CN102478519A - POCT (point-of-care testing) specific protein analysis system - Google Patents
POCT (point-of-care testing) specific protein analysis system Download PDFInfo
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- CN102478519A CN102478519A CN2010105590454A CN201010559045A CN102478519A CN 102478519 A CN102478519 A CN 102478519A CN 2010105590454 A CN2010105590454 A CN 2010105590454A CN 201010559045 A CN201010559045 A CN 201010559045A CN 102478519 A CN102478519 A CN 102478519A
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Abstract
The invention relates to a POCT (point-of-care testing) specific protein analysis system, which is clinically applicable to testing of specific proteins and a plurality of biochemical immune items, such as glycated hemoglobin (HbA1c), C-reactive protein (CRP), high-sensitivity C-reactive protein (H-CRP), human chorionic gonadotropin (HCG) and the like. After specimens are manually added into a reaction vessel and single multi-reagent pre-subpackage reaction vessels are combined correctly and placed onto a colorimetric station, the whole process of heating, stirring, hemolysis (if needed), automatic multi-reagent time-sharing addition, reaction curves testing, result value calculation and result value printing is automatically completed by instruments. The POCT specific protein analysis system is small in size and simple in operation, manual operations are reduced greatly, and testing is faster and results are more accurate.
Description
Technical field
The present invention relates to a kind of POCT specific protein analytic system that is applied to clinical department, laboratory and family.
Background technology
POCT (point of care testing) is commonly referred to as real-time test, is a fast-developing in recent years emerging field.The essential characteristic of POCT system is an advantages of small volume, and is easy and simple to handle, fast convenient, can record result data at the scene immediately.The detection of specific protein such as glycosylated hemoglobin, Type B natriuretic peptide, high-sensitive C-reactive protein etc. are effective test items of human chronic disease, common disease, frequently-occurring disease, can realize the early detection of multiple disease and the effective monitoring in the therapeutic process.For many years; Mostly these specific protein projects are on large automatic, instrumentation, to test; Some small-sized automanual specific protein analysers have appearred in the recent period; Its characteristic feature is to need auxiliary a large amount of manually-operated, thereby exists the problem that efficient is low, error is big, reagent dosage is big, cost is high, and the reviewer that often need have higher professional skill operates.Be that example is explained the operating process of using this small-sized automanual specific protein analyser with a kind of typical glycosylated hemoglobin testing process below: at first artificial quantitative collection whole blood sample is put into the haemolysis cup; The artificial hemolytic agent mixing that adds; Placed 1-5 minute; Treat that getting quantitative haemolysis sample behind the complete mixing joins in the cuvette; In cuvette, add the 1st reagent by manual work; Add the 2nd reagent again; Mixing; Cuvette was put into the specific protein analyser 5 minutes; Test the 1st absorbance; Take out artificial the 3rd reagent that adds of cuvette; Mixing; Cuvette is put into the specific protein analyser once more; Test the 2nd absorbance after 5 minutes; Report the result and print by automanual specific protein analyser.Above all processes needs 10-15 minute approximately, and the operator will carry out the operation of a step surplus in the of ten therebetween, and the misoperation of any one step or dosage are inaccurate or the time grasp is inaccurate, all can cause the error of test result.
This shows that above-mentioned existing small-sized automanual specific protein analyser obviously still has inconvenience and defective, and demands urgently further improving in structure and use.In order to solve the problem of above-mentioned existence; Relevant manufacturer there's no one who doesn't or isn't seeks solution painstakingly; But do not see always that for a long time suitable design is developed completion, and common product does not have appropriate structure to address the above problem, this obviously is the problem that the anxious desire of relevant dealer solves.The POCT specific protein analytic system of therefore how to found a kind of new structure, real one of the current important research and development problem that belongs to, also becoming the current industry utmost point needs improved target.
Summary of the invention
Fundamental purpose of the present invention is; Overcome defectives such as existing small-sized automanual specific protein analyser operation is loaded down with trivial details, automaticity is low, personal error is big, and a kind of POCT specific protein analytic system of new structure is provided, technical matters to be solved is to make it fully act on the POCT theory; Have that the instrument volume is little, automaticity is high, the simple advantage of operation steps; Thereby greatly reduce manual operation, make the faster result of test more accurate, be very suitable for practicality.
The object of the invention and solve its technical matters and adopt following technical scheme to realize.According to a kind of POCT specific protein analytic system that the present invention proposes, it comprises: at least one many reagent are separately-loaded composite reaction cup in advance, the plurality of reagents that the test of packing in advance is required, and splendid attire test sample book; The integrated positioning heating system of one band heating glass stand is carried described many reagent separately-loaded composite reaction cup in advance, to provide the lasting heating of separately-loaded composite reaction cup in advance of these many reagent; The self-propelled machine of reagent more than one structure is realized the automatic interpolation of plurality of reagents in the separately-loaded composite reaction cup in advance of many reagent; And a transmission scattering combined optical path system, test sample book is carried out transmission and/or two kinds of photometry analyses of scattering.
The object of the invention and solve its technical matters and also can adopt following technical measures further to realize.
Aforesaid POCT specific protein analytic system, wherein said many reagent separately-loaded composite reaction cup in advance are to be combined by socket about honeycomb fashion reagent bottle and the reaction cup; Described honeycomb fashion reagent bottle has more than two the reagent wells position that isolates each other, with can plurality of reagents in advance, and through silica gel plug the reagent wells position is sealed; Described silica gel plug under external force can be along the inwall of corresponding aperture position of the honeycomb fashion reagent bottle of sealing to lower slider, to the reagent pressurization of sealing; The outside in honeycomb fashion reagent bottle bottom face is designed with a micropore jet blower corresponding to each reagent wells position, when the reagent in bottle is under pressure, and can be through corresponding micropore jet blower high velocity jet; Described reaction cup is sheathed on the bottom of honeycomb fashion reagent bottle, and makes the inside of the equal orientating reaction cup of used micropore jet blower on the honeycomb fashion reagent bottle bottom surface, with the splendid attire test sample book, and after adding reagent, supplies sample and reagent to react.
Aforesaid POCT specific protein analytic system; Wherein the bottom in said reaction cup also is provided with one and stirs needle, and under the effect of the rotating magnetic field below the reaction cup, stirring needle can be in the rotation of the bottom of reaction cup; Stir liquid in the cup, make sample and the quick mixing of reagent in the reaction cup; Wherein, described rotating magnetic field is by the stirring motor that is arranged on the base, drives fixingly to stir magnet on it and cause.
Aforesaid POCT specific protein analytic system, the integrated positioning heating system of wherein said band heating glass stand is made up of calandria, heating core and thermistor; Wherein, be provided with spacing equates and isolate each other a plurality of reactions along its length direction, in order to ccontaining a plurality of described many reagent separately-loaded composite reaction cup in advance at the end face of said calandria; Said heating core is a heating rod, is the bottom that is arranged at calandria along the length direction of calandria, each reaction position is provided continue heating equably; Said thermistor is arranged at an end of calandria, with the temperature of perception calandria, the heated condition of calandria is controlled.
Aforesaid POCT specific protein analytic system; Wherein on the sidewall of said calandria one side, also be provided with a beam orifice over against each reaction position; Making transmitted ray through being projected to reaction position, is that length direction along calandria is horizontally disposed with corresponding to all beam orifices of these reaction positions wherein; Each reaction position corresponding to calandria on the sidewall of said this side of calandria also is provided with a scattering hole; Making scattered beam through being projected to reaction position, also is that length direction along calandria is horizontally disposed with corresponding to all scattering holes of these reaction positions wherein; Opposite side at said calandria also is provided with a leadout hole over against each reaction position, to derive the light after transmission or scattering; Described thermistor is to be connected with heating core, through the connecting and disconnecting of this thermistor control heating core circuit, to regulate the temperature of calandria.
Aforesaid POCT specific protein analytic system, wherein said many reagent self-propelled machine structure is made up of support, decelerating step motor, oscillating arm mechanisms and pressure lever mechanism; Wherein, Described support comprises support riser, support upper plate, base plate, cushion block, support left side riser and the right riser of support; The support upper plate is fixed in support left side riser with above the riser of the support right side; The support riser is fixed in the side of support left side riser and the right riser of support, and is fixedly connected with the support upper plate; The right riser of support left side riser and support is fixed in the twice mounting groove of cushion block; Cushion block then is fixed in the fixed orifice of base plate; And constitute a passage by support upper plate, base plate, support left side riser and the right riser of support are common, the integrated positioning heating system that can supply described band to heat glass stand carry described many reagent in advance separately-loaded composite reaction cup pass through; Described decelerating step motor is fixed in the support riser, to drive the oscillating arm mechanisms motion; Described oscillating arm mechanisms comprises first swing arm, second swing arm and the 3rd swing arm, and wherein the center of the 3rd swing arm is connected with the output terminal of decelerating step motor, and its two ends are articulated in the upper end of second swing arm and the 3rd swing arm respectively; And described pressure lever mechanism comprises first group of depression bar and second group of depression bar; Wherein the upper end of first group of depression bar is articulated in the lower end of second swing arm; The upper end of second group of depression bar is articulated in the lower end of the 3rd swing arm; And the lower end of first group of depression bar and second group of depression bar is said many reagent separately-loaded composite reaction cup different reagent wells position of presorting installed reagents in advance of alignment bracket upper plate below respectively, to promote the silica gel plug of position, sealed reagent hole, to reagent pressurization in the bottle.
Aforesaid POCT specific protein analytic system, the first group of wherein said depression bar and the lower end of second group of depression bar are arranged in respectively in the oilless bearing, to guarantee the straight reciprocating motion of described pressure lever mechanism; Described first group of depression bar and second group of depression bar include one or two depression bar; Top at said support riser also is provided with limited post; With when the 3rd swing arm is rotated; Through touching with the two ends of the 3rd swing arm; Limit the motion of first swing arm and second swing arm respectively, can not move upward, and break away from oilless bearing in company with first swing arm and second swing arm to guarantee first group of depression bar and second group of depression bar.
Aforesaid POCT specific protein analytic system; Wherein said transmission scattering combined optical path system comprises transmitted light source and scattering light source; The adjacent side that is arranged at base of transmitted light source and scattering light source wherein, and correspond respectively to transmission through hole and the scattering through hole on the base side wall; At the opposite side of base to should also being provided with a receiver hole by the transmission through hole; One photelectric receiver and preamplification board come from the light after transmission or scattering of receiver hole to should receiver hole being arranged at the opposite side of said base with reception.
Aforesaid POCT specific protein analytic system, wherein said transmitted light source are transmission LED light emitting diode, and it is arranged at an end of light path outer cover through set nut; And the light path outer cover is arranged at a side of said base; And corresponding to the said transmission through hole on the base side wall, be provided with the light hurdle corresponding to an end of transmission through hole, between light hurdle and transmission through hole, be provided with lens at transmission LED light emitting diode; Be provided with the lens back-up ring at the rear of lens, with fixing these lens; Described scattering light source is a scattering LED light emitting diode, and it is arranged in this scattering through hole of sidewall of said base, and is horizontally disposed with this transmission through hole, and to be this transmission through hole be intersected in one with the longitudinal center line level of this scattering through hole compares color bits; Wherein, When the integrated positioning heating system of described band heating glass stand is carried many reagent separately-loaded composite reaction cup is got into light path system and is positioned to test than color bits along the guide rail of said base in advance; Said transmission through hole can be communicated with the beam orifice on the said calandria; Form transmitted light path, the light that transmission LED light emitting diode is sent arrive be positioned at calandria reaction cup; And the scattering through hole can be communicated with the scattering hole on the calandria, forms the scattering light path, and the light that scattering LED light emitting diode is sent arrives this reaction cup; Described photelectric receiver and preamplification board are communicated with leadout hole on the calandria by receiver hole and receive through the transmission of reaction cup or the light after the scattering.
Aforesaid POCT specific protein analytic system, it also comprises a housing, integrated positioning heating system, many reagent self-propelled machine structure and the transmission scattering combined optical path system of above-mentioned band heating glass stand all are arranged in the housing; Wherein, the base of described transmission scattering combined optical path system is arranged on the base plate of many reagent self-propelled machine structure, and makes the colorimetric bit position of transmission scattering combined optical path system be positioned at the pressure lever mechanism below of many reagent self-propelled machine structure; The calandria of the integrated positioning heating system of band heating glass stand can slide along the guide rail of base and debouch this housing; On this housing, also be provided with simultaneously LCDs, operation push-button district, printer, IC-card writable area and test hatch door; Wherein, but display screen display operation menu provides data output demonstration, and the person understands test result with handled easily; The operation push-button district makes the operator can operate and import affirmation, cancellation and the last printout of various command through this regional button to instrument; Printer is used for print result data, control data and chart; The IC-card writable area can read the information of reagent calibration curve, reagent lot number when machine run, so that the operator understands the state of reagent; The test hatch door is opened when calandria stretches out, and closes during withdrawal, to play the lucifuge effect to enclosure interior.
The present invention compared with prior art has tangible advantage and beneficial effect.By technique scheme; POCT specific protein analytic system of the present invention has advantage and beneficial effect at least: the present invention temperature automatically controlledly revises multinomial technology such as calibration curve mechanism with the sample rack of evenly mixing device, single part of preparatory separately-loaded composite reaction of many reagent cup, reagent self-propelled machine structure, IC-card automatically through adopting multistation to have; Realized to have now the robotization of the Overall Steps except that the quantitative collection whole blood sample in the flow process hand-manipulated of complicacy of specific protein check and analysis instrument; Thereby improved work efficiency greatly, reduced artificial cost and the operate miss that takies.Because the present invention can detect by a plurality of stations simultaneously, make detection speed also correspondingly be greatly improved simultaneously.
In sum; The invention relates to a kind of POCT specific protein analytic system; But this system's clinical practice is in measuring specific protein and the immune intermediate item of multiple biochemistry; Like glycosylated hemoglobin (HbA1c), c reactive protein (CRP), high-sensitive C-reactive protein (H-CRP), human chorionic gonadotrophin (HCG) etc.; This system only needs put into than color bits after single part of many reagent are presorted the correct combination of dress composite reaction cup artificial sample is added after the reaction cup, and instrument will be accomplished automatically and heat, the overall process of stirring, haemolysis (like needs), the time-sharing automatic interpolation of many reagent, test reaction curve, result of calculation value and printing.Volume of the present invention is little easy and simple to handle, greatly reduces manual operation, makes the faster result of test more accurate.The present invention has obvious improvement technically, and has tangible good effect, really is the new design of a novelty, progress, practicality.
Above-mentioned explanation only is the general introduction of technical scheme of the present invention; Understand technological means of the present invention in order can more to know; And can implement according to the content of instructions, and for let of the present invention above-mentioned with other purposes, feature and advantage can be more obviously understandable, below special act preferred embodiment; And conjunction with figs., specify as follows.
Description of drawings
Figure 1A is many reagent exploded perspective view of packing composite reaction cup in advance of preferred embodiment of the present invention.
Figure 1B is many reagent synoptic diagram of packing composite reaction cup bottom surface micropore jet blower in advance of preferred embodiment of the present invention.
Fig. 2 is the stereographic map of the band heating glass stand integrated positioning heating system of preferred embodiment of the present invention.
Fig. 3 A is the stereographic map of many reagent self-propelled machine structure of preferred embodiment of the present invention.
Fig. 3 B is the synoptic diagram of support of many reagent self-propelled machine structure of preferred embodiment of the present invention.
Fig. 3 C is the partial sectional view of many reagent self-propelled machine structure of preferred embodiment of the present invention.
Fig. 4 is the synoptic diagram of the transmission scattering combined optical path system of preferred embodiment of the present invention.
Fig. 5 is the stereoscopic figure of the POCT specific protein analytic system of preferred embodiment of the present invention.
Fig. 6 is the face upwarding stereogram of the POCT specific protein analytic system interior section structure of preferred embodiment of the present invention.
1: reagent is separately-loaded composite reaction cup 11 in advance: the honeycomb fashion reagent bottle
12: reaction cup 13: silica gel plug
14: micropore jet blower 2: the integrated positioning heating system of band heating glass stand
21: calandria 22: heating core
23: thermistor 24: the reaction position
25: beam orifice 26: the scattering hole
27: leadout hole 3: many reagent self-propelled machine structure
31: support 311: the support riser
312: support upper plate 313: base plate
314: cushion block 315: support left side riser
316: the right riser 32 of support: decelerating step motor
33: oscillating arm mechanisms swing arm in 331: the first
Swing arm in 332: the second swing arm in 333: the three
342: the second groups of depression bars of 341: the first groups of depression bars
35: optoelectronic switch 36: light barrier
371: oilless bearing 372: the oilless bearing bearing plate
3101,3102: limited post 4: transmission scattering combined optical path system
41: light path outer cover 42: set nut
43: transmission LED light emitting diode 44: light hurdle
45: lens 46: the lens back-up ring
47: support 48: scattering LED light emitting diode
49: base 410: the transmission through hole
411: scattering through hole 412: receiver hole
413: photelectric receiver and preamplification board 414: the comprehensive plate washer of light path
5: housing 51: the liquid crystal display district
52: operation push-button district 53: printer
54:IC card writable area 55: test hatch door
58: control chip 59:IC circuit board support
60: stirring motor 61: stir nested
62: stir magnet
Embodiment
Reach technological means and the effect that predetermined goal of the invention is taked for further setting forth the present invention; Below in conjunction with accompanying drawing and preferred embodiment; To its embodiment of POCT specific protein analytic system, structure, characteristic and the effect thereof that proposes according to the present invention, specify as after.
Relevant aforementioned and other technology contents, characteristics and effect of the present invention can be known to appear in the following detailed description that cooperates with reference to graphic preferred embodiment.Through the explanation of embodiment, when can being to reach technological means that predetermined purpose takes and effect to obtain one more deeply and concrete understanding to the present invention, yet the appended graphic usefulness that only provides reference and explanation be not to be used for the present invention is limited.
A kind of POCT specific protein analytic system according to the preferable enforcement of the present invention is used to measure specific protein and multiple biochemistry, immune project.Mainly integrated positioning heating system 2, many reagent self-propelled machine structure 3, the transmission scattering combined optical path system 4 of separately-loaded composite reaction cup 1, band heating glass stand form in advance by many reagent for they.
See also shown in Figure 1A and Figure 1B, Figure 1A is many reagent exploded perspective view of packing composite reaction cup in advance of preferred embodiment of the present invention.Figure 1B is many reagent synoptic diagram of packing composite reaction cup bottom surface micropore jet blower in advance of preferred embodiment of the present invention.Many reagent of the present invention is separately-loaded composite reaction cup 1 in advance, is in response to demand of the present invention, with the reduction operation easier, and avoids cross pollution, adopts reagent to presort the packing technique manufacturing and forms.Its by honeycomb fashion reagent bottle 11 and reaction cup about in the of 12 socket combine.Wherein, honeycomb fashion reagent bottle 11 has more than two the reagent wells position that isolates each other, and with can plurality of reagents in advance, wherein Figure 1A is to be example with three reagent wells positions, and another one typical structure of the present invention is to have two reagent wells positions arranged side by side.The reagent wells position that pours into behind the reagent utilizes silica gel plug 13 to seal, to guarantee unlikely leakage of reagent and volatilization in transportation and storage process.The inwall of silica gel plug 13 corresponding reagent wells position of the honeycomb fashion reagent bottle 11 of meeting edge sealing under the effect of external force is to lower slider, to the reagent pressurization of sealing.The outside in honeycomb fashion reagent bottle 11 bottom face is designed with a micropore jet blower 14 (as shown in Figure 2) corresponding to each reagent wells position; Because the aperture of micropore jet blower 14 is very little with most advanced and sophisticated sectional area; Therefore the reagent in bottle is under pressure does the time spent; Can be the column injection with higher speed, thereby can reduce the generation of " hang and drip " phenomenon, guarantee the precision that reagent adds.Reaction cup 12 is sheathed on the bottom of honeycomb fashion reagent bottle 11, and makes the inside of the used micropore jet blower 14 orientating reaction cups 12 on honeycomb fashion reagent bottle 11 bottom surfaces.Bottom in reaction cup 12 also is provided with one and stirs needle, under the effect of the rotating magnetic field below the reaction cup 12, stirs needle and can stir liquid in the cup in the rotation of the bottom of reaction cup 12, makes the quick mixing of reactant liquor in the reaction cup 12.And this rotating magnetic field is by the stirring motor 60 that is arranged on the specific protein analytic system base 49 of the present invention, drives fixingly to stir magnet 62 on it and cause (as shown in Figure 6).When the needs mixing, stirring motor 60 starts, rotation, stirs magnet 62 and drives the rotation in reflection cup 12 of stirring needle, the quick mixing of realization response liquid thereupon.
The present invention is through be encapsulated in plurality of reagents in the honeycomb fashion reagent bottle 11 respectively in advance; When operation, only need quantitative sample be joined in the reaction cup 12; Put into the reaction position of specific protein analytic system after again reagent bottle 11 and reaction cup 12 correctly being made up and promptly accomplish manually-operated; POCT specific protein analytic system of the present invention adds required reagent and stirring and evenly mixing with automatic at the appointed time section in test process, therefore can simplify the running program of detection greatly, guarantees the precision of testing result.
Seeing also shown in Figure 2ly, is the stereographic map of the band heating glass stand integrated positioning heating system of preferred embodiment of the present invention.The integrated positioning heating system 2 of band heating glass stand of the present invention is to adopt heating rod to provide as thermal source to continue heating.It is made up of calandria 21, heating core 22 and thermistor 23.Wherein being provided with a plurality of reactions position 24 at the end face of calandria 21 along its length direction, as ccontaining many reagent glass stand of separately-loaded composite reaction cup 1 in advance, wherein is to be example with 4 reaction positions among Fig. 2.Therefore the POCT specific protein analytic system of the present invention sample that can once place a plurality of identical items is simultaneously tested; Also can carry out the combined test of a plurality of disparity items simultaneously, can improve the system effectiveness of specific protein analytic system of the present invention thus greatly and enlarge its range of application.On the sidewall of calandria 21 1 sides, be provided with a beam orifice 25 over against each reaction position 24, its can make transmitted ray through and be projected to the reaction cup 12 that is positioned at this reaction 24.And be that length direction along calandria 21 is horizontally disposed with corresponding to all beam orifices 25 of these reaction positions 24.On the sidewall of calandria 21 these sides, also be provided with a scattering hole 26 simultaneously corresponding to each reaction position 24; So that scattered beam is through being projected to the reaction cup 12 that is positioned at reaction position 24, and all scattering holes 26 also are that length direction along calandria 21 is horizontally disposed with.In the present embodiment, are adjacent settings corresponding to same scattering hole 26 of reacting position 24 with beam orifice 25, and scattering hole 26 is positioned at the place ahead (as shown in Figure 2) of this beam orifice 25.Opposite side at calandria 21 also is provided with a leadout hole 27 over against each reaction position 24, and the light after transmission or scattering is derived.Heating core 22 is a heating rod, is the bottom that is arranged at calandria 21 along the length direction of calandria 21, continues heating so that each reaction position 24 is provided.Thermistor 23 is arranged at an end of calandria 21.Thermistor 23 can perception calandria 21 temperature, with the connecting and disconnecting of control heating core 22 circuit, thereby control the heated condition of calandria 21.Wherein thermistor 23 is to be connected (as shown in Figure 6) with a control chip 58, sends instruction through control chip 58 and gives thermistor 23, to regulate the temperature of calandria 21 internal reaction cups 12.The present invention is through carrying out temperature signal collection with the high precision thermosensitive resistor 23 that is arranged on the calandria 21; And the temperature signal that collects passed to the control chip 58 in the master control board; Carry out PID regulating and controlling heating-up temperature, make the temperature of glass stand can be controlled at 37 ℃ ± 0.3 ℃ consistently.
See also shown in Fig. 3 A, Fig. 3 B and Fig. 3 C, Fig. 3 A is the stereographic map of many reagent self-propelled machine structure of preferred embodiment of the present invention.Fig. 3 B is the synoptic diagram of support of many reagent self-propelled machine structure of preferred embodiment of the present invention.Fig. 3 C is the partial sectional view of many reagent self-propelled machine structure of preferred embodiment of the present invention.Many reagent self-propelled machine structure 3 of the present invention mainly is made up of support 31, decelerating step motor 32, oscillating arm mechanisms 33, pressure lever mechanism, and wherein pressure lever mechanism comprises first group of depression bar 341 and second group of depression bar 342.Above-mentioned support 31 comprises support riser 311, support upper plate 312, base plate 313, cushion block 314, support left side riser 315 and the right riser 316 of support.Wherein, support upper plate 312 is fixed in support left side riser 315 with above the right riser 316 of support, and support riser 311 is fixed in the side of support left side riser 315, the right riser 316 of support and support upper plate 312; The right riser 316 of support left side riser 315 and support is fixed in the twice mounting groove interior (shown in Fig. 3 B) of cushion block 314; 314 of cushion blocks are fixed in the fixed orifice of base plate 313.Therefore constituted an integrated positioning heating system 2 that supplies above-mentioned band heating glass stand jointly by support upper plate 312, base plate 313, support left side riser 315 and the right riser 316 of support and carried many reagent passage of passing through of separately-loaded composite reaction cup 1 in advance, made a plurality of reaction cup 12 that are arranged at calandria 21 add reagent successively and test by many reagent self-propelled machine structure 3.Wherein working as calandria 21 is driven by a decelerating step motor (figure does not show); When the guide rail that on base 49, is provided with carries out linear reciprocating motion; An optoelectronic switch washer (not shown) that is provided with on the calandria 21 can carry out calibration of colorimetric bit position and location during through optoelectronic switch 35 at calandria 21.Again because 4 reaction position 24 spacings on the calandria 21 equate that so the rotation step pitch that decelerating step motor can be identical stays in reaction cup 12 than color bits successively, to guarantee reflecting that cup 12 can carry out colorimetric in correct position.
Decelerating step motor 32 is fixed in support riser 311.Oscillating arm mechanisms 33 comprises first swing arm 331, second swing arm 332 and the 3rd swing arm 333, and wherein the center of the 3rd swing arm 333 is connected with the output terminal of decelerating step motor 332, and the upper end of hinged second swing arm 332 and the 3rd swing arm 333 respectively, two ends; The upper end of first group of depression bar 341 of pressure lever mechanism is articulated in the lower end of second swing arm 332; The upper end of second group of depression bar 342 is articulated in the lower end of the 3rd swing arm 333; And the lower end of first group of depression bar 341 and second group of depression bar 342 is arranged in respectively in the space that support left side riser 315 and support right side riser 316 constituted and is arranged in the oilless bearing bearing plate 372 and the oilless bearing 371 between the support upper plate 312 on the support upper plate 312, with the position, honeycomb fashion reagent bottle 11 reagent corresponding hole of alignment bracket upper plate 312 belows.The present invention that is arranged so that through oilless bearing 371 is not needing external lubrication, just can guarantee the straight reciprocating motion of pressure lever mechanism under the non-maintaining condition of targeting part, thereby accomplishes the pressurization to reagent in the reagent bottle.
Also be provided with limited post 3101,3102 on the top of support riser 311; With when the 3rd swing arm 333 is rotated; Through touching, limit the motion of first swing arm 331 and second swing arm 332, thereby guarantee that first group of depression bar 341 and second group of depression bar 342 can not move upward in company with first swing arm 331 and second swing arm 332 with the two ends of the 3rd swing arm 333; And break away from oilless bearing 371, influence the accuracy that reagent adds.
Seeing also shown in Figure 4ly, is the synoptic diagram of the transmission scattering combined optical path system of preferred embodiment of the present invention.Transmission scattering combined optical path of the present invention system 4 can realize transmission, two kinds of Exposure Meterings of scattering, can use use also capable of being combined separately, and all adopt long service life, and the high solid cold light source of centre wavelength precision is as light source.The combined optical path of transmission scattering in the present embodiment system 4 is as light source with the LED light emitting diode; Wherein transmission LED light emitting diode 43 is arranged at an end of light path outer cover 41 through set nut 42; Light path outer cover 41 is arranged at a side of base 49, and corresponding to the transmission through hole 410 on base 49 sidewalls.The corresponding transmission through hole 410 of opposite side at base 49 also is provided with a receiver hole 412.Be provided with light hurdle 44 at transmission LED light emitting diode 43 corresponding to an end of transmission through hole 410, between light hurdle 44 and transmission through hole 410, be provided with lens 45.Lens back-up ring 46 is arranged at the rear of lens 45, with fixed lens 45 in the wings behind light path system mounted lens 45.One scattering LED light emitting diode 48 is arranged on the sidewall of base 49 and closes in the scattering through hole 411 of transmission through hole 410.In this enforcement, scattering through hole 411 is and transmission through hole 410 levels, and transmission through hole 410 is intersected in one with scattering through hole 411 longitudinal center line levels and compares color bits.When the integrated positioning heating system 2 of band heating glass stand carry many reagent in advance separately-loaded composite reaction cup 1 when the guide rail of base 49 gets into light path system 4; Transmission through hole 410 can be communicated with the beam orifice 25 on the calandria 21, and the light that transmission LED light emitting diode 43 is sent arrives reaction cup 12; And scattering through hole 411 also can be communicated with the scattering hole 26 on the calandria 21, and the light that scattering LED light emitting diode 48 is sent arrives reaction cup 12.One photelectric receiver and preamplification board 413 are arranged at the opposite side with respect to the base 49 of transmission LED light emitting diode 43 and scattering LED light emitting diode 48; And corresponding to the receiver hole 412 on base 49 sidewalls, to be communicated with transmission or the scattered beam that receives through after the reaction cup 12 with the leadout hole 27 of calandria 21 by receiver hole 412.The light of transmission LED light emitting diode 43 emissions exposes to reaction cup 12 behind lens 45, transmission through hole 410, beam orifice 25, behind leadout hole 27, receiver hole 412, received by photelectric receiver again; The light of scattering LED light emitting diode 48 emissions exposes to reaction cup 12 behind scattering through hole 411, scattering hole 26, behind leadout hole 27, receiver hole 412, received by photelectric receiver again.Between the sidewall of photelectric receiver and preamplification board 413 and base 49, also be provided with the comprehensive plate washer 414 of a light path in addition, make photelectric receiver and preamplification board 413 and base 49 keep insulation.Opposite side at base 49 also is provided with support 47, carries parts such as decelerating step motor to be used for carrier.
See also Fig. 5 and shown in Figure 6, Fig. 5 is the stereoscopic figure of the POCT specific protein analytic system of preferred embodiment of the present invention.Fig. 6 is the face upwarding stereogram of the POCT specific protein analytic system interior section structure of preferred embodiment of the present invention.Specific protein analytic system of the present invention also comprises a housing 5, and integrated positioning heating system 2, many reagent self-propelled machine structure 3 and the transmission scattering combined optical path system 4 of above-mentioned band heating glass stand all are arranged in the housing 5.Wherein, The base 49 of transmission scattering combined optical path system 4 is arranged on the base plate 313 of many reagent self-propelled machine structure 3; And transmission scattering combined optical path system 4 is between the right riser 316 of support left side riser 315 and support, thereby makes the colorimetric bit position between the pressure lever mechanism and stirring magnet 62 of many reagent self-propelled machine structure 3.The calandria 21 of the integrated positioning heating system 2 of band heating glass stand can debouch housing 5 slidably along the guide rail of base 49.On housing 5, also be provided with LCDs 51, operation push-button district 52, printer 53, IC-card writable area 54 and test hatch door 55.Wherein, but display screen 51 display operation menus provide data output demonstration, and the person understands test result with handled easily.Operation push-button district 52 makes the operator can operate and import affirmation, cancellation and the last printout order of various command through this regional button to instrument.Printer 53 is used for print result data, control data and chart etc.IC-card writable area 54 can read information such as reagent calibration curve, reagent lot number when machine run, so that the operator understands the state of reagent, and specific protein analytic system of the present invention can't true(-)running when detecting less than IC-card.Test hatch door 55 is opened when calandria 21 stretches out, and closes during withdrawal, to play the lucifuge effect to housing 5 inside, prevents that extraneous light from getting into transmission scattering combined optical path system 4 and influencing testing result.
When using POCT specific protein analytic system of the present invention to detect; At first draw quantitative hemolytic agent and put into reaction cup 12; The blood sample of the nameless tip of quantitative collection measured adds in the reaction cup 12 again; Reaction cup 12 and 11 sockets of honeycomb fashion reagent bottle are combined, put into the reaction position 24 of calandria 21.Wherein preset in the honeycomb fashion reagent bottle 11 project to be measured is detected required reagent.Controlling decelerating step motor drive calandria 21 then slides along the guide rail on the base 49; Get in the housing 5; When many reagent when separately-loaded composite reaction cup 1 moves between many reagent self-propelled machine structure 3 and the transmission scattering combined optical path system 4 with calandria 21 in advance; Optoelectronic switch shelves on the calandria 21 carry out colorimetric bit position calibration and location with optoelectronic switch 35 so that many reagent in advance separately-loaded composite reaction cup 1 rest on correct ratio color bits.
Under the control of micro computer internal program; Decelerating step motor 32 turns clockwise; Drive the 3rd swing arm 333 and turn clockwise simultaneously, because hinged first swing arm 331 and second swing arm 332 respectively of the 3rd swing arm 333 two ends, it is downward to drive first swing arm 331; Second swing arm 332 moves upward; First swing arm 331 moves downward and can drive first group of depression bar 341 and press down, make aim at first group of depression bar 341 be positioned at than color bits many reagent in advance the silica gel plug 13 of separately-loaded composite reaction cup 1 in the back that is under pressure along the inwall of the corresponding reagent wells position of honeycomb fashion reagent bottle 11 to lower slider, give reagent pressurization in the bottle; In following bottle of the promotion of pressure reagent by micropore jet blower 14 high velocity jet of correspondence to reaction cup 12, thereby first group reagent of honeycomb fashion reagent bottle 11 is pressed in the reaction cup.When the 3rd swing arm 333 turned clockwise, after itself and second swing arm, 332 links contacted limited post 3101, therefore first swing arm, 331 stop motions can not drive second group of depression bar 342 and continue to move upward, and had guaranteed the accuracy that first group reagent adds.
After first group reagent is pressed in the reaction cup 12; Decelerating step motor 32 can be according to the operation step number that writes down by its counter-rotating of microcomputerized control, and this moment, micro computer began count steps, when the step number of being calculated satisfies and arrive reference position; Micro computer can send order out of service; Stepper motor 32 is out of service, and oscillating arm mechanisms 33 moves to reference position, accomplishes the interpolation process of first group reagent.Wherein first group of depression bar 341 can comprise one or two depression bars, so this process can add 1 or 2 kind of reagent; The reagent that is added can be any of first group reagent that detects of multiple specific protein such as glycosylated hemoglobin, c reactive protein, high-sensitive C-reactive protein, D dimer, microdose urine protein, apolipoprotein, and by concrete test event decision.
Decelerating step motor 32 is under the control of micro computer setting program; Under the time interval of after adding first group reagent, accurately setting; Be rotated counterclockwise, drive the 3rd swing arm 333 and be rotated counterclockwise simultaneously, the 3rd swing arm 333 drives second swing arm 332 and moves downward; Second group of depression bar 342 pressed down; Pass and be arranged at second group of oilless bearing 71 on the depression bar 342, promote honeycomb fashion reagent bottle 11 corresponding to the silica gel plug 13 of second group of depression bar 342 along the inwall of corresponding reagent wells position to lower slider, give reagent pressurization in the bottle; Bottle interior reagent is injected in the reaction cup 12 at a high speed by the micropore jet blower 14 of correspondence, thereby second group reagent of honeycomb fashion reagent bottle 11 is pressed in the reaction cup.In the process that second group of depression bar 342 presses down, the end that the 3rd swing arm 333 connects first swing arm 331 can be rotated counterclockwise thereupon, when it touches limited post 3102, and second swing arm, 332 stop motions, thus make first group of depression bar 341 can not continue to move upward.According to the step number that the decelerating step motor of record is moved, micro computer can be controlled accurately geocoded activity distance of second group of depression bar 342.According to the operation step number of the decelerating step motor 32 that writes down, under the control of micro computer setting program, after second group reagent was pressed in the reaction cup 12, decelerating step motor 32 dextrorotations went to reference position, accomplished the interpolation process of second group reagent.Second group of depression bar 342 can comprise one or two depression bars; So this process can add 1 or 2 kind of reagent, the reagent that is added can be second group reagent of multiple specific proteins such as glycosylated hemoglobin, c reactive protein, high-sensitive C-reactive protein, D dimer, microdose urine protein, apolipoprotein.
First group add with second group reagent after; Start stirring motor 60; Stir magnet 62 rotates thereupon; Can below the reaction cup that is positioned at the colorimetric position 12, form rotating magnetic field, the stirring needle rotation in the drive reaction cup 12 of rotating magnetic field is carried out quick mixing to reagent and sample in the reaction cup 12.After the time interval of setting through micro computer; Utilize the liquid in 4 pairs of reaction cup of transmission scattering combined optical path system 12 to carry out transmission or scattering analysis; And on LCDs 51, show test results automatically, also can accomplish test process simultaneously through printer 53 printing test results' report.
The above only is preferred embodiment of the present invention, is not the present invention is done any pro forma restriction; Though the present invention discloses as above with preferred embodiment; Yet be not in order to limiting the present invention, anyly be familiar with the professional and technical personnel, in not breaking away from technical scheme scope of the present invention; When the technology contents of above-mentioned announcement capable of using is made a little change or is modified to the equivalent embodiment of equivalent variations; In every case be the content that does not break away from technical scheme of the present invention, to any simple modification, equivalent variations and modification that above embodiment did, all still belong in the scope of technical scheme of the present invention according to technical spirit of the present invention.
Claims (10)
1. POCT specific protein analytic system is characterized in that it comprises:
At least one many reagent is separately-loaded composite reaction cup in advance, the plurality of reagents that the test of packing in advance is required, and splendid attire test sample book;
The integrated positioning heating system of one band heating glass stand is carried described many reagent separately-loaded composite reaction cup in advance, to provide the lasting heating of separately-loaded composite reaction cup in advance of these many reagent;
The self-propelled machine of reagent more than one structure is realized the automatic interpolation of plurality of reagents in the separately-loaded composite reaction cup in advance of many reagent; And
One transmission scattering combined optical path system carries out transmission and/or two kinds of photometry analyses of scattering to test sample book.
2. POCT specific protein analytic system according to claim 1, it is characterized in that wherein said many reagent in advance separately-loaded composite reaction cup be by honeycomb fashion reagent bottle and reaction cup up and down socket combine; Described honeycomb fashion reagent bottle has more than two the reagent wells position that isolates each other, with can plurality of reagents in advance, and through silica gel plug the reagent wells position is sealed; Described silica gel plug under external force can be along the inwall of corresponding aperture position of the honeycomb fashion reagent bottle of sealing to lower slider, to the reagent pressurization of sealing; The outside in honeycomb fashion reagent bottle bottom face is designed with a micropore jet blower corresponding to each reagent wells position, when the reagent in bottle is under pressure, and can be through corresponding micropore jet blower high velocity jet; Described reaction cup is sheathed on the bottom of honeycomb fashion reagent bottle, and makes the inside of the equal orientating reaction cup of used micropore jet blower on the honeycomb fashion reagent bottle bottom surface, with the splendid attire test sample book, and after adding reagent, supplies sample and reagent to react.
3. POCT specific protein analytic system according to claim 2; It is characterized in that wherein the bottom in said reaction cup also is provided with a stirring needle; Under the effect of the rotating magnetic field below the reaction cup; Stir needle and can stir liquid in the cup, make sample and the quick mixing of reagent in the reaction cup in the rotation of the bottom of reaction cup; Wherein, described rotating magnetic field is by the stirring motor that is arranged on the base, drives fixingly to stir magnet on it and cause.
4. POCT specific protein analytic system according to claim 2 is characterized in that the integrated positioning heating system of wherein said band heating glass stand is made up of calandria, heating core and thermistor; Wherein, be provided with spacing equates and isolate each other a plurality of reactions along its length direction, in order to ccontaining a plurality of described many reagent separately-loaded composite reaction cup in advance at the end face of said calandria; Said heating core is a heating rod, is the bottom that is arranged at calandria along the length direction of calandria, each reaction position is provided continue heating equably; Said thermistor is arranged at an end of calandria, with the temperature of perception calandria, the heated condition of calandria is controlled.
5. POCT specific protein analytic system according to claim 4; It is characterized in that on the sidewall of said calandria one side, also being provided with a beam orifice over against each reaction position; Making transmitted ray through being projected to reaction position, is that length direction along calandria is horizontally disposed with corresponding to all beam orifices of these reaction positions wherein; Each reaction position corresponding to calandria on the sidewall of said this side of calandria also is provided with a scattering hole; Making scattered beam through being projected to reaction position, also is that length direction along calandria is horizontally disposed with corresponding to all scattering holes of these reaction positions wherein; Opposite side at said calandria also is provided with a leadout hole over against each reaction position, to derive the light after transmission or scattering; Described thermistor is to be connected with heating core, through the connecting and disconnecting of this thermistor control heating core circuit, to regulate the temperature of calandria.
6. POCT specific protein analytic system according to claim 5 is characterized in that wherein said many reagent self-propelled machine structure is made up of support, decelerating step motor, oscillating arm mechanisms and pressure lever mechanism; Wherein,
Described support comprises support riser, support upper plate, base plate, cushion block, support left side riser and the right riser of support; The support upper plate is fixed in support left side riser with above the riser of the support right side; The support riser is fixed in the side of support left side riser and the right riser of support, and is fixedly connected with the support upper plate; The right riser of support left side riser and support is fixed in the twice mounting groove of cushion block; Cushion block then is fixed in the fixed orifice of base plate; And constitute a passage by support upper plate, base plate, support left side riser and the right riser of support are common, the integrated positioning heating system that can supply described band to heat glass stand carry described many reagent in advance separately-loaded composite reaction cup pass through;
Described decelerating step motor is fixed in the support riser, to drive the oscillating arm mechanisms motion;
Described oscillating arm mechanisms comprises first swing arm, second swing arm and the 3rd swing arm, and wherein the center of the 3rd swing arm is connected with the output terminal of decelerating step motor, and its two ends are articulated in the upper end of second swing arm and the 3rd swing arm respectively; And
Described pressure lever mechanism comprises first group of depression bar and second group of depression bar; Wherein the upper end of first group of depression bar is articulated in the lower end of second swing arm; The upper end of second group of depression bar is articulated in the lower end of the 3rd swing arm; And the lower end of first group of depression bar and second group of depression bar is said many reagent separately-loaded composite reaction cup different reagent wells position of presorting installed reagents in advance of alignment bracket upper plate below respectively, to promote the silica gel plug of position, sealed reagent hole, to reagent pressurization in the bottle.
7. POCT specific protein analytic system according to claim 6 is characterized in that the lower end of wherein said first group of depression bar and second group of depression bar is arranged in respectively in the oilless bearing, to guarantee the straight reciprocating motion of described pressure lever mechanism; Described first group of depression bar and second group of depression bar include one or two depression bar; Top at said support riser also is provided with limited post; With when the 3rd swing arm is rotated; Through touching with the two ends of the 3rd swing arm; Limit the motion of first swing arm and second swing arm respectively, can not move upward, and break away from oilless bearing in company with first swing arm and second swing arm to guarantee first group of depression bar and second group of depression bar.
8. POCT specific protein analytic system according to claim 6; It is characterized in that wherein said transmission scattering combined optical path system comprises transmitted light source and scattering light source; The adjacent side that is arranged at base of transmitted light source and scattering light source wherein, and correspond respectively to transmission through hole and the scattering through hole on the base side wall; The opposite side of base to should the transmission through hole and this scattering through hole also be provided with a receiver hole; One photelectric receiver and preamplification board come from the light after transmission or scattering of receiver hole to should receiver hole being arranged at the opposite side of said base with reception.
9. POCT specific protein analytic system according to claim 8; It is characterized in that wherein said transmitted light source is a transmission LED light emitting diode; It is arranged at an end of light path outer cover through set nut, and the light path outer cover is arranged at a side of said base, and corresponding to the said transmission through hole on the base side wall; Be provided with the light hurdle at transmission LED light emitting diode corresponding to an end of transmission through hole; Between light hurdle and transmission through hole, be provided with lens, be provided with the lens back-up ring, with fixing these lens at the rear of lens;
Described scattering light source is a scattering LED light emitting diode, and it is arranged in this scattering through hole of sidewall of said base, and is horizontally disposed with this transmission through hole, and to be this transmission through hole be intersected in one with the longitudinal center line level of this scattering through hole compares color bits;
Wherein, When the integrated positioning heating system of described band heating glass stand is carried many reagent separately-loaded composite reaction cup is got into light path system and is positioned to test than color bits along the guide rail of said base in advance; Said transmission through hole can be communicated with the beam orifice on the said calandria; Form transmitted light path, the light that transmission LED light emitting diode is sent arrive be positioned at calandria reaction cup; And the scattering through hole can be communicated with the scattering hole on the calandria, forms the scattering light path, and the light that scattering LED light emitting diode is sent arrives this reaction cup; Described photelectric receiver and preamplification board are communicated with leadout hole on the calandria by receiver hole and receive through the transmission of reaction cup or the light after the scattering.
10. POCT specific protein analytic system according to claim 9; It is characterized in that it also comprises a housing, integrated positioning heating system, many reagent self-propelled machine structure and the transmission scattering combined optical path system of above-mentioned band heating glass stand all are arranged in the housing; Wherein, the base of described transmission scattering combined optical path system is arranged on the base plate of many reagent self-propelled machine structure, and makes the colorimetric bit position of transmission scattering combined optical path system be positioned at the pressure lever mechanism below of many reagent self-propelled machine structure; The calandria of the integrated positioning heating system of band heating glass stand can slide along the guide rail of base and debouch this housing;
On this housing, also be provided with simultaneously LCDs, operation push-button district, printer, IC-card writable area and test hatch door; Wherein, but display screen display operation menu provides data output demonstration, and the person understands test result with handled easily; The operation push-button district makes the operator can operate and import affirmation, cancellation and the last printout of various command through this regional button to instrument; Printer is used for print result data, control data and chart; IC-card is separated the state of reagent; The test hatch door is opened when calandria stretches out, and closes during withdrawal, to play the lucifuge effect to enclosure interior.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102507501A (en) * | 2011-10-28 | 2012-06-20 | 深圳市锦瑞电子有限公司 | Special protein testing method and special protein testing device |
| CN104949942A (en) * | 2014-03-27 | 2015-09-30 | 苏州德沃生物技术有限公司 | POCT (point-of-care testing) special protein analysis system |
| CN107290555A (en) * | 2017-07-14 | 2017-10-24 | 深圳市国赛生物技术有限公司 | A kind of POCT specific proteins analyzer system |
| CN109269998A (en) * | 2018-11-16 | 2019-01-25 | 宁波普瑞柏生物技术股份有限公司 | A kind of light path system and detection device of specific protein analyzer |
| CN111812337A (en) * | 2020-08-24 | 2020-10-23 | 桂林优利特医疗电子有限公司 | System and method for realizing specific protein full-linear range calibration by using single-value calibrator |
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| CN101231234A (en) * | 2008-02-15 | 2008-07-30 | 中国科学院上海微系统与信息技术研究所 | Built-in real time image collection processing system based on numerical treatment module |
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| CN102507501A (en) * | 2011-10-28 | 2012-06-20 | 深圳市锦瑞电子有限公司 | Special protein testing method and special protein testing device |
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| CN104949942A (en) * | 2014-03-27 | 2015-09-30 | 苏州德沃生物技术有限公司 | POCT (point-of-care testing) special protein analysis system |
| CN107290555A (en) * | 2017-07-14 | 2017-10-24 | 深圳市国赛生物技术有限公司 | A kind of POCT specific proteins analyzer system |
| CN107290555B (en) * | 2017-07-14 | 2019-02-01 | 深圳市国赛生物技术有限公司 | A kind of POCT specific protein analyzer system |
| CN109269998A (en) * | 2018-11-16 | 2019-01-25 | 宁波普瑞柏生物技术股份有限公司 | A kind of light path system and detection device of specific protein analyzer |
| CN111812337A (en) * | 2020-08-24 | 2020-10-23 | 桂林优利特医疗电子有限公司 | System and method for realizing specific protein full-linear range calibration by using single-value calibrator |
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