CN109406799A - Sample analysis apparatus, reagent adding device, and control method thereof - Google Patents
Sample analysis apparatus, reagent adding device, and control method thereof Download PDFInfo
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- CN109406799A CN109406799A CN201710703970.1A CN201710703970A CN109406799A CN 109406799 A CN109406799 A CN 109406799A CN 201710703970 A CN201710703970 A CN 201710703970A CN 109406799 A CN109406799 A CN 109406799A
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- reagent
- needle
- cleaning
- reagent needle
- adding device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
Abstract
The invention provides a reagent adding device, which comprises: the driving mechanism is used for outputting rotary motion and reciprocating lifting motion; the fixing frame is connected to the driving mechanism, the driving mechanism drives the fixing frame to do reciprocating lifting motion and rotating motion, and the fixing frame comprises a first fixing end and a second fixing end; the reagent needle mechanism comprises a first reagent needle and a second reagent needle, the first reagent needle is arranged on the first fixing end, and the second reagent needle is arranged on the second fixing end; a heating mechanism for heating at least one of the first and second reagent needles; the supporting frame is connected with and supports the fixing frame; the utilization rate of the driving mechanism is improved, and the efficiency of the sample analysis equipment is improved. The invention also provides a sample analysis device and a control method of the reagent adding device.
Description
Technical field
The present invention relates to technical field of medical equipment, more particularly to a kind of sample analysis apparatus, reagent adding device and its
Control method.
Background technique
Automatic coagulation analyzer is the instrument for carrying out blood coagulation and anticoagulant, fibrinolytic and the analysis of anti-fibrinolytic function to blood
Device.Automatic coagulation analyzer generally comprises: sample storage device, test device, sample adding device, grabs cup at reagent refrigerating device
Device and automatically into cup device.Its workflow is substantially as follows: being automatically transported to test cup into cup device and grabs cup position, grabs cup
In setting grab glass hand by blood clotting test cup from the sample needle in the test position grabbed cup position and be transported to test device, sample adding device by sample
The reaction reagent in blood sample and reagent refrigerating device in this storage device be transported to test position test cup in, sample and
Reagent reacts in test cup, and test device measures reaction result.
Currently, in the automatic detection field of medical instrument, be generally fitted provided with by reagent from reagent refrigerating device be transferred to
The reagent needle of test device test position.In general, reagent needle and its driving assembly carry out horizontal drive in the direction X/Y, moreover, reagent
Needle set has the Rotary rocker arm structure of its rotation of driving, to realize reagent needle transfering reagent.It is arranged in Rotary rocker arm structure
One reagent needle, the reagent needle need that the several seconds is waited to heat the reagent in reagent needle when executing heating operation, heating
Other could be executed after the completion and such as adds reagent operation, i.e., cannot execute other operations when reagent needle executes heating operation, drive
The equal candidate agents needle heating that can remain static of motivation structure finishes and goes driving reagent needle rotation again, will lead to the wasting of resources in this way,
So that driving assembly utilization rate is not high, and then influences the operating efficiency of automatic coagulation analyzer, full automatic blood-coagulation point cannot be made
Analyzer realizes more preferably function.
Summary of the invention
Based on this, it is necessary to for not high by driving assembly utilization rate caused by a reagent needle transfering reagent at present
Problem provides a kind of reagent adding device that can be improved utilization rate and then improve operating efficiency, while also providing one kind and being applied to
The control method of above-mentioned reagent adding device, and a kind of sample analysis apparatus containing above-mentioned reagent adding device is provided.
Above-mentioned purpose is achieved through the following technical solutions:
A kind of reagent adding device, comprising:
Driving mechanism, the driving structure is for exporting rotary motion and reciprocal elevating movement；
Fixed frame, is connected to the driving mechanism, the driving mechanism drive the fixed frame do reciprocal elevating movement and
Rotary motion, the fixed frame include the first fixing end and the second fixing end；
Reagent needle mechanism, including the first reagent needle and the second reagent needle, it is solid that the first reagent needle is set to described first
On fixed end, the second reagent needle is set in second fixing end；
Heating mechanism, for being heated at least one of the first reagent needle and the second reagent needle；And
Support frame connects and supports the fixed frame.
Line between first fixing end and the fixed frame center and described second in one of the embodiments,
30 °~180 ° of angular range of the line at fixing end and the fixed frame center.
Line between first fixing end and the fixed frame center and described second in one of the embodiments,
The angle of fixing end and the fixed frame line of centres is 180 °.
The heating mechanism includes the first heating element and the second heating element in one of the embodiments, and described the
One heating element is used to heat the reagent in the first reagent needle；Second heating element is used for second reagent
Reagent heating in needle.
The reagent adding device further includes control mechanism in one of the embodiments, and the control mechanism includes first
Temperature control mainboard and the second temperature control mainboard, the first temperature control mainboard and the second temperature control mainboard are respectively arranged at the fixed frame
On；
The first temperature control mainboard is electrically connected with first heating element, for controlling first heating element to examination
The heating temperature of agent；The second temperature control mainboard is electrically connected with second heating element, for controlling second heating part
Heating temperature of the part to reagent.
The control mechanism further includes the first detection mainboard in one of the embodiments, and second detects mainboard, described
First detection mainboard and the second detection mainboard are all set on the fixed frame；
The first detection mainboard is used to detect the liquid level in the reagent bottle of the first reagent needle absorption reagent；Institute
State the liquid level in reagent bottle of the second detection mainboard for detecting the second reagent needle absorption reagent.
The reagent adding device further includes wiper mechanism in one of the embodiments, and the wiper mechanism includes cleaning
Supervisor, the first cleaning branch pipe and the second cleaning branch pipe；
It is described first cleaning branch pipe one end be connected to the first reagent needle, it is described first clean branch pipe the other end and
The cleaning supervisor connection；One end of the second cleaning branch pipe is connected to the second reagent needle, the second cleaning branch pipe
The other end and the cleaning supervisor be connected to.
Main valve is cleaned in setting on the cleaning supervisor in one of the embodiments, is arranged on the first cleaning branch pipe
First cleaning branch valve, described second cleans the second cleaning of setting branch valve on branch pipe；Wherein,
The cleaning main valve and the first cleaning branch valve are opened, and the second cleaning branch valve is closed, to control described the
The cleaning of one reagent needle；
The first cleaning branch valve is opened, the cleaning main valve and the second cleaning branch valve closing, to control described the
One reagent needle is drawn or discharge reagent.
The cleaning main valve and the first cleaning branch valve are turned off in one of the embodiments, to control described the
The heating of reagent in one reagent needle.
The driving mechanism includes shaft, the first driving assembly and the second driving assembly, institute in one of the embodiments,
Fixed mount setting is stated in the shaft, first driving assembly is installed on second driving assembly, and described first drives
Dynamic component is connect with the shaft with second driving assembly, and first driving assembly is revolved for driving the shaft to do
Transhipment is dynamic, and second driving assembly is for driving the shaft to move up and down.
The control method for further relating to a kind of reagent adding device, includes the following steps:
The fixed frame of the reagent adding device drives the first reagent needle and the second reagent needle moves up and down and rotary motion,
The first reagent needle and the second reagent needle execute cleaning, draw reagent, heating reagent and discharge reagent operation；
When reagent in the first reagent needle is heated, the second reagent needle turns to corresponding position and executes clearly
It washes, draw reagent, heating one of reagent and discharge reagent or multiple combinations operation.
In one of the embodiments, when the second reagent needle executes multiple combinations operation, the second reagent needle
According to cleaning, the circulation execution that puts in order drawn reagent, heat reagent, discharge reagent.
When the reagent in the second reagent needle is heated in one of the embodiments, the first reagent needle turns
It moves to corresponding position sequence and executes one of discharge reagent, cleaning, absorption reagent and heating reagent or multiple combinations operation.
When the first reagent needle executes cleaning operation in one of the embodiments, the cleaning of the first reagent needle
Fluid path is connected, and after the completion of cleaning, the cleaning fluid path is disconnected；
When the first reagent needle executes absorption reagent operation, the compressing fluid path of the first reagent needle is connected, and draws examination
After the completion of agent, the compressing fluid path is disconnected；
When the first reagent needle executes discharge reagent operation, the compressing fluid path of the first reagent needle is connected, and spue examination
After the completion of agent, the compressing fluid path is disconnected.
Further relate to a kind of sample analysis apparatus, including sample incubation device, reagent storage means, sample testing apparatus and
Reagent adding device as described in any of the above-described technical characteristic；
The sample incubation device and the reagent storage means are arranged side by side, and the sample testing apparatus is set to described
The side of sample incubation device and the reagent storage means, the reagent adding device are set to the sample incubation device, institute
It states between reagent storage means and the sample testing apparatus three, the reagent adding device can be by the reagent storage means
In agent transfer to the sample incubation device or the sample testing apparatus on.
The first reagent needle of the reagent adding device is drawn in the reagent storage means in one of the embodiments,
When reagent, bit space is kept away for first in space locating for the second reagent needle；
The first reagent needle of the reagent adding device is in discharge reagent on the sample incubation device, and described second
Bit space is kept away for second in space locating for reagent needle；
The first reagent needle of the reagent adding device is in the sample testing apparatus discharge reagent, second examination
Space locating for agent needle is that third keeps away bit space；
For the first reagent needle of the reagent adding device in cleaning, space locating for the second reagent needle is the 4th
Keep away bit space.
The sample analysis apparatus further includes waterproof part in one of the embodiments, the sample testing apparatus packet
Paramagnetic particle method testing agency is included, the waterproof part covers between the paramagnetic particle method testing agency and the reagent storage means.
The invention has the benefit that
Sample analysis apparatus, reagent adding device and its control method of the invention, the first reagent needle and the second reagent needle point
It is not arranged in the first fixing end and the second fixing end of fixed frame, such driving mechanism is able to drive the first reagent needle and second
Reagent needle moves up and down, so that the first reagent needle and the second reagent needle turn to the station for drawing reagent or discharge reagent；It drives
Motivation structure drives the first reagent needle to move up and down with the second reagent needle, and the first reagent needle and the second reagent needle is enabled to carry out
Draw the operation of reagent or discharge reagent；Moreover, the first reagent needle, in absorption or discharge reagent, the second reagent needle can be to
It is stored to be heated in reagent wherein, in this way, the second reagent needle that heating is completed can shift reagent, meanwhile,
The the first reagent needle for not completing heating is being heated；Effective solution passes through at present drives caused by a reagent needle transfering reagent
The not high problem of dynamic component utilization rate, realizes the first reagent needle in absorption or discharge reagent, the second reagent is directed to examination therein
Agent is heated, and is improved the utilization rate of driving mechanism, and then improve the efficiency of agent transfer, is improved the effect of sample analysis apparatus
Rate, so that sample analysis apparatus plays more preferably effect.
Detailed description of the invention
Fig. 1 is the perspective view of the reagent adding device of one embodiment of the invention；
Fig. 2 is top view of the reagent adding device shown in FIG. 1 in sample analysis apparatus；
Fig. 3 is the fluid path figure of the first reagent needle and the second reagent needle in the reagent adding device of one embodiment of the invention；
Fig. 4 is the work flow diagram of the reagent adding device 100 of one embodiment of the invention；
Fig. 5 is the first reagent needle shown in Fig. 4 and the second reagent needle work flow diagram；
Fig. 6 is the work flow diagram of the first reagent needle work；
Wherein:
100- reagent adding device；
110- driving mechanism；
111- shaft；
The first driving assembly of 112-；The first driving motor of 1121-；The first transmission parts of 1122-；
The second driving assembly of 113-；The second driving motor of 1131-；The second transmission parts of 1132-；
120- fixed frame；
The first rocker arm of 121-；
The second rocker arm of 122-；
130- reagent needle mechanism；
131- the first reagent needle；
132- the second reagent needle；
140- support frame；
150- control mechanism；
151- the first temperature control mainboard；
152- the second temperature control mainboard；
153- first detects mainboard；
154- second detects mainboard；
160- wiper mechanism；
161- cleaning supervisor；
162- first cleans branch pipe；
163- second cleans branch pipe；
164- cleans main valve；
165- first cleans branch valve；
166- second cleans branch valve；
167- pump；
200- reagent storage means；
300- sample incubation device；
400- sample testing apparatus.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, by the following examples, it and combines attached
Figure, is further elaborated sample analysis apparatus of the invention, reagent adding device and its control method.It should be appreciated that
Described herein specific examples are only used to explain the present invention, is not intended to limit the present invention.
It is herein component institute serialization number itself, such as " first ", " second " etc., is only used for distinguishing described object,
Without any sequence or art-recognized meanings.And " connection ", " connection " described in the application, unless otherwise instructed, include directly and
It is indirectly connected with (connection).In the description of the present invention, it is to be understood that, term " on ", "lower", "front", "rear", " left side ",
The orientation of the instructions such as " right side ", "vertical", "horizontal", "top", "bottom", "inner", "outside", " clockwise ", " counterclockwise " or position are closed
System is merely for convenience of description of the present invention and simplification of the description to be based on the orientation or positional relationship shown in the drawings, rather than indicates
Or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot understand
For limitation of the present invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature in the second feature " on " or " down " can be with
It is that the first and second features directly contact or the first and second features pass through intermediary mediate contact.Moreover, fisrt feature exists
Second feature " on ", " top " and " above " but fisrt feature be directly above or diagonally above the second feature, or be merely representative of
First feature horizontal height is higher than second feature.Fisrt feature can be under the second feature " below ", " below " and " below "
One feature is directly under or diagonally below the second feature, or is merely representative of first feature horizontal height less than second feature.
Referring to Fig. 1 and Fig. 2, Fig. 1 is the perspective view of the reagent adding device 100 of one embodiment of the invention, and Fig. 2 is shown in Fig. 1
Top view of the reagent adding device 100 in sample analysis apparatus.The present invention provides a kind of reagent adding device 100, the additional examinations
Agent device 100 is applied in sample analysis apparatus, for reagent to be transferred to sample analysis apparatus from reagent storage means 200
Sample incubation device 300 in or be transferred in the sample testing apparatus 400 of sample analysis apparatus, after mixing sample with reagent
Sample is detected.After sample analysis apparatus uses reagent adding device 100 of the invention, driving mechanism 110 can be improved
Utilization rate, and then the efficiency of agent transfer is improved, the efficiency of sample analysis apparatus is improved, so that sample analysis apparatus plays more preferably
Effect.
In the present invention, reagent adding device 100 includes driving mechanism 110, fixed frame 120, reagent needle mechanism 130, heating
Mechanism (not shown) and support frame 140.Support frame 140 can play support fixed function, and driving mechanism 110 is set to support frame
On 140, driving is guaranteed so that driving mechanism 110 reliably fix by installation by the connection of support frame 140 and fixed drive mechanism 110
It is accurate, reliable that mechanism 110 moves.Driving mechanism 110 for exporting rotary motion and reciprocal elevating movement, driving mechanism 110 with
Fixed frame 120 connects, and reagent needle mechanism 130 is installed on fixed frame 120.Driving mechanism 110 is able to drive fixed frame 120 and does in this way
Elevating movement and rotary motion, so that the drive of fixed frame 120 reagent needle mechanism 130 moves up and down and rotary motion.Examination
Ji Zhen mechanism 130 be for transfering reagent, will be in agent transfer to sample incubation device 300 or sample testing apparatus 400.Gu
Determining frame 120 drives reagent needle mechanism 130 to move up and down, and reagent needle mechanism 130 is able to carry out the behaviour of absorption or discharge reagent
Make；When fixed frame 120 drives reagent needle mechanism 130 to make rotating motion, reagent needle mechanism 130 can rotate to corresponding position
On, reactant station, the first reagent adding station of sample incubation device 300 or pattern detection dress are inhaled such as reagent storage means 200
The the second reagent adding station for setting 400 facilitates reagent needle mechanism 130 to execute absorption or discharge reagent operation.
Specifically, fixed frame 120 includes the first fixing end and the second fixing end.Reagent needle mechanism 130 includes the first reagent
Needle 131 and the second reagent needle 132, the first reagent needle 131 are set in the first fixing end, and the second reagent needle 132 is set to second
In fixing end.Optionally, fixed frame 120 includes the first rocker arm 121 and the second rocker arm 122, and one end of the first rocker arm 121 is fixed on
In driving mechanism 110, the direction that the other end of the first rocker arm 121 is directed away from driving mechanism 110 extends, the second rocker arm 122
One end also is secured in driving mechanism 110, and the direction that the other end of the second rocker arm 122 is also directed away from driving mechanism 110 extends.
First fixing end is located on first one end of rocker arm 121 far from driving mechanism 110, and it is remote that the second fixing end is located at the second rocker arm 122
On one end from driving mechanism 110.First reagent needle 131 is fixed in the first fixing end of the first rocker arm 121, the second reagent needle
132 are fixed in the second fixing end of the second rocker arm 122.Moreover, one end that the first rocker arm 121 is connect with driving mechanism 110 and
One end that second rocker arm 122 is connect with driving mechanism 110 is overlapped, i.e. the first rocker arm 121 is coplanar with the second rocker arm 122, this
Sample enables to the first reagent needle 131 and the second reagent needle 132 to be in sustained height, facilitates execution to draw and grasps with discharge reagent
Make.Driving mechanism 110 is able to drive the first rocker arm 121 and the second rocker arm 122 makes rotating motion and elevating movement, and then first shakes
Arm 121 drives the movement of the first reagent needle 131, and the second rocker arm 122 drives reagent needle movement, so that the first reagent needle 131 and second
Reagent needle 132 can move synchronously.
Specifically, heating mechanism is arranged in the first reagent needle 131 and/or the second reagent needle 132, i.e. the first reagent needle
131 and second at least one of the reagent needle 132 setting heating mechanism.Heating mechanism can be to the first reagent needle 131 and second
Reagent at least one of reagent needle 132 is heated.Heating mechanism can be individually to the reagent in the first reagent needle 131
It heated, heating individually carried out to the reagent in the second reagent needle 132 or to the first reagent needle 131 and the second reagent needle
Reagent in 132 is heated.Preferably, the first reagent needle 131 and the second reagent needle 132 have heating function, i.e. heater
Structure includes the first heating element and the second heating element, and the first heating element is set in the first reagent needle 131, for first
Reagent heating in reagent needle 131；Second heating element is set in the second reagent needle 132, for in the second reagent needle 132
Reagent heating.After first reagent needle 131 and the second reagent needle 132 draw the reagent in reagent storing mechanism, reagent is stored in
The inside of first reagent needle 131 and the second reagent needle 132, the first reagent needle 131 is by its first internal heating element to examination
Agent is heated, and the second reagent needle 132 heats reagent by its second internal heating element, and the temperature of reagent reaches
After preset temperature, then add reagent in the reaction cup of sample incubation device 300 or the reaction cup of sample testing apparatus 400,
The reaction speed for accelerating sample and reagent, improves the analysis efficiency of sample analysis apparatus.Also, the first heating element and second adds
Thermal part can also quickly and accurately heat the reagent in the first reagent needle 131 and the second reagent needle 132, and make reagent
Preset temperature is maintained, to guarantee the accuracy and high efficiency of test result.
Preferably, after the first reagent needle 131 is completed to the absorption of reagent, at this point, driving mechanism 110 drives fixed frame 120
Rotation, the first reagent needle 131 can at an arbitrary position heat reagent therein.Meanwhile second reagent needle 132 driving
Reagent is drawn on the lower suction reactant station that can turn to reagent storage means 200 of the driving of mechanism 110, turns to sample incubation dress
It sets reagent adding on 300 the first reagent adding station, turn to the examination that spues on the second reagent adding station on sample testing apparatus 400
Agent or the reagent in the second reagent needle 132 can also be heated.That is, the first reagent needle 131 is executing heating
When operation, the second reagent needle 132, which can execute, draws one or more of reagent, heating reagent, discharge reagent operation.Together
Reason, when the second reagent needle 132 heats reagent therein, aforesaid operations are also can be performed in the first reagent needle 131.Namely
It says, when executing heating operation, the first reagent needle 131 can execute to be drawn reagent, heating reagent, spues the second reagent needle 132
One or more of reagent operation.
Reagent adding device 100 of the invention realizes the transfer of reagent using the first reagent needle 131 and the second reagent needle 132,
So that the first reagent needle 131, while executing heating operation, the second reagent needle 132, which executes, to be drawn reagent, heating reagent, spues
Reagent operation realizes one of reagent needle when heated, and another reagent needle, which is able to carry out, to be drawn reagent, heating reagent, spues
One or more of reagent operation improves the utilization rate of driving mechanism 110, and then improves the efficiency of agent transfer, improves sample
The efficiency of this analytical equipment, so that sample analysis apparatus plays more preferably effect.
Preferably, line and the second fixing end and 120 center of fixed frame between 120 center of the first fixing end and fixed frame
Line angular range be 30 °~180 °.That is, the angle between the first rocker arm 121 and the second rocker arm 122 is 30 °
~180 °.The center of fixed frame 120 is at arrow meaning as shown in Figure 1.The first reagent needle 131 is enabled to execute in this way
When absorption or discharge reagent operation, the second reagent needle 132, which can deviate, inhales reactant station, the first reagent adding station or the second reagent adding
Station avoids the second reagent needle 132 from touching reagent storage means 200, sample incubation device 300 and sample testing apparatus 400, mentions
High 100 reliability of operation of reagent adding device, and then guarantee the service performance of sample analysis apparatus.Moreover, the first reagent needle 131
When executing absorption reagent, heating reagent and discharge reagent operation, the second reagent needle 132 can heat examination therein in the other end
Agent realizes that one of reagent needle another reagent needle when executing heating operation can work on, and resource utilization obtains greatly
Width is promoted, and improves the working efficiency of sample analysis apparatus.
In the present embodiment, the line between 120 center of the first fixing end and fixed frame and the second fixing end and fixed frame
Point on 120 center lines is conllinear.That is, the conllinear setting in the horizontal plane of the first rocker arm 121 and the second rocker arm 122, first
Fixing end and the second fixing end be located at the first rocker arm 121 and the second rocker arm 122 collinearly after distalmost end, i.e. the first reagent needle
131 and second the distance between reagent needle 132 be the first rocker arm 121 and the second rocker arm 122 length.In this way, the first reagent needle
131 when executing the operation for drawing reagent, discharge reagent space locating for the second reagent needle 132 holding with the second reagent needle 132
Space locating for the first reagent needle 131 is completely the same when row draws the operation of reagent, discharge reagent, conveniently keeps away setting for bit space
Meter, optimizes the complete machine structure of sample analysis apparatus, so that the position of the first reagent needle 131 and the second reagent needle 132 is more controllable, side
Just the control of reagent adding device 100.
As an embodiment, driving mechanism 110 includes shaft 111, the first driving assembly 112 and the second driving group
Part 113, fixed frame 120 are set in shaft 111, and the first driving assembly 112 is installed on the second driving assembly 113, and first drives
Dynamic component 112 is connect with shaft 111 with the second driving assembly 113, and the first driving assembly 112 is done for drive shaft 111 to be revolved
Transhipment is dynamic, and the second driving assembly 113 is moved up and down for drive shaft 111.Shaft 111 is connect with fixed frame 120, i.e. shaft
First rocker arm 121 and the second rocker arm 122 are installed respectively, 112 drive shaft 111 of the first driving assembly rotates, then shaft on 111
111 drive the first rocker arms 121 make rotating motion with the second rocker arm 122 so that the first reagent needle 131 with 132 turns of the second reagent needle
The corresponding position of sample analysis apparatus is moved, corresponding operating is executed.Second driving assembly, 113 drive shaft 111 moves up and down,
Then shaft 111 drives the first rocker arm 121 to move up and down with the second rocker arm 122；Second driving assembly, 113 drive shaft 111
When the first reagent needle 131 and the second reagent needle 132 being driven to do descending motion, the first reagent needle 131 and the second reagent needle 132 can
Execute and draw or discharge reagent operation, after the completion, the second driving assembly 113 again drive shaft 111 drive the first reagent needle 131 with
Second reagent needle 132 does ascending motion；Then, 112 drive shaft 111 of the first driving assembly drives the first reagent needle 131 and the
Two reagent needles 132 turn to corresponding position and execute corresponding operating.
Certainly, in other embodiments of the invention, driving mechanism 110 can also be operated alone the first reagent needle 131 and
The rotation of second reagent needle 132.That is, driving mechanism 110 drive the first reagent needle 131 rotation when execute draw reagent,
When heating one or more of reagent, discharge reagent operation, the second reagent needle 132, which remains static, carries out heating reagent；
On the contrary, driving mechanism 110 is executed when driving the rotation of the second reagent needle 132 draws reagent, heating reagent, in discharge reagent operation
One or more when, the first reagent needle 131, which remains static, carries out heating reagent.
Specifically, the first driving assembly 112 includes the first driving motor 1121 and the first transmission parts 1122.First driving
Motor 1121 is installed on support frame 140, and the first transmission parts 1122 are installed in the first driving motor 1121 and shaft 111,
The output shaft and shaft 111 of first transmission parts 1122 the first driving motor 1121 of transmission connection, are rotated with drive shaft 111 and are transported
It is dynamic, and then shaft 111 drives the first reagent needle 131 and the second reagent needle 132 on fixed frame 120 to make rotating motion.Second drives
Dynamic component 113 includes the second driving motor 1131 and the second transmission parts 1132.Second driving motor 1131 is installed on support frame
On 140, the second transmission parts 1132 are installed on the second driving motor 1131 in shaft 111, and the second transmission parts 1132 are driven
The output shaft and shaft 111 for connecting the second driving motor 1131, are moved up and down with drive shaft 111, so that shaft 111
The first reagent needle 131 and the second reagent needle 132 on fixed frame 120 is driven to move up and down.Optionally, the first transmission parts
1122 and second transmission parts 1132 can be synchronous belt transfer structure, it is, of course, also possible to for the realizations fortune such as chain drive structure
The structure of dynamic transmitting.
The detailed process of 131 transfering reagent of the first reagent needle is explained in detail below: when the first reagent 131 transfering reagent of needle, first
112 drive shaft 111 of driving assembly drives the first rocker arm 121 and the second rocker arm 122 to rotate, so that the first rocker arm 121 drive the
One reagent needle 131 turns at the suction reactant station of reagent storage means 200；Then, 113 drive shaft of the second driving assembly
111 drive the decline of the first rocker arm 121, and then the first rocker arm 121 drives the decline of the first reagent needle 131, at this point, the first reagent needle
131 are inhaling reactant station absorption reagent；After having drawn reagent, drive shaft 111 drives the first rocker arm to the second driving assembly 113 again
121 rise, and then the first rocker arm 121 drives the first reagent needle 131 to rise；Then, the first reagent needle 131 passes through the first heating part
Part heats reagent therein, and after the temperature in the first reagent needle 131 reaches preset temperature, the first reagent needle 131 can
Reagent operation is added to execute, at this point, 112 drive shaft 111 of the first driving assembly drives the rotation of the first rocker arm 121, then the
One rocker arm 121 drives the first reagent needle 131 to turn at the first reagent adding station of sample incubation device 300 or turn to magnetic bead
At the third reagent adding station of method testing agency.When the first reagent needle 131 turns to the first reagent adding of sample incubation device 300
After at station, 113 drive shaft 111 of the second driving assembly drives the decline of the first rocker arm 121, and then the first rocker arm 121 drives the
The decline of one reagent needle 131, the first reagent needle 131 spue examination in the first reagent adding station into the reaction cup of sample incubation module
Agent；After having added reagent, 113 drive shaft 111 of the second driving assembly drives the first rocker arm 121 to rise, and then the first rocker arm 121
Reagent needle is driven to rise.At the third reagent adding station that the first reagent needle 131 turns to paramagnetic particle method testing agency；Second driving
113 drive shaft 111 of component drives the decline of the first rocker arm 121, and then the first rocker arm 121 drives the decline of the first reagent needle 131, the
One reagent needle 131 spues reagent in third reagent adding station into the reaction cup of paramagnetic particle method testing agency；After having added reagent, the
Two driving assemblies, 113 drive shaft 111 drives the first rocker arm 121 to rise, and then the first rocker arm 121 drives the first reagent needle 131
Rise.
It should be noted that the course of work of the course of work of the second reagent needle 132 and position and the first reagent needle 131 and
Position is identical, and the first reagent needle 131 is when heating reagent therein by the first heating element, the first driving assembly 112
Drive shaft 111 drives the second reagent needle 132 to turn to suction reactant station, the first reagent adding station or the second reagent adding station and holds
Row and the first similarly operation of reagent needle 131, at this point, without the position for managing the first reagent needle 131, when the second reagent needle 132
When heating reagent therein by the second heating element, after the completion of the reagent heating in the first reagent needle 131, the first driving assembly
112 the first reagent needles 131 of driving turn to the first reagent adding station or the second reagent adding station executes corresponding operating, are not necessarily at this time
Manage the position of the second reagent needle 132.Operation is looped back and forth like this, realizes the transfer of reagent, improves operating efficiency.
Moreover, there is no limit can first add in reaction cup the sequence of addition sample and reagent in sample incubation device 300
It is loaded this, then again by 100 discharge reagent of reagent adding device；Certainly, can also first spue in reaction cup reagent, then add again
Sample.At this point, reagent adding device 100 of the invention can be shifted reagent by reagent adding device 100 from reagent storage means 200
Into the reaction cup added with sample of sample incubation device 300, the sky of sample incubation device 300 can also be added reagent on again
In reaction cup, in use, reaction cup that can be adaptable according to actual use demand selection.
Optionally, reagent adding device 100 further includes control mechanism 150, and control mechanism 150 includes the first temperature control mainboard 151
And the second temperature control mainboard 152, the first temperature control mainboard 151 and the second temperature control mainboard 152 are respectively arranged on fixed frame 120.First
Temperature control mainboard 151 is electrically connected with the first heating element, and the first temperature control mainboard 151 adds reagent for controlling the first heating element
Hot temperature；Second temperature control mainboard 152 is electrically connected with the second heating element, and the first temperature control mainboard 152 is for controlling the second heating part
Heating temperature of the part to reagent.First temperature control mainboard 151 and the second temperature control mainboard 152 can guarantee the first reagent needle 131 and
Real reagent in two reagent needles 132 quickly and accurately heats and maintains preset temperature, guarantees the accuracy of test result
And high efficiency.Preferably, the first heating element and the second heating element can be heater strip, certainly, the first heating element and the
Two heating elements can also can be realized the structure of heating function for other.
Further, control mechanism 150 further includes the first detection mainboard 153 and the second detection mainboard 154, the first detection master
Plate 153 and the second detection mainboard 154 are all set on fixed frame 120.First detection mainboard 153 is electrically connected with the first reagent needle 131
It connects, the first detection mainboard 153 is used to detect the liquid level in the reagent bottle of the first reagent needle 131 absorption reagent；Second detection
Mainboard 154 is electrically connected with the second reagent needle 132, and the second detection mainboard 154 is used to detect the examination that the second reagent needle 132 draws reagent
Liquid level in agent bottle, such control mechanism 150 can according to the first reagent needle 131 of height control of liquid level in reagent bottle with
The lower depth pricked of the distance that second reagent needle 132 moves downward, i.e. the first reagent needle 131 and the second reagent needle 132；Meanwhile when
When liquid level in reagent bottle is too low, moreover it is possible to which prompt replaces reagent bottle in time or adds reagent into reagent bottle, guarantees equipment
It operates normally.Optionally, the first level sensing component, the first level sensing component and the first inspection are set in the first reagent needle 131
It surveys mainboard 153 to be electrically connected, liquid level locating for 131 end of the first reagent needle is judged by the first level sensing component；Second reagent
Second level sensing component is set in needle 132, and the second level sensing component is electrically connected with the second detection mainboard 154, passes through second
Level sensing component judges liquid level locating for 132 end of the second reagent needle.Preferably, the first level sensing component and the second liquid level
Detection part can be sensor, certainly, can also can be realized the structure of level sensing for other.
Moreover, the first temperature control mainboard 151 and the first detection mainboard 153 are oppositely arranged on the first rocker arm 121 of fixed frame 120
On, there are space between the first temperature control mainboard 151 and the first detection mainboard 153, facilitate the first reagent needle 131 other pipelines,
The cabling of electric wire etc. saves space, guarantees that structure is neatly orderly.Second temperature control mainboard 152 is opposite with the second detection mainboard 154 to be set
It sets on the second rocker arm 122 of fixed frame 120, there are space, sides between the second temperature control mainboard 152 and the second detection mainboard 154
Just the cabling of other pipelines, electric wire of the second reagent needle 132 etc. saves space, guarantees that structure is neatly orderly.
It is the first reagent needle 131 and the second reagent needle in the reagent adding device 100 of one embodiment of the invention referring to Fig. 3, Fig. 3
132 fluid path figure.Optionally, reagent adding device 100 further includes wiper mechanism 160.Wiper mechanism 160 is used for the first reagent needle
131 are cleaned with the second reagent needle 132.In order to avoid the first reagent needle 131 and the second reagent needle 132 are dirty in transfering reagent
Sample is contaminated, is required after 132 reagent of every transfer of the first reagent needle 131 and the second reagent needle to the first reagent needle 131 and the
Two reagent needles 132 are cleaned, and are avoided mutually infecting between sample and reagent and are avoided mutually infecting between different reagents, are protected
Demonstrate,prove the reliability of sample analysis apparatus detection.Specifically, wiper mechanism 160 includes cleaning supervisor the 161, first cleaning branch pipe 162
And second cleaning branch pipe 163, cleaning supervisor 161, first cleaning branch pipe 162 and second cleaning branch pipe 163 be all set in fixed frame
On 120.One end of first cleaning branch pipe 162 is connected to the first reagent needle 131, the other end of the first cleaning branch pipe 162 and cleaning
161 connection of supervisor；One end of second cleaning branch pipe 163 is connected to the second reagent needle 132, the other end of the second cleaning branch pipe 163
It is connected to cleaning supervisor 161.First cleaning branch pipe 162 is for cleaning the first reagent needle 131, the second cleaning branch pipe 163
For being cleaned to the second reagent needle 132.Cleaning supervisor 161 connects liquid source, liquid source far from one end of the first cleaning branch pipe 162
Cleaning solution in liquid source can be transported to the first reagent needle through the first cleaning branch pipe 162 by middle storage cleaning solution, cleaning supervisor 161
In 131, it is transported in the second reagent needle 132 through the second cleaning branch pipe 163.Moreover, the first cleaning branch pipe 162 and the second cleaning branch
Pipe 163 shares cleaning supervisor 161, is divided by a cleaning supervisor 161 to the first cleaning branch pipe 162 and the second cleaning branch pipe 163
Indescribably reach cleaning so that cleaning solution is transported to respectively in the first reagent needle 131 and the second reagent needle 132 for cleaning solution
The purpose of first reagent needle 131 and the second reagent needle 132, while also can be reduced the quantity of pipeline, and then reduce the complexity of structure
Degree.Also, the first cleaning branch pipe 162 is set to the space between the first temperature control mainboard 151 and the first detection mainboard 153, the
Two cleaning branch pipes 163 are set to the space between the second temperature control mainboard 152 and the second detection mainboard 154,161 setting of cleaning supervisor
In shaft 111.
Further, setting cleaning main valve 164 on cleaning supervisor 161, first cleans the first cleaning of setting branch on branch pipe 162
Valve 165, meanwhile, the first cleaning branch valve 165 is located between cleaning main valve 164 and the first reagent needle 131；Second cleaning branch pipe 163
Upper the second cleaning of setting branch valve 166, meanwhile, the second cleaning branch valve 166 is located between cleaning main valve 164 and the second reagent needle 132.
Cleaning main valve 164 is used to control the on-off of cleaning supervisor 161, and the first cleaning branch valve 165 is used to control the first cleaning branch pipe 162
On-off, the second cleaning branch valve 166 are used to control the on-off of the second cleaning branch pipe 163.Wherein, main valve 164 and the first cleaning are cleaned
Branch valve 165 is opened, and the second cleaning branch valve 166 is closed, to control the cleaning of the first reagent needle 131.When the first reagent needle 131 executes
When cleaning operation, the second cleaning branch valve 166 is closed, and cleans main valve 164 and the first cleaning branch valve 165 is opened, cleaning solution passes through clear
It washes supervisor 161 and the first cleaning branch pipe 162 enters the first reagent needle 131 and carries out cleaning operation, after the completion of cleaning, close cleaning master
Valve 164 closes the first cleaning branch valve 165 after liquid stream to be cleaned is most.
In addition, wiper mechanism 160 further includes pump 167, pump 167 is set on cleaning supervisor 161, and is located at cleaning main valve
164 and first clean between branch valve 165 and the second cleaning branch valve 166.For example, cleaning main valve when the first cleaning branch valve 165 is opened
164 and second cleaning branch valve 166 close, pass through pump 167 control the first reagent needles 131 draw or discharge reagent.When the first reagent
When needle 131 executes absorption or discharge reagent operation, cleans main valve 164 and the second cleaning branch valve 166 is closed, the first cleaning branch valve
165 open, and draw reagent or discharge reagent by pump 167.When drawing reagent, reagent is stored in the first reagent needle 131.Again
Further, it cleans main valve 164 and the first cleaning branch valve 165 is turned off, heat reagent to control the first reagent needle 131.When
When one reagent needle 131 heats reagent therein, cleans main valve 164 and the first cleaning branch valve 165 is closed, reagent is avoided to flow to cleaning
The first reagent needle 131 of supervisor 161 or outflow.
Referring to fig. 4 and Fig. 5, Fig. 4 be one embodiment of the invention reagent adding device 100 work flow diagram, Fig. 5 Fig. 4
Shown in 132 work flow diagram of the first reagent needle 131 and the second reagent needle.The present invention also provides a kind of reagent adding devices 100
Control method, applied to the reagent adding device 100 of above-described embodiment, the control method of reagent adding device 100 includes the following steps:
Step S1: the fixed frame 120 of reagent adding device 100 drives the first reagent needle 131 and the second reagent needle 132 to go up and down
Movement and rotary motion, the first reagent needle 131 execute cleaning, draw reagent, heating reagent and discharge reagent operation and the second examination
Agent needle 132 executes cleaning, draws reagent, heating reagent and discharge reagent operation.
When reagent in the S2: the first reagent of step needle 131 is heated, the second reagent needle 132 turns to corresponding position and holds
Reagent, heating one of reagent and discharge reagent or multiple combinations operation are drawn in row cleaning.
In transfering reagent, the driving mechanism 110 of reagent adding device 100, which drives, is fixed reagent adding device 100 of the invention
Frame 120 drives the first reagent needle 131 and the second reagent needle 132 moves up and down and rotary motion so that the first reagent needle 131 with
Second reagent needle 132 executes cleaning, draws reagent, heating reagent and discharge reagent operation, the first reagent needle 131 and the second reagent
Needle 132 executes the operating process above content of aforesaid operations it is stated that just not repeating one by one herein.
It is understood that first cleaning operation would generally be executed to the first reagent needle 131 before drawing reagent, clean
Cheng Hou, driving mechanism 110 drive the first reagent needle 131 to turn to suction reactant station and draw reagent；First reagent needle 131 is drawn
After reagent and when heating to reagent therein, driving mechanism 110 can drive fixed frame 120 to rotate, so that the second reagent
Needle 132 turns to washing station and carries out cleaning operation, turns on the suction reactant stations of reagent storage means 200 and draw reagent,
Or second reagent needle 132 turn to sample incubation device 300 the first reagent adding station or sample testing apparatus 400 second
Reagent adding station, also or, the second reagent needle 132 also executes corresponding heating operation, certain second reagent after drawing reagent
Needle 132 can also be the combination for executing cleaning, drawing reagent, heating reagent and a variety of operations of discharge reagent.
Optionally, when the reagent in the second reagent needle 132 is heated, the first reagent needle 131 turns to corresponding position and holds
Reagent, heating one of reagent and discharge reagent or multiple combinations operation are drawn in row cleaning.Second reagent needle 132 draws examination
When heating after agent to reagent therein, driving mechanism 110 can drive the first reagent needle 131 to turn to washing station progress
Cleaning operation can drive the first reagent needle 131 to turn on the suction reactant station of reagent storage means 200 and draw reagent,
The first reagent needle 131 can be driven to turn to the first reagent adding station or sample testing apparatus 400 of sample incubation device 300
Second reagent adding station can drive the first reagent needle 131 also to execute corresponding heating operation after drawing reagent, can also drive
The combination that dynamic first reagent needle 131 executes cleaning, draws reagent, heats reagent and a variety of operations of discharge reagent.Such as say, it executes
Cleaning operation and absorption reagent operation；Reagent operation, heating reagent operation, discharge reagent operation and cleaning are drawn alternatively, executing
Operation；Alternatively, executing cleaning operation, drawing reagent operation, heating reagent operation and discharge reagent operation etc..
Further, when the second reagent needle 132 executes multiple combinations operation, the second reagent needle 132 is according to cleaning, absorption
The circulation execution that puts in order of reagent, heating reagent, discharge reagent.
That is, the operation that the second reagent needle 132 executes is according to cleaning, draws reagent, heating reagent, discharge reagent
Sequence circulation executes；Moreover, the first reagent needle 131 is also according to clear when the first reagent needle 131 executes multiple combinations operation
Wash, draw the circulation execution that puts in order of reagent, heating reagent, discharge reagent.
In a kind of specific embodiment of the present invention, step S10: driving mechanism 110 drives the rotation of the first reagent needle 131
To washing station, and execute cleaning operation；After the completion of the cleaning of first reagent needle 131, step S11 is executed, driving mechanism 110 drives
First reagent needle 131, which turns to, draws reagent at the suction reactant station of reagent storage means 200；After the completion of absorption, step is executed
S12, the first reagent needle 131 heat reagent therein, meanwhile, step S13 is executed, driving mechanism 110 drives the second reagent needle 132
Turn to washing station；After the completion of the cleaning of second reagent needle 132, step S14 is executed, driving mechanism 110 drives the second reagent needle
The 132 suction reactant stations for turning to reagent storage means 200 draw reagent；After second reagent needle 132 has drawn reagent, step is executed
Rapid S15, the second reagent needle 132 heat reagent therein；Meanwhile after the first reagent in reagent needle 131 is heated to required temperature,
Step S16 is executed, the first reagent needle 131 of driving of driving mechanism 110 turns to the first reagent adding station of sample incubation device 300
Or at the second reagent adding station of sample testing apparatus 400；First reagent needle 131 spues after reagent therein, executes step
S17, driving mechanism 110 drive the first reagent needle 131 to turn to washing station and execute cleaning operation；After the completion of cleaning, when second
After needed for the temperature of reagent is heated in reagent needle 132, step S18 is executed, driving mechanism 110 drives 132 turns of the second reagent needle
It moves at the first reagent adding station of sample incubation device 300 or the second reagent adding station of sample testing apparatus 400；Second examination
Agent needle 132 spues reagent therein, executes step S19, drives the second reagent needle 132 to turn to cleaning with rear drive mechanism 110
Station executes cleaning operation；When reagent also needs to heat in the second reagent needle 132, at this point, driving mechanism 110 can drive
One reagent needle 131, which executes, draws reagent, heating reagent operation, executes step S10 to step S12.When reagent adding device 100 repeats
When transfering reagent, the first reagent needle 131 and the second reagent needle 132 are executed according to step S10 to step S19 sequence circulation, so that
First reagent needle 131 is used alternatingly with the second reagent needle 132.It should be noted that the second reagent needle 132 heats reagent therein
When, the first reagent needle 131, which sequentially executes several steps, to be determined by the heating time of the second reagent needle 132.Such as the second examination
The heating time of agent needle 132 is shorter, and the first reagent needle 131 may can only execute cleaning operation or execute cleaning and draw reagent
Operation etc.；When the second reagent needle 132 heating volume heating time is longer, the first reagent needle 131 may execute cleaning, inhale
It takes reagent and heating reagent operation or executes cleaning, draws reagent, heating reagent and discharge reagent operation.
In this way, the first reagent needle 131, while heating wherein reagent, the second reagent needle 132 is able to carry out cleaning, draws
Reagent, the operation for heating reagent and discharge reagent, the second reagent needle 132 is while heating wherein reagent, the first reagent needle 131
The operation for being able to carry out cleaning, drawing reagent, heating reagent and discharge reagent, so that one of reagent needle is executing heating examination
When agent operates, another reagent needle is able to carry out other operations, i.e., another reagent needle is able to carry out various movements, so that the first reagent
Needle 131 and the second reagent needle 132 are not at idle state, the utilization rate of driving mechanism 110 are improved, so that resource utilization is big
Width is promoted, and then improves the working efficiency of sample analysis apparatus.
Certainly, in other embodiments of the invention, the first reagent needle 131 can also sequentially be held with the second reagent needle 132
Row, i.e. after the first reagent needle 131 sequentially executes cleaning, draws reagent, heating reagent and discharge reagent operation, the second reagent needle
132 sequentially execute cleaning again, draw reagent, heating reagent and discharge reagent operation.It also can be realized the transfer of reagent in this way.
It is the work flow diagram of the first reagent needle 131 work referring to Fig. 3 and Fig. 6, Fig. 6.As a kind of possible embodiment party
Formula, when the first reagent needle 131 executes cleaning operation, the cleaning fluid path of the first reagent needle 131 is connected, after the completion of cleaning, cleaning solution
Road disconnects；
When first reagent needle 131 executes absorption reagent operation, the compressing fluid path of the first reagent needle 131 is connected, and draws reagent
After the completion, compressing fluid path disconnects；
When first reagent needle 131 executes discharge reagent operation, the compressing fluid path of the first reagent needle 131 is connected, discharge reagent
After the completion, compressing fluid path disconnects.
The compressing fluid path of first reagent needle 131 connects the first cleaning branch pipe 162 for referring to the first reagent needle 131 and thereon
First cleaning branch valve 165, the on-off of first cleaning branch valve 165 control the first cleaning branch pipe 162；And cleaning fluid path includes compressing liquid
Road is responsible for 161 with the cleaning for being connected to compressing fluid path.When cleaning, cleaning fluid path is provided by cleaning supervisor 161 to compressing fluid path clear
Washing lotion, after the completion of cleaning, the cleaning supervisor 161 for cleaning fluid path is closed, and completes cleaning operation.First reagent needle 131 draw or
When discharge reagent, compressing fluid path can draw convenient for the first reagent needle 131 or discharge reagent.When heating, compressing reagent is in envelope
Closed state avoids the occurrence of leakage problem.
Illustrate the cleaning fluid path of the first reagent needle 131 and the on-off of compressing fluid path by taking the first reagent needle 131 as an example.First examination
Agent needle 131 executes step S30 when executing cleaning operation, and the first cleaning branch valve 165 is opened, and the second cleaning branch valve 166 is closed,
Then step S31 is executed, cleaning main valve 164 is opened, executes step S32, cleaning solution is passed through to the first reagent needle 131 and tries first
Agent needle 131 carries out cleaning operation；After cleaning, step S33 is executed, closes cleaning main valve 164, at this point, the first cleaning branch valve
165 is in the open state, and the second cleaning branch valve 166 is in close state, and executes step S34, and the first reagent needle 131 draws examination
Agent executes step S35 after the completion of drawing, and closes the first cleaning branch valve 165.Step S36 is then executed, the first reagent needle 131 is held
Row heating operation；After the completion of heating, step S37 is executed, opens the first cleaning branch valve 165, the second cleaning branch valve 166 is still within
Closed state, executes step S38, and the first reagent needle 131 executes the operation of discharge reagent.Then, cleaning main valve 164 is opened, to
First reagent needle 131 is passed through cleaning solution and carries out cleaning operation to the first reagent needle 131；After cleaning, cleaning main valve is closed
164.It loops back and forth like this, the operation for realizing the cleaning of the first reagent needle 131, drawing reagent, heating reagent, discharge reagent.When
When reagent adding device 100 stops working, after the first reagent needle 131 cleans, cleaning main valve 164 is closed, it is clear to turn off first
Wash branch valve 165.It should be noted that the second reagent needle 132 is identical as the control mode of the first reagent needle 131, it is just different herein
One repeats.
Referring to Fig. 1 and Fig. 2, the present invention also provides a kind of sample analysis apparatus, including sample incubation device 300, reagent to deposit
Reagent adding device 100 in storage device 200, sample testing apparatus 400 and above-described embodiment.Sample incubation device 300 and examination
Agent storage device 200 is arranged side by side, and sample testing apparatus 400 is set to sample incubation device 300 and reagent storage means 200
Side, reagent adding device 100 are set to 400 three of sample incubation device 300, reagent storage means 200 and sample testing apparatus
Between, reagent adding device 100 can examine the agent transfer in reagent storage means 200 to sample incubation device 300 or sample
It surveys on device 400.This realizes reagent in sample incubation device 300, reagent storage means 200 and sample by reagent adding device 100
Transfer between this detection device 400, to realize that sample analysis apparatus detects sample.Sample analysis apparatus further includes turning
Moving device and agitating device, transfer device are used for transfer reaction cup, and empty reaction cup is transferred on sample incubation device 300,
It is transferred on sample testing apparatus 400 by the reaction cup for adding sample and reagent, agitating device is for being stirred to react in cup
Sample and reagent guarantee that testing result is accurate so that sample is uniformly mixed with reagent.
Further, when one of reagent needle of reagent adding device 100 draws reagent in reagent storage means 200,
Bit space is kept away for first in space locating for another reagent needle.One of reagent needle of reagent adding device 100 is filled in sample incubation
When setting discharge reagent on 300, bit space is kept away for second in space locating for another reagent needle.One of them of reagent adding device 100
For reagent needle in 400 discharge reagent of sample testing apparatus, space locating for another reagent needle is that third keeps away bit space.Reagent adding dress
100 one of reagent needle is set in cleaning, space locating for another reagent needle is the 4th to keep away bit space.
Since reagent adding device 100 is double end needle construction, reagent adding device 100 may be anti-with transfer in transfering reagent
It answers the components such as transfer device, agitating device, sample incubation device 300 and the reagent storage means 200 of cup to interfere, causes
Sample analysis apparatus is shut down, it is therefore desirable to the bit space of keeping away of the first reagent needle 131 and the second reagent needle 132 is defined, when
When first reagent needle 131 executes operation, the second reagent needle 132 should be at keeping away in bit space, correspondingly, the second reagent needle 132 is held
When row corresponding operating, the first reagent needle 131 also should be at keeping away in bit space, guarantee 100 reliable operation of reagent adding device, Jin Erti
The reliability of high sample analysis apparatus work.Specifically, when the first reagent needle 131 draws reagent in taking reactant station, second
Bit space is kept away for first in space locating for reagent needle 132.Suction reactant station of the first reagent needle 131 in reagent storage means 200
When upper absorption reagent, the second reagent needle 132 has at the A shown in 2 keeps away bit space, and transfer device is needed to the second reagent needle
132 carry out keeping away position, avoid colliding, while the second reagent needle 132 being avoided to interfere when going up and down with other components.First
For reagent needle 131 in reagent adding on the first reagent adding station, bit space is kept away for second in space locating for the second reagent needle 132.The
For one reagent needle 131 when adding reagent on the first reagent adding station on sample incubation device 300, the second reagent needle 132 is in Fig. 2
Shown in have at B and keep away bit space, avoid colliding, while the second reagent needle 132 being avoided to send out when going up and down with other components
Raw interference.First reagent needle 131 in the first reagent adding station reagent adding, keep away for third by space locating for the second reagent needle 132
Bit space.First reagent needle 131 is when adding reagent on the second reagent adding station on sample testing apparatus 400, the second reagent
Have at the C shown in Fig. 2 of needle 132 and keep away bit space, avoid colliding, while the second reagent needle 132 being avoided to go up and down Shi Yuqi
He interferes components.For first reagent needle 131 when being cleaned, position is kept away for the 4th in space locating for the second reagent needle 132
Space.First reagent needle 131 has at the second reagent needle 132 B shown in Fig. 2 in cleaning and keeps away bit space, avoid touching
It hits, while the second reagent needle 132 being avoided to interfere when going up and down with other components.It should be noted that the second reagent needle 132
When executing aforesaid operations, the first reagent needle 131 also keeps away bit space with above-mentioned.
Optionally, sample analysis apparatus further includes waterproof part (not shown), and sample testing apparatus 400 is examined including paramagnetic particle method
Mechanism is surveyed, waterproof part covers between paramagnetic particle method testing agency and reagent storage means 200.In order to avoid the first reagent needle
131 and second reagent needle 132 surface on the reagent that picks drop onto control mainboard in paramagnetic particle method testing agency, examined in paramagnetic particle method
It surveys between mechanism and reagent storage means 200 and increases waterproof part, waterproof part plays impermeable role, and water is avoided to drip.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the record scope of this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (17)
1. a kind of reagent adding device characterized by comprising
Driving mechanism, the driving structure is for exporting rotary motion and reciprocal elevating movement；
Fixed frame, is connected to the driving mechanism, and the driving mechanism drives the fixed frame to do reciprocal elevating movement and rotation
Movement, the fixed frame include the first fixing end and the second fixing end；
Reagent needle mechanism, including the first reagent needle and the second reagent needle, the first reagent needle are set to first fixing end
On, the second reagent needle is set in second fixing end；
Heating mechanism, for being heated at least one of the first reagent needle and the second reagent needle；And
Support frame connects and supports the fixed frame.
2. reagent adding device according to claim 1, which is characterized in that first fixing end and the fixed frame center
Between line and 30 °~180 ° of angular range of line of second fixing end and the fixed frame center.
3. reagent adding device according to claim 2, which is characterized in that first fixing end and the fixed frame center
Between line and the angle of second fixing end and the fixed frame line of centres be 180 °.
4. reagent adding device according to any one of claims 1 to 3, which is characterized in that the heating mechanism includes first
Heating element and the second heating element, first heating element are used to heat the reagent in the first reagent needle；It is described
Second heating element is used to heat the reagent in the second reagent needle.
5. reagent adding device according to claim 4, which is characterized in that the reagent adding device further includes control mechanism,
The control mechanism includes the first temperature control mainboard and the second temperature control mainboard, the first temperature control mainboard and the second temperature control mainboard
It is respectively arranged on the fixed frame；
The first temperature control mainboard is electrically connected with first heating element, for controlling first heating element to reagent
Heating temperature；The second temperature control mainboard is electrically connected with second heating element, for controlling second heating element pair
The heating temperature of reagent.
6. reagent adding device according to claim 5, which is characterized in that the control mechanism further includes the first detection mainboard
And second detection mainboard, it is described first detection mainboard and it is described second detection mainboard is all set on the fixed frame；
The first detection mainboard is used to detect the liquid level in the reagent bottle of the first reagent needle absorption reagent；Described
Two detection mainboards are used to detect the liquid level in the reagent bottle of the second reagent needle absorption reagent.
7. reagent adding device according to any one of claims 1 to 3, which is characterized in that the reagent adding device further includes
Wiper mechanism, the wiper mechanism include cleaning supervisor, the first cleaning branch pipe and the second cleaning branch pipe；
It is described first cleaning branch pipe one end be connected to the first reagent needle, it is described first clean branch pipe the other end with it is described
Cleaning supervisor's connection；One end of the second cleaning branch pipe is connected to the second reagent needle, and described second cleans the another of branch pipe
One end is connected to cleaning supervisor.
8. reagent adding device according to claim 7, which is characterized in that setting cleaning main valve, institute on the cleaning supervisor
The first cleaning of setting branch valve on the first cleaning branch pipe is stated, setting the second cleaning branch valve on the second cleaning branch pipe；Wherein,
The cleaning main valve and the first cleaning branch valve are opened, and the second cleaning branch valve is closed, to control first examination
The cleaning of agent needle；
The first cleaning branch valve is opened, and the cleaning main valve and the second cleaning branch valve are closed, to control first examination
Agent needle is drawn or discharge reagent.
9. reagent adding device according to claim 8, which is characterized in that the cleaning main valve and the first cleaning branch valve
It is turned off, to control the heating of reagent in the first reagent needle.
10. reagent adding device according to claim 1, which is characterized in that the driving mechanism includes shaft, the first driving
Component and the second driving assembly, for the fixed mount setting in the shaft, first driving assembly is installed on described second
On driving assembly, first driving assembly is connect with the shaft with second driving assembly, first driving group
Part is for driving the shaft to make rotating motion, and second driving assembly is for driving the shaft to move up and down.
11. a kind of control method of reagent adding device, which comprises the steps of:
The fixed frame of reagent adding device drives the first reagent needle and the second reagent needle moves up and down and rotary motion, and described first
Reagent needle and the second reagent needle execute cleaning, draw reagent, heating reagent and discharge reagent operation；
When reagent in the first reagent needle is heated, the second reagent needle turns to corresponding position and executes cleaning, inhales
Take reagent, heating one of reagent and discharge reagent or multiple combinations operation.
12. the control method of reagent adding device according to claim 11, which is characterized in that when the second reagent needle is held
When row multiple combinations operate, the second reagent needle according to cleaning, draw reagent, heating reagent, discharge reagent and put in order
Circulation executes.
13. the control method of reagent adding device according to claim 11, which is characterized in that in the second reagent needle
When reagent is heated, the first reagent needle turns to corresponding position sequence and executes discharge reagent, cleaning, draws reagent and add
One of thermal agent or multiple combinations operation.
14. the control method of 1 to 13 described in any item reagent adding devices according to claim 1, which is characterized in that described first
When reagent needle executes cleaning operation, the cleaning fluid path of the first reagent needle is connected, and after the completion of cleaning, the cleaning fluid path is disconnected
It opens；
When the first reagent needle executes absorption reagent operation, the compressing fluid path of the first reagent needle is connected, and it is complete to draw reagent
Cheng Hou, the compressing fluid path disconnect；
When the first reagent needle executes discharge reagent operation, the compressing fluid path of the first reagent needle is connected, and discharge reagent is complete
Cheng Hou, the compressing fluid path disconnect.
15. a kind of sample analysis apparatus, which is characterized in that including sample incubation device, reagent storage means, sample testing apparatus
And reagent adding device as described in any one of claim 1 to 10；
The sample incubation device and the reagent storage means are arranged side by side, and the sample testing apparatus is set to the sample
The side of incubating device and the reagent storage means, the reagent adding device are set to the sample incubation device, the examination
Between agent storage device and the sample testing apparatus three, the reagent adding device can will be in the reagent storage means
In agent transfer to the sample incubation device or the sample testing apparatus.
16. sample analysis apparatus according to claim 15, which is characterized in that the first reagent needle of the reagent adding device
When drawing reagent in the reagent storage means, bit space is kept away for first in space locating for the second reagent needle；
The first reagent needle of the reagent adding device is in discharge reagent on the sample incubation device, second reagent
Bit space is kept away for second in space locating for needle；
The first reagent needle of the reagent adding device is in the sample testing apparatus discharge reagent, the second reagent needle
Locating space is that third keeps away bit space；
For the first reagent needle of the reagent adding device in cleaning, position is kept away for the 4th in space locating for the second reagent needle
Space.
17. sample analysis apparatus according to claim 15, which is characterized in that the sample analysis apparatus further includes waterproof
Component, the sample testing apparatus include paramagnetic particle method testing agency, and the waterproof part covers at the paramagnetic particle method testing agency
Between the reagent storage means.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710703970.1A CN109406799B (en) | 2017-08-16 | 2017-08-16 | Sample analysis apparatus, reagent adding device, and control method thereof |
| CN202210135263.8A CN114518466A (en) | 2017-08-16 | 2017-08-16 | Sample analysis apparatus, reagent adding device, and control method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710703970.1A CN109406799B (en) | 2017-08-16 | 2017-08-16 | Sample analysis apparatus, reagent adding device, and control method thereof |
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| CN202210135263.8A Division CN114518466A (en) | 2017-08-16 | 2017-08-16 | Sample analysis apparatus, reagent adding device, and control method thereof |
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| Publication Number | Publication Date |
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| CN109406799A true CN109406799A (en) | 2019-03-01 |
| CN109406799B CN109406799B (en) | 2022-03-04 |
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| CN110849701A (en) * | 2019-11-04 | 2020-02-28 | 山东见微生物科技有限公司 | Sample processing apparatus |
| CN112147346A (en) * | 2019-06-28 | 2020-12-29 | 深圳迈瑞生物医疗电子股份有限公司 | Sample adding needle temperature control method, calibration method and system thereof |
| WO2021134610A1 (en) * | 2019-12-31 | 2021-07-08 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis device and sample analysis method |
| WO2021134609A1 (en) * | 2019-12-31 | 2021-07-08 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzing apparatus |
| WO2022227723A1 (en) * | 2021-04-28 | 2022-11-03 | 深圳市亚辉龙生物科技股份有限公司 | Reagent transfer device and immunological diagnostic apparatus |
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| CN114518466A (en) | 2022-05-20 |
| CN109406799B (en) | 2022-03-04 |
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