CN108469529A - POCT Full-automatic chemiluminescence immunoassay analysis meters - Google Patents
POCT Full-automatic chemiluminescence immunoassay analysis meters Download PDFInfo
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- CN108469529A CN108469529A CN201810569294.8A CN201810569294A CN108469529A CN 108469529 A CN108469529 A CN 108469529A CN 201810569294 A CN201810569294 A CN 201810569294A CN 108469529 A CN108469529 A CN 108469529A
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- 238000012123 point-of-care testing Methods 0.000 title claims abstract description 28
- 238000004458 analytical method Methods 0.000 title claims abstract description 26
- 238000003018 immunoassay Methods 0.000 title claims abstract description 26
- 238000006243 chemical reaction Methods 0.000 claims abstract description 182
- 230000007246 mechanism Effects 0.000 claims abstract description 141
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 90
- 238000004140 cleaning Methods 0.000 claims abstract description 33
- 238000005070 sampling Methods 0.000 claims description 62
- 238000002156 mixing Methods 0.000 claims description 32
- 239000011324 bead Substances 0.000 claims description 20
- 238000010521 absorption reaction Methods 0.000 claims description 9
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 8
- 230000033001 locomotion Effects 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 5
- 239000012459 cleaning agent Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000005286 illumination Methods 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 abstract description 12
- 239000007788 liquid Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 9
- 239000002699 waste material Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
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- 230000001360 synchronised effect Effects 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00435—Refrigerated reagent storage
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- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The present invention discloses a kind of POCT Full-automatic chemiluminescence immunoassay analysis meters, including rack, reaction mechanism, wiper mechanism and the reagent sample mechanism being oppositely arranged with the reaction mechanism, the reaction mechanism may be contained with reagent sample mechanism in the rack, the reaction mechanism is hollow structure, the wiper mechanism is set in the hollow structure of the reaction mechanism, for cleaning the reaction cup in the reaction mechanism.Wiper mechanism is arranged in reaction tray by the way that reaction tray is set as hollow structure for technical solution of the present invention.Cleaning operation can be completed in reaction mechanism to realize, to achieve the purpose that reduce equipment volume, meet current clinical trial demand.Reaction cup is transmitted in optical de-tection means again after cleaning and is detected.
Description
Technical field
The present invention relates to biochemical fields, more particularly to POCT Full-automatic chemiluminescence immunoassay analysis meters.
Background technology
As people are for the pay attention to day by day of health, clinical testing techniques also enter the epoch of a high speed development, and
The important a member of Chemiluminescence Apparatus as clinical examination mechanism, substantially belongs to standard configuration now.On the one hand due to its test event
Diversity, inspection, the screening of various diseases, while the accurately measurement attribute of Chemiluminescence Apparatus can be competent at, clinic can be examined
It is disconnected to provide accurate basis for estimation.
POCT Full-automatic chemiluminescence immunoassay analysis meters in the prior art, generally bulky, flexibility is low, for one
A little limited section office in space, cannot be satisfied its use demand, severely impact the promptness of test, it is possible to be generated to clinic
Some negative impacts.
Invention content
The main object of the present invention is to propose a kind of POCT Full-automatic chemiluminescence immunoassay analysis meters, it is intended to solve existing skill
POCT Full-automatic chemiluminescence immunoassay analysis meters are bulky in art, and flexibility is low, the slow problem of test speed.
To achieve the above object, POCT Full-automatic chemiluminescence immunoassay analysis meters proposed by the present invention, including：It is rack, anti-
Answer mechanism, wiper mechanism and the reagent sample mechanism being oppositely arranged with the reaction mechanism, the reaction mechanism and the reagent
Sample mechanism may be contained in the rack, and the reaction mechanism is hollow structure, and the wiper mechanism is set to the reaction
In the hollow structure of mechanism, for cleaning the reaction cup in the reaction mechanism.
Preferably, the reaction mechanism include for placing response cup reaction tray, connect with the reaction tray first
Actuator, the reaction tray are rotatably dispose in the rack, and first actuator drives the reaction tray rotation so that institute
It states reaction cup and turns to corresponding sample-adding position.
Preferably, the reaction mechanism further includes the first mixing part for mixing reaction cup, and the reaction tray is equipped with
Opening, the first mixing part is arranged at the opening, when the reaction cup is turned to the opening by the reaction tray
The reaction cup is set to be abutted with the first mixing part.
Preferably, the wiper mechanism include lifters, third actuator, the rotating disc for placing the reaction cup,
Outlet pipe for injecting cleaning agent and the drainpipe for draining, the rotating disc are set to the hollow structure of the reaction tray
In, the third actuator drives the turn disc so that the reaction cup turns to cleaning position, the outlet pipe and institute
It states drainpipe to be set to above the cleaning position, and connects the lifters, the rotating disc is hollow structure, the lifters
It is set in the hollow structure of the rotating disc, the lifters make the outlet pipe be stretched into the drainpipe when falling described
In reaction cup, and the drainpipe and the bottom wall of the reaction cup abut against.
Preferably, the wiper mechanism further includes magnetic absorption member, the magnetic absorption member be set to the corresponding outlet pipe with it is described
On rotating disc below drainpipe.
Preferably, the wiper mechanism further includes the second mixing part, and the second mixing part is set on the rotating disc,
The reaction cup is turned to and is abutted with the second mixing part by the rotating disc.
Preferably, reagent sample mechanism includes reagent sample disk and the second driving being connect with the reagent sample disk
Part, the reagent sample disk are rotatably dispose in the rack, second actuator drive the reagent sample disk rotation with
The Reagent Tube and the sample tube is set to turn to sampling position.
Preferably, reagent sample mechanism further includes shell, and the reagent sample disk is set in the shell, described
Reagent Tube is equipped at least two mutually independent accommodating cavities, and the inner walls are equipped with internal tooth, on the outermost side described
Accommodating cavity bottom is equipped with gear, and when reagent sample disk rotation, the gear was located at outermost with the interior tooth engagement to drive
The accommodating cavity rotation.
Preferably, the POCT Full-automatic chemiluminescence immunoassay analysis meters further include sampling mechanism, described using mechanism packet
Include pedestal and sampling needle, the sampling needle and the removable connection of the pedestal, when the sampling needle is moved along the pedestal by
The sampling position is moved to the sample-adding position, and the sample in the sample tube and the reagent in the Reagent Tube are added with magnetic bead
Enter into the reaction cup.
Preferably, the sampling mechanism further includes the cleaning component for cleaning the sampling needle, and the cleaning component is set
It is placed on the motion track of the sampling needle.
Wiper mechanism is arranged in reaction mechanism by the way that reaction mechanism is set as hollow structure for technical solution of the present invention
In hollow structure.Sampling mechanism is moved to sampling position, while reagent sample mechanism is by the Reagent Tube and sample in reagent sample disk
Pipe turns at position corresponding with the sampling position, and sampling mechanism extend into Reagent Tube and sample tube from the sampling position and draws sample
Originally, reagent and magnetic bead；At this point, reaction tray turns to empty reaction cup at position corresponding with position is loaded, sampling mechanism is from institute
It states sampling position and is moved to sample-adding position, and sample, reagent are put into magnetic bead in the reaction cup of the sky and reacted.It is anti-after reaction
Cup is answered to be transferred on wiper mechanism, which is rotatably set in the hollow structure of the reaction tray, the cleaning machine
Structure includes multigroup outlet pipe and drainpipe for repeatedly being cleaned to the magnetic bead in reaction cup, and reaction cup is realized by rotating disc
Cleaning operation can be completed to realize, to reach in transmission between multigroup outlet pipe and drainpipe in reaction mechanism
The purpose for reducing equipment volume, meets current clinical trial demand.Reaction cup is transmitted to optical de-tection means again after cleaning
On be detected.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
The structure shown according to these attached drawings obtains other attached drawings.
Fig. 1 is the concrete structure schematic diagram of POCT Full-automatic chemiluminescence immunoassay analysis meters of the present invention；
Fig. 2 is the concrete structure schematic diagram of reaction mechanism of the present invention；
Fig. 3 is the concrete structure schematic diagram of wiper mechanism of the present invention；
Fig. 4 is the enlarged structure schematic diagram at A in Fig. 3；
Fig. 5 is the concrete structure schematic diagram of reagent sample of the present invention mechanism；
Fig. 6 is the concrete structure schematic diagram of sampling mechanism of the present invention；
Fig. 7 is the concrete structure schematic diagram of grasping mechanism of the present invention；
Fig. 8 is the concrete structure schematic diagram of recovering mechanism of the present invention；
Fig. 9 is external structure schematic diagram of the present invention.
Drawing reference numeral explanation：
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art obtained without creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
If it is to be appreciated that related in the embodiment of the present invention directionality instruction (such as up, down, left, right, before and after ...),
Then directionality instruction be only used for explaining relative position relation under a certain particular pose (as shown in the picture) between each component,
Motion conditions etc., if the particular pose changes, directionality instruction also correspondingly changes correspondingly.
If in addition, relating to the description of " first ", " second " etc. in the embodiment of the present invention, it is somebody's turn to do " first ", " second " etc.
Description be used for description purposes only, be not understood to indicate or imply its relative importance or implicitly indicate indicated skill
The quantity of art feature." first " is defined as a result, the feature of " second " can explicitly or implicitly include at least one spy
Sign.In addition, the technical solution between each embodiment can be combined with each other, but must be with those of ordinary skill in the art's energy
It is enough realize based on, when the knot that conflicting or cannot achieve when will be understood that this technical solution occurs in the combination of technical solution
Conjunction is not present, also not the present invention claims protection domain within.
The present invention proposes a kind of POCT Full-automatic chemiluminescence immunoassay analysis meters, please refers to Fig. 1, and the POCT is full-automatic
Learning luminescence immunoassay instrument includes：
Reaction mechanism 20, reaction mechanism 20 are mainly used for providing a reacting environment, but sample and examination for sample and reagent
Agent needs certain temperature that can react, and in practice, temperature is usually 37 degree or so.It therefore can be in reaction machine
Heating component is arranged to be internally heated to reaction mechanism 20 in the bottom of structure 20, and temperature is improved to be reacted with reagent for sample
Condition.At the same time it can also stick heat-preservation cotton outside reaction mechanism 20 to improve the stability of 20 internal temperature of reaction mechanism.Into
One step, the temperature inside reaction mechanism 20 can also in real time be monitored using temperature sensor, when in reaction mechanism 20
When the temperature in portion is less than preset value, then heating component is automatically opened, when the temperature inside reaction mechanism 20 is higher than preset value, then
Heating component is automatically shut down, is recycled by shaking, to be to reach metastable preset temperature inside reaction mechanism 20；
Wiper mechanism 30, wiper mechanism 30 are mainly used for carrying out Beads enrichment to 22 solution of reaction cup after reaction.It is described
Wiper mechanism 30 is set in the hollow body of the reaction mechanism 20, respective relatively independent rotation, non-interference, to reach
To the mesh for reducing equipment volume from plane space；
Reagent sample mechanism 40, reagent sample mechanism 40 is mainly used for storing Reagent Tube 42 and sample tube 43, in practical fortune
In, in order to ensure that the reagent in reagent sample mechanism 40 is not contaminated with sample, reagent sample mechanism 40 is usually made to be in base
The state of this sealing, and stablized relatively with ensureing that the temperature inside reagent sample mechanism 40 is in one in external paste heat-preserving cotton
State.It further, can also be contaminated general to reduce its by reduction temperature to reduce the activity of sample and reagent
Cooling assembly can also be arranged in the bottom of reagent sample mechanism 40 in rate, which includes but not limited to semiconductor refrigerating
Piece.The one side of semiconductor chilling plate refrigeration is close to reagent sample mechanism 40 bottom, to reduce inside reagent sample mechanism 40
Temperature, and generate heat one side connect by heat-conducting cream with cooling fin, by air-cooled mode come implement heat dissipation, in time system
Cold generated heat dissipation is to device external.Further, reagent sample machine can also be monitored at any time using temperature control system
Temperature inside structure 40, to make the temperature in the reagent sample mechanism 40 be controlled effectively.When detecting reagent sample
When 40 internal temperature of mechanism is higher than preset value, then temperature control system, which automatically opens cooling piece power supply, makes work, until temperature is reduced to
After range in preset value, cooling piece is stopped.To achieve the purpose that control 40 internal temperature of reagent sample mechanism；
Rack 10 is mainly used for supporting all parts on POCT Full-automatic chemiluminescence immunoassay analysis meters；The reagent sample
Mechanism 40 is oppositely arranged on the reaction mechanism 20 in the rack 10, and the reaction mechanism 20 is hollow structure, described
Wiper mechanism 30 is set in the hollow structure of the reaction mechanism 20, for cleaning the reaction cup in the reaction mechanism 20
22。
Specifically, the POCT Full-automatic chemiluminescence immunoassay analysis meters further include grasping mechanism 70, the grasping mechanism
70 be set in the rack 10 with by the crawl of reaction cup 22 on the reaction mechanism 20 on the wiper mechanism 30 or will
In the crawl to the optical de-tection means 60 of reaction cup 22 after reaction.Grasping mechanism 70 is mainly used for crawl and transfer reaction cup
22.The grasping mechanism 70 can vertical up-or-down movement, which declines to capture reaction cup 22, and reaction cup 22 is carried
It rises；The grasping mechanism 70 can be moved left and right laterally to be driven the reaction cup 22 between all parts；Step can be passed through among the above
Stepper motor but stepper motor is not limited to realize that grasping mechanism 70 perpendicularly or transversely moves, utilize guidance set positioning transmission side
Initial bit is defined to, position sensor.The grasping mechanism 70 further include for by reaction cup clamp folder cup assembly,
The motion is controlled by rotating stepper motor, and under natural conditions, two intermediate plates are separated to both sides under the action of the spring, when need
When clamping, motor drives two intermediate plates to move inward, compressed spring, while two panels clip forms cup outer wall and squeezes,
In the case of certain pressure, the frictional force support clip cup assembly between clip and cup picks up reaction cup and is transferred to target position
It sets, reaction cup is fallen in target location after motor rotation is unclamped, and folder cup assembly leaves, and so far reaction cup transfer action is completed.
Specifically, the POCT Full-automatic chemiluminescence immunoassay analysis meters further include optical de-tection means 60 and recovering mechanism
80, the recovering mechanism 80 includes upper cup position 81, check bit 82, waste discharge liquid level 83, loses cup position 84 and for placing response cup
Recovering tray, the recovering tray receive reaction cup 22 to be detected, the optical de-tection means 60 when turning to the upper cup position 81
Be set to makes the reaction cup 22 described with 82 corresponding position of the check bit, the recovering tray when turning to the check bit 82
Optical de-tection means 60 detect, and the recovering tray makes 22 drain of the reaction cup when turning to the waste discharge liquid level 83, described time
Closing quotation, which turns to described lose, is made the reaction cup 22 lose recycling when position 84.In practice, because light can be to optics
The measuring accuracy of testing agency 60 generates certain influence, it is therefore desirable to which optical de-tection means 60 and recovering mechanism are arranged in rack
Inside 10, it is detected with being guaranteed at dark space.Optical de-tection means 60 are mainly used for acquiring optical signalling, simultaneously to reaction
Luminous substrate is added in reaction cup after the completion of cleaning, reaction cup 22 is moved to by the upper of recovering mechanism 80 by grasping mechanism 70
To prepare to detect at cup position 81, recovering tray rotates so that reaction cup 22 turns to check bit 82 from upper cup position 81 is detected, and examines
Recovering tray is rotated again so that reaction cup 22 turns to waste discharge liquid level 83 from check bit 82, by the waste liquid pumping in cup after survey
From recovering tray is rotated again so that reaction cup 22 is turned to from waste discharge liquid level 83 loses cup position 84 after removal waste fluid, and by cup
It loses from window.Recovering tray rotates back into the waiting of cup position 81 and scoops out next reaction cup 22 again, so recycles.
The setting of wiper mechanism 30 is being reacted machine by technical solution of the present invention by the way that reaction mechanism 20 is set as hollow structure
In the hollow structure of structure 20.Sample in candidate agent sample mechanism 40, which is added to reagent in reaction cup 22, to react.It is anti-after reaction
It answers cup 22 to be crawled mechanism 70 to be transferred on wiper mechanism 30, which is rotatably set to the reaction mechanism 20
In hollow structure, cleaning operation can be completed in reaction mechanism 20 to realize, to achieve the purpose that reduce equipment volume,
Meet current clinical trial demand.Reaction cup 22 is transmitted in optical de-tection means 60 again after cleaning and is detected.
Specifically, the reaction mechanism 20 includes connecting for the reaction tray 21 of placing response cup 22, with the reaction tray 21
The first actuator connect, the reaction tray 21 are rotatably dispose in the rack 10, and first actuator drives the reaction
Disk 21 rotates so that the reaction cup 22 turns to corresponding sample-adding position 23.It is equipped in reaction tray 21 several described for placing
The storage tank of reaction cup 22, the storage tank are distributed on the inner ring and outer ring of reaction tray 21, are arranged side by side to increase reaction
The carrying quantity of cup 22, can accommodate more reaction cups and be reacted, to improve the detection efficiency of equipment.It can manage
Solution, reaction tray 21 can be by way of stepper motors and synchronous belt cooperation, so that reaction tray 21 rotates, to ensure each reaction
On the sample-adding rail position that cup can be run to.Become in 21 outside one code-disc of setting stroke low and high level after sensor of reaction tray
Change, so as to position distance of each reaction cup 22 by sample-adding position 23, to enable reaction cup 22 to rest on sample-adding position
It sentences and is loaded.
Specifically, the wiper mechanism 30 includes lifters 32, third actuator, for placing turning for the reaction cup 22
Moving plate 31, the outlet pipe 33 for injecting cleaning agent and the drainpipe 34 for draining, the rotating disc 31 are set to described anti-
It should coil in 21 hollow structure, the third actuator drives the rotation of rotating disc 31 so that the reaction cup 22 turns to clearly
Position is washed, the outlet pipe 33 is set to the drainpipe 34 above the cleaning position, and connects the lifters 32, described turn
Moving plate 31 is hollow structure, and the lifters 32 are set in the hollow structure of the rotating disc 31, and the lifters 32 are fallen
When so that the outlet pipe 33 and 34 pipes of the draining is stretched into the reaction cup 22, and the drainpipe 34 and the reaction cup 22
Bottom wall abut against.Be again provided with multiple storage tanks for placing response cup 22 on rotating disc 31, the rotation of rotating disc 31 with
Reaction cup 22 is set to turn to the lower section of outlet pipe 33 and drainpipe 34, lifters 32 and rotating disc 31 are relatively independent, therefore are turning
When Moving plate 31 rotates, lifters 32 will not be with turn disc, i.e. outlet pipe 33 and the relative rotation disk 31 of drainpipe 34 is static,
To make each reaction cup 22 that can be cleaned by outlet pipe 33 and 34 lower section of drainpipe.Lifters 32 decline to use
Water pipe 33 is extend into drainpipe 34 in reaction cup, and cleaning agent is added into reaction cup 22 and is cleaned for outlet pipe 33, drainpipe
34 opposite outlet pipes 33 are longer, because drainpipe 34 needs the waste liquid after cleaning all to be sucked out, drainpipe 34 needs
Abutted with 22 bottom of reaction cup with ensure waste liquid all be sucked out, while 34 bottom of drain pipe be equipped with notch, with prevent nozzle by
It is dead to block.It is appreciated that wiper mechanism 30 may include multigroup outlet pipe 33 and drainpipe 34, to be carried out repeatedly to reaction cup 22
Cleaning is to ensure to clean up.
Specifically, the wiper mechanism 30 further includes magnetic absorption member, the magnetic absorption member be set to the corresponding outlet pipe 33 with
On the rotating disc 31 of 34 lower section of the drainpipe.Because containing in practice in reaction, there are many magnetic beads, by being set on rotating disc 31
The magnetic absorption member for setting a certain strength, to ensure that magnetic bead can effectively be stayed in reaction cup 22 in drain, and it is other useless
Liquid is then discharged.
Specifically, reagent sample mechanism 40 include reagent sample disk 41 and connect with the reagent sample disk second
Actuator, the reagent sample disk 41 are rotatably dispose in the rack 10, and second actuator drives the reagent sample
Disk 41 rotates so that the Reagent Tube 42 and the sample tube 43 turn to sampling position 44.Reagent Tube 42 on reagent sample disk 41
Put by the way of circumference array, Reagent Tube 42 gap location be sample tube 43 placement location, each Reagent Tube 42 with
One sample tube 43 corresponds to, and to which sampling mechanism once can be sampled all, without repeatedly being cleaned, improves efficiency.
Specifically, the POCT Full-automatic chemiluminescence immunoassay analysis meters further include sampling mechanism 50, the sampling mechanism
50 include pedestal and sampling needle 51, and the sampling needle 51 moves connection with the pedestal, and the sampling needle 51 is along the bottom
The sample-adding position 23 is moved to by the sampling position 44 when seat is mobile, by the sample tube 43 sample and the Reagent Tube
Reagent in 42 is added to magnetic bead in the reaction cup 22.The sampling needle 51 has liquid level detection function, when the sampling needle
51 during the decline, and when needle point touches liquid level, the capacitance of the sampling needle can then change, and then be given on circuit
Go out to judge signal, judge that signal judges that sampling needle 51 reaches liquid level according to this, is done further according to actual needs next other dynamic
Make sequential.
Further, the sampling needle 51 has collision prevention function, and the top of sampling needle 51 is provided with anticollision mechanism.This is anti-
The structure that collides includes the elastic component being arranged at 51 top of the sampling needle, is pushed down sampling needle 51 by elastic component under normal condition, when
Sampling needle 51 occurs in the case of bottoming out or colliding, and sampling needle 51 offsets collision by squeezing the elastic component, meanwhile, the anticollision
Mechanism further includes the optocoupler and light barrier being arranged in 51 upper end of sampling needle, when sampling needle 51 squeezes elastic component, the light barrier
It is detached from optocoupler, so that optocoupler changes circuit signal, continues to decline to control stopping sampling needle 51, prevents fragility
Sampling needle 51 is damaged, it is often more important that, when there is difficult to handle phenomenon, sampling needle 51 also can timely stop motion, with
Anti- further injury causes.
As a kind of embodiment, detection process is：Sampling mechanism 50 is moved to sampling position 44, while reagent sample mechanism
40 by reagent sample disk 41 Reagent Tube 42 and sample tube 43 turn at position corresponding with the sampling position 44, sampling mechanism
50 extend into Reagent Tube 42 from the sampling position 44 and draw sample, reagent and magnetic bead in sample tube 43；At this point, reaction tray 21 will be empty
Reaction cup 22 turn to at the corresponding position in sample-adding position 23, sampling mechanism 50 is moved to from the sampling position 44 and is loaded position
23, and sample, reagent are put into magnetic bead in the reaction cup 22 of the sky and reacted.It will reaction by the first mixing mechanism 24
Reagent and sample mixing in cup wait for sample and reagent after the completion of mixing quietly and are carried out in the reaction tray 21 of 37 ° and opposing seal
Incubation reaction.Reaction cup 22 is crawled mechanism 70 and is transferred on wiper mechanism 30 after reaction, which is rotatably arranged
In the hollow structure of the reaction tray 21, which includes multigroup outlet pipe 33 and drainpipe 34 for repeatedly to anti-
The magnetic bead in cup 22 is answered to be cleaned, magnetic bead is tightly adsorbed on wall of cup by the way that the magnetic absorption member on rotating disc 31 is arranged, to
Will not reaction cup 22 be discharged by drainpipe 34, by rotating disc 31 realize reaction cup 22 multigroup outlet pipe 33 and drainpipe 34 it
Between transmission, to realize cleaning operation can be completed in reaction mechanism 20, to achieve the purpose that reduce equipment volume, symbol
Clinical trial demand before being fated.Reaction cup 22 is transmitted by grasping mechanism 70 in reaction tray 21 again after cleaning, passes through sampling
Needle 51 is added in reaction cup 22 from taking out quantitative substrate solution in substrate bottle, and by 24 mixing of the first mixing part, then by
Grasping mechanism 70 grabs cup position 81, is detected by optical de-tection means 60.The acquisition reaction of optical de-tection means 60
Photooptical data in cup 22, that is, with substrate solution photon numbers-light intensity caused by chemical reaction occurs for target substance, leads to
The light intensity measured is crossed, specific calculation formula is re-incorporated into, you can converses the concentration value of the measurement object.Pass through recycling machine later
Structure 80 recycles reaction cup 22.
Specifically, the reaction mechanism 20 further includes the first mixing part 24 for mixing reaction cup 22, the reaction tray
21 are equipped with opening, and the first mixing part 24 is arranged at the opening, and the reaction tray 21 rotates the reaction cup 22
The reaction cup 22 is set to be abutted with the first mixing part 24 when to the opening.The opening makes the reaction by the position
Outside cup 22 is partially exposed at, when reaction tray 21 rotates, the reaction cup 22 for turning to the position is then abutted with the first mixing part 24, the
One mixing part 24 shakes, and is reacted to make sample, reagent in reaction cup 22 be mixed well with magnetic bead.It is appreciated that reaction tray
21 in inner ring, outer ring sample-adding position respectively there are one the first mixing part 24, to ensure the sample in reaction cup 22 all in reaction tray 21
Originally, reagent is mixed well with magnetic bead and is reacted.
Specifically, the wiper mechanism 30 further includes the second mixing part 35, the second mixing part 35 is set to described turn
On Moving plate 31, the reaction cup 22 is turned to and is abutted with the second mixing part 35 by the rotating disc 31.Pass through the second mixing
Part 35 carries out mixing to magnetic bead, reduce because caking, dead angle and caused by the halfway problem of cleaning.
Specifically, reagent sample mechanism 40 further includes shell, the reagent sample disk 41 is set in the shell,
The Reagent Tube 42 is equipped at least two mutually independent accommodating cavities, and the inner walls are equipped with internal tooth, are located at outermost
The accommodating cavity bottom be equipped with gear, the reagent sample disk 41 when rotating the gear with the interior tooth engagement to drive position
It is rotated in the outermost accommodating cavity.In practice, the different types of required reagent type of detection is different, usually
It is set on each Reagent Tube 42 there are four independent cavity, is needed that more or less independent chambers can also be arranged according to detection
Body.The cavity stores the different reagent components corresponding to each detection project respectively, wherein outermost cavity is for loading
Magnetic bead is in cylinder, and bottom belt has gear, is meshed with shell internal gear by gear, should when reagent sample disk 41 rotates
Cavity can rotate relatively freely, to carry out mixing to the magnetic bead solution in reagent bottle, to prevent magnetic bead from settling.
Specifically, the sampling mechanism 50 further includes the cleaning component 52 for cleaning the sampling needle, the cleaning part
Part is set on the motion track of the sampling needle 51.When sampling needle 51 by reagent, sample and magnetic bead be put into reaction cup 22 it
Afterwards, it is moved at 52 position of cleaning component and is cleaned, to sample and reagent when preventing sampling needle 51 from acquire next time
Etc. polluting.
Specifically, the sampling needle 51 is reducing needle tubing, to which the volume ensured in needle is beaten enough, make the sample of quantitative absorption
This or reagent do not exceed needle tubing and enter to be difficult to clean thoroughly in pipeline or connector, and then avoid the occurrence of cross contamination.
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of the invention, every at this
Under the inventive concept of invention, using equivalent structure transformation made by description of the invention and accompanying drawing content, or directly/use indirectly
In the scope of patent protection that other related technical areas are included in the present invention.
Claims (10)
1. a kind of POCT Full-automatic chemiluminescence immunoassay analysis meters, which is characterized in that the POCT Full-automatic chemiluminescences are immune
Analyzer includes：Rack, reaction mechanism, wiper mechanism and the reagent sample mechanism being oppositely arranged with the reaction mechanism, it is described
Reaction mechanism may be contained with reagent sample mechanism in the rack, and the reaction mechanism is hollow structure, the cleaning
Mechanism is set in the hollow structure of the reaction mechanism, for cleaning the reaction cup in the reaction mechanism.
2. POCT Full-automatic chemiluminescence immunoassay analysis meters as described in claim 1, which is characterized in that the reaction mechanism packet
The first actuator for including the reaction tray for placing response cup, being connect with the reaction tray, the reaction tray are rotatably dispose in institute
It states in rack, first actuator drives the reaction tray rotation so that the reaction cup turns to corresponding sample-adding position.
3. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 2, which is characterized in that the reaction mechanism is also
Include the first mixing part for mixing reaction cup, the reaction tray is equipped with opening, and the first mixing part is set to described
Opening, the reaction tray make the reaction cup be supported with the first mixing part when the reaction cup is turned to the opening
It connects.
4. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 2, which is characterized in that the wiper mechanism packet
Include lifters, third actuator, the rotating disc for placing the reaction cup, the outlet pipe for injecting cleaning agent and for arranging
The drainpipe of water, the rotating disc are set in the hollow structure of the reaction tray, and the third actuator drives the rotation
Disk rotates so that the reaction cup turns to cleaning position, and the outlet pipe is set to the drainpipe above the cleaning position,
And the lifters are connected, the rotating disc is hollow structure, and the lifters are set in the hollow structure of the rotating disc,
The lifters make the outlet pipe and the drainpipe stretch into the reaction cup when falling, and the drainpipe with it is described anti-
The bottom wall of cup is answered to abut against.
5. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 4, which is characterized in that the wiper mechanism is also
Including magnetic absorption member, the magnetic absorption member is set on the rotating disc below the corresponding outlet pipe and the drainpipe.
6. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 4, which is characterized in that the wiper mechanism is also
Including the second mixing part, the second mixing part is set on the rotating disc, and the rotating disc turns to the reaction cup
It is abutted with the second mixing part.
7. POCT Full-automatic chemiluminescence immunoassay analysis meters as described in claim 1, which is characterized in that the reagent sample machine
Structure includes reagent sample disk and the second actuator for being connect with the reagent sample disk, and the reagent sample disk is rotatably dispose in institute
It states in rack, second actuator drives the reagent sample disk rotation so that the Reagent Tube and the sample tube turn to
Sample position.
8. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 7, which is characterized in that the reagent sample machine
Structure further includes shell, and the reagent sample disk is set in the shell, and the Reagent Tube is equipped at least two independently of each other
Accommodating cavity, the inner walls be equipped with internal tooth, the accommodating cavity bottom on the outermost side be equipped with gear, the reagent sample
The gear drives the accommodating cavity on the outermost side to rotate with the interior tooth engagement when rotation of this disk.
9. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 8, which is characterized in that the POCT is full-automatic
Chemical illumination immunity analysis instrument further includes sampling mechanism, and described using mechanism includes pedestal and sampling needle, the sampling needle with
The removable connection of the pedestal, the sample-adding position is moved to when the sampling needle is moved along the pedestal by the sampling position, with
Sample in the sample tube and the reagent in the Reagent Tube are added to magnetic bead in the reaction cup.
10. POCT Full-automatic chemiluminescence immunoassay analysis meters as claimed in claim 9, which is characterized in that the sampling mechanism
Further include the cleaning component for cleaning the sampling needle, the cleaning component is set on the motion track of the sampling needle.
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| CN201810569294.8A CN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
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| CN201810569294.8A CN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
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| CN108469529B CN108469529B (en) | 2024-09-13 |
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| CN201810569294.8A Active CN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
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| CN109358201A (en) * | 2018-10-16 | 2019-02-19 | 基蛋生物科技股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN110501513A (en) * | 2019-09-19 | 2019-11-26 | 南京迪格诺斯生物技术有限公司 | A kind of chemiluminescent analyzer |
| CN110514858A (en) * | 2019-08-21 | 2019-11-29 | 成都斯马特科技有限公司 | A kind of automatic chemiluminescence immunoassay reagent bag apparatus |
| WO2020078021A1 (en) * | 2018-10-16 | 2020-04-23 | 基蛋生物科技股份有限公司 | Reaction plate and system |
| CN111257556A (en) * | 2018-11-30 | 2020-06-09 | 深圳市帝迈生物技术有限公司 | Immunoassay analyzer and sample analysis method |
| CN112858709A (en) * | 2021-01-18 | 2021-05-28 | 桂林优利特医疗电子有限公司 | Gripping and sucking integrated mechanism of chemiluminescence immunoassay analyzer and use method |
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| CN113376391A (en) * | 2021-07-09 | 2021-09-10 | 广州蓝勃生物科技有限公司 | Get liquid device and full-automatic immunoassay appearance |
| CN114001997A (en) * | 2021-10-22 | 2022-02-01 | 广州检验检测认证集团有限公司 | Sampling cleaning device for formaldehyde test |
| CN114152477A (en) * | 2021-11-26 | 2022-03-08 | 上海品峰医疗科技有限公司 | Anti-collision protection method for vacuum blood collection tube puncture sampling needle |
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