WO2021134609A1 - Sample analyzing apparatus - Google Patents

Sample analyzing apparatus Download PDF

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Publication number
WO2021134609A1
WO2021134609A1 PCT/CN2019/130802 CN2019130802W WO2021134609A1 WO 2021134609 A1 WO2021134609 A1 WO 2021134609A1 CN 2019130802 W CN2019130802 W CN 2019130802W WO 2021134609 A1 WO2021134609 A1 WO 2021134609A1
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WO
WIPO (PCT)
Prior art keywords
reagent
action
sample
needles
component
Prior art date
Application number
PCT/CN2019/130802
Other languages
French (fr)
Chinese (zh)
Inventor
李鑫
闫华文
李爱博
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
北京深迈瑞医疗电子技术研究院有限公司
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Publication date
Application filed by 深圳迈瑞生物医疗电子股份有限公司, 北京深迈瑞医疗电子技术研究院有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to CN201980097764.8A priority Critical patent/CN114026430A/en
Priority to PCT/CN2019/130802 priority patent/WO2021134609A1/en
Publication of WO2021134609A1 publication Critical patent/WO2021134609A1/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the invention relates to a sample analysis device.
  • Sample analysis devices such as biochemical analyzers, immunoassay analyzers, coagulation analyzers, and cell analyzers, are instruments used to analyze and determine samples. Generally, reagents are added to the sample to pass the sample after reacting with the reagent. A certain way to measure the characteristics, chemical composition and concentration of the sample itself.
  • one of the cores is to decompose the complex measurement process into continuous and repeatable measurement cycles.
  • each component completes one or more predetermined actions, and then through the combination of different measurement cycles Realize different measurement processes.
  • test speed improves the sample processing capacity of the sample analysis device, thereby reducing the test time and obtaining the test results more quickly.
  • the key to improving the test speed is to shorten the measurement cycle time as much as possible, that is, to ensure that all parts of the instrument can complete all the tasks required for the scheduled measurement in the shortest possible time.
  • the reagent adding and dispensing process is a key link in the measurement process. How to complete all required actions in a short period of time is the key to improving the test speed of the sample analysis device. How to solve the contradiction between the shorter and shorter measurement period and the time occupied by complicated actions is the research of the present invention.
  • the present invention mainly provides a sample analysis device, which will be described in detail below.
  • an embodiment provides a sample analysis device, including:
  • the reaction cup loading parts are used to supply and carry empty reaction cups
  • Sampling component used to schedule the sample to be injected to the sample suction position
  • the sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
  • the reagent carrying component has a plurality of positions for carrying reagent containers
  • One or more processing units the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
  • the reagent dispensing part has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a set of the reagent needles; the reagent needles are used to suck from the reagent carrying part The reagents are discharged into the reaction cup of the corresponding processing unit, and each group of reagent needles includes at least two reagent needles;
  • the processor is used to control each reagent needle in the same group to sequentially perform multiple preset actions to complete the reagent adding operation, and at least among the multiple preset actions between two reagent needles in the same group There is a corresponding preset action that does not overlap in timing.
  • an embodiment provides a sample analysis device, including:
  • the reaction cup loading parts are used to supply and carry empty reaction cups
  • Sampling component used to schedule the sample to be injected to the sample suction position
  • the sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
  • a reagent carrying component is arranged in a disc-shaped structure and has a plurality of positions for carrying reagent containers, the reagent carrying component can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container To the suction position;
  • One or more processing units the processing unit is used to receive the cuvette carrying the sample dispatched by the scheduling component, and process the sample in the cuvette; wherein each processing unit is equipped with a corresponding reagent addition relay Bit; and
  • the reagent dispensing component has a reagent needle; the reagent needle is used to suck reagent from the reagent suction position and discharge it into the reaction cup positioned in the reagent adding; wherein each position in the reagent adding is configured with a set of the reagent needles
  • Each group of reagent needles includes at least two reagent needles, and the reagent needles are arranged in a manner of independently moving in a straight line between the reagent suction position and the corresponding reagent adding position;
  • a plurality of washing tanks are respectively arranged on the track of the linear movement of each reagent needle for cleaning the reagent needle;
  • the processor is used to control each reagent needle to sequentially perform a reagent suction action, a reagent heating action in the reagent needle, a reagent ejection action, and a reagent needle cleaning action to complete the reagent addition operation;
  • the sample analysis device includes a ping-pong mode, The processor executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles does not overlap in time sequence.
  • an embodiment provides a sample analysis device, including:
  • the reaction cup loading parts are used to supply and carry empty reaction cups
  • Sampling component used to schedule the sample to be injected to the sample suction position
  • the sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
  • the reagent carrying component has a plurality of positions for carrying reagent containers
  • One or more processing units the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
  • the reagent dispensing part has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a set of the reagent needles; the reagent needles are used to suck from the reagent carrying part The reagents are discharged into the reaction cup of the corresponding processing unit, and each group of reagent needles includes at least two reagent needles;
  • the processor is used to control each reagent to sequentially perform multiple preset actions to complete the reagent adding operation, and at least one of the multiple preset actions between the two reagent needles has a corresponding preset action There is no overlap in timing.
  • FIG. 1 is a schematic structural diagram of a sample analysis device according to an embodiment
  • FIG. 2 is a schematic structural diagram of a sample analysis device of another embodiment
  • FIG. 3 is a schematic structural diagram of a sample analysis device according to another embodiment
  • 4(a) and 4(b) are schematic diagrams of the structure of the reagent carrying member of two embodiments
  • FIG. 5 is a schematic diagram of the structure of a reagent carrying member according to another embodiment
  • FIG. 6 is a schematic structural diagram of a sample analysis device according to another embodiment
  • FIG. 7 is a schematic structural diagram of a reagent dispensing component of an embodiment
  • Fig. 8 is a schematic structural diagram of a reagent dispensing component of another embodiment
  • FIG. 9 is a schematic structural diagram of a reagent dispensing component according to another embodiment.
  • Fig. 10 is a schematic diagram of the structure of a reagent dispensing component according to another embodiment.
  • FIG. 11 is a schematic structural diagram of a sample analysis device according to another embodiment.
  • Figure 12 (a) is a schematic structural diagram of a transport component of an embodiment
  • Figure 12 (b) is a schematic structural diagram of a first transport component of an embodiment
  • Figure 12 (c) is a second transport component of an embodiment
  • FIG. 12(d) is a schematic diagram of the structure of the third transport component of an embodiment
  • Figure 13 is a schematic structural diagram of an embodiment of a cup grasping hand
  • FIG. 14 is a schematic structural diagram of a sample analysis device according to still another embodiment.
  • FIG. 15 is a schematic structural diagram of a sample analysis device according to still another embodiment.
  • Figure 16 is a schematic structural diagram of a cleaning component of an embodiment
  • FIG. 17 is a schematic flowchart of a sample analysis method according to an embodiment
  • FIG. 19 is a time sequence diagram of two reagent needles in the same group according to another embodiment.
  • FIG. 20 is a time sequence diagram of two reagent needles in the same group according to another embodiment.
  • FIG. 21 is a time sequence diagram of two reagent needles in the same group according to another embodiment.
  • Fig. 22 shows a method of a sample analysis device according to an embodiment.
  • connection and “connection” in the present invention include direct and indirect connection (connection) unless otherwise specified.
  • the sample analysis device is an instrument used to analyze and measure samples. Take the coagulation analyzer as an example to illustrate the test process of the sample analysis device.
  • the test procedure of a blood coagulation analyzer is generally as follows: complete sample addition and reagent addition into the reaction cup to prepare a reaction solution, and after mixing and incubating the reaction solution, the reaction cup is placed in the measurement part.
  • the measuring part can irradiate the reaction liquid in the cuvette with multi-wavelength light, and analyze it by coagulation method, immunoturbidimetric method, or chromogenic substrate method to obtain the coagulation reaction curve of the reaction liquid over time, so as to further calculate The clotting time of the reaction solution or other clotting-related performance parameters.
  • the time boundary conditions such as the addition time of the sample and the reagent and the incubation time must be strictly set in the test process. Set and control.
  • FIG. 1 is a schematic structural diagram of a sample analysis device according to some embodiments of the present invention.
  • the sample analysis device of some embodiments of the present invention may include a casing 1, a cuvette loading part 10, a sample part 20, a sample dispensing part 30, a reagent carrying part 40, one or more reagent dispensing parts 60, one or more The processing unit 50 and the scheduling component 70.
  • a casing 1 a cuvette loading part 10
  • sample part 20 a sample part 20
  • sample dispensing part 30 a sample dispensing part 30
  • reagent carrying part 40 one or more reagent dispensing parts 60
  • the processing unit 50 and the scheduling component 70 the scheduling component 70.
  • the example shown in FIG. 1 is an example with two reagent dispensing parts 60 and two processing units 50, but those skilled in the art will understand that this is only for example, and is not used to limit the reagents.
  • the number of the dispensing part 60 and the processing unit 50 can only be two. The following is
  • the casing 1 is the instrument housing of the sample analysis device.
  • it may have a box shape that is basically a cuboid or a cube, and its function may be to accommodate some parts of the sample analysis device.
  • the casing 1 includes a first side 1a along the first direction and a second side 1b along the second direction.
  • first direction and the second direction referred to herein may be perpendicular, for example, the first direction is the Y direction in the figure, and the second direction is the The X direction.
  • the cuvette loading part 10 is used for supplying and carrying empty cuvettes. In the working process of the sample analysis device, it is necessary to continuously use the empty reaction cup to complete each test item.
  • the sample analysis device adds samples and reagents to the empty reaction cup to prepare, incubate and measure the reaction solution to obtain the project’s results. Test Results.
  • the cuvette loading part 10 can load an empty cuvette to a predetermined position, and the sample dispensing mechanism sucks a sample from the sample part 20 and discharges it into the empty cuvette at the predetermined position.
  • the sample part 20 is used to supply a sample rack carrying a sample to be tested.
  • the sample component 20 may be arranged in the casing 1.
  • the sample part 20 can be implemented in multiple ways.
  • the sample component 20 may be a sample injection component 21, and the sample injection component 21 is used to schedule the sample rack carrying the sample to the sample suction position.
  • Fig. 2 is an example.
  • the sampling component 21 may include a loading area 21a, a sampling channel 21b, and an unloading area 21c, wherein the sampling channel 21b may be provided with a sample suction position 21d.
  • the X direction and the Y direction are perpendicular
  • the X1 direction and the X2 direction are opposite directions
  • the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a.
  • the loading area 21a moves the sample rack to the Y1 direction in the figure to enter the sampling channel 21b.
  • the sample rack can move along the X1 direction in the sampling channel 21b and pass through the suction. Sample position, the sample on the sample rack can be sucked by the sample dispensing part 30 when passing the sample aspiration position. After the sample rack enters the unloading area 21c from the sampling channel 21b along the Y2 direction, the user can take it out of the unloading area 21c Sample rack.
  • the sample injection component 21 is more suitable for large-scale sample testing occasions, and the sample injection component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to the test system in the form of an assembly line, the sample injection component 21 can be directly connected. tear down.
  • the sample component 20 may be a sample placement area 22, and the sample placement area 22 is used to place a sample rack carrying a sample to be tested.
  • Figure 3 is an example.
  • the sample placement area 22 can have multiple channels 22a, and each channel 22a can place a sample rack. The user can push the sample rack into the channel 22a along the Y1 direction in the figure; the sample dispensing component 30 can suck the sample racks in each channel 22a in turn After the samples on the sample rack are all sucked, the user can pull the sample rack out of the channel 22a along the Y2 direction in the figure.
  • the sample placement area 22 does not require scheduling of the sample rack, so it occupies a small volume, which is beneficial to reduce the size of the sample analysis device, and is very beneficial to the miniaturized design of the sample analysis device.
  • the sample dispensing component 30 is used for aspirating samples from the sample suction position and discharging them into the reaction cup located at the sample adding position.
  • the sample dispensing component 30 may be arranged in the casing 1.
  • the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction.
  • the sample suction position and the predetermined position where the cuvette loading part 10 loads the empty cuvette can be designed to be on a straight line, such as a straight line along the first direction.
  • the sample needle only needs to reciprocate between the sample suction position and the above-mentioned predetermined position in the first direction, which not only improves the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very important for the miniaturization design of the sample analysis device. favorable.
  • the reagent carrying component 40 is used to carry reagents.
  • the reagent carrying component 40 may have multiple positions for carrying reagent containers, and the reagent containers are used to carry reagents.
  • the reagent carrying member 40 can provide functions such as refrigeration for the carried reagent, so as to ensure the activity of the reagent.
  • the reagent carrying member 40 may be disposed in the casing 1.
  • the reagent carrying member 40 is arranged in a disk-shaped structure, which has a plurality of positions for carrying reagent containers, and the reagent carrying member 40 can rotate and drive the reagent container carried by it to transfer, thereby rotating the reagent container to suction.
  • the reagent position is used for the reagent dispensing part 60 to suck reagents—for example, the reagent carrying part 40 includes a first driving assembly for driving the reagent carrying part 40 to rotate, and the first driving assembly drives the reagent carrying part 40 to rotate to rotate the reagent container to Suction reagent position.
  • the reagent carrying member 40 arranged in a disk-shaped structure will be described in detail below.
  • the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for placing the reagent coupling cup 41, each of the reagent coupling cups 41 includes one or more A cavity for containing reagents required for project testing, a kind of reagent is placed in a cavity; the reagent carrying member 40 includes a first driving component for driving it to rotate, and the first driving component drives the reagent carrying component 40 to rotate , Used to rotate the cavity of the reagent union cup 41 containing the reagents required by the project to the corresponding reagent suction position.
  • the reagent coupling cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent.
  • the reagent coupling cup 41 includes at least a mixed reagent R1.
  • the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for the first reagent container 42 for carrying the first reagent, and has a plurality of At the position of the second reagent container 43 that carries the second reagent.
  • the reagent carrying component 40 includes a first driving component for driving the rotation of the reagent carrying component 40, and the first driving component drives the reagent carrying component 40 to rotate and drives the first reagent container 42 to rotate, so as to rotate the first reagent container 42 to the first reagent suction position;
  • the first driving component drives the reagent carrying member 40 to rotate and drives the second reagent container 43 to rotate, so as to rotate the second reagent container 43 to the second reagent suction position.
  • the reagent carrying member 40 may include multiple tracks that can rotate independently.
  • the reagent carrying member 40 may include two tracks-an inner ring and an outer track.
  • a plurality of positions for the first reagent container 42 can be arranged on the outer ring track, and correspondingly, a plurality of second reagents can be arranged on the inner ring track.
  • the position of the container 43 drives the inner ring and the outer ring track to rotate independently through the first drive assembly.
  • FIG. 4(a) is an example of placing the reagent coupling cup 41
  • FIG. 4(b) is an example of realizing the reagent carrying member 40 through a track that can rotate independently.
  • the skilled person can understand that these two ways can also be combined to realize the reagent carrying member 40 through multiple tracks that can rotate independently, and at least one track or each track has multiple coupling cups 41 for placing reagents.
  • Figure 5 is an example of this.
  • the reagent carrying member 40 can include two tracks—inner and outer tracks.
  • the outer track can be provided with multiple positions for the reagent coupling cup 41.
  • the inner The ring track may also be provided with multiple positions for placing the reagent coupling cup 41, and the inner ring and the outer ring track are driven to rotate independently by the first drive assembly.
  • the above are some descriptions of the reagent carrying member 40.
  • the reagent carrying part 40 can rotate and dispatch the corresponding reagent required by the test item to the reagent suction position corresponding to the reagent dispensing part 60 by rotating during the working cycle, for example, dispatch the first reagent to the first reagent suction position, The second reagent is dispatched to the second reagent suction position.
  • the processing unit 50 is used to receive a reaction cup carrying a sample, and process the sample in the reaction cup.
  • the sample here refers to a reaction solution composed of a sample and a reagent. There may be one or more processing units 50.
  • the processing unit 50 is a reaction component 51 for incubating a sample, and the reaction component 51 is used to carry a reaction cup and incubate the sample in the reaction cup.
  • the reaction component 51 has a rectangular shape and has a plurality of reaction cup placement positions.
  • the reaction component 51 can heat the reaction solution or sample in the reaction cups on each reaction cup placement position to incubate the sample, for example, heat the sample in the reaction cup and keep it at 37 ⁇ 0.5 °C, the specific heating time and heating temperature can be determined by the heating parameters corresponding to different test items.
  • the length direction of the reaction member 51 is arranged along the first direction, for example, along the Y direction in the figure.
  • At least one of the processing unit 50 is a measuring part 52 for measuring a sample.
  • the measuring part 52 is used to carry a cuvette and detect the sample in the cuvette; in some embodiments, the measuring part 52 is Rectangular shape, with multiple reaction cup placement positions.
  • the measuring component 52 can be equipped with a detection part (not shown in the figure) for each reaction cup placement position, and each detection part is used to detect the sample in the reaction cup at the corresponding cuvette placement position.
  • the length direction of the measuring component 52 is arranged along a second direction different from the first direction, for example, along the X direction in the figure.
  • reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40 in an adjacent manner. In some specific embodiments, the reaction component 51 and the measurement component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying member 40 in an adjacent manner.
  • the rectangular reaction part 51 and the measuring part 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying part 40 in an adjacent manner, which can save space and reduce the size of the sample analysis device. At the same time, it is also advantageous for the reagent carrying part 40 to interact with the reaction part 51 and the measuring part 52 through the reagent dispensing part 60.
  • the sample component 20 such as the sample injection component 21, the cuvette loading component 10, the reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40.
  • This application is centered on the reagent carrying component 40, and the scheduling trajectory of the entire detection process of the reaction cup is designed around the reagent carrying component 40, which is novel in design and saves space.
  • Each processing unit 50 may be configured with a corresponding transposition during reagent addition.
  • the reaction component 51 is configured with at least one transposition 51a during incubation for placing a reaction cup, and the number of transposition 51a during incubation can be one or more;
  • the incubation transposition 51a can be set in a position adjustable manner, so that the reaction cup placed on the incubation transposition 51a can be combined with the first reagent dispensing part (No.
  • a reagent dispensing part is corresponding to the reaction part, and each reagent needle in the reaction cup in the reaction part is corresponding to the position to receive the reagent dispensed by each reagent needle.
  • the indexing position 51 a is arranged between the reagent carrying part 40 and the reaction part 51 during the incubation.
  • the measurement part 52 is configured with at least one mid-measurement index 52a for placing the reaction cup, and the number of mid-measurement index 52a can be one or more; in some embodiments, the mid-measurement index 52a is provided on the reagent carrying member 40 and Between parts 52.
  • the measuring index 52a When the position of the measuring index 52a for placing the reaction cup is set to 1, the measuring index 52a can be set in a position adjustable manner, so that the reaction cup placed on the measuring index 52a can be combined with the second reagent dispensing part (
  • the second reagent dispensing part corresponds to the measuring part, and the reagent needles in the reaction cup in the measuring part are matched in position to receive the reagent dispensed by the reagent needles.
  • FIG 6 shows that the number of transposition 51a in the incubation is one, and each transposition 51a in the incubation has two placement positions for the reaction cup, for example, the first position and the second position for placing the reaction cup; the transposition 52a is measured during the incubation.
  • the number is one, and each index 52a has two placement positions for the reaction cup in each measurement, for example, the third position and the fourth position for placing the reaction cup.
  • the reagent dispensing component 60 is used for sucking reagents from the reagent suction position and discharging them into the reaction cup of the reagent adding position.
  • the reagent dispensing part 60 can suck the first reagent from the first reagent suction position mentioned herein and discharge it into the reaction cup; the reagent dispensing part 60 can suck the second reagent from the second reagent position mentioned herein side by side. Put it in the reaction cup.
  • the reagent dispensing component 60 may be disposed in the casing 1.
  • the reagent dispensing unit 60 can be realized by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, and the reagent needle is used to suck the reagent from the reagent carrying component 40 and discharge it into the reaction cup.
  • the reagent dispensing part 60 may have multiple reagent needles, and the reagent needles are arranged in a manner that can move independently of each other.
  • the reagent needles can be configured as follows: each processing unit 50 is equipped with a group of reagent needles; the reagent needles are used to suck reagents from the reagent carrying member 40 and discharge them into the reaction cups of the corresponding processing units 50, and each group of reagent needles At least two reagent needles are included.
  • a set of reagent needles may be configured for the reaction part 51, and a set of reagent needles may be configured for the measurement part 52.
  • the reaction part 51 may be configured with a first set of reagent needles.
  • the first set of reagent needles are arranged in a linear motion between the reagent suction position and the incubation position 51a.
  • the first group of reagent needles For sucking reagents from the reagent suction position and discharging them into the reaction cup located at the incubation position 51a, the first set of reagent needles includes at least one reagent needle; similarly, a second set of reagent needles can be configured for the measurement component 52, and the second set of reagent needles
  • the reagent needles of the group are arranged in a linear motion between the reagent suction position and the indexing position 52a in the measurement.
  • the second group of reagent needles are used to suck reagents from the reagent suction position and discharge them into the reaction cup at the indexing position 52a in the measurement.
  • the second group of reagent needles includes at least one reagent needle.
  • the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50.
  • Figures 1 to 3 above are examples of this.
  • there may be two reagent dispensing components 60 the reaction component 51 corresponds to one of the reagent dispensing components 60, and the measuring component 52 corresponds to the other reagent dispensing component 60.
  • a reagent dispensing component 60 is configured for each processing unit 50 to decompose the action of the reagent adding process of the test item, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50, which makes The sample addition of the corresponding reagents of the test items is completed by division of labor, which is beneficial to improve efficiency.
  • each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 for linear movement, and drives the plurality of reagent needles 61 to move along the guide assembly 62
  • the second drive assembly 63 for linear motion.
  • the guide assembly 62 is arranged along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60, so that the reagent needle 61 sucks the reagent from the reagent suction position and discharges it to the reagent dispensing part.
  • the reagent dispensing part 60 corresponds to the reaction cup of the transposition in the reagent adding process unit 50 of the processing unit 50.
  • the reagent dispensing part 60 on the left side in FIG. 7 has a guide assembly 62 arranged along the direction determined by the incubation position 51a of the reagent suction position and the reaction part 51, so that the reagent needle 61 of the reagent dispensing part 60 is removed from the suction position.
  • the reagent position sucks reagents and discharges them into the reaction cup located at the incubation position 51a; the reagent dispensing part 60 on the right in FIG. 7 is determined by the guide assembly 62 along the reagent suction position and the measuring position 52a of the measuring part 52.
  • the direction is set so that the reagent needle 61 of the reagent dispensing part 60 sucks the reagent from the reagent suction position and discharges it into the reaction cup located at the index 52a in the measurement.
  • the number of the second driving components 53 of each reagent dispensing part 60 is equal to the number of the reagent needles 61, and the respective independent driving force output ends of the plurality of second driving components 53 act on the plurality of reagent needles 61 accordingly.
  • FIG. 7 is an example in which each reagent dispensing part 60 includes two reagent needles 61, and each reagent needle 61 is independently driven by a respective second driving assembly 63.
  • FIG. 8 is a schematic view of the side surface of the reagent dispensing member 60.
  • the guide assembly 62 of each reagent dispensing part 60 includes: a beam 62a, and a plurality of guides 62b arranged in parallel and along the length of the beam 62a; the beam 62a extends along the reagent suction position and corresponds to
  • the processing unit 50 of the reagent dispensing part 60 is set in the direction determined by the transposition in the reagent addition; the number of guides 62b is equal to the number of reagent needles 61 of the reagent dispensing part 60, and the plurality of reagent needles 61 are respectively connected to the plurality of guides 62b is slidably connected, so that the reagent needle 61 moves linearly along the guide 62b between the reagent sucking position and the reagent adding position.
  • each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guides 62b, and the two guides 62b are linear guides; The two linear guides are respectively arranged on both sides of the beam 62a along the long axis of the beam 62a- Figure 8 shows a schematic diagram of one side of the beam 62a, and the structure on the other side exposes a reagent needle 61; The reagent needles 61 are respectively arranged on the linear guide rails on both sides of the beam 62a and slidably connected with the linear guide rails; the reagent needle 61 moves linearly between the reagent suction position and the reagent adding position along the linear guide rail on which it is located.
  • a reagent needle is provided on both sides of a beam to realize a reagent dispensing part.
  • the guide assembly 62 of each reagent dispensing part 60 includes: a plurality of parallel beams 62a, and a plurality of beams 62a are respectively arranged on the plurality of the above and along the above
  • a guide 62b is provided in the length direction of the cross beam 62a; a plurality of the above cross beams 62a are provided along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60; the number of the guide 62b is related to the reagent distribution.
  • the number of reagent needles 61 of the injection part 60 is equal, and the reagent needles 61 are respectively slidably connected to the guide members 62b, so that the reagent needles 61 move linearly along the guide member 62b between the reagent suction position and the reagent adding position.
  • the plurality of guides 62b of each reagent dispensing part 60 are linear guides, and the plurality of linear guides are respectively arranged along the longitudinal direction of the plurality of beams 62a; the plurality of reagent needles 61 are respectively arranged on the plurality of beams 62a.
  • 62a is on the linear guide rail and is slidably connected to the linear guide rail; the reagent needle 61 moves linearly between the reagent suction position and the reagent loading position along the linear guide rail where it is located.
  • the beam 52a of the guide assembly 52 in each reagent dispensing component 60 is fixedly arranged at the reagent suction position and the upper position of the reagent adding position of the processing unit 50 corresponding to the reagent dispensing component 60.
  • the cross-beam structure realizes the reagent dispensing part 60 with multiple needles moving linearly.
  • the movement trajectory of the reagent needle 61 does not take up too much space and minimizes the layout interference with other parts, so that the structure of the sample analysis device can be more compact and very compact. It is conducive to the miniaturization design of the sample analysis device.
  • the trajectories of the reagent needles 61 of different reagent dispensing parts 60 do not intersect each other, so that the movement of the reagent needles 61 of different reagent dispensing parts 60 will not be interfered with each other. , Is conducive to improving the test speed.
  • the transposition during reagent addition includes the same number of reaction cup placement positions of the reagent needle 61 of the reagent dispensing part 60 corresponding to the processing unit 50.
  • the reagent-adding transposition of the reaction component 51 is the incubation transposition 51a in the figure, and the incubation transposition 51a can place two reaction cups; the reagent of the reagent dispensing component 60 corresponding to the reaction component 51
  • the number of needles 61 is two.
  • the reagent-adding indexing position of the measuring part 52 is the measuring indexing position 52a in the figure.
  • the measuring indexing position 52a can hold two reaction cups; the number of reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 There are two. In some embodiments, the number of reagent suction positions is the same as the number of reagent needles. For example, there are two reagent dispensing parts 60 in FIG. 6, and each reagent dispensing part 60 has two reagent needles 61, so the number of reagent suction positions is four. The number of reagent needles and the number of reagent adding positions are the same, so that each reagent needle can clearly divide the labor, and adding reagents to the reaction cups on the respective reagent adding positions is beneficial to increase the test speed.
  • the reagent needle 61 in the same reagent dispensing part 60 is used to suck the same type of reagent.
  • the reagent needles 61 of the reagent dispensing part 60 corresponding to the reaction part 51 are all used for aspirating the first reagent
  • the reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 are all used for aspirating the second reagent.
  • Different reagent dispensing parts 60 are used to suck different reagents, which makes the division of labor of each reagent dispensing part 60 clear, which is beneficial to increase the test speed.
  • each reagent needle 61 of the reagent dispensing component 60 is provided with a heating component (not shown in the figure) for heating the reagent sucked by the reagent needle. Since each reagent dispensing part 60 includes multiple reagent needles 61, two reagent needles may be used as an example. Each reagent needle 61 is further provided with a heating part. Since there are two reagent needles 61, the original speed is maintained.
  • Each reagent needle 61 has sufficient time—for example, doubled the time to heat the sucked reagent, so that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already relatively close to the predetermined temperature, that is, The reagents have been fully preheated.
  • the number of the processing unit 50 may be two, and specifically the reaction component 51 and the measuring component 52 as an example, to illustrate the matching relationship and the corresponding structure of the reagent dispensing component 60 and the processing unit 50.
  • the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component
  • the reagent dispensing component 60 corresponding to the measuring component 52 is a second reagent dispensing component, which will be described in detail below.
  • the first reagent dispensing part 60 includes a first beam 6a and a first set of reagent needles.
  • the first set of reagent needles includes at least a plurality of first reagent needles 6b, such as two; 61 is arranged on the first beam 62a and moves linearly along the long axis of the first beam 62a to suck the first reagent from the first reagent suction position and discharge it into the reaction cup located at the incubation position 51a.
  • the first beam 62a is arranged along the direction determined by the first reagent suction position and the incubation index 51a, and the first beam 62a is fixed at the upper position corresponding to the first reagent suction position and the incubation index 51a.
  • the first crossbeam 62a of the first reagent dispensing part 60 is set as one, and the multiple first reagent needles 61 described above are arranged in parallel on this first crossbeam 62a, and are arranged along the first crossbeam 62a. Make a linear movement in the direction of the long axis.
  • a linear guide rail is respectively provided on both sides of the first cross beam 62a along the long axis direction, and the two first reagent needles 61 are respectively provided on the first cross beam 62a.
  • the first reagent needle 61 moves linearly along the linear guide rail where it is located between the first reagent suction position and the incubation index 51a.
  • a first reagent needle is provided on both sides of a first beam to realize the first reagent dispensing part.
  • the number of the first beams 62a of the first reagent dispensing part 60 is equal to the number of the first reagent needles 61 of the first group of reagent needles, and each of the first beams 62a is provided with a first reagent. Needles 61, and two of the above-mentioned first beams 62a are arranged parallel to each other.
  • each of the plurality of first beams 62a is provided with a linear guide along its long axis, and the plurality of first reagent needles 61 are respectively provided on the linear guides of the plurality of first beams 62a for the first reagent
  • the needle 61 moves linearly between the first reagent suction position and the incubation position 51a.
  • the first reagent dispensing component 60 further includes a plurality of driving mechanisms that independently drive a plurality of first reagent needles to move linearly, such as a second driving assembly, the number of the plurality of second driving assemblies is different from the number of the first reagent needles.
  • the number of reagent needles is equal, and the independent driving force output ends of the plurality of second driving components act on the plurality of first reagent needles to drive the plurality of first reagent needles in the first suction along the long axis direction of the first beam. There is a linear movement between the reagent position and the transposition 51a during the incubation.
  • the indexing position 51a in the above incubation includes the first position and the second position for placing the reaction cup as an example.
  • the first reagent dispensing part 60 has two first reagent needles 61
  • one of the first reagent needles 61 is The reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the first position
  • the other first reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the second position .
  • the first reagent dispensing component 60 further includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction.
  • the number of the components 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles;
  • the first Z-direction drive components 64 all include: a first Z-direction for guiding the first reagent needle 61 to move in the vertical direction A guide member 64a, and a first Z-direction driving member 64b for driving the first reagent needle to move along the first Z-direction member;
  • the first reagent needle 61 is driven by the first Z-direction member 64a and the first Z-direction
  • the member 64b forms a sliding connection with the first beam 62a, so that the first reagent needle 61 can move in the vertical direction relative to the first beam 62a under the drive of the first Z-direction driving member 64b.
  • the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.
  • the second reagent dispensing part 60 includes a second beam 62a and a second set of reagent needles.
  • the second set of reagent needles includes at least a plurality of second reagent needles 61, such as two; the plurality of second reagent needles 61 are provided in the second group of reagent needles.
  • the second beam 62a is arranged along the direction determined by the second reagent suction position and the measuring index 52a, and the second beam 62a is fixedly arranged at the upper position corresponding to the second reagent suction position and the measuring index 52a.
  • the second crossbeam 62a of the second reagent dispensing part 60 is provided as one, and the multiple second reagent needles 61 described above are provided in parallel on this second crossbeam 62a and run along the second crossbeam 62a. Make a linear movement in the direction of the long axis.
  • a linear guide rail is respectively provided on both sides of the second cross beam 62a along the long axis direction, and the two second reagent needles 61 are respectively provided on the second cross beam 62a.
  • the second reagent needle 61 moves linearly between the second reagent suction position and the measuring index 52a along the linear guide rail where it is located.
  • a second reagent needle is provided on both sides of a second beam to realize the second reagent dispensing part.
  • the number of the second beams 62a of the second reagent dispensing part 60 is equal to the number of the second reagent needles 61 of the second group of reagent needles, and each of the second beams 62a is provided with a second reagent. Needles 61, and two of the above-mentioned second beams 62a are arranged parallel to each other.
  • each of the plurality of second beams 62a is provided with a linear guide along its long axis, and the plurality of second reagent needles 61 are respectively provided on the linear guides of the plurality of second beams 62a for the second reagent.
  • the needle 61 moves linearly between the second reagent suction position and the measuring index 52a.
  • the second reagent dispensing component 60 further includes a plurality of driving mechanisms that are different from the second driving assembly and independently drive a plurality of second reagent needles to move linearly, such as a third driving assembly, and a third driving mechanism.
  • the number of driving components is equal to the number of the second reagent needles, and the independent driving force output ends of the third driving components act on the second reagent needles to drive the second reagent needles.
  • the reagent needle moves linearly along the long axis direction of the second beam between the second reagent position and the indexing position in the measurement.
  • the structure of the second driving component and the third driving component may be the same.
  • the indexing position 52a includes the third position and the fourth position for placing the reaction cup in the above-mentioned measurement.
  • the second reagent dispensing part 60 has two second reagent needles 61
  • one of the second reagent needles 61 is The reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the third position
  • the other second reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the fourth position .
  • the second reagent dispensing component 60 further includes a second Z-direction driving assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction, respectively, and the second Z-direction driving
  • the number of the components 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles;
  • the second Z-direction drive components 64 all include: a second Z-direction for guiding the second reagent needle 61 to move in the vertical direction
  • the guide member 64a, and the second Z-direction driving member 64b for driving the second reagent needle 61 to move along the second Z-direction member 64a;
  • the second reagent needle 61 is driven by the second Z-direction member 64a and the second Z-direction
  • the member 64b forms a sliding connection with the second beam 62a, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z
  • the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.
  • the trajectory of the linear movement of the plurality of first reagent needles 61 of the first reagent dispensing component 60 between the first reagent suction position and the incubation position 51a is the first movement trajectory;
  • the trajectory of the linear movement of the multiple second reagent needles 61 of the injection component 60 between the second reagent suction position and the indexing position 52a in the measurement is the second movement trajectory; wherein the first movement trajectory is different from the second movement trajectory cross.
  • the structure of the first reagent dispensing part 60 and the second reagent dispensing part 60 may be the same, except that they are arranged in different directions.
  • the first reagent dispensing part 60 is arranged in the direction of the reaction part 51 to be used with the reaction part 51.
  • the second reagent dispensing part 60 is provided in the direction of the measuring part 52 to cooperate with the measuring part 52.
  • the above are some descriptions of the reagent dispensing unit 60.
  • the reagent dispensing part 60 adopts a beam structure, so that the reagent needle 61 continuously reciprocates between the reagent suction position of the reagent carrying part 40 and the reagent adding position of the corresponding processing unit to complete the suction and discharge of the corresponding reagent.
  • the movements of the different reagent dispensing parts 60 are independent and do not interfere with each other, and therefore play a significant role in the miniaturization of the instrument space and the improvement of the test speed.
  • the scheduling component 70 is used to schedule the reaction cups. For example, the scheduling component 70 schedules the reaction cups located in the sample loading position to complete the sample addition to each processing unit 50 according to the detection process. For example, the scheduling component 70 transfers the reagents to the position 51a during the incubation. For example, the reaction cup of the first reagent is dispatched to the reaction unit 51, and the reaction cup to which the reagent such as the second reagent has been added to the index 52a during the measurement is dispatched to the measurement unit 52.
  • the specific structure of the scheduling component 70 will be described below.
  • the scheduling component 70 includes a first transfer component 71, a second transfer component 73, and a third transfer component 75.
  • the sample The analysis device is also provided with a first buffer index 77 and a second buffer index 78.
  • the index 77 in the first buffer can be designed with a fixed buffer position, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device; similarly, the first The indexing position 78 in a buffer can be designed with a fixed buffer position, and has only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device.
  • the first buffer index 77 and the second buffer index 78 adopt a fixed buffer design, they can also be designed to have multiple cuvette placement positions, so that there are more cuvettes in the scheduling. Place a bit.
  • the index 77 in the first buffer may be designed as a moving or rotating buffer position.
  • the index 77 in the first buffer may include a reaction cup placement position that can be driven to move or rotate.
  • the first buffer index 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the first transfer part 71.
  • the first buffer index 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer part 73 Faster grabbing the cuvette on the index 77 in the first buffer; similarly, the index 78 in the second buffer may include a cuvette placement position that can be driven to move or rotate, so that the reaction cup in the second transfer part 73 During the transfer of the cuvette to the index 78 in the second buffer, the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the second transfer member 73.
  • the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position so that the third transfer part 75 can grab faster Transfer the reaction cup on 78 to the second buffer; through this design, the entire transfer process of the reaction cup can be made faster and less time-consuming, which improves the efficiency and test speed of the sample analysis device.
  • the first transfer component 71, the second transfer component 73 and the third transfer component 75 such as a rail-type transfer component, which transfers the cuvette by placing the cuvette on the rail; another example is a turntable type.
  • a rail-type transfer component which transfers the cuvette by placing the cuvette on the rail
  • another example is a turntable type.
  • the reaction cup carried by the turntable is transferred to the corresponding position by the transfer of the turntable itself; for example, the two-dimensional or three-dimensional drive mechanism is used to drive the gripper
  • the reaction cup is grasped by the cup grasping hand, and then the two-dimensional or three-dimensional driving mechanism is used to drive the cup grasping hand to move.
  • the cuvette is transferred to the corresponding position, and the following description may be given by using a cup gripper to realize the transfer part.
  • the first transfer component 71, the second transfer component 73 and the third transfer component 75 all include a cup gripper 79 and a driving component for driving the cup gripper 79 to move.
  • the cup gripper 79 is used to hold the reaction cup.
  • FIG. 13 is a schematic structural diagram of the cup gripper 79.
  • the opening and closing of the cup gripper 79 can be realized by a driving mechanism and a spring.
  • the opening of the cup gripper 79 can be driven by its driving mechanism.
  • the driving mechanism is not driven, the cup gripper 79 is automatically opened by its spring. Close and clamp the clamped object, such as a reaction cup.
  • a circle of protrusions adapted to be held by the gripping hand can be provided on the reaction cup.
  • the first transport component 71 is used for transporting the reaction cup after the sample addition is completed to the transfer position 77 in the first buffer.
  • the first transfer component 71 moves linearly in a first direction, such as the Y direction in the figure, and transports the reaction cup after sample loading to the index 77 in the first buffer. Since the first transfer component 71 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturized design of the sample analysis device.
  • the sample analysis device may also be provided with a sample adding position 10 a, a pre-dilution position 10 b, a first throwing cup position 10 c, and a second throwing cup position 10 d.
  • the first transfer component 71 can move between the sample loading position 10a, the pre-dilution position 10b, the first throwing cup position 10c, and the first buffer indexing position 77 along the first direction, such as the Y direction in the figure.
  • the sample loading position 10a may be the predetermined position where the empty reaction cup is loaded by the reaction cup loading part 10 mentioned above.
  • the sample dispensing part 30 sucks the sample from the sample suction position and discharges it to the sample loading position.
  • the first transfer component 71 first transfers the empty cuvette on the sample loading position 10a to the pre-dilution position 10b, and the sample dispensing component 30 sucks from the sample suction position
  • the samples are discharged side by side into the reaction cup at the pre-dilution position 10b, and then the sample in the reaction cup at the pre-dilution position 10b is diluted; in this process, the reaction cup loading part 10 loads a new empty reaction cup into the sample Position 10a, and then the sample dispensing component 30 sucks the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it to the sample addition position 10a to complete the sample addition; the first transfer component 71 then pre-dilutes The reaction cup on position 10b is tossed, for example, it is transferred to the first toss position 10c for the tossing.
  • the first transfer component 71 only needs to move in the first direction, so the driving component of the first transfer component 71 may be a two-dimensional drive component for driving the first transfer component 71
  • the cup gripper 79 moves along a first direction and a vertical direction, where the first direction can be the Y direction in the figure, and the vertical direction is a direction perpendicular to the paper in the figure.
  • the first transfer member 71 includes a first direction guide 71a, a first direction drive member 71b, a vertical direction guide 71c, and a vertical direction drive member 71d;
  • the guide 71c is slidably provided with the cup gripper 79 of the first transfer component 71, and is driven by the vertical direction guide 71c, so that the cup gripper 79 can move in the vertical direction along the vertical direction guide 71c;
  • the direction guide 71a is slidably provided with a vertical direction guide 71c, and driven by the first direction driving member 71b, the vertical direction guide 71c can move in the first direction along the first direction guide 71a, thereby driving
  • the cup gripper 79 of the first transfer component 71 also moves in the first direction.
  • the cup gripper 79 of the first transfer component 71 can be moved in the first direction and the vertical direction.
  • the first direction guide 71a may include a first guide rail;
  • the first direction driving component 71b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the vertical direction guide 71c may be fixedly connected to the first timing belt; similarly, the vertical direction guide 71c may include a vertical guide rail;
  • the vertical direction drive member 71d may It includes an elevating stepping motor and a vertical screw rod.
  • a mounting plate can be threaded on the vertical screw rod for mounting the cup gripper 79 of the first transfer component 71.
  • the first transfer component 71 may further include a first bracket 71f for installing the above-mentioned first direction guide 71a.
  • the cup gripper 79 of the first transport component 71 grabs, for example, the cuvette on the sample loading position 10a in the second direction, such as the X direction in the figure, so that the first transport component 71 does not grab the cuvette. Affect the sample dispensing part 30 to discharge the sample into the reaction cup, so that the first transfer part 71 can grasp the reaction cup while the sample dispensing part 30 completes the sample addition of the reaction cup, which saves time and improves the measurement speed and measurement speed. effectiveness.
  • the second transfer component 73 is used to transfer the cuvettes indexed 77 in the first buffer to the reaction part 51, and to transfer the reaction cups after the sample incubation in the reaction part 51 is completed to the index 78 in the second buffer.
  • the second transfer component 73 transports the cuvette of the index 77 in the first buffer to the reaction component 51 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. , And transport the reaction cup in which the sample incubation is completed in the reaction part 51 to the index 78 in the second buffer. Since the second transfer member 73 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.
  • the second transfer component 73 can first transport the reaction cup of the first buffer index 77 to the incubation index 51a, and the reagent dispensing part 60 sucks the reagent and discharges it into the reaction cup located in the incubation index 51a. , The second transfer part 73 then transfers the cuvette with the transposition 51a during the incubation to the reaction part 51.
  • the second transfer member 73 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing), so the second The driving part of the transporting part 73 may be a three-dimensional driving part for driving the cup gripper 79 of the second transporting part 73 to move in the first direction, the second direction and the vertical direction.
  • the second transfer member 73 includes a first direction guide 73a, a first direction driving member 73b, a second direction guide 73c, a second direction driving member 73d, and a vertical direction.
  • the vertical direction guide 73e moves in the vertical direction;
  • the second direction guide 73c is slidably provided with a vertical direction guide 73e, and is driven by the second direction driving member 73d, so that the vertical direction guide 73e can move along the first direction.
  • the two-direction guide 73c moves in the second direction, thereby driving the cup gripper 79 of the second transfer member 73 to also move in the second direction;
  • the first-direction guide 73a is slidably provided with a second-direction guide 73c, and Driven by the first-direction driving member 73b, the second-direction guide 73c can move in the first direction along the first-direction guide 73a, thereby driving the second-direction guide 73c to also move in the first direction.
  • the cup gripper 79 of the second transport member 73 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction.
  • the first direction guide 73a may include a first guide rail; the first direction driving component 73b may include a first stepper motor, a first driven wheel, and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 73c can be fixedly connected to the first timing belt; similarly, the second direction guide 73c can include a second guide rail; the second direction drive part 73d can be It includes a second stepping motor, a second driven wheel and a second timing belt. The second timing belt is sleeved between the second stepping motor and the second driven wheel.
  • the vertical direction guide 73e can be fixed to the second timing belt.
  • the vertical direction guide 73e can include a vertical guide rail; the vertical direction driving part 73f can include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The cup gripper 79 is installed on the second transfer component 73.
  • the second transfer component 73 may further include a second bracket 73g for installing the above-mentioned first direction guide 73a.
  • the gripper 79 of the second transfer component 73 grips the cuvette in a second direction, such as the X direction in the figure, so that the second transfer component 71 will not affect the reagent dispensing component 60 when gripping the cuvette.
  • the first reagent dispensing part adds reagents to the reaction cup, so that the second transfer part 73 can grasp the reaction cup while the reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency.
  • the direction in which the second transfer component 73 grabs the reaction cup and the direction of the linear movement of the first set of reagent needles are greater than 90 degrees. In this case, the second transfer component 73 grabs the reaction cup and the first set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.
  • the second transfer component 73 transports the reaction cup from the incubation position 51a to the reaction component 51, and also mixes the sample in the reaction cup. For example, the second transfer component 73 transfers the sample-loaded reaction cup from the first buffer to the transposition 77 and places it in the incubation transposition 51a. The reagent dispensing component 60 then adds reagents to the reaction cup on the transposition 51a in the incubation.
  • the second transfer component 73 picks up the reaction cup with reagents added, mixes it, and then transfers it to the reaction component 51; specifically, the second transfer component 73 can drive the cup gripper 79 through the drive component 71b Shake quickly to achieve mixing of the sample in the reaction cup gripped by the cup gripper 79.
  • the second transfer component 73 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the second transfer component 73 is grabbing Mixing the cuvette when it is ready for transfer also saves time, and there is no need to dispatch the cuvette to the corresponding mixing mechanism for mixing.
  • the second transfer part 73 can and realize the transfer of the cuvette between the first buffer and the incubation part 51a, the reaction part 51 and the second buffer part 78 by linear movement along the first direction and the second direction. .
  • the third transfer part 75 is used to transfer the cuvettes indexed 78 in the second buffer to the measurement part 52.
  • the third transfer component 75 transports the cuvette of the index 78 in the second buffer to the measurement component 52 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. . Since the third transfer member 75 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.
  • the third transfer component 75 may first transport the cuvette of the index 78 in the second buffer to the index 52a in the measurement, and the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette at the index 52a in the measurement. The third transfer part 75 then transfers the cuvette with the index 75 a during the measurement to the measurement part 52. In some embodiments, when the third transfer component 75 transfers the cuvette from the second buffer translocation 78 to the measurement translocation 52a, the third transfer component 75 may not place the cuvette in the measurement translocation 52a, but still grasp it. Take the cuvette.
  • the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette, so that the time for the cuvette to be transposed from the second buffer 78 and finally enter the measuring part 52 is reduced, and the test speed is increased. .
  • the third transfer member 75 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing).
  • the driving part of the transfer part 75 may be a three-dimensional driving part for driving the cup gripper 79 of the third transfer part 75 to move in the first direction, the second direction and the vertical direction.
  • the third transfer member 75 includes a first direction guide 75a, a first direction drive member 75b, a second direction guide 75c, a second direction drive member 75d, and a vertical direction
  • the vertical direction guide member 75e is slidably provided with the cup gripper 79 of the third transfer member 75, and the vertical direction guide member 75f is driven so that the cup gripper 79 can move along
  • the vertical direction guide 75e moves in the vertical direction;
  • the second direction guide 75c is slidably provided with a vertical direction guide 75e, and is driven by the second direction driving member 75d, so that the vertical direction guide 75e can move along the first direction.
  • the two-direction guide 75c moves in the second direction, thereby driving the cup gripper 79 of the third transfer member 75 to also move in the second direction;
  • the first-direction guide 75a is slidably provided with a second-direction guide 75c, and Driven by the first direction driving member 75b, the second direction guide 75c can move in the first direction along the first direction guide 75a, thereby driving the second direction guide 75c to also move in the first direction, so that the second direction guide 75c can also move in the first direction.
  • the cup gripper 79 of the third transport member 75 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction.
  • the first direction guide 75a may include a first guide rail; the first direction driving component 75b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 75c can be fixedly connected to the first timing belt; similarly, the second direction guide 75c can include a second guide rail; the second direction drive member 75d can Including a second stepping motor, a second driven wheel and a second timing belt, the second timing belt is sleeved between the second stepping motor and the second driven wheel, the vertical direction guide 75e can be fixed with the second timing belt Similarly, the vertical direction guide 75e may include a vertical guide rail; the vertical direction driving part 75f may include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The gripper 79 for installing the third transfer component 75. In some embodiments, the third transfer member 75 may further include a
  • the gripper 79 of the third transfer component 75 grips the cuvette in the first direction, such as the Y direction in the figure, so that the third transfer component 75 grasps the cuvette at the same time—even if the third transfer component 75
  • the reaction cup is grasped during the entire reagent addition process, and it will not affect the reagent dispensing part 60, such as the second reagent dispensing part, to add reagents to the reaction cup, so that the third transfer part 75 can grasp the reaction cup at the same time.
  • the reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency.
  • the direction in which the third transfer component 75 grabs the cuvette and the direction of the linear movement of the second set of reagent needles are greater than 90 degrees. In this case, the third transfer component 75 grabs the reaction cup and the second set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.
  • the third transport component 75 mixes the sample in the cuvette during the process of transporting the cuvette from the in-measuring transposition 52a to the measuring component 52. For example, when the third transfer unit 75 transfers the cuvette from the second buffer to the mid-measurement translocation 52a-in some embodiments, the third transfer unit 75 transfers the cuvette to the mid-measurement translocation 52a without dropping the reaction. The cuvette is still grasped underneath; the reagent dispensing part 60 then adds reagents such as the second reagent to the cuvette at 52a during the measurement, and the third transfer part 75 then adds the sample to the cuvette that was grasped.
  • the third transfer part 75 can drive the cup grasping hand 79 to shake quickly through the driving part 71b to realize the test in the reaction cup grasped by the cup grasping hand 79. Mix the same.
  • the third transfer component 75 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the third transfer component 75 For example, the transposition 52a is used to mix the reaction cup on the transport path in the measurement, which also saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
  • the third transfer component 75 can also grab the measured reaction cup in the measurement component 52, and then transfer it to the second throwing cup position 10d for cup throwing.
  • the second cup throwing position 10d can be arranged near the index 78 in the second buffer, or between the measuring part 52 and the index 78 in the second buffer, so that the third transfer part 75 moves from the measuring part 52 to the index 78.
  • the index 78 in the second buffer is used to transfer the cuvette on the index 78 in the second buffer, the measured cuvette on the measuring component 52 can be thrown away by the way, thereby saving time and improving test efficiency.
  • the third transfer part 75 can and realize the transfer of the reaction cup between the second buffer 78, the measurement 52a, the measurement part 52 and even the second throwing position 10d by linear movement in the first direction and the second direction. .
  • the above is the description of the scheduling component 70 of some embodiments of the present invention.
  • the application uses three transport components, namely the first transport component 71, the second transport component 73 and the third transport component 75 to complete the rapid transport of the cuvette.
  • the scheduling path is simple and direct, which is conducive to the speed-up of the sample analysis device; in conjunction with the two buffer transfer positions, namely the first buffer transfer position 77 and the second buffer transfer position 78, the transition between the three transfer components is completed, and the structure is also Simple and compact.
  • sample analysis device disclosed in some embodiments of the present invention. It is understandable that the sample analysis device disclosed in the present invention may also include some other structures, such as the cleaning component 80 and/or the processor 90, etc., which will be specifically described below with reference to FIG. 15 and FIG. 16.
  • the cleaning component 80 is used for cleaning the reagent needles, for example, cleaning the first reagent needle and the second reagent needle.
  • the cleaning component 80 may include multiple cleaning tanks 81, and the number of cleaning tanks 81 may be the same as the number of reagent needles.
  • the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component
  • each reagent When the dispensing parts both include two reagent needles, the number of cleaning tanks can be four.
  • a washing tank can be set on the linear movement track of each reagent needle for cleaning the reagent needle. Referring to FIG. 16, the cleaning component 80 is used to clean the reagent needle.
  • the inner wall and the outer wall of the reagent needle may be cleaned by a cleaning solution.
  • the cleaning component 80 includes a cleaning tank, a pipeline, an on-off valve arranged on the pipeline, and the like in the figure.
  • the end of the reagent needle can be connected to a pipeline, which is opened and closed by the on-off valve SV01.
  • the on-off valve SV01 When the on-off valve SV01 is opened, the cleaning fluid can reach the end of the reagent needle through the pipeline, flow through the inner wall of the reagent needle, and from The front end of the reagent needle flows out to complete the cleaning of the inner wall of the reagent needle by the cleaning solution.
  • the cleaning chamber is also connected to a pipeline, which is opened and closed by the on-off valve SV02.
  • the cleaning fluid can reach the cleaning chamber through the pipeline, and spray from the cleaning chamber wall to the outer wall of the reagent needle. Finish cleaning the outer wall of the reagent needle with the cleaning solution.
  • the lower end of the cleaning chamber is connected to a waste liquid suction valve SV03 through a pipeline.
  • the waste liquid suction valve SV03 is opened, the cleaned waste liquid flows out through the lower end of the cleaning chamber.
  • the reagent needle comes to the top of the cleaning chamber, and then moves downward to extend the part of the reagent needle (at least the part of the needle that touches the reagent liquid surface when sucking the reagent) into the cleaning chamber, so that the cleaning chamber sprays.
  • the cleaning solution can be used to clean the part of the needle body where the reagent needle touches the liquid surface to complete the cleaning of the reagent needle.
  • Each cleaning tank 81 can share the same set of liquid paths to provide cleaning liquid for cleaning the reagent needles.
  • the sample analysis device in some embodiments may work in this way.
  • the cuvette loading part 10 supplies and carries empty cuvettes.
  • the cuvette loading part 10 may load an empty cuvette to a predetermined position, and the predetermined position may be used as a sample loading position.
  • the sample component 20, such as the sample injection component 21, dispatches the sample rack carrying the sample to the sample suction position.
  • the sample dispensing component 30 draws samples from the sample suction position and dispenses them into the reaction cup.
  • the sample dispensing component draws samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.
  • the driving part of the reagent carrying part 60 drives the reagent carrying part 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing part 60 sucks the first reagent in the reagent container through the first reagent suction position, and is indexed in the first reagent suction position and the reagent addition of the reaction part 51 A linear motion is made between them to dispense the first reagent into the reaction cup indexed in the reagent addition of the reaction part 51.
  • the transposition in the reagent addition of the reaction part 51 may be the transposition 51a in the incubation mentioned herein.
  • the two first reagent needles 61 of the first reagent dispensing part 60 independently move linearly between the first reagent suction position and the reagent adding position of the reaction part 51.
  • the two first reagent needles 61 of the first reagent dispensing part 60 can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part 51, which improves Improve the test speed and efficiency.
  • each first reagent needle 61 in the first reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the first reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence.
  • the two reagent needles 61 of the first reagent dispensing part 60 can avoid occupying public resources as much as possible, so that the number of parts providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged.
  • the action sequence of the first reagent needle 61 also avoids their mutual influence as much as possible, which is very beneficial to the speed-up of the sample analysis device.
  • the scheduling component 70 schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component 51 for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measuring component 52 for indexing.
  • the mid-reagent transposition of the measuring part 52 may be the mid-measure transposition 52a mentioned herein.
  • the reagent carrying member 40 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing part 60 sucks the second reagent in the reagent container through the second reagent suction position, and acts between the second reagent suction position and the reagent adding position of the measuring part. It moves linearly to dispense the second reagent into the reaction cup indexed in the reagent addition of the measuring part 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing part 60 independently move linearly between the second reagent suction position and the indexing position of the measuring part 52 during reagent addition.
  • each second reagent needle 61 in the second reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence.
  • the two reagent needles 61 of the second reagent dispensing part 60 can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged.
  • the action timing of the second reagent needle also minimizes their mutual influence, which is very beneficial to the speed-up of the sample analysis device.
  • the scheduling component 70 schedules the reaction cup that has completed the dispensing of the second reagent to the measurement component 52 for item detection, and schedules the reaction cup after the detection to the waste recovery device—for example, the second throwing cup position mentioned herein.
  • sample analysis method includes the following steps:
  • Step 100 controls the supply of the reaction cup loading parts and carries the empty reaction cup.
  • the cuvette loading part can load an empty cuvette to a predetermined position, and the predetermined position can be used as a sample loading position.
  • Step 110 controls the sample component, such as the sample injection component, to dispatch the sample rack carrying the sample to the sample suction position.
  • step 120 the sample dispensing step, the sample dispensing component is controlled to draw a sample from the sample suction position and dispense it into the reaction cup.
  • the sample dispensing component sucks samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.
  • step 130 the first reagent dispensing step
  • the driving part of the reagent carrying part is controlled to drive the reagent carrying part to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position;
  • At least one of the two reagent needles sucks the first reagent in the reagent container through the first reagent sucking position, and moves linearly between the first reagent sucking position and the indexing position of the reagent in the reaction part to add to the reaction part.
  • the transposed reaction cup among the reagents dispenses the first reagent.
  • the translocation in the reagent addition of the reaction component in step 130 may be the translocation in the incubation mentioned herein.
  • step 130 controls the two first reagent needles of the first reagent dispensing part to move linearly between the first reagent suction position and the reagent adding position of the reaction part independently of each other.
  • the two first reagent needles of the first reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part, which improves the test speed And efficiency.
  • step 130 controls each first reagent needle in the first reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the two first reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence.
  • the two reagent needles of the first reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two first reagent needles can be arranged.
  • the action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device.
  • the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between the two first reagent needles, at least one of the four actions does not overlap in time sequence.
  • Step 130 completes adding the first reagent to the reaction cup with the sample.
  • Step 140 that is, the incubation step, the control scheduling component schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measurement component for indexing.
  • the transposition in the reagent addition of the measurement component may be the transposition in the measurement mentioned herein.
  • Step 150 that is, the second reagent dispensing step, control the rotation of the reagent carrying part so that the reagent container carrying the second reagent is located at the second reagent suction position; control at least one of the two reagent needles on the second reagent dispensing part A second reagent in the reagent container is sucked through the second reagent suction position, and a linear motion is made between the second reagent suction position and the indexing position of the reagent adding of the measuring part, so as to divide the reaction cup indexed into the reagent adding of the measuring part. Inject the second reagent.
  • step 150 controls the two second reagent needles of the second reagent dispensing part to move linearly between the second reagent suction position and the reagent adding position of the measuring part independently of each other.
  • the two second reagent needles of the second reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the second reagent to the reaction cup on the transposition in the reagent addition of the measuring part, which improves the test speed And efficiency.
  • step 150 controls each second reagent needle in the second reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence.
  • the two reagent needles of the second reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two second reagent needles can be arranged.
  • the action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device.
  • the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between two second reagent needles, at least one of the four actions does not overlap in time sequence.
  • Step 150 is completed to continue adding the second reagent to the reaction cup carrying the reagent after the incubation.
  • Step 160 that is, the measurement and recovery step
  • the control and scheduling component will dispatch the reaction cup that has completed the dispensing of the second reagent to the measurement component for item detection, and dispatch the completed reaction cup to the waste recovery device-the waste recovery device can It has, for example, the second tossing position mentioned in this article.
  • the work flow arrangement of the reagent dispensing component 60 puts forward important constraints on the completion of the detection speed, and each reagent needle needs to complete actions such as sample aspiration, heating, layout, and cleaning.
  • the reagent carrying member 40 is used to ensure the activity of the reagent, and the temperature is generally lower, for example, below 16°C. After the reagent is taken out from the reagent carrying member 40, it needs to be heated in the reagent needle to about 37° C. in a short time to ensure a sufficient reaction process. Normally, the heating time of the reagent drawn by the reagent needle by the heating part of the reagent needle requires 4-10 seconds.
  • the reagent needle needs to absorb different types of reagents in the detection process of different test items.
  • the trigger reagent is added to the reaction cup to react. Therefore, the same reagent needle needs to be cleaned by ordinary cleaning or strong cleaning when sucking reagents from different items.
  • the cleaning time generally takes 2 to 8 seconds.
  • the sample suction and layout actions generally take 1.5 to 3 seconds (including the time for the horizontal movement to reach the position). Therefore, for a sample analysis device, for example, a single working cycle is 8 seconds, and it is difficult to complete all the actions of aspirating, heating, setting out, and cleaning in one working cycle, and the overall detection speed is nearly reduced.
  • the processor 90 is used to control each reagent needle in the same group to perform multiple preset actions in sequence, such as a reagent suction action, a reagent heating action in the reagent needle, a reagent discharge action, and a reagent needle cleaning action to complete Reagent adding operation, and at least one corresponding preset action among the multiple preset actions between two reagent needles in the same group does not overlap in time sequence.
  • the first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles, and at least one of the corresponding preset actions between the two first reagent needles does not overlap in time sequence.
  • the second set of reagent needles in the reagent dispensing component 60 includes two second reagent needles, and at least one corresponding preset action between the two second reagent needles does not overlap in time sequence.
  • the ping-pong mode may be set for the sample analysis device. When this mode is enabled, the processor 90 executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles is in time sequence. No overlap, for example, in the same group of reagent needles, at least one corresponding action does not overlap in time sequence of the reagent sucking action, the reagent heating action in the reagent needle, the reagent discharging action, and the reagent needle cleaning action.
  • the corresponding actions include a reagent sucking action and/or a reagent needle cleaning action.
  • the processor will control each reagent to perform multiple preset actions in sequence to complete Reagent adding operation, and at least one corresponding preset action among the plurality of preset actions between two reagent needles does not overlap in time sequence.
  • the first reagent needle includes a first reagent needle a1 and a first reagent needle a2
  • the second reagent needle includes a second reagent needle b1 and a second reagent needle b2.
  • the processor controls the first reagent needle a1, the first reagent needle a2, the second reagent needle b1, and the second reagent needle b2 to each complete multiple preset actions, at least one corresponding preset action does not overlap in time sequence.
  • the processor arranges all the reagent needles in the sample analysis device in time sequence to prevent the actions of the reagent needles from interfering with each other to grab resources, thereby more effectively using shared resources and improving the sample testing efficiency of the sample analysis device.
  • the aforementioned multiple preset actions may include a first type of preset action and a second type of preset action.
  • the first type of preset action is the action that each reagent needle needs to interact with the same component.
  • the first type of preset action can be some actions that the reagent needle needs to occupy public resources, such as the action of sucking reagent-which needs to occupy the reagent load.
  • the common part of the component 40 such as the reagent needle cleaning action, needs to occupy a pipeline for providing the cleaning liquid for each cleaning tank 81; therefore, the first type of preset actions include at least a reagent suction action and a reagent needle cleaning action.
  • the second type of preset actions are actions in which each reagent does not need to interact with the same component.
  • the second type of preset actions can be actions that do not require common resources for reagent needles, such as reagent heating actions-each reagent needle Each heating component heats the sucked reagent; therefore, the second type of preset action includes at least the heating action of the reagent in the reagent needle.
  • the first type of preset actions corresponding to the two reagent needles in the same group do not overlap in time sequence, for example, the reagent sucking action between two reagent needles in the same group does not overlap in time sequence.
  • the cleaning action of the reagent needle does not overlap in time sequence.
  • Figure 18 is an example.
  • each corresponding preset action in the plurality of preset actions between two reagent needles in the same group does not overlap in time sequence.
  • Figure 19 is an example.
  • the first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles.
  • the reagent suction action between the two first reagent needles does not overlap in time sequence, and the reagent heating action in the reagent needle is in time sequence. No overlap, the sequence of the ejection of reagents does not overlap, and the sequence of the reagent needle cleaning action does not overlap the reagent sucking action; for another example, the second group of reagent needles in the second reagent dispensing part 60 includes two second reagents.
  • the reagent suction action between the two second reagent needles does not overlap in time sequence
  • the reagent heating action in the reagent needle does not overlap in time sequence
  • the reagent ejection action does not overlap in time sequence
  • the reagent needle cleaning action sucks The reagent actions do not overlap in timing.
  • the time interval between two adjacent and identical test items outputting results is defined as a cycle, and the number of reagent needles set in each reagent dispensing component is equal to that of one reagent needle.
  • the number of cycles occupied by multiple preset actions is equal. For example, the number of cycles occupied by one reagent needle to complete the above-mentioned multiple preset actions (for example, reagent suction action, reagent heating action in the reagent needle, reagent discharge action, and reagent needle cleaning action) is two, then two reagent dispensing components are set One reagent needle, or the number of reagent needles in the same group is two.
  • the processor 90 controls each reagent needle of the reagent dispensing component to complete the multiple preset actions within a preset time (for example, a reagent sucking action, a reagent heating action in the reagent needle, Reagent discharging action and reagent needle cleaning action), the preset time is equal to N times the period, and N is equal to the number of reagent needles of the reagent dispensing part. For example, if the number of reagent needles in each reagent dispensing part 60 is two, then N is equal to two.
  • Each reagent needle needs to complete the multiple preset actions (for example, reagent sucking action, reagent needle Reagent heating action, reagent discharge action and reagent needle cleaning action).
  • the test speed of the sample analysis device can be equivalent to that each reagent needle completes the multiple in one cycle.
  • Preset actions (such as sucking reagent, heating reagent in the reagent needle, discharging reagent, and cleaning reagent needle) ensure a constant output speed of the sample analysis device. There is a preset time mentioned here.
  • the preset time includes action time and waiting time, where the action time is used to perform the above-mentioned preset actions (for example, the action of sucking reagent, the action of heating the reagent in the reagent needle, the action of discharging the reagent, and the action of cleaning the reagent needle)
  • the action time is less than or equal to the preset time.
  • the waiting time is divided into one or more periods of time, and is inserted between the plurality of preset actions and/or after the last preset action in time sequence—for example, it is inserted in time sequence Between the reagent suction action, the reagent heating action in the reagent needle, the reagent discharging action and the reagent needle cleaning action and/or after the reagent needle cleaning action; for example, FIG. 20 is an example.
  • the waiting time is divided into one or more periods, and at least one period in the sequence is used as an additional action time for performing a preset action. In this way, the preset action can have extra time to continue to execute.
  • the execution time of the preset action is prolonged, which can make the reagent needle have more stable performance, such as the action of sucking reagent and
  • the execution time of the reagent ejection action has been prolonged, which can make the reagent needle suck and eject the reagent more stably, and it is not easy to cause abnormal conditions such as empty suction or collision with the reaction cup.
  • the execution time of the reagent heating action in the reagent needle is reduced
  • the extension can make the reagents in the reagents be fully preheated; for another example, the execution time of the reagent needle cleaning action is prolonged, which can make the reagent needles cleaned more fully, and it is not easy to cause cross-contamination of the next test item. Improve the accuracy of test results. Therefore, in some embodiments, the sample analysis device may include a full heating mode. When the full heating mode is activated, the processor 90 executes the full heating mode so that the waiting time is divided into one or more periods, and At least one period in the sequence is used as an additional action time for executing the reagent heating action in the reagent needle.
  • Figure 21 is an example.
  • the heating action in the figure refers to the heating action of the reagent in the reagent needle in this article
  • the cleaning action refers to the cleaning action of the reagent needle in this article
  • Figures 18 to 21 are drawn
  • the two reagent needles refer to the two reagent needles in the same group, for example, the two first reagent needles in the first group of reagent needles, or the two second reagent needles in the second group of reagent needles.
  • the action sequence of the reagent needle is designed.
  • the introduced reagent dispensing component has, for example, two reagent needles arranged in parallel.
  • the double reagent needles running independently and linearly are scheduled through ping-pong, and the extended cycle completes reagent suction, preheating, and reagent discharge.
  • the entire workflow of cleaning and cleaning provides double resources to ensure speed increase, so as to achieve the goal of no slowdown in testing of multiple inspection items.
  • the present invention uses three transfer components and two buffer transfers to transfer the cuvette.
  • Some embodiments of the present invention also disclose a method of a sample analysis device. Please refer to FIG. 22.
  • the method may include the following steps:
  • step 200 the first transfer component is controlled to transport the reaction cup after sample addition to the first buffer for transposition.
  • step 200 controls the first transport component to move linearly in the first direction, and transport the reaction cup after sample addition to the first buffer for indexing.
  • Step 210 Control the second transport component to transport the transposed cuvette in the first buffer to the incubation position.
  • the incubation position here may be a reaction cup placement position in the reaction component 51.
  • step 210 controls the second transport member to transport the transposed cuvette in the first buffer to the incubation position through linear movement in the first direction and linear movement in the second direction.
  • step 220 the second transport component is controlled to transport the reaction cup that has completed the sample incubation in the incubation position to the second buffer for transposition.
  • step 220 controls the second transport component to transport the reaction cups completed with the sample in the incubation position to the second buffer for transposition through linear motion in the first direction and linear motion in the second direction. In some specific embodiments, step 220 controls the second transport component to first transport the cuvettes transposed in the first buffer to the incubation for adding reagents, and then transport the cuvettes translocated and added reagents during the incubation to the incubation. Bit.
  • step 220 during the transposition and transportation of the reaction cup from the incubation to the incubation position, the second transfer component is controlled to mix the sample in the reaction cup.
  • the second transfer component transfers the reaction cup, the second transfer component is also controlled to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
  • Step 230 Control the third transport component to transport the indexed cuvette in the second buffer to the measurement position.
  • step 230 controls the third transport component to transport the indexed cuvette in the second buffer to the measurement position through linear movement in the first direction and linear movement in the second direction. In some specific embodiments, step 230 controls the second transport component to first transport the cuvettes indexed in the second buffer to the assay for adding reagents, and then transport the cuvettes after the indexing and adding reagents during the assay to the assay. Bit.
  • step 230 controls the third transfer component to mix the sample in the reaction cup during the transposition and transportation of the reaction cup from the second buffer to the measurement position.
  • the third transfer component transfers the reaction cup, it also controls the third transfer component to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
  • the three transport components move along a straight line to realize the rapid transport of the reaction cup.
  • the scheduling path of the reaction cup is simple and direct, which is beneficial to the speed-up of the sample analysis device.
  • the reaction component 51 has a certain number of reaction cup placement positions, and can heat the sample in the reaction cup located on the reaction cup placement position to incubate the sample.
  • some test items may need to add a first reagent, such as a mixed reagent.
  • the first reagent dispensing part 60 sucks the first reagent, for example, mixed reagents, from the reagent carrying part 40, and discharges the sucked first reagent into the reaction part 51
  • the reaction cup of 51a is transposed to complete the mixing of the first reagent and the sample.
  • the second transfer part 73 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the reaction part 51, and the reaction part 51 incubates the reaction solution or sample in the reaction cup .
  • the reagent carrying member 40 is to ensure the activity of the reagent, so the working temperature is usually low, for example, usually below 16°C.
  • the first reagent needs to be heated to about 37°C before being added to the reaction cup and mixed with the sample.
  • the two first reagent needles 61 of the first reagent dispensing part 60 have heating parts for completing the reagent heating function .
  • the heating time for the reagents requires 4-10 seconds.
  • the single working cycle is, for example, 8 seconds.
  • the first reagent dispensing part 60 has two first reagent needles 61, and the two first reagent needles 61 respectively suck the first reagent, such as mixed reagent, from the reagent carrying part 40, and are fixed in The linear guide on the linear beam moves to the incubation position 51a, and the first reagent, such as mixed reagent, is added to the reaction cup in turn.
  • the two first reagent needles 61 are arranged in parallel and move independently.
  • the working cycle time of the first reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the first reagent.
  • the reaction cup After the sample in the reaction cup is heated and incubated in the reaction part 51 for a fixed period of time, the reaction cup is transferred to the measurement part 52 through the cooperation of the second transfer part 73 and the third transfer part 75. In some embodiments, the measurement can be carried out on the way.
  • the intermediate position 52a is used to add a second reagent such as a trigger reagent.
  • the third transfer part 75 transfers the cuvette to the measuring transposition 52a, and the second reagent dispensing part 60 sucks the second reagent, such as the trigger reagent, from the reagent carrying part 40, and moves it to the cuvette gripped by the third transfer part 75.
  • a second reagent such as a trigger reagent is added to the reaction cup to complete the mixing of the second reagent and the sample.
  • the third transfer component 75 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the measurement component 52 to perform coagulation signal analysis and detection to obtain the detection result.
  • the second reagent dispensing part 60 Similar to the first reagent dispensing part 60, in order to ensure sufficient heating time for the second reagent, such as the trigger reagent, the second reagent dispensing part 60 also has two reagent needles, such as two second reagent needles; The two reagent needles respectively suck the second reagent, such as trigger reagent, from the reagent carrying member 40, move to the measuring index 52a through the linear guide rail fixed on the linear beam, and add the second reagent, such as trigger reagent, to the reaction cup in turn.
  • the two second reagent needles 61 are arranged in parallel and move independently.
  • the working cycle time of the second reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the second reagent.
  • the reaction cup in the measuring part 52 is irradiated with multi-wavelength light, and the transmitted light or scattered light is received by, for example, a photodetector in the measuring part 52, and a detection signal corresponding to the amount of received light is output.
  • the detection signal can be sent to, for example, processing
  • the device 90 is used for data analysis, processing and generation of corresponding display content.
  • Sample analysis devices such as automatic coagulation analyzers can use different methods such as coagulation method, immunoturbidimetric method, and chromogenic substrate method for sample analysis.
  • the measuring part 52 irradiates the reaction cup with different wavelengths.
  • the wavelength range can be, for example, between 405 nm and 800 nm.
  • the reaction cup that has completed the test can be transferred to the waste recycling device by the third transfer component 75-the waste recycling device can have, for example, the second throwing cup position mentioned herein, and the third transfer component 75 discards the reaction cup to the second throwing cup In the position, the disposal of the reaction cup is completed.
  • any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD to ROM, DVD, Blu Ray disks, etc.), flash memory and/or the like .
  • These computer program instructions can be loaded on a general-purpose computer, a special-purpose computer or other programmable data processing equipment to form a machine, so that these instructions executed on the computer or other programmable data processing equipment can generate a device that realizes the specified functions.
  • These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing equipment to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a piece of Manufactured products, including realizing devices that realize designated functions.
  • Computer program instructions can also be loaded on a computer or other programmable data processing equipment, so as to execute a series of operation steps on the computer or other programmable equipment to produce a computer-implemented process, so that the execution on the computer or other programmable equipment Instructions can provide steps for implementing specified functions.
  • Coupled refers to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection and/or any other connection.

Abstract

A sample analyzing apparatus, in which a reagent dispensing component (60) has reagent needles (61); the reagent needles (61) are arranged in a manner that the reagent needles can move independently of each other; each processing unit (50) is provided with a set of reagent needles (61); the reagent needle (61) is used to suck a reagent from a reagent carrying component (40) and discharge the reagent to a reaction cup of the corresponding processing unit (50), and each set of reagent needles (61) comprises at least two reagent needles (61). Each reagent needle (61) implements multiple preset actions in sequence to complete a reagent adding operation, and at least one pair of corresponding preset actions among the multiple preset actions of two reagent needles (61) does not overlap in timing.

Description

一种样本分析装置Sample analysis device 技术领域Technical field
本发明涉及一种样本分析装置。The invention relates to a sample analysis device.
背景技术Background technique
样本分析装置,例如生化分析仪、免疫分析仪、凝血分析仪和细胞分析仪等,是用于分析和测定样本的仪器,一般都是通过向样本中加入试剂,对与试剂反应后的样本通过一定的方式来测得样本本身的特性、化学成分以及浓度等。Sample analysis devices, such as biochemical analyzers, immunoassay analyzers, coagulation analyzers, and cell analyzers, are instruments used to analyze and determine samples. Generally, reagents are added to the sample to pass the sample after reacting with the reagent. A certain way to measure the characteristics, chemical composition and concentration of the sample itself.
为了实现样本分析装置的自动化测试,一个核心在于将复杂的测量过程分解为连续的可重复的测量周期,每个周期内各部件完成预定的一个或多个动作,再通过不同测量周期的组合来实现不同的测量流程。In order to realize the automated test of the sample analysis device, one of the cores is to decompose the complex measurement process into continuous and repeatable measurement cycles. In each cycle, each component completes one or more predetermined actions, and then through the combination of different measurement cycles Realize different measurement processes.
随着样本测试量的不断增加,用户希望可以获得测试速度更快的样本分析装置,提高样本分析装置对于样本的处理能力,从而降低测试时间,更迅速地得到检测结果。测试速度提升的关键,是使得测量周期时间尽量缩短,也就是要在尽量短的时间内确保仪器各部件都可以完成预定的全部测量所需的工作。With the continuous increase of the sample test volume, users hope to obtain a sample analysis device with a faster test speed, improve the sample processing capacity of the sample analysis device, thereby reducing the test time and obtaining the test results more quickly. The key to improving the test speed is to shorten the measurement cycle time as much as possible, that is, to ensure that all parts of the instrument can complete all the tasks required for the scheduled measurement in the shortest possible time.
试剂加样分注过程作为测量流程中的关键环节,如何满足短时间周期内完成全部所需动作是样本分析装置测试速度提升的关键。如何解决越来越短的测量周期和纷繁复杂动作占用时长的矛盾是本发明所要研究的。The reagent adding and dispensing process is a key link in the measurement process. How to complete all required actions in a short period of time is the key to improving the test speed of the sample analysis device. How to solve the contradiction between the shorter and shorter measurement period and the time occupied by complicated actions is the research of the present invention.
发明概述Summary of the invention
技术问题technical problem
本发明主要提供一种样本分析装置,下面具体说明。The present invention mainly provides a sample analysis device, which will be described in detail below.
问题的解决方案The solution to the problem
技术解决方案Technical solutions
根据第一方面,一种实施例中提供一种样本分析装置,包括:According to the first aspect, an embodiment provides a sample analysis device, including:
反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
试剂承载部件,具有多个用于承载试剂容器的位置;The reagent carrying component has a plurality of positions for carrying reagent containers;
一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;One or more processing units; the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
试剂分注部件,具有试剂针;各试剂针以能够互相独立运动的方式所设置;其中每一所述处理单元都被配置有一组所述试剂针;所述试剂针用于从试剂承载部件吸取试剂并排放到相应的处理单元的反应杯中,且每组试剂针至少包括两根试剂针;The reagent dispensing part has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a set of the reagent needles; the reagent needles are used to suck from the reagent carrying part The reagents are discharged into the reaction cup of the corresponding processing unit, and each group of reagent needles includes at least two reagent needles;
清洗部件,用于清洗试剂针;Cleaning parts, used to clean reagent needles;
以及as well as
处理器;所述处理器用于控制同一组内每根试剂针都依次进行多个预设动作以完成加试剂操作,并且同一组内两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。Processor; the processor is used to control each reagent needle in the same group to sequentially perform multiple preset actions to complete the reagent adding operation, and at least among the multiple preset actions between two reagent needles in the same group There is a corresponding preset action that does not overlap in timing.
根据第二方面,一种实施例中提供一种样本分析装置,包括:According to a second aspect, an embodiment provides a sample analysis device, including:
反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
试剂承载部件,所述试剂承载部件呈圆盘状结构设置,并具有多个用于承载试剂容器的位置,所述试剂承载部件能够转动并带动其承载的试剂容器转动,用于将试剂容器转动到吸试剂位;A reagent carrying component, the reagent carrying component is arranged in a disc-shaped structure and has a plurality of positions for carrying reagent containers, the reagent carrying component can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container To the suction position;
一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;其中各处理单元都配置有相应的加试剂中转位;以及One or more processing units; the processing unit is used to receive the cuvette carrying the sample dispatched by the scheduling component, and process the sample in the cuvette; wherein each processing unit is equipped with a corresponding reagent addition relay Bit; and
试剂分注部件,具有试剂针;所述试剂针用于从吸试剂位吸取试剂并排放到位于加试剂中转位的反应杯中;其中每处加试剂中转位都被配置有一组所述试剂针,每组试剂针至少包括两根试剂针,所述试剂针被以在所述吸试剂位和对应的加试剂中转位之间独立地沿直线运动的方式所设置;The reagent dispensing component has a reagent needle; the reagent needle is used to suck reagent from the reagent suction position and discharge it into the reaction cup positioned in the reagent adding; wherein each position in the reagent adding is configured with a set of the reagent needles Each group of reagent needles includes at least two reagent needles, and the reagent needles are arranged in a manner of independently moving in a straight line between the reagent suction position and the corresponding reagent adding position;
多个清洗池,分别设置于各试剂针的直线运动的轨迹上,用于对试剂针进行清洗;以及A plurality of washing tanks are respectively arranged on the track of the linear movement of each reagent needle for cleaning the reagent needle; and
处理器;所述处理器用于控制每根试剂针都依次进行吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作以完成加试剂操作;所述样本分析装置包括乒乓模式,所述处理器执行所述乒乓模式,以使得每组试剂针中的两两试剂针之间的至少一个对应动作在时序上不交叠。The processor; the processor is used to control each reagent needle to sequentially perform a reagent suction action, a reagent heating action in the reagent needle, a reagent ejection action, and a reagent needle cleaning action to complete the reagent addition operation; the sample analysis device includes a ping-pong mode, The processor executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles does not overlap in time sequence.
根据第三方面,一种实施例中提供一种样本分析装置,包括:According to a third aspect, an embodiment provides a sample analysis device, including:
反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
试剂承载部件,具有多个用于承载试剂容器的位置;The reagent carrying component has a plurality of positions for carrying reagent containers;
一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;One or more processing units; the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
试剂分注部件,具有试剂针;各试剂针以能够互相独立运动的方式所设置;其中每一所述处理单元都被配置有一组所述试剂针;所述试剂针用于从试剂承载部件吸取试剂并排放到相应的处理单元的反应杯中,且每组试剂针至少包括两根试剂针;The reagent dispensing part has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a set of the reagent needles; the reagent needles are used to suck from the reagent carrying part The reagents are discharged into the reaction cup of the corresponding processing unit, and each group of reagent needles includes at least two reagent needles;
清洗部件,用于清洗试剂针;Cleaning parts, used to clean reagent needles;
以及as well as
处理器;所述处理器用于控制每根试剂都依次进行多个预设动作以完成加试剂操作,并且两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。Processor; the processor is used to control each reagent to sequentially perform multiple preset actions to complete the reagent adding operation, and at least one of the multiple preset actions between the two reagent needles has a corresponding preset action There is no overlap in timing.
发明的有益效果The beneficial effects of the invention
对附图的简要说明Brief description of the drawings
附图说明Description of the drawings
图1为一种实施例的样本分析装置的结构示意图;FIG. 1 is a schematic structural diagram of a sample analysis device according to an embodiment;
图2为另一种实施例的样本分析装置的结构示意图;FIG. 2 is a schematic structural diagram of a sample analysis device of another embodiment;
图3为又一种实施例的样本分析装置的结构示意图;FIG. 3 is a schematic structural diagram of a sample analysis device according to another embodiment;
图4(a)和图4(b)为两种实施例的试剂承载部件的结构示意图;4(a) and 4(b) are schematic diagrams of the structure of the reagent carrying member of two embodiments;
图5为另一种实施例的试剂承载部件的结构示意图;FIG. 5 is a schematic diagram of the structure of a reagent carrying member according to another embodiment;
图6为还一种实施例的样本分析装置的结构示意图;FIG. 6 is a schematic structural diagram of a sample analysis device according to another embodiment;
图7为一种实施例的试剂分注部件的结构示意图;FIG. 7 is a schematic structural diagram of a reagent dispensing component of an embodiment;
图8为另一种实施例的试剂分注部件的结构示意图;Fig. 8 is a schematic structural diagram of a reagent dispensing component of another embodiment;
图9为又一种实施例的试剂分注部件的结构示意图;FIG. 9 is a schematic structural diagram of a reagent dispensing component according to another embodiment;
图10为还一种实施例的试剂分注部件的结构示意图。Fig. 10 is a schematic diagram of the structure of a reagent dispensing component according to another embodiment.
图11为再一种实施例的样本分析装置的结构示意图;FIG. 11 is a schematic structural diagram of a sample analysis device according to another embodiment;
图12(a)为一种实施例的转运部件的结构示意图,图12(b)为一种实施例的第一转运部件的结构示意图,图12(c)为一种实施例的第二转运部件的结构示意图,图12(d)为一种实施例的第三转运部件的结构示意图;Figure 12 (a) is a schematic structural diagram of a transport component of an embodiment, Figure 12 (b) is a schematic structural diagram of a first transport component of an embodiment, and Figure 12 (c) is a second transport component of an embodiment Schematic diagram of the structure of the component, FIG. 12(d) is a schematic diagram of the structure of the third transport component of an embodiment;
图13为一种实施例的抓杯手的结构示意图;Figure 13 is a schematic structural diagram of an embodiment of a cup grasping hand;
图14为还另一种实施例的样本分析装置的结构示意图;FIG. 14 is a schematic structural diagram of a sample analysis device according to still another embodiment;
图15为又另一种实施例的样本分析装置的结构示意图;FIG. 15 is a schematic structural diagram of a sample analysis device according to still another embodiment;
图16为一种实施例的清洗部件的结构示意图;Figure 16 is a schematic structural diagram of a cleaning component of an embodiment;
图17为一种实施例的样本分析方法的流程示意图;FIG. 17 is a schematic flowchart of a sample analysis method according to an embodiment;
图18为一种实施例的同一组的两试剂针的时序动作图;18 is a time sequence diagram of two reagent needles in the same group according to an embodiment;
图19为又一种实施例的同一组的两试剂针的时序动作图;FIG. 19 is a time sequence diagram of two reagent needles in the same group according to another embodiment;
图20为还一种实施例的同一组的两试剂针的时序动作图;FIG. 20 is a time sequence diagram of two reagent needles in the same group according to another embodiment;
图21为再一种实施例的同一组的两试剂针的时序动作图;FIG. 21 is a time sequence diagram of two reagent needles in the same group according to another embodiment;
图22为一种实施例的样本分析装置的方法。Fig. 22 shows a method of a sample analysis device according to an embodiment.
发明实施例Invention embodiment
本发明的实施方式Embodiments of the present invention
下面通过具体实施方式结合附图对本发明作进一步详细说明。其中不同实施方式中类似元件采用了相关联的类似的元件标号。在以下的实施方式中,很多细节描述是为了使得本发明能被更好的理解。然而,本领域技术人员可以毫不费力的认识到,其中部分特征在不同情况下是可以省略的,或者可以由其他元件 、材料、方法所替代。在某些情况下,本发明相关的一些操作并没有在说明书中显示或者描述,这是为了避免本发明的核心部分被过多的描述所淹没,而对于本领域技术人员而言,详细描述这些相关操作并不是必要的,他们根据说明书中的描述以及本领域的一般技术知识即可完整了解相关操作。Hereinafter, the present invention will be further described in detail through specific embodiments in conjunction with the accompanying drawings. Among them, similar elements in different embodiments use related similar element numbers. In the following embodiments, many detailed descriptions are used to enable the present invention to be better understood. However, those skilled in the art can easily realize that some of the features can be omitted under different circumstances, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the present invention are not shown or described in the specification. This is to prevent the core part of the present invention from being overwhelmed by excessive descriptions. For those skilled in the art, these are described in detail. Related operations are not necessary, they can fully understand the related operations based on the description in the manual and the general technical knowledge in the field.
另外,说明书中所描述的特点、操作或者特征可以以任意适当的方式结合形成各种实施方式。同时,方法描述中的各步骤或者动作也可以按照本领域技术人员所能显而易见的方式进行顺序调换或调整。因此,说明书和附图中的各种顺序只是为了清楚描述某一个实施例,并不意味着是必须的顺序,除非另有说明其中某个顺序是必须遵循的。In addition, the features, operations, or features described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be sequentially exchanged or adjusted in a manner obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for clearly describing a certain embodiment, and are not meant to be a necessary sequence, unless a certain sequence is required to be followed unless otherwise stated.
本文中为部件所编序号本身,例如“第一”、“第二”等,仅用于区分所描述的对象,不具有任何顺序或技术含义。而本发明所说“连接”、“联接”,如无特别说明,均包括直接和间接连接(联接)。The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the described objects and do not have any sequence or technical meaning. The terms "connection" and "connection" in the present invention include direct and indirect connection (connection) unless otherwise specified.
下面对本发明一些实施例的样本分析装置的结构进行说明。The structure of the sample analysis device according to some embodiments of the present invention will be described below.
样本分析装置是是用于分析和测定样本的仪器。不妨以凝血分析仪为例,对样本分析装置的测试流程进行一个举例说明。凝血分析仪的测试流程一般如下:向反应杯中完成样本的加样、试剂的加样,以制备成反应液,再对反应液进行混匀和孵育后,将反应杯放置于测定部件中,测定部件能够向反应杯中的反应液照射多波长光,并通过凝固法、免疫比浊法或发色底物法等解析,来得到反应液随着时间变化的凝固反应曲线,从而进一步计算出反应液的凝固时间或其他凝血相关性能参数。由于凝血分析仪中为得到检测得到反应液随着时间变化的凝固反应曲线,因此,为了获得正确的测定结果,测试流程中,样本和试剂的添加时间、孵育时间等时间边界条件需要严格被设定和控制。The sample analysis device is an instrument used to analyze and measure samples. Take the coagulation analyzer as an example to illustrate the test process of the sample analysis device. The test procedure of a blood coagulation analyzer is generally as follows: complete sample addition and reagent addition into the reaction cup to prepare a reaction solution, and after mixing and incubating the reaction solution, the reaction cup is placed in the measurement part. The measuring part can irradiate the reaction liquid in the cuvette with multi-wavelength light, and analyze it by coagulation method, immunoturbidimetric method, or chromogenic substrate method to obtain the coagulation reaction curve of the reaction liquid over time, so as to further calculate The clotting time of the reaction solution or other clotting-related performance parameters. Since the coagulation analyzer is used to obtain the coagulation reaction curve of the reaction solution over time, in order to obtain the correct measurement result, the time boundary conditions such as the addition time of the sample and the reagent and the incubation time must be strictly set in the test process. Set and control.
请参照图1,为本发明一些实施例的样本分析装置的结构示意图。本发明一些实施例的样本分析装置可以包括机壳1、反应杯装载部件10、样本部件20、样本分注部件30、试剂承载部件40、一个或多个试剂分注部件60、一个或多个处理单元50和调度部件70。需要说明的是,图1中显示的是具有两个试剂分注部件60和两个处理单元50的例子,但本领域技术人员可以理解的是,这仅是用于示例,并不用于限定试剂分注部件60和处理单元50的数量只能是两个。下面对样本 分析装置中的各部件进行具体的说明。Please refer to FIG. 1, which is a schematic structural diagram of a sample analysis device according to some embodiments of the present invention. The sample analysis device of some embodiments of the present invention may include a casing 1, a cuvette loading part 10, a sample part 20, a sample dispensing part 30, a reagent carrying part 40, one or more reagent dispensing parts 60, one or more The processing unit 50 and the scheduling component 70. It should be noted that the example shown in FIG. 1 is an example with two reagent dispensing parts 60 and two processing units 50, but those skilled in the art will understand that this is only for example, and is not used to limit the reagents. The number of the dispensing part 60 and the processing unit 50 can only be two. The following is a detailed description of each component in the sample analysis device.
机壳1为样本分析装置的仪器壳体,例如其可以具有基本呈长方体或正方体的箱子形状,其功能可以是收纳样本分析装置中的一些部件。例如一些实施例中,机壳1包括沿第一方向的第一侧边1a和沿第二方向的第二侧边1b。The casing 1 is the instrument housing of the sample analysis device. For example, it may have a box shape that is basically a cuboid or a cube, and its function may be to accommodate some parts of the sample analysis device. For example, in some embodiments, the casing 1 includes a first side 1a along the first direction and a second side 1b along the second direction.
本文所涉及的第一方向和第二方向,在一些实施例中,这两个方向即第一方向和第二方向可以垂直,例如第一方向为图中的Y方向,第二方向为图中的X方向。The first direction and the second direction referred to herein, in some embodiments, the two directions, that is, the first direction and the second direction, may be perpendicular, for example, the first direction is the Y direction in the figure, and the second direction is the The X direction.
反应杯装载部件10用于供应并运载空反应杯。样本分析装置在工作过程中,需要不断地使用到空反应杯来完成一个个的测试项目,样本分析装置通过向空反应杯中加入样本和试剂以制备、孵育和测定反应液,从而得到项目的测试结果。反应杯装载部件10可以将空的反应杯加载到预定位置,样本分注机构从样本部件20中吸取样本后排入到上述预定位置上的空的反应杯。The cuvette loading part 10 is used for supplying and carrying empty cuvettes. In the working process of the sample analysis device, it is necessary to continuously use the empty reaction cup to complete each test item. The sample analysis device adds samples and reagents to the empty reaction cup to prepare, incubate and measure the reaction solution to obtain the project’s results. Test Results. The cuvette loading part 10 can load an empty cuvette to a predetermined position, and the sample dispensing mechanism sucks a sample from the sample part 20 and discharges it into the empty cuvette at the predetermined position.
样本部件20用于供应承载有待测试样本的样本架。一些实施例中,样本部件20可以设置于机壳1内。样本部件20有多种实现的方式。The sample part 20 is used to supply a sample rack carrying a sample to be tested. In some embodiments, the sample component 20 may be arranged in the casing 1. The sample part 20 can be implemented in multiple ways.
样本部件20的一种实现方式中,样本部件20可以为进样部件21,进样部件21用于将承载有样本的样本架调度到吸样位。图2就是一个例子,进样部件21可以包括装载区21a、进样通道21b和卸载区21c,其中进样通道21b上可以设置有吸样位21d。图中X方向和Y方向是垂直的,X1方向和X2方向是相反的方向,Y1方向和Y2方向也是相反的方向。用户可以将承载有待测试样本的样本架放置到装载区21a,装载区21a将样本架向图中Y1方向移动以进入进样通道21b,样本架可以在进样通道21b沿X1方向移动并经过吸样位,样本架上的样本在经过吸样位时能够被样本分注部件30吸取样本,样本架之后再沿Y2方向由进样通道21b进入到卸载区21c,用户可以从卸载区21c中取出样本架。进样部件21比较适合大批量的样本测试场合,并且进样部件21可以与样本分析装置独立地设置,当样本分析装置需要接入到流水线形式的测试系统中时,可以直接将进样部件21拆除。In an implementation manner of the sample component 20, the sample component 20 may be a sample injection component 21, and the sample injection component 21 is used to schedule the sample rack carrying the sample to the sample suction position. Fig. 2 is an example. The sampling component 21 may include a loading area 21a, a sampling channel 21b, and an unloading area 21c, wherein the sampling channel 21b may be provided with a sample suction position 21d. In the figure, the X direction and the Y direction are perpendicular, the X1 direction and the X2 direction are opposite directions, and the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a. The loading area 21a moves the sample rack to the Y1 direction in the figure to enter the sampling channel 21b. The sample rack can move along the X1 direction in the sampling channel 21b and pass through the suction. Sample position, the sample on the sample rack can be sucked by the sample dispensing part 30 when passing the sample aspiration position. After the sample rack enters the unloading area 21c from the sampling channel 21b along the Y2 direction, the user can take it out of the unloading area 21c Sample rack. The sample injection component 21 is more suitable for large-scale sample testing occasions, and the sample injection component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to the test system in the form of an assembly line, the sample injection component 21 can be directly connected. tear down.
样本部件20的另一种实现方式中,样本部件20可以为样本放置区22,样本放置区22用于放置承载有待测样本的样本架。图3就是一个例子。样本放置区22可以具有多个通道22a,每个通道22a可以放置一个样本架,用户可以沿图中Y1方向 将样本架推入通道22a;样本分注部件30可以依次吸取各通道22a内样本架上的样本;在样本架上的样本都被吸取后,用户可以沿图中Y2方向将样本架拉出通道22a。样本放置区22不需要对样本架进行调度,因此占用体积较小,有利于缩小样本分析装置的尺寸,对于样本分析装置的小型化设计十分有利。In another implementation of the sample component 20, the sample component 20 may be a sample placement area 22, and the sample placement area 22 is used to place a sample rack carrying a sample to be tested. Figure 3 is an example. The sample placement area 22 can have multiple channels 22a, and each channel 22a can place a sample rack. The user can push the sample rack into the channel 22a along the Y1 direction in the figure; the sample dispensing component 30 can suck the sample racks in each channel 22a in turn After the samples on the sample rack are all sucked, the user can pull the sample rack out of the channel 22a along the Y2 direction in the figure. The sample placement area 22 does not require scheduling of the sample rack, so it occupies a small volume, which is beneficial to reduce the size of the sample analysis device, and is very beneficial to the miniaturized design of the sample analysis device.
样本分注部件30用于从吸样位吸取样本并排放到位于加样位的反应杯中。一些实施例中,样本分注部件30可以设置于机壳1内。一些实施例中,样本分注机构30可以包括样本针,样本针被二维或三维驱动机构驱动进行二维或三维方向上的运动。一些实施例中,样本针可以为一根或多根。为了简化运动轨迹,缩小样本分析装置的体积和尺寸,可以将吸样位与反应杯装载部件10加载空反应杯到的预定位置设计成在一条直线上,例如沿第一方向的一条直线上,这样样本针只需要在第一方向在吸样位与上述预定位置之间往复运动,既提高了样本针的运动速度,也有利于缩小样本分析装置的尺寸,对于样本分析装置的小型化设计十分有利。The sample dispensing component 30 is used for aspirating samples from the sample suction position and discharging them into the reaction cup located at the sample adding position. In some embodiments, the sample dispensing component 30 may be arranged in the casing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, there may be one or more sample needles. In order to simplify the movement trajectory and reduce the volume and size of the sample analysis device, the sample suction position and the predetermined position where the cuvette loading part 10 loads the empty cuvette can be designed to be on a straight line, such as a straight line along the first direction. In this way, the sample needle only needs to reciprocate between the sample suction position and the above-mentioned predetermined position in the first direction, which not only improves the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very important for the miniaturization design of the sample analysis device. favorable.
试剂承载部件40用于承载试剂,例如试剂承载部件40可以具有多个用于承载试剂容器的位置,试剂容器则用于承载试剂。一般地,试剂承载部件40可以为所承载的试剂提供制冷等功能,从而确保试剂的活性。一些实施例中,试剂承载部件40可以设置于机壳1内。一些实施例中,试剂承载部件40呈圆盘状结构设置,其具有多个用于承载试剂容器的位置,试剂承载部件40能够转动并带动其承载的试剂容器转运,从而将试剂容器转动到吸试剂位,以供试剂分注部件60吸取试剂——例如试剂承载部件40包括用于驱动其旋转的第一驱动组件,该第一驱动组件驱动试剂承载部件40转动,用于将试剂容器转动到吸试剂位。下面对呈圆盘状结构设置的试剂承载部件40进行具体说明。The reagent carrying component 40 is used to carry reagents. For example, the reagent carrying component 40 may have multiple positions for carrying reagent containers, and the reagent containers are used to carry reagents. Generally, the reagent carrying member 40 can provide functions such as refrigeration for the carried reagent, so as to ensure the activity of the reagent. In some embodiments, the reagent carrying member 40 may be disposed in the casing 1. In some embodiments, the reagent carrying member 40 is arranged in a disk-shaped structure, which has a plurality of positions for carrying reagent containers, and the reagent carrying member 40 can rotate and drive the reagent container carried by it to transfer, thereby rotating the reagent container to suction. The reagent position is used for the reagent dispensing part 60 to suck reagents—for example, the reagent carrying part 40 includes a first driving assembly for driving the reagent carrying part 40 to rotate, and the first driving assembly drives the reagent carrying part 40 to rotate to rotate the reagent container to Suction reagent position. The reagent carrying member 40 arranged in a disk-shaped structure will be described in detail below.
请参照图4(a),一些具体的实施例中,试剂承载部件40呈圆盘状结构设置,其具有多个用于放置试剂联杯41的位置,试剂联杯41均包括一个或多个用于盛放项目测试所需要试剂的腔体,一种试剂放置在一个腔体中;试剂承载部件40包括用于驱动其旋转的第一驱动组件,该第一驱动组件驱动试剂承载部件40转动,用于将装有项目所需试剂的试剂联杯41的腔体转动到相应的吸试剂位。一个例子中,试剂联杯41均至少包括用于承载第一试剂的第一腔体41a和用于承载 第二试剂的第二腔体41b,例如试剂联杯41至少包括用于承载混合试剂R1的第一腔体41a和用于承载触发试剂R2的第二腔体41b;试剂承载部件40包括第一吸试剂位和不同于第一吸试剂位的第二吸试剂位,第一驱动组件驱动试剂承载部件40转动并带动试剂联杯41转动,以将试剂联杯41的第一腔体41a转动到第一吸试剂位;第一驱动组件驱动试剂承载部件40转动并带动试剂联杯41转动,以将第二腔体41b转动到第二吸试剂位。4 (a), in some specific embodiments, the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for placing the reagent coupling cup 41, each of the reagent coupling cups 41 includes one or more A cavity for containing reagents required for project testing, a kind of reagent is placed in a cavity; the reagent carrying member 40 includes a first driving component for driving it to rotate, and the first driving component drives the reagent carrying component 40 to rotate , Used to rotate the cavity of the reagent union cup 41 containing the reagents required by the project to the corresponding reagent suction position. In an example, the reagent coupling cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent. For example, the reagent coupling cup 41 includes at least a mixed reagent R1. The first cavity 41a and the second cavity 41b for carrying the trigger reagent R2; the reagent carrying member 40 includes a first reagent suction position and a second reagent suction position different from the first reagent suction position, and the first drive assembly drives The reagent carrying component 40 rotates and drives the reagent coupling cup 41 to rotate to rotate the first cavity 41a of the reagent coupling cup 41 to the first reagent suction position; the first driving assembly drives the reagent carrying component 40 to rotate and drives the reagent coupling cup 41 to rotate , To rotate the second cavity 41b to the second reagent suction position.
请参照图4(b),一些具体的实施例中,试剂承载部件40呈圆盘状结构设置,其具有多个用于承载第一试剂的第一试剂容器42的位置,并具有多个用于承载第二试剂的第二试剂容器43的位置。试剂承载部件40包括用于驱动其旋转的第一驱动组件,第一驱动组件驱动试剂承载部件40转动并带动第一试剂容器42转动,以将第一试剂容器42转动到第一吸试剂位;第一驱动组件驱动试剂承载部件40转动并带动第二试剂容器43转动,以将第二试剂容器43转动到第二吸试剂位。一个例子中,试剂承载部件40可以包括多圈能够独立转动的轨道。例如试剂承载部件40可以包括两圈轨道——内圈和外圈轨道,外圈轨道上可以设置多个第一试剂容器42的位置,相应地,内圈轨道上则可以设置多个第二试剂容器43的位置,通过第一驱动组件驱动内圈和外圈轨道独立地转动。Please refer to Figure 4 (b), in some specific embodiments, the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for the first reagent container 42 for carrying the first reagent, and has a plurality of At the position of the second reagent container 43 that carries the second reagent. The reagent carrying component 40 includes a first driving component for driving the rotation of the reagent carrying component 40, and the first driving component drives the reagent carrying component 40 to rotate and drives the first reagent container 42 to rotate, so as to rotate the first reagent container 42 to the first reagent suction position; The first driving component drives the reagent carrying member 40 to rotate and drives the second reagent container 43 to rotate, so as to rotate the second reagent container 43 to the second reagent suction position. In an example, the reagent carrying member 40 may include multiple tracks that can rotate independently. For example, the reagent carrying member 40 may include two tracks-an inner ring and an outer track. A plurality of positions for the first reagent container 42 can be arranged on the outer ring track, and correspondingly, a plurality of second reagents can be arranged on the inner ring track. The position of the container 43 drives the inner ring and the outer ring track to rotate independently through the first drive assembly.
以上说明了两种试剂承载部件40,例如图4(a)是放置试剂联杯41的例子,图4(b)是通过多圈能够独立转动的轨道来实现试剂承载部件40的例子,本领域技术人员可以理解地,也可以结合这两种方式,通过多圈能够独立转动的轨道来实现试剂承载部件40,并且至少有一圈轨道或者每圈轨道上都具有多个用于放置试剂联杯41的位置,例如图5就是这样的一个例子,试剂承载部件40可以包括两圈轨道——内圈和外圈轨道,外圈轨道上可以设置多个放置试剂联杯41的位置,相应地,内圈轨道上也可以设置多个放置试剂联杯41的位置,通过第一驱动组件驱动内圈和外圈轨道独立地转动。Two types of reagent carrying members 40 have been described above. For example, FIG. 4(a) is an example of placing the reagent coupling cup 41, and FIG. 4(b) is an example of realizing the reagent carrying member 40 through a track that can rotate independently. The skilled person can understand that these two ways can also be combined to realize the reagent carrying member 40 through multiple tracks that can rotate independently, and at least one track or each track has multiple coupling cups 41 for placing reagents. For example, Figure 5 is an example of this. The reagent carrying member 40 can include two tracks—inner and outer tracks. The outer track can be provided with multiple positions for the reagent coupling cup 41. Correspondingly, the inner The ring track may also be provided with multiple positions for placing the reagent coupling cup 41, and the inner ring and the outer ring track are driven to rotate independently by the first drive assembly.
以上就是试剂承载部件40的一些说明。试剂承载部件40在工作周期内可以通过转动的方式,将测试项目所需要的相应试剂转动并调度到试剂分注部件60对应的吸试剂位,例如将第一试剂调度到第一吸试剂位,将第二试剂调度到第二吸试剂位。The above are some descriptions of the reagent carrying member 40. The reagent carrying part 40 can rotate and dispatch the corresponding reagent required by the test item to the reagent suction position corresponding to the reagent dispensing part 60 by rotating during the working cycle, for example, dispatch the first reagent to the first reagent suction position, The second reagent is dispatched to the second reagent suction position.
处理单元50用于接收承载有试样的反应杯,并对反应杯的试样进行处理。这里的试样指的是由样本和试剂构成的反应液。处理单元50可以有一个或多个。The processing unit 50 is used to receive a reaction cup carrying a sample, and process the sample in the reaction cup. The sample here refers to a reaction solution composed of a sample and a reagent. There may be one or more processing units 50.
请参照图6,一些实施例中,处理单元50至少有一个是用于孵育试样的反应部件51,反应部件51用于承载反应杯并对反应杯中的试样进行孵育。一些实施例中,反应部件51呈矩形状,具有多个反应杯放置位。一般地,反应部件51可以对各反应杯放置位上的反应杯中的反应液或者说试样进行加热,以对试样进行孵育,例如将反应杯中的试样加热并保持在37±0.5℃,具体的加热时间和加热到的温度可以由不同测试项目对应的加热参数来确定。一些实施例中,反应部件51的长度方向沿第一方向设置,例如沿图中的Y方向设置。Referring to FIG. 6, in some embodiments, at least one of the processing unit 50 is a reaction component 51 for incubating a sample, and the reaction component 51 is used to carry a reaction cup and incubate the sample in the reaction cup. In some embodiments, the reaction component 51 has a rectangular shape and has a plurality of reaction cup placement positions. Generally, the reaction component 51 can heat the reaction solution or sample in the reaction cups on each reaction cup placement position to incubate the sample, for example, heat the sample in the reaction cup and keep it at 37±0.5 ℃, the specific heating time and heating temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction member 51 is arranged along the first direction, for example, along the Y direction in the figure.
一些实施例中,处理单元50至少有一个是用于测定试样的测定部件52,测定部件52用于承载反应杯并对反应杯中的试样进行检测;一些实施例中,测定部件52呈矩形状,具有多个反应杯放置位。一般地,测定部件52可以为各反应杯放置位都配置一个检测部(图中未画出),每个检测部用于对对应反应杯放置位上的反应杯中的试样进行检测。一些实施例中,测定部件52的长度方向沿不同于第一方向的第二方向设置,例如沿图中的X方向设置。In some embodiments, at least one of the processing unit 50 is a measuring part 52 for measuring a sample. The measuring part 52 is used to carry a cuvette and detect the sample in the cuvette; in some embodiments, the measuring part 52 is Rectangular shape, with multiple reaction cup placement positions. Generally, the measuring component 52 can be equipped with a detection part (not shown in the figure) for each reaction cup placement position, and each detection part is used to detect the sample in the reaction cup at the corresponding cuvette placement position. In some embodiments, the length direction of the measuring component 52 is arranged along a second direction different from the first direction, for example, along the X direction in the figure.
一些实施例中,反应部件51和测定部件52以相邻的方式围绕试剂承载部件40设置。具体的一些实施例中,反应部件51和测定部件52分别沿第一侧边1a和第二侧边1b设置,并以相邻的方式围绕所述试剂承载部件40。In some embodiments, the reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40 in an adjacent manner. In some specific embodiments, the reaction component 51 and the measurement component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying member 40 in an adjacent manner.
矩形状的反应部件51和测定部件52分别沿第一侧边1a和第二侧边1b设置,并以相邻的方式围绕所述试剂承载部件40,可以节省空间,缩小样本分析装置的尺寸,同时也利于试剂承载部件40通过试剂分注部件60来与反应部件51和测定部件52进行交互。The rectangular reaction part 51 and the measuring part 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying part 40 in an adjacent manner, which can save space and reduce the size of the sample analysis device. At the same time, it is also advantageous for the reagent carrying part 40 to interact with the reaction part 51 and the measuring part 52 through the reagent dispensing part 60.
一些实施例中,样本部件20例如进样部件21、反应杯装载部件10、反应部件51和测定部件52围绕试剂承载部件40设置。本申请以试剂承载部件40来中心,围绕试剂承载部件40来设计反应杯的整个检测流程的调度轨迹,设计新颖,节省空间。In some embodiments, the sample component 20 such as the sample injection component 21, the cuvette loading component 10, the reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40. This application is centered on the reagent carrying component 40, and the scheduling trajectory of the entire detection process of the reaction cup is designed around the reagent carrying component 40, which is novel in design and saves space.
各处理单元50都可以配置有相应的加试剂中转位,例如反应部件51配置有至少一个用于放置反应杯的位置的孵育中转位51a,孵育中转位51a的数量可以为一个 或多个;当孵育中转位51a放置反应杯的位置设置为1个时,孵育中转位51a可以设置为位置可调整的方式,以使得放置在孵育中转位51a上的反应杯能够与第一试剂分注部件(第一试剂分注部件与反应部件对应,为反应部件中的反应杯添加试剂)中的各个试剂针进行位置对应,以接收各个试剂针分注的试剂。一些实施例中,孵育中转位51a设置于所述试剂承载部件40和反应部件51之间。测定部件52配置有至少一个用于放置反应杯的位置的测定中转位52a,测定中转位52a的数量可以为一个或多个;一些实施例中,测定中转位52a设置于试剂承载部件40和测定部件52之间。当测定中转位52a放置反应杯的位置设置为1个时,测定中转位52a可以设置为位置可调整的方式,以使得放置在测定中转位52a上的反应杯能够与第二试剂分注部件(第二试剂分注部件与测定部件对应,为测定部件中的反应杯添加试剂)中的各个试剂针进行位置对应,以接收各个试剂针分注的试剂。Each processing unit 50 may be configured with a corresponding transposition during reagent addition. For example, the reaction component 51 is configured with at least one transposition 51a during incubation for placing a reaction cup, and the number of transposition 51a during incubation can be one or more; When the position of the incubation transposition 51a to place the reaction cup is set to 1, the incubation transposition 51a can be set in a position adjustable manner, so that the reaction cup placed on the incubation transposition 51a can be combined with the first reagent dispensing part (No. A reagent dispensing part is corresponding to the reaction part, and each reagent needle in the reaction cup in the reaction part is corresponding to the position to receive the reagent dispensed by each reagent needle. In some embodiments, the indexing position 51 a is arranged between the reagent carrying part 40 and the reaction part 51 during the incubation. The measurement part 52 is configured with at least one mid-measurement index 52a for placing the reaction cup, and the number of mid-measurement index 52a can be one or more; in some embodiments, the mid-measurement index 52a is provided on the reagent carrying member 40 and Between parts 52. When the position of the measuring index 52a for placing the reaction cup is set to 1, the measuring index 52a can be set in a position adjustable manner, so that the reaction cup placed on the measuring index 52a can be combined with the second reagent dispensing part ( The second reagent dispensing part corresponds to the measuring part, and the reagent needles in the reaction cup in the measuring part are matched in position to receive the reagent dispensed by the reagent needles.
图6中所显示的是孵育中转位51a的数量为一个,每个孵育中转位51a具有两个反应杯的放置位,例如用于放置反应杯的第一位置和第二位置;测定中转位52a的数量为一个,每个测定中转位52a具有两个反应杯的放置位,例如用于放置反应杯的第三位置和第四位置。Figure 6 shows that the number of transposition 51a in the incubation is one, and each transposition 51a in the incubation has two placement positions for the reaction cup, for example, the first position and the second position for placing the reaction cup; the transposition 52a is measured during the incubation. The number is one, and each index 52a has two placement positions for the reaction cup in each measurement, for example, the third position and the fourth position for placing the reaction cup.
试剂分注部件60用于从吸试剂位吸取试剂并排放到加试剂位的反应杯中。例如试剂分注部件60能够从本文所提及的第一吸试剂位吸取第一试剂并排放到反应杯中;试剂分注部件60能够从本文所提及的第二试剂位吸取第二试剂并排放到反应杯中。一些实施例中,试剂分注部件60可以设置于机壳1内。The reagent dispensing component 60 is used for sucking reagents from the reagent suction position and discharging them into the reaction cup of the reagent adding position. For example, the reagent dispensing part 60 can suck the first reagent from the first reagent suction position mentioned herein and discharge it into the reaction cup; the reagent dispensing part 60 can suck the second reagent from the second reagent position mentioned herein side by side. Put it in the reaction cup. In some embodiments, the reagent dispensing component 60 may be disposed in the casing 1.
试剂分注部件60可以由试剂针来实现。因此一些实施例中,试剂分注部件60包括试剂针,试剂针用于从试剂承载部件40吸取试剂并排放到反应杯中。The reagent dispensing unit 60 can be realized by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, and the reagent needle is used to suck the reagent from the reagent carrying component 40 and discharge it into the reaction cup.
从试剂针的数量这一角度来说,一些实施例中,试剂分注部件60可以具有多根试剂针,各试剂针以能够互相独立运动的方式所设置。具体可以这样来配置试剂针:每一个处理单元50都被配置有一组试剂针;试剂针用于从试剂承载部件40吸取试剂并排放到相应的处理单元50的反应杯中,且每组试剂针至少包括两根试剂针。例如,可以为反应部件51配置一组试剂针,为测定部件52配置一组试剂针。具体的一些实施例中,可以为反应部件51配置第一组试剂针,第一组试 剂针被以在吸试剂位和孵育中转位51a之间沿直线运动的方式所设置,第一组试剂针用于从吸试剂位吸取试剂并排放到位于孵育中转位51a的反应杯中,第一组试剂针至少包括一根试剂针;类似地,可以为测定部件52配置第二组试剂针,第二组试剂针被以在吸试剂位和测定中转位52a之间沿直线运动的方式所设置,第二组试剂针用于从吸试剂位吸取试剂并排放到位于测定中转位52a的反应杯中,第二组试剂针至少包括一根试剂针。From the perspective of the number of reagent needles, in some embodiments, the reagent dispensing part 60 may have multiple reagent needles, and the reagent needles are arranged in a manner that can move independently of each other. Specifically, the reagent needles can be configured as follows: each processing unit 50 is equipped with a group of reagent needles; the reagent needles are used to suck reagents from the reagent carrying member 40 and discharge them into the reaction cups of the corresponding processing units 50, and each group of reagent needles At least two reagent needles are included. For example, a set of reagent needles may be configured for the reaction part 51, and a set of reagent needles may be configured for the measurement part 52. In some specific embodiments, the reaction part 51 may be configured with a first set of reagent needles. The first set of reagent needles are arranged in a linear motion between the reagent suction position and the incubation position 51a. The first group of reagent needles For sucking reagents from the reagent suction position and discharging them into the reaction cup located at the incubation position 51a, the first set of reagent needles includes at least one reagent needle; similarly, a second set of reagent needles can be configured for the measurement component 52, and the second set of reagent needles The reagent needles of the group are arranged in a linear motion between the reagent suction position and the indexing position 52a in the measurement. The second group of reagent needles are used to suck reagents from the reagent suction position and discharge them into the reaction cup at the indexing position 52a in the measurement. The second group of reagent needles includes at least one reagent needle.
从试剂分注部件60的数量这一角度来说,一些实施例中,试剂分注部件60的数量与处理单元50的数量相等,且一个试剂分注部件60对应着一个处理单元50。上文中图1至图3都是这样的例子。具体地,可以是试剂分注部件60有两个,反应部件51对应着其中一个试剂分注部件60,测定部件52对应着另一个试剂分注部件60。为每个处理单元50配置一个试剂分注部件60,将检测项目的加试剂流程的动作分解,即每个试剂分注部件60只需为相应的处理单元50的反应杯加相应试剂,这使得检测项目的相应试剂的加样被分工完成,有利于提高效率。From the perspective of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. Figures 1 to 3 above are examples of this. Specifically, there may be two reagent dispensing components 60, the reaction component 51 corresponds to one of the reagent dispensing components 60, and the measuring component 52 corresponds to the other reagent dispensing component 60. A reagent dispensing component 60 is configured for each processing unit 50 to decompose the action of the reagent adding process of the test item, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50, which makes The sample addition of the corresponding reagents of the test items is completed by division of labor, which is beneficial to improve efficiency.
下面对试剂分注部件60的具体结构进行说明。The specific structure of the reagent dispensing unit 60 will be described below.
请参照图7,每个试剂分注部件60均包括多根试剂针61和用于导向这多根试剂针61作直线运动的导向组件62,以及驱动这多根试剂针61沿导向组件62作直线运动的第二驱动组件63。导向组件62沿吸试剂位和对应试剂分注部件60的处理单元50的加试剂中转位所确定的方向设置,以使得试剂针61从吸试剂位吸取试剂,并排放到与该试剂分注部件60对应的处理单元50的加试剂中转位的反应杯中。例如图7中靠左边的试剂分注部件60,其导向组件62沿吸试剂位和反应部件51的孵育中转位51a所确定的方向设置,以使得该试剂分注部件60的试剂针61从吸试剂位吸取试剂,并排放到位于孵育中转位51a的反应杯中;图7中靠右边的试剂分注部件60,其导向组件62沿吸试剂位和测定部件52的测定中转位52a所确定的方向设置,以使得该试剂分注部件60的试剂针61从吸试剂位吸取试剂,并排放到位于测定中转位52a的反应杯中。一些实施例中,每个试剂分注部件60的第二驱动组件53的数量与试剂针61的数量相等,多个第二驱动组件53各自独立的驱动力输出端相应作用于多根试剂针61,以相互独立地驱动多根试剂针61沿导向组件52在吸试剂位和加试剂中转位之间作直线运动。例如图7中所示的例子为 各试剂分注部件60都包括两根试剂针61的例子,每根试剂针61都独立地被各自的第二驱动组件63所驱动。Referring to FIG. 7, each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 for linear movement, and drives the plurality of reagent needles 61 to move along the guide assembly 62 The second drive assembly 63 for linear motion. The guide assembly 62 is arranged along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60, so that the reagent needle 61 sucks the reagent from the reagent suction position and discharges it to the reagent dispensing part. 60 corresponds to the reaction cup of the transposition in the reagent adding process unit 50 of the processing unit 50. For example, the reagent dispensing part 60 on the left side in FIG. 7 has a guide assembly 62 arranged along the direction determined by the incubation position 51a of the reagent suction position and the reaction part 51, so that the reagent needle 61 of the reagent dispensing part 60 is removed from the suction position. The reagent position sucks reagents and discharges them into the reaction cup located at the incubation position 51a; the reagent dispensing part 60 on the right in FIG. 7 is determined by the guide assembly 62 along the reagent suction position and the measuring position 52a of the measuring part 52. The direction is set so that the reagent needle 61 of the reagent dispensing part 60 sucks the reagent from the reagent suction position and discharges it into the reaction cup located at the index 52a in the measurement. In some embodiments, the number of the second driving components 53 of each reagent dispensing part 60 is equal to the number of the reagent needles 61, and the respective independent driving force output ends of the plurality of second driving components 53 act on the plurality of reagent needles 61 accordingly. , So as to independently drive the multiple reagent needles 61 along the guide assembly 52 to move linearly between the reagent suction position and the reagent adding position. For example, the example shown in FIG. 7 is an example in which each reagent dispensing part 60 includes two reagent needles 61, and each reagent needle 61 is independently driven by a respective second driving assembly 63.
导向组件52实现的方式有多种,下面试举几种。There are many ways to implement the guiding component 52, and a few are listed below.
图8为试剂分注部件60的侧面的一个示意图。一些实施例中,每个试剂分注部件60的导向组件62均包括:一根横梁62a,及多个并行且沿该横梁62a的长度方向设置的导向件62b;横梁62a沿吸试剂位和对应试剂分注部件60的处理单元50的加试剂中转位所确定的方向设置;导向件的数量62b与试剂分注部件60的试剂针61数量相等,且多根试剂针61分别与多个导向件62b滑动连接,以使得试剂针61沿导向件62b在吸试剂位与加试剂中转位之间作直线运动。一些实施例中,每一试剂分注部件60的试剂针61均设有两根;每一试剂分注部件60的导向件62b均设有两根,且两根导向件62b均为直线导轨;这两根直线导轨分别沿横梁62a的长轴方向设在横梁62a的两侧——图8显示的即是横梁62a一侧的示意图,另一侧的结构露出了一根试剂针61;两上述试剂针61分别设在横梁62a的两侧的直线导轨上,并与直线导轨滑动连接;试剂针61沿其所在的直线导轨,在吸试剂位和加试剂中转位之间作直线运动。FIG. 8 is a schematic view of the side surface of the reagent dispensing member 60. As shown in FIG. In some embodiments, the guide assembly 62 of each reagent dispensing part 60 includes: a beam 62a, and a plurality of guides 62b arranged in parallel and along the length of the beam 62a; the beam 62a extends along the reagent suction position and corresponds to The processing unit 50 of the reagent dispensing part 60 is set in the direction determined by the transposition in the reagent addition; the number of guides 62b is equal to the number of reagent needles 61 of the reagent dispensing part 60, and the plurality of reagent needles 61 are respectively connected to the plurality of guides 62b is slidably connected, so that the reagent needle 61 moves linearly along the guide 62b between the reagent sucking position and the reagent adding position. In some embodiments, each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guides 62b, and the two guides 62b are linear guides; The two linear guides are respectively arranged on both sides of the beam 62a along the long axis of the beam 62a-Figure 8 shows a schematic diagram of one side of the beam 62a, and the structure on the other side exposes a reagent needle 61; The reagent needles 61 are respectively arranged on the linear guide rails on both sides of the beam 62a and slidably connected with the linear guide rails; the reagent needle 61 moves linearly between the reagent suction position and the reagent adding position along the linear guide rail on which it is located.
这是通过一根横梁的两侧分别设置一根试剂针来实现一个试剂分注部件的实施方式。另一些实施例方式中,还可以通过两根并行的横梁,每根横梁的只设置一根试剂针的方式来实现一个试剂分注部件,下面具体说明。This is an embodiment in which a reagent needle is provided on both sides of a beam to realize a reagent dispensing part. In other embodiments, it is also possible to realize a reagent dispensing component by two parallel beams, each beam is provided with only one reagent needle, which will be described in detail below.
请参照图9和图10,一些实施例中,每个试剂分注部件60的导向组件62均包括:多根并行设置的横梁62a,及多个分别设在多根上述横梁62a上并沿上述横梁62a的长度方向设置的导向件62b;多根上述横梁62a沿吸试剂位和对应试剂分注部件60的处理单元50的加试剂中转位所确定的方向设置;导向件62b的数量与试剂分注部件60的试剂针61数量相等,且多根试剂针61分别与多个导向件62b滑动连接,以使得试剂针61沿导向件62b在吸试剂位与加试剂中转位之间作直线运动。一些实施例中,每一试剂分注部件60的多个导向件62b均为直线导轨,多根直线导轨分别沿多个横梁62a的长轴方向设置;多根试剂针61分别设在多个横梁62a的直线导轨上,并与直线导轨滑动连接;试剂针61沿其所在的直线导轨,在吸试剂位和加试剂中转位之间进行直线运动。9 and 10, in some embodiments, the guide assembly 62 of each reagent dispensing part 60 includes: a plurality of parallel beams 62a, and a plurality of beams 62a are respectively arranged on the plurality of the above and along the above A guide 62b is provided in the length direction of the cross beam 62a; a plurality of the above cross beams 62a are provided along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60; the number of the guide 62b is related to the reagent distribution. The number of reagent needles 61 of the injection part 60 is equal, and the reagent needles 61 are respectively slidably connected to the guide members 62b, so that the reagent needles 61 move linearly along the guide member 62b between the reagent suction position and the reagent adding position. In some embodiments, the plurality of guides 62b of each reagent dispensing part 60 are linear guides, and the plurality of linear guides are respectively arranged along the longitudinal direction of the plurality of beams 62a; the plurality of reagent needles 61 are respectively arranged on the plurality of beams 62a. 62a is on the linear guide rail and is slidably connected to the linear guide rail; the reagent needle 61 moves linearly between the reagent suction position and the reagent loading position along the linear guide rail where it is located.
在一些实施例中,每个试剂分注部件60中导向组件52的横梁52a,均固定设于吸试剂位和对应试剂分注部件60的处理单元50的加试剂中转位的上方位置。In some embodiments, the beam 52a of the guide assembly 52 in each reagent dispensing component 60 is fixedly arranged at the reagent suction position and the upper position of the reagent adding position of the processing unit 50 corresponding to the reagent dispensing component 60.
通过横梁结构来实现多针直线运动的试剂分注部件60,试剂针61的运动轨迹不会占用太多空间和尽量减少了对其他部件的布局干扰,使得样本分析装置的结构可以更加紧凑,十分有利于样本分析装置的小型化设计。The cross-beam structure realizes the reagent dispensing part 60 with multiple needles moving linearly. The movement trajectory of the reagent needle 61 does not take up too much space and minimizes the layout interference with other parts, so that the structure of the sample analysis device can be more compact and very compact. It is conducive to the miniaturization design of the sample analysis device.
一些实施例中,不同试剂分注部件60的试剂针61,互相之间的沿直线运动的轨迹不交叉,这使得不同试剂分注部件60的试剂针61之间的运动不会受到互相的干扰,有利于提高测试速度。In some embodiments, the trajectories of the reagent needles 61 of different reagent dispensing parts 60 do not intersect each other, so that the movement of the reagent needles 61 of different reagent dispensing parts 60 will not be interfered with each other. , Is conducive to improving the test speed.
一些实施例中,至少有一个处理单元50,其加试剂中转位包括与该处理单元50对应的试剂分注部件60的试剂针61数量相同的反应杯放置位。例如图6中的例子,反应部件51所具有的加试剂中转位即为图中的孵育中转位51a,孵育中转位51a可以放置两个反应杯;反应部件51对应的试剂分注部件60的试剂针61数量则为两根。图6中,测定部件52所具有的加试剂中转位即为图中的测定中转位52a,测定中转位52a可以放置两个反应杯;测定部件52对应的试剂分注部件60的试剂针61数量则为两根。一些实施例中,吸试剂位的数量与试剂针的数量相同。例如图6中共有两个试剂分注部件60,每个试剂分注部件60具有两根试剂针61,因此吸试剂位的数量为四个。试剂针的数量与加试剂位的数量都相同,使得各试剂针可以明确分工,给各自的加试剂位上的反应杯加试剂,有利于提高测试速度。In some embodiments, there is at least one processing unit 50, and the transposition during reagent addition includes the same number of reaction cup placement positions of the reagent needle 61 of the reagent dispensing part 60 corresponding to the processing unit 50. For example, in the example in FIG. 6, the reagent-adding transposition of the reaction component 51 is the incubation transposition 51a in the figure, and the incubation transposition 51a can place two reaction cups; the reagent of the reagent dispensing component 60 corresponding to the reaction component 51 The number of needles 61 is two. In Fig. 6, the reagent-adding indexing position of the measuring part 52 is the measuring indexing position 52a in the figure. The measuring indexing position 52a can hold two reaction cups; the number of reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 There are two. In some embodiments, the number of reagent suction positions is the same as the number of reagent needles. For example, there are two reagent dispensing parts 60 in FIG. 6, and each reagent dispensing part 60 has two reagent needles 61, so the number of reagent suction positions is four. The number of reagent needles and the number of reagent adding positions are the same, so that each reagent needle can clearly divide the labor, and adding reagents to the reaction cups on the respective reagent adding positions is beneficial to increase the test speed.
一些实施例中,同一试剂分注部件60中的试剂针61用于吸取同一类型试剂。例如反应部件51所对应的试剂分注部件60的试剂针61都用于吸取第一试剂,测定部件52所对应的试剂分注部件60的试剂针61都用于吸取第二试剂。不同的试剂分注部件60用于吸取不同的试剂,这使得各试剂分注部件60分工明确,有利于提高测试速度。In some embodiments, the reagent needle 61 in the same reagent dispensing part 60 is used to suck the same type of reagent. For example, the reagent needles 61 of the reagent dispensing part 60 corresponding to the reaction part 51 are all used for aspirating the first reagent, and the reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 are all used for aspirating the second reagent. Different reagent dispensing parts 60 are used to suck different reagents, which makes the division of labor of each reagent dispensing part 60 clear, which is beneficial to increase the test speed.
一些实施例中,试剂分注部件60的各试剂针61都设置有加热部件(图中未画出),用于对试剂针所吸取的试剂进行加热。由于各试剂分注部件60都包括多根试剂针61,不妨以两根试剂针为例,各试剂针61再分别设置有加热部件,由于试剂针61为两根,因此在保持原速的情况下,各试剂针61都有充分的时间——例如增加了一倍的时间来对吸取的试剂进行加热,从而使得试剂到达相应处理 单元50时,试剂的温度已经比较接近预定的温度了,即试剂已经被充分预热了。In some embodiments, each reagent needle 61 of the reagent dispensing component 60 is provided with a heating component (not shown in the figure) for heating the reagent sucked by the reagent needle. Since each reagent dispensing part 60 includes multiple reagent needles 61, two reagent needles may be used as an example. Each reagent needle 61 is further provided with a heating part. Since there are two reagent needles 61, the original speed is maintained. Each reagent needle 61 has sufficient time—for example, doubled the time to heat the sucked reagent, so that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already relatively close to the predetermined temperature, that is, The reagents have been fully preheated.
以上就是试剂分注部件60的一些说明。下面不妨以处理单元50的数量为二,且具体为反应部件51和测定部件52为例,说明试剂分注部件60与处理单元50的配合关系和相应结构。The above are some descriptions of the reagent dispensing unit 60. Hereinafter, the number of the processing unit 50 may be two, and specifically the reaction component 51 and the measuring component 52 as an example, to illustrate the matching relationship and the corresponding structure of the reagent dispensing component 60 and the processing unit 50.
一些实施例中,反应部件51所对应的试剂分注部件60为第一试剂分注部件,测定部件52对应的试剂分注部件60为第二试剂分注部件,下面具体说明。In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measuring component 52 is a second reagent dispensing component, which will be described in detail below.
一些实施例中,第一试剂分注部件60包括第一横梁6a和第一组试剂针,第一组试剂针至少包括多根第一试剂针6b,例如两根;这多根第一试剂针61设在第一横梁62a上,并沿第一横梁62a的长轴方向作直线运动,以从第一吸试剂位吸取第一试剂并排放到位于孵育中转位51a的反应杯中。一些实施例中,第一横梁62a沿第一吸试剂位和孵育中转位51a所确定的方向设置,且第一横梁62a固定设于第一吸试剂位和孵育中转位51a对应的上方位置。In some embodiments, the first reagent dispensing part 60 includes a first beam 6a and a first set of reagent needles. The first set of reagent needles includes at least a plurality of first reagent needles 6b, such as two; 61 is arranged on the first beam 62a and moves linearly along the long axis of the first beam 62a to suck the first reagent from the first reagent suction position and discharge it into the reaction cup located at the incubation position 51a. In some embodiments, the first beam 62a is arranged along the direction determined by the first reagent suction position and the incubation index 51a, and the first beam 62a is fixed at the upper position corresponding to the first reagent suction position and the incubation index 51a.
一些实施例中,第一试剂分注部件60的第一横梁62a设置为一根,上述的多根第一试剂针61并行设在这一根第一横梁62a上,并沿第一横梁62a的长轴方向作直线运动。以第一组试剂针具有两根第一试剂针61为例,第一横梁62a沿其长轴方向的两侧分别设置有一根直线导轨,两第一试剂针61分别设在第一横梁62a的两侧的直线导轨上,第一试剂针61沿其所在的直线导轨在第一吸试剂位和孵育中转位51a之间作直线运动。这是通过一根第一横梁的两侧分别设置一根第一试剂针来实现第一试剂分注部件的实施方式。In some embodiments, the first crossbeam 62a of the first reagent dispensing part 60 is set as one, and the multiple first reagent needles 61 described above are arranged in parallel on this first crossbeam 62a, and are arranged along the first crossbeam 62a. Make a linear movement in the direction of the long axis. Taking the first group of reagent needles with two first reagent needles 61 as an example, a linear guide rail is respectively provided on both sides of the first cross beam 62a along the long axis direction, and the two first reagent needles 61 are respectively provided on the first cross beam 62a. On the linear guide rails on both sides, the first reagent needle 61 moves linearly along the linear guide rail where it is located between the first reagent suction position and the incubation index 51a. This is an embodiment in which a first reagent needle is provided on both sides of a first beam to realize the first reagent dispensing part.
一些实施例中,第一试剂分注部件60的第一横梁62a数量与第一组试剂针的多根第一试剂针61的数量相等,每一上述第一横梁62a上设有一根第一试剂针61,且两两上述第一横梁62a相互平行设置。一些具体的实施例中,多个第一横梁62a均沿其长轴方向设置有一根直线导轨,多根第一试剂针61分别设在多个第一横梁62a的直线导轨上,供第一试剂针61在第一吸试剂位和孵育中转位51a之间进行直线运动。这是通过多根例如两根并行的第一横梁,每根第一横梁的只设置一根第一试剂针的方式来实现第一试剂分注部件的实施方式。In some embodiments, the number of the first beams 62a of the first reagent dispensing part 60 is equal to the number of the first reagent needles 61 of the first group of reagent needles, and each of the first beams 62a is provided with a first reagent. Needles 61, and two of the above-mentioned first beams 62a are arranged parallel to each other. In some specific embodiments, each of the plurality of first beams 62a is provided with a linear guide along its long axis, and the plurality of first reagent needles 61 are respectively provided on the linear guides of the plurality of first beams 62a for the first reagent The needle 61 moves linearly between the first reagent suction position and the incubation position 51a. This is the implementation of the first reagent dispensing part by means of multiple, for example, two parallel first beams, and each first beam is provided with only one first reagent needle.
一些实施例中,第一试剂分注部件60还包括多个相互独立驱动多根第一试剂针 作直线运动的驱动机构,例如第二驱动组件,多个第二驱动组件数量与多根第一试剂针的数量相等,且多个第二驱动组件各自独立的驱动力输出端分别作用于多根第一试剂针,以驱动多根第一试剂针沿第一横梁的长轴方向在第一吸试剂位与孵育中转位51a之间作直线运动。In some embodiments, the first reagent dispensing component 60 further includes a plurality of driving mechanisms that independently drive a plurality of first reagent needles to move linearly, such as a second driving assembly, the number of the plurality of second driving assemblies is different from the number of the first reagent needles. The number of reagent needles is equal, and the independent driving force output ends of the plurality of second driving components act on the plurality of first reagent needles to drive the plurality of first reagent needles in the first suction along the long axis direction of the first beam. There is a linear movement between the reagent position and the transposition 51a during the incubation.
不妨以上文中孵育中转位51a包括用于放置反应杯的第一位置和第二位置为例,那么在第一试剂分注部件60具有两根第一试剂针61的例子中,其中一根第一试剂针61沿第一横梁62a在第一吸试剂位和第一位置之间作直线运动,另一根第一试剂针61沿第一横梁62a在第一吸试剂位和第二位置之间作直线运动。As an example, the indexing position 51a in the above incubation includes the first position and the second position for placing the reaction cup as an example. Then, in the example in which the first reagent dispensing part 60 has two first reagent needles 61, one of the first reagent needles 61 is The reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the first position, and the other first reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the second position .
一些实施例中,第一试剂分注部件60还包括用于驱动第一组试剂针中的第一试剂针61分别在竖直方向上运动的第一Z向驱动组件64,第一Z向驱动组件64的数量与第一组试剂针中的第一试剂针61的数量相同;第一Z向驱动组件64均包括:用于导向第一试剂针61在竖直方向上运动的第一Z向导向件64a,以及用于驱动第一试剂针沿所述第一Z向导向件运动的第一Z向驱动件64b;第一试剂针61通过第一Z向导向件64a和第一Z向驱动件64b与第一横梁62a形成滑动连接,使得第一试剂针61可以在第一Z向驱动件64b的驱动下相对第一横梁62a作竖直方向上进行移动。本领域技术人员可以理解地,试剂针在进行往复的直线运动的情况下,在到达各位置时需要在垂直方向上进行运动,以完成吸试剂和排试剂等操作。In some embodiments, the first reagent dispensing component 60 further includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction. The number of the components 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles; the first Z-direction drive components 64 all include: a first Z-direction for guiding the first reagent needle 61 to move in the vertical direction A guide member 64a, and a first Z-direction driving member 64b for driving the first reagent needle to move along the first Z-direction member; the first reagent needle 61 is driven by the first Z-direction member 64a and the first Z-direction The member 64b forms a sliding connection with the first beam 62a, so that the first reagent needle 61 can move in the vertical direction relative to the first beam 62a under the drive of the first Z-direction driving member 64b. Those skilled in the art can understand that when the reagent needle performs a reciprocating linear motion, it needs to move in a vertical direction when reaching each position to complete operations such as reagent suction and discharge.
一些实施例中,第一试剂针61还可以设置有加热部件(图中未画出),用于对其所吸取的试剂进行加热。In some embodiments, the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.
以上是关于第一试剂分注部件60的一些说明,下面对第二试剂分注部件60进行说明。The above is some explanations about the first reagent dispensing part 60, and the second reagent dispensing part 60 will be explained below.
第二试剂分注部件60包括第二横梁62a和第二组试剂针,第二组试剂针至少包括多根第二试剂针61,例如两根;这多根第二试剂针61设在第二横梁62a上,并沿第二横梁62a的长轴方向作直线运动,以从第二吸试剂位吸取第二试剂并排放到位于测定中转位52a的反应杯中。一些实施例中,第二横梁62a沿第二吸试剂位和测定中转位52a所确定的方向设置,且第二横梁62a固定设于第二吸试剂位和测定中转位52a对应的上方位置。The second reagent dispensing part 60 includes a second beam 62a and a second set of reagent needles. The second set of reagent needles includes at least a plurality of second reagent needles 61, such as two; the plurality of second reagent needles 61 are provided in the second group of reagent needles. On the beam 62a and move linearly along the long axis of the second beam 62a to suck the second reagent from the second reagent suction position and discharge it into the reaction cup located at the index 52a in the measurement. In some embodiments, the second beam 62a is arranged along the direction determined by the second reagent suction position and the measuring index 52a, and the second beam 62a is fixedly arranged at the upper position corresponding to the second reagent suction position and the measuring index 52a.
一些实施例中,第二试剂分注部件60的第二横梁62a设置为一根,上述的多根 第二试剂针61并行设在这一根第二横梁62a上,并沿第二横梁62a的长轴方向作直线运动。以第二组试剂针具有两根第一试剂针61为例,第二横梁62a沿其长轴方向的两侧分别设置有一根直线导轨,两第二试剂针61分别设在第二横梁62a的两侧的直线导轨上,第二试剂针61沿其所在的直线导轨在第二吸试剂位和测定中转位52a之间作直线运动。这是通过一根第二横梁的两侧分别设置一根第二试剂针来实现第二试剂分注部件的实施方式。In some embodiments, the second crossbeam 62a of the second reagent dispensing part 60 is provided as one, and the multiple second reagent needles 61 described above are provided in parallel on this second crossbeam 62a and run along the second crossbeam 62a. Make a linear movement in the direction of the long axis. Taking the second set of reagent needles with two first reagent needles 61 as an example, a linear guide rail is respectively provided on both sides of the second cross beam 62a along the long axis direction, and the two second reagent needles 61 are respectively provided on the second cross beam 62a. On the linear guide rails on both sides, the second reagent needle 61 moves linearly between the second reagent suction position and the measuring index 52a along the linear guide rail where it is located. This is an embodiment in which a second reagent needle is provided on both sides of a second beam to realize the second reagent dispensing part.
一些实施例中,第二试剂分注部件60的第二横梁62a数量与第二组试剂针的多根第二试剂针61的数量相等,每一上述第二横梁62a上设有一根第二试剂针61,且两两上述第二横梁62a相互平行设置。一些具体的实施例中,多个第二横梁62a均沿其长轴方向设置有一根直线导轨,多根第二试剂针61分别设在多个第二横梁62a的直线导轨上,供第二试剂针61在第二吸试剂位和测定中转位52a之间进行直线运动。这是通过多根例如两根并行的第二横梁,每根第二横梁的只设置一根第二试剂针的方式来实现第二试剂分注部件的实施方式。In some embodiments, the number of the second beams 62a of the second reagent dispensing part 60 is equal to the number of the second reagent needles 61 of the second group of reagent needles, and each of the second beams 62a is provided with a second reagent. Needles 61, and two of the above-mentioned second beams 62a are arranged parallel to each other. In some specific embodiments, each of the plurality of second beams 62a is provided with a linear guide along its long axis, and the plurality of second reagent needles 61 are respectively provided on the linear guides of the plurality of second beams 62a for the second reagent. The needle 61 moves linearly between the second reagent suction position and the measuring index 52a. This is the implementation of the second reagent dispensing part by means of multiple, for example, two parallel second beams, and each second beam is provided with only one second reagent needle.
一些实施例中,第二试剂分注部件60还包括多个不同于所述第二驱动组件且相互独立地驱动多根第二试剂针作直线运动的驱动机构,例如第三驱动组件,第三驱动组件数量与多根第二试剂针的数量相等,且多个所述第三驱动组件各自独立的驱动力输出端分别作用于多根所述第二试剂针,以驱动多根所述第二试剂针沿第二横梁的长轴方向在第二试剂位与所述测定中转位之间作直线运动。第二驱动组件和第三驱动组件的结构可以相同。In some embodiments, the second reagent dispensing component 60 further includes a plurality of driving mechanisms that are different from the second driving assembly and independently drive a plurality of second reagent needles to move linearly, such as a third driving assembly, and a third driving mechanism. The number of driving components is equal to the number of the second reagent needles, and the independent driving force output ends of the third driving components act on the second reagent needles to drive the second reagent needles. The reagent needle moves linearly along the long axis direction of the second beam between the second reagent position and the indexing position in the measurement. The structure of the second driving component and the third driving component may be the same.
不妨以上文中测定中转位52a包括用于放置反应杯的第三位置和第四位置为例,那么在第二试剂分注部件60具有两根第二试剂针61的例子中,其中一根第二试剂针61沿第二横梁62a在第二吸试剂位和第三位置之间作直线运动,另一根第二试剂针61沿第二横梁62a在第二吸试剂位和第四位置之间作直线运动。As an example, the indexing position 52a includes the third position and the fourth position for placing the reaction cup in the above-mentioned measurement. Then, in the example in which the second reagent dispensing part 60 has two second reagent needles 61, one of the second reagent needles 61 is The reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the third position, and the other second reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the fourth position .
一些实施例中,第二试剂分注部件60还包括用于驱动第二组试剂针中的第二试剂针61分别在竖直方向上运动的第二Z向驱动组件64,第二Z向驱动组件64的数量与第二组试剂针中的第二试剂针61的数量相同;第二Z向驱动组件64均包括:用于导向第二试剂针61在竖直方向上运动的第二Z向导向件64a,以及用于驱动第二试剂针61沿第二Z向导向件64a运动的第二Z向驱动件64b;第二试剂针61通 过第二Z向导向件64a和第二Z向驱动件64b与第二横梁62a形成滑动连接,使得第二试剂针61可以在第二Z向驱动件64b的驱动下相对第二横梁62a作竖直方向上进行移动。In some embodiments, the second reagent dispensing component 60 further includes a second Z-direction driving assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction, respectively, and the second Z-direction driving The number of the components 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles; the second Z-direction drive components 64 all include: a second Z-direction for guiding the second reagent needle 61 to move in the vertical direction The guide member 64a, and the second Z-direction driving member 64b for driving the second reagent needle 61 to move along the second Z-direction member 64a; the second reagent needle 61 is driven by the second Z-direction member 64a and the second Z-direction The member 64b forms a sliding connection with the second beam 62a, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z-direction driving member 64b.
一些实施例中,第二试剂针61还可以设置有加热部件(图中未画出),用于对其所吸取的试剂进行加热。In some embodiments, the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.
一些实施例中,第一试剂分注部件60所具有的多根第一试剂针61在第一吸试剂位和孵育中转位51a之间的直线运动的轨迹为第一运动轨迹;第二试剂分注部件60所具有的多根第二试剂针61在第二吸试剂位和测定中转位52a之间的直线运动的轨迹为第二运动轨迹;其中第一运动轨迹与所述第二运动轨迹不交叉。In some embodiments, the trajectory of the linear movement of the plurality of first reagent needles 61 of the first reagent dispensing component 60 between the first reagent suction position and the incubation position 51a is the first movement trajectory; The trajectory of the linear movement of the multiple second reagent needles 61 of the injection component 60 between the second reagent suction position and the indexing position 52a in the measurement is the second movement trajectory; wherein the first movement trajectory is different from the second movement trajectory cross.
第一试剂分注部件60和第二试剂分注部件60的结构可以相同,只不过他们设置的方向不同,第一试剂分注部件60是向反应部件51的方向设置,用于和反应部件51配合,第二试剂分注部件60是向测定部件52的方向设置,用于和测定部件52配合。The structure of the first reagent dispensing part 60 and the second reagent dispensing part 60 may be the same, except that they are arranged in different directions. The first reagent dispensing part 60 is arranged in the direction of the reaction part 51 to be used with the reaction part 51. In cooperation, the second reagent dispensing part 60 is provided in the direction of the measuring part 52 to cooperate with the measuring part 52.
以上就是试剂分注部件60的一些说明。试剂分注部件60通过横梁式结构,使得试剂针61在试剂承载部件40的吸试剂位和对应处理单元的加试剂位之间不断进行往复的直线运动,完成相应试剂的吸取和排出。The above are some descriptions of the reagent dispensing unit 60. The reagent dispensing part 60 adopts a beam structure, so that the reagent needle 61 continuously reciprocates between the reagent suction position of the reagent carrying part 40 and the reagent adding position of the corresponding processing unit to complete the suction and discharge of the corresponding reagent.
不同试剂分注部件60的运动独立且互不干涉,因此对仪器的空间小型化和测试速度的提升起到了明显作用。The movements of the different reagent dispensing parts 60 are independent and do not interfere with each other, and therefore play a significant role in the miniaturization of the instrument space and the improvement of the test speed.
调度部件70用于调度反应杯,例如调度部件70将位于加样位中完成加样的反应杯按照检测的流程调度至各处理单元50中,例如调度部件70将孵育中转位51a上加完试剂例如第一试剂的反应杯调度到反应部件51,以及将测定中转位52a上加完试剂例如第二试剂的反应杯调度到测定部件52。下面对调度部件70的具体结构进行说明。The scheduling component 70 is used to schedule the reaction cups. For example, the scheduling component 70 schedules the reaction cups located in the sample loading position to complete the sample addition to each processing unit 50 according to the detection process. For example, the scheduling component 70 transfers the reagents to the position 51a during the incubation. For example, the reaction cup of the first reagent is dispatched to the reaction unit 51, and the reaction cup to which the reagent such as the second reagent has been added to the index 52a during the measurement is dispatched to the measurement unit 52. The specific structure of the scheduling component 70 will be described below.
请参照图11,一些实施例中调度部件70包括第一转运部件71、第二转运部件73和第三转运部件75,为了配合这三个转运部件71、73和75,一些实施例中,样本分析装置还设有第一缓存中转位77和第二缓存中转位78。一些实施例中,第一缓存中转位77可以采用固定缓存位设计,仅具有一个反应杯放置位,即仅可以放置一个反应杯,这样有利于缩小样本分析装置的体积和尺寸;类似地,第 一缓存中转位78可以采用固定缓存位设计,仅具有一个反应杯放置位,即仅可以放置一个反应杯,这样有利于缩小样本分析装置的体积和尺寸。当然,一些实施例中,第一缓存中转位77和第二缓存中转位78在采用固定缓存位设计时,也可以设计成具有多个反应杯放置位,从而使得调度上有更多的反应杯放置位。甚至,一些实施例中,第一缓存中转位77可以设计成移动或旋转式的缓存位,例如第一缓存中转位77可以包括能够被驱动以移动或旋转的反应杯放置位,这样在第一转运部件71将反应杯转运到第一缓存中转位77的过程中,第一缓存中转位77也可以被控制而移动或旋转到一预定的位置来接收第一转运部件71转运过来的反应杯,另外,在第二转运部件73需要将第一缓存中转位77上的反应杯转运走时,第一缓存中转位77也可以被控制而移动或旋转到一预定的位置来使得第二转运部件73能够更快地抓取到第一缓存中转位77上的反应杯;类似地,第二缓存中转位78可以包括能够被驱动以移动或旋转的反应杯放置位,这样在第二转运部件73将反应杯转运到第二缓存中转位78的过程中,第二缓存中转位78也可以被控制而移动或旋转到一预定的位置来接收第二转运部件73转运过来的反应杯,另外,在第三转运部件73需要将第二缓存中转位78上的反应杯转运走时,第二缓存中转位78也可以被控制而移动或旋转到一预定的位置来使得第三转运部件75能够更快地抓取到第二缓存中转位78上的反应杯;通过这样的设计,可以使得反应杯的整个转运过程更加的快速和耗时更少,提高了样本分析装置的效率和测试速度。Referring to FIG. 11, in some embodiments, the scheduling component 70 includes a first transfer component 71, a second transfer component 73, and a third transfer component 75. In order to cooperate with these three transfer components 71, 73, and 75, in some embodiments, the sample The analysis device is also provided with a first buffer index 77 and a second buffer index 78. In some embodiments, the index 77 in the first buffer can be designed with a fixed buffer position, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device; similarly, the first The indexing position 78 in a buffer can be designed with a fixed buffer position, and has only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device. Of course, in some embodiments, when the first buffer index 77 and the second buffer index 78 adopt a fixed buffer design, they can also be designed to have multiple cuvette placement positions, so that there are more cuvettes in the scheduling. Place a bit. Furthermore, in some embodiments, the index 77 in the first buffer may be designed as a moving or rotating buffer position. For example, the index 77 in the first buffer may include a reaction cup placement position that can be driven to move or rotate. In the process that the transfer component 71 transfers the cuvette to the first buffer index 77, the first buffer index 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the first transfer part 71. In addition, when the second transfer part 73 needs to transfer away the cuvette on the first buffer index 77, the first buffer index 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer part 73 Faster grabbing the cuvette on the index 77 in the first buffer; similarly, the index 78 in the second buffer may include a cuvette placement position that can be driven to move or rotate, so that the reaction cup in the second transfer part 73 During the transfer of the cuvette to the index 78 in the second buffer, the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the second transfer member 73. In addition, in the third When the transfer part 73 needs to transfer the cuvette on the index 78 in the second buffer, the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position so that the third transfer part 75 can grab faster Transfer the reaction cup on 78 to the second buffer; through this design, the entire transfer process of the reaction cup can be made faster and less time-consuming, which improves the efficiency and test speed of the sample analysis device.
第一转运部件71、第二转运部件73和第三转运部件75的具体实现方式有多种,例如导轨式的转运部件,通过将反应杯放置于导轨上来对反应杯进行转运;再例如转盘式的转运部件,通过将反应杯放置于转盘式的结构上,通过转盘本身的转运来将转盘所承载的反应杯转运到相应的位置;例如通过二维或三维的驱动机构来驱动抓杯手的方式,来实现第一转运部件71、第二转运部件73和第三转运部件75,通过抓杯手抓取反应杯,然后通过二维或三维的驱动机构来驱动抓杯手移动,从而实现将反应杯转运到相应的位置,下面不妨以地以抓杯手来实现转运部件的方式进行说明。There are many specific implementations of the first transfer component 71, the second transfer component 73 and the third transfer component 75, such as a rail-type transfer component, which transfers the cuvette by placing the cuvette on the rail; another example is a turntable type. By placing the reaction cup on the turntable structure, the reaction cup carried by the turntable is transferred to the corresponding position by the transfer of the turntable itself; for example, the two-dimensional or three-dimensional drive mechanism is used to drive the gripper In this way, the first transfer part 71, the second transfer part 73 and the third transfer part 75 are realized. The reaction cup is grasped by the cup grasping hand, and then the two-dimensional or three-dimensional driving mechanism is used to drive the cup grasping hand to move. The cuvette is transferred to the corresponding position, and the following description may be given by using a cup gripper to realize the transfer part.
请参照图12(a),第一转运部件71、第二转运部件73和第三转运部件75都包 括抓杯手79以及驱动抓杯手79运动的驱动部件。一些实施例中,抓杯手79用于夹持反应杯,例如图13就是抓杯手79的一个结构示意图。抓杯手79的开合可以由一个驱动机构和弹簧来共同实现,抓杯手79的打开可以由其驱动机构来驱动打开,当驱动机构不进行驱动时,则抓杯手79通过其弹簧自动闭合并夹紧所夹持的物体例如反应杯,一些例子中,反应杯上可以设置适配抓杯手夹持的一圈凸起。12(a), the first transfer component 71, the second transfer component 73 and the third transfer component 75 all include a cup gripper 79 and a driving component for driving the cup gripper 79 to move. In some embodiments, the cup gripper 79 is used to hold the reaction cup. For example, FIG. 13 is a schematic structural diagram of the cup gripper 79. The opening and closing of the cup gripper 79 can be realized by a driving mechanism and a spring. The opening of the cup gripper 79 can be driven by its driving mechanism. When the driving mechanism is not driven, the cup gripper 79 is automatically opened by its spring. Close and clamp the clamped object, such as a reaction cup. In some cases, a circle of protrusions adapted to be held by the gripping hand can be provided on the reaction cup.
下面对各转运部件及其功能进行说明。The following describes the transport components and their functions.
第一转运部件71用于将加样完成的反应杯运送到第一缓存中转位77。一些实施例中,第一转运部件71沿第一方向例如图中Y方向直线运动,将加样完成的反应杯运送到第一缓存中转位77。由于第一转运部件71走直线运动进行反应杯运动,相对降低了反应杯运送过程中所占用的样本分析装置的体积,有利于样本分析装置的小型化设计。The first transport component 71 is used for transporting the reaction cup after the sample addition is completed to the transfer position 77 in the first buffer. In some embodiments, the first transfer component 71 moves linearly in a first direction, such as the Y direction in the figure, and transports the reaction cup after sample loading to the index 77 in the first buffer. Since the first transfer component 71 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturized design of the sample analysis device.
请参照图14,一些实施例中,样本分析装置还可以设置加样位10a、预稀释位10b、第一抛杯位10c和第二抛杯位10d。一些实施例中,第一转运部件71可以沿第一方向例如图中Y方向在加样位10a、预稀释位10b、第一抛杯位10c和第一缓存中转位77之间运动。加样位10a可以是上文提及的反应杯装载部件10将空的反应杯加载到的预定位置,一般地,样本分注部件30都是从吸样位吸取样本并排放到位于加样位10a的反应杯中,以完成加样。在一些情况下,样本需要进行预稀释,因此这种情况下,第一转运部件71先将加样位10a上的空反应杯转运到预稀释位10b,样本分注部件30从吸样位吸取样本并排放到位于预稀释位10b的反应杯中,之后对预稀释位10b的反应杯中的样本进行稀释;在这个过程中,反应杯装载部件10又将新的空反应杯加载到加样位10a上,然后样本分注部件30再从预稀释位10b上的反应杯中吸取已经过预稀释的样本并排放到加样位10a,从而完成加样;第一转运部件71再将预稀释位10b上的反应杯进行抛杯处理,例如转运到第一抛杯位10c进行抛杯。Please refer to FIG. 14, in some embodiments, the sample analysis device may also be provided with a sample adding position 10 a, a pre-dilution position 10 b, a first throwing cup position 10 c, and a second throwing cup position 10 d. In some embodiments, the first transfer component 71 can move between the sample loading position 10a, the pre-dilution position 10b, the first throwing cup position 10c, and the first buffer indexing position 77 along the first direction, such as the Y direction in the figure. The sample loading position 10a may be the predetermined position where the empty reaction cup is loaded by the reaction cup loading part 10 mentioned above. Generally, the sample dispensing part 30 sucks the sample from the sample suction position and discharges it to the sample loading position. 10a in the reaction cup to complete the sample addition. In some cases, the sample needs to be pre-diluted. Therefore, in this case, the first transfer component 71 first transfers the empty cuvette on the sample loading position 10a to the pre-dilution position 10b, and the sample dispensing component 30 sucks from the sample suction position The samples are discharged side by side into the reaction cup at the pre-dilution position 10b, and then the sample in the reaction cup at the pre-dilution position 10b is diluted; in this process, the reaction cup loading part 10 loads a new empty reaction cup into the sample Position 10a, and then the sample dispensing component 30 sucks the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it to the sample addition position 10a to complete the sample addition; the first transfer component 71 then pre-dilutes The reaction cup on position 10b is tossed, for example, it is transferred to the first toss position 10c for the tossing.
如上所述,一些实施例中,第一转运部件71只需要沿第一方向运动即可,因此第一转运部件71的驱动部件可以是一个二维的驱动部件,用于驱动第一转运部件71的抓杯手79沿第一方向和竖直方向移动,其中第一方向可以是图中的Y方向 ,竖直方向为垂直图中纸面的方向。请参照图12(b),一些实施例中,第一转运部件71包括第一方向导向件71a、第一方向驱动部件71b、竖直方向导向件71c和竖直方向驱动部件71d;竖直方向导向件71c上滑动设置有第一转运部件71的抓杯手79,并通过竖直方向导向件71c的驱动,使得抓杯手79可以沿竖直方向导向件71c在竖直方向移动;第一方向导向件71a上滑动设置有竖直方向导向件71c,并通过第一方向驱动部件71b的驱动,使得竖直方向导向件71c可以沿第一方向导向件71a在第一方向上移动,从而带动第一转运部件71的抓杯手79也沿第一方向上移动,通过这样的结构,就可以实现第一转运部件71的抓杯手79在第一方向和竖直方向这两维方向上移动。具体的一些实施例中,第一方向导向件71a可以包括第一导轨;第一方向驱动部件71b可以包括第一步进电机、第一从动轮和第一同步带,第一同步带套接于第一步进电机和第一从动轮之间,竖直方向导向件71c可以与第一同步带固定连接;类似地,竖直方向导向件71c可以包括竖直导轨;竖直方向驱动部件71d可以包括升降步进电机和竖直丝杆,竖直丝杆上可以螺纹套设有一个安装板,用于安装第一转运部件71的抓杯手79。一些实施例中,第一转运部件71还可以包括第一支架71f,用于安装上述的第一方向导向件71a。As mentioned above, in some embodiments, the first transfer component 71 only needs to move in the first direction, so the driving component of the first transfer component 71 may be a two-dimensional drive component for driving the first transfer component 71 The cup gripper 79 moves along a first direction and a vertical direction, where the first direction can be the Y direction in the figure, and the vertical direction is a direction perpendicular to the paper in the figure. 12(b), in some embodiments, the first transfer member 71 includes a first direction guide 71a, a first direction drive member 71b, a vertical direction guide 71c, and a vertical direction drive member 71d; The guide 71c is slidably provided with the cup gripper 79 of the first transfer component 71, and is driven by the vertical direction guide 71c, so that the cup gripper 79 can move in the vertical direction along the vertical direction guide 71c; The direction guide 71a is slidably provided with a vertical direction guide 71c, and driven by the first direction driving member 71b, the vertical direction guide 71c can move in the first direction along the first direction guide 71a, thereby driving The cup gripper 79 of the first transfer component 71 also moves in the first direction. With this structure, the cup gripper 79 of the first transfer component 71 can be moved in the first direction and the vertical direction. . In some specific embodiments, the first direction guide 71a may include a first guide rail; the first direction driving component 71b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the vertical direction guide 71c may be fixedly connected to the first timing belt; similarly, the vertical direction guide 71c may include a vertical guide rail; the vertical direction drive member 71d may It includes an elevating stepping motor and a vertical screw rod. A mounting plate can be threaded on the vertical screw rod for mounting the cup gripper 79 of the first transfer component 71. In some embodiments, the first transfer component 71 may further include a first bracket 71f for installing the above-mentioned first direction guide 71a.
一些实施例中,第一转运部件71的抓杯手79沿第二方向例如图中X方向抓取例如加样位10a上的反应杯,这样第一转运部件71在抓取反应杯时不会影响样本分注部件30向反应杯排入样本,从而可以使得第一转运部件71在抓取反应杯的同时,样本分注部件30完成反应杯的加样,节省了时间,提高了测量速度和效率。In some embodiments, the cup gripper 79 of the first transport component 71 grabs, for example, the cuvette on the sample loading position 10a in the second direction, such as the X direction in the figure, so that the first transport component 71 does not grab the cuvette. Affect the sample dispensing part 30 to discharge the sample into the reaction cup, so that the first transfer part 71 can grasp the reaction cup while the sample dispensing part 30 completes the sample addition of the reaction cup, which saves time and improves the measurement speed and measurement speed. effectiveness.
以上就是第一转运部件71的一些说明。The above is some descriptions of the first transfer component 71.
第二转运部件73用于将第一缓存中转位77的反应杯运送到反应部件51,以及将反应部件51中试样孵育完成的反应杯运送到第二缓存中转位78。一些实施例中,第二转运部件73通过沿第一方向例如图中方向的直线运动和第二方向例如图中X方向的直线运动,将第一缓存中转位77的反应杯运送到反应部件51,以及将反应部件51中试样孵育完成的反应杯运送到第二缓存中转位78。由于第二转运部件73走直线运动进行反应杯运动,相对降低了反应杯运送过程中所占用的样 本分析装置的体积,有利于样本分析装置的小型化设计。The second transfer component 73 is used to transfer the cuvettes indexed 77 in the first buffer to the reaction part 51, and to transfer the reaction cups after the sample incubation in the reaction part 51 is completed to the index 78 in the second buffer. In some embodiments, the second transfer component 73 transports the cuvette of the index 77 in the first buffer to the reaction component 51 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. , And transport the reaction cup in which the sample incubation is completed in the reaction part 51 to the index 78 in the second buffer. Since the second transfer member 73 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.
具体的转运过程中,第二转运部件先73可以先将第一缓存中转位77的反应杯运送到孵育中转位51a,试剂分注部件60吸取试剂并排放到位于孵育中转位51a的反应杯中,第二转运部件73再将孵育中转位51a的反应杯运送到反应部件51。In the specific transfer process, the second transfer component 73 can first transport the reaction cup of the first buffer index 77 to the incubation index 51a, and the reagent dispensing part 60 sucks the reagent and discharges it into the reaction cup located in the incubation index 51a. , The second transfer part 73 then transfers the cuvette with the transposition 51a during the incubation to the reaction part 51.
一些实施例中,第二转运部件73可以沿第一方向(例如图中Y方向)、第二方向(例如图中X方向)和竖直方向(例如垂直于图纸的方向)移动,因此第二转运部件73的驱动部件可以是一个三维的驱动部件,用于驱动第二转运部件73的抓杯手79沿第一方向、第二方向和竖直方向移动。请参照图12(c),一些实施例中,第二转运部件73包括第一方向导向件73a、第一方向驱动部件73b、第二方向导向件73c、第二方向驱动部件73d、竖直方向导向件73e和竖直方向驱动部件73f;竖直方向导向件73e上滑动设置有第二转运部件73的抓杯手79,并通过竖直方向导向件73f的驱动,使得抓杯手79可以沿竖直方向导向件73e在竖直方向移动;第二方向导向件73c上滑动设置有竖直方向导向件73e,并通过第二方向驱动部件73d的驱动,使得竖直方向导向件73e可以沿第二方向导向件73c在第二方向上移动,从而带动第二转运部件73的抓杯手79也沿第二方向上移动;第一方向导向件73a上滑动设置有第二方向导向件73c,并通过第一方向驱动部件73b的驱动,使得第二方向导向件73c可以沿第一方向导向件73a在第一方向上移动,从而带动第二方向导向件73c也沿第一方向上移动,从而可以带动第二方向导向件73c上的竖直方向导向件73e在第一方向上移动,从而可以带动竖直方向导向件73e上的第二转运部件73的抓杯手79也沿第一方向移动;通过这样的结构,就可以实现第二转运部件73的抓杯手79在第一方向、第二方向和竖直方向这三维方向上移动。具体的一些实施例中,第一方向导向件73a可以包括第一导轨;第一方向驱动部件73b可以包括第一步进电机、第一从动轮和第一同步带,第一同步带套接于第一步进电机和第一从动轮之间,第二方向导向件73c可以与第一同步带固定连接;类似地,第二方向导向件73c可以包括第二导轨;第二方向驱动部件73d可以包括第二步进电机、第二从动轮和第二同步带,第二同步带套接于第二步进电机和第二从动轮之间,竖直方向导向件73e可以与第二同步带固定连接;类似地,竖直方向导向件73e可以包括竖直导轨;竖直方向驱动部件73f可以包括升降 步进电机和竖直丝杆,竖直丝杆上可以螺纹套设有一个安装板,用于安装第二转运部件73的抓杯手79。一些实施例中,第二转运部件73还可以包括第二支架73g,用于安装上述的第一方向导向件73a。In some embodiments, the second transfer member 73 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing), so the second The driving part of the transporting part 73 may be a three-dimensional driving part for driving the cup gripper 79 of the second transporting part 73 to move in the first direction, the second direction and the vertical direction. 12(c), in some embodiments, the second transfer member 73 includes a first direction guide 73a, a first direction driving member 73b, a second direction guide 73c, a second direction driving member 73d, and a vertical direction. The guide member 73e and the vertical direction driving member 73f; the vertical direction guide member 73e is slidably provided with the cup gripper 79 of the second transfer member 73, and the vertical direction guide member 73f is driven so that the cup gripper 79 can move along The vertical direction guide 73e moves in the vertical direction; the second direction guide 73c is slidably provided with a vertical direction guide 73e, and is driven by the second direction driving member 73d, so that the vertical direction guide 73e can move along the first direction. The two-direction guide 73c moves in the second direction, thereby driving the cup gripper 79 of the second transfer member 73 to also move in the second direction; the first-direction guide 73a is slidably provided with a second-direction guide 73c, and Driven by the first-direction driving member 73b, the second-direction guide 73c can move in the first direction along the first-direction guide 73a, thereby driving the second-direction guide 73c to also move in the first direction. Drive the vertical direction guide member 73e on the second direction guide member 73c to move in the first direction, so that the cup gripper 79 of the second transfer member 73 on the vertical direction guide member 73e can also move in the first direction; With such a structure, the cup gripper 79 of the second transport member 73 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction. In some specific embodiments, the first direction guide 73a may include a first guide rail; the first direction driving component 73b may include a first stepper motor, a first driven wheel, and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 73c can be fixedly connected to the first timing belt; similarly, the second direction guide 73c can include a second guide rail; the second direction drive part 73d can be It includes a second stepping motor, a second driven wheel and a second timing belt. The second timing belt is sleeved between the second stepping motor and the second driven wheel. The vertical direction guide 73e can be fixed to the second timing belt. Similarly, the vertical direction guide 73e can include a vertical guide rail; the vertical direction driving part 73f can include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The cup gripper 79 is installed on the second transfer component 73. In some embodiments, the second transfer component 73 may further include a second bracket 73g for installing the above-mentioned first direction guide 73a.
一些实施例中,第二转运部件73的抓杯手79沿第二方向例如图中X方向抓取反应杯,这样第二转运部件71在抓取反应杯时不会影响试剂分注部件60例如第一试剂分注部件向反应杯加入试剂,从而可以使得第二转运部件73在抓取反应杯的同时,试剂分注部件60完成反应杯的加试剂,节省了时间,提高了测量速度和效率。一些实施例中,第二转运部件73抓取反应杯的方向与第一组试剂针直线运动的方向大于90度,这样的话,第二转运部件73抓取反应杯的动作与第一组试剂针的加试剂动作之间就更不容易发生冲突,两者可以非常合理地独立和并行进行相应动作。In some embodiments, the gripper 79 of the second transfer component 73 grips the cuvette in a second direction, such as the X direction in the figure, so that the second transfer component 71 will not affect the reagent dispensing component 60 when gripping the cuvette. The first reagent dispensing part adds reagents to the reaction cup, so that the second transfer part 73 can grasp the reaction cup while the reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency. . In some embodiments, the direction in which the second transfer component 73 grabs the reaction cup and the direction of the linear movement of the first set of reagent needles are greater than 90 degrees. In this case, the second transfer component 73 grabs the reaction cup and the first set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.
一些实施例中,第二转运部件73将反应杯从孵育中转位51a运送到反应部件51的过程中,还对反应杯中的试样进行混匀。例如第二转运部件73将加样完成的反应杯从第一缓存中转位77转运并放置在孵育中转位51a后,试剂分注部件60对孵育中转位51a上的反应杯接着加入试剂例如第一试剂,第二转运部件73则再拿起加试剂完成的反应杯,并进行混匀,然后再转运到反应部件51中;具体地,第二转运部件73可以通过驱动部件71b驱动抓杯手79快速地晃动来实现对抓杯手79所抓取的反应杯中的试样进行混匀。第二转运部件73兼具有混匀功能,使得样本分析装置不需要再设置独立的混匀机构,使得样本分析装置结构更加紧凑,同时也降低了成本;另外,第二转运部件73在抓取反应杯准备转运时进行混匀,也节省了时间,不用特意先将反应杯调度到相应的混匀机构进行混匀。In some embodiments, the second transfer component 73 transports the reaction cup from the incubation position 51a to the reaction component 51, and also mixes the sample in the reaction cup. For example, the second transfer component 73 transfers the sample-loaded reaction cup from the first buffer to the transposition 77 and places it in the incubation transposition 51a. The reagent dispensing component 60 then adds reagents to the reaction cup on the transposition 51a in the incubation. For reagents, the second transfer component 73 picks up the reaction cup with reagents added, mixes it, and then transfers it to the reaction component 51; specifically, the second transfer component 73 can drive the cup gripper 79 through the drive component 71b Shake quickly to achieve mixing of the sample in the reaction cup gripped by the cup gripper 79. The second transfer component 73 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the second transfer component 73 is grabbing Mixing the cuvette when it is ready for transfer also saves time, and there is no need to dispatch the cuvette to the corresponding mixing mechanism for mixing.
以上就是第二转运部件73的一些说明。第二转运部件73通过沿第一方向和第二方向的直线运动,可以并实现了在第一缓存中转位77、孵育中转位51a、反应部件51和第二缓存中转位78之间转运反应杯。The above are some descriptions of the second transfer component 73. The second transfer part 73 can and realize the transfer of the cuvette between the first buffer and the incubation part 51a, the reaction part 51 and the second buffer part 78 by linear movement along the first direction and the second direction. .
第三转运部件75用于将第二缓存中转位78的反应杯运送到测定部件52。一些实施例中,第三转运部件75通过沿第一方向例如图中方向的直线运动和第二方向例如图中X方向的直线运动,将第二缓存中转位78的反应杯运送到测定部件52。由于第三转运部件75走直线运动进行反应杯运动,相对降低了反应杯运送过程 中所占用的样本分析装置的体积,有利于样本分析装置的小型化设计。The third transfer part 75 is used to transfer the cuvettes indexed 78 in the second buffer to the measurement part 52. In some embodiments, the third transfer component 75 transports the cuvette of the index 78 in the second buffer to the measurement component 52 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. . Since the third transfer member 75 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.
具体的转运过程中,第三转运部件75可以先将第二缓存中转位78的反应杯运送到测定中转位52a,试剂分注部件60吸取试剂并排放到位于测定中转位52a的反应杯中,第三转运部件75再将测定中转位75a的反应杯运送到测定部件52。一些实施例中,在第三转运部件75将反应杯由第二缓存中转位78转运到测定中转位52a时,第三转运部件75可以不把反应杯放置在测定中转位52a,而是仍然抓取着反应杯,在这种情况下,试剂分注部件60吸取试剂并排放到反应杯,这样使得反应杯由第二缓存中转位78最终进入到测定部件52中的时间减少,提高了测试速度。During the specific transfer process, the third transfer component 75 may first transport the cuvette of the index 78 in the second buffer to the index 52a in the measurement, and the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette at the index 52a in the measurement. The third transfer part 75 then transfers the cuvette with the index 75 a during the measurement to the measurement part 52. In some embodiments, when the third transfer component 75 transfers the cuvette from the second buffer translocation 78 to the measurement translocation 52a, the third transfer component 75 may not place the cuvette in the measurement translocation 52a, but still grasp it. Take the cuvette. In this case, the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette, so that the time for the cuvette to be transposed from the second buffer 78 and finally enter the measuring part 52 is reduced, and the test speed is increased. .
一些实施例中,第三转运部件75可以沿第一方向(例如图中Y方向)、第二方向(例如图中X方向)和竖直方向(例如垂直于图纸的方向)移动,因此第三转运部件75的驱动部件可以是一个三维的驱动部件,用于驱动第三转运部件75的抓杯手79沿第一方向、第二方向和竖直方向移动。请参照图12(d),一些实施例中,第三转运部件75包括第一方向导向件75a、第一方向驱动部件75b、第二方向导向件75c、第二方向驱动部件75d、竖直方向导向件75e和竖直方向驱动部件75f;竖直方向导向件75e上滑动设置有第三转运部件75的抓杯手79,并通过竖直方向导向件75f的驱动,使得抓杯手79可以沿竖直方向导向件75e在竖直方向移动;第二方向导向件75c上滑动设置有竖直方向导向件75e,并通过第二方向驱动部件75d的驱动,使得竖直方向导向件75e可以沿第二方向导向件75c在第二方向上移动,从而带动第三转运部件75的抓杯手79也沿第二方向上移动;第一方向导向件75a上滑动设置有第二方向导向件75c,并通过第一方向驱动部件75b的驱动,使得第二方向导向件75c可以沿第一方向导向件75a在第一方向上移动,从而带动第二方向导向件75c也沿第一方向上移动,从而可以带动第二方向导向件75c上的竖直方向导向件75e在第一方向上移动,从而可以带动竖直方向导向件75e上的第三转运部件75的抓杯手79也沿第一方向移动;通过这样的结构,就可以实现第三转运部件75的抓杯手79在第一方向、第二方向和竖直方向这三维方向上移动。具体的一些实施例中,第一方向导向件75a可以包括第一导轨;第一方向驱动部件75b可以包括第一步进电机、第一从动轮和第一同步带,第一同步带套接 于第一步进电机和第一从动轮之间,第二方向导向件75c可以与第一同步带固定连接;类似地,第二方向导向件75c可以包括第二导轨;第二方向驱动部件75d可以包括第二步进电机、第二从动轮和第二同步带,第二同步带套接于第二步进电机和第二从动轮之间,竖直方向导向件75e可以与第二同步带固定连接;类似地,竖直方向导向件75e可以包括竖直导轨;竖直方向驱动部件75f可以包括升降步进电机和竖直丝杆,竖直丝杆上可以螺纹套设有一个安装板,用于安装第三转运部件75的抓杯手79。一些实施例中,第三转运部件75还可以包括第二支架75g,用于安装上述的第一方向导向件75a。In some embodiments, the third transfer member 75 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing). The driving part of the transfer part 75 may be a three-dimensional driving part for driving the cup gripper 79 of the third transfer part 75 to move in the first direction, the second direction and the vertical direction. 12(d), in some embodiments, the third transfer member 75 includes a first direction guide 75a, a first direction drive member 75b, a second direction guide 75c, a second direction drive member 75d, and a vertical direction The guide member 75e and the vertical direction driving member 75f; the vertical direction guide member 75e is slidably provided with the cup gripper 79 of the third transfer member 75, and the vertical direction guide member 75f is driven so that the cup gripper 79 can move along The vertical direction guide 75e moves in the vertical direction; the second direction guide 75c is slidably provided with a vertical direction guide 75e, and is driven by the second direction driving member 75d, so that the vertical direction guide 75e can move along the first direction. The two-direction guide 75c moves in the second direction, thereby driving the cup gripper 79 of the third transfer member 75 to also move in the second direction; the first-direction guide 75a is slidably provided with a second-direction guide 75c, and Driven by the first direction driving member 75b, the second direction guide 75c can move in the first direction along the first direction guide 75a, thereby driving the second direction guide 75c to also move in the first direction, so that the second direction guide 75c can also move in the first direction. Drive the vertical direction guide member 75e on the second direction guide member 75c to move in the first direction, so that the cup gripper 79 of the third transfer member 75 on the vertical direction guide member 75e can also move in the first direction; With such a structure, the cup gripper 79 of the third transport member 75 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction. In some specific embodiments, the first direction guide 75a may include a first guide rail; the first direction driving component 75b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 75c can be fixedly connected to the first timing belt; similarly, the second direction guide 75c can include a second guide rail; the second direction drive member 75d can Including a second stepping motor, a second driven wheel and a second timing belt, the second timing belt is sleeved between the second stepping motor and the second driven wheel, the vertical direction guide 75e can be fixed with the second timing belt Similarly, the vertical direction guide 75e may include a vertical guide rail; the vertical direction driving part 75f may include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The gripper 79 for installing the third transfer component 75. In some embodiments, the third transfer member 75 may further include a second bracket 75g for installing the above-mentioned first direction guide 75a.
一些实施例中,第三转运部件75的抓杯手79沿第一方向例如图中Y方向抓取反应杯,这样第三转运部件75在抓取反应杯的同时——即使第三转运部件75在整个加试剂过程都抓取着反应杯,也不会影响试剂分注部件60例如第二试剂分注部件向反应杯加入试剂,从而可以使得第三转运部件75在抓取反应杯的同时,试剂分注部件60完成反应杯的加试剂,节省了时间,提高了测量速度和效率。一些实施例中,第三转运部件75抓取反应杯的方向与第二组试剂针直线运动的方向大于90度,这样的话,第三转运部件75抓取反应杯的动作与第二组试剂针的加试剂动作之间就更不容易发生冲突,两者可以非常合理地独立和并行进行相应动作。In some embodiments, the gripper 79 of the third transfer component 75 grips the cuvette in the first direction, such as the Y direction in the figure, so that the third transfer component 75 grasps the cuvette at the same time—even if the third transfer component 75 The reaction cup is grasped during the entire reagent addition process, and it will not affect the reagent dispensing part 60, such as the second reagent dispensing part, to add reagents to the reaction cup, so that the third transfer part 75 can grasp the reaction cup at the same time. The reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency. In some embodiments, the direction in which the third transfer component 75 grabs the cuvette and the direction of the linear movement of the second set of reagent needles are greater than 90 degrees. In this case, the third transfer component 75 grabs the reaction cup and the second set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.
一些实施例中,第三转运部件75将反应杯从测定中转位52a运送到测定部件52的过程中对反应杯中的试样进行混匀。例如第三转运部件75将反应杯从第二缓存中转位78转运到测定中转位52a时——一些实施例中,第三转运部件75在将反应杯转运到测定中转位52a,可以不放下反应杯,而下仍然抓取着反应杯;试剂分注部件60对测定中转位52a的反应杯接着加入试剂例如第二试剂,第三转运部件75则再对所抓取的反应杯中的试样进行混匀,然后再转运到测定部件52中;具体地,第三转运部件75可以通过驱动部件71b驱动抓杯手79快速地晃动来实现对抓杯手79所抓取的反应杯中的试样进行混匀。第三转运部件75兼具有混匀功能,使得样本分析装置不需要再设置独立的混匀机构,使得样本分析装置结构更加紧凑,同时也降低了成本;另外,由第三转运部件75在原本的转运路径上例如测定中转位52a对反应杯进行混匀,也节省了时间,不用特意先将反应杯调 度到相应的混匀机构进行混匀。In some embodiments, the third transport component 75 mixes the sample in the cuvette during the process of transporting the cuvette from the in-measuring transposition 52a to the measuring component 52. For example, when the third transfer unit 75 transfers the cuvette from the second buffer to the mid-measurement translocation 52a-in some embodiments, the third transfer unit 75 transfers the cuvette to the mid-measurement translocation 52a without dropping the reaction. The cuvette is still grasped underneath; the reagent dispensing part 60 then adds reagents such as the second reagent to the cuvette at 52a during the measurement, and the third transfer part 75 then adds the sample to the cuvette that was grasped. Perform mixing, and then transfer to the measuring part 52; specifically, the third transfer part 75 can drive the cup grasping hand 79 to shake quickly through the driving part 71b to realize the test in the reaction cup grasped by the cup grasping hand 79. Mix the same. The third transfer component 75 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the third transfer component 75 For example, the transposition 52a is used to mix the reaction cup on the transport path in the measurement, which also saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
一些例子中,第三转运部件75在将反应杯调度到测定部件52后,还可以抓取测定部件52中已经测定完成的反应杯,然后转运到第二抛杯位10d进行抛杯处理,一些实施例中,第二抛杯位10d可以设置在第二缓存中转位78的附近,或者设置在测定部件52与第二缓存中转位78之间,这样第三转运部件75在从测定部件52向第二缓存中转位78以转运第二缓存中转位78上的反应杯时,可以顺便对测定部件52上的测定完成的反应杯进行抛杯处理,从而节省时间,提高了测试效率。In some examples, after the third transfer component 75 dispatches the reaction cup to the measurement component 52, it can also grab the measured reaction cup in the measurement component 52, and then transfer it to the second throwing cup position 10d for cup throwing. In an embodiment, the second cup throwing position 10d can be arranged near the index 78 in the second buffer, or between the measuring part 52 and the index 78 in the second buffer, so that the third transfer part 75 moves from the measuring part 52 to the index 78. When the index 78 in the second buffer is used to transfer the cuvette on the index 78 in the second buffer, the measured cuvette on the measuring component 52 can be thrown away by the way, thereby saving time and improving test efficiency.
以上就是第三转运部件75的一些说明。第三转运部件75通过沿第一方向和第二方向的直线运动,可以并实现了在第二缓存中转位78、测定中转位52a、测定部件52甚至第二抛杯位10d之间转运反应杯。The above are some descriptions of the third transfer component 75. The third transfer part 75 can and realize the transfer of the reaction cup between the second buffer 78, the measurement 52a, the measurement part 52 and even the second throwing position 10d by linear movement in the first direction and the second direction. .
以上就是本发明一些实施例的调度部件70的说明,本申请通过三个转运部件即第一转运部件71、第二转运部件73和第三转运部件75来完成反应杯的快速转运,反应杯的调度路径简单和直接,有利于样本分析装置的提速;再配合两个缓存中转位即第一缓存中转位77和第二缓存中转位78来完成这三个转运部件之间的过渡,结构上也简单和紧凑。The above is the description of the scheduling component 70 of some embodiments of the present invention. The application uses three transport components, namely the first transport component 71, the second transport component 73 and the third transport component 75 to complete the rapid transport of the cuvette. The scheduling path is simple and direct, which is conducive to the speed-up of the sample analysis device; in conjunction with the two buffer transfer positions, namely the first buffer transfer position 77 and the second buffer transfer position 78, the transition between the three transfer components is completed, and the structure is also Simple and compact.
以上就是本发明一些实施例中所公开的样本分析装置。可以理解地,本发明所公开的样本分析装置还可以包括一些其他结构,例如清洗部件80和/或处理器90等,下面结合图15和图16来具体来说明。The above is the sample analysis device disclosed in some embodiments of the present invention. It is understandable that the sample analysis device disclosed in the present invention may also include some other structures, such as the cleaning component 80 and/or the processor 90, etc., which will be specifically described below with reference to FIG. 15 and FIG. 16.
清洗部件80用于清洗试剂针,例如清洗第一试剂针和第二试剂针等。具体地,清洗部件80可以包括多个清洗池81,清洗池81的数量可以与试剂针的数量相同,例如当样本分析装置包括第一试剂分注部件和第二试剂分注部件,每个试剂分注部件又都包括两根试剂针时,则清洗池的数量可以为四个。可以在每个试剂针的直线运动的轨迹上设置一个清洗池,用于对试剂针进行清洗。请参照图16,清洗部件80用于对试剂针进行清洗,具体地,可以是通过清洗液对试剂针进行内壁和外壁的清洗。清洗部件80包括图中的清洗池、管路和设置于管路上的开关阀等。试剂针的末端可以连接一管路,该管路通过开关阀SV01来开启和关闭,当开关阀SV01开启时,清洗液可以通过管路到达试剂针的末端,流经试剂 针的内壁,并从试剂针的前端流出,完成清洗液对试剂针的内壁清洗。清洗室也连接一管路,该管路通过开关阀SV02来开启和关闭,当开关阀SV02开启时,清洗液可以通过管路到达清洗室,并从清洗室内壁喷出到试剂针的外壁,完成清洗液对试剂针的外壁清洗。清洁室的下端通过管路连接一废液吸入阀SV03,废液吸入阀SV03开启时,清洗后的废液经过清洗室的下端流出。具体清洗时,试剂针来到清洗室的上方,再向下运动将试剂针的部分(至少包括吸试剂时接触到试剂液面的那部分针体)伸入到清洗室内,以使得清洗室内喷出的清洗液可以清洗到试剂针接触到液面的那部分针体,完成对试剂针的清洗。各清洗池81可以共用同一套液路来提供用于清洗试剂针的清洗液。The cleaning component 80 is used for cleaning the reagent needles, for example, cleaning the first reagent needle and the second reagent needle. Specifically, the cleaning component 80 may include multiple cleaning tanks 81, and the number of cleaning tanks 81 may be the same as the number of reagent needles. For example, when the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component, each reagent When the dispensing parts both include two reagent needles, the number of cleaning tanks can be four. A washing tank can be set on the linear movement track of each reagent needle for cleaning the reagent needle. Referring to FIG. 16, the cleaning component 80 is used to clean the reagent needle. Specifically, the inner wall and the outer wall of the reagent needle may be cleaned by a cleaning solution. The cleaning component 80 includes a cleaning tank, a pipeline, an on-off valve arranged on the pipeline, and the like in the figure. The end of the reagent needle can be connected to a pipeline, which is opened and closed by the on-off valve SV01. When the on-off valve SV01 is opened, the cleaning fluid can reach the end of the reagent needle through the pipeline, flow through the inner wall of the reagent needle, and from The front end of the reagent needle flows out to complete the cleaning of the inner wall of the reagent needle by the cleaning solution. The cleaning chamber is also connected to a pipeline, which is opened and closed by the on-off valve SV02. When the on-off valve SV02 is opened, the cleaning fluid can reach the cleaning chamber through the pipeline, and spray from the cleaning chamber wall to the outer wall of the reagent needle. Finish cleaning the outer wall of the reagent needle with the cleaning solution. The lower end of the cleaning chamber is connected to a waste liquid suction valve SV03 through a pipeline. When the waste liquid suction valve SV03 is opened, the cleaned waste liquid flows out through the lower end of the cleaning chamber. During specific cleaning, the reagent needle comes to the top of the cleaning chamber, and then moves downward to extend the part of the reagent needle (at least the part of the needle that touches the reagent liquid surface when sucking the reagent) into the cleaning chamber, so that the cleaning chamber sprays. The cleaning solution can be used to clean the part of the needle body where the reagent needle touches the liquid surface to complete the cleaning of the reagent needle. Each cleaning tank 81 can share the same set of liquid paths to provide cleaning liquid for cleaning the reagent needles.
下面对样本分析装置的一些具体工作流程进行说明。The following describes some specific working procedures of the sample analysis device.
一些实施例中的样本分析装置可以是这样来工作的。The sample analysis device in some embodiments may work in this way.
反应杯装载部件10供应并运载空反应杯。例如反应杯装载部件10可以将空的反应杯加载到预定位置,该预定位置可以被作为加样位。样本部件20例如进样部件21将承载有样本的样本架调度到吸样位。样本分注部件30从吸样位吸取样本并分注到反应杯中,例如样本分注部件从吸样位吸取样后排放到位于加样位上的反应杯,以完成加样。The cuvette loading part 10 supplies and carries empty cuvettes. For example, the cuvette loading part 10 may load an empty cuvette to a predetermined position, and the predetermined position may be used as a sample loading position. The sample component 20, such as the sample injection component 21, dispatches the sample rack carrying the sample to the sample suction position. The sample dispensing component 30 draws samples from the sample suction position and dispenses them into the reaction cup. For example, the sample dispensing component draws samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.
试剂承载部件60的驱动部件驱动试剂承载部件60旋转,以使得承载有第一试剂的试剂容器位于第一吸试剂位。第一试剂分注部件60上的两个试剂针61至少其中之一通过第一吸试剂位吸取试剂容器中的第一试剂,并在该第一吸试剂位和反应部件51的加试剂中转位之间作直线运动,以向反应部件51的加试剂中转位的反应杯分注第一试剂。反应部件51的加试剂中转位可以是本文提及的孵育中转位51a。一些实施例中,第一试剂分注部件60的两个第一试剂针61相互独立地在第一吸试剂位和反应部件51的加试剂中转位之间作直线运动。这样第一试剂分注部件60的两个第一试剂针61就可以分别地独立地——例如交替地完成对反应部件51的加试剂中转位上的反应杯进行加入第一试剂的操作,提高了测试速度和效率。一些具体的实施例中,第一试剂分注部件60中的每一第一试剂针61都依次进行多个预设动作以完成加第一试剂操作,且两两第一试剂针61之间的所述多个预设动作中,至少有一个对应的预设动作在时序上不交叠。这样的话 ,第一试剂分注部件60的两根试剂针61可以尽量避免少占用公共资源,使得提供相应公共资源的部件的数量可以减少,从而样本分析装置可以更加紧凑;而且这样来安排两根第一试剂针61的动作时序,也尽量避免了他们之间的互相影响,这对于样本分析装置的提速十分有利。The driving part of the reagent carrying part 60 drives the reagent carrying part 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing part 60 sucks the first reagent in the reagent container through the first reagent suction position, and is indexed in the first reagent suction position and the reagent addition of the reaction part 51 A linear motion is made between them to dispense the first reagent into the reaction cup indexed in the reagent addition of the reaction part 51. The transposition in the reagent addition of the reaction part 51 may be the transposition 51a in the incubation mentioned herein. In some embodiments, the two first reagent needles 61 of the first reagent dispensing part 60 independently move linearly between the first reagent suction position and the reagent adding position of the reaction part 51. In this way, the two first reagent needles 61 of the first reagent dispensing part 60 can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part 51, which improves Improve the test speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the first reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles 61 of the first reagent dispensing part 60 can avoid occupying public resources as much as possible, so that the number of parts providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged. The action sequence of the first reagent needle 61 also avoids their mutual influence as much as possible, which is very beneficial to the speed-up of the sample analysis device.
调度部件70将完成第一试剂分注的反应杯调度到反应部件51进行孵育,并将孵育完成后的反应杯调度至测定部件52的加试剂中转位。测定部件52的加试剂中转位可以是本文提及的测定中转位52a。The scheduling component 70 schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component 51 for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measuring component 52 for indexing. The mid-reagent transposition of the measuring part 52 may be the mid-measure transposition 52a mentioned herein.
试剂承载部件40旋转,以使得承载有第二试剂的试剂容器位于第二吸试剂位。第二试剂分注部件60上的两个试剂针至少其中之一通过第二吸试剂位吸取试剂容器中的第二试剂,并在该第二吸试剂位和测定部件的加试剂中转位之间作直线运动,以向测定部件52的加试剂中转位的反应杯分注第二试剂。一些实施例中,第二试剂分注部件60的两个第二试剂针61相互独立地在第二吸试剂位和测定部件52的加试剂中转位之间作直线运动。这样第二试剂分注部件60的两个第二试剂针61就可以分别地独立地——例如交替地完成对测定部件52的加试剂中转位上的反应杯进行加入第二试剂的操作,提高了测试速度和效率。一些具体的实施例中,第二试剂分注部件60中的每一第二试剂针61都依次进行多个预设动作以完成加第二试剂操作,且两两第二试剂针61之间的所述多个预设动作中,至少有一个对应的预设动作在时序上不交叠。这样的话,第二试剂分注部件60的两根试剂针61可以尽量避免少占用公共资源,使得提供相应公共资源的部件的数量可以减少,从而样本分析装置可以更加紧凑;而且这样来安排两根第二试剂针的动作时序,也尽量避免了他们之间的互相影响,这对于样本分析装置的提速十分有利。The reagent carrying member 40 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing part 60 sucks the second reagent in the reagent container through the second reagent suction position, and acts between the second reagent suction position and the reagent adding position of the measuring part. It moves linearly to dispense the second reagent into the reaction cup indexed in the reagent addition of the measuring part 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing part 60 independently move linearly between the second reagent suction position and the indexing position of the measuring part 52 during reagent addition. In this way, the two second reagent needles 61 of the second reagent dispensing part 60 can be separately and independently-for example, alternately completing the operation of adding the second reagent to the reaction cup on the transposition in the reagent addition of the measuring part 52, which improves Improve the test speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles 61 of the second reagent dispensing part 60 can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged. The action timing of the second reagent needle also minimizes their mutual influence, which is very beneficial to the speed-up of the sample analysis device.
调度部件70将完成第二试剂分注的反应杯调度到测定部件52进行项目检测,并将检测完成后的反应杯调度到废弃回收装置中——例如本文提及的第二抛杯位。The scheduling component 70 schedules the reaction cup that has completed the dispensing of the second reagent to the measurement component 52 for item detection, and schedules the reaction cup after the detection to the waste recovery device—for example, the second throwing cup position mentioned herein.
本发明一些实施例中还公开了一种样本分析方法。请参照图17,一些实施例中,样本分析方法包括以下步骤:A sample analysis method is also disclosed in some embodiments of the present invention. Referring to FIG. 17, in some embodiments, the sample analysis method includes the following steps:
步骤100,即反应杯加载步骤,控制反应杯装载部件供应并运载空反应杯。例 如反应杯装载部件可以将空的反应杯加载到预定位置,该预定位置可以被作为加样位。 Step 100, namely the reaction cup loading step, controls the supply of the reaction cup loading parts and carries the empty reaction cup. For example, the cuvette loading part can load an empty cuvette to a predetermined position, and the predetermined position can be used as a sample loading position.
步骤110,即样本进给步骤,控制样本部件例如进样部件将承载有样本的样本架调度到吸样位。 Step 110, that is, the sample feeding step, controls the sample component, such as the sample injection component, to dispatch the sample rack carrying the sample to the sample suction position.
步骤120,即样本分注步骤,控制样本分注部件从吸样位吸取样本并分注到反应杯中。例如样本分注部件从吸样位吸取样后排放到位于加样位上的反应杯,以完成加样。In step 120, the sample dispensing step, the sample dispensing component is controlled to draw a sample from the sample suction position and dispense it into the reaction cup. For example, the sample dispensing component sucks samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.
通过以上步骤100到120,即完成了加样。Through the above steps 100 to 120, the sample addition is completed.
步骤130,即第一试剂分注步骤,控制试剂承载部件的驱动部件驱动试剂承载部件旋转,以使得承载有第一试剂的试剂容器位于第一吸试剂位;控制第一试剂分注部件上的两个试剂针至少其中之一通过第一吸试剂位吸取试剂容器中的第一试剂,并在该第一吸试剂位和反应部件的加试剂中转位之间作直线运动,以向反应部件的加试剂中转位的反应杯分注第一试剂。在步骤130中反应部件的加试剂中转位可以是本文提及的孵育中转位。In step 130, the first reagent dispensing step, the driving part of the reagent carrying part is controlled to drive the reagent carrying part to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position; At least one of the two reagent needles sucks the first reagent in the reagent container through the first reagent sucking position, and moves linearly between the first reagent sucking position and the indexing position of the reagent in the reaction part to add to the reaction part. The transposed reaction cup among the reagents dispenses the first reagent. The translocation in the reagent addition of the reaction component in step 130 may be the translocation in the incubation mentioned herein.
一些实施例中,步骤130控制所述第一试剂分注部件的两个第一试剂针相互独立地在第一吸试剂位和反应部件的加试剂中转位之间作直线运动。这样第一试剂分注部件的两个第一试剂针就可以分别地独立地——例如交替地完成对反应部件的加试剂中转位上的反应杯进行加入第一试剂的操作,提高了测试速度和效率。一些具体的实施例中,步骤130控制第一试剂分注部件中的每一第一试剂针都依次进行多个预设动作以完成加第一试剂操作,且两两第一试剂针之间的所述多个预设动作中,至少有一个对应的预设动作在时序上不交叠。这样的话,第一试剂分注部件的两根试剂针可以尽量避免少占用公共资源,使得提供相应公共资源的部件的数量可以减少,从而样本分析装置可以更加紧凑;而且这样来安排两根第一试剂针的动作时序,也尽量避免了他们之间的互相影响,这对于样本分析装置的提速十分有利。应当说明的是,多个预设动作根据不同的测试需求不同,在一实施例中,多个预设动作包括以下4个:吸试剂动作、加热动作、排试剂动作和清洗动作。两两第一试剂针之间,4个动作至少有一个在时序上是不重叠的。In some embodiments, step 130 controls the two first reagent needles of the first reagent dispensing part to move linearly between the first reagent suction position and the reagent adding position of the reaction part independently of each other. In this way, the two first reagent needles of the first reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part, which improves the test speed And efficiency. In some specific embodiments, step 130 controls each first reagent needle in the first reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the two first reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles of the first reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two first reagent needles can be arranged. The action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device. It should be noted that multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between the two first reagent needles, at least one of the four actions does not overlap in time sequence.
通过步骤130完成了对加有样本的反应杯中加入第一试剂。Step 130 completes adding the first reagent to the reaction cup with the sample.
步骤140,即孵育步骤,控制调度部件将完成第一试剂分注的反应杯调度到反应部件进行孵育,并将孵育完成后的反应杯调度至测定部件的加试剂中转位。在步骤140中,测定部件的加试剂中转位可以是本文提及的测定中转位。 Step 140, that is, the incubation step, the control scheduling component schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measurement component for indexing. In step 140, the transposition in the reagent addition of the measurement component may be the transposition in the measurement mentioned herein.
步骤150,即第二试剂分注步骤,控制试剂承载部件旋转,以使得承载有第二试剂的试剂容器位于第二吸试剂位;控制第二试剂分注部件上的两个试剂针至少其中之一通过第二吸试剂位吸取试剂容器中的第二试剂,并在该第二吸试剂位和测定部件的加试剂中转位之间作直线运动,以向测定部件的加试剂中转位的反应杯分注第二试剂。 Step 150, that is, the second reagent dispensing step, control the rotation of the reagent carrying part so that the reagent container carrying the second reagent is located at the second reagent suction position; control at least one of the two reagent needles on the second reagent dispensing part A second reagent in the reagent container is sucked through the second reagent suction position, and a linear motion is made between the second reagent suction position and the indexing position of the reagent adding of the measuring part, so as to divide the reaction cup indexed into the reagent adding of the measuring part. Inject the second reagent.
一些实施例中,步骤150控制所述第二试剂分注部件的两个第二试剂针相互独立地在第二吸试剂位和测定部件的加试剂中转位之间作直线运动。这样第二试剂分注部件的两个第二试剂针就可以分别地独立地——例如交替地完成对测定部件的加试剂中转位上的反应杯进行加入第二试剂的操作,提高了测试速度和效率。一些具体的实施例中,步骤150控制第二试剂分注部件中的每一第二试剂针都依次进行多个预设动作以完成加第二试剂操作,且两两第二试剂针之间的所述多个预设动作中,至少有一个对应的预设动作在时序上不交叠。这样的话,第二试剂分注部件的两根试剂针可以尽量避免少占用公共资源,使得提供相应公共资源的部件的数量可以减少,从而样本分析装置可以更加紧凑;而且这样来安排两根第二试剂针的动作时序,也尽量避免了他们之间的互相影响,这对于样本分析装置的提速十分有利。应当说明的是,多个预设动作根据不同的测试需求不同,在一实施例中,多个预设动作包括以下4个:吸试剂动作、加热动作、排试剂动作和清洗动作。两两第二试剂针之间,4个动作至少有一个在时序上是不重叠的。In some embodiments, step 150 controls the two second reagent needles of the second reagent dispensing part to move linearly between the second reagent suction position and the reagent adding position of the measuring part independently of each other. In this way, the two second reagent needles of the second reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the second reagent to the reaction cup on the transposition in the reagent addition of the measuring part, which improves the test speed And efficiency. In some specific embodiments, step 150 controls each second reagent needle in the second reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles of the second reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two second reagent needles can be arranged. The action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device. It should be noted that multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between two second reagent needles, at least one of the four actions does not overlap in time sequence.
通过步骤150完成了对承载有孵育后的试剂的反应杯中继续加入第二试剂。Step 150 is completed to continue adding the second reagent to the reaction cup carrying the reagent after the incubation.
步骤160,即测定及回收步骤,控制调度部件将完成第二试剂分注的反应杯调度到测定部件进行项目检测,并将检测完成后的反应杯调度到废弃回收装置中——废弃回收装置可以具有例如本文提及的第二抛杯位。 Step 160, that is, the measurement and recovery step, the control and scheduling component will dispatch the reaction cup that has completed the dispensing of the second reagent to the measurement component for item detection, and dispatch the completed reaction cup to the waste recovery device-the waste recovery device can It has, for example, the second tossing position mentioned in this article.
以上是样本分析装置工作的一个整体流程。The above is an overall process of the work of the sample analysis device.
试剂分注部件60的工作流程安排对于完成检测速度提出了重要约束,各试剂针都需要完成吸样、加热、排样和清洗等动作。试剂承载部件40中用于保障试剂的活性,一般温度较低,例如16℃以下。试剂从试剂承载部件40取出后,需在较短时间内在试剂针内完成加热到37℃左右,以确保反应过程充分。通常情况下,试剂针的加热部件对试剂针所吸取的试剂的加热时间需要4~10秒。试剂针在不同检测项目的检测过程中,需要吸取不同类型的试剂,如进行凝血常规四项(PT/APTT/TT/FIB)项目检测中,需要从试剂承载部件40轮流吸取不同的第二试剂即触发试剂添加到反应杯中进行反应。因此,同一根试剂针在对不同项目试剂吸取时,需要进行普通清洗或者强洗清洗。为保证清洗效果,避免试剂间的携带污染影响检测结果的准确性,清洗时间一般需要2~8秒。而吸样和排样动作一般需要1.5~3s(包含水平运动到位时间)。因此,对于样本分析装置,例如单工作周期为8秒,在一个工作周期内完成上述这些吸样、加热、排样和清洗等全部动作,比较困难,整体检测速度被近降速。The work flow arrangement of the reagent dispensing component 60 puts forward important constraints on the completion of the detection speed, and each reagent needle needs to complete actions such as sample aspiration, heating, layout, and cleaning. The reagent carrying member 40 is used to ensure the activity of the reagent, and the temperature is generally lower, for example, below 16°C. After the reagent is taken out from the reagent carrying member 40, it needs to be heated in the reagent needle to about 37° C. in a short time to ensure a sufficient reaction process. Normally, the heating time of the reagent drawn by the reagent needle by the heating part of the reagent needle requires 4-10 seconds. The reagent needle needs to absorb different types of reagents in the detection process of different test items. For example, in the four routine coagulation (PT/APTT/TT/FIB) test items, different second reagents need to be taken in turn from the reagent carrying part 40 That is, the trigger reagent is added to the reaction cup to react. Therefore, the same reagent needle needs to be cleaned by ordinary cleaning or strong cleaning when sucking reagents from different items. In order to ensure the cleaning effect and avoid the contamination between the reagents that affects the accuracy of the test results, the cleaning time generally takes 2 to 8 seconds. The sample suction and layout actions generally take 1.5 to 3 seconds (including the time for the horizontal movement to reach the position). Therefore, for a sample analysis device, for example, a single working cycle is 8 seconds, and it is difficult to complete all the actions of aspirating, heating, setting out, and cleaning in one working cycle, and the overall detection speed is nearly reduced.
本发明一些实施例中对样本分析装置如何进行加试剂操作,即如何安排各试剂针的动作时序进行了设计,下面具体说明。In some embodiments of the present invention, how to add reagents to the sample analysis device, that is, how to arrange the action timing of each reagent needle, is designed, which will be described in detail below.
一些实施例中,处理器90用于控制同一组内每根试剂针都依次进行多个预设动作——例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作以完成加试剂操作,并且同一组内两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。例如第一试剂分注部件60中第一组试剂针包括两根第一试剂针,这两根第一试剂针之间的至少一个对应的预设动作在时序上不交叠,再例如第二试剂分注部件60中第二组试剂针包括两根第二试剂针,这两根第二试剂针之间的至少一个对应的预设动作在时序上不交叠。一些实施例中,可以为样本分析装置设置乒乓模式,当启用该模式时,即处理器90执行乒乓模式,以使得每组试剂针中的两两试剂针之间的至少一个对应动作在时序上不交叠,例如同一组试剂针中两两试剂针的吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作中,至少一个对应动作在时序上不交叠;这至少一个对应动作包括吸试剂动作和/或试剂针清洗动作。在另外的一些实施例中,样本分析装置中所有执行试剂分注的试剂针(包括第一试剂针 和第二试剂针),处理器会控制每根试剂都依次进行多个预设动作以完成加试剂操作,并且两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。如第一试剂针包括第一试剂针a1、第一试剂针a2,第二试剂针包括第二试剂针b1和第二试剂针b2。处理器控制第一试剂针a1、第一试剂针a2、第二试剂针b1和第二试剂针b2各自完成多个预设动作时,至少一个对应的预设动作在时序上不交叠。通过处理器对样本分析装置中的所有试剂针进行时序安排,避免试剂针之间的动作相互干涉抢占资源,从而更加有效地利用共用资源,提升样本分析装置的样本测试效率。In some embodiments, the processor 90 is used to control each reagent needle in the same group to perform multiple preset actions in sequence, such as a reagent suction action, a reagent heating action in the reagent needle, a reagent discharge action, and a reagent needle cleaning action to complete Reagent adding operation, and at least one corresponding preset action among the multiple preset actions between two reagent needles in the same group does not overlap in time sequence. For example, the first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles, and at least one of the corresponding preset actions between the two first reagent needles does not overlap in time sequence. The second set of reagent needles in the reagent dispensing component 60 includes two second reagent needles, and at least one corresponding preset action between the two second reagent needles does not overlap in time sequence. In some embodiments, the ping-pong mode may be set for the sample analysis device. When this mode is enabled, the processor 90 executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles is in time sequence. No overlap, for example, in the same group of reagent needles, at least one corresponding action does not overlap in time sequence of the reagent sucking action, the reagent heating action in the reagent needle, the reagent discharging action, and the reagent needle cleaning action. The corresponding actions include a reagent sucking action and/or a reagent needle cleaning action. In some other embodiments, for all reagent needles (including the first reagent needle and the second reagent needle) that perform reagent dispensing in the sample analysis device, the processor will control each reagent to perform multiple preset actions in sequence to complete Reagent adding operation, and at least one corresponding preset action among the plurality of preset actions between two reagent needles does not overlap in time sequence. For example, the first reagent needle includes a first reagent needle a1 and a first reagent needle a2, and the second reagent needle includes a second reagent needle b1 and a second reagent needle b2. When the processor controls the first reagent needle a1, the first reagent needle a2, the second reagent needle b1, and the second reagent needle b2 to each complete multiple preset actions, at least one corresponding preset action does not overlap in time sequence. The processor arranges all the reagent needles in the sample analysis device in time sequence to prevent the actions of the reagent needles from interfering with each other to grab resources, thereby more effectively using shared resources and improving the sample testing efficiency of the sample analysis device.
一些实施例的实施例中,上述多个预设动作可以包括第一类预设动作和第二类预设动作。第一类预设动作为各试剂针需要和同一部件交互的动作,通常地,第一类预设动作可以是试剂针需要占用公共资源的一些动作,例如吸试剂动作——这需要占用试剂承载部件40这一共公部件,例如试剂针清洗动作——这需要占用为各清洗池81共同提供清洗液的管路;因此,第一类预设动作至少包括吸试剂动作和试剂针清洗动作。第二类预设动作为各试剂不需要和同一部件交互的动作,通常地,第二类预设动作可以是试剂针不需要占用公共资源的一些动作,例如试剂加热动作——各试剂针针都通过各自的加热部件对所吸取的试剂加热;因此,第二类预设动作至少包括试剂针中试剂加热动作。一些实施例中,同一组内两两试剂针之间相对应的第一类预设动作在时序上都不交叠,例如同一组内两两试剂针之间的吸试剂动作在时序上不交叠,试剂针清洗动作在时序上不交叠,例如图18就是一个例子。In some embodiments, the aforementioned multiple preset actions may include a first type of preset action and a second type of preset action. The first type of preset action is the action that each reagent needle needs to interact with the same component. Generally, the first type of preset action can be some actions that the reagent needle needs to occupy public resources, such as the action of sucking reagent-which needs to occupy the reagent load. The common part of the component 40, such as the reagent needle cleaning action, needs to occupy a pipeline for providing the cleaning liquid for each cleaning tank 81; therefore, the first type of preset actions include at least a reagent suction action and a reagent needle cleaning action. The second type of preset actions are actions in which each reagent does not need to interact with the same component. Generally, the second type of preset actions can be actions that do not require common resources for reagent needles, such as reagent heating actions-each reagent needle Each heating component heats the sucked reagent; therefore, the second type of preset action includes at least the heating action of the reagent in the reagent needle. In some embodiments, the first type of preset actions corresponding to the two reagent needles in the same group do not overlap in time sequence, for example, the reagent sucking action between two reagent needles in the same group does not overlap in time sequence. The cleaning action of the reagent needle does not overlap in time sequence. For example, Figure 18 is an example.
一些实施例中,同一组内两两试剂针之间的所述多个预设动作中每个对应的预设动作在时序上都不交叠。例如图19就是一个例子。第一试剂分注部件60中第一组试剂针包括两根第一试剂针,这两根第一试剂针之间的吸试剂动作在时序上不交叠,试剂针中试剂加热动作在时序上不交叠,排试剂动作在时序上不交叠,试剂针清洗动作吸试剂动作在时序上也不交叠;再例如第二试剂分注部件60中第二组试剂针包括两根第二试剂针,这两根第二试剂针之间的吸试剂动作在时序上不交叠,试剂针中试剂加热动作在时序上不交叠,排试剂动作在时序上不交叠,试剂针清洗动作吸试剂动作在时序上也不交叠。In some embodiments, each corresponding preset action in the plurality of preset actions between two reagent needles in the same group does not overlap in time sequence. For example, Figure 19 is an example. The first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles. The reagent suction action between the two first reagent needles does not overlap in time sequence, and the reagent heating action in the reagent needle is in time sequence. No overlap, the sequence of the ejection of reagents does not overlap, and the sequence of the reagent needle cleaning action does not overlap the reagent sucking action; for another example, the second group of reagent needles in the second reagent dispensing part 60 includes two second reagents. Needle, the reagent suction action between the two second reagent needles does not overlap in time sequence, the reagent heating action in the reagent needle does not overlap in time sequence, the reagent ejection action does not overlap in time sequence, and the reagent needle cleaning action sucks The reagent actions do not overlap in timing.
一些实施例中,样本分析装置完成固定测试量时两个相邻且相同测试项目输出结果的时间间隔定义为一个周期,每个试剂分注部件的试剂针设置的数量与一个试剂针完成所述多个预设动作所占用的周期数量相等。例如一个试剂针完成上述多个预设动作(例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作)所占用的周期数量为二,那么就对试剂分注部件设置两根试剂针,或者说同一组内的试剂针数量为二。从另一个角度来说,一些实施例中,处理器90控制试剂分注部件的各试剂针在预设时间内完成所述多个预设动作(例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作),该预设时间等于N倍周期,N等于试剂分注部件的试剂针数量。例如每个试剂分注部件60的试剂针数量都为二,那么N就等于二,每个试剂针都需要在二个周期内完成所述多个预设动作(例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作)。通过这样设置试剂分注部件的试剂针数量以及其完成所述多个预设动作的周期,最终可以使得样本分析装置在测试速度上等效为每个试剂针都在一个周期内完成所述多个预设动作(例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作),确保样本分析装置输出检测结果的速度恒定。这里提及有预设时间,一些实施例中,试剂针执行多个预设的动作所花费的时间小于预设时间时,为了进一步确保样本分析装置输出检测结果的速度恒定,试剂针会进行等待,以使得等待的时间加上完成多个预设动作所花的时间相加等于预设时间。为了能够更加清楚地阐述,预设时间包括动作时间和等待时间,其中动作时间用于执行上述预设动作(例如吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作),动作时间小于或等于预设时间。在一些实施例中,等待时间被分割成一段或多段时间,并在时序上被插入到所述多个预设动作之间和/或最后一个预设动作之后——例如在时序上被插入到所述吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作之间和/或试剂针清洗动作之后;例如图20就是一个例子。一些实施例中,等待时间被分割成一段或多段时间,并在时序上至少有一段被作为额外的动作时间,用于执行预设动作。这样的话,可以使得预设动作有额外的时间来继续执行,在预设时间的约束下,预设动作的执行时间被延长了,这可以使 得试剂针有更稳定的表现,例如吸试剂动作和排试剂动作的执行时间被延长了,可以使得试剂针更稳定地吸取试剂和排试剂,不容易造成空吸或与反应杯碰撞等异外情况,再例如试剂针中试剂加热动作的执行时间被延长,可以使得试剂中试剂被加充分地预热;再例如,试剂针清洗动作的执行时间被延长了,可以使得试剂针被清洗得更加充分,不容易造成对下一个测试项目的交叉污染,提高了测试结果的准确性。因此,一些实施例中,样本分析装置可以包括充分加热模式,当该充分加热模式被启用时,处理器90执行该充分加热模式,以使得所述等待时间被分割成一段或多段时间,并在时序上至少有一段被作为额外的动作时间,用于执行试剂针中试剂加热动作。例如图21就是一个例子。In some embodiments, when the sample analysis device completes a fixed test volume, the time interval between two adjacent and identical test items outputting results is defined as a cycle, and the number of reagent needles set in each reagent dispensing component is equal to that of one reagent needle. The number of cycles occupied by multiple preset actions is equal. For example, the number of cycles occupied by one reagent needle to complete the above-mentioned multiple preset actions (for example, reagent suction action, reagent heating action in the reagent needle, reagent discharge action, and reagent needle cleaning action) is two, then two reagent dispensing components are set One reagent needle, or the number of reagent needles in the same group is two. From another perspective, in some embodiments, the processor 90 controls each reagent needle of the reagent dispensing component to complete the multiple preset actions within a preset time (for example, a reagent sucking action, a reagent heating action in the reagent needle, Reagent discharging action and reagent needle cleaning action), the preset time is equal to N times the period, and N is equal to the number of reagent needles of the reagent dispensing part. For example, if the number of reagent needles in each reagent dispensing part 60 is two, then N is equal to two. Each reagent needle needs to complete the multiple preset actions (for example, reagent sucking action, reagent needle Reagent heating action, reagent discharge action and reagent needle cleaning action). By setting the number of reagent needles of the reagent dispensing part and the cycle for completing the multiple preset actions in this way, the test speed of the sample analysis device can be equivalent to that each reagent needle completes the multiple in one cycle. Preset actions (such as sucking reagent, heating reagent in the reagent needle, discharging reagent, and cleaning reagent needle) ensure a constant output speed of the sample analysis device. There is a preset time mentioned here. In some embodiments, when the time it takes for the reagent needle to perform multiple preset actions is less than the preset time, in order to further ensure that the sample analysis device outputs the detection result at a constant speed, the reagent needle will wait , So that the waiting time plus the time spent to complete multiple preset actions add up to the preset time. In order to be able to explain more clearly, the preset time includes action time and waiting time, where the action time is used to perform the above-mentioned preset actions (for example, the action of sucking reagent, the action of heating the reagent in the reagent needle, the action of discharging the reagent, and the action of cleaning the reagent needle) The action time is less than or equal to the preset time. In some embodiments, the waiting time is divided into one or more periods of time, and is inserted between the plurality of preset actions and/or after the last preset action in time sequence—for example, it is inserted in time sequence Between the reagent suction action, the reagent heating action in the reagent needle, the reagent discharging action and the reagent needle cleaning action and/or after the reagent needle cleaning action; for example, FIG. 20 is an example. In some embodiments, the waiting time is divided into one or more periods, and at least one period in the sequence is used as an additional action time for performing a preset action. In this way, the preset action can have extra time to continue to execute. Under the constraint of the preset time, the execution time of the preset action is prolonged, which can make the reagent needle have more stable performance, such as the action of sucking reagent and The execution time of the reagent ejection action has been prolonged, which can make the reagent needle suck and eject the reagent more stably, and it is not easy to cause abnormal conditions such as empty suction or collision with the reaction cup. For example, the execution time of the reagent heating action in the reagent needle is reduced The extension can make the reagents in the reagents be fully preheated; for another example, the execution time of the reagent needle cleaning action is prolonged, which can make the reagent needles cleaned more fully, and it is not easy to cause cross-contamination of the next test item. Improve the accuracy of test results. Therefore, in some embodiments, the sample analysis device may include a full heating mode. When the full heating mode is activated, the processor 90 executes the full heating mode so that the waiting time is divided into one or more periods, and At least one period in the sequence is used as an additional action time for executing the reagent heating action in the reagent needle. For example, Figure 21 is an example.
需要说有的是,图18至图21中,为了便于作图,图中加热动作是指本文中试剂针中试剂加热动作,清洗动作是指本文中试剂针清洗动作;图18至图21中画出的两根试剂针是指同一组内的两根试剂针,例如第一组试剂针中的两根第一试剂针,或者第二组试剂针中的两根第二试剂针。What needs to be said is that in Figures 18-21, in order to facilitate the drawing, the heating action in the figure refers to the heating action of the reagent in the reagent needle in this article, and the cleaning action refers to the cleaning action of the reagent needle in this article; Figures 18 to 21 are drawn The two reagent needles refer to the two reagent needles in the same group, for example, the two first reagent needles in the first group of reagent needles, or the two second reagent needles in the second group of reagent needles.
本发明对试剂针的动作时序进行了设计,引入试剂分注部件具有例如两根平行排布的试剂针,独立直线运行的双试剂针通过乒乓调度,扩展周期完成吸试剂、预热、排试剂和清洗的整个工作流程,提供双倍资源,确保速度提升,从而实现多个检测项目测试不降速的目标。In the present invention, the action sequence of the reagent needle is designed. The introduced reagent dispensing component has, for example, two reagent needles arranged in parallel. The double reagent needles running independently and linearly are scheduled through ping-pong, and the extended cycle completes reagent suction, preheating, and reagent discharge. The entire workflow of cleaning and cleaning provides double resources to ensure speed increase, so as to achieve the goal of no slowdown in testing of multiple inspection items.
下面再对反应杯如何通过调度部件70进行调度进行说明。一些实施例中,本发明通过三个转运部件和两个缓存中转位来进行反应杯的转运。The following describes how the reaction cups are scheduled by the scheduling component 70. In some embodiments, the present invention uses three transfer components and two buffer transfers to transfer the cuvette.
本发明一些实施例中还公开了一种样本分析装置的方法,请参照图22,该方法可以包括以下步骤:Some embodiments of the present invention also disclose a method of a sample analysis device. Please refer to FIG. 22. The method may include the following steps:
步骤200,控制第一转运部件将加样完成的反应杯运送到第一缓存中转位。一些实施例中,步骤200控制第一转运部件沿第一方向直线运动,将加样完成的反应杯运送到第一缓存中转位。In step 200, the first transfer component is controlled to transport the reaction cup after sample addition to the first buffer for transposition. In some embodiments, step 200 controls the first transport component to move linearly in the first direction, and transport the reaction cup after sample addition to the first buffer for indexing.
步骤210,控制第二转运部件将第一缓存中转位的反应杯运送到孵育位。这里的孵育位可以是反应部件51中的反应杯放置位。一些实施例中,步骤210控制所述第二转运部件通过沿第一方向的直线运动和第二方向的直线运动,将第一缓存中转位的反应杯运送到孵育位。Step 210: Control the second transport component to transport the transposed cuvette in the first buffer to the incubation position. The incubation position here may be a reaction cup placement position in the reaction component 51. In some embodiments, step 210 controls the second transport member to transport the transposed cuvette in the first buffer to the incubation position through linear movement in the first direction and linear movement in the second direction.
步骤220,控制第二转运部件将孵育位中试样孵育完成的反应杯运送到第二缓存中转位。In step 220, the second transport component is controlled to transport the reaction cup that has completed the sample incubation in the incubation position to the second buffer for transposition.
一些实施例中,步骤220控制第二转运部件通过沿第一方向的直线运动和第二方向的直线运动,将孵育位中试样孵育完成的反应杯运送到第二缓存中转位。具体的一些实施例中,步骤220控制第二转运部件先将第一缓存中转位的反应杯运送到用于加试剂的孵育中转位,再将在孵育中转位加完试剂的反应杯运送到孵育位。In some embodiments, step 220 controls the second transport component to transport the reaction cups completed with the sample in the incubation position to the second buffer for transposition through linear motion in the first direction and linear motion in the second direction. In some specific embodiments, step 220 controls the second transport component to first transport the cuvettes transposed in the first buffer to the incubation for adding reagents, and then transport the cuvettes translocated and added reagents during the incubation to the incubation. Bit.
一些具体的实施例中,步骤220在将反应杯从孵育中转位运送到孵育位的过程中,控制第二转运部件对反应杯中的试样进行混匀。在第二转运部件转运反应杯时,还控制第二转运部件对反应杯中的试样进行混匀,节省了时间,不用特意先将反应杯调度到相应的混匀机构进行混匀。In some specific embodiments, in step 220, during the transposition and transportation of the reaction cup from the incubation to the incubation position, the second transfer component is controlled to mix the sample in the reaction cup. When the second transfer component transfers the reaction cup, the second transfer component is also controlled to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
步骤230,控制第三转运部件将第二缓存中转位的反应杯运送到测定位。Step 230: Control the third transport component to transport the indexed cuvette in the second buffer to the measurement position.
一些实施例中,步骤230控制第三转运部件通过沿第一方向的直线运动和第二方向的直线运动,将第二缓存中转位的反应杯运送到测定位。具体的一些实施例中,步骤230控制第二转运部件先将第二缓存中转位的反应杯运送到用于加试剂的测定中转位,再将在测定中转位加完试剂的反应杯运送到测定位。In some embodiments, step 230 controls the third transport component to transport the indexed cuvette in the second buffer to the measurement position through linear movement in the first direction and linear movement in the second direction. In some specific embodiments, step 230 controls the second transport component to first transport the cuvettes indexed in the second buffer to the assay for adding reagents, and then transport the cuvettes after the indexing and adding reagents during the assay to the assay. Bit.
一些具体的实施例中,步骤230在将反应杯从第二缓存中转位运送到测定位的过程中,控制所述第三转运部件对反应杯中的试样进行混匀。在第三转运部件转运反应杯时,还控制第三转运部件对反应杯中的试样进行混匀,节省了时间,不用特意先将反应杯调度到相应的混匀机构进行混匀。In some specific embodiments, step 230 controls the third transfer component to mix the sample in the reaction cup during the transposition and transportation of the reaction cup from the second buffer to the measurement position. When the third transfer component transfers the reaction cup, it also controls the third transfer component to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.
通过三个转运部件沿直线运动来实现反应杯的快速转运,配合两个缓存中转位,反应杯的调度路径简单和直接,有利于样本分析装置的提速。The three transport components move along a straight line to realize the rapid transport of the reaction cup. With two buffers, the scheduling path of the reaction cup is simple and direct, which is beneficial to the speed-up of the sample analysis device.
最后不妨以样本分析装置包括具有两根第一试剂针61的第一试剂分注部件60、具有两根第二试剂针61的第二试剂分注部件60、反应部件51和测定部件52为例,结合一个具体的测试项目来说明本发明。Finally, take the sample analysis device including a first reagent dispensing part 60 having two first reagent needles 61, a second reagent dispensing part 60 having two second reagent needles 61, a reaction part 51, and a measurement part 52 as an example. ,Combine a specific test item to illustrate the present invention.
反应部件51具有一定数量的反应杯放置位,,并可以对位于反应杯放置位上的反应杯内试样进行加热,以对试样进行孵育。根据测试项目的不同,一些测试项目会需要添加第一试剂,例如混合试剂。例如,就基于凝固法的测定项目APTT 进行测试时,第一试剂分注部件60从试剂承载部件40中吸取第一试剂,例如混合试剂,并将所吸取的第一试剂排入位于反应部件51的孵育中转位51a的反应杯,从而完成第一试剂和样本的混合。完成混合试剂的添加后,第二转运部件73可以对反应杯内的反应液进行混匀,然后将反应杯放置到反应部件51中,反应部件51对反应杯的反应液或者说试样进行孵育。The reaction component 51 has a certain number of reaction cup placement positions, and can heat the sample in the reaction cup located on the reaction cup placement position to incubate the sample. According to different test items, some test items may need to add a first reagent, such as a mixed reagent. For example, when testing the measurement item APTT based on the coagulation method, the first reagent dispensing part 60 sucks the first reagent, for example, mixed reagents, from the reagent carrying part 40, and discharges the sucked first reagent into the reaction part 51 In the incubation, the reaction cup of 51a is transposed to complete the mixing of the first reagent and the sample. After completing the addition of the mixed reagents, the second transfer part 73 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the reaction part 51, and the reaction part 51 incubates the reaction solution or sample in the reaction cup .
试剂承载部件40为保证试剂的活性,因此通常工作温度较低,例如通常在16℃以下。为保证凝血反应过程充分,得到准确的测试结果,第一试剂需要在加入反应杯中与样本混合前,被加热到37℃左右。为提高样本分析装置的测试速度,需要在较短时间内完成对第一试剂的加热,因此第一试剂分注部件60的两个第一试剂针61都有加热部件,用于完成试剂加热功能。通常情况下,对试剂的加热时间需要4~10秒,对于高速的样本分析装置,单工作周期例如为8秒,这样的话,对试剂的加热时间就会占用较久,这对于提升样本分析装置的测试速度影响很大。因此,本发明一些实施例中,第一试剂分注部件60具有两根第一试剂针61,两个第一试剂针61分别从试剂承载部件40中吸取第一试剂例如混合试剂,通过固定在直线横梁上的直线导轨移动到孵育中转位51a,并轮流向反应杯中添加第一试剂例如混合试剂。这两根第一试剂针61平行排布,独立运动。由于具有两个独立的第一试剂针61,因此第一试剂分注部件60的工作周期时间加倍,可以扩展到16秒,可以充分保证试剂针的加热部件对第一试剂有充分的加热时间,使得试剂温度稳定达到37℃。The reagent carrying member 40 is to ensure the activity of the reagent, so the working temperature is usually low, for example, usually below 16°C. In order to ensure that the coagulation reaction process is sufficient and obtain accurate test results, the first reagent needs to be heated to about 37°C before being added to the reaction cup and mixed with the sample. In order to increase the test speed of the sample analysis device, it is necessary to complete the heating of the first reagent in a relatively short time. Therefore, the two first reagent needles 61 of the first reagent dispensing part 60 have heating parts for completing the reagent heating function . Normally, the heating time for the reagents requires 4-10 seconds. For high-speed sample analysis devices, the single working cycle is, for example, 8 seconds. In this case, the heating time for the reagents will take a long time, which is important for upgrading the sample analysis device. The test speed has a great impact. Therefore, in some embodiments of the present invention, the first reagent dispensing part 60 has two first reagent needles 61, and the two first reagent needles 61 respectively suck the first reagent, such as mixed reagent, from the reagent carrying part 40, and are fixed in The linear guide on the linear beam moves to the incubation position 51a, and the first reagent, such as mixed reagent, is added to the reaction cup in turn. The two first reagent needles 61 are arranged in parallel and move independently. Since there are two independent first reagent needles 61, the working cycle time of the first reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the first reagent. Make the reagent temperature stably reach 37°C.
反应杯中的试样在反应部件51中加热孵育固定时间后,通过第二转运部件73和第三转运部件75的配合,将反应杯向测定部件52转运,一些实施例中,途中可以经过测定中转位52a,用于加入第二试剂例如触发试剂。After the sample in the reaction cup is heated and incubated in the reaction part 51 for a fixed period of time, the reaction cup is transferred to the measurement part 52 through the cooperation of the second transfer part 73 and the third transfer part 75. In some embodiments, the measurement can be carried out on the way. The intermediate position 52a is used to add a second reagent such as a trigger reagent.
第三转运部件75将反应杯转运到测定中转位52a,第二试剂分注部件60从试剂承载部件40中吸取第二试剂例如触发试剂,移动到第三转运部件75所抓取的反应杯的上方,向反应杯中添加第二试剂例如触发试剂,这样完成第二试剂与样本的混合。完成触发试剂的添加后,第三转运部件75可以对反应杯内的反应液进行混匀,然后将反应杯放置到测定部件52中,进行凝血信号分析检测,得到检测结果。The third transfer part 75 transfers the cuvette to the measuring transposition 52a, and the second reagent dispensing part 60 sucks the second reagent, such as the trigger reagent, from the reagent carrying part 40, and moves it to the cuvette gripped by the third transfer part 75. Above, a second reagent such as a trigger reagent is added to the reaction cup to complete the mixing of the second reagent and the sample. After completing the addition of the trigger reagent, the third transfer component 75 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the measurement component 52 to perform coagulation signal analysis and detection to obtain the detection result.
与第一试剂分注部件60类似,为保证第二试剂例如触发试剂有充分的加热时间,第二试剂分注部件60同样具有两根试剂针,例如两根第二试剂针;这两根第二试剂针分别从试剂承载部件40中吸取第二试剂例如触发试剂,通过固定在直线横梁上的直线导轨移动到测定中转位52a,轮流向反应杯中添加第二试剂例如触发试剂。这两根第二试剂针61平行排布,独立运动。由于具有两个独立的第二试剂针61,因此第二试剂分注部件60的工作周期时间加倍,可以扩展到16秒,可以充分保证试剂针的加热部件对第二试剂有充分的加热时间,使得试剂温度稳定达到37℃。Similar to the first reagent dispensing part 60, in order to ensure sufficient heating time for the second reagent, such as the trigger reagent, the second reagent dispensing part 60 also has two reagent needles, such as two second reagent needles; The two reagent needles respectively suck the second reagent, such as trigger reagent, from the reagent carrying member 40, move to the measuring index 52a through the linear guide rail fixed on the linear beam, and add the second reagent, such as trigger reagent, to the reaction cup in turn. The two second reagent needles 61 are arranged in parallel and move independently. Since there are two independent second reagent needles 61, the working cycle time of the second reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the second reagent. Make the reagent temperature stably reach 37°C.
在测定部件52中的反应杯经过多波长光照射,用测定部件52中例如光检测器接收其透射光或者散射光,并输出与受光光量相对应的检测信号,检测信号可以被送到例如处理器90用于数据的分析、处理和生成相应的显示内容。样本分析装置例如全自动凝血分析仪中可以采用凝固法、免疫比浊法和发色底物法等不同的方法进行样本分析,根据检测方法的不同,测定部件52中向反应杯照射不同波长的光,波长范围例如可以是405nm到800nm之间。The reaction cup in the measuring part 52 is irradiated with multi-wavelength light, and the transmitted light or scattered light is received by, for example, a photodetector in the measuring part 52, and a detection signal corresponding to the amount of received light is output. The detection signal can be sent to, for example, processing The device 90 is used for data analysis, processing and generation of corresponding display content. Sample analysis devices such as automatic coagulation analyzers can use different methods such as coagulation method, immunoturbidimetric method, and chromogenic substrate method for sample analysis. Depending on the detection method, the measuring part 52 irradiates the reaction cup with different wavelengths. For light, the wavelength range can be, for example, between 405 nm and 800 nm.
完成测试的反应杯可以由第三转运部件75移送至废弃回收装置中——废弃回收装置可以具有例如本文提及的第二抛杯位,第三转运部件75将反应杯丢弃到第二抛杯位内,完成反应杯的废弃处理。The reaction cup that has completed the test can be transferred to the waste recycling device by the third transfer component 75-the waste recycling device can have, for example, the second throwing cup position mentioned herein, and the third transfer component 75 discards the reaction cup to the second throwing cup In the position, the disposal of the reaction cup is completed.
本文参照了各种示范实施例进行说明。然而,本领域的技术人员将认识到,在不脱离本文范围的情况下,可以对示范性实施例做出改变和修正。例如,各种操作步骤以及用于执行操作步骤的组件,可以根据特定的应用或考虑与系统的操作相关联的任何数量的成本函数以不同的方式实现(例如一个或多个步骤可以被删除、修改或结合到其他步骤中)。This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope of this document. For example, various operation steps and components used to perform the operation steps can be implemented in different ways according to a specific application or considering any number of cost functions associated with the operation of the system (for example, one or more steps can be deleted, Modify or incorporate into other steps).
在上述实施例中,可以全部或部分地通过软件、硬件、固件或者其任意组合来实现。另外,如本领域技术人员所理解的,本文的原理可以反映在计算机可读存储介质上的计算机程序产品中,该可读存储介质预装有计算机可读程序代码。任何有形的、非暂时性的计算机可读存储介质皆可被使用,包括磁存储设备(硬盘、软盘等)、光学存储设备(CD至ROM、DVD、Blu Ray盘等)、闪存和/或诸如此类。这些计算机程序指令可被加载到通用计算机、专用计算机或其 他可编程数据处理设备上以形成机器,使得这些在计算机上或其他可编程数据处理装置上执行的指令可以生成实现指定的功能的装置。这些计算机程序指令也可以存储在计算机可读存储器中,该计算机可读存储器可以指示计算机或其他可编程数据处理设备以特定的方式运行,这样存储在计算机可读存储器中的指令就可以形成一件制造品,包括实现指定功能的实现装置。计算机程序指令也可以加载到计算机或其他可编程数据处理设备上,从而在计算机或其他可编程设备上执行一系列操作步骤以产生一个计算机实现的进程,使得在计算机或其他可编程设备上执行的指令可以提供用于实现指定功能的步骤。In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. In addition, as understood by those skilled in the art, the principles herein can be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with computer-readable program code. Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD to ROM, DVD, Blu Ray disks, etc.), flash memory and/or the like . These computer program instructions can be loaded on a general-purpose computer, a special-purpose computer or other programmable data processing equipment to form a machine, so that these instructions executed on the computer or other programmable data processing equipment can generate a device that realizes the specified functions. These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing equipment to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a piece of Manufactured products, including realizing devices that realize designated functions. Computer program instructions can also be loaded on a computer or other programmable data processing equipment, so as to execute a series of operation steps on the computer or other programmable equipment to produce a computer-implemented process, so that the execution on the computer or other programmable equipment Instructions can provide steps for implementing specified functions.
虽然在各种实施例中已经示出了本文的原理,但是许多特别适用于特定环境和操作要求的结构、布置、比例、元件、材料和部件的修改可以在不脱离本披露的原则和范围内使用。以上修改和其他改变或修正将被包含在本文的范围之内。Although the principles herein have been shown in various embodiments, many modifications to the structure, arrangement, proportions, elements, materials, and components that are particularly suitable for specific environments and operating requirements can be made without departing from the principles and scope of this disclosure. use. The above modifications and other changes or amendments will be included in the scope of this article.
前述具体说明已参照各种实施例进行了描述。然而,本领域技术人员将认识到,可以在不脱离本披露的范围的情况下进行各种修正和改变。因此,对于本披露的考虑将是说明性的而非限制性的意义上的,并且所有这些修改都将被包含在其范围内。同样,有关于各种实施例的优点、其他优点和问题的解决方案已如上所述。然而,益处、优点、问题的解决方案以及任何能产生这些的要素,或使其变得更明确的解决方案都不应被解释为关键的、必需的或必要的。本文中所用的术语“包括”和其任何其他变体,皆属于非排他性包含,这样包括要素列表的过程、方法、文章或设备不仅包括这些要素,还包括未明确列出的或不属于该过程、方法、系统、文章或设备的其他要素。此外,本文中所使用的术语“耦合”和其任何其他变体都是指物理连接、电连接、磁连接、光连接、通信连接、功能连接和/或任何其他连接。The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of this disclosure. Therefore, the consideration of this disclosure will be in an illustrative rather than restrictive sense, and all these modifications will be included in its scope. Likewise, the advantages, other advantages, and solutions to problems of the various embodiments have been described above. However, benefits, advantages, solutions to problems, and any elements that can produce these, or make them more specific, should not be construed as critical, necessary, or necessary. The term "including" and any other variants used in this article are non-exclusive inclusions. Such a process, method, article or device that includes a list of elements not only includes these elements, but also includes those that are not explicitly listed or are not part of the process. , Methods, systems, articles or other elements of equipment. In addition, the term "coupled" and any other variations thereof used herein refer to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection and/or any other connection.
具有本领域技术的人将认识到,在不脱离本发明的基本原理的情况下,可以对上述实施例的细节进行许多改变。因此,本发明的范围应仅由权利要求确定。Those skilled in the art will recognize that many changes can be made to the details of the above-described embodiments without departing from the basic principles of the present invention. Therefore, the scope of the present invention should only be determined by the claims.

Claims (21)

  1. 一种样本分析装置,其特征在于,包括:A sample analysis device, characterized in that it comprises:
    反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
    调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
    进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
    样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
    试剂承载部件,所述试剂承载部件呈圆盘状结构设置,并具有多个用于承载试剂容器的位置,所述试剂承载部件能够转动并带动其承载的试剂容器转动,用于将试剂容器转动到吸试剂位;A reagent carrying component, the reagent carrying component is arranged in a disc-shaped structure and has a plurality of positions for carrying reagent containers, the reagent carrying component can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container To the suction position;
    一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;其中各处理单元都配置有相应的加试剂中转位;以及One or more processing units; the processing unit is used to receive the cuvette carrying the sample dispatched by the scheduling component, and process the sample in the cuvette; wherein each processing unit is equipped with a corresponding reagent addition relay Bit; and
    试剂分注部件,具有试剂针;所述试剂针用于从吸试剂位吸取试剂并排放到位于加试剂中转位的反应杯中;其中每处加试剂中转位都被配置有一组所述试剂针,每组试剂针至少包括两根试剂针,所述试剂针被以在所述吸试剂位和对应的加试剂中转位之间独立地沿直线运动的方式所设置;The reagent dispensing component has a reagent needle; the reagent needle is used to suck reagent from the reagent suction position and discharge it into the reaction cup positioned in the reagent adding; wherein each position in the reagent adding is configured with a set of the reagent needles Each group of reagent needles includes at least two reagent needles, and the reagent needles are arranged in a manner of independently moving in a straight line between the reagent suction position and the corresponding reagent adding position;
    多个清洗池,分别设置于各试剂针的直线运动的轨迹上,用于对试剂针进行清洗;以及A plurality of washing tanks are respectively arranged on the track of the linear movement of each reagent needle for cleaning the reagent needle; and
    处理器;所述处理器用于控制每根试剂针都依次进行吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作以完成加试剂操作;所述样本分析装置包括乒乓模式,所述处理器执行所述乒乓模式,以使得每组试剂针中的两两试剂针之间的至少一个对应动作在时序上不交叠。The processor; the processor is used to control each reagent needle to sequentially perform a reagent suction action, a reagent heating action in the reagent needle, a reagent ejection action, and a reagent needle cleaning action to complete the reagent addition operation; the sample analysis device includes a ping-pong mode, The processor executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles does not overlap in time sequence.
  2. 如权利要求1所述的样本分析装置,其特征在于,所述至少一个对应动作包括吸试剂动作和/或试剂针清洗动作。The sample analysis device according to claim 1, wherein the at least one corresponding action comprises a reagent sucking action and/or a reagent needle cleaning action.
  3. 如权利要求1或2所述的样本分析装置,其特征在于,样本分析装 置完成固定测试量时两个相邻且相同测试项目输出结果的时间间隔定义为一个周期,所述试剂分注部件的试剂针设置的数量与一个试剂针完成吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作所占用的周期数量相等。The sample analysis device of claim 1 or 2, wherein when the sample analysis device completes a fixed test volume, the time interval between the output results of two adjacent and the same test items is defined as a cycle, and the time interval of the reagent dispensing component The set number of reagent needles is equal to the number of cycles occupied by a reagent needle to complete the action of sucking reagent, heating the reagent in the reagent needle, discharging the reagent, and cleaning the reagent needle.
  4. 如权利要求3所述的样本分析装置,其特征在于,所述处理器控制所述试剂分注部件的各试剂针在预设时间内依次完成吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作,所述预设时间等于N倍周期,N等于所述试剂分注部件的试剂针数量。The sample analysis device according to claim 3, wherein the processor controls the reagent needles of the reagent dispensing part to sequentially complete the reagent suction action, the reagent heating action in the reagent needle, and the reagent discharge action within a preset time. For action and reagent needle cleaning action, the preset time is equal to N times the period, and N is equal to the number of reagent needles of the reagent dispensing component.
  5. 如权利要求4所述的样本分析装置,其特征在于,所述试剂分注部件设置两根试剂针,所述处理器控制两所述试剂针在2个周期内完成吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作。The sample analysis device according to claim 4, wherein the reagent dispensing part is provided with two reagent needles, and the processor controls the two reagent needles to complete the reagent suction action within 2 cycles, and the reagent needle Reagent heating action, reagent discharge action and reagent needle cleaning action.
  6. 如权利要求1至5中任一项所述的样本分析装置,其特征在于,所述预设时间包括动作时间和等待时间,其中所述动作时间用于执行所述吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作,所述动作时间小于或等于所述预设时间。The sample analysis device according to any one of claims 1 to 5, wherein the preset time includes an action time and a waiting time, wherein the action time is used to perform the reagent suction action and the reagent needle For the reagent heating action, the reagent discharging action, and the reagent needle cleaning action, the action time is less than or equal to the preset time.
  7. 如权利要求6所述的样本分析装置,其特征在于,所述等待时间被分割成一段或多段时间,并在时序上被插入到所述吸试剂动作、试剂针中试剂加热动作、排试剂动作及试剂针清洗动作之间和/或试剂针清洗动作之后。The sample analysis device according to claim 6, wherein the waiting time is divided into one or more time periods, and is inserted into the reagent suction action, the reagent heating action in the reagent needle, and the reagent discharge action in time sequence. And between and/or after the reagent needle cleaning action.
  8. 如权利要求1至7中任一项所述的样本分析装置,其特征在于,还包括充分加热模式;所述处理器执行所述充分加热模式,以使得所述等待时间被分割成一段或多段时间,并在时序上至少有一段被作为额外的动作时间,用于执行所述试剂针中试剂加热动作。The sample analysis device according to any one of claims 1 to 7, further comprising a sufficient heating mode; the processor executes the sufficient heating mode so that the waiting time is divided into one or more segments Time, and at least one period in the sequence is used as an additional action time for performing the heating action of the reagent in the reagent needle.
  9. 一种样本分析装置,其特征在于,包括:A sample analysis device, characterized in that it comprises:
    反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
    调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
    进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
    样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
    试剂承载部件,具有多个用于承载试剂容器的位置;The reagent carrying component has a plurality of positions for carrying reagent containers;
    一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;One or more processing units; the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
    试剂分注部件,具有试剂针;各试剂针以能够互相独立运动的方式所设置;其中每一所述处理单元都被配置有一组所述试剂针;The reagent dispensing component has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a group of the reagent needles;
    所述试剂针用于从试剂承载部件吸取试剂并排放到相应的处理单元的反应杯中,且每组试剂针至少包括两根试剂针;The reagent needles are used to suck reagents from the reagent carrying part and discharge them into the reaction cups of the corresponding processing units, and each group of reagent needles includes at least two reagent needles;
    清洗部件,用于清洗试剂针;Cleaning parts, used to clean reagent needles;
    以及as well as
    处理器;所述处理器用于控制同一组内每根试剂针都依次进行多个预设动作以完成加试剂操作,并且同一组内两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。Processor; the processor is used to control each reagent needle in the same group to sequentially perform multiple preset actions to complete the reagent adding operation, and at least among the multiple preset actions between two reagent needles in the same group There is a corresponding preset action that does not overlap in timing.
  10. 如权利要求9所述的样本分析装置,其特征在于,所述多个预设动作包括第一类预设动作和第二类预设动作;同一组内两两试剂针之间相对应的第一类预设动作在时序上都不交叠;其中所述第一类预设动作为各试剂针需要和同一部件交互的动作,所述第二类预设动作为各试剂不需要和同一部件交互的动作。The sample analysis device according to claim 9, wherein the plurality of preset actions include a first type of preset action and a second type of preset action; the first corresponding between the two reagent needles in the same group The first type of preset action does not overlap in time sequence; wherein the first type of preset action is an action where each reagent needle needs to interact with the same component, and the second type of preset action is that each reagent does not need to interact with the same component Interactive action.
  11. 如权利要求10所述的样本分析装置,其特征在于,所述第一类预设动作至少包括吸试剂动作和试剂针清洗动作;所述第二类预设动作至少包括试剂针中试剂加热动作。The sample analysis device according to claim 10, wherein the first type of preset action includes at least a reagent sucking action and a reagent needle cleaning action; the second type of preset action at least includes a reagent heating action in the reagent needle .
  12. 如权利要求9至11中任一项所述的样本分析装置,其特征在于,同一组内两两试剂针之间的所述多个预设动作中每个对应的预设动作在时序上都不交叠。The sample analysis device according to any one of claims 9 to 11, wherein each of the plurality of preset actions between two reagent needles in the same group has a corresponding preset action in time sequence. Do not overlap.
  13. 如权利要求9至12中任一项所述的样本分析装置,其特征在于,样本分析装置完成固定测试量时两个相邻且相同测试项目输出结果 的时间间隔定义为一个周期,所述试剂分注部件的试剂针设置的数量与一个试剂针完成所述多个预设动作所占用的周期数量相等。The sample analysis device according to any one of claims 9 to 12, wherein when the sample analysis device completes a fixed test volume, the time interval between the output results of two adjacent and identical test items is defined as a cycle, and the reagent The set number of reagent needles of the dispensing component is equal to the number of cycles occupied by one reagent needle to complete the multiple preset actions.
  14. 如权利要求13所述的样本分析装置,其特征在于,所述处理器控制所述试剂分注部件的各试剂针在预设时间内完成所述多个预设动作,所述预设时间等于N倍周期,N等于所述试剂分注部件的试剂针数量。The sample analysis device according to claim 13, wherein the processor controls each reagent needle of the reagent dispensing part to complete the multiple preset actions within a preset time, and the preset time is equal to N times the period, N is equal to the number of reagent needles of the reagent dispensing part.
  15. 如权利要求13或14所述的样本分析装置,其特征在于,所述试剂分注部件设置两根试剂针,所述处理器控制两所述试剂针在2个周期内完成所述多个预设动作。The sample analysis device according to claim 13 or 14, wherein the reagent dispensing part is provided with two reagent needles, and the processor controls the two reagent needles to complete the multiple pre-treatments within 2 cycles. Set up the action.
  16. 如权利要求14或15所述的样本分析装置,其特征在于,所述预设时间包括动作时间和等待时间,其中所述动作时间用于执行所述预设动作,所述动作时间小于或等于所述预设时间。The sample analysis device according to claim 14 or 15, wherein the preset time includes an action time and a waiting time, wherein the action time is used to execute the preset action, and the action time is less than or equal to The preset time.
  17. 如权利要求16所述的样本分析装置,其特征在于,所述等待时间被分割成一段或多段时间,并在时序上被插入到所述多个预设动作之间和/或最后一个预设动作之后。The sample analysis device according to claim 16, wherein the waiting time is divided into one or more periods, and is inserted between the plurality of preset actions and/or the last preset in time sequence. After the action.
  18. 如权利要求16所述的样本分析装置,其特征在于,所述等待时间被分割成一段或多段时间,并在时序上至少有一段被作为额外的动作时间,用于执行预设动作。The sample analysis device of claim 16, wherein the waiting time is divided into one or more periods, and at least one period in the time sequence is used as an additional action time for performing a preset action.
  19. 如权利要求18所述的样本分析装置,其特征在于,所述额外的动作时间用于执行试剂针中试剂加热动作。The sample analysis device of claim 18, wherein the additional action time is used to perform a heating action of the reagent in the reagent needle.
  20. 如权利要求9至19中任一项所述的样本分析装置,其特征在于,试剂承载部件具有吸试剂位,每一所述处理单元配置有相应的加试剂中转位;所述试剂针被以在所述吸试剂位和对应的加试剂中转位之间沿直线运动的方式所设置,且至少两所述试剂针在竖直方向上运动,以从所述试剂容器中吸取试剂并将吸取的试剂排放反应杯中。The sample analysis device according to any one of claims 9 to 19, wherein the reagent carrying member has a reagent suction position, and each of the processing units is equipped with a corresponding reagent adding and transposition; the reagent needle is It is set in a linear movement between the reagent suction position and the corresponding reagent adding position, and at least two reagent needles move in the vertical direction to suck reagent from the reagent container and The reagent is discharged into the reaction cup.
  21. 一种样本分析装置,其特征在于,包括:A sample analysis device, characterized in that it comprises:
    反应杯装载部件,用于供应并运载空反应杯;The reaction cup loading parts are used to supply and carry empty reaction cups;
    调度部件,用于调度反应杯;Scheduling component for scheduling reaction cups;
    进样部件,用于将待进样的样本调度到吸样位;Sampling component, used to schedule the sample to be injected to the sample suction position;
    样本分注部件,用于从吸样位吸取样本并排放到位于加样位的反应杯中;The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;
    试剂承载部件,具有多个用于承载试剂容器的位置;The reagent carrying component has a plurality of positions for carrying reagent containers;
    一个或多个处理单元;所述处理单元用于接收由调度部件调度过来的承载有试样的反应杯,并对反应杯的试样进行处理;One or more processing units; the processing unit is used to receive the reaction cups carrying samples dispatched by the scheduling component, and process the samples of the reaction cups;
    试剂分注部件,具有试剂针;各试剂针以能够互相独立运动的方式所设置;其中每一所述处理单元都被配置有一组所述试剂针;The reagent dispensing component has a reagent needle; each reagent needle is arranged in a manner capable of moving independently of each other; wherein each of the processing units is configured with a group of the reagent needles;
    所述试剂针用于从试剂承载部件吸取试剂并排放到相应的处理单元的反应杯中,且每组试剂针至少包括两根试剂针;The reagent needles are used to suck reagents from the reagent carrying part and discharge them into the reaction cups of the corresponding processing units, and each group of reagent needles includes at least two reagent needles;
    清洗部件,用于清洗试剂针;Cleaning parts, used to clean reagent needles;
    以及as well as
    处理器;所述处理器用于控制每根试剂都依次进行多个预设动作以完成加试剂操作,并且两两试剂针之间的所述多个预设动作中至少有一个对应的预设动作在时序上不交叠。Processor; the processor is used to control each reagent to sequentially perform multiple preset actions to complete the reagent adding operation, and at least one of the multiple preset actions between the two reagent needles has a corresponding preset action There is no overlap in timing.
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