CN113670900A - Multichannel chemiluminescence immunoassay analyzer - Google Patents
Multichannel chemiluminescence immunoassay analyzer Download PDFInfo
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- CN113670900A CN113670900A CN202111043685.4A CN202111043685A CN113670900A CN 113670900 A CN113670900 A CN 113670900A CN 202111043685 A CN202111043685 A CN 202111043685A CN 113670900 A CN113670900 A CN 113670900A
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Abstract
The invention discloses a multi-channel chemiluminescence immunoassay analyzer, which comprises: the reagent strip translation device comprises at least two groups of reagent strip translation modules capable of moving back and forth, wherein each group of reagent strip translation modules comprises a reagent strip translation table, and a reagent strip rack and reagent strips are arranged on the reagent strip translation table; the automatic sample adding module comprises a sample adding driving mechanism, a sampling pump and a sampling head; the liquid suction reaction module comprises a liquid suction lifting mechanism, a liquid suction assembly and a liquid suction back head assembly; the liquid suction assembly comprises a liquid suction motor, a driving plate, a liquid suction cylinder and a liquid suction head; the liquid suction head withdrawing assembly comprises a head withdrawing plate and a head withdrawing guide shaft, the driving plate pushes the head withdrawing guide shaft to drive the head withdrawing plate to move downwards, and the head withdrawing plate pushes the liquid suction head to withdraw the liquid suction head; the detection module comprises a detection assembly and a detection moving mechanism, the detection moving mechanism drives the detection assembly to move left and right, and the detection assembly performs luminescence test on reaction substances on the reagent strip. The analyzer is compact in structure, high in modularization degree and automation degree, and high in detection efficiency.
Description
Technical Field
The invention relates to the technical field of chemiluminescence immunoassay, in particular to a multi-channel chemiluminescence immunoassay analyzer.
Background
Chemiluminescence analysis is an analytical method for determining the content of a substance based on the intensity of radiant light generated by a chemical reaction. The chemiluminescence immune analysis combines a chemiluminescence system with immune reaction, labels antibodies or antigens and the like with substances related to chemiluminescence, and after the substances react with the antigens or antibodies to be detected, the free chemiluminescence labels are separated, and other related substances of the chemiluminescence system are added to generate chemiluminescence, so that the quantitative or qualitative detection of the antigens or antibodies and the like is carried out.
The chemiluminescence immunoassay technology has high accuracy and specificity and is one of important technologies in the detection method. Chemiluminescence immunoassay technology is widely used in-vitro diagnosis experiments in the aspects of body immune function, infectious diseases, endocrine function, tumor markers, sex hormones, thyroid function and the like as a main means for disease diagnosis.
The modularization degree of the existing chemiluminescence immunoassay analyzer is not high, the expansibility of a reaction channel is not high, the automation degree is not high, and the detection efficiency is lower.
Disclosure of Invention
In order to solve the above technical problems, the present invention aims to provide a multi-channel chemiluminescence immunoassay analyzer; the analyzer is compact in structure, high in modularization degree and automation degree, and high in detection efficiency.
In order to achieve the technical purpose and achieve the technical effect, the invention is realized by the following technical scheme:
a multi-channel chemiluminescent immunoassay analyzer comprising:
the reagent strip translation device comprises at least two groups of reagent strip translation modules capable of moving back and forth, wherein each group of reagent strip translation modules comprises a reagent strip translation table, a reagent strip rack and reagent strips are arranged on the reagent strip translation table, the reagent strip rack presses the reagent strips, and a plurality of hole positions are formed in the reagent strips;
the automatic sample adding module comprises a sample adding driving mechanism, a sampling pump and a sampling head connected with the sampling pump; the sampling head sucks a sample under the action of the sampling pump, and the sampling driving mechanism drives the sampling head to move so as to fill the sample into a chamber corresponding to the reagent strip; the automatic sample adding module also comprises a head removing frame, wherein a bayonet is arranged on the head removing frame; the sampling head moves to the bayonet and falls off under the action of the bayonet when rising;
the liquid suction reaction module comprises a liquid suction lifting mechanism, a liquid suction assembly and a liquid suction back head assembly; the imbibition lifting mechanism drives the imbibition component to carry out lifting motion; the liquid suction assembly comprises a liquid suction motor, a driving plate, a liquid suction cylinder and a liquid suction head, the liquid suction motor drives the driving plate to move, and the driving plate acts on a cylinder rod of the liquid suction cylinder to enable the liquid suction head connected with the liquid suction cylinder to suck and release liquid corresponding to a hole position of the reagent strip; the liquid suction head withdrawing assembly comprises a head withdrawing plate and a head withdrawing guide shaft, wherein the head withdrawing plate is provided with a cylinder through hole, a liquid suction cylinder penetrates through the cylinder through hole, and the head withdrawing plate is positioned above the liquid suction head; the lower end of the head withdrawing guide shaft is connected with the head withdrawing plate; under the drive of the liquid suction motor, the driving plate pushes the head withdrawing guide shaft to drive the head withdrawing plate to move downwards, and the head withdrawing plate pushes the liquid suction head to withdraw the liquid suction head; the head withdrawing plate is provided with a membrane pricking head and a pressing rod extending downwards, and the pressing rod is sleeved with a pressure spring; and the pressure lever is positioned above the reagent strip rack; when the membrane pricking head withdraws after pricking the aluminum membrane on the reagent strip, the pressure lever presses the reagent rack;
the detection module comprises a detection assembly and a detection moving mechanism, the detection moving mechanism drives the detection assembly to move left and right, and the detection assembly performs luminescence test on reaction substances on the reagent strip.
Furthermore, a pressure sensor is arranged on the sampling pump to detect the liquid level of the sample.
Furthermore, the front end of the reagent strip translation table is also provided with a sample detection groove, a transmitting end circuit board and a receiving end circuit board are arranged in the sample detection groove, and after a sampling head for sucking samples extends into the sample detection groove, the transmitting end circuit board and the receiving end circuit board are matched to analyze signals so as to judge the types of the samples.
Furthermore, the analyzer also comprises a magnetic bead separation module, wherein the magnetic bead separation module comprises a magnet support, a magnet arranged on the magnet support and a magnet driving mechanism for driving the magnet support to move back and forth; the magnet bracket is provided with a separation cavity matched with the liquid suction head, and the magnet is positioned at the lower part of the separation cavity; after the magnet support moves in place, the liquid suction head enters the separation cavity, and the magnet adsorbs and separates magnetic beads in the liquid suction head.
Further, this analysis appearance still includes sample test-tube rack, sample headstock, imbibition headstock, sample head waste material box and imbibition head waste material box, and sample test-tube rack and sample headstock are located the left side of reagent strip translation module, and sample head waste material box is located the below of taking off the headstock, and imbibition headstock and imbibition head waste material box are located the front end of reagent strip platform.
Furthermore, the detection assembly comprises a photomultiplier tube, an optical fiber, a light blocking shutter, a shutter cabin body and a rotary electromagnet, the light blocking shutter is installed on the shutter cabin body, light transmission holes are formed in the light blocking shutter and the shutter cabin body, the optical fiber is installed below the light transmission holes of the shutter cabin body, the photomultiplier tube is installed above the light transmission holes of the shutter cabin body, the light blocking shutter is connected with the rotary electromagnet, and the rotary electromagnet drives the light blocking shutter to rotate so as to control the opening and closing of the light blocking shutter.
Furthermore, the detection assembly further comprises a shutter opening and closing detection assembly, the shutter opening and closing detection assembly comprises an optical coupler baffle, a first optical coupler and a second optical coupler, the optical coupler baffle is connected with the rotary electromagnet, and a first notch and a second notch are formed in the optical coupler baffle; the first gap is matched with the first optocoupler, and the second gap is matched with the second optocoupler so as to detect the opening and closing of the light blocking shutter.
Furthermore, the detection assembly further comprises a lifting and pressing mechanism, the lifting and pressing mechanism comprises a pressing motor, a pressing spring seat and a pressing support, the pressing motor is connected with the pressing spring seat, the pressing spring seat is connected with the pressing support, and the pressing support is connected with the shutter cabin body.
The invention has the beneficial effects that:
the analyzer comprises an automatic sample adding module, a reagent strip translation module, a liquid absorption reaction module, a magnetic bead separation module and a detection module; the automatic sample adding module can automatically add a sample to the reagent strip; the liquid absorption reaction module and the reagent strip translation module are matched to realize the transfer and uniform mixing of liquid among all pore sites on the reagent strip, so that the incubation reaction is completed; the magnetic bead separation module can realize automatic adsorption and separation of magnetic beads in the reagent strip so as to complete the magnetic bead screening process; the detection module can detect the luminous value of the reacted substance so as to realize the content analysis of the substance to be detected;
the automatic sample adding module is provided with a head removing structure, and the liquid absorption reaction module is provided with a liquid absorption head withdrawing component; the sampling head in the automatic sample adding module can be taken off under the matching of the sample adding driving mechanism and the head removing frame; a liquid suction back head component in the liquid suction reaction module drives a driving plate to move by using a liquid suction motor, the driving plate pushes a back head guide shaft, and the back head guide shaft drives a back head plate to move downwards to take off a liquid suction head; the head dropping structure and the design of the liquid suction and withdrawing component facilitate the replacement and the recovery of the suction head (the liquid suction head and the sampling head);
in the imbibition reaction module, a pressure lever is arranged on the head withdrawing plate, and a pressure spring is sleeved on the pressure lever; when the film binding head rises after puncturing the aluminum film on the reagent strip, the pressure rod presses the reagent strip rack, so that the reagent strip can be prevented from being brought up when the film binding head rises.
A sample detection groove is arranged on the reagent strip translation table, and a transmitting end circuit board and a receiving end circuit board are arranged in the sample detection groove; after the sampling head which absorbs the samples extends into the sample detection groove, the transmitting end circuit board and the receiving end circuit board are matched to analyze the transmittance signal so as to judge the types of the samples, and further, the related parameters of the samples can be conveniently determined during detection.
The detection assembly further comprises a shutter opening and closing detection assembly, and the shutter opening and closing detection assembly comprises an optical coupler baffle, a first optical coupler and a second optical coupler; when the light blocking shutter is opened, the rotary electromagnet also enables the optical coupler baffle to rotate, a first notch in the optical coupler baffle is staggered with the position of the first optical coupler, the first optical coupler blocks light, a second notch in the optical coupler baffle is correspondingly superposed with the position of the second optical coupler, and the second optical coupler does not block light; when the light blocking shutter is closed, the corresponding state of the two gaps on the optical coupler baffle and the positions of the two optical couplers is opposite to that when the light blocking shutter is opened; so, utilize this shutter switching detection subassembly, can detect whether the shutter that is in the light is closed when not carrying out sample analysis work to guarantee that photomultiplier can shield external environment light when out of work, in order to eliminate the influence of environment light to photomultiplier, avoid photomultiplier to expose for a long time and cause the damage under environment light.
Drawings
Fig. 1 is a schematic perspective view of a multi-channel chemiluminescence immunoassay analyzer according to an embodiment of the invention.
Fig. 2 is a schematic structural diagram of a reagent strip translation module in a multi-channel chemiluminescent immunoassay analyzer according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of an automatic sample adding module in a multi-channel chemiluminescence immunoassay analyzer according to an embodiment of the invention.
Fig. 4 is a schematic structural diagram of a liquid-absorbing reaction module in a multi-channel chemiluminescent immunoassay analyzer according to an embodiment of the present invention.
Fig. 5 is a schematic structural diagram of a magnetic bead separation module in a multi-channel chemiluminescent immunoassay analyzer according to an embodiment of the present invention.
Fig. 6 is a schematic structural diagram of a detection module in a multi-channel chemiluminescence immunoassay analyzer according to an embodiment of the invention.
Fig. 7 is an enlarged schematic view of a portion a of fig. 6.
Fig. 8 is a schematic partial exploded view of a detection module in a multi-channel chemiluminescent immunoassay analyzer according to an embodiment of the present invention.
Description of reference numerals:
1: a reagent strip translation module; 101: a reagent strip translation stage; 102: a reagent strip holder; 103: a reagent strip; 104: a liquid suction head frame; 105: a liquid suction head waste box; 106: a translation frame; 107: a reagent strip translation motor; 108: the reagent strip translation slide rail; 109: a reagent strip translation slide block; 110: a sample detection tank; 2: a sample automatic sample adding module; 201: a sampling pump; 202: a sampling head; 203: sampling an X-direction slide rail; 204: a sample adding X-direction sliding block; 205: sample adding X-direction motor; 206: sampling Y-direction sliding rails; 207: a sample adding Y-direction sliding block; 208: a sample adding Y-direction motor; 209: sample adding Z-direction slide rails; 210: a sample adding Z-direction sliding block; 211: a sample adding Z-direction motor; 212: taking off the head frame; 2121: a bayonet; 3: a liquid suction reaction module; 301: a liquid suction lifting frame; 302: a liquid suction lifting motor; 303: a liquid suction lifting slide rail; 304: a liquid suction lifting slide block; 305: a liquid suction sliding frame; 306: a liquid suction motor; 307: a drive plate; 3071: pulling the notch; 308: a liquid suction cylinder; 309: a liquid suction head; 310: a sliding shaft; 311: withdrawing the head plate; 312: a head withdrawing guide shaft; 313: connecting blocks; 314: pushing the nut; 315: a pressure lever; 316: a membrane binding head; 317: a pressure spring; 4: a magnetic bead separation module; 401: a magnet holder; 4011: a separation chamber; 402: a magnet; 403: a magnet-driven motor; 404: a linear axis; 5: a detection module; 501: a transverse driving motor; 502: transversely moving the slide rail; 503: transversely moving the sliding table; 504: a photomultiplier tube; 505: an optical fiber; 506: a light blocking shutter; 507: a shutter cabin body; 508: rotating the electromagnet; 509: a shutter housing cover; 510: a light-tight tube; 511: an optocoupler baffle; 5111: a first notch; 5112: a second notch; 512: a first optical coupler; 513: a second optocoupler; 514: a compacting motor; 515: a compression spring seat; 516: compressing the bracket; 6: a whole machine bottom plate; 601: a sample test tube rack; 602: a test tube; 603: a sampling head frame; 604: sampling head waste material box.
Detailed Description
The following detailed description of the preferred embodiments of the present invention, taken in conjunction with the accompanying drawings, will make the advantages and features of the invention easier to understand by those skilled in the art, and thus will clearly and clearly define the scope of the invention.
In the description of the present invention, it is to be understood that the terms "front", "rear", "left", "right", "upper", "lower", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the preferred embodiment of the multi-channel chemiluminescence immunoassay analyzer shown in fig. 1, the analyzer comprises a reagent strip translation module 1, an automatic sample adding module 2, a liquid absorption reaction module 3, a magnetic bead separation module 4 and a detection module 5; all modules are arranged on a whole machine bottom plate 6 in the shell; the analyzer is also provided with a control module to automatically control the operation of other modules.
As shown in fig. 1 and 2, in the present embodiment, the number of the reagent strip translation modules 1 is four; each group of reagent strip translation modules 1 comprises a reagent strip translation table 101, a reagent strip rack 102 and reagent strips 103 are arranged on the reagent strip translation table 101, the reagent strip rack 102 presses the reagent strips 103, and a plurality of hole sites including sample hole sites, reagent hole sites, reaction hole sites and detection hole sites are arranged on the reagent strips 103; the front end of the reagent strip translation table 101 is provided with a liquid absorption head frame 104 and a liquid absorption head waste material box 105, and the liquid absorption head frame 104 is provided with a liquid absorption head 309; the reagent strip translation table 101 is arranged on a translation frame 106, and the translation frame 106 is arranged on a reagent strip translation driving mechanism; the reagent strip translation driving mechanism comprises a reagent strip translation motor 107, reagent strip translation slide rails 108 arranged in front and back, and a reagent strip translation slide block 109 arranged on the reagent strip translation slide rails 108; the reagent strip translation motor 107 drives the reagent strip translation sliding block 109 to move back and forth along the reagent strip translation sliding rail 108 through a synchronous belt transmission mechanism, and further drives the translation frame 106 connected with the reagent strip translation sliding block 109 to move back and forth, so that the reagent strip translation table 101 can move back and forth.
As shown in fig. 3, the automatic sample adding module 2 includes a sample adding driving mechanism, a sampling pump 201, and a sampling head 202 connected to the sampling pump 201; the sample adding driving mechanism comprises a sample adding X-direction slide rail 203, a sample adding X-direction slide block 204, a sample adding X-direction motor 205, a sample adding Y-direction slide rail 206, a sample adding Y-direction slide block 207, a sample adding Y-direction motor 208, a sample adding Z-direction slide rail 209, a sample adding Z-direction slide block 210 and a sample adding Z-direction motor 211; the sample-adding X-direction motor 205 drives the sampling head 202 and the sampling pump 201 to move left and right under the coordination of the sample-adding X-direction slide rail 203 and the sample-adding X-direction slide block 204; the sample-adding Y-direction motor 208 drives the sampling head 202 and the sampling pump 201 to move back and forth under the coordination of the sample-adding Y-direction slide rail 206 and the sample-adding Y-direction slide block 207; the sample-adding Z-direction motor 211 drives the sampling head and the sampling pump to move up and down under the coordination of the sample-adding Z-direction slide rail 209 and the sample-adding Z-direction slide block 210.
As shown in fig. 1, a sample tube rack 601 and a sampling head rack 603 are arranged at the front end of the left side of the complete machine bottom plate 6, a test tube 602 is placed on the sample tube rack 601, a sampling head 202 is placed on the sampling head rack 603, and a sample is stored in the test tube 602; when the sampling pump 201 is located at the position of the sampling head rack 603, the sampling pump 201 is inserted into the sampling head 202, and when the sampling head 202 moves to the sample test tube rack position, the sampling head 202 sucks a sample under the action of the sampling pump 201; under the driving of the sample adding driving mechanism, the sampling head 202 moves to the corresponding reagent strip translation module 1, and the sample is added to the sample hole position on the reagent strip 103.
Wherein, the sampling pump 201 is provided with a pressure sensor; when the sampling head 202 probes liquid, the piston of the pump body exhausts outwards, when the piston of the pump body approaches a liquid surface, the exhaust pressure changes, the pressure sensor monitors the air pressure change in real time, and the control software controls the liquid transfer pump to probe a certain position in the test tube according to a related pressure value and an algorithm, so that related samples are sucked. In addition, when a sample is sucked, a blood sample may generate a clot to block a sampling head, so that the sample is failed to be sucked, and detection is affected, therefore, in the sample sucking process of the sampling pump 201, the pressure sensor monitors a pressure signal in real time, when the pressure change generated by sucking the clot reaches a threshold value set by a program, the control program controls the sampling pump 201 to stop sucking the sample for the time, and gives a relevant prompt to improve the accuracy of sample sucking operation.
As shown in fig. 1, the automatic sample adding module 2 further includes a head removing frame 212, and a bayonet 2121 is provided on the head removing frame 212; the sampling head 202 moves to the notch 2121 and, when it rises, it is detached by the notch 2121. The sample head waste box 604 is located below the knockout frame 212, and the removed sample 202 falls into the sample head waste box 604.
Furthermore, as shown in fig. 1 and 2, the front end of the reagent strip translation stage 101 is further provided with a sample detection groove 110, the sample detection groove 110 is provided with a transmitting end circuit board and a receiving end circuit board, and after the sampling head 202 sucking the sample extends into the sample detection groove 110, the transmitting end circuit board and the receiving end circuit board cooperate to analyze the signal so as to determine the type of the sample.
As shown in fig. 4, the pipetting reaction module 3 includes a pipetting elevating mechanism, a pipetting assembly and a pipetting and withdrawing assembly; the imbibition lifting mechanism drives the imbibition component to carry out lifting motion; specifically, the liquid suction lifting mechanism comprises a liquid suction lifting frame 301, a liquid suction lifting motor 302 arranged on the liquid suction lifting frame 301, a liquid suction lifting slide rail 303 and a liquid suction lifting slide block 304 in sliding fit with the liquid suction lifting slide rail 303, wherein the liquid suction lifting motor 302 is connected with a liquid suction sliding frame 305 through a screw-nut transmission mechanism, the liquid suction assembly is arranged on the liquid suction sliding frame 305, and the liquid suction sliding frame 305 is also in sliding connection with the liquid suction lifting slide rail 303 through the liquid suction lifting slide block 304; the imbibition lifting motor 302 drives the imbibition component to move up and down under the matching of the imbibition lifting slide block 304 and the imbibition lifting slide rail 303 through a screw-nut transmission mechanism; the liquid suction assembly comprises a liquid suction motor 306, a driving plate 307, a liquid suction cylinder 308 and a liquid suction head 309, wherein the liquid suction motor 306 is mounted on a liquid suction sliding frame 305, and the liquid suction motor 306 is connected with the driving plate 307 through a screw rod shaft; two sliding shafts 310 are also arranged on the liquid suction sliding frame 305, and the sliding shafts 310 penetrate through the driving plate 307; a suction cylinder 308 is mounted on the lower plate of the suction carriage 305; a pulling notch 3071 is formed in the front side of the driving plate 307, and the head end of a cylinder rod of the liquid suction cylinder 308 penetrates through the pulling notch 3071; the liquid suction motor 306 drives the driving plate 307 to move along the sliding shaft 310, the pulling notch 3071 is used for pulling the air cylinder rod to move, air pressure change is formed, further, the suction force of the liquid suction air cylinder 308 is formed, and the liquid suction head 309 connected with the liquid suction air cylinder 308 is enabled to suck and release liquid corresponding to the hole position of the reagent strip 103. The liquid suction head withdrawing assembly comprises a head withdrawing plate 311 and a head withdrawing guide shaft 312, wherein the head withdrawing plate 311 is connected with a connecting block 313, and the connecting block 313 is sleeved on a cylinder body of the liquid suction cylinder 308; the head withdrawing plate 311 is provided with a cylinder through hole, the liquid suction cylinder 308 penetrates through the cylinder through hole, the liquid suction head 309 is arranged at the lower end of the liquid suction cylinder 308, and the head withdrawing plate 311 is positioned above the liquid suction head 309; the lower end of the head withdrawing guide shaft 312 is connected with the head withdrawing plate 311, the upper end of the head withdrawing guide shaft 312 passes through the lower plate of the liquid suction sliding frame 305, the upper end of the head withdrawing guide shaft 312 is provided with a push nut 314, and the upper end of the head withdrawing guide shaft 312 is also sleeved with a spring; under the driving of the liquid suction motor 306, the driving plate 307 pushes the head withdrawing guide shaft 312 to drive the head withdrawing plate 311 to move downwards, the head withdrawing plate 311 pushes the liquid suction head 309 to withdraw the liquid suction head 309 from the liquid suction cylinder 308, and the liquid suction head falls into the liquid suction head waste box 105 at the front end of the reagent strip translation table 101.
In addition, a pressing rod 315 extending downwards and a membrane pricking head 316 for pricking an aluminum membrane on the reagent strip 103 are mounted on the head withdrawing plate 311; a pressure spring 317 is sleeved on the pressure lever 315; and the pressure lever 315 is positioned above the reagent strip holder 102; when the film binding head 316 withdraws after the aluminum film on the reagent strip 103 is punctured, the pressure lever 315 presses the reagent strip holder 102 to prevent the film binding head 316 from lifting the reagent strip 103.
The reagent on the reagent strip 103 contains magnetic beads, and the magnetic beads are added in the reaction process, so that the magnetic beads can be used for adsorbing and screening substances to be detected in the sample; the analyzer is also provided with a magnetic bead separation module 4. As shown in fig. 5, the magnetic bead separation module 4 includes a magnet holder 401, a magnet 402 mounted on the magnet holder 401, and a magnet driving mechanism for driving the magnet holder 401 to move back and forth; the magnet driving mechanism comprises a magnet driving motor 403 arranged on the liquid suction lifting frame 301, and the magnet support 401 moves back and forth under the drive of the magnet driving motor 403 and the cooperation of a linear shaft 404; the magnet holder 401 has a separation chamber 4011 fitted with the suction head 309, and the magnet 402 is located at a lower portion of the separation chamber 4011; after the magnet support 401 moves in place, the liquid suction head 309 enters the separation chamber 4011, and the magnet 402 adsorbs and separates magnetic beads in the liquid suction head 309 to realize a magnetic bead screening process.
As shown in fig. 6 and 8, the detection module 5 includes a detection assembly and a detection moving mechanism, the detection moving mechanism drives the detection assembly to move left and right, and the detection assembly performs a luminescence test on the reaction substance on the reagent strip. The specific detection moving mechanism comprises a transverse driving motor 501, a transverse moving sliding rail 502 and a transverse moving sliding table 503 in sliding fit with the transverse moving sliding rail 502, a detection assembly is mounted on the transverse moving sliding table 503, and the transverse driving motor 501 drives the detection assembly to move left and right along the transverse moving sliding rail 502 through a synchronous belt transmission mechanism. The detection assembly comprises a photomultiplier 504, an optical fiber 505, a light blocking shutter 506, a shutter cabin body 507 and a rotary electromagnet 508, wherein the light blocking shutter 506 is installed on the shutter cabin body 507, a shutter cabin cover 509 is covered on the shutter cabin body 507, light holes are formed in the light blocking shutter 506 and the shutter cabin body 507, the optical fiber 505 is installed below the light holes of the shutter cabin body 507, a light-tight cylinder 510 is installed outside the optical fiber 505, and the light-tight cylinder 510 is fixed on the shutter cabin cover 509; the photomultiplier 504 is arranged above the light hole of the shutter chamber body 507, the light blocking shutter 506 is connected with the rotary electromagnet 508, and the rotary electromagnet 508 drives the light blocking shutter 506 to rotate so as to control the opening and closing of the light hole of the light blocking shutter 506 and further control the on-off of the light path. In addition, the detection hole position of the reagent strip 103 is a groove-shaped multi-step sealing structure, and is matched with the optical fiber 505, so that the interference of external environment light can be avoided.
As shown in fig. 6 and 7, the detection assembly further includes a shutter opening and closing detection assembly, the shutter opening and closing detection assembly includes an optical coupler baffle 511, a first optical coupler 512, and a second optical coupler 513, the optical coupler baffle 511 is connected to the rotary electromagnet 508, and the optical coupler baffle 511 is provided with a first gap 5111 and a second gap 5112; the first gap 5111 is matched with the first optocoupler 512, and the second gap 5112 is matched with the second optocoupler 513 to detect the opening and closing of the light blocking shutter 506; specifically, when the light blocking shutter 506 is opened, the rotary electromagnet 508 also enables the optical coupler baffle 511 to rotate, a first notch 5111 on the optical coupler baffle 511 is staggered with the position of the first optical coupler 512, the first optical coupler 512 blocks light, a second notch 5112 on the optical coupler baffle 512 is correspondingly superposed with the position of the second optical coupler 513, and the second optical coupler 513 does not block light; when the light blocking shutter is closed, the corresponding state of the two gaps on the optical coupler baffle 511 and the positions of the two optical couplers is opposite to that when the light blocking shutter is opened; therefore, whether the light blocking shutter is closed or not when the sample analysis work is not carried out can be detected by utilizing the shutter opening and closing detection assembly, so that the photomultiplier 504 can be ensured to shield external environment light when not working, the influence of the environment light on the photomultiplier 504 is eliminated, and the damage caused by the fact that the photomultiplier is exposed to the environment light for a long time is avoided.
Furthermore, the detection assembly further comprises a lifting and pressing mechanism, the lifting and pressing mechanism comprises a pressing motor 514, a pressing spring seat 515 and a pressing support 516, the pressing motor 514 is connected with the pressing spring seat 515, the pressing spring seat 515 is connected with the pressing support 516, and the pressing support 516 is connected with the shutter chamber body 507. In addition, the detecting assembly further includes a barcode scanner (not shown in the figure) for scanning a barcode on the reagent strip to correspond the detecting item information on the reagent strip with the reagent strip.
The working principle and the detection process of the multichannel chemical wide immunoassay analyzer of the embodiment are as follows:
the sample adding driving mechanism drives the sampling pump 201 to move to the sampling head frame 603, the sampling pump 201 moves downwards, and the sampling head 202 is inserted; the sample adding driving mechanism drives the sampling pump 201 and the sampling head 202 to move to the sample test tube rack 601, the sampling head 202 moves downwards, and the sampling head 202 sucks the sample in the test tube 602 under the action of the sampling pump 201; then, under the driving of the sample adding driving mechanism, the sampling head 202 which sucks the sample moves to the reagent strip translation module 1, and under the action of the sampling pump 201, the sampling head 202 adds the sample to the sample hole position on the reagent strip 103; after sampling, under the driving of the sample-adding driving mechanism, the sampling head 202 moves to the position of the head-removing frame 212 and is positioned below the bayonet 2121 of the head-removing frame 212; the sampling head 202 is lifted by the sample application driving mechanism, and the bayonet 2121 releases the sampling head 202 and drops it into the sampling head waste box 604.
In addition, the sample to be detected can be whole blood, serum or plasma, and the final concentration calculation method of the substance to be detected is different when different samples are detected, so that sample related parameters need to be set during detection. Therefore, before filling the sample, the sampling head 202 is moved to the sample detection slot 110 on the reagent strip platform 101; the sampling head 202 extends into the sample detection slot 110, and the transmitting end circuit board and the receiving end circuit board are matched to analyze signals so as to judge the type of the sample, thereby being convenient for determining related parameters of the sample during detection.
The imbibition lifting motor 302 drives the imbibition component to move downwards through the screw-nut transmission mechanism; the membrane pricking head 316 arranged on the head withdrawing plate 311 in the imbibing component pricks the corresponding aluminum membrane on the reagent strip 103; after the reagent strip translation driving mechanism drives the reagent strip translation stage to move to the right position, a liquid suction cylinder 308 in the liquid suction assembly is inserted into a liquid suction head 309 on the liquid suction head frame 104. Under the driving of the reagent strip translation driving mechanism, the reagent strip translation table 101 continues to move, so that the hole positions on the reagent strips 103 move in place; the liquid suction motor 306 drives the driving plate 307 to move upwards, the driving plate 307 pulls a cylinder rod of the liquid suction cylinder 308 to form air pressure change, so that the suction force of the liquid suction cylinder 308 is formed, and a liquid suction head 309 connected with the liquid suction cylinder 308 is enabled to suck a reagent or a sample on the reagent strip corresponding to a hole position of the reagent strip 103; under the control action of the control module, the reagent strip translation table 101 continues to move so as to move the reaction hole sites of the reagent strips in place; after a liquid suction motor 306 in the liquid suction assembly drives a driving plate 307 to move downwards, a cylinder rod is reset under the action of a reset spring arranged in a liquid suction cylinder 308, so that a liquid suction head 309 releases a sucked reagent or sample to a reaction hole position of a reagent strip 103; according to the above process, the liquid suction head 309 repeatedly performs suction and release actions, and completes the liquid suction process of the reagent in cooperation with the movement of the reagent strip translation stage 101, and the reagent and the sample are uniformly mixed and reacted; after the reaction, the liquid absorption component absorbs the reaction liquid in the reaction hole; the magnet support 401 moves in place under the driving of the magnetic bead driving motor 403, the liquid suction head 309 enters the separation chamber 4011, and the magnet 402 adsorbs and separates the magnetic beads in the liquid suction head 309, so that the magnetic beads on which the substances to be detected are adsorbed on the inner wall of the liquid suction head 309. Then, the liquid suction motor 306, the driving plate 307 and the liquid suction cylinder 308 cooperate to enable the liquid suction head 309 to release the cleaning waste liquid, so that screening and separation are realized; then, the liquid suction head sucks the luminous substrate liquid in the corresponding hole position of the reagent strip; the magnetic bead driving motor drives the magnet to exit, the luminescent substrate liquid is mixed with the magnetic bead absorbed with the substance to be detected in the liquid suction head, and the liquid suction head injects the mixture of the substance to be detected and the luminescent substrate into the detection hole of the reagent strip 103. Then, under the driving of the liquid suction motor 306, the driving plate 307 pushes the head withdrawing guide shaft 312 to drive the head withdrawing plate 311 to move downwards, the head withdrawing plate 311 pushes the liquid suction head 309 to withdraw the liquid suction head 309 from the liquid suction cylinder 308, and the liquid suction head falls into the liquid suction head waste box 105 at the front end of the reagent strip translation stage 101.
The reagent strip translation module 1 moves the detection hole position of the reagent strip 103 to the detection module 5; a pressing motor 514 in the lifting pressing mechanism drives an optical fiber 505 to press downwards, the optical fiber 505 is pressed into a detection hole position of the reagent strip 103, a rotary electromagnet 508 drives a light blocking shutter 506 to rotate, so that a light hole in the light blocking shutter 506 is communicated with a light hole in a shutter cabin body 507, light emitted by a substance in the detection hole position of the reagent strip 103 passes through the optical fiber 505 and enters a photomultiplier 504 through the light hole in the light blocking shutter 506, the photomultiplier 504 converts an optical signal into an electric signal, related result data is obtained after the electric signal is processed by a processing system of a control module, and the content of the substance to be detected is analyzed according to the data. The transverse driving motor 501 in the detection moving mechanism drives the detection assembly to move left and right so as to detect the reaction substance in each reagent strip translation module 1.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes performed by the present specification and drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (8)
1. A multi-channel chemiluminescent immunoassay analyzer, comprising:
the reagent strip translation device comprises at least two groups of reagent strip translation modules capable of moving back and forth, wherein each group of reagent strip translation modules comprises a reagent strip translation table, a reagent strip rack and reagent strips are arranged on the reagent strip translation table, the reagent strip rack presses the reagent strips, and a plurality of hole positions are formed in the reagent strips;
the automatic sample adding module comprises a sample adding driving mechanism, a sampling pump and a sampling head connected with the sampling pump; the sampling head sucks a sample under the action of the sampling pump, and the sample adding driving mechanism drives the sampling head to move so as to add the sample into a hole position corresponding to the reagent strip; the automatic sample adding module also comprises a head removing frame, wherein a bayonet is arranged on the head removing frame; the sampling head moves to the bayonet and falls off under the action of the bayonet when rising;
the liquid suction reaction module comprises a liquid suction lifting mechanism, a liquid suction assembly and a liquid suction back head assembly; the imbibition lifting mechanism drives the imbibition component to carry out lifting motion; the liquid suction assembly comprises a liquid suction motor, a driving plate, a liquid suction cylinder and a liquid suction head, the liquid suction motor drives the driving plate to move, and the driving plate acts on a cylinder rod of the liquid suction cylinder to enable the liquid suction head connected with the liquid suction cylinder to suck and release liquid corresponding to a hole position of the reagent strip; the liquid suction head withdrawing assembly comprises a head withdrawing plate and a head withdrawing guide shaft, wherein the head withdrawing plate is provided with a cylinder through hole, a liquid suction cylinder penetrates through the cylinder through hole, and the head withdrawing plate is positioned above the liquid suction head; the lower end of the head withdrawing guide shaft is connected with the head withdrawing plate; under the drive of the liquid suction motor, the driving plate pushes the head withdrawing guide shaft to drive the head withdrawing plate to move downwards, and the head withdrawing plate pushes the liquid suction head to withdraw the liquid suction head; the head withdrawing plate is provided with a membrane pricking head and a pressing rod extending downwards, and the pressing rod is sleeved with a pressure spring; and the pressure lever is positioned above the reagent strip rack; when the membrane pricking head withdraws after pricking the aluminum membrane on the reagent strip, the pressure lever presses the reagent rack;
the detection module comprises a detection assembly and a detection moving mechanism, the detection moving mechanism drives the detection assembly to move left and right, and the detection assembly performs luminescence test on reaction substances on the reagent strip.
2. The multi-channel chemiluminescent immunoassay analyzer of claim 1 wherein the sampling pump is provided with a pressure sensor to detect the level of the sample.
3. The multi-channel chemiluminescent immunoassay analyzer of claim 1, wherein the reagent strip translation stage further comprises a sample detection slot at the front end, the sample detection slot is provided with a transmitting end circuit board and a receiving end circuit board, and after the sampling head for sucking the sample extends into the sample detection slot, the transmitting end circuit board and the receiving end circuit board cooperate to analyze the signal so as to determine the type of the sample.
4. The multi-channel chemiluminescent immunoassay analyzer of claim 1 further comprises a magnetic bead separation module, wherein the magnetic bead separation module comprises a magnet support, a magnet mounted on the magnet support, and a magnet driving mechanism for driving the magnet support to move back and forth; the magnet bracket is provided with a separation cavity matched with the liquid suction head, and the magnet is positioned at the lower part of the separation cavity; after the magnet support moves in place, the liquid suction head enters the separation cavity, and the magnet adsorbs and separates magnetic beads in the liquid suction head.
5. The multi-channel chemiluminescent immunoassay analyzer of claim 1 further comprising a sample tube rack, a sampling head rack, a liquid suction head rack, a sampling head waste box and a liquid suction head waste box, wherein the sample tube rack and the sampling head rack are positioned on the left side of the reagent strip translation module, the sampling head waste box is positioned below the liquid removal rack, and the liquid suction head rack and the liquid suction head waste box are positioned at the front end of the reagent strip platform.
6. The multi-channel chemiluminescence immunoassay analyzer according to claim 1, wherein the detection assembly comprises a photomultiplier tube, an optical fiber, a light blocking shutter, a shutter chamber body and a rotary electromagnet, the light blocking shutter is mounted on the shutter chamber body, light transmission holes are formed in the light blocking shutter and the shutter chamber body, the optical fiber is mounted below the light transmission hole in the shutter chamber body, the photomultiplier tube is mounted above the light transmission hole in the shutter chamber body, the light blocking shutter is connected with the rotary electromagnet, and the rotary electromagnet drives the light blocking shutter to rotate so as to control the opening and closing of the light blocking shutter.
7. The multi-channel chemiluminescence immunoassay analyzer according to claim 6, wherein the detection assembly further comprises a shutter opening and closing detection assembly, the shutter opening and closing detection assembly comprises an optical coupling baffle, a first optical coupler and a second optical coupler, the optical coupling baffle is connected with the rotary electromagnet, and a first notch and a second notch are arranged on the optical coupling baffle; the first gap is matched with the first optocoupler, and the second gap is matched with the second optocoupler so as to detect the opening and closing of the light blocking shutter.
8. The multi-channel chemiluminescent immunoassay analyzer of claim 6, wherein the detection assembly further comprises a lifting and pressing mechanism, the lifting and pressing mechanism comprises a pressing motor, a pressing spring seat and a pressing bracket, the pressing motor is connected with the pressing spring seat, the pressing spring seat is connected with the pressing bracket, and the pressing bracket is connected with the shutter chamber body.
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| CN202111043685.4A CN113670900A (en) | 2021-09-07 | 2021-09-07 | Multichannel chemiluminescence immunoassay analyzer |
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