CN210294299U - Reagent suction means for full-automatic chemiluminescence immunoassay appearance - Google Patents
Reagent suction means for full-automatic chemiluminescence immunoassay appearance Download PDFInfo
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- CN210294299U CN210294299U CN201921208600.1U CN201921208600U CN210294299U CN 210294299 U CN210294299 U CN 210294299U CN 201921208600 U CN201921208600 U CN 201921208600U CN 210294299 U CN210294299 U CN 210294299U
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Abstract
The utility model discloses a reagent suction means for full-automatic chemiluminescence immunoassay appearance, including elevating system, suction means and translation mechanism, elevating system installs on translation mechanism, suction means installs on elevating system, and translation mechanism drives elevating system and pushes down to reagent strorage device translation, and elevating system pushes down and drives suction means, absorbs the reagent among the reagent strorage device, and elevating system lifts up and drives suction means and lift up, and translation mechanism translation drives the frame translation. The utility model discloses can replace the manual work to absorb required reagent, can also use on full-automatic chemiluminescence immunoassay appearance when having improved efficiency.
Description
Technical Field
The utility model relates to a biochemical analysis device especially relates to full-automatic chemiluminescence reagent suction means for immunoassay appearance.
Background
ChemiLuminescence (CL) is a type of molecular luminescence spectroscopy, and is a trace analysis method for determining the content of an analyte by detecting the ChemiLuminescence intensity of a system by using an instrument according to the principle that the concentration of the analyte in a chemical detection system and the ChemiLuminescence intensity of the system are in a linear quantitative relationship under a certain condition. The chemiluminescence method has wide application in the fields of trace metal ions, various inorganic compounds, organic compound analysis and biology.
Chemiluminescence immunoassay (CLIA) is a technique for detecting and analyzing various antigens, antibodies, hormones, enzymes, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and a high-specificity immunoreaction. Is an immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay. The chemiluminescence method has the advantages of high sensitivity, strong specificity, high accuracy, wide detection range and the like. Compared with the semi-quantitative enzyme-linked immunosorbent assay, the chemiluminescence assay is real quantitative, and the detection speed is higher and more convenient. Meanwhile, the chemiluminescent marker is stable, the effective period of the reagent is long, and the requirement of clinical application is greatly facilitated.
When carrying out chemiluminescence immunoassay, the use of reagent is indispensable, and current mode is that the manual work absorbs the reagent and carries out relevant detection, and detection efficiency is low, also can not be applicable to full-automatic chemiluminescence immunoassay appearance.
SUMMERY OF THE UTILITY MODEL
In order to overcome the above-mentioned defect that current reagent supply exists, the utility model provides a reagent suction means for full-automatic chemiluminescence immunoassay appearance, this suction means can replace the manual work to absorb required reagent, can also use on full-automatic chemiluminescence immunoassay appearance when having improved efficiency.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is:
the utility model provides a reagent suction means for full-automatic chemiluminescence immunoassay appearance which characterized in that: the device comprises an elevating mechanism, a suction mechanism and a translation mechanism, wherein the elevating mechanism is installed on the translation mechanism, the suction mechanism is installed on the elevating mechanism, the translation mechanism drives the elevating mechanism to translate towards a reagent storage device, the elevating mechanism drives the suction mechanism to press down to suck reagents in the reagent storage device, the elevating mechanism lifts up to drive the suction mechanism to lift up, and the translation mechanism drives a rack to move away from the reagent storage device.
The lifting mechanism comprises a lifting cylinder (or a screw motor, the motor drives a screw to rotate, up-and-down lifting motion can be realized, as long as lifting action can be realized, for example, gear and rack transmission is realized, the motor can drive the lifting mechanism), a reagent level pressing plate, a needle support upper plate, a rack, a needle support lower plate and a reagent level guide pillar, the needle support upper plate is installed at the upper end of the rack, the needle support lower plate is installed at the lower end of the rack, guide pillar holes are formed in the needle support upper plate and the needle support lower plate, the guide pillar penetrates through the reagent level pressing plate, one end of the guide pillar penetrates into the guide pillar hole of the needle support upper plate, the other end of the guide pillar penetrates into the guide pillar hole of the needle support lower plate, the lifting cylinder is installed on the rack, the reagent level pressing plate is.
The suction mechanism comprises a suction needle, a bottle cap pressure head and a spring, the suction needle penetrates through the reagent position pressure plate and is fixed on the reagent position pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent position pressure plate, and the suction needle is used for sucking reagents in the reagent storage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device.
The translation mechanism comprises a driving gear, a driving rack and a guide rail, the driving rack is fixed on a needle support lower plate, the needle support lower plate is installed in the guide rail, the driving gear is meshed with the driving rack, the driving gear rotates to drive the driving rack, the driving rack drives the needle support lower plate to translate on the guide rail, and the needle support lower plate translates on the guide rail to drive the suction mechanism to be close to or far away from the reagent storage device.
Compared with the prior art, the utility model discloses following beneficial effect has:
the utility model provides a reagent suction means includes elevating system, suction means and translation mechanism, elevating system installs on translation mechanism, suction means installs on elevating system, and translation mechanism drives elevating system and pushes down to reagent strorage device translation, and elevating system pushes down and drives suction means and push down, absorbs the reagent among the reagent strorage device, and elevating system lifts up and drives suction means and lift up, and translation mechanism translation drives the frame and keeps away from reagent strorage device. Translation mechanism drives the frame and moves to reagent strorage device department, then elevating system pushes down and makes suction means can absorb reagent, which kind of reagent needs, and suction needle that suction means corresponds will push down and absorb reagent, can provide corresponding reagent in real time.
The utility model discloses elevating system includes lift cylinder (or lead screw motor, and the motor drives the lead screw and rotates, can realize the oscilaltion motion as long as can realize the lift action can, for example rack and pinion transmission, the motor drives all can), reagent position clamp plate, needle support upper plate, frame, needle support hypoplastron, reagent position guide pillar, needle support upper plate is installed in the frame upper end, needle support hypoplastron is installed at the frame lower extreme, be provided with the guide pillar hole on needle support upper plate and the needle support hypoplastron, the guide pillar passes reagent position clamp plate, and one end stretches into in the guide pillar hole of needle support upper plate, and the guide pillar that one end stretched into needle support hypoplastron is downthehole, lift cylinder is installed in the frame, and reagent position clamp plate is connected on lift cylinder, and lift cylinder (or lead screw motor) drive reagent position clamp plate. The lifting mechanism has the effects of realizing the up-and-down motion of the suction mechanism, and the reagent position guide pillar has the function of guiding, thereby providing various lifting mechanisms and being convenient for selection and use.
The utility model discloses suction means passes reagent position clamp plate including absorbing needle, bottle lid pressure head and spring, absorbing the needle, and fixes on reagent position clamp plate, and the bottle lid pressure head passes and absorbs the needle, and the spring is located between bottle lid pressure head and the reagent position clamp plate, absorbs the needle and is arranged in absorbing the reagent among the reagent strorage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device. When absorbing, absorb the needle and stretch into in the reagent cup, the bottle lid pressure head is pressed on the reagent bottle, provides elasticity for the bottle lid pressure head through the effect of spring, guarantees that reagent can not reveal when absorbing, can not the spill, causes the waste.
The utility model discloses translation mechanism includes the driving gear, active rack and guide rail, the active rack is fixed on the needle holder hypoplastron, the needle holder hypoplastron is installed in the guide rail, driving gear and active rack meshing, the driving gear rotates, the active rack of drive, the active rack drives the translation of needle holder hypoplastron on the guide rail, the translation of needle holder hypoplastron on the guide rail drives suction means and is close to or keeps away from reagent strorage device, translation mechanism's effect is the translation action of realizing whole mechanism, the translation is to reagent strorage device department and absorbs the reagent, absorb and accomplish the back, retreat, give off the position, its structure also can adopt other structures that can the translation, for example the cylinder, lead screw motor etc.
Drawings
FIG. 1 is a schematic view of the structure of the present invention cooperating with other devices to form a full-automatic chemiluminescence immunoassay analyzer;
FIG. 2 is a schematic view of the structure of the reagent sucking device.
Detailed Description
The present invention will be further described with reference to the following examples, which are only some, but not all, of the examples of the present invention. Based on the embodiments in the present invention, other embodiments used by those skilled in the art without creative work belong to the protection scope of the present invention.
Example 1
The embodiment provides a reagent sucking device, which is used for sucking a reagent in a reagent storage device and sending the sucked reagent into a dropping device, and is arranged on the rear side of a capillary tube pushing device and on the left rear side of a bottom plate;
the concrete structure is as follows: the device comprises an elevating mechanism, a suction mechanism and a translation mechanism, wherein the elevating mechanism is installed on the translation mechanism, the suction mechanism is installed on the elevating mechanism, the translation mechanism drives the elevating mechanism to translate towards a reagent storage device, the elevating mechanism drives the suction mechanism to press down to suck reagents in the reagent storage device, the elevating mechanism lifts up to drive the suction mechanism to lift up, and the translation mechanism drives a rack to move away from the reagent storage device.
The lifting mechanism comprises a lifting cylinder 500 (or a lead screw motor, as long as lifting action can be realized, such as gear and rack transmission, the motor can drive the lifting mechanism), a reagent level pressing plate 501, a needle support upper plate 502, a frame 503, a needle support lower plate 504 and a reagent level guide pillar 505, wherein the needle support upper plate is installed at the upper end of the frame, the needle support lower plate is installed at the lower end of the frame, guide pillar holes are formed in the needle support upper plate and the needle support lower plate, the guide pillar penetrates through the reagent level pressing plate, one end of the guide pillar penetrates into the guide pillar hole in the needle support upper plate, the other end of the guide pillar penetrates into the guide pillar hole in the needle support lower plate, the lifting cylinder is installed on the frame, the reagent level pressing plate is connected onto the lifting cylinder, and the lifting.
The suction mechanism comprises a suction needle 506, a bottle cap pressure head 507 and a spring 508, the suction needle penetrates through the reagent position pressure plate and is fixed on the reagent position pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent position pressure plate, and the suction needle is used for sucking reagents in the reagent storage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device.
The translation mechanism comprises a driving gear 509, a driving rack 5010 and a guide rail 5011, the driving rack is fixed on a needle support lower plate, the needle support lower plate is installed in the guide rail, the driving gear is meshed with the driving rack, the driving gear rotates to drive a driving rack, the driving rack drives the needle support lower plate to translate on the guide rail, and the needle support lower plate translates on the guide rail to drive the suction mechanism to be close to or far away from the reagent storage device.
Example 2
The embodiment provides a full-automatic chemiluminescence immunoassay analyzer, which is used for full-automatically realizing all steps of chemiluminescence immunoassay, and has the following specific structure:
including bottom plate 12 and waste liquid groove, the waste liquid groove is installed in the bottom plate below, installs capillary feeding device 1, capillary ejecting device 2, capillary transfer device 3, reagent strorage device 4, reagent suction means 5, dropping liquid device 6, gas blowing device 7, sampling device 8, incubation device 9 and detection device 10 above the bottom plate, capillary feeding device 1 is used for supplying the capillary that has been coated with the antibody, capillary ejecting device 2 is used for ejecting capillary 11 from capillary feeding device 1, capillary transfer device 3 is used for transporting the capillary that is ejected to dropping liquid device 6, gas blowing device 7, sampling device 8, incubation device 9 and detection device 10 department, reagent strorage device 4 is used for supplying reagent, reagent suction means 5 is used for absorbing reagent from reagent strorage device 4 to send the reagent that absorbs to dropping liquid device 6, dropping device 6 is arranged in to capillary 11 to send into the reagent, gas blowing device 7 is arranged in cleaing away the residual liquid in the capillary, sampling device 8 is used for absorbing the detection sample to send the detection sample of absorption into capillary 11 in, incubation device 9 is used for incubation capillary 11, detection device 10 is used for detecting the luminous photon number of capillary.
The coated capillary tube is placed in a capillary tube supply device, the capillary tube supply device moves to a capillary tube pushing device, the capillary tube pushing device moves to push out the capillary tube in the capillary tube supply device, the capillary tube is transported to a sampling device by a capillary tube transport device, the capillary tube sucks a sample after sampling by the sampling device, then the capillary tube is transported to an incubation device by a transport device for incubation, after the incubation is completed, the capillary tube is transported to an air blowing device by the transport device to remove residual liquid in the capillary tube, then the capillary tube is transported to a liquid dropping device to suck cleaning liquid after the cleaning liquid is sucked by the liquid dropping device and then transported to the air blowing device to remove residual liquid, the capillary tube is repeatedly (for example, 3 times) washed by the cleaning liquid and blown to remove residual liquid, then the capillary tube is transported to the incubation device to suck a reactant, and then the capillary tube is transported to the, after the incubation is finished, the capillary tube is sent to the blowing device and the liquid dropping device again to be blown, sucked and cleaned for multiple times, the capillary tube sucks the luminescent substrate at the liquid dropping device, the capillary tube is transported to the detection device by the capillary tube transportation device, the detection device detects the capillary tube, the number of photons emitted by the capillary tube is detected, and the whole process is finished.
Claims (4)
1. The utility model provides a reagent suction means for full-automatic chemiluminescence immunoassay appearance which characterized in that: the device comprises an elevating mechanism, an absorbing mechanism and a translation mechanism, wherein the elevating mechanism is arranged on the translation mechanism, the absorbing mechanism is arranged on the elevating mechanism, the translation mechanism drives the elevating mechanism to translate towards a reagent storage device, the elevating mechanism drives the absorbing mechanism to press down to absorb reagents in the reagent storage device, the elevating mechanism lifts up to drive the absorbing mechanism to lift up, and the translation mechanism translates to drive a rack to translate.
2. The reagent sucking device for the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: the lifting mechanism comprises a lifting cylinder, a reagent level pressing plate, a needle support upper plate, a rack, a needle support lower plate and a reagent level guide pillar, the needle support upper plate is installed at the upper end of the rack, the needle support lower plate is installed at the lower end of the rack, guide pillar holes are formed in the needle support upper plate and the needle support lower plate, the guide pillar penetrates through the reagent level pressing plate, one end of the guide pillar hole extends into the guide pillar hole of the needle support upper plate, the other end of the guide pillar hole extends into the guide pillar hole of the needle support lower plate, the lifting cylinder is installed on the rack, the reagent level pressing plate is connected onto the lifting cylinder, and the lifting cylinder drives the reagent.
3. The reagent sucking device for the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: the suction mechanism comprises a suction needle, a bottle cap pressure head and a spring, the suction needle penetrates through a reagent position pressure plate and is fixed on the reagent position pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent position pressure plate, the suction needle is used for sucking reagents in the reagent storage device, the suction needle can be connected with a liquid pump through a hose, the reagents are sucked through the liquid pump, and the reagents are sucked to the liquid dropping device.
4. The reagent sucking device for the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: the translation mechanism comprises a driving gear, a driving rack and a guide rail, the driving rack is fixed on a needle support lower plate, the needle support lower plate is installed in the guide rail, the driving gear is meshed with the driving rack, the driving gear rotates to drive the driving rack, the driving rack drives the needle support lower plate to translate on the guide rail, and the needle support lower plate translates on the guide rail to drive the suction mechanism to translate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921208600.1U CN210294299U (en) | 2019-07-30 | 2019-07-30 | Reagent suction means for full-automatic chemiluminescence immunoassay appearance |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921208600.1U CN210294299U (en) | 2019-07-30 | 2019-07-30 | Reagent suction means for full-automatic chemiluminescence immunoassay appearance |
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| CN210294299U true CN210294299U (en) | 2020-04-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114199631A (en) * | 2021-12-13 | 2022-03-18 | 杭州莱和生物技术有限公司 | Amplification method for immunochromatography monitoring signal |
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2019
- 2019-07-30 CN CN201921208600.1U patent/CN210294299U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114199631A (en) * | 2021-12-13 | 2022-03-18 | 杭州莱和生物技术有限公司 | Amplification method for immunochromatography monitoring signal |
| CN114199631B (en) * | 2021-12-13 | 2022-08-12 | 杭州莱和生物技术有限公司 | Amplification method for immunochromatography monitoring signal |
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