CN110514858A - A kind of automatic chemiluminescence immunoassay reagent bag apparatus - Google Patents
A kind of automatic chemiluminescence immunoassay reagent bag apparatus Download PDFInfo
- Publication number
- CN110514858A CN110514858A CN201910773576.4A CN201910773576A CN110514858A CN 110514858 A CN110514858 A CN 110514858A CN 201910773576 A CN201910773576 A CN 201910773576A CN 110514858 A CN110514858 A CN 110514858A
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- reagent
- cup
- chamber
- bag apparatus
- turntable
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 346
- 238000003018 immunoassay Methods 0.000 title claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims abstract description 10
- 238000003825 pressing Methods 0.000 claims abstract description 9
- 239000012528 membrane Substances 0.000 claims description 21
- 238000001514 detection method Methods 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 230000009471 action Effects 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- 238000007664 blowing Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000002699 waste material Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- -1 antibody Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002038 chemiluminescence detection Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000010068 moulding (rubber) Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229910021655 trace metal ion Inorganic materials 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1039—Micropipettes, e.g. microcapillary tubes
Abstract
The invention discloses a kind of automatic chemiluminescence immunoassay reagent bag apparatus, including reagent cup, reagent cup turntable and reagent pressing mechanism, multiple reagent chambers are separated into inside reagent cup, multiple reagent exit pipes are provided in the exterior circumference of reagent cup, a reagent exit pipe is arranged in one reagent chamber, reagent exit pipe is connected to reagent chamber, reagent cup turntable is connected in reagent cup, multiple through-holes and a driving groove are provided on reagent rotor, the quantity of through-hole is identical as reagent chamber, each through-hole is connected to a reagent chamber respectively, driving groove is socketed on the output shaft of motor, motor drives the rotation of reagent cup turntable.The present invention replaces artificial absorption reagent, improves reagent extraction efficiency, keeps reagent pack arrangement more compact, can be applied to automatic chemiluminescence immunoassay device.
Description
Technical field
The present invention relates to a kind of biochemical analyser more particularly to a kind of instrument that immunoassay is carried out using chemoluminescence method
Device.
Background technique
Chemoluminescence method (ChemiLuminescence, referred to as CL) is one kind in mulecular luminescence spectra methods,
It is mainly linearly fixed under certain condition according to testing concentration in chemical detection system and the chemiluminescence intensity of system
The principle of magnitude relation, the detection using instrument to system chemiluminescence intensity, and determine a kind of trace analysis of determinand content
Method.Chemoluminescence method has extensively in trace metal ion, all kinds of inorganic compounds, Organic compound analysis and biological field
Application.
Chemiluminescence immunoassay detects (chemiluminescence immunoassay, CLIA), is will have high sensitivity
Chemical luminescent detecting technology combined with the immune response of high specific, be used for various antigens, antibody, hormone, enzyme, vitamin
With the detection and analysis technology of drug etc..It is to exempt from analysis, fluoroimmunoassay and time-resolved fluoroimmunoassay point after radioimmunology analysis, enzyme
The immunoassay to grow up after analysis.Chemoluminescence method has high sensitivity, and high specificity, accuracy is high, inspection
Survey the advantages that range is wide.Relative to the sxemiquantitative of Enzyme-Linked Immunospot, chemiluminescence is really quantitative, and detect speed compared with
Fastly, more convenient.Meanwhile chemiluminescent labels are stablized, reagent validity period is long, greatly facilitates the needs of clinical application.
When carrying out chemiluminescence detection, reagent is essential substance (such as cleaning solution, reactant, luminous substrate
Deng), when what reagent when existing operation need, operator draws reagent with suction tool and is injected into capillary, such behaviour
Making existing greatest drawback is exactly to need repeatedly to draw, and operating efficiency is low, needs manually ceaselessly to draw related reagent, and labour is strong
Degree is big.It can not be suitable for automatic chemiluminescence immunoassay device.
Summary of the invention
In order to overcome mentioned reagent to draw manually, existing operating efficiency is low, and the biggish defect of labor intensity, the present invention mentions
For a kind of automatic chemiluminescence immunoassay reagent bag apparatus, artificial absorption reagent is replaced by the device, is improved
Reagent extraction efficiency, can be applied to automatic chemiluminescence immunoassay device.
In order to solve the above technical problems, the technical scheme adopted by the invention is that:
A kind of automatic chemiluminescence immunoassay reagent bag apparatus, it is characterised in that: including reagent cup, reagent cup turntable and
Reagent pressing mechanism is separated into multiple reagent chambers inside reagent cup, multiple reagent exits is provided in the exterior circumference of reagent cup
A reagent exit pipe is arranged in pipe, a reagent chamber, and reagent exit pipe is connected to reagent chamber, and reagent cup turntable is connected to reagent cup
On, rubber membrane is installed in the junction of reagent rotor and reagent cup, rubber pattern (guarantees that reagent can only be from examination for sealed reagent chamber
Agent outlet squeezes out, and cannot flow out from the other end of reagent chamber), multiple through-holes and a biography are provided on reagent rotor
Dynamic slot, the quantity of through-hole is identical as reagent chamber, and each through-hole is connected to a reagent chamber respectively, and driving groove is socketed in the defeated of motor
On shaft, motor drives the rotation of reagent cup turntable, and reagent pressing mechanism includes pressure ram and power source, pressure ram and power source
(motor, cylinder, oil cylinder, electric pushrod etc.) is connected, and under the action of power source, pressure ram protrudes into from through-hole and is extruded in rubber membrane
On, by the reagent in rubber membrane deformable squeeze reagent chamber, reagent is squeezed out from reagent exit pipe.Pressure ram promotes, and is extruded in
On rubber membrane, the reagent in reagent chamber is squeezed out by rubber membrane deformation.Due to being provided with multiple reagent chambers in reagent cup, each
A kind of reagent is stored in reagent chamber, when needing to squeeze out that reagent, the reagent chamber for having the reagent is aligned by rotary electric machine rotation
Pressure ram, then pressure ram movement can squeeze out reagent.In order to be accurately positioned whether the reagent chamber of needs is directed at pressure ram,
One sensor can be installed at pressure ram, detected whether that reagent chamber is directed at pressure ram.
For the ease of adjusting the distance between reagent bag apparatus and rotary disc assembly, it is convenient for capillary siphoning reagent, the examination
Agent bag apparatus further includes reagent mounting base, reagent line rail and reagent motor, and reagent gear, examination are socketed on the output shaft of reagent motor
Reagent rack gear is installed, reagent gear is engaged with reagent rack gear, and reagent mounting base is mounted on reagent line rail, is being tried in agent mounting base
Under the action of agent motor, slided on reagent line rail.The reagent rotor, rotary electric machine, power source are installed in reagent installation
On seat.
For the size of detection reagent drop, (the inspection of a reagent droplet size detection sensor is installed below reagent cup
Survey optocoupler), the reagent droplet size information that will test feeds back to the controller of power source, and then power source control squeezes out bar
It acts, after the reagent droplet for squeezing out suitable size, no longer squeezes.
The reagent cup is connected on reagent cup turntable by reagent cup shell, and it is convex that clamping is provided on reagent cup shell
It rises, is provided with clamping groove on reagent cup turntable, after being embedded into clamping groove by clamping protrusion, reagent cup shell is in the axial direction
Radially equal cup is fixed, and reagent cup is socketed on reagent cup shell.
Compared with prior art, the invention has the following advantages:
1, the present invention includes reagent cup, reagent cup turntable and reagent pressing mechanism, is separated into multiple reagent chambers inside reagent cup, is tried
Multiple reagent exit pipes are provided in the exterior circumference of agent cup, a reagent exit pipe, reagent exit pipe is arranged in a reagent chamber
It is connected to reagent chamber, reagent cup turntable is connected in reagent cup, installs rubber membrane, rubber in the junction of reagent rotor and reagent cup
For sealed reagent chamber, (guarantee reagent can only squeeze out rubber moulding from reagent exit pipe, and cannot be from the other end stream of reagent chamber
Out), multiple through-holes and a driving groove are provided on reagent rotor, the quantity of through-hole is identical as reagent chamber, each through-hole difference
It is connected to a reagent chamber, driving groove is socketed on the output shaft of motor, and motor drives the rotation of reagent cup turntable, reagent extruder
Structure includes pressure ram and power source, and pressure ram is connected with power source (motor, cylinder, oil cylinder, electric pushrod etc.), in power source
Under effect, pressure ram is protruded into from through-hole and is extruded on rubber membrane, by the reagent in rubber membrane deformable squeeze reagent chamber, by reagent
It is squeezed out from reagent exit pipe.Pressure ram promotes, and is extruded on rubber membrane, is deformed by rubber membrane and squeezes the reagent in reagent chamber
Out.Due to being provided with multiple reagent chambers in reagent cup, a kind of reagent is stored in each reagent chamber, when needing to squeeze out that reagent,
The reagent chamber for having the reagent is directed at pressure ram by rotary electric machine rotation, and then pressure ram movement can squeeze out reagent.For
It is accurately positioned whether the reagent chamber needed is directed at pressure ram, a sensor can be installed at pressure ram, has detected whether
Reagent chamber is directed at pressure ram.Reagent bag apparatus of the invention compared with the existing technology for, the extrusion of plurality of reagents can be provided,
Convenient for capillary siphoning.Instead of drawing reagent by hand, efficiency is significantly improved, and does not also need repeatedly to draw reagent by hand, automatically
Change operation, automatic chemiluminescence immunoassay device can be suitable for.
2, the invention also includes reagent mounting base, reagent line rail and reagent motor, examination is socketed on the output shaft of reagent motor
Agent gear installs reagent rack gear in reagent mounting base, and reagent gear is engaged with reagent rack gear, and reagent mounting base is mounted on reagent line
On rail, under the action of reagent motor, slided on reagent line rail.The reagent rotor, rotary electric machine, power source are installed in
In reagent mounting base, such reagent cup, reagent rotor, rotary electric machine, power source are as reagent mounting base is together in reagent line rail
Upper sliding.The distance between integrally-regulated reagent bag apparatus and rotary disc assembly guarantee that reagent can be siphoned into its pipe by capillary
It is interior.
3, the present invention installs a reagent droplet size detection sensor (detection optocoupler) below reagent cup, will test
Reagent droplet size information feed back to the controller of power source, then power source control squeezes out the movement of bar, squeezes out suitable big
After small reagent droplet, no longer squeeze.The amount of just suitable capillary siphoning can disposably be squeezed out in this way, reagent is seldom not
It is few, it not will cause the waste of reagent, do not need repeated processing reagent droplet yet, improve efficiency.
4, reagent cup of the present invention is connected on reagent cup turntable by reagent cup shell, and clamping is provided on reagent cup shell
Protrusion is provided with clamping groove on reagent cup turntable, and after being embedded into clamping groove by being clamped protrusion, reagent cup shell is in axial direction
Upper to fix with radially equal cup, reagent cup is socketed on reagent cup shell.Reagent cup is mounted on reagent by way of clamping
On cup turntable, it is conveniently replaceable reagent cup, loads reagent.
Detailed description of the invention
Fig. 1 is overall structure of the present invention；
Fig. 2 is another direction of visual lines structural schematic diagram of the present invention；
Fig. 3 is reagent cup structural schematic diagram of the present invention；
Fig. 4 is that reagent cup of the present invention covers rubber membrane structure diagram；
Fig. 5 is reagent cup shell mechanism schematic diagram of the present invention；
Fig. 6 is reagent cup turntable structure schematic diagram of the present invention；
Fig. 7 is the structural schematic diagram that the present invention is assembled into automatic chemiluminescence immunoassay device with other assemblies cooperation.
Appended drawing reference 1, capillary storage assembly, 2, capillary release component, 3, rotary disc assembly, 4, air blowing component,
5, sample component, 6, reagent bag apparatus, 60, reagent cup, 61, reagent cup turntable, 62, reagent pressing mechanism, 63, reagent chamber,
64, reagent exit pipe, 65, motor, 66, pressure ram, 67, power source, 68, mounting base, 69, reagent line rail, 610, reagent motor,
611, reagent gear, 612, reagent rack gear, 613, reagent cup shell, 614, droplet size detection sensor, 615, rubber membrane, 7,
Detection components, 8, bottom plate, 9, capillary.
Specific embodiment
The present invention will be further described with reference to the examples below, and described embodiment is only present invention a part
Embodiment is not whole embodiment.Based on the embodiments of the present invention, those skilled in the art are not making
Other embodiments used obtained, belong to protection scope of the present invention under the premise of creative work.Occur in the present invention
Such as " preceding ", " rear ", " left side ", " right side " only represents relative positional relationship to the noun of locality, retouches both for what the orientation of Fig. 7 carried out
It states, not necessarily actual left-right and front-back position, therefore cannot the understanding of being restricted property.
The present invention provides a kind of reagent bag apparatus, effect is that various reagents are provided for capillary, such as cleaning solution, anti-
Body, reactant, luminous substrate etc..The advantage of this reagent bag apparatus is that plurality of reagents drop can be provided, needs to use that
Reagent droplet, so that it may the corresponding reagent droplet of automatic-extrusion.
Reagent bag apparatus 6 of the invention includes reagent cup 60, reagent cup turntable 61 and reagent pressing mechanism 62, reagent cup 60
Inside is separated into multiple reagent chambers 63, and multiple reagent exit pipes 64, a reagent chamber are provided in the exterior circumference of reagent cup 60
63 are arranged a reagent exit pipe 64, and reagent exit pipe is connected to reagent chamber, and reagent cup turntable 61 is connected in reagent cup 60, In
Rubber membrane 615 is installed in their junction, by rubber diaphragm sealed reagent chamber 63, reagent chamber 63 is avoided to flow out reagent, reagent turns
Multiple through-holes and a driving groove are provided on disk 61, the quantity of through-hole is identical as reagent chamber, and each through-hole is tried with one respectively
The connection of agent chamber, driving groove are socketed on the output shaft of motor 65, and motor 65 drives reagent cup turntable 61 to rotate, reagent pressing mechanism
62 include pressure ram 66 and power source 67, pressure ram 66 and power source 67(motor, cylinder, oil cylinder, electric pushrod etc.) it is connected, In
Under the action of power source, pressure ram is protruded into from through-hole squeezes rubber membrane 615, and the reagent in rubber membrane deformable squeeze reagent chamber will
Reagent is squeezed out from reagent exit pipe.Pressure ram promotes, and is squeezed and deformed rubber membrane, and the reagent in reagent chamber is squeezed in rubber membrane deformation
Out.Due to being provided with multiple reagent chambers in reagent cup, a kind of reagent is stored in each reagent chamber, when needing to squeeze out that reagent,
The reagent chamber for having the reagent is directed at pressure ram by rotary electric machine rotation, and then pressure ram movement can squeeze out reagent.For
It is accurately positioned whether the reagent chamber needed is directed at pressure ram, a sensor can be installed at pressure ram, has detected whether
Reagent chamber is directed at pressure ram.
For the ease of adjusting the distance between reagent bag apparatus and rotary disc assembly, it is convenient for capillary siphoning reagent, the examination
Agent bag apparatus further includes reagent mounting base 68, reagent line rail 69 and reagent motor 610, is socketed on the output shaft of reagent motor 610
Reagent gear 611 installs reagent rack gear 612 in reagent mounting base 68, and reagent gear 611 is engaged with reagent rack gear 612, and reagent is pacified
Dress seat 68 is mounted on reagent line rail 69, under the action of reagent motor, is slided on reagent line rail.The reagent rotor turns
Dynamic motor, power source are installed in reagent mounting base, and such reagent cup, reagent rotor, rotary electric machine, power source are with reagent
Mounting base is slided on reagent line rail together.The distance between integrally-regulated reagent bag apparatus and rotary disc assembly guarantee capillary
Reagent can be siphoned into its pipe.
For the size of detection reagent drop, a reagent droplet size detection sensor 614 is installed below reagent cup
(detection optocoupler), the reagent droplet size information that will test feeds back to the controller of power source, and then power source control squeezes out
The movement of bar after the reagent droplet for squeezing out suitable size, no longer squeezes.
The reagent cup 60 is connected on reagent cup turntable 61 by reagent cup shell 613, is provided on reagent cup shell
Clamping is raised, is provided with clamping groove on reagent cup turntable, and after being embedded into clamping groove by clamping protrusion, reagent cup shell exists
It is fixed in axial direction with radially equal cup, reagent cup is socketed on reagent cup shell.
In order to which rotary disc assembly can accurately transport to capillary quasi- at reagent sites, a position is installed at reagent sites
Sensor, for detecting whether thering is capillary to reach at this, so that the reagent droplet of extrusion can avoid reagent by capillary siphoning
Drop squeezes out, and the non-in-position of capillary causes reagent droplet to waste.
The present invention provides a kind of automatic chemiluminescence immunoassay device, the effect of the device is to realize blood sample
All steps of chemiluminescence immune assay, whole automatic operations, user need to only load onto blood sample, starting device, i.e.,
It can automatically be detected, automatically generate testing result.The specific structure of the device:
It include: capillary storage assembly 1, capillary release component 2, rotary disc assembly 3, air blowing component 4, sample component 5, reagent packet
Device 6, detection components 7 and bottom plate 8, said modules are installed on bottom plate 8.Their relative positional relationship are as follows: capillary pushes away
Component 2 is located at the left side of capillary storage assembly 1 out, and the rotary disc assembly 3 is located at the right side of capillary storage assembly 1, described
Air blowing component 4 is located at the left side of rotary disc assembly 3, and air blowing component 4 is located at capillary storage assembly 1 and capillary releases component 2
Front side, capillary storage assembly 1 and capillary release the left side that component 2 is mounted on 3 upper portion of rotary disc assembly by mounting plate,
Air blowing component 4 is mounted on the left side of 3 lower half portion of rotary disc assembly.The sample component 5, reagent bag apparatus 6 and detection components 7 are equal
Positioned at the right side of rotary disc assembly 3, the reagent bag apparatus 6 is located at the centre of sample component 5 and detection components 7, and sample component 5
In the forward right side of rotary disc assembly, detection components are located at the rear right side of rotary disc assembly.In sample component, air blowing component and reagent packet
Waste liquid tank is provided with below device, waste liquid tank is mounted below bottom plate, waste liquid tank for collect sample component, air blowing component and
The waste liquid that reagent bag apparatus generates.
Capillary is released component 2 and is released the capillary in capillary storage assembly 1 is located at, and is sent on rotary disc assembly 3, institute
It states the rotation of rotary disc assembly 3 and capillary 9 is transported to sample component 5,7 position of air blowing component 4, reagent bag apparatus 6 and detection components
Place, the air blowing component are used to dispose the residual liquid in capillary 9, and the sample component is used to provide blood to capillary
Sample, the reagent bag apparatus are used to provide reagent to capillary, and the detection components are used to detect the luminous light of detection capillary
Subnumber.
Claims (5)
1. a kind of automatic chemiluminescence immunoassay reagent bag apparatus, it is characterised in that: including reagent cup, reagent cup turntable
With reagent pressing mechanism, multiple reagent chambers are separated into inside reagent cup, multiple reagents are provided in the exterior circumference of reagent cup and are gone out
A reagent exit pipe is arranged in mouth pipe, a reagent chamber, and reagent exit pipe is connected to reagent chamber, and reagent cup turntable is connected to reagent
On cup, reagent cup and reagent cup turntable joint are equipped with rubber membrane, and reagent chamber connects with rubber membrane, is provided on reagent rotor
Multiple through-holes and a driving groove, the quantity of through-hole is identical as reagent chamber, and each through-hole is connected to a reagent chamber respectively, transmission
Slot is socketed on the output shaft of motor, and motor drives the rotation of reagent cup turntable.
2. a kind of automatic chemiluminescence immunoassay reagent bag apparatus according to claim 1, it is characterised in that: institute
Stating reagent pressing mechanism includes pressure ram and power source, and pressure ram is connected with power source, under the action of power source, pressure ram from
Through-hole is protruded into be contacted with rubber membrane, and by squeezing the reagent in rubber membrane extruding reagent chamber, reagent is squeezed out from reagent exit pipe.
3. a kind of automatic chemiluminescence immunoassay reagent bag apparatus according to claim 1, it is characterised in that: institute
Stating reagent bag apparatus further includes reagent mounting base, reagent line rail and reagent motor, is socketed reagent tooth on the output shaft of reagent motor
It takes turns, reagent rack gear is installed in reagent mounting base, reagent gear is engaged with reagent rack gear, and reagent mounting base is mounted on reagent line rail
On, under the action of reagent motor, slided on reagent line rail, the reagent rotor, rotary electric machine, power source are installed in examination
In agent mounting base.
4. a kind of automatic chemiluminescence immunoassay reagent bag apparatus according to claim 1, it is characterised in that: institute
It states and reagent droplet size detection sensor is installed below reagent cup, the reagent droplet size information that will test feeds back to power
The controller in source, then power source control squeezes out the movement of bar, after the reagent droplet for squeezing out suitable size, no longer squeezes.
5. a kind of automatic chemiluminescence immunoassay reagent bag apparatus according to claim 1, it is characterised in that: institute
It states reagent cup to be connected on reagent cup turntable by reagent cup shell, clamping protrusion is provided on reagent cup shell, reagent cup turns
Clamping groove is provided on disk, after being embedded into clamping groove by clamping protrusion, reagent cup shell is in the axial direction and radially equal
Cup is fixed, and reagent cup is socketed on reagent cup shell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910773576.4A CN110514858A (en) | 2019-08-21 | 2019-08-21 | A kind of automatic chemiluminescence immunoassay reagent bag apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910773576.4A CN110514858A (en) | 2019-08-21 | 2019-08-21 | A kind of automatic chemiluminescence immunoassay reagent bag apparatus |
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| Publication Number | Publication Date |
|---|---|
| CN110514858A true CN110514858A (en) | 2019-11-29 |
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|---|---|---|---|
| CN201910773576.4A Pending CN110514858A (en) | 2019-08-21 | 2019-08-21 | A kind of automatic chemiluminescence immunoassay reagent bag apparatus |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960566A (en) * | 1986-09-11 | 1990-10-02 | Mochida Pharmaceutical Co., Ltd. | Chemical reaction apparatus |
| US6024921A (en) * | 1996-02-21 | 2000-02-15 | Bio Merieux, Inc. | Incubation station for test sample cards |
| CN108469529A (en) * | 2018-06-05 | 2018-08-31 | 深圳天辰医疗科技有限公司 | POCT Full-automatic chemiluminescence immunoassay analysis meters |
| CN207964642U (en) * | 2018-04-16 | 2018-10-12 | 成都普利泰生物科技有限公司 | Six transmission devices applied to chemical illumination immunity analysis instrument |
| CN210534176U (en) * | 2019-08-21 | 2020-05-15 | 成都斯马特科技有限公司 | Reagent package device for full-automatic chemiluminescence immunoassay |
-
2019
- 2019-08-21 CN CN201910773576.4A patent/CN110514858A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960566A (en) * | 1986-09-11 | 1990-10-02 | Mochida Pharmaceutical Co., Ltd. | Chemical reaction apparatus |
| US6024921A (en) * | 1996-02-21 | 2000-02-15 | Bio Merieux, Inc. | Incubation station for test sample cards |
| CN207964642U (en) * | 2018-04-16 | 2018-10-12 | 成都普利泰生物科技有限公司 | Six transmission devices applied to chemical illumination immunity analysis instrument |
| CN108469529A (en) * | 2018-06-05 | 2018-08-31 | 深圳天辰医疗科技有限公司 | POCT Full-automatic chemiluminescence immunoassay analysis meters |
| CN210534176U (en) * | 2019-08-21 | 2020-05-15 | 成都斯马特科技有限公司 | Reagent package device for full-automatic chemiluminescence immunoassay |
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