, a cartridge translation guide rail 46, a cartridge lifting motor 47, a cartridge lifting pulley set 48, a cartridge lifting guide rail 49, and a cartridge fork 410; the box frame 41 is fixed on the main frame 1, a plurality of box partition plates 42 are arranged in the box frame 41 at intervals along the vertical direction, the box translation motor 43 is installed on the box frame 41, an output shaft of the box translation motor 43 is connected with the box moving seat 45 through a box translation belt pulley group 44, the box moving seat 45 is driven to move back and forth, the middle of the box moving seat 45 is connected to the box translation guide rail 46 in a sliding mode, the box translation guide rail 46 is fixed in the middle of the box frame 41, the box lifting motor 47 is installed on the box moving seat 45, an output shaft of the box lifting motor 47 is connected with the box fork claw 410 through the box lifting belt pulley group 48, the box fork claw 410 is connected to the box lifting guide rail 49 in a sliding mode, and the box lifting guide rail 49 is installed on.
As shown in fig. 8, the sample dispensing module 5 includes a dispensing rack 51, a dispensing horizontal guide rail 52, a dispensing slide 53, a dispensing translation motor 54, a translation belt pulley set 55, a dispensing swing motor 56, a swing belt pulley set 57, a swing shaft 58, a swing seat 59, a swing link 510, a gun tip grab bar 511, a dispensing lifting motor 512, a lifting belt pulley set 513, a lifting screw 514, and a dispensing lifting guide rail 515; the horizontal dispensing guide rail 52 is installed on the dispensing machine frame 51 along the horizontal direction, the dispensing translation motor 54 is fixed on the dispensing machine frame 51, the output shaft of the dispensing translation motor 54 is connected with the dispensing slide carriage 53 through the translation belt pulley set 55, the dispensing slide carriage 53 is in slide connection with the horizontal dispensing guide rail 52, the dispensing swing motor 56 is fixed on the dispensing slide carriage 53, the output shaft of the dispensing swing motor 56 is connected with the upper end of the swing shaft 58 through the swing belt pulley set 57, the shaft hole at the inner end of the swing seat 59 is sleeved in the middle of the swing shaft 58 and is in insert connection through a groove block, so that the swing seat 59 can move up and down along the swing shaft 58 without relative rotation, the swing seat 59 is in slide connection with the dispensing lifting guide rail 515, the dispensing lifting guide rail 515 is fixed on the dispensing slide carriage 53 along the vertical direction, the dispensing lifting motor 512 is installed on the dispensing slide carriage 53, the output shaft of the, the middle part of the lifting screw rod 514 is screwed at the inner end of the swing seat 59 and can drive the swing seat 59 to move up and down, the inner end of the swing rod 510 is fixed at the middle part of the swing shaft 58, and the gun point grabbing rod 511 is arranged at the outer end of the swing rod 510.
It should be noted that the lance grasping rod 511 is similar to the cup grasping mechanism 63 in the reaction cup handling module 6.
The working principle of the sample dispensing module 5 is as follows:
the dispensing translation motor 54 is matched with the translation belt pulley set 55 to realize the horizontal movement of the gun tip grabbing rod 511; the upward and downward movement of the gun tip grabbing rod 511 is realized by the cooperation of a separate injection lifting motor 512, a lifting belt pulley set 513 and a lifting screw rod 514; the dispensing swing motor 56, the swing belt pulley set 57, the swing shaft 58, and the swing of the gun tip grab bar 511 are realized in cooperation.
As shown in fig. 9, the reaction cup carrying module 6 includes a cup frame 61, a cup translation motor 62, a cup gripping mechanism 63, a cup translation pulley group 64, a cup moving seat 65, a cup guide rail 66, a cup lifting motor 67, a cup lifting pulley group 68, a cup lifting seat 69, and a cup lifting screw 610; the cup translation motor 62 is fixed on the cup frame 61, the output shaft of the cup translation motor 62 is connected with the cup moving seat 65 through the cup translation belt pulley group 64, the cup moving seat 65 is connected with the cup guide rail 66 in a sliding mode, the cup guide rail 66 is installed on the cup frame 61, the cup lifting motor 67 is installed on the cup moving seat 65, the output shaft of the cup lifting motor 67 is connected with the upper end of the cup lifting screw rod 610 through the cup lifting belt pulley group 68, the middle portion of the cup lifting screw rod 610 is in screwed connection with the inner end of the cup lifting seat 69, and the upper portion of the cup grabbing mechanism 63 is installed on the outer side of the cup lifting seat 69.
The working principle of the reaction cup carrying module 6 is as follows:
the translation motor 62 realizes the horizontal movement of the cup grabbing mechanism 63 through the cup translation belt pulley group 64; the cup lifting motor 67 is matched with the cup lifting belt pulley set 68 to realize the up-and-down movement of the cup gripping mechanism 63.
As shown in fig. 26 to 30, the cup holding mechanism 63 includes a cup taking shaft 1A for engaging with a lifting mechanism, and the lifting mechanism drives the cup taking shaft 1A to move up and down to drive the cup taking shaft 1A to be inserted into the reaction cup C.
The cup taking shaft 1A is provided with a through groove 11A with a downward opening and two ends penetrating through the bottom, two pressing blocks 2A are matched in the through groove 11A, the two pressing blocks 2A are hinged with the cup taking shaft 1A, and the two pressing blocks 2A can respectively rotate outwards from two ends of the through groove 11A and extend out of the through groove 11A; and an elastic piece 3A for driving the two pressing pieces 2A to rotate outwards is also matched in the through groove 11A. Therefore, after the cup taking shaft 1A is inserted into the reaction cup C, the elastic piece 3A drives the two pressing blocks 2A to rotate outwards, so that the two pressing blocks 2A tightly abut against the inner wall of the reaction cup C to prevent the reaction cup C from separating from the cup taking shaft 1A, the reaction cup C can be stably picked up, the dimensional accuracy requirements on the reaction cup C and the cup taking shaft 1A can be reduced, and the production is facilitated.
Wherein, the lower part of the outer wall of the cup taking shaft 1A can be formed with an inward-contracting oblique guide surface 13A so as to be beneficial to the insertion of the cup taking shaft 1A into the reaction cup. Two briquetting 2A accessible one articulated shaft 12A with get cup axle 1A articulated, articulated shaft 12A is located logical groove 11A and links to each other with getting cup axle 1A2, two briquetting 2A upper ends are equipped with the hinge hole 21 of rotatable cover dress articulated shaft 12A and make two briquetting 2A upper ends articulated with articulated shaft 12A.
The elastic piece 3A can be a compression spring, the inner side surface of the pressing block 2A can be provided with a sunken positioning groove 22, and two ends of the compression spring are respectively embedded in the positioning grooves 22 on the inner side surfaces of the two pressing blocks 2A, so that the compression spring can be prevented from falling off, and the compression spring can apply force to the two pressing blocks 2A to drive the two pressing blocks 2A to rotate outwards. The elastic member 3A is not limited to a compression spring, and a torsion spring may be used, and the two pressing pieces 2A are driven to rotate outwards by the torsion spring.
In order to avoid the two pressing blocks 2A from being clamped by the cup edge of the reaction cup when being inserted into the reaction cup, the lower part of the outer side surface of each pressing block 2A forms a guide inclined surface 23A which is inclined downwards and retracted inwards, and the pressing blocks 2A can be inserted into the reaction cup conveniently through the guide inclined surfaces 23A; in addition, an outward convex cambered surface 24A which protrudes outwards and is connected with the guide inclined surface 23A can be formed in the middle of the outer side surface of the pressing block 2A, and the outer side surface of the pressing block 2A can be tightly abutted against the inner wall of the reaction cup C through the arrangement of the outward convex cambered surface 24A.
The cup grabbing mechanism 63 may further include a mounting seat 4A for connecting with the lifting mechanism, the mounting seat 4A is matched with a mounting shaft 41A capable of moving up and down, the mounting shaft 41A may be movably disposed on a through hole of the mounting seat 4A, the upper portion of the mounting shaft 41A may be matched with a clamping seat 411 movably abutted against the upper surface of the mounting seat 4A, and the mounting shaft 41A is prevented from falling off through the clamping seat 411. The cup taking shaft 1A is fixedly connected with the mounting shaft 41A and is positioned below the mounting shaft 41A, the mounting shaft 41A is sleeved with a buffer spring 42A, and the upper end and the lower end of the buffer spring 42A are respectively abutted against the mounting seat 4A and the cup taking shaft 1A. According to the invention, the mounting seat 4A is driven to move up and down through the lifting mechanism, the mounting seat 4A can drive the cup taking shaft 1A to move up and down, when the cup taking shaft 1A is inserted into the reaction cup C, the mounting shaft 41A capable of moving up and down can move up and down, and the upper end and the lower end of the buffer spring 42A are respectively abutted against the mounting seat 4A and the cup taking shaft 1A, so that the cup taking shaft 1A can move up for a certain distance to play a buffer role, thereby controlling the depth of the cup taking shaft 1A inserted into the reaction cup C, and avoiding the over-tight matching of the cup taking shaft 1A and the reaction cup C caused by the over-deep insertion of the cup taking shaft 1A.
Further, as shown in fig. 26 to 28, a connecting seat 43A and a groove-type photoelectric switch 44A are further fitted on the mounting seat 4A; the connecting seat 43A can be locked with the mounting seat 4A, and the groove-shaped photoelectric switch 44A can be directly fixed on the mounting seat 4A or fixed on the connecting seat 43A; a limiting plate 431A positioned below the mounting seat 4A is arranged on the connecting seat 43A; a movable sleeve 5A is movably sleeved on the cup taking shaft 1A, a baffle 51A which movably abuts against the upper surface of the limiting plate 431A is arranged on the movable sleeve 5A, and the movable sleeve 5A is prevented from falling off from the cup taking shaft 1A through the matching of the baffle 51A and the limiting plate 431A; the movable sleeve 5A is matched with a light barrier 52A, the light barrier 52A moves up and down along with the movable sleeve 5A, and the light barrier 52A can move up and extend into the detection notch 441A of the groove-shaped photoelectric switch 44A, so that after the cup taking shaft 1A is inserted into the reaction cup C, the cup edge of the reaction cup C can push the movable sleeve 5A, the movable sleeve 5A drives the light barrier 52A to move up and extend into the detection notch 441A of the groove-shaped photoelectric switch 44A, the groove-shaped photoelectric switch 44A obtains a signal to confirm that the cup taking shaft 1A is inserted into the reaction cup C, and then the reaction cup C is picked up by the invention, and in the process of driving the reaction cup C to move by the invention, whether the reaction cup C falls off or not in the moving process can also be confirmed by the groove-shaped photoelectric switch 44A.
Further, a guide rod 45A is further matched on the mounting seat 4A, a guide hole 521A of the guide rod 45A is movably sleeved on the light barrier 52A, so that the light barrier 52A can be limited from rotating through the matching of the movable sleeve 5A and the cup taking shaft 1A and the matching of the light barrier 52A and the guide rod 45A, the light barrier 52A can accurately move upwards to extend into the detection notch 441A of the groove-shaped photoelectric switch 44A, in addition, a return spring 46A can be sleeved on the guide rod 45A, the upper end and the lower end of the return spring 46A are respectively abutted against the mounting seat 4A and the light barrier 52A, and the return spring 46A drives the light barrier 52A and the movable sleeve 5A to move downwards to the baffle 51A of the movable sleeve 5A to abut against the limiting plate 431A of the connecting seat 43A.
As shown in fig. 10-13, 36 and 37, the reagent refrigerator module 7 includes a refrigerator tank 71, a turntable motor 72, a turntable pulley set 73, a first rotating gear 74, a second rotating gear 75, a plurality of third rotating gears 76, a turntable gear set 77, a turntable 78, a turntable shaft 79, a kneading motor 791, a kneading pulley set 792, a kneading main shaft 793, a plurality of kneading cups 794 and a refrigerating part 795.
The turntable motor 72 is installed at the bottom of the refrigeration tank 71, an output shaft of the turntable motor 72 is connected with a turntable shaft 79 through a turntable belt pulley set 73, the turntable shaft 79 is rotatably installed at the bottom of the refrigeration tank 71, the turntable shaft 79 is connected with a turntable 78 through a turntable gear set 77 (a pinion 771 of the turntable gear set 77 is fixedly sleeved on the turntable shaft 79, a bull gear 772 of the turntable gear set 77 is fixed on the turntable 78), and the center of the turntable 78 is movably sleeved on the upper part of the blending main shaft 793; the blending motor 791 is installed at the bottom of the refrigeration tank 71, an output shaft of the blending motor 791 is connected with a blending main shaft 793 through a blending pulley group 792, the blending main shaft 793 is rotatably installed at the bottom of the refrigeration tank 71, the upper part of the blending main shaft 793 penetrates through the turntable 78 and then is fixedly sleeved in the center of the first rotating gear 74, the first rotating gear 74 is meshed with the second rotating gear 75, the second rotating gear 75 is meshed with the plurality of third rotating gears 76, the plurality of third rotating gears 76 are mutually meshed, the plurality of third rotating gears 76 are respectively fixedly sleeved on rotating shafts of the plurality of blending cups 794, the plurality of blending cups 794 are respectively sleeved in the plurality of through holes 781 on the periphery of the turntable 78, and the plurality of blending cups 794 are uniformly arranged around the center of the turntable 78; the refrigerating part 795 is installed at the bottom surface of the refrigerating tank 71.
The working principle of the reagent refrigerator module 7 is as follows:
carousel motor 72 drives the carousel 78 through carousel pulley group 73, carousel gear group 77, carousel axle 79 and rotates, with the mixing cup rotatory to required reagent position, mixing motor 791 through mixing pulley group 792, mixing main shaft 793, first rotating gear 74, second rotating gear 75, a plurality of third rotating gear 76, drive a plurality of mixing cups 794 rotatory, realizes the rotatory mixing of M reagent bottle. The temperature of a refrigerating part of the reagent refrigerator is controlled to be 2-12 ℃.
As shown in fig. 14, the reaction tray module 8 includes a reaction tray rack 81, a reaction tray motor 82, a reaction tray pulley set 83, a reaction tray rotating shaft 84, a reaction tray 85, a reaction tray cup unloading mechanism 86, and a reaction tray heating member 87; the reaction tray motor 82 is installed on the reaction tray rack 81, an output shaft of the reaction tray motor 82 is connected with a reaction tray rotating shaft 84 through a reaction tray belt pulley group 83, the reaction tray rotating shaft 84 is rotatably installed on the reaction tray rack 81, the center of the reaction tray 85 is fixedly sleeved at the upper end of the reaction tray rotating shaft 84, the reaction tray cup unloading mechanism 86 is installed on the reaction tray rack 81 and located on one side of the reaction tray 85, and the reaction tray heating element 87 is installed on the reaction tray rack 81 and located on the bottom surface of the reaction tray 85. The reaction disc cup unloading mechanism 86 comprises a fixed rod 861, two electromagnetic valves 862 and two clamping rods 863; the outer end of a fixed rod 861 is fixed on the reaction tray rack 81, the inner end of the fixed rod 861 extends to the top surface of the reaction tray 85, two electromagnetic valves 862 are installed on the inner side of the fixed rod, two clamping rods 863 and two electromagnetic valves 862 are arranged oppositely, and the valve rods of the two electromagnetic valves 862 are respectively connected with the clamping rods 863; a washing tank 88 is installed on the reaction tray 81.
The working principle of the reaction disk module 8 is as follows: the whole structure is that the stepper motor synchronous belt drives to rotate to the required reaction cup carrying position. The heating part of the reaction disk module realizes the control of the temperature of the liquid in the reaction cup on the disk to be 37 +/-0.5 ℃.
As shown in fig. 16, the BF disk module 9 is substantially identical in construction to the reaction disk module 8 except that there is no reaction disk cup discharge mechanism 86.
As shown in fig. 17, the transfer and discard module 10 is substantially the same as the cuvette handling module 6.
As shown in fig. 18-20, the reagent dispensing module 20 includes a reagent rack 201, a reagent lifting motor 202, a reagent lifting pulley set 203, a reagent lifting screw 204, a reagent lifting guide rail 205, a reagent lifting seat 206, a reagent swinging motor 207, a reagent swinging pulley set 208, a reagent swinging disk 209, a reagent lifting rod 2010, a reagent needle rod 2011, and an aspiration needle 2012; the reagent lifting motor 202 is arranged at the bottom of the reagent rack 201, an output shaft of the reagent lifting motor 202 is connected with the lower end of a reagent lifting screw rod 204 through a reagent lifting belt pulley set 203, the reagent lifting screw rod 204 is rotatably arranged on the reagent rack 201, the upper part of the reagent lifting screw rod 204 is in threaded connection with a reagent lifting seat 206, the reagent lifting seat 206 is in sliding connection with a reagent lifting guide rail 205, and the reagent lifting guide rail 205 is fixedly arranged on the reagent rack 201 along the vertical direction; reagent swing motor 207 installs at the top of reagent frame 201, reagent swing motor 207's output shaft passes through reagent swing pulley group 208 and is connected with reagent swing dish 209, the lower extreme of reagent lifter 2010 is fixed on reagent lift seat 206, the middle part clearance of reagent lifter 2010 is worn to put in the slot at reagent swing dish 209 middle part and the slot at reagent swing dish 209 middle part is the groove block cooperation in the middle part of reagent lifter 2010, the upper end of reagent lifter 2010 is connected with the inner of reagent needle bar 2011 is perpendicular, the outer end of reagent needle bar 2011 is connected with sucking needle 2012 perpendicularly.
The operation principle of the reagent dispensing module 20:
reagent lifting motor 202 drives reagent lifting screw 204 to rotate through reagent lifting pulley set 203, lifting screw 204 drives reagent lifting seat 206 to lift, reagent swing motor 207 drives reagent swing disc 209 to swing through reagent swing pulley set 208, reagent swing disc 209 drives reagent lifting rod 2010 to swing, and then drives suction needle 2012 to swing.
As shown in fig. 21, a first embodiment of the cleaning module 30 comprises a cleaning frame 301, a cleaning motor 302, a cleaning screw 303, a cleaning slide 304, a cleaning needle holder 305, a cleaning needle 306, and a cleaning guide 307; the cleaning motor 302 is arranged on the cleaning rack 301, an output shaft of the cleaning motor 302 is connected with the lower end of the cleaning screw rod 303, the lower part of the cleaning screw rod 303 is rotatably arranged on the cleaning rack 301, the upper part of the cleaning screw rod 303 is in threaded connection with the cleaning slide base 304, the lower end of the cleaning needle support 305 is fixed on the cleaning slide base 304, the cleaning slide base 304 is in sliding connection with the cleaning guide rail 307, the cleaning guide rail 307 is fixedly arranged on the cleaning rack 301 and is arranged along the vertical direction, and a cleaning needle 306 is arranged on the upper part of the cleaning needle support 305.
As shown in FIG. 22, a second embodiment of cleaning module 30 is constructed substantially the same as the first embodiment of cleaning module 30, except that it has three cleaning needles 3061, 3062, and 3063.
As shown in fig. 23 to 25, the exciting liquid dispensing module 40 includes an exciting liquid rack 401, an exciting liquid lifting motor 402, an exciting liquid pulley set 403, an exciting liquid slide carriage 404, an exciting liquid support 405, an exciting liquid upper guide rail 406, two exciting liquid needles 407, an upper top seat 408, an upper guide rod 409, an upper press rod 4010, an upper spring 4011, an upper product seat 4012, an exciting liquid lower guide rail (not shown in the drawings), a cam 4014, a cam shaft 4015, a top wheel 4016, a lower top seat 4017, a lower guide rod 4018, a lower spring 4019, a lower product seat 4020, and a tension spring 4021.
The exciting liquid lifting motor 402 is fixed on an exciting liquid rack 401, an output shaft of the exciting liquid lifting motor 402 is connected with an exciting liquid pulley group 403, the exciting liquid pulley group 403 is installed on the exciting liquid rack 401, the lower end of an exciting liquid support 405 is connected with a belt on the exciting liquid pulley group 403, the lower end of the exciting liquid support 405 is connected with an exciting liquid sliding seat 404, the exciting liquid sliding seat 404 is connected on an exciting liquid upper guide rail 406 in a sliding manner, two exciting liquid needles 407 and an upper top seat 408 are both installed on the upper portion of the exciting liquid support 405, the upper end of an upper guide rod 409 is fixed on the upper top seat 408, an upper product seat 4012 is movably sleeved on the lower portion of the upper guide rod 409, the upper end of the upper product seat 4012 is connected with the upper top seat 408 through an upper pressing rod 4010, and an upper spring 4011 is sleeved on the upper pressing rod 4010 and is located between the. The inner end of the lower top seat 4017 is in sliding connection with an exciting submerged guide rail which is fixed on an exciting liquid rack 401, a lower product seat 4020 is movably arranged at the outer end of the lower top seat 4017 in a penetrating manner through a lower guide rod 4018, a lower spring 4019 is arranged between the lower product seat 4020 and the lower top seat 4017, a top wheel 4016 is rotatably arranged on the lower top seat 4017 and abuts against a cam 4014, and the cam 4014 is fixed on a lower belt pulley of an exciting liquid belt pulley group 403 through a cam shaft 4015 and is eccentric; two ends of the tension spring 4021 are respectively connected with the lower top seat 4017 and the exciting liquid rack 401 in a hanging manner.
The exciting liquid pulley group 403 comprises an upper pulley 4031, a lower pulley 4032, a first guide wheel 4033, a second guide wheel 4034, a third guide wheel 4035 and a belt 4036; the upper belt pulley 4031 and the lower belt pulley 4032 are arranged at the upper end and the lower end, the first guide wheel 4033, the second guide wheel 4034 and the third guide wheel 4035 are sequentially arranged from top to bottom, two ends of the belt 4036 are wound on the upper belt pulley 4031 and the lower belt pulley 4032, and the middle part of the belt 4036 passes through the space between the first guide wheel 4033 and the second guide wheel 4034 and then abuts against the inner side of the third guide wheel 4035.
The working principle of the invention is as follows:
the excitation liquid lifting motor 402 drives the cam 4014 to rotate through the excitation liquid belt pulley group 403, the cam 4014 drives the top wheel 4016 which is abutted against the cam 4014 to move up and down, the lower top seat 4017 is further driven to move up and down, up and down elastic pressing is realized, pre-excitation liquid/excitation liquid is dispensed to the reaction cup after the elastic pressing, chemiluminescence is generated, and a chemiluminescence detection module is used for detecting a luminescence value.
As shown in fig. 31 to 35, the blending module 50 includes a fixing bracket 1B, a screw rod 2B, a nut 3B, a driving motor 4B, a blending shaft 5B, and an eccentric block 6B.
Specifically, as shown in fig. 1 to 5, the fixing bracket 1B includes a top plate 11B, a bottom plate 12B, and a connecting member 13B having upper and lower ends respectively connected to the top plate 11B and the bottom plate 12B, and the top plate 11B is provided with a through hole 111B. As shown in fig. 31 and 32, the connecting members 13B may be a plurality of connecting rods 131B, the upper ends and the lower ends of which are respectively connected to the top plate 11B and the bottom plate 12B, and a gap may be formed between adjacent connecting rods 131B.
As shown in fig. 31 to 35, the screw rod 2B is vertically fitted in the fixing bracket 1B, and an annular protrusion 22B protruding outward from the side wall of the screw rod 2B is fitted at the top of the screw rod 2B; the driving motor 4B is arranged on the bottom plate 12B and is used for driving the screw rod 2B to rotate; the nut 3B is in threaded connection with the screw rod 2B, and the nut 3B is positioned below the annular bump 22B, so that the annular bump 22B can clamp the nut 3B to limit the upward movement of the nut 3B; the nut 3B can freely slide on the lead screw 2B, and the nut 3B can freely slide on the lead screw 2B means that the nut 3B can overcome the friction between the nut and the lead screw 2B under the action of self gravity to generate rotary falling, namely, the lead screw lead angle of the lead screw and the nut is larger than the equivalent friction angle of a lead screw pair formed by the lead screw and the nut. Wherein the lead screw can be a precise resin lead screw with parameters of 6mm diameter, 6mm lead and lead angle of more than 15 degrees. In addition, the screw rod 2B can be sleeved with an elastic washer 23B, and the top surface of the elastic washer 23B is abutted against the bottom surface of the annular bump 22B, so that the nut 3B is prevented from colliding with the annular bump 22B through the elastic washer 23B and being damaged.
As shown in fig. 31 to 35, the driving motor 4B can be locked and fixed below the bottom plate 12B by a screw, a through hole 121 is formed in the bottom plate 12B corresponding to an output shaft 41B of the driving motor 4B, and the output shaft 41B of the driving motor 4B is coaxially connected with the lower end of the screw rod 2B through a coupling 42B, so that the driving motor 4B can drive the screw rod 2B to rotate, in order to prevent the nut 3B from being damaged due to collision when slipping off, the outer diameter of the coupling 42B can be larger than the diameter of the screw rod 2B, the screw rod 2B is sleeved with an elastic gasket 21B, the bottom surface of the elastic gasket 21B abuts against the top surface of the coupling 42B, and thus the elastic gasket 21B can play a buffering role on the nut 3B to prevent the nut 3B from being damaged due to collision. It should be noted that the driving motor 4B is not limited to be coaxially connected with the screw rod 2B through the output shaft 41B thereof so that the driving motor 4B can drive the screw rod 2B to rotate, and the driving motor 4B can also drive the screw rod 2B to rotate through a gear transmission structure or a worm gear transmission structure.
As shown in fig. 31 to 35, the kneading shaft 5B is movably inserted into the through hole 111B of the top plate 11B, so as to guide the kneading shaft 5B through the top plate 11B of the fixing bracket 1B; the lower end of the blending shaft 5B is coaxially connected with the nut 3B, and the bottom of the blending shaft 5B is provided with a guide groove 51B in which a screw rod is movably sleeved, so that the blending shaft 5B can synchronously move along with the nut 3B; the side wall of the mixing shaft 5B may be provided with a limit bump 52B for abutting against the bottom surface of the top plate 11B to prevent the mixing shaft 5B from moving upwards to separate from the through hole 111B of the top plate 11B during the use.
As shown in fig. 31 to 35, the eccentric block 6B is connected to the upper end of the kneading shaft 5B, and the eccentric block 6B and the kneading shaft 5B are eccentrically disposed, so that the kneading shaft 5B can rotate to drive the eccentric block 6B to perform eccentric circular motion.
As shown in fig. 4, in a normal state of the kneading module 50, the driving motor 4B does not drive the screw rod 2B to rotate, and at this time, the nut 3B and the kneading shaft 5B drive the eccentric block 6B to slide down to the lowest position due to the self-weight. As shown in fig. 34 and 35, when the blending module 50 blends the reactant in the reaction cup a, the driving motor 4B drives the screw rod 2B to rotate at a high speed, and at this time, the nut 3B and the blending shaft 5B will rotate relative to the screw rod 2B due to static inertia, so that the nut 3B, the blending shaft 5B, and the eccentric block 6B can rise along the screw rod 2B; when the nut 3B rises to the annular convex block 22B at the top of the screw rod 2B to clamp the nut 3B, the blending shaft 5B and the eccentric block 6B do not rise any more, at the moment, the eccentric block 6B is propped against the bottom surface of the reaction cup A, and the nut 3B and the blending shaft 5B rotate along with the screw rod 2B, so that the eccentric block 6B connected with the upper end of the blending shaft 5B drives the bottom of the reaction cup A to do eccentric circular motion, and reactants in the reaction cup A are uniformly mixed by vibration; after the reactants in the reaction cup A are uniformly mixed by vibration, the driving motor 4B stops driving the screw rod 2B to rotate, and at the moment, the nut 3B and the mixing shaft 5B can drive the eccentric block 6B to slide downwards to the lowest position due to self weight.
Further, as shown in a matched figure 33, the blending shaft 5B can be made of metal, and the top plate 11B is matched with at least one magnet 7B, so that in the process that the nut 3B and the blending shaft 5B drive the eccentric block 6B to slide downwards to the lowest position due to self weight, the magnet 7B can generate attraction force on the blending shaft 5B, the nut 3B, the blending shaft 5B and the eccentric block 6B slowly fall down, and the nut 3B is prevented from being damaged due to collision. The bottom of the top plate 11B can form an embedded groove 112B for embedding the magnet 7B, in addition, the top plate 11B is also connected with a limiting plate 14B through a screw, and the magnet 7B is clamped between the top plate 11B and the limiting plate 14B to avoid the magnet 7B from falling off from the embedded groove 112B; in addition, two magnets 7B can be matched on the top plate 11B, and the two magnets 7B are symmetrically distributed about the blending shaft 5B, so that the blending shaft 5B is stressed uniformly, and the blending shaft 5B is prevented from deviating.
Further, as shown in fig. 31 to 35, the fixing bracket 1B further includes a vertical plate 15B, the bottom of the vertical plate 15B is connected to the bottom plate 12B, and the vertical plate 15B is located outside the connecting rod 131B, a position sensor 8B for sensing the position of the blending shaft 5B is fitted inside the vertical plate 15B, and the position sensor can adopt a light reflection position sensor, so that whether the blending shaft 5B ascends to a set position can be confirmed by the position sensor 8B.
As shown in fig. 1-3, the working principle of the present invention is:
1. sample introduction frame module 2: for sample rack placement (including emergency room sample racks), the user can load or unload the sample rack at the sample injection area. Each sample rack can hold 5 sample cups or test tubes. The sample racks are placed on sample rack trays, and each sample rack tray can be used for placing 5 sample racks. The sample rack is placed at the set position of the sample rack loading module through the tray, and the initial position is set for the sample to be inspected, so that the sample is correctly conveyed to the sampling position.
2. Sample rack transport module 3: the primary function is to transport the sample rack 100 to the sample station module 70; the sample rack 100 is transported back to the sample rack module 2.
3. Consumable box handling module 4: the main function is to transfer the pipette tip cartridge 200 and the cuvette cartridge 300 (shown in FIG. 7) from the consumable storage location to the sample dispensing module 5 (pipette tip insertion location) and the cuvette handling module 6 (cuvette insertion location), and to transfer the empty cartridge back to the consumable storage location.
4. Reagent refrigerator module 7: the device is mainly used for placing an M reagent bottle, an R1 reagent bottle, an R2 reagent bottle, a pretreatment reagent bottle and a sample diluent bottle in a refrigeration way.
5. The sample station module 70: the main function is to identify the sample rack and the sample, and transport the sample to the sampling position, and the sample rack returns to the initial position after sampling and is retrieved by the sample rack transport module.
6. Sample dispensing module 5: the main function is to insert the sample suction head from the sample suction head box, then sample the sample cup on the sampling platform, then transfer the obtained sample to the reaction cup on the immune reaction disc for sample adding, finally pull out the sample suction head and return to the initial position.
7. Reaction cup transfer module 6: for transporting the reaction cups from the reaction cup cassette transfer module to the reaction tray designated position and then returning to the original position.
8. Reaction disk module 8: the main functions are: (1) fixedly distributing the reaction cups sent by the reaction cup conveying module; (2) receiving a sample sent by a dispensing and sample adding module; (3) controlling various reagents conveyed by a reagent dispensing 1 module, a reagent dispensing 2 module, a diluent dispensing module, a washing module, a pre-excitation liquid dispensing module and an excitation liquid dispensing module, dispensing of diluent, washing of washing buffer solution and the like; (4) heating the reaction environment and keeping the reaction environment at a constant temperature; (5) mechanically mixing the reaction cups uniformly; (6) carrying out an immune reaction; (7) carrying out chemiluminescence reaction.
9. The BF disk module 9: and transferring the reaction cups of the immunoreaction disc to a specific position, or discarding the reaction cups after the reaction is finished in a waste box.
10. A blending module 50: the main function is to mix and stir the reagent, and the mixed reaction cup is correctly placed in the reaction disk.
11. Transfer discard module 10: the main function is to transfer the reaction cups to a designated position or discard the reaction cups after the reaction cups are completed in a waste bin.
12. Reagent dispensing module 20: and dispensing the reagent in the reagent bin into the reaction cup.
13. The cleaning module 30: the main function is to utilize a cleaning spray needle to dispense or absorb a cleaning buffer solution to clean the reaction cup.
14. Excitation liquid dispensing module 40: and (3) dispensing pre-excitation liquid/excitation liquid into the reaction cup in the test process.
The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims and their equivalents and modifications within the scope of the description.

Claims (13)

1. A full-automatic chemiluminescence immunoassay analyzer is characterized in that: the device comprises a main frame, a sample feeding frame module, a sample frame carrying module, a consumable box carrying module, a sample separate injection module, a reaction cup carrying module, a reagent refrigerator module, a reaction disk module, a BF disk module, a blending module, a transfer discarding module, two reagent separate injection modules, two cleaning modules and an exciting liquid separate injection module;
the sample injection rack module, the sample rack carrying module, the consumable box carrying module, the sample injection module, the reaction cup carrying module, the reagent refrigerator module, the reaction disk module, the BF disk module, the blending module, the transfer discarding module, the reagent injection module, the two cleaning modules and the exciting liquid injection module are all arranged on the main rack, and the outlet end and the inlet end of the sample injection rack module are connected with the inlet end and the outlet end of the sample rack carrying module; the first station of the sample dispensing module is a consumable box carrying module, the second station of the sample dispensing module is a sample rack carrying module, and the third station of the sample dispensing module is a reaction disc module; the first station of the reaction cup carrying module is a consumable box carrying module, and the second station of the reaction cup carrying module is a reaction disk module; the two reagent separate injection modules are respectively positioned at two sides of the reagent refrigerator module, the first station and the second station of one reagent separate injection module are the reagent refrigerator module and the reaction disk module, and the first station and the second station of the other reagent separate injection module are the reagent refrigerator module and the BF disk module; the three stations of the transfer discarding module are respectively a reaction disk module, a BF disk module and a garbage port arranged on the main rack; the two cleaning modules and the exciting liquid dispensing module are respectively arranged on one side of the BF disk module.
2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the sample feeding frame module comprises a sample feeding frame, three longitudinal conveying belts, two groups of deflector rod mechanisms and a code scanning mechanism; the three longitudinal conveying belts are arranged in the middle of the sample injection frame and are arranged in parallel along the longitudinal direction, the two groups of deflector rod mechanisms are arranged at the front end and the rear end of the sample injection frame and are arranged in parallel along the transverse direction, and the code scanning mechanism is arranged in the middle of the sample injection frame and is positioned between the two adjacent longitudinal conveying belts; the driving lever mechanism comprises a driving lever motor, a driving lever belt pulley group, a driving lever guide rail, a driving lever fork claw and two driving lever material channels, the driving lever motor is installed on the sample injection frame, an output shaft of the driving lever motor is connected with the driving lever fork claw through the driving lever belt pulley group, the driving lever fork claw is connected onto the driving lever guide rail in a sliding mode, the driving lever guide rail is fixedly installed on the sample injection frame, and the two driving lever material channels are fixedly installed on the sample injection frame in parallel and are located under the driving lever fork claw, so that the driving lever fork claw stirs the sample frame back and forth along the driving.
3. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the sample rack carrying module comprises a carrying rack, two carrying material channels, two carrying conveyer belts, a carrying portal frame, a carrying motor, a carrying belt pulley group and a carrying shifting fork; the two carrying material channels are arranged at the bottom of the carrying rack, the two carrying conveyer belts are arranged at the bottom of the carrying rack and are respectively located in the carrying material channels, the carrying portal frame is vertically arranged at the middle of the carrying rack, a carrying motor is fixedly arranged at the upper part of the carrying portal frame, an output shaft of the carrying motor is connected with the upper end of a carrying shifting fork through a carrying belt wheel group, the lower end of the carrying shifting fork extends to the upper parts of the two carrying material channels, the carrying shifting fork can move back and forth between the two carrying material channels, and the feeding ends and the discharging ends of the two carrying material channels are respectively connected with the two shifting rod material channels and the feeding end in the sample feeding frame module shifting rod mechanism.
4. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the consumable box carrying module comprises a box frame, a plurality of box partition plates, a box translation motor, a box translation belt pulley group, a box moving seat, a box translation guide rail, a box lifting motor, a box lifting belt pulley group, a box lifting guide rail and box fork claws; the box frame is fixed on the main frame, a plurality of box baffles are arranged in the box frame along the vertical direction at intervals, the box translation motor is installed on the box frame, an output shaft of the box translation motor is connected with the box moving seat through a box translation belt pulley group, the box moving seat is driven to move back and forth, the middle of the box moving seat is in sliding connection with the box translation guide rail, the box translation guide rail is fixed in the middle of the box frame, the box lifting motor is installed on the box moving seat, the output shaft of the box lifting motor is connected with the box fork claw through a box lifting belt pulley group, the box fork claw is in sliding connection with the box lifting guide rail, and the box lifting guide rail is installed on the box moving seat.
5. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the sample separate injection module comprises a separate injection rack, a separate injection horizontal guide rail, a separate injection sliding seat, a separate injection translation motor, a translation belt pulley set, a separate injection swing motor, a swing belt pulley set, a swing shaft, a swing seat, a swing rod, a gun tip grabbing rod, a separate injection lifting motor, a lifting belt pulley set, a lifting lead screw and a separate injection lifting guide rail; the horizontal dispensing guide rail is installed on the horizontal dispensing machine frame in the horizontal direction, the horizontal dispensing translation motor is fixed on the horizontal dispensing machine frame, the output shaft of the horizontal dispensing translation motor is connected with the dispensing sliding seat through the translation belt pulley set, the dispensing sliding seat is connected on the horizontal dispensing guide rail in a sliding mode, the dispensing swing motor is fixed on the dispensing sliding seat, the output shaft of the dispensing swing motor is connected with the upper end of the swing shaft through the swing belt pulley set, a shaft hole in the inner end of the swing seat is sleeved in the middle of the swing shaft and is connected through a groove block in a plugging mode, the swing seat can move up and down along the swing shaft without relative rotation, the swing seat is connected on the dispensing lifting guide rail in a sliding mode, the dispensing lifting guide rail is fixed on the dispensing sliding seat in the vertical direction, the dispensing lifting motor is installed on the dispensing sliding seat, the output shaft of the dispensing lifting motor, the inner end of the swing rod is fixed in the middle of the swing shaft, and the gun point grabbing rod is installed at the outer end of the swing rod.
6. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the reaction cup carrying module comprises a cup rack, a cup translation motor, a cup translation belt pulley group, a cup moving seat, a cup guide rail, a cup lifting motor, a cup lifting belt pulley group, a cup lifting seat, a cup gripping mechanism and a cup lifting screw rod; the cup lifting mechanism is characterized in that the cup translation motor is fixed on the cup frame, an output shaft of the cup translation motor is connected with the cup moving seat through the cup translation belt pulley group, the cup moving seat is connected with a cup guide rail in a sliding mode, the cup guide rail is installed on the cup frame, the cup lifting motor is installed on the cup moving seat, the output shaft of the cup lifting motor is connected with the upper end of the cup lifting screw rod through the cup lifting belt pulley group, the middle of the cup lifting screw rod is in screwed connection with the inner end of the cup lifting seat, and the upper portion of the cup grabbing mechanism is installed on the.
7. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein:
the reagent refrigerator module comprises a refrigerating tank, a turntable motor, a turntable belt pulley group, a first rotating gear, a second rotating gear, a plurality of third rotating gears, a turntable gear group, a turntable shaft, a blending motor, a blending belt pulley group, a blending main shaft, a plurality of blending cups and a refrigerating component; the rotary disc motor is arranged at the bottom of the refrigeration tank, an output shaft of the rotary disc motor is connected with the rotary disc shaft through a rotary disc belt wheel set, the rotary disc shaft is rotatably arranged at the bottom of the refrigeration tank and is connected with the rotary disc through a rotary disc gear set, and the center of the rotary disc is movably sleeved at the upper part of the blending main shaft; the blending motor is arranged at the bottom of the refrigeration tank, an output shaft of the blending motor is connected with a blending main shaft through a blending belt pulley group, the blending main shaft is rotatably arranged at the bottom of the refrigeration tank, the upper part of the blending main shaft penetrates through the turntable and then is fixedly sleeved in the center of the first rotating gear, the first rotating gear is meshed with the second rotating gear, the second rotating gear is meshed with a plurality of third rotating gears, the plurality of third rotating gears are mutually meshed, the plurality of third rotating gears are respectively fixedly sleeved on rotating shafts of the plurality of blending cups, the plurality of blending cups are respectively sleeved in a plurality of through holes on the periphery of the turntable, and the plurality of blending cups are uniformly arranged around the center of the turntable; the refrigeration component is arranged on the bottom surface of the refrigeration tank.
8. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the reaction disc module comprises a reaction disc rack, a reaction disc motor, a reaction disc belt pulley group, a reaction disc rotating shaft, a reaction disc cup unloading mechanism and a reaction disc heating element; the reaction disc heating device comprises a reaction disc motor, a reaction disc cup unloading mechanism, a reaction disc heating element, a reaction disc rotating shaft, a reaction disc cup unloading mechanism and a reaction disc heating element, wherein the reaction disc motor is arranged on a reaction disc frame, an output shaft of the reaction disc motor is connected with the reaction disc rotating shaft through a reaction disc belt pulley group, the reaction disc rotating shaft is rotatably arranged on the reaction disc frame, the center of the reaction disc is fixedly sleeved at the upper end of the reaction disc rotating shaft, the reaction disc cup unloading mechanism is arranged; the reaction disc cup unloading mechanism comprises a fixed rod, two electromagnetic valves and two clamping rods, wherein the outer end of the fixed rod is fixed on the reaction disc rack, the inner end of the fixed rod extends to the top surface of the reaction disc, the two electromagnetic valves are arranged on the inner side of the fixed rod, the two electromagnetic valves of the two clamping rods are arranged oppositely, and the clamping rods are connected to valve rods of the two electromagnetic valves respectively.
9. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the reagent separate injection module comprises a reagent rack, a reagent lifting motor, a reagent lifting belt pulley group, a reagent lifting lead screw, a reagent lifting guide rail, a reagent lifting seat, a reagent swinging motor, a reagent swinging belt pulley group, a reagent swinging disc, a reagent lifting rod, a reagent needle rod and a suction needle; the reagent lifting motor is arranged at the bottom of the reagent rack, an output shaft of the reagent lifting motor is connected with the lower end of a reagent lifting screw rod through a reagent lifting belt pulley group, the reagent lifting screw rod is rotatably arranged on the reagent rack, the upper part of the reagent lifting screw rod is in threaded connection with a reagent lifting seat, the reagent lifting seat is in sliding connection with a reagent lifting guide rail, and the reagent lifting guide rail is fixedly arranged on the reagent rack along the vertical direction; the reagent swing motor is installed at the top of the reagent rack, an output shaft of the reagent swing motor is connected with the reagent swing tray through the reagent swing belt pulley group, the lower end of the reagent lifting rod is fixed on the reagent lifting seat, a middle gap of the reagent lifting rod penetrates through a slot in the middle of the reagent swing tray, the middle of the reagent lifting rod is matched with the slot in the middle of the reagent swing tray through a slot block, the upper end of the reagent lifting rod is vertically connected with the inner end of the reagent needle rod, and the outer end of the reagent needle rod is vertically connected with the suction needle.
10. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the cleaning module comprises a cleaning rack, a cleaning motor, a cleaning screw rod, a cleaning sliding seat, a cleaning needle bracket, more than one cleaning needle and a cleaning guide rail; the cleaning machine is installed on the cleaning rack, an output shaft of the cleaning machine is connected with the lower end of the cleaning screw rod, the lower portion of the cleaning screw rod is rotatably installed on the cleaning rack, the upper portion of the cleaning screw rod is in threaded connection with the cleaning sliding seat, the lower end of the cleaning needle support is fixed on the cleaning sliding seat, the cleaning sliding seat is in sliding connection with the cleaning guide rail, the cleaning guide rail is fixedly installed on the cleaning rack and is arranged along the vertical direction, and more than one cleaning needle is installed on the upper portion of the cleaning needle support.
11. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: the exciting liquid separate injection module comprises an exciting liquid rack, an exciting liquid lifting motor, an exciting liquid belt pulley group, an exciting liquid sliding seat, an exciting liquid bracket, an exciting liquid upper guide rail, two exciting liquid needles, an upper top seat, an upper guide rod, an upper pressure rod, an upper spring, an upper product seat, an exciting liquid lower guide rail, a cam shaft, a top wheel, a lower top seat, a lower guide rod, a lower spring, a lower product seat and a tension spring; the device comprises an excitation liquid lifting motor, an excitation liquid pulley group, an excitation liquid sliding seat, an excitation liquid upper guide rail, two excitation liquid needles, an upper top seat, an upper spring, an upper top seat, an upper guide rod, an upper product seat, an upper pressure rod, an upper spring, an upper pressure rod and an upper product seat, wherein the excitation liquid lifting motor is fixed on an excitation liquid rack; the inner end of the lower top seat is connected to the exciting liquid lower guide rail in a sliding mode, the exciting liquid lower guide rail is fixed to the exciting liquid rack, the lower product seat penetrates through the outer end of the lower top seat in a movable mode through a lower guide rod, a lower spring is arranged between the lower product seat and the lower top seat, a top wheel is rotatably mounted on the lower top seat and abuts against a cam, the cam is fixed to a lower belt pulley of the exciting liquid belt pulley set through a cam shaft and is eccentric, and two ends of a tension spring are connected to the lower top seat and the exciting liquid rack in a hanging mode respectively.
12. The full-automatic chemiluminescence immunoassay analyzer of claim 11, wherein: the exciting liquid belt pulley set comprises an upper belt pulley, a lower belt pulley, a first guide wheel, a second guide wheel, a third guide wheel and a belt, wherein the upper belt pulley and the lower belt pulley are arranged at the upper end and the lower end, the first guide wheel, the second guide wheel and the third guide wheel are sequentially arranged from top to bottom, the two ends of the belt are wound on the upper belt pulley and the lower belt pulley, and the middle part of the belt passes through the space between the first guide wheel and the second guide wheel and then abuts against the inner side of the third guide wheel.
13. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein: still include the sample station module, this sample station module is installed on the main frame.
CN202010207575.6A 2020-03-23 2020-03-23 Full-automatic chemiluminescence immunoassay analyzer Pending CN111257579A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114397469A (en) * 2022-03-24 2022-04-26 宁波海壹生物科技有限公司 Consumable collecting equipment of full-automatic chemiluminescence analyzer
CN115327149A (en) * 2022-10-10 2022-11-11 湖南超亟检测技术有限责任公司 Full-automatic immunity analyzer and analysis and detection method thereof
CN116859071A (en) * 2023-09-05 2023-10-10 深圳市巨东生物医学工程有限公司 Full-automatic chemiluminescence immunoassay analyzer and detection analysis method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114397469A (en) * 2022-03-24 2022-04-26 宁波海壹生物科技有限公司 Consumable collecting equipment of full-automatic chemiluminescence analyzer
CN115327149A (en) * 2022-10-10 2022-11-11 湖南超亟检测技术有限责任公司 Full-automatic immunity analyzer and analysis and detection method thereof
CN116859071A (en) * 2023-09-05 2023-10-10 深圳市巨东生物医学工程有限公司 Full-automatic chemiluminescence immunoassay analyzer and detection analysis method thereof
CN116859071B (en) * 2023-09-05 2023-11-10 深圳市巨东生物医学工程有限公司 Full-automatic chemiluminescence immunoassay analyzer and detection analysis method thereof

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