CN214539652U - Sample placing device and immunoassay analyzer - Google Patents

Abstract

The utility model belongs to the medical treatment field of detecting discloses a sample placer and immunoassay appearance. The sample placing device comprises a main body part, wherein a reagent placing chamber and a detection chamber are arranged on the main body part, the reagent placing chamber is isolated from the detection chamber, the detection chamber is provided with a detection opening, and the wall part of the detection chamber is isolated from an external light source. The wall of the detection chamber blocks an external light source, so that the detection precision is improved.

Description

Sample placing device and immunoassay analyzer

Technical Field

The utility model belongs to the medical treatment field of detection, especially a sample placer and immunoassay appearance.

Background

The living standard of people is gradually improved, and the health is also gradually emphasized, so more and more body detection items are developed, for example, a liquid phase luminescence immunoassay analyzer is adopted for clinical examination. The liquid phase luminescence immunoassay instrument has various detection items and can be used for detecting and screening various diseases, but in the existing product, the placing device of the sample is interfered by an external light source during detection, so that the detection effect is easily influenced.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to improve prior art's shortcoming, provide a sample placer and immunoassay appearance, block external light source, improve and detect the precision.

The technical scheme is as follows:

the sample placing device comprises a main body part, wherein a reagent placing chamber and a detection chamber are arranged on the main body part, the reagent placing chamber is isolated from the detection chamber, the detection chamber is provided with a detection opening, and the wall part of the detection chamber is isolated from an external light source.

The detection chamber comprises a detection bottle and a coating sleeve, the coating sleeve covers the side wall of the detection bottle, and the side wall of the detection bottle and/or the coating sleeve is isolated from an external light source.

The coating sleeve is made of at least one of black plastic materials, black rubber or black silica gel materials.

The cladding cover is provided with a clamping groove surrounding the detection bottle for one circle.

The detection bottle is provided with two, the cladding cover covers two detection bottle.

The outer side of the coating sleeve is provided with a limiting column, the main body part is provided with a limiting groove matched with the limiting column, the coating sleeve is installed on the main body part, and the limiting column is matched with the limiting groove for limiting.

The outer side of the coating sleeve is provided with a buckling bulge, the main body part is provided with a buckling groove matched with the buckling bulge, the coating sleeve is arranged on the main body part, and the buckling bulge is clamped on the buckling groove.

The reagent bottle is characterized by further comprising a reagent placing bottle, wherein a first placing hole is formed in the main body piece, and the reagent placing bottle is placed on the first placing hole.

The suction head is characterized by further comprising a movable suction head, wherein a second placing hole is formed in the main body piece, and the movable suction head is placed in the second placing hole.

The main body piece is provided with a sample chamber, and the detection chamber, the reagent placing chamber and the sample chamber are arranged in a row.

The immunoassay analyzer comprises a support frame, a sample conveying assembly, an extraction manipulator and a detection assembly, wherein the sample conveying assembly, the extraction manipulator and the detection assembly are all installed on the support frame, and the sample conveying assembly is provided with a sample placing device.

The utility model provides a technical scheme has following advantage and effect:

the reagent placing chamber is used for placing reagents for reaction, the detection chamber is used for placing samples to be detected, the reagents and the samples are separately placed, when the reagents and the samples need to be detected, the reagents and the samples are all extracted to the detection chamber, and the wall part of the detection chamber is isolated from an external light source, so when the detection assembly detects a sample in the detection chamber through a detection opening, the wall part of the detection chamber is light-tight, the external light source is not easy to interfere with detection, and the detection is more accurate.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles, principles and effects of the invention.

Unless otherwise specified or defined, the same reference numerals in different figures refer to the same or similar features, and different reference numerals may be used for the same or similar features.

Fig. 1 is a schematic view-angle-three-dimensional structure diagram of an immunoassay analyzer according to an embodiment of the present invention;

fig. 2 is a schematic view of a two-dimensional structure of an immunoassay analyzer according to an embodiment of the present invention;

fig. 3 is a structural schematic diagram of a movement state of the sample feeding assembly according to the embodiment of the present invention;

FIG. 4 is a schematic structural diagram of a second motion state of the sample feeding assembly according to the embodiment of the present invention;

fig. 5 is a schematic view of an exploded view of a sample transport assembly according to an embodiment of the present invention;

FIG. 6 is a schematic view of a second exploded view of a sample transport assembly according to an embodiment of the present invention;

fig. 7 is a schematic perspective view of a vibration seat according to an embodiment of the present invention;

FIG. 8 is a schematic sectional view of a vibrating part of a sample feeding assembly according to an embodiment of the present invention;

fig. 9 is an enlarged schematic view of a structure at a in fig. 8 according to an embodiment of the present invention;

fig. 10 is a schematic perspective view of a sample placing device according to an embodiment of the present invention;

fig. 11 is an exploded view of the sample placement device according to the embodiment of the present invention;

fig. 12 is an enlarged schematic view of the structure at B in fig. 11 according to the embodiment of the present invention;

fig. 13 is an exploded view of the extraction robot according to the embodiment of the present invention;

fig. 14 is a structural diagram illustrating a state of the pick-up robot according to the embodiment of the present invention;

fig. 15 is a schematic cross-sectional view of fig. 14 according to an embodiment of the present invention;

fig. 16 is an enlarged schematic structural diagram of a point C in fig. 15 according to an embodiment of the present invention.

Fig. 17 is a schematic structural diagram of a second state of the extraction robot according to the embodiment of the present invention;

fig. 18 is a schematic cross-sectional view of fig. 17 according to an embodiment of the present invention;

fig. 19 is a schematic structural view of the back of the extraction robot according to the embodiment of the present invention;

fig. 20 is a structural diagram illustrating a state of a detecting assembly according to an embodiment of the present invention;

fig. 21 is a back structure diagram of the status of the detecting assembly according to the embodiment of the present invention;

fig. 22 is a structural schematic diagram of a second state of the detecting assembly according to the embodiment of the present invention;

fig. 23 is an enlarged schematic view of the embodiment of the present invention at D in fig. 22;

fig. 24 is a schematic cross-sectional view of a detection part of a detection assembly according to an embodiment of the present invention;

fig. 25 is an enlarged schematic view of the embodiment of the present invention at E in fig. 24;

fig. 26 is an enlarged schematic structural diagram of F in fig. 24 according to an embodiment of the present invention.

Description of reference numerals:

10. a support frame; 11. a sample delivery track;

20. a sample sending component; 21. a sample feeding slide seat; 22. a bearing housing; 221. a rotating bearing; 222. a flange boss; 2221. a convex ring; 23. a bearing seat; 231. a bearing mounting position; 232. a vacancy; 24. a fixed platform; 241. a vibration photoelectric detection switch; 25. an eccentric shaft; 251. a first eccentric section; 252. a second eccentric section; 253. a vibration position detection plate; 26. a bearing seat; 261. carrying out carrying position; 262. a first boss; 2621. a ring groove; 27. a power member; 271. a vibration motor; 272. a vibration transmission mechanism; 2721. a first vibrating pulley; 2722. a second vibrating pulley; 2723. vibrating the drive belt; 28. a vibration seat; 281. a fixed part; 2811. a drive bore; 282. a vibrating section; 2821. a first groove; 283. a vibrating arm; 291. a first sample feeding belt pulley; 292. a second sample feeding belt pulley; 293. a sample feeding transmission belt; 294. a sample sending motor;

30. an extraction manipulator; 31. a mounting frame; 32. lifting the driving group; 321. lifting the driving piece; 3211. a lead screw lifting motor; 322. lifting the driving seat; 3221. a membrane pricking rod; 33. a liquid suction driving unit; 331. a fluid-absorbent driving member; 3311. a liquid suction screw motor; 3312. a liquid suction driving seat; 3313. a blocking block; 332. a liquid absorbing member; 3321. extracting the plug rod; 3322. an aspiration chamber; 33221. a liquid suction chamber; 33222. a liquid suction port; 3323. a pipette; 34. a lifting position detection switch; 35. a liquid suction position detection switch;

40. a detection component; 41. a first detection driving group; 411. a first detection screw motor; 42. a second detection driving group; 421. a second detection motor; 422. detecting a belt group; 43. a bearing plate; 44. a light-shielding driving member; 441. a shading screw motor; 442. a shading driving seat; 45. a visor; 46. a light path guide; 461. a first light source detection port; 462. a second light source detection port; 463. a light source input port; 464. a sample detection port; 465. a light splitting sheet; 4651. a first active surface; 4652. a second active surface; 466. an optical lens; 4671. a first optical filter; 4672. a second optical filter; 468. a sealing element; 469. a joint; 471. a second detection rail; 472. a second detection driving seat; 473. a light source element; 474. a spring; 475. a label detector; 476. a first detection rail; 477. a first detection driving seat; 478. a first photodetector; 479. a second photodetector;

50. a sample placement device; 51. a main body member; 511. a reagent holding chamber; 512. a detection chamber; 5121. detecting the bottle; 51211. detecting the opening; 5122. coating a sleeve; 51221. a clamping groove; 51222. a limiting column; 51223. buckling the bulges; 513. a limiting groove; 514. buckling the groove; 515. a first placing hole; 516. a second placing hole; 517. a sample chamber; 52. a reagent holding bottle; 53. a movable suction head.

Detailed Description

In order to facilitate an understanding of the invention, specific embodiments thereof will be described in more detail below with reference to the accompanying drawings.

Unless specifically stated or otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the case of combining the technical solution of the present invention with realistic scenarios, all technical and scientific terms used herein may also have meanings corresponding to the objects of realizing the technical solution of the present invention.

As used herein, unless otherwise specified or defined, "first" and "second" … are used merely for name differentiation and do not denote any particular quantity or order.

As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items, unless specified or otherwise defined.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; when an element is referred to as being "mounted on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.

In this embodiment, the sample includes a reagent and a sample. Reagents such as reagents for reaction, and samples such as blood samples.

As shown in fig. 1 to 3 and 25, the immunoassay analyzer includes a support frame 10, a sample feeding assembly 20, an extraction manipulator 30 and a detection assembly 40, wherein the sample feeding assembly 20, the extraction manipulator 30 and the detection assembly 40 are all mounted on the support frame 10; the sample feeding assembly 20 comprises a receiving seat 26, a receiving position 261 is arranged on the receiving seat 26, and a sample detection port 464 is arranged on the detection assembly 40; during the inspection, the socket 26 is moved by the sample transfer unit 20, and the socket 26 is respectively transferred to the lower side of the extraction robot 30 and the lower side of the inspection unit 40, and the sample detection port 464 corresponds to the receiving position 261.

The sample feeding assembly 20:

as shown in fig. 1 to 9, the sample feeding assembly 20 includes a sample feeding slide seat 21, a sample feeding motor 294, a first sample feeding belt wheel 291, a second sample feeding belt wheel 292, a sample feeding transmission belt 293, a bearing housing 22, a bearing seat 23, a fixed platform 24, an eccentric shaft 25, a power element 27, a bearing seat 26 and a vibration seat 28.

The support frame 10 is provided with a sample feeding rail 11, and the sample feeding slide seat 21 is in sliding fit with the sample feeding rail 11. Through the sliding fit mode, the sample feeding sliding seat 21 slides along the sample feeding rail 11 on the support frame 10, and the sample feeding rail 11 can be directly arranged on the support frame 10 or can be separately processed and then fixedly arranged on the support frame 10. The sample feeding motor 294 is installed on the supporting frame 10 or the sample feeding rail 11, the first sample feeding belt pulley 291 is installed on an output shaft of the sample feeding motor 294, the second sample feeding belt pulley 292 is installed on the supporting frame 10 or the sample feeding rail 11 along the sample feeding rail 11, the sample feeding transmission belt 293 is installed on the first sample feeding belt pulley 291 and the second sample feeding belt pulley 292, and the sample feeding slide base 21 is fixedly connected with the sample feeding transmission belt 293. In this embodiment, the sample feeding motor 294 is fixedly installed on the sample feeding track 11, and then the sample feeding motor 294 rotates to drive the first sample feeding belt 291 to rotate, so as to draw the sample feeding transmission belt 293 to move, and part of the sample feeding slide carriage 21 is fixed with the sample feeding transmission belt 293, so that when the sample feeding transmission belt 293 moves, the sample feeding slide carriage 21 also moves along with the sample feeding transmission belt 293, that is, the sample feeding slide carriage 21 slides along the sample feeding track 11 under the driving of the sample feeding transmission belt 293.

As shown in fig. 5 to 9, the fixed platform 24 is mounted on the sample feeding assembly 20, the power element 27 is fixedly mounted on the fixed platform 24, the vibration seat 28 is provided with a transmission hole 2811, the eccentric shaft 25 has a first eccentric section 251 and a second eccentric section 252, the first eccentric section 251 is rotatably mounted on the fixed platform 24, the second eccentric section 252 passes through the transmission hole 2811 to be matched with the transmission hole 2811, the power element 27 drives the first eccentric section 251 to rotate, and the second eccentric section 252 drives the vibration seat 28 to vibrate. The power member 27 drives the first eccentric section 251 to rotate, the first eccentric section 251 rotates on the fixed platform 24, at this time, the axis of the first eccentric section 251 is the rotation center, the axis of the second eccentric section 252 is different from the axis of the first eccentric section 251, the rotation center of the second eccentric section 252 is different from the axis of the second eccentric section 252 when rotating, so the second eccentric section 252 generates offset rotation. The second eccentric section 252 cooperates with the drive bore 2811 and the vibration mount 28 produces a vibratory effect upon the offset rotation of the second eccentric section 252.

As shown in fig. 5 and 6, the power member 27 includes a vibration motor 271 and a vibration transmission mechanism 272, and the vibration motor 271 drives the eccentric shaft 25 to rotate through the vibration transmission mechanism 272. The vibration motor 271 provides power to drive the eccentric shaft 25 to rotate through the vibration transmission mechanism 272.

Specifically, as shown in fig. 5 and 6, the vibration transmission mechanism 272 includes a first vibration pulley 2721, a second vibration pulley 2722, and a vibration transmission belt 2723, the first vibration pulley 2721 is installed on the vibration motor 271, the second vibration pulley 2722 is installed on the first eccentric section 251, and the vibration transmission belt 2723 is installed on the first vibration pulley 2721 and the second vibration pulley 2722. The power of the vibration motor 271 is transmitted to the first eccentric section 251 by the vibration transmission belt 2723. Compared with the gear meshing transmission mode, the whole weight of the vibration transmission mechanism 272 can be reduced by adopting a belt transmission mode, the manufacturing cost is more economic, the tightness adjustment is more convenient, and the first vibration belt pulley 2721 and the second vibration belt pulley 2722 are not in rigid contact with the vibration transmission belt 2723, so that the buffer effect is achieved, and the noise problem can be effectively reduced.

As shown in fig. 3 to 5, the vibration base 28 is mounted on the socket 26, the vibration base 28 is fixedly connected to the socket 26, and the transmission hole 2811 is provided in the vibration base 28. The bearing seat 26 is used for placing a sample, so that the reaction of the sample can be accelerated under the vibration of the vibration seat 28, the reaction time is further shortened, and the detection is accelerated; and the reagent is more fully reacted through vibration, which is beneficial to improving the detection accuracy.

As shown in fig. 6 and 7, the vibration seat 28 includes a fixing portion 281 and a vibration portion 282, the transmission hole 2811 is disposed on the vibration portion 282, the fixing portion 281 is mounted on the fixing platform 24, and the fixing portion 281 and the vibration portion 282 are connected by a vibration arm 283; the connection point of the vibrating arm 283 and the fixing part 281 is a first connection point, the connection point of the vibrating arm 283 and the vibrating part 282 is a second connection point, and the connection line of the first connection point and the second connection point is different from the axis of the transmission hole 2811. The fixing portion 281 is mounted on the fixed platform 24 to fix the vibration seat 28, and then the vibrating portion 282 is driven by the second eccentric section 252, since the fixing portion 281 and the vibrating portion 282 are connected by the vibrating arms 283, the fixing portion 281 and the vibrating portion 282 are not fixed and cannot move relative to each other, but the vibrating portion 282 is vibrated by bending the vibrating arms 283 when vibrating. In addition, since the vibrating arms 283 are installed in various ways, but when the vibrating direction is perpendicular to the vibrating arms 283, the vibrating direction may not be able to vibrate, and therefore, the connecting line of the first connecting point and the second connecting point may not be spatially intersected with the axis of the transmission hole 2811.

As shown in fig. 5 to 7, a first groove 2821 is disposed at the top of the vibration seat 28, a first boss 262 matched with the first groove 2821 is disposed at the bottom of the receptacle 26, and the first groove 2821 is clamped with the first boss 262. The clamping fit between the first recess 2821 and the first boss 262 plays a positioning role, and then the nail body presses and holds the vibrating seat 28 and the bearing seat 26, so that the vibrating seat 28 and the bearing seat 26 vibrate as a whole during vibration.

The rotating bearing 221 is installed on the bearing sleeve 22, the second eccentric section 252 passes through the rotating bearing 221 installed on the bearing sleeve 22, and the bearing sleeve 22 passes through the transmission hole 2811. In order to avoid the abrasion of the second eccentric section 252 and the vibration seat 28 during the matching, the bearing sleeve 22 is arranged to contact with the inner wall of the transmission hole 2811, and then the bearing sleeve 22 and the second eccentric section 252 are in rotational matching through the rotating bearing 221, and the abrasion during the rotation can be effectively counteracted through the rotating bearing 221. In some embodiments, the bearing sleeve 22 is attached to the inner wall of the transmission hole 2811, and is not prone to relative displacement. In the present embodiment, two rotation bearings 221 are provided inside the bearing housing 22 for balance.

As shown in fig. 8 and 9, the bearing housing 22 is provided with a flange boss 222, a convex ring 2221 is arranged at the top of the flange boss 222 along the axial direction of the bearing housing 22, an annular groove 2621 matched with the convex ring 2221 is arranged at the bottom of the first boss 262, and the convex ring 2221 and the annular groove 2621 are clamped together. The convex ring 2221 and the annular groove 2621 cooperate to complete a position limitation, and then the flange boss 222 is fixedly connected to the bottom of the first boss 262 through the nail body, so in this embodiment, the bearing housing 22 drives the receptacle 26, and then the receptacle 26 drives the vibration seat 28 to vibrate.

One end of the bearing block 23 is fixedly installed on the fixed platform 24, the bearing block 23 is provided with a bearing installation position 231, a rotating bearing 221 is installed on the bearing installation position 231, and the first eccentric section 251 of the eccentric shaft 25 is matched with the rotating bearing 221 located on the bearing installation position 231. The bearing block 23 is fixed to the fixed platform 24 and then is rotatably engaged with the first eccentric section 251 through the rotating bearing 221, so that the bearing block 23 only plays a supporting role when the first eccentric section 251 is driven to rotate. In order to ensure smooth rotation, the bearing seat 23 is provided with two bearing installation positions 231, and each bearing installation position 231 is provided with one rotating bearing 221.

As shown in fig. 9, a vacant position 232 is provided between the two bearing mounting positions 231, and the power member 27 drives the eccentric shaft 25 through the vacant position 232. Driving the first eccentric section 251 between the two bearing seats 231 ensures that the first eccentric section 251 will wobble less during rotation. Specifically, a second vibrating pulley 2722 is located on the void 232, and a vibrating drive belt 2723 can drive the second vibrating pulley 2722 through this arrangement.

As shown in fig. 8 and 9, a vibration position detection plate 253 is installed on the first eccentric section 251, a vibration photoelectric detection switch 241 is installed on the fixed platform 24, and the vibration position detection plate 253 is matched with the vibration photoelectric detection switch 241. When the first eccentric section 251 rotates, the vibration position detection plate 253 rotates synchronously, in order to ensure that the position can stay at a fixed position after each vibration, the vibration position detection plate 253 blocks the vibration photoelectric detection switch 241 and provides a pulse signal, so when the vibration needs to be stopped, the vibration position detection plate 253 and the vibration photoelectric detection switch 241 cooperate to provide position information, and the vibration seat 28 is ensured to be positioned at the same position as the vibration is started when the vibration is stopped.

The extraction robot 30:

as shown in fig. 13, the extraction robot 30 includes a mounting frame 31, a lifting drive unit 32 and a liquid suction drive unit 33, wherein the lifting drive unit 32 is fixedly mounted on the mounting frame 31, and the mounting frame 31 is fixedly mounted on the support frame 10. The mounting rack 31 can form the extraction manipulator 30 into a module, and the installation and the maintenance are both convenient.

As shown in fig. 13-15, the suction drive assembly 33 is mounted to the moving portion of the lift drive assembly 32. When the sample taking device is used, the liquid absorption driving group 33 is lifted up and down through the movement of the lifting driving group 32, when the socket 26 on the sample sending assembly 20 is not moved below the extraction manipulator 30, the lifting driving group 32 lifts the liquid absorption driving group 33 to be in a high position to avoid blocking the socket 26 from moving, when the socket 26 is moved below the extraction manipulator 30, the lifting driving group 32 drives the liquid absorption driving group 33 to move downwards and approach the socket 26, and then the liquid absorption driving group 33 absorbs the sample on the socket 261. After the sample is sucked, the lifting driving group 32 continues to lift upwards, then the sample sending assembly 20 drives the bearing seat 26, so that the liquid absorption driving group 33 faces to different positions of the bearing position 261, the lifting driving group 32 moves downwards again, the liquid absorption driving group 33 releases the sample, and therefore repeated operation is carried out, different samples can be sucked, and the reaction of the sample is completed.

As shown in fig. 13, the lifting driving group 32 includes a lifting driving member 321 and a lifting driving seat 322, the lifting driving member 321 drives the lifting driving seat 322 to move up and down, and the imbibing driving group 33 is installed on the lifting driving seat 322. The lifting driving member 321 is used to drive the lifting driving seat 322, so that the lifting driving seat 322 drives the liquid suction driving group 33 to move up and down.

Specifically, as shown in fig. 14, the lifting driving member 321 is a lifting screw motor 3211, and the lifting screw motor 3211 is engaged with the lifting driving seat 322. The lifting screw rod motor 3211 is adopted for driving, and the lifting driving seat 322 is driven to move up and down by converting a rotating mode into a moving mode.

As shown in fig. 13 and 14, a barbed film rod 3221 is disposed on the lifting driving group 32, and a direction of the barbed film rod 3221 is the same as a driving direction of the lifting driving group 32. The membrane puncturing rod 3221 is used for puncturing a sealing membrane for encapsulating a sample, and the installation direction of the membrane puncturing rod 3221 is the same as the driving direction of the lifting driving column, so that the sealing membrane can be punctured by ensuring that the membrane puncturing rod 3221 moves downwards.

As shown in fig. 13 to 16, the liquid suction driving unit 33 includes a liquid suction driving member 331 and a liquid suction member 332, the liquid suction member 332 is provided with a liquid suction port 33222, and the liquid suction driving member 331 drives the liquid suction member 332. The liquid sucking drive member 331 drives the liquid sucking member 332 to suck the liquid.

As shown in fig. 15 to 18, the liquid suction driving member 331 includes a liquid suction screw motor 3311 and a liquid suction driving base 3312, and the liquid suction member 332 includes an extraction plunger 3321 and a liquid suction chamber 3322 having a liquid suction cavity 33221; the liquid suction screw motor 3311 is matched with the liquid suction driving seat 3312, and the liquid suction screw motor 3311 and the liquid suction chamber 3322 are fixedly arranged on the lifting driving seat 322; one end of the extraction plunger 3321 is fixedly mounted on the liquid suction driving base 3312, the other end thereof movably extends into a liquid suction cavity 33221 of the liquid suction chamber 3322, and the lower portion of the liquid suction cavity 33221 is provided with the liquid suction port 33222. Imbibition lead screw motor 3311 drives imbibition driver base 3312 and then drives extraction cock stem 3321 motion, extraction cock stem 3321 removes in imbibition chamber 33221 of imbibition room 3322, when extraction cock stem 3321 rebound, make the inside negative pressure that forms of imbibition chamber 33221, imbibition mouth 33222 can be to liquid absorption, when the liquid is discharged to needs, imbibition lead screw motor 3311 drives imbibition driver base 3312 rebound, drive extraction cock stem 3321 rebound promptly, liquid discharge in the imbibition chamber 33221. Adopt this mode to absorb liquid, can control through the rotation of control imbibition lead screw motor 3311 and absorb liquid and discharge liquid, compare in the mode that adopts the pump body, the mechanical type of this scheme sets up more conveniently.

As shown in fig. 13 to 16, the extraction plunger 3321 is provided with three side-by-side elements, the liquid suction chamber 3322 is provided with three liquid suction chambers 33221, and each extraction plunger 3321 is engaged with each liquid suction chamber 33221. The extraction cock stem 3321 is three corresponding with imbibition chamber 33221, and imbibition drive seat 3312 can two collection cock stems of synchro control be used for absorbing liquid promptly, places the sample at every turn and can place group's sample, accomplishes the extraction of multiunit sample under a set of effect of extracting manipulator 30, is favorable to accelerating the speed that detects.

In other embodiments, three pipetting chambers 3322 may be provided with only one said pipetting cavity 33221.

As shown in fig. 16 to 18, a stopper 3313 is installed on the liquid suction driving plate 3312, a liquid suction chamber 3322 is provided at the bottom thereof with a liquid suction tube 3323, the liquid suction tube 3323 communicates with the liquid suction port 33222, the stopper 3313 is positioned below the liquid suction chamber 3322, and the liquid suction tube 3323 passes through the stopper 3313. In practical use, the pipette 3323 is required to be installed, the pipette 3323 has an extension function, the pipette 3323 can be used to install the movable tip 53, and the movable tip 53 is made of a soft material such as rubber material or silicone material, so that the movable tip 53 is actually in the first contact with liquid each time it is used, so that the liquid can only stay on the movable tip 53, and the movable tip 53 is contaminated each time it is used, so that the movable tip 53 needs to be taken out each time it is used, and therefore the blocking block 3313 is provided for taking off the movable tip 53. When the movable suction head 53 needs to be taken down, the liquid suction screw motor 3311 drives the liquid suction driving seat 3312 to move downwards, namely, the blocking block 3313 is driven to move downwards, finally, the blocking block 3313 contacts and is mounted on the movable suction head 53 on the liquid suction pipe 3323, the blocking block 3313 continues to move downwards, the movable suction head 53 is separated from the liquid suction pipe 3323, the movable suction head 53 can be taken down in the process, the extraction plug rod 3321 moves downwards under the action of the liquid suction driving seat 3312, liquid sucked is discharged as much as possible, and the situation of liquid residue is avoided.

As shown in fig. 19, the extraction robot 30 is further provided with a lift position detection switch 34 and a suction position detection switch 35, both of which adopt a photoelectric detection method. The lifting position detection switch 34 is used for detecting the movement position of the lifting driving group 32, preventing the movement from exceeding the position and stopping the driving of the lifting screw rod motor 3211 in time; the liquid suction position detection switch 35 is used for detecting the movement position of the liquid suction driving unit 33, preventing the movement from exceeding the position, and stopping the driving of the liquid suction screw motor 3311 in time.

The detection assembly 40:

as shown in fig. 20 to 26, the detecting assembly 40 includes a first detecting driving group 41, a second detecting guide rail 471, a second detecting driving seat 472, a second detecting driving group 42, a light source 473, a light path guide 46, a first photodetector 478, and a second photodetector 479.

As shown in fig. 20 to 23, the second detection guide rail 471 is fixedly installed on the supporting frame 10, the second detection driving seat 472 is slidably engaged with the second detection guide rail 471, the second detection driving group 42 drives the second detection driving seat 472 to move, and the first detection driving group 41 is installed on the second detection driving seat 472. The second detection driving seat 472 is slidably engaged with the second detection guide rail 471, and the second detection driving seat 472 is driven to slide by the second detection driving group 42, the first detection driving group 41 is installed on the second detection driving seat 472, so that the first detection driving group 41 can move along the second detection guide rail 471, that is, the light path detection member can move on the second detection guide rail 471, and under the condition that the sample feeding assembly 20 is provided with a plurality of groups, the light path guide member 46 can be conveyed to the upper part of the sample feeding assembly 20 at different positions for detecting samples on different sample feeding assemblies 20.

As shown in fig. 20 to 23, the second detection driving set 42 includes a second detection motor 421 and a detection belt set 422, the second detection motor 421 is installed on the second detection rail 471 or the supporting frame 10, the detection belt set 422 is installed along the second detection rail 471, the second detection motor 421 drives the detection belt set 422 to move, and one end of the second detection driving seat 472 is fixedly installed on the detection belt set 422. Under the condition that the transmission distance is long, the second detection driving group 42 adopts a belt conveying mode, so that the volume and the cost can be reduced.

As shown in fig. 21 to 23, a first detection guide 476 is fixedly mounted on the second detection driving seat 472, a first detection driving seat 477 is slidably mounted on the first detection guide 476, and the first detection guide 476 is connected to the first detection driving group 41.

The first detecting driving group 41 includes a first detecting screw motor 411 and a first detecting driving base 477, the first detecting screw motor 411 is mounted on the first detecting guide rail 476, and the first detecting driving base 477 is fixed to the light path guide 46 by a receiving plate 43. The first detection screw motor 411 is adopted to drive the light path guide 46 to move up and down, rotation is converted into movement, occupied space is small, and up-and-down control over the light path guide 46 can be completed by directly controlling the first detection screw motor 411.

During detection, the sample feeding assembly 20 enters below the detection assembly 40, when the sample feeding assembly 20 conveys a sample to the position below the detection assembly 40, the first driving set lifts the light path guide 46, and when the sample is conveyed to the position below the detection assembly 40, the first detection driving set 41 moves the light path guide 46 downwards again for detecting the sample.

As shown in fig. 22 and 23, a spring 474 is provided between the receiving plate 43 and the first detecting driving block 477, so that the receiving plate 43 and the first detecting driving block 477 are elastically connected. The receiving plate 43 serves as a coupling function, and the spring 474 is provided to ensure the elasticity between the receiving plate 43 and the first detection driving seat 477, that is, the elasticity between the optical path guide 46 coupled to the receiving plate 43 and the first detection driving seat 477, so that when the optical path guide 46 moves downward to approach the sample, a pressing contact occurs, and also, the spring back is performed by the elasticity to avoid a hard contact.

As shown in fig. 20 and 23, a label detector 475 is attached to the receiving plate 43, and the detection direction of the label detector 475 is downward. The label detector 475 is used to detect the label of the sample, and does not require manual input of sample information, and therefore, is advantageous in increasing the automatic detection rate.

As shown in fig. 1 and 2 and fig. 20 to 25, the light path guide 46 is provided with a light source input port 463, a first light source detection port 461, a sample detection port 464, and a second light source detection port 462, a light emitting end of the light source element 473 is opposed to the light source input port 463, and the first light source detection port 461 is opposed to the first photodetector 478 in a sensing position. The detection light emitted by the light source 473 enters the light path guide 46 through the light source input port 463, passes through the sample detection port 464 after being guided, and emits to the sample, and the light irradiates on the sample, so that the sample excites fluorescence, and the fluorescence enters the light path guide 46 through the sample detection port 464, and then enters the first photoelectric detector 478 through the first light source detection port 461, and the first photoelectric detector 478 detects the fluorescence for analyzing fluorescence information.

As shown in fig. 25, the second light source detection port 462 is opposite to the second photo detector 479. Most of the detection light emitted from the light source 473 passes through the sample detection port 464, and a small portion of about 1% to 7% of the detection light passes through the second light source detection port 462 and is detected by the second photodetector 479, and the second photodetector 479 detects the change in intensity of the detection light emitted from the light source 473, so as to adjust the fluorescence information detected by the first photodetector 478, thereby avoiding the influence on the detection accuracy of the first photodetector 478 due to the instability of the light source 473.

As shown in fig. 24 and 25, a light splitting sheet 465 is disposed inside the light path guide 46, the light splitting sheet 465 has two first action surfaces 4651 and second action surfaces 4652 facing away from each other, a channel connecting the light source input port 463 and the second light source detection port 462 is a first light path channel, a channel connecting the sample detection port 464 and the first light source detection port 461 is a second light path channel, the first light path channel intersects the second light path channel, the light splitting sheet 465 is installed at an intersection of the first light path channel and the second light path channel, the first action surface 4651 faces the light source input port 463 and the sample detection port 464, and the second action surface 4652 faces the first light source detection port 461 and the second light source detection port 462. The spectroscopic plate 465 can reflect most of the light and then transmit a small part of the light, when the light source 473 emits the detection light, most of the light is reflected to enter the sample detection port 464, and a small part of the detection light transmits the spectroscopic plate 465 to enter the second light source detection port 262 to be detected by the second photodetector 479; and a part of the fluorescence excited by the sample passes through the spectroscopic plate 465 and is detected by the first photodetector 478 via the first light source detection port 461.

The light splitting plate 465 may be a dichroic mirror, and may be configured to transmit the light band of the fluorescence, while most of the detection light is not transmitted.

As shown in fig. 24 and 25, an optical lens 466 is mounted on each of the light source input port 463, the first light source detection port 461, the second light source detection port 462, and the sample detection port 464. A first filter 4671 and a second filter 4672 are respectively installed at the light source input port 463 and the first light source detection port 461. The optical lens 466 has a collecting function, collects the dispersed light and then emits the collected light, so as to enhance the intensity of the light and prevent a part of the scattered light from being absorbed. The detection light emitted by the light source 473 passes through the first optical filter 4671 to filter out non-detection light, so that the wavelength of the emitted detection light is concentrated; similarly, when the fluorescence excited by the sample passes through the second optical filter 4672, the non-fluorescence band is filtered, which is beneficial to improve the detection precision of the first photoelectric detector 478.

As shown in fig. 24 and 25, a sealing member 468 is mounted on the light source input port 463, the first light source detection port 461, and the second light source detection port 462, and a through hole is formed in the middle of the sealing member 468. The sealing member 468 may effectively block the external light source from entering the light path guide 46, and the through holes may ensure that the light inside the light path guide 46 passes through the light source input port 463, the first light source detection port 461, and the second light source detection port 462.

As shown in fig. 24 and 26, a through-center joint 469 is mounted on the sample detection port 464, and the joint 469 protrudes from the light path guide 46. The engagement members 469 extend close to the sample to prevent external light sources from entering the light path guide 46.

As shown in fig. 22 and 25, a light shielding plate 45 is installed between the first light source detection port 461 and the first photodetector 478, the light path guide 46 is installed with a light shielding screw motor 441 and a light shielding driving seat 442, the light shielding driving seat 442 is engaged with the light shielding screw motor 441, the light shielding screw motor 441 is fixed on the light path guide 46, and the light shielding plate 45 is fixed on the light shielding driving seat 442. The shading plate 45 is driven by the shading screw motor 441 to move, so that the first light source detection port 461 is opened and closed. The first photodetector 478, which is an element for detecting fluorescence, is highly sensitive and thus cannot be exposed to light for a long period of time, and is provided with the light shielding plate 45, and the light shielding plate 45 is driven to move by the light shielding screw motor 441. When first photoelectric detector 478 need use, light screen 45 opens first light source detection port 461, and fluorescence can enter first photoelectric detector 478, and when first photoelectric detector 478 need not to use, light screen 45 closes first light source detection port 461, plays the effect of protection first photoelectric detector 478.

Sample placement device 50:

as shown in fig. 10 to 12, a sample placing device 50 is placed on the receiving position 261, the sample placing device 50 includes a main body 51, a reagent placing bottle 52 and a movable suction head 53, the main body 51 is provided with a reagent placing chamber 511 and a detection chamber 512, the reagent placing chamber 511 is isolated from the detection chamber 512, the detection chamber 512 is provided with a detection opening 51211, and the wall of the detection chamber 512 is isolated from an external light source.

The reagent placing chamber 511 is used for placing reagents for reaction, the detection chamber 512 is used for placing samples to be detected, the reagents and the samples are separately placed, when detection is needed, the reagents and the samples are all extracted to the detection chamber 512 through the extraction manipulator 30, and the wall of the detection chamber 512 is isolated from an external light source, so when the detection assembly 40 detects a sample in the detection chamber 512 through the detection opening 51211, the wall of the detection chamber 512 is light-tight, and the detection result is not easily interfered.

As shown in fig. 26, when the socket 26 is located under the detecting component 40, the sample detecting port 464 is opposite to the detecting opening 51211 of the detecting chamber 512, and an external light source is isolated between the sample detecting port 464 and the detecting opening 51211. Specifically, the joint 469 located in the sample detection port 464 aligns with the detection opening 51211, so that an external light source is blocked between the joint 469 and the detection opening 51211, and the detection result is prevented from being influenced by the external light source.

As shown in fig. 11, the detection chamber 512 includes a detection bottle 5121 and a covering sleeve 5122, the covering sleeve 5122 covers the side wall of the detection bottle 5121, and the side wall of the detection bottle 5121 is isolated from an external light source. The detection bottle 5121 is used for containing a sample, and the covering sleeve 5122 can isolate an external light source.

As shown in fig. 11, two detection bottles 5121 are provided, and the covering sleeve 5122 covers the two detection bottles 5121. Two test bottles 5121 can be used for one control group and the other test group, so that the accuracy of the test is improved.

The wrapping sleeve 5122 is made of at least one of black plastic material, black rubber or black silica gel material. The wrapping sleeve 5122 is made of black material, and can block the external light source to complete the function of blocking the external light source, but other materials with different colors that can block the light from passing through can also be used.

In other embodiments, the detection bottle 5121 and the covering sleeve 5122 are jointly isolated from an external light source

As shown in fig. 12 and 24, the cover 5122 is provided with a catching groove 51221 which surrounds the detection bottle 5121 by one turn. The locking groove 51221 is engaged with one end of the engaging member 469, i.e. the engaging member 469 is locked inside the locking groove 51221, so that the engaging member 469 and the locking groove 51221 are not light-tight, and further, due to the elastic force between the light path guide 46 and the first detection driving seat 477, when the engaging member 469 is in contact with the locking groove 51221, the engaging member 469 is pressed by the elastic force, so as to ensure the engaging member 469 and the locking groove 51221 to be in a constant contact state. Therefore, when in use, the whole instrument is not required to be shielded from light, and the sample and the light path guide 46 of the detection assembly 40 are detected in a light shielding state, so that compared with the method of shielding the first detection driving seat 477, the method is beneficial to the miniaturization of the equipment and greatly reduces the manufacturing cost.

As shown in fig. 12, a limiting post 51222 is disposed on an outer side of the covering sleeve 5122, a limiting groove 513 matched with the limiting post 51222 is disposed on the main body 51, the covering sleeve 5122 is mounted on the main body 51, and the limiting post 51222 is matched with the limiting groove 513 for limiting. The position-limiting post 51222 is engaged with the position-limiting groove 513 to ensure that the position of the covering sleeve 5122 is relatively controllable when the covering sleeve is assembled on the main body 51, thereby avoiding the occurrence of reverse assembly.

As shown in fig. 12, a fastening protrusion 51223 is disposed on an outer side of the covering sleeve 5122, a fastening groove 514 matching with the fastening protrusion 51223 is disposed on the main body 51, the covering sleeve 5122 is mounted on the main body 51, and the fastening protrusion 51223 is fastened to the fastening groove 514. The fastening protrusion 51223 is fastened to the fastening groove 514, so that the covering sleeve 5122 and the main body 51 are fixedly connected.

As shown in fig. 11, the main body 51 is provided with a first placing hole 515, and the reagent bottle 52 is placed on the first placing hole 515. Since some reagents have high storage requirements or different access methods, a dedicated reagent bottle 52 is provided, and the reagent bottle 52 is placed on the first placement hole 515 separately. The main body member 51 is provided with a second placing hole 516, and the movable suction head 53 is placed on the second placing hole 516. The movable tips 53 are used for aspirating reagents and samples, and as a disposable, at least one movable tip 53 is provided on each body member 51.

As shown in fig. 10 and 11, a sample chamber 517 is formed in the main body member 51, and the detection chamber 512, the reagent holding chamber 511, and the sample chamber 517 are arranged in a row. The sample chamber 517 is used to place a sample to be tested, such as a blood sample, and then the blood sample is placed in the testing chamber 512 by the extraction robot 30. Wherein the detection chamber 512, the reagent placing chamber 511 and the sample chamber 517 are arranged in a row so as to be always kept in a straight line under the driving of the sample feeding assembly 20, thereby facilitating the extraction by the extraction manipulator 30.

When in use, a sample is placed on the receiving position 261 of the socket 26, the socket 26 is driven by the sample conveying assembly 20, and the sample is conveyed to the lower part of the extraction manipulator 30, and the extraction manipulator 30 is used for extracting the sample, extracting the sample to different positions and carrying out reaction; then, the sample transport unit 20 continues to drive, the susceptor 26 is transported to the lower side of the detection unit 40, the reacted sample on the susceptor 261 is aligned by the sample detection port 464, and optical detection is performed to obtain data. The whole process does not need manual operation, realizes automatic detection, achieves the effect of rapid detection, and can effectively improve the detection efficiency.

Specifically, when the extraction manipulator 30 sucks the sample, the movable tip 53 is first snapped into the pipette 3323, and then the sample is sucked out of the sample chamber 517 by the movable tip 53 and sucked into the detection chamber 512; the extracting robot 30 continues to operate to suck the reagents in the reagent accommodating chamber 511 or the reagent accommodating bottle 52 into the detecting chamber 512, where the reagents are sucked one by one, and finally the sample and the reagents are reacted in the detecting chamber 512. Whether it is a sample or a reagent, there may be an excess amount of the sample or reagent drawn by the extraction robot 30, which is then drawn back to the original placement location by the extraction robot 30. Of course, a cleaning solution for cleaning may be placed on the main body member 51, and the movable tip 53 may be cleaned with the cleaning solution each time a sample or a reagent is aspirated.

As shown in fig. 1, the sample presentation assemblies 20 are provided in three sets, the number of sets provided for the extraction robot 30 is the same as the number of sets provided for the sample presentation assemblies 20, and each set of the extraction robot 30 corresponds to each set of the sample presentation assemblies 20. In order to make the detection quick, so send appearance subassembly 20 and extraction manipulator 30 to be provided with the mode of multiunit, every group send appearance subassembly 20 and every group to extract manipulator 30 and correspond, so when first group send appearance subassembly 20 to carry out optical detection, second group send appearance subassembly 20 can continue to extract the sample reaction under the effect of second group manipulator, so make full use of the time of waiting when detecting, accelerate the speed that detects.

Since the sample transfer unit 20 is driven for linear conveyance, the pick-up robot 30 and the detection unit 40 corresponding to the sample transfer unit 20 are located above the conveyance path of the sample transfer unit 20.

When the drawing description is quoted, the new characteristics are explained; in order to avoid that repeated reference to the drawings results in an insufficiently concise description, the drawings are not referred to one by one in the case of clear description of the already described features.

The above embodiments are intended to be illustrative, and should not be construed as limiting the scope of the invention, and the technical solutions, objects and effects of the present invention are described in full herein.

Three or four detection bottles 5121 can be arranged;

if the sample feeding assembly 20 and the extraction manipulator 30 are provided with two or four groups, etc.;

if the screw motor is adopted, the combination of a common motor and a screw can be adopted.

The above examples are not intended to be exhaustive list of the present invention, and there may be many other embodiments not listed. Any replacement and improvement made on the basis of not violating the conception of the utility model belong to the protection scope of the utility model.

Claims (11)

1. The sample placing device is characterized by comprising a main body part, wherein a reagent placing chamber and a detection chamber are arranged on the main body part, the reagent placing chamber is isolated from the detection chamber, the detection chamber is provided with a detection opening, and the wall part of the detection chamber is isolated from an external light source.

2. The specimen placement device according to claim 1, wherein said detection chamber comprises a detection vial and a sheath covering a sidewall of said detection vial, said sidewall of said detection vial and/or said sheath being shielded from an external light source.

3. The specimen placement device according to claim 2, wherein said sheath is made of at least one of black plastic, black rubber, or black silicone.

4. The specimen placement device according to claim 2, wherein said cover is provided with a detent groove that encircles a circumference of said vial.

5. The specimen placement device according to claim 2, wherein there are two of said test vials, and said overwrap covers both of said test vials.

6. The sample placing device according to claim 2, wherein a limiting post is disposed outside the sheath, a limiting groove matched with the limiting post is disposed on the main body, the sheath is mounted on the main body, and the limiting post is matched with the limiting groove for limiting.

7. The sample placement device according to claim 6, wherein the sheath has a fastening protrusion on an outer side thereof, the main member has a fastening groove matching with the fastening protrusion, the sheath is mounted on the main member, and the fastening protrusion is fastened to the fastening groove.

8. The specimen placement device according to any one of claims 1 to 7, further comprising a reagent placement bottle provided with a first placement hole on the main body member, the reagent placement bottle being placed on the first placement hole.

9. The specimen placement device according to any one of claims 1 to 7, further comprising a movable tip, wherein a second placement hole is provided on the main body member, and the movable tip is placed on the second placement hole.

10. The sample placement device according to any one of claims 1 to 7, wherein a sample chamber is defined in said body member, and said detection chamber, said reagent placement chamber and said sample chamber are arranged in a row.

11. The immunoassay analyzer comprises a support frame, a sample sending component, an extraction manipulator and a detection component, wherein the sample sending component, the extraction manipulator and the detection component are all arranged on the support frame, and the sample sending component is provided with the sample placing device according to any one of claims 1 to 10.

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