CN210294298U - Reagent droplet forming device for full-automatic chemiluminescence immunoassay analyzer - Google Patents
Reagent droplet forming device for full-automatic chemiluminescence immunoassay analyzer Download PDFInfo
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- CN210294298U CN210294298U CN201921208598.8U CN201921208598U CN210294298U CN 210294298 U CN210294298 U CN 210294298U CN 201921208598 U CN201921208598 U CN 201921208598U CN 210294298 U CN210294298 U CN 210294298U
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Abstract
The utility model discloses a reagent liquid drop forming device for full-automatic chemiluminescence immunoassay appearance, including reagent strorage device, reagent suction means and dropping liquid device, reagent strorage device is used for depositing reagent, and reagent suction means absorbs reagent from reagent strorage device to the dropping liquid device is sent into to the reagent that will inhale and get, and the dropping liquid device extrudes reagent and forms the reagent liquid drop. The utility model discloses form the reagent liquid drop, it is not only efficient, can not cause reagent extravagant yet, but also can be applied to full-automatic chemiluminescence immunoassay appearance.
Description
Technical Field
The utility model relates to a biochemical analysis device especially relates to an utilize chemiluminescence method to carry out immunoassay's device.
Background
ChemiLuminescence (CL) is a type of molecular luminescence spectroscopy, and is a trace analysis method for determining the content of an analyte by detecting the ChemiLuminescence intensity of a system by using an instrument according to the principle that the concentration of the analyte in a chemical detection system and the ChemiLuminescence intensity of the system are in a linear quantitative relationship under a certain condition. The chemiluminescence method has wide application in the fields of trace metal ions, various inorganic compounds, organic compound analysis and biology.
Chemiluminescence immunoassay (CLIA) is a technique for detecting and analyzing various antigens, antibodies, hormones, enzymes, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and a high-specificity immunoreaction. Is an immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay. The chemiluminescence method has the advantages of high sensitivity, strong specificity, high accuracy, wide detection range and the like. Compared with the semi-quantitative enzyme-linked immunosorbent assay, the chemiluminescence assay is real quantitative, and the detection speed is higher and more convenient. Meanwhile, the chemiluminescent marker is stable, the effective period of the reagent is long, and the requirement of clinical application is greatly facilitated.
When carrying out chemiluminescence immunoassay, need use the carrier to bear the weight of the reactant and react, current carrier has micropore board and ELIAS board, the volume of getting on the sample that uses micropore board and ELIAS board is great, detection cost is higher, consequently, it produces to use the capillary as the carrier, adopt the capillary as the carrier, need adsorb reagent in the capillary, just need form reagent liquid drop this moment, the siphon power that utilizes the capillary adsorbs, the current mode is artifical with the instrument absorption reagent, then absorb in the capillary after extrusion reagent forms the liquid drop, there is following defect in this kind of mode:
the size of the manually extruded liquid drop cannot be controlled, so that the reagent cannot be sucked at one time, the reagent needs to be extruded for multiple times, the efficiency is low, or the reagent is excessive, and the reagent is wasted. The reagent is extruded by manpower, so that the efficiency is low, and the reagent can not be applied to a full-automatic chemiluminescence immunoassay analyzer.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the manual extrusion of the reagent droplets, the invention provides the reagent droplet forming device for the full-automatic chemiluminescence immunoassay analyzer.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is:
a reagent droplet forming device for a full-automatic chemiluminescence immunoassay analyzer is characterized in that: including reagent strorage device, reagent suction means and dropping liquid device, reagent strorage device is used for depositing reagent, and reagent suction means draws reagent from reagent strorage device to the dropping liquid device is sent into to the reagent that will suck, and the dropping liquid device extrudes reagent and forms the reagent liquid drop.
The reagent storage device has the specific structure that: comprises a reagent placing cup and a refrigerating device, wherein the reagent placing cup is placed on the refrigerating device, the refrigerating temperature of the refrigerating device is 2-8 ℃, and the aim is to ensure that the temperature of the reagent in the reagent placing cup is 2-8 ℃.
The refrigerating device comprises a refrigerating cup, a refrigerating piece, a temperature sensor and a heat insulation seat, wherein the refrigerating piece is located below the refrigerating cup, the heat insulation seat is sleeved on the refrigerating cup, a reagent placing cup is placed in the refrigerating cup, the refrigerating piece provides refrigeration for the refrigerating cup, the temperature sensor is installed in the refrigerating cup and is used for detecting the temperature of the refrigerating cup, the refrigerating piece is controlled to refrigerate through the temperature detected by the temperature sensor, the temperature of the refrigerating cup is ensured to be 2-8 ℃, the heat insulation seat plays a role in heat insulation of the refrigerating cup, the cold loss is reduced, and the energy consumption is reduced.
The refrigerating device further comprises a heat dissipation device, the heat dissipation device is installed below the refrigerating piece, the cold surface of the refrigerating piece is in contact with the refrigerating cup, the hot surface of the refrigerating piece is in contact with the heat dissipation device, and the heat dissipation device quickly dissipates the temperature of the refrigerating piece.
The heat dissipating device comprises a heat dissipating fan and a heat dissipating fin, the heat dissipating fin is in contact with the refrigerating fin, and an air outlet of the heat dissipating fan faces the heat dissipating fin.
The reagent placing cup is provided with a groove for placing the reagent cup containing the reagent.
The reagent suction means has the concrete structure that: the device comprises an elevating mechanism, a suction mechanism and a translation mechanism, wherein the elevating mechanism is installed on the translation mechanism, the suction mechanism is installed on the elevating mechanism, the translation mechanism drives the elevating mechanism to translate towards a reagent storage device, the elevating mechanism drives the suction mechanism to press down to suck reagents in the reagent storage device, the elevating mechanism lifts up to drive the suction mechanism to lift up, and the translation mechanism drives a rack to move away from the reagent storage device.
The lifting mechanism comprises a lifting cylinder (or a screw motor, the motor drives a screw to rotate, up-and-down lifting motion can be realized, as long as lifting action can be realized, for example, gear and rack transmission is realized, the motor can drive the lifting mechanism), a reagent level pressing plate, a needle support upper plate, a rack, a needle support lower plate and a reagent level guide pillar, the needle support upper plate is installed at the upper end of the rack, the needle support lower plate is installed at the lower end of the rack, guide pillar holes are formed in the needle support upper plate and the needle support lower plate, the guide pillar penetrates through the reagent level pressing plate, one end of the guide pillar penetrates into the guide pillar hole of the needle support upper plate, the other end of the guide pillar penetrates into the guide pillar hole of the needle support lower plate, the lifting cylinder is installed on the rack, the reagent level pressing plate is.
The suction mechanism comprises a suction needle, a bottle cap pressure head and a spring, the suction needle penetrates through the reagent position pressure plate and is fixed on the reagent position pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent position pressure plate, and the suction needle is used for sucking reagents in the reagent storage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device.
The translation mechanism comprises a driving gear, a driving rack and a guide rail, the driving rack is fixed on a needle support lower plate, the needle support lower plate is installed in the guide rail, the driving gear is meshed with the driving rack, the driving gear rotates to drive the driving rack, the driving rack drives the needle support lower plate to translate on the guide rail, and the needle support lower plate translates on the guide rail to drive the suction mechanism to be close to or far away from the reagent storage device.
The dropping device has the specific structure that: the device comprises a dripper frame, a plurality of drippers, a dripper rail bracket, a dripper rail, a dripper frame driving mechanism and a droplet size detector, wherein the plurality of drippers are arranged on the dripper frame, the dripper frame is arranged on the dripper rail, the droplet rail is arranged on the dripper rail bracket, the droplet size detector is positioned below the dripper, the droplet size detector is used for detecting the droplet size extruded by the dripper, the dripper frame driving mechanism is arranged on the dripper rail bracket and is used for driving the dripper frame to slide on the dripper rail, the dripper is connected with a liquid pump through a hose and needs any reagent, the dripper frame driving mechanism drives the dripper frame to move on the dripper rail, the corresponding dripper is positioned at the droplet size detector, the droplet is extruded, after the droplet size detected by the droplet size detector meets the set requirement, a capillary transfer device transfers a capillary, the droplets are drawn into the capillary tube by a siphon force. The droplet size detector may be an opto-coupler or a sensor.
The drip head frame driving mechanism comprises a gear, a rack and a motor, the rack is fixed on one side face of the drip head frame, the drip head is installed on the other side face of the drip head frame, the gear is meshed with the rack, the motor is electrically driven by the gear, the rack is driven by the gear to move, and the rack drives the drip head frame to slide on the drip guide rail.
And a liquid collecting cover is further installed below the dripper, is installed on the liquid dropping guide rail bracket and is used for collecting waste liquid dripped by the dripper and guiding the waste liquid into a waste liquid tank.
Compared with the prior art, the utility model discloses following beneficial effect has:
the utility model discloses a reagent strorage device, reagent suction means and dropping liquid device, reagent strorage device are used for depositing the reagent, and reagent suction means absorbs the reagent from reagent strorage device to the dropping liquid device is sent into to the reagent that will inhale and get, and the dropping liquid device extrudes reagent and forms the reagent liquid drop. Absorb reagent and send reagent to the dropping liquid device through reagent suction means, the dropping liquid device forms reagent liquid drop and supplies the capillary to adsorb, has realized the full automatization formation of reagent liquid drop, does not need artificial participation, has improved efficiency.
The utility model discloses a cup and refrigerating plant are placed to reagent, and the cup is placed on refrigerating plant to reagent, is provided with a plurality of recesses on the cup is placed to reagent, and the recess is used for placing the reagent cup of depositing reagent, and refrigerating plant refrigeration temperature is 2-8 ℃, and its purpose is exactly that the reagent temperature of guaranteeing in the reagent cup is 2-8 ℃. Reagent cups filled with different reagents can be placed in the grooves, so that the reagents are placed together, refrigeration is performed through the refrigeration device, the temperature is guaranteed, the reagent in the reagent cups can be conveniently sucked by the reagent suction device, full-automatic reagent supply is realized, manual participation is not needed, the working efficiency is improved, and supply of different reagents can be provided for a full-automatic chemiluminescence immunoassay analyzer.
The utility model discloses refrigerating plant is including the refrigeration cup, the refrigeration piece, temperature sensor and heat insulating seat, the refrigeration piece is located refrigeration cup below, heat insulating seat cover is on the refrigeration cup, the cup is placed in the refrigeration cup to reagent, the refrigeration piece provides the refrigeration for the refrigeration cup, temperature sensor installs in the refrigeration cup, a temperature for detecting the refrigeration cup, the refrigeration piece refrigeration is controlled to the temperature that detects out through temperature sensor, ensure that refrigeration cup temperature is 2-8 ℃, heat insulating seat's effect plays a thermal-insulated effect to the refrigeration cup, reduce cold volume loss, reduce the energy consumption. The refrigerating device provides cold energy, freezes the reagent, avoids reagent bad to fall.
The utility model provides a reagent suction means includes elevating system, suction means and translation mechanism, elevating system installs on translation mechanism, suction means installs on elevating system, and translation mechanism drives elevating system and pushes down to reagent strorage device translation, and elevating system pushes down and drives suction means and push down, absorbs the reagent among the reagent strorage device, and elevating system lifts up and drives suction means and lift up, and translation mechanism translation drives the frame and keeps away from reagent strorage device. Translation mechanism drives the frame and moves to reagent strorage device department, then elevating system pushes down and makes suction means can absorb reagent, which kind of reagent needs, and suction needle that suction means corresponds will push down and absorb reagent, can provide corresponding reagent in real time.
The utility model discloses elevating system includes lift cylinder (or lead screw motor, and the motor drives the lead screw and rotates, can realize the oscilaltion motion as long as can realize the lift action can, for example rack and pinion transmission, the motor drives all can), reagent position clamp plate, needle support upper plate, frame, needle support hypoplastron, reagent position guide pillar, needle support upper plate is installed in the frame upper end, needle support hypoplastron is installed at the frame lower extreme, be provided with the guide pillar hole on needle support upper plate and the needle support hypoplastron, the guide pillar passes reagent position clamp plate, and one end stretches into in the guide pillar hole of needle support upper plate, and the guide pillar that one end stretched into needle support hypoplastron is downthehole, lift cylinder is installed in the frame, and reagent position clamp plate is connected on lift cylinder, and lift cylinder (or lead screw motor) drive reagent position clamp plate. The lifting mechanism has the effects of realizing the up-and-down motion of the suction mechanism, and the reagent position guide pillar has the function of guiding, thereby providing various lifting mechanisms and being convenient for selection and use.
The utility model discloses suction means passes reagent position clamp plate including absorbing needle, bottle lid pressure head and spring, absorbing the needle, and fixes on reagent position clamp plate, and the bottle lid pressure head passes and absorbs the needle, and the spring is located between bottle lid pressure head and the reagent position clamp plate, absorbs the needle and is arranged in absorbing the reagent among the reagent strorage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device. When absorbing, absorb the needle and stretch into in the reagent cup, the bottle lid pressure head is pressed on the reagent bottle, provides elasticity for the bottle lid pressure head through the effect of spring, guarantees that reagent can not reveal when absorbing, can not the spill, causes the waste.
The utility model discloses translation mechanism includes the driving gear, active rack and guide rail, the active rack is fixed on the needle holder hypoplastron, the needle holder hypoplastron is installed in the guide rail, driving gear and active rack meshing, the driving gear rotates, the active rack of drive, the active rack drives the translation of needle holder hypoplastron on the guide rail, the translation of needle holder hypoplastron on the guide rail drives suction means and is close to or keeps away from reagent strorage device, translation mechanism's effect is the translation action of realizing whole mechanism, the translation is to reagent strorage device department and absorbs the reagent, absorb and accomplish the back, retreat, give off the position, its structure also can adopt other structures that can the translation, for example the cylinder, lead screw motor etc.
The utility model discloses a dropping device includes the dripper frame, a plurality of drippers, the dropping liquid rail bracket, the dropping liquid guide rail, dripper frame actuating mechanism and liquid droplet size detector, a plurality of drippers are installed on the dripper frame, the dripper frame is installed on the dropping liquid guide rail, the dropping liquid guide rail is installed on the dropping liquid rail bracket, liquid droplet size detector is located the dripper below, liquid droplet size detector is used for detecting the liquid droplet size that the dripper extrudes, dripper frame actuating mechanism installs on the dropping liquid rail bracket, be used for driving the dripper frame to slide on the dropping liquid guide rail, the dripper passes through the hose and links to each other with the drawing liquid pump, which kind of reagent is needed, dripper frame actuating mechanism drives the dripper frame to move on the dropping liquid droplet guide rail, let the corresponding dripper be located liquid droplet size detector department, extrude the, the capillary transport device transports the capillary to a position close to the liquid droplet, and the liquid droplet is sucked into the capillary under the action of the siphon force. The droplet size detector may be an opto-coupler or a sensor. The size of the liquid drop extruded by the dripper is detected through the liquid drop size detector, when the size of the liquid drop reaches the set size, the liquid drop size detector sends a signal to control the capillary tube to be close to the liquid drop and adsorb the liquid drop through siphon force, so that liquid cannot be extruded for many times, redundant reagents cannot be extruded once, and reagent waste cannot be caused. The automatic liquid drop of extruding, automatic absorption liquid drop, full automation mechanized operation does not need artifical the participation, has improved efficiency. Can be applied to a full-automatic chemiluminescence immunoassay analyzer.
The utility model discloses drip head frame actuating mechanism includes gear, rack and motor, and the rack is fixed on a drip head frame side, and the dripper is installed on drip head frame another side, and wheel and rack toothing, motor electric gear, gear revolve drive rack motion, and the rack drives the dripper frame and slides at the dropping liquid guide rail. Through the drive of dripper frame actuating mechanism, when needing what reagent, what actual dripper that can extrude moves to liquid drop size detector department and extrudes the liquid drop to detect the liquid drop size, detection of all liquid drop sizes can be realized to a detector, and cost reduces.
The utility model discloses the liquid collecting cover is still installed to the dripper below, and the liquid collecting cover is installed on dropping liquid guide rail bracket for collect the waste liquid that the dripper dripped, and with the waste liquid leading-in to the waste liquid groove in. Its purpose is to collect the waste liquid, avoids the waste liquid to flow indiscriminately.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention forming a full-automatic chemiluminescence immunoassay analyzer together with other devices;
FIG. 2 is a schematic view of a reagent storage device;
FIG. 3 is a schematic cross-sectional view of FIG. 2;
FIG. 4 is a schematic view of the structure of the reagent sucking device;
FIG. 5 is a schematic view of the structure of the dropping device;
FIG. 6 is a schematic view of the structure of FIG. 5 with the drip cover removed.
Reference numeral 1, a capillary tube feeding device, 2, a capillary tube pushing device, 3, a capillary tube transferring device, 4, a reagent storing device, 400, a reagent placing cup, 401, a refrigerating cup, 402, a refrigerating sheet, 403, a heat insulation seat, 404, a heat radiating device, 5, a reagent sucking device, 500, a lifting cylinder, 501, a reagent position pressing plate, 502, a needle support upper plate, 503, a frame, 504, a needle support lower plate, 505, a reagent position guide post, 506, a sucking needle, 507, a bottle cap pressing head, 508, a spring, 509, a driving gear, 5010, a driving rack, 5011, a guide rail, 6, a dropping device, 600, a dropping head frame, 601, a dropping head, 602, a dropping head guide rail support dropping, 603, a guide rail, 604, a dropping head frame driving mechanism, 605, a droplet size detector, 606, a liquid collecting cover, 7, an air blowing device, 8, a sampling device, 9, an incubation device, 10, a detection device, 11. Capillary tube 12, bottom plate 13, waste liquid groove.
Detailed Description
The present invention will be further described with reference to the following examples, which are only some, but not all, of the examples of the present invention. Based on the embodiments in the present invention, other embodiments used by those skilled in the art without creative work belong to the protection scope of the present invention.
Example 1
The embodiment provides a reagent droplet forming device, and it includes including reagent strorage device, reagent suction means and dropping liquid device, and reagent strorage device is used for depositing reagent, and reagent suction means draws reagent from reagent strorage device to send into the dropping liquid device with the reagent of drawing, the dropping liquid device extrudes reagent and forms the reagent droplet.
The reagent storage device is used for providing different reagents, and can provide a plurality of different reagents according to actual conditions. The reagent storage device is arranged on the left front side of the bottom plate, is positioned on the left side of the capillary supply device, and is positioned on the front side of the capillary pushing-out device.
The reagent storage device has the specific structure that:
comprises a reagent placing cup 400 and a refrigerating device, wherein the reagent placing cup is placed on the refrigerating device, the refrigerating temperature of the refrigerating device is 2-8 ℃, and the aim is to ensure that the temperature of the reagent in the reagent placing cup is 2-8 ℃.
The refrigerating device comprises a refrigerating cup 401, a refrigerating piece 402, a temperature sensor and a heat insulation seat 403, the refrigerating piece 402 is located below the refrigerating cup 401, the heat insulation seat 403 is sleeved on the refrigerating cup, a reagent placing cup is placed in the refrigerating cup, the refrigerating piece provides refrigeration for the refrigerating cup, the temperature sensor is installed in the refrigerating cup and used for detecting the temperature of the refrigerating cup, the refrigerating piece is controlled to refrigerate through the temperature detected by the temperature sensor, the temperature of the refrigerating cup is ensured to be 2-8 ℃, the heat insulation seat plays a role in heat insulation of the refrigerating cup, the cold loss is reduced, and the energy consumption is reduced.
The refrigerating device further comprises a heat dissipation device 404, the heat dissipation device is installed below the refrigerating sheet, the cold surface of the refrigerating sheet is in contact with the refrigerating cup, the hot surface of the refrigerating sheet is in contact with the heat dissipation device, and the heat dissipation device quickly dissipates the temperature of the refrigerating sheet.
The heat dissipating device comprises a heat dissipating fan and a heat dissipating fin, the heat dissipating fin is in contact with the refrigerating fin, and an air outlet of the heat dissipating fan faces the heat dissipating fin.
The reagent placing cup is provided with a groove for placing the reagent cup containing the reagent.
The reagent sucking device is used for sucking the reagent in the reagent storage device and sending the sucked reagent into the dropping device, and the reagent sucking device is arranged on the rear side of the capillary tube pushing device and on the left rear side of the bottom plate;
the concrete structure is as follows: the device comprises an elevating mechanism, a suction mechanism and a translation mechanism, wherein the elevating mechanism is installed on the translation mechanism, the suction mechanism is installed on the elevating mechanism, the translation mechanism drives the elevating mechanism to translate towards a reagent storage device, the elevating mechanism drives the suction mechanism to press down to suck reagents in the reagent storage device, the elevating mechanism lifts up to drive the suction mechanism to lift up, and the translation mechanism drives a rack to move away from the reagent storage device.
The lifting mechanism comprises a lifting cylinder 500 (or a lead screw motor, as long as lifting action can be realized, such as gear and rack transmission, the motor can drive the lifting mechanism), a reagent level pressing plate 501, a needle support upper plate 502, a frame 503, a needle support lower plate 504 and a reagent level guide pillar 505, wherein the needle support upper plate is installed at the upper end of the frame, the needle support lower plate is installed at the lower end of the frame, guide pillar holes are formed in the needle support upper plate and the needle support lower plate, the guide pillar penetrates through the reagent level pressing plate, one end of the guide pillar penetrates into the guide pillar hole in the needle support upper plate, the other end of the guide pillar penetrates into the guide pillar hole in the needle support lower plate, the lifting cylinder is installed on the frame, the reagent level pressing plate is connected onto the lifting cylinder, and the lifting.
The suction mechanism comprises a suction needle 506, a bottle cap pressure head 507 and a spring 508, the suction needle penetrates through the reagent position pressure plate and is fixed on the reagent position pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent position pressure plate, and the suction needle is used for sucking reagents in the reagent storage device. The suction needle can be connected with a liquid pump through a hose, and can suck reagent through the liquid pump and suck the reagent to the dropping device.
The translation mechanism comprises a driving gear 509, a driving rack 5010 and a guide rail 5011, the driving rack is fixed on a needle support lower plate, the needle support lower plate is installed in the guide rail, the driving gear is meshed with the driving rack, the driving gear rotates to drive a driving rack, the driving rack drives the needle support lower plate to translate on the guide rail, and the needle support lower plate translates on the guide rail to drive the suction mechanism to be close to or far away from the reagent storage device.
The dropping device is used for forming reagent drops and supplying reagent to the capillary. The dropping liquid device is installed on the right side of bottom plate, and reagent suction means sends reagent and hose into dropping liquid device department through imbibition pump with reagent.
The dropping device has the specific structure that: the device comprises a dripper frame 600, a plurality of drippers 601, a dripper rail bracket 602, a dripper rail 603, a dripper frame driving mechanism 604 and a droplet size detector 605, wherein the drippers are arranged on the dripper frame, the dripper frame is arranged on the dripper rail, the dripper rail is arranged on the dripper rail bracket, the dripper rail bracket is arranged on a bottom plate, the droplet size detector is arranged on the dripper rail bracket, the droplet size detector is positioned below the dripper and used for detecting the size of droplets extruded by the drippers, the dripper frame driving mechanism is arranged on the dripper rail bracket and used for driving the dripper frame to slide on the dripper rail, the dripper is connected with a liquid pump through a hose and needs which reagent, the dripper frame driving mechanism drives the dripper frame to move on the dripper rail, so that the corresponding dripper is positioned at the droplet size detector to extrude the droplets, and after the droplet size detected by the droplet, the capillary transport device transports the capillary to a position close to the liquid droplet, and the liquid droplet is sucked into the capillary under the action of the siphon force. The droplet size detector may be an opto-coupler or a sensor.
The drip head frame driving mechanism comprises a gear, a rack and a motor, the rack is fixed on one side face of the drip head frame, the drip head is installed on the other side face of the drip head frame, the gear is meshed with the rack, the motor is electrically driven by the gear, the rack is driven by the gear to move, and the rack drives the drip head frame to slide on the drip guide rail.
A liquid collecting cover 606 is further installed below the dripper, and the liquid collecting cover 606 is installed on the dripping guide rail bracket and used for collecting waste liquid dripped by the dripper and guiding the waste liquid into a waste liquid groove. The waste liquid tank is arranged below the bottom plate.
Example 2
The embodiment provides a full-automatic chemiluminescence immunoassay analyzer, which is used for full-automatically realizing all steps of chemiluminescence immunoassay, and has the following specific structure:
including bottom plate 12 and waste liquid groove, the waste liquid groove is installed in the bottom plate below, installs capillary feeding device 1, capillary ejecting device 2, capillary transfer device 3, reagent strorage device 4, reagent suction means 5, dropping liquid device 6, gas blowing device 7, sampling device 8, incubation device 9 and detection device 10 above the bottom plate, capillary feeding device 1 is used for supplying the capillary that has been coated with the antibody, capillary ejecting device 2 is used for ejecting capillary 11 from capillary feeding device 1, capillary transfer device 3 is used for transporting the capillary that is ejected to dropping liquid device 6, gas blowing device 7, sampling device 8, incubation device 9 and detection device 10 department, reagent strorage device 4 is used for supplying reagent, reagent suction means 5 is used for absorbing reagent from reagent strorage device 4 to send the reagent that absorbs to dropping liquid device 6, dropping device 6 is arranged in to capillary 11 to send into the reagent, gas blowing device 7 is arranged in cleaing away the residual liquid in the capillary, sampling device 8 is used for absorbing the detection sample to send the detection sample of absorption into capillary 11 in, incubation device 9 is used for incubation capillary 11, detection device 10 is used for detecting the luminous photon number of capillary.
The coated capillary tube is placed in a capillary tube supply device, the capillary tube supply device moves to a capillary tube pushing device, the capillary tube pushing device moves to push out the capillary tube in the capillary tube supply device, the capillary tube is transported to a sampling device by a capillary tube transport device, the capillary tube sucks a sample after sampling by the sampling device, then the capillary tube is transported to an incubation device by the transport device for incubation, after the incubation is completed, the capillary tube is transported to an air blowing device by the transport device to remove residual liquid in the capillary tube, then the capillary tube is transported to a liquid dropping device to remove the residual liquid by the air blowing device after the capillary tube absorbs the cleaning liquid, the capillary tube is transported to the liquid dropping device to absorb a reactant after the capillary tube is cleaned by the cleaning liquid for a plurality of times (for example, 3 times) and the residual liquid is removed by the air blowing, and then the capillary tube is transported to the incubation device by, after the incubation is finished, the capillary tube is sent to the blowing device and the liquid dropping device again to be blown, sucked and cleaned for multiple times, the capillary tube sucks the luminescent substrate at the liquid dropping device, the capillary tube is transported to the detection device by the capillary tube transportation device, the detection device detects the capillary tube, the number of photons emitted by the capillary tube is detected, and the whole process is finished.
Claims (7)
1. A reagent droplet forming device for a full-automatic chemiluminescence immunoassay analyzer is characterized in that: including reagent strorage device, reagent suction means and dropping liquid device, reagent strorage device is used for depositing reagent, and reagent suction means draws reagent from reagent strorage device to the dropping liquid device is sent into to the reagent that will suck, and the dropping liquid device extrudes reagent and forms the reagent liquid drop.
2. The reagent droplet forming apparatus according to claim 1, wherein: the reagent storage device has the specific structure that: including reagent placement cup and refrigerating plant, the cup is placed on refrigerating plant to the reagent, be provided with a plurality of recesses on the reagent placement cup, refrigerating plant is including refrigeration cup, refrigeration piece, temperature sensor and heat insulating seat, and the refrigeration piece is located refrigeration cup below, and heat insulating seat cover is on the refrigeration cup, and the cup is placed in the refrigeration cup to the reagent, and the refrigeration piece provides the refrigeration for the refrigeration cup, and temperature sensor is used for detecting the temperature of refrigeration cup.
3. The reagent droplet forming apparatus according to claim 1, wherein: the reagent suction device comprises a lifting mechanism, a suction mechanism and a translation mechanism, wherein the lifting mechanism is installed on the translation mechanism, the suction mechanism is installed on the lifting mechanism, the translation mechanism drives the lifting mechanism to translate towards the reagent storage device, the lifting mechanism is pressed down to drive the suction mechanism to press down to suck the reagent in the reagent storage device, the lifting mechanism is lifted up to drive the suction mechanism to lift up, and the translation mechanism translates to drive the rack to be far away from the reagent storage device.
4. The reagent droplet forming apparatus according to claim 3, wherein: the suction mechanism comprises a suction needle, a bottle cap pressure head and a spring, the suction needle penetrates through the reagent level pressure plate and is fixed on the reagent level pressure plate, the bottle cap pressure head penetrates through the suction needle, the spring is located between the bottle cap pressure head and the reagent level pressure plate, the suction needle is used for sucking reagents in the reagent storage device, and the suction needle is connected with the liquid pump through a hose.
5. The reagent droplet forming apparatus according to claim 1, wherein: the dropping liquid device is including dripper frame, a plurality of drippers, dropping liquid guide rail support, dropping liquid guide rail, dripper frame actuating mechanism and liquid droplet size detector, and a plurality of drippers are installed on dripper frame, and dripper frame installs on the dropping liquid guide rail, and the dropping liquid guide rail is installed on dropping liquid guide rail support, and liquid droplet size detector installs on dropping liquid guide rail support, and liquid droplet size detector is located the dripper below, and liquid droplet size detector is used for detecting the liquid droplet size that the dripper extruded, and dripper frame actuating mechanism installs on dropping liquid guide rail support for it slides on the dropping liquid guide rail to drive the dripper frame, the dripper passes through the hose and links to each other with the drawing liquid pump.
6. The reagent droplet forming apparatus according to claim 5, wherein: the drip head frame driving mechanism comprises a gear, a rack and a motor, the rack is fixed on one side face of the drip head frame, the drip head is installed on the other side face of the drip head frame, the gear is meshed with the rack, the motor is electrically driven by the gear, the rack is driven by the gear to move, and the rack drives the drip head frame to slide on the drip guide rail.
7. The reagent droplet forming apparatus according to claim 5, wherein: and a liquid collecting cover is further installed below the dripper, is installed on the liquid dropping guide rail bracket and is used for collecting waste liquid dripped by the dripper and guiding the waste liquid into a waste liquid tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921208598.8U CN210294298U (en) | 2019-07-30 | 2019-07-30 | Reagent droplet forming device for full-automatic chemiluminescence immunoassay analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921208598.8U CN210294298U (en) | 2019-07-30 | 2019-07-30 | Reagent droplet forming device for full-automatic chemiluminescence immunoassay analyzer |
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| CN210294298U true CN210294298U (en) | 2020-04-10 |
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| CN201921208598.8U Active CN210294298U (en) | 2019-07-30 | 2019-07-30 | Reagent droplet forming device for full-automatic chemiluminescence immunoassay analyzer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116660525A (en) * | 2023-07-25 | 2023-08-29 | 潍坊安普未来生物科技有限公司 | Colloidal gold paper strip detection device and detection method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116660525A (en) * | 2023-07-25 | 2023-08-29 | 潍坊安普未来生物科技有限公司 | Colloidal gold paper strip detection device and detection method |
| CN116660525B (en) * | 2023-07-25 | 2023-09-19 | 潍坊安普未来生物科技有限公司 | Colloidal gold paper strip detection device and detection method |
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