CN104777321A - Chemiluminescence immunoassay device - Google Patents
Chemiluminescence immunoassay device Download PDFInfo
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- CN104777321A CN104777321A CN201510181011.9A CN201510181011A CN104777321A CN 104777321 A CN104777321 A CN 104777321A CN 201510181011 A CN201510181011 A CN 201510181011A CN 104777321 A CN104777321 A CN 104777321A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
Abstract
The invention provides a chemiluminescence immunoassay device which comprises a sample supply mechanism, a chemical reaction incubation mechanism, a sample adding mechanism and a luminescence detection mechanism, wherein the sample supply mechanism comprises a plurality of sample tubes, a sample disc, a plurality of reagent tubes and a reagent disc, wherein the sample disc and the reagent disc are respectively in a circular ring shape and can rotate. The chemical reaction incubation mechanism is set to be at constant temperature, and comprises a rotary table, a plurality of reaction discs, a plurality of reaction cups and a driving mechanism, wherein the rotary table is in a circular shape; the plurality of reaction discs are arranged on the rotary table at equal intervals along the circumferential direction of the rotary table; reaction cup containing cavities are respectively arranged along the circumferential directions of the reaction discs at equal intervals; the plurality of reaction cups are respectively arranged along the circumferential directions of the reaction discs at equal intervals; the driving mechanism is connected with the rotary table and the plurality of reaction discs by power, so that the rotary table can rotate, and the reaction discs are driven to make revolution or respectively rotate. The sample adding mechanism comprises a liner movement unit, a sample needle, a reagent needle and a cleaning groove. The luminescence detection mechanism comprises a cleaning needle, a substrate needle, a light insulation cover and a detection head.
Description
Technical field
The present invention relates to a kind of chemiluminescence immunoassay class detection system, particularly relate to a kind of chemiluminescence immune assay device.
Background technology
Chemiluminescence immunoassay technology (CLIA) is the up-to-date immune analysis determination technology grown up after exempting from analysis, fluoroimmunoassay etc. continue radioimmunology analysis, enzyme.Chemiluminescence immune assay is made up of immunoassay and chemiluminescence analysis.Immunoassay system be using chemiluminescent substance or enzyme as label, be directly marked on antigen or antibody, through antigen and antibody response, form Ag-Ab immune complex.Chemiluminescence system is after immune response terminates, add the luminous substrate of oxygenant or enzyme, chemiluminescent substance is after the oxidation of oxygenant, form the intermediate that is in excited state, photon can be launched release energy to get back to stable ground state, luminous intensity can utilize luminous signal surveying instrument to detect, and according to the relation of chemiluminescent labels and luminous intensity, usable criterion opisometer calculates the content of measured object.CLIA have highly sensitive, high specificity, the range of linearity are wide, easy and simple to handle, do not need the features such as very expensive instrument and equipment, range of application is comparatively wide, is widely applied in various fields such as environment, clinical, food, drug tests.
Comparatively early, existing product type is also more, and technology is comparative maturity also, occupies most of market for American-European countries's research starting in this respect.China introduces CLIA technology the nineties in last century, just carries out relevant research work at Individual hospitals and research institute at that time, the main dependence on import of instrument used, the product of domestic not comparative maturity; But it is after entering 21 century, along with CLIA technology obtains applying more and more widely, also more strong to the demand of chemical illumination immunity analysis instrument.Therefore, developing chemical illumination immunity analysis instrument is a very large trend.
But domestic existing chemical illumination immunity analysis instrument part adopts guide tracked feed mechanism, causes the size of analyser larger.Utilize the mixing of reagent in rack pinion realization response cup, have larger noise.And efficiency is low, flux is few.
Summary of the invention
In view of Problems existing in background technology, the object of the present invention is to provide a kind of chemiluminescence immune assay device, its space that can greatly reduce shared by whole chemiluminescence immune assay device another object of the present invention is to provide a kind of chemiluminescence immune assay device, it greatly can improve analysis throughput, greatly increases work efficiency.
Another object of the present invention is to provide a kind of chemiluminescence immune assay device, it can hi-Fix.
To achieve these goals, the invention provides a kind of chemiluminescence immune assay device, it comprises hatches mechanism, sample charging mechanism and luminous testing agency for model machine structure, chemical reaction.
Comprise for model machine structure: multiple sample hose, each sample pipe is used for splendid attire sample to be detected; Sample disc, can rotate in annular, the circumference along sample disc is provided with the host cavity of accommodating sample hose; Multiple Reagent Tube, each Reagent Tube is used for splendid attire reagent; And reagent disc, can rotate in annular, be arranged at inside sample disc concentric, be circumferentially provided with the resettlement section of accommodating Reagent Tube.
It is constant temperature that chemical reaction hatches organization establishes, comprising: rotating disk, rounded, relative with sample disc and reagent disc; Multiple reaction tray, the circumference along rotating disk is equally spaced arranged on rotating disk, and each reaction tray is circumferentially equally spaced provided with reaction cup container cavity; Multiple reaction cup, the circumference along each reaction tray is equally spaced arranged, and each reaction cup is inserted and is immobilizated in a reaction cup container cavity in a corresponding reaction tray; And driving mechanism, power connects rotating disk and described multiple reaction tray, to make turntable rotation thus drive all reaction tray to revolve round the sun together or make the rotation separately of all reaction tray.
Sample charging mechanism comprises: rectilinear movement unit, is arranged at supplies the sample disc of model machine structure and the top of reagent disc and rotating disk along the direction for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc; Sample pin, power is connected to rectilinear movement unit, can move along the direction linear reciprocation for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc and can move up and down under the driving of rectilinear movement unit, join with pipette samples from the sample hose be contained in sample disc and by sample in the reaction cup being in a reaction tray of load position be in below rectilinear movement unit; Reagent needles, with and sample pin interval regularly power be connected to rectilinear movement unit, can move along the direction linear reciprocation for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc and can move up and down under the driving of rectilinear movement unit, to draw reagent and reagent is joined in the reaction cup being in a reaction tray of load position be in below rectilinear movement unit from the Reagent Tube be contained on reagent disc; And cleaning slot, hatching between mechanism for model machine structure and chemical reaction in the below of rectilinear movement unit, for cleaning completing sample pin that sample adds and completing the reagent needles that reagent adds.
Luminous testing agency comprises: cleaning needle and substrate pin, be arranged at the top of a corresponding reaction tray and set gradually along the mode that the circumference of this reaction tray is aimed at the part in the multiple reaction cup arranged with the circumference in this reaction tray, and can move along the vertical direction respectively, the reaction cup of cleaning needle in the reaction tray to the correspondence of having hatched is cleaned, and the reaction cup that complete cleaning of substrate pin in the reaction tray to the correspondence of having hatched adds substrate; Light shade cover, can in surface level pivotable and can in the vertical direction lifting, correspondence is arranged at the top of cleaning needle and substrate pin, for all reaction cup on cleaning needle and substrate pin and the reaction tray of correspondence of having hatched and this reaction tray being covered; And detection head, to be arranged in light shade cover and luminescence detection is carried out to the reactant added in the reaction cup of substrate.
Wherein,
The sample disc of model machine structure and reagent disc is supplied to relatively rotate, to make the Reagent Tube of the correspondence on the sample hose of the correspondence in sample disc and reagent disc diametrically in line and be positioned at the below of rectilinear movement unit, rectilinear movement unit drives sample pin is linearly moved to the top of sample hose corresponding respectively and Reagent Tube along the direction for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc and aims at corresponding sample hose and Reagent Tube respectively together with reagent needles; Afterwards, rectilinear movement unit drives sample pin and reagent needles move downward simultaneously, with the sample in difference pipette samples pipe and the reagent in Reagent Tube; Rectilinear movement unit drives sample pin and reagent needles move upward afterwards, drive sample pin together with reagent needles to dial movement along for the sample disc of model machine structure and the direction in the common center of circle to the center of circle of rotating disk of reagent disc;
The driving that chemical reaction hatches the driving mechanism of mechanism makes turntable rotation, thus multiple reaction tray is revolved round the sun and make one of them reaction tray arrive rectilinear movement the below of unit and the correspondence reaction cup in this reaction tray be in rectilinear movement unit below and arrive load position;
The sample pin of rectilinear movement unit drives pipette samples and the reagent needles of absorption reagent move along the direction for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc to the top of the reaction cup being in load position, when needs add sample, sample pin reaches the top of the reaction cup of load position, the sample pin of rectilinear movement unit drives pipette samples and the reagent needles of absorption reagent move downward simultaneously afterwards, be in the reaction cup of load position so that the sample in sample pin is joined, when needs reagent adding, reagent needles reaches the top of the reaction cup of load position, the unit drives sample pin that moves linearly afterwards moves downward with the reagent needles drawing reagent simultaneously, be in the reaction cup of load position so that the reagent in reagent needles is joined,
When the reaction cup of the reaction tray being in load position complete sample add with the adding of reagent after, this reaction tray rotation angle, makes another reaction cup of this reaction tray turn to load position;
Complete sample pin that sample adds and complete the reagent needles that reagent adds and move in the opposite direction along with the side for the sample disc of model machine structure and the common center of circle to the center of circle of rotating disk of reagent disc and move to above cleaning slot under the driving of rectilinear movement unit; Afterwards, the unit drives that moves linearly completes sample pin that sample adds and completes the reagent needles that reagent adds and moves downward in cleaning slot, to clean; Complete after cleaning, rectilinear movement unit drives completes clean sample pin and completes clean reagent needles and to move upward return, the sample pin of unit drives return move linearly afterwards together with the reagent needles of return to for the sample disc of model machine structure and reagent disc motion, draws with the sample carried out next time and reagent absorption and adding of adding of reagent and sample is carried out to another reaction cup described in this reaction tray being in load position;
When all reaction cup in the reaction tray being in load position all complete reagent add with the adding of sample after, driving mechanism drives dial rotation angle, to revolve round the sun an angle to make total overall reaction dish, thus this reaction tray is shifted and total overall reaction cup in this reaction tray is in the state of hatching and makes another reaction tray described be in load position and make a reaction cup of another reaction tray described turn to load position, to carry out adding of reagent and adding of sample;
When rotating disk makes total overall reaction dish revolve round the sun, light shade cover pivotable is moved avoid reaction tray when revolving round the sun, after the revolution of total overall reaction dish terminates, each reaction tray reaches assigned position, one of them reaction tray arrives described load position, and reaction cup completes the below that a correspondence reaction tray of hatching arrives the position at light shade cover place, light shade cover pivotable moves down covers this reaction tray, reaction cup is positioned at the below of cleaning needle and substrate pin successively along with the rotation of this reaction tray afterwards, and in this reaction cup, add cleaning fluid and by unnecessary liquid sucking-off along with the rotation cleaning needle of this reaction tray moves down, substrate pin moves down and add substrate in this reaction cup, finally carry out luminescence by detection head to the reactant added in the reaction cup after substrate to detect.
Beneficial effect of the present invention is as follows:
Guide tracked feed mechanism compared to existing technology, supply the sample disc of model machine structure and reagent disc all to adopt annular and adopt chemical reaction to hatch the rotating disk of mechanism, multiple reaction tray on rotating disk can rotation and revolution, greatly reduce the space shared by whole chemiluminescence immune assay device, substantially increase detection flux, owing to hatching on rotating disk, eliminate the setting carrying out separately the process station of hatching of the prior art, thus drastically increase work efficiency.
By adopt rectilinear movement unit, the sample disc of annular and reagent disc, can the reaction tray of rotation and revolution, can hi-Fix be realized.
Accompanying drawing explanation
Fig. 1 is the vertical view according to chemiluminescence immune assay device of the present invention;
Fig. 2 is the stereographic map supplying model machine structure and sample message identification mechanism according to chemiluminescence immune assay device of the present invention;
Fig. 3 is the stereographic map moving mechanism according to chemiluminescence immune assay device of the present invention;
Fig. 4 hatches the cleaning needle of mechanism and luminous testing agency and the stereographic map of substrate pin according to the chemical reaction of chemiluminescence immune assay device of the present invention, wherein for the sake of clarity, shifts out a reaction cup to expose reaction cup container cavity;
Fig. 5 is another angular views of hatching mechanism according to the chemical reaction of chemiluminescence immune assay device of the present invention.
Wherein, description of reference numerals is as follows:
1 to move linearly unit for model machine structure 31
11 sample hose 32 sample pins
12 sample disc 33 reagent needles
121 host cavity 34 cleaning slots
The 13 luminous testing agencies of Reagent Tube 4
14 reagent disc 41 cleaning needles
Pin is washed in 141 resettlement sections 411
15 reaction tray recovery areas 412 clean suction spindle
2 chemical reactions hatch mechanism 42 substrate pin
21 rotating disk 43 light shade covers
211 through hole 44 detection heads
22 reaction tray 5 storing mechanisms
221 reaction cup container cavity 51 reaction tray warehouses
222 grippings hole 23 reaction cup 52 sample hose warehouse
24 driving mechanism 521 holding parts
Mechanism moved by 241 motors 6
242 main drive gear 60 guide rails
243 pinion wheel 61 slide blocks
244 belt pulley 62 large arm
245 belt 63 forearms
246 electromagnetic clutch 64 tweezers
25 connecting link 65 electromagnet
26 cup dolly 7 sample message identification mechanisms
3 sample charging mechanism 71 cameras
72 bracing frames
Embodiment
Describe in detail with reference to the accompanying drawings according to chemiluminescence immune assay device of the present invention.
Referring to figs. 1 through Fig. 5, chemiluminescence immune assay device according to the present invention comprises hatches mechanism 2, sample charging mechanism 3 and luminous testing agency 4 for model machine structure 1, chemical reaction.Comprise for model machine structure 1: multiple sample hose 11, various kinds QC 11 is for splendid attire sample to be detected; Sample disc 12, can rotate in annular, the circumference along sample disc 12 is provided with the host cavity 121 of accommodating sample hose 11; Multiple Reagent Tube 13, each Reagent Tube 13 is for splendid attire reagent; Reagent disc 14, can rotate in annular, be arranged at inside sample disc 12 concentric, be circumferentially provided with the resettlement section 141 of accommodating Reagent Tube 13.Chemical reaction is hatched mechanism 2 and is set to constant temperature and comprises: rotating disk 21, rounded, relative with reagent disc 14 with sample disc 12; Multiple reaction tray 22, the circumference along rotating disk 21 is equally spaced arranged on rotating disk 21, and each reaction tray 22 is circumferentially equally spaced provided with reaction cup container cavity 221; Multiple reaction cup 23, the circumference along each reaction tray 22 is equally spaced arranged, and each reaction cup 23 is inserted and is immobilizated in a reaction cup container cavity 221 in a corresponding reaction tray 22; Driving mechanism 24, power connects rotating disk 21 and described multiple reaction tray 22, rotates thus drive all reaction tray 22 to revolve round the sun together or make the rotation separately of all reaction tray 22 to make rotating disk 21.Sample charging mechanism 3 comprises: rectilinear movement unit 31, is arranged at the top of sample disc 12 and reagent disc 14 and the rotating disk 21 supplying model machine structure 1 along the direction for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14; Sample pin 32, power is connected to rectilinear movement unit 31, can move along the direction linear reciprocation for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14 and can move up and down under the driving of rectilinear movement unit 31, sample be joined in the reaction cup 23 being in a reaction tray 22 of load position be in below rectilinear movement unit 31 with pipette samples from the sample hose 11 be contained in sample disc 12; Reagent needles 33, with and sample pin 32 interval regularly power be connected to the unit 31 that moves linearly, can move along the direction linear reciprocation for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14 and can move up and down under the driving of rectilinear movement unit 31, to draw reagent and reagent is joined in the reaction cup 23 being in a reaction tray 22 of load position be in below rectilinear movement unit 31 from the Reagent Tube 13 be contained on reagent disc 14; And cleaning slot 34, hatching between mechanism 2 for model machine structure 1 and chemical reaction in the below of rectilinear movement unit 31, for cleaning completing sample pin 32 that sample adds and completing the reagent needles 33 that reagent adds.Luminous testing agency 4 comprises: cleaning needle 41 and substrate pin 42, be arranged at the top of a corresponding reaction tray 22 and set gradually along the mode that the circumference of this reaction tray 22 is aimed at the part in the multiple reaction cup 23 arranged with the circumference in this reaction tray 22, and can move along the vertical direction respectively, cleaning needle 41 is for cleaning the reaction cup 23 in the reaction tray 22 of the correspondence of having hatched, and substrate pin 42 is for adding substrate to the reaction cup 23 completing cleaning in the reaction tray 22 of the correspondence of having hatched; Light shade cover 43, can in surface level pivotable and can in the vertical direction lifting, correspondence is arranged at the top of cleaning needle 41 and substrate pin 42, for all reaction cup 23 on cleaning needle 41 and substrate pin 42 and the reaction tray 22 of correspondence of having hatched and this reaction tray 22 being covered; And detection head 44, to be arranged in light shade cover 43 and luminescence detection is carried out to the reactant added in the reaction cup 23 of substrate.Wherein: supply the sample disc 12 of model machine structure 1 and reagent disc 14 to relatively rotate, to make the Reagent Tube 13 of the correspondence on the sample hose 11 of the correspondence in sample disc 12 and reagent disc 14 diametrically in line and be positioned at the below of rectilinear movement unit 31, rectilinear movement unit 31 drives sample pin 32 be linearly moved to the top of sample hose 11 corresponding respectively and Reagent Tube 13 along the direction for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14 and aim at corresponding sample hose 11 and Reagent Tube 13 respectively together with reagent needles 33, afterwards, rectilinear movement unit 31 drives sample pin 32 and reagent needles 33 to move downward simultaneously, with the sample in difference pipette samples pipe 11 and the reagent in Reagent Tube 13, the unit 31 that moves linearly afterwards drives sample pin 32 and reagent needles 33 to move upward, and drives sample pin 32 to move to rotating disk 21 together with reagent needles 33 along for the sample disc 12 of model machine structure 1 with the direction in the common center of circle to the center of circle of rotating disk 21 of reagent disc 14, the driving that chemical reaction hatches the driving mechanism 24 of mechanism 2 makes rotating disk 21 rotate, thus multiple reaction tray 22 is revolved round the sun and make one of them reaction tray 22 arrive rectilinear movement the below of unit 31 and the correspondence reaction cup 23 in this reaction tray 22 be in rectilinear movement unit 31 below and arrive load position, rectilinear movement unit 31 drives the reagent needles 33 of the sample pin 32 of pipette samples and absorption reagent to move along the direction for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14 to the top of the reaction cup 23 being in load position, when needs add sample, sample pin 32 reaches the top of the reaction cup 23 of load position, the unit 31 that moves linearly afterwards drives the reagent needles 33 of the sample pin 32 of pipette samples and absorption reagent to move downward simultaneously, be in the reaction cup 23 of load position so that the sample in sample pin 32 is joined, when needs reagent adding, reagent needles 33 reaches the top of the reaction cup 23 of load position, the unit 31 that moves linearly afterwards drives the reagent needles 33 of sample pin 32 and absorption reagent to move downward simultaneously, be in the reaction cup 23 of load position so that the reagent in reagent needles 33 is joined, when the reaction cup 23 of the reaction tray 22 being in load position complete sample add with the adding of reagent after, an angle is rotated in this reaction tray 22 rotation, makes another reaction cup 23 of this reaction tray 22 turn to load position, complete sample pin 32 that sample adds and complete the reagent needles 33 that reagent adds and move in the opposite direction along with the side for the sample disc 12 of model machine structure 1 and the common center of circle to the center of circle of rotating disk 21 of reagent disc 14 and move to above cleaning slot 34 under the driving of rectilinear movement unit 31, afterwards, the sample pin 32 that the unit 31 that moves linearly has driven sample to add with complete the reagent needles 33 that reagent adds and move downward in cleaning slot 34, to clean, complete after cleaning, rectilinear movement unit 31 has driven clean sample pin 32 and has completed clean reagent needles 33 and to move upward return, the unit 31 that moves linearly afterwards drives the sample pin 32 of return to move to for the sample disc 12 of model machine structure 1 and reagent disc 14 together with the reagent needles 33 of return, draws and reagent absorption and carry out adding of reagent and adding of sample to another reaction cup 23 described in this reaction tray 22 being in load position with the sample carried out next time, when all reaction cup 23 in the reaction tray 22 being in load position all complete reagent add with the adding of sample after, driving mechanism 24 drives rotating disk 21 to rotate an angle, to revolve round the sun an angle to make total overall reaction dish 22, thus this reaction tray 22 is shifted and total overall reaction cup 23 in this reaction tray 22 is in the state of hatching and makes another reaction tray 22 described be in load position and make reaction cup 23 a to load position of another reaction tray 22 described, to carry out adding of reagent and adding of sample, when rotating disk 21 makes total overall reaction dish 22 revolve round the sun, light shade cover 43 pivotable is moved avoid the reaction tray 22 when revolving round the sun, after total overall reaction dish 22 revolution terminates, each reaction tray 22 reaches assigned position, one of them reaction tray 22 arrives described load position, and reaction cup 23 completes the below that a correspondence reaction tray 22 of hatching arrives the position at light shade cover 43 place, light shade cover 43 pivotable moves down covers this reaction tray 22, reaction cup 23 is positioned at the below of cleaning needle 41 and substrate pin 42 successively along with the rotation of this reaction tray 22 afterwards, and in this reaction cup 23, add cleaning fluid and by unnecessary liquid sucking-off along with the rotation cleaning needle 41 of this reaction tray 22 moves down, substrate pin 42 moves down and add substrate in this reaction cup 23, finally carry out luminescence by detection head 44 to the reactant added in the reaction cup after substrate 23 to detect.
What here illustrate is, chemical reaction is hatched mechanism 2 and is set to constant temperature to refer to whole organization establishes of hatching be flat-temperature zone, namely reaction tray 22 and reaction cup 23 are constant temperature, and namely the temperature requirement of constant temperature meets after reaction cup 23 adds sample and reagent and just start to carry out hatching of chemical reaction.Constant temperature can be undertaken by known feed postition.
What here also illustrate is, adding with the addition sequence of sample of reagent is unrestricted, can be to add sample after first adding reagent, also can be add reagent after first adding sample, no matter any order, just rectilinear movement unit 31 adopts different mobile controls just can realize.
Here also illustrate, rectilinear movement unit 31 can adopt any known mechanism.
In one embodiment, can joint rotation for the sample disc 12 of model machine structure 1 and reagent disc 14, the mixing of reagent can be realized by rotating, solve the noise problem utilizing other mechanisms to produce as rack and pinion drive mechanism mixing.
Compared to the guide tracked feed mechanism of prior art, supply the sample disc 12 of model machine structure 1 and reagent disc 14 all to adopt annular and adopt chemical reaction to hatch the rotating disk 21 of mechanism 2, multiple reaction tray 22 on rotating disk 21 can rotation and revolution, greatly reduce the space shared by whole chemiluminescence immune assay device, substantially increase detection flux, owing to hatching on rotating disk 21, eliminate the setting carrying out separately the process station of hatching of the prior art, thus drastically increase work efficiency.
By adopt rectilinear movement unit 31, the sample disc 12 of annular and reagent disc 14, can the reaction tray 22 of rotation and revolution, can hi-Fix be realized.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 1, described chemiluminescence immune assay device also can comprise storing mechanism 5.Storing mechanism 5 comprises: reaction tray warehouse 51, provides the reaction cup 23 in a reaction tray 22 to be used and this reaction tray 22; And sample hose warehouse 52, multiple sample hose 11 to be detected is provided and for accommodated sample draw sample hose 11.In one embodiment, with reference to Fig. 1, reaction tray warehouse 51 and the sample hose warehouse 52 of storing mechanism 5 can be integrated, reaction tray warehouse 51 is the circle corresponding with the size of reaction tray 22, sample hose warehouse 52 is annular and arranges around reaction tray warehouse 51, sample hose warehouse 52 is provided with multiple holding part 521 vertically, for accommodating sample hose 11 to be detected and the sample hose 11 completing sample absorption.
In an embodiment of chemiluminescence immune assay device according to the present invention, see figures.1.and.2, also can comprise for model machine structure 1: reaction tray recovery area 15, be arranged at the centre of sample disc 12 and reagent disc 14, for reclaiming the reaction tray 22 after luminous detection together with all reaction cup 23 in this reaction tray 22.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 1 and Fig. 3, the center of each reaction tray 22 can arrange gripping hole 222; Described chemiluminescence immune assay device also can comprise moves mechanism 6.Move mechanism 6 can comprise: guide rail 60; Slide block 61, forms sliding pair with guide rail 60, can move along the vertical direction; Large arm 62, is articulated in the top of slide block 61 and can rotates in surface level around slide block 61, and extending in the horizontal direction; Forearm 63, one end is pivotally connected to large arm 62 and rotates in surface level around the pivotal point with large arm 62, and extends in the horizontal direction; Tweezers 64, be fixedly installed on forearm 63 the other end and to downward-extension; Electromagnet 65, is fixedly installed on tweezers 64, and when electromagnet 65 is energized, electromagnet 65 adhesive, tweezers 64 end opens, and when electromagnet 65 power-off, electromagnet 65 opens, and tweezers 64 end closes.Wherein: slide block 61 moves upward along guide rail 60 and large arm 62 and forearm 63 move pivotally, and arrives the top completing the luminous reaction tray 22 detected to make tweezers 64; Electromagnet 65 power-off afterwards, electromagnet 65 are opened, tweezers 64 end closes, and slide block 61 moves downward along guide rail 60, complete in the gripping hole 222 of the luminous reaction tray 22 detected to make tweezers 64 end extend into; Afterwards, when electromagnet 65 is energized, electromagnet 65 adhesive, tweezers 64 end opens, and completes the inwall in the gripping hole 222 of the luminous reaction tray 22 detected to make tweezers 64 end clamp; Afterwards, slide block 61 moves upward along guide rail 60, and to take out completing the luminous reaction tray 22 detected from rotating disk 21, large arm 62 and forearm 63 move pivotally to make the reaction tray 22 completing luminous detection of clamping to reach the top of reaction tray recovery area 15; Afterwards, slide block 61 moves downwardly in reaction cup 23 recovery area along guide rail 60, electromagnet 65 power-off, and electromagnet 65 opens, and tweezers 64 end closes, and tweezers 64 end departs from the inwall in the gripping hole 222 having completed the luminous reaction tray 22 detected; Afterwards, slide block 61 moves upward and the pivoting action reposition of large arm 62 and forearm 63 along guide rail 60; Slide block 61 to move downward and large arm 62 and forearm 63 move pivotally, with the top making tweezers 64 arrive the reaction tray 22 to be used of reaction tray warehouse 51 along guide rail 60; Afterwards, electromagnet 65 power-off, electromagnet 65 are opened, tweezers 64 end closes, and slide block 61 moves downward along guide rail 60, to make tweezers 64 end extend in the gripping hole 222 of reaction tray 22 to be used; Afterwards, when electromagnet 65 is energized, electromagnet 65 adhesive, tweezers 64 end opens, with the inwall making tweezers 64 end clamp the gripping hole 222 of reaction tray 22 to be used; Afterwards, slide block 61 moves upward along guide rail 60, and reaction tray 22 to be used to be taken out from reaction tray warehouse 51, large arm 62 and forearm 63 move pivotally to make the reaction tray 22 to be used of clamping to be positioned at the top of the position of reaction tray 22 vacancy shifted; Slide block 61 moves downward the reaction tray 22 to be used of clamping to put to chemical reaction along guide rail 60 hatches on the position of reaction tray 22 vacancy that mechanism 2 has shifted; Electromagnet 65 power-off, electromagnet 65 opens, and tweezers 64 end closes, and tweezers 64 end departs from the inwall in the gripping hole 222 of reaction tray 22 to be used; Afterwards, slide block 61 moves upward and the pivoting action reposition of large arm 62 and forearm 63 along guide rail 60.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 1 and Fig. 3, move mechanism 6 can also sample hose 11 in clamped sample pipe warehouse 52 and transfer to for model machine structure 1 sample disc 12 and/or completing sample hose 11 that sample provides and transferring in sample hose warehouse 52 for model machine structure 1 can also be clamped.
In an embodiment of chemiluminescence immune assay device according to the present invention, see figures.1.and.2, described chemiluminescence immune assay device also can comprise sample message identification mechanism 7.Sample message identification mechanism 7 can comprise: camera 71, be arranged at the side for model machine structure 1, when rotating for the sample disc 12 of model machine structure 1 and reagent disc 14 and make corresponding sample hose 11 rotate and be exposed to the front of camera 71, camera 71 is taken and label information on collected specimens pipe 11.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 2, sample disc 12 can be in the periphery of reagent disc 14, and camera 71 is in the outside of sample disc 12 and the sample hose 11 towards sample disc 12 is arranged.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 2, sample message identification mechanism 7 also can comprise: bracing frame 72, for supporting camera 71.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 5, the rotating disk 21 that chemical reaction hatches mechanism 2 can be provided with multiple through hole 211, and quantity is corresponding with the quantity of reaction tray 22, and each through hole 211 is concentric with a corresponding reaction tray 22; Chemical reaction is hatched mechanism 2 and also can be comprised: multiple connecting link 25, and quantity is corresponding with the quantity of reaction tray 22, and each connecting link 25 is through a corresponding through hole 211 and one end is removably fixedly connected on the bottom of a corresponding reaction tray 22; And multiple cup dolly 26, quantity is corresponding with the quantity of reaction tray 22, and each cup dolly 26 is fixedly connected on the other end of a corresponding connecting link 25; The driving mechanism 24 that chemical reaction hatches mechanism 2 can comprise: motor 241; Main drive gear 242, power is connected to motor 241; Multiple pinion wheel 243, quantity is corresponding with the quantity of reaction tray 22; Multiple belt pulley 244, quantity is corresponding with the quantity of pinion wheel 243, and each belt pulley 244 is coaxially connected to a corresponding pinion wheel 243; Many belts 245, quantity is corresponding with the quantity of belt pulley 244, and each belt 245 correspondence is around on a corresponding belt pulley 244 and a corresponding cup dolly 26; And electromagnetic clutch 246, be fixedly connected with the bottom of rotating disk 21 and for engaging with main drive gear 242 or departing from, depart from main drive gear 242 to make described multiple pinion wheel 243 and engage or engage with main drive gear 242; Wherein: when electromagnetic clutch 246 engages with main drive gear 242, main drive gear 242 departs from described multiple pinion wheel 243 and engages, motor 241 drives rotating disk 21 to rotate, to realize the revolution of all reaction tray 22 on rotating disk 21 via the bottom of main drive gear 242, electromagnetic clutch 246 and rotating disk 21; When electromagnetic clutch 246 departs from main drive gear 242, main drive gear 242 engages with described multiple pinion wheel 243, and motor 241 drives the rotation simultaneously of described multiple reaction tray 22 via the cup dolly 26 of main drive gear 242, described multiple pinion wheel 243, described multiple belt pulley 244 and described many belts 245, described multiple reaction tray 22 and described multiple connecting link 25.In one embodiment, described being removably fixedly connected with can be socket.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 1 and Fig. 4, cleaning needle 41 can comprise: wash pin 411, in reaction cup 23, add cleaning fluid; And cleaning suction spindle 412, by liquid sucking-off unnecessary in reaction cup 23.In one embodiment, with reference to Fig. 1 and Fig. 4, cleaning needle 41 is 5 pairs, substrate pin 42 is 2, and cleans suction spindle 412-and wash pin 411-to wash pin 411-and clean suction spindle 412-and wash pin 411-and clean suction spindle 412-and wash the order that pin 411-cleaning suction spindle 412-washes pin 411-cleaning suction spindle 412-substrate pin 42-substrate pin 42 and arrange.
In an embodiment of chemiluminescence immune assay device according to the present invention, with reference to Fig. 1, Fig. 4, Fig. 5, reaction tray 22 is 4 and circumference along rotating disk 21 is equidistantly arranged.
In an embodiment of chemiluminescence immune assay device according to the present invention, see figures.1.and.2, resettlement section 141 on reagent disc 14 is set to two circles and two resettlement sections 141 enclosed exist two resettlement sections 141 in same radial direction, to deposit two kinds of reagent for detecting a kind of sample along same radial line, for this situation, linear motion unit 31 can drive sample pin 32 pipette samples and reagent needles 33 to draw reagent simultaneously, and sample pin 32 can elevating movement simultaneously with reagent needles 33.After sample pin 32 pipette samples and reagent needles 33 draw reagent, under the driving of linear motion unit 31, sample pin 32 moves to the direction of reaction tray 22 with reagent needles 33 simultaneously, when arrival is in the top of a reaction cup 23 of the reaction tray 22 of load position, by the reciprocating driving of linear motion unit 31, can first add a kind of reagent, add sample again, finally add the second reagent again, certainly be not limited thereto, (such as first sample can be added depending on the addition sequence of concrete condition adjustment reagent and sample, after add two kinds of reagent, also sample is added after first can adding two kinds of reagent).
Claims (10)
1. a chemiluminescence immune assay device, is characterized in that, comprising:
For model machine structure (1), comprising:
Multiple sample hose (11), various kinds QC (11) is for splendid attire sample to be detected;
Sample disc (12), can rotate in annular, the circumference along sample disc (12) is provided with the host cavity (121) of accommodating sample hose (11);
Multiple Reagent Tube (13), each Reagent Tube (13) is for splendid attire reagent; And
Reagent disc (14), can rotate in annular, is arranged at sample disc (12) inner side concentric, is circumferentially provided with the resettlement section (141) of accommodating Reagent Tube (13);
Chemical reaction hatches mechanism (2), is set to constant temperature, comprises:
Rotating disk (21), rounded, relative with reagent disc (14) with sample disc (12);
Multiple reaction tray (22), the circumference along rotating disk (21) is equally spaced arranged on rotating disk (21), and each reaction tray (22) is circumferentially equally spaced provided with reaction cup container cavity (221);
Multiple reaction cup (23), circumference along each reaction tray (22) is equally spaced arranged, and each reaction cup (23) is inserted and is immobilizated in a reaction cup container cavity (221) on a corresponding reaction tray (22); And
Driving mechanism (24), power connects rotating disk (21) and described multiple reaction tray (22), rotates thus drive all reaction tray (22) to revolve round the sun together or make all reaction tray (22) rotation separately to make rotating disk (21);
Sample charging mechanism (3), comprising:
Rectilinear movement unit (31), is arranged at the top of sample disc (12) and reagent disc (14) and the rotating disk (21) supplying model machine structure (1) along the direction for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14);
Sample pin (32), power is connected to rectilinear movement unit (31), can move along the direction linear reciprocation for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14) and can move up and down under the driving of rectilinear movement unit (31), sample joined be in the reaction cup (23) being on a reaction tray (22) of load position of rectilinear movement unit (31) below from pipette samples in the sample hose (11) be contained in sample disc (12),
Reagent needles (33), with and sample pin (32) interval regularly power be connected to the unit (31) that moves linearly, can move along the direction linear reciprocation for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14) and can move up and down under the driving of rectilinear movement unit (31), to be in the reaction cup (23) being on a reaction tray (22) of load position of rectilinear movement unit (31) below from drawing reagent in the Reagent Tube (13) be contained on reagent disc (14) and reagent being joined, and
Cleaning slot (34), be positioned at the below of rectilinear movement unit (31) and be positioned at and hatch between mechanism (2) for model machine structure (1) and chemical reaction, for cleaning completing sample pin (32) that sample adds and completing the reagent needles (33) that reagent adds;
Luminous testing agency (4), comprising:
Cleaning needle (41) and substrate pin (42), be arranged at the top of a corresponding reaction tray (22) and set gradually along the mode that the circumference of this reaction tray (22) is aimed at the part in the multiple reaction cup (23) arranged with the circumference in this reaction tray (22), and can move along the vertical direction respectively, cleaning needle (41) cleans for the reaction cup (23) in the reaction tray (22) to the correspondence of having hatched, substrate pin (42) adds substrate for the reaction cup (23) completing cleaning in the reaction tray (22) to the correspondence of having hatched,
Light shade cover (43), can in surface level pivotable and can in the vertical direction lifting, correspondence is arranged at the top of cleaning needle (41) and substrate pin (42), for all reaction cup (23) on cleaning needle (41) and substrate pin (42) and the reaction tray (22) of correspondence of having hatched and this reaction tray (22) being covered; And
Detection head (44), to be arranged in light shade cover (43) and to carry out luminescence detection to the reactant added in the reaction cup (23) of substrate;
Wherein:
The sample disc (12) of model machine structure (1) and reagent disc (14) is supplied to relatively rotate, with make the Reagent Tube (13) of the correspondence on the sample hose (11) of the correspondence in sample disc (12) and reagent disc (14) diametrically in line and be positioned at rectilinear movement unit (31) below, rectilinear movement unit (31) drives sample pin (32) and reagent needles (33) are linearly moved to the top of sample hose (11) corresponding respectively and Reagent Tube (13) along the direction for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14) together and aim at corresponding sample hose (11) and Reagent Tube (13) respectively, afterwards, rectilinear movement unit (31) drives sample pin (32) and reagent needles (33) to move downward simultaneously, with the sample in difference pipette samples pipe (11) and the reagent in Reagent Tube (13), the unit (31) that moves linearly afterwards drives sample pin (32) and reagent needles (33) to move upward, and drives sample pin (32) and reagent needles (33) to move to rotating disk (21) together along the direction for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14),
The driving that chemical reaction hatches the driving mechanism (24) of mechanism (2) makes rotating disk (21) rotate, thus multiple reaction tray (22) is revolved round the sun and makes one of them reaction tray (22) arrive the below of rectilinear movement unit (31) and correspondence reaction cup (23) in this reaction tray (22) is in the below of rectilinear movement unit (31) and arrives load position;
Rectilinear movement unit (31) drives the reagent needles (33) of the sample pin (32) of pipette samples and absorption reagent to move along the direction for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14) to the top of the reaction cup (23) being in load position, when needs add sample, sample pin (32) reaches the top of the reaction cup (23) of load position, the unit (31) that moves linearly afterwards drives the reagent needles (33) of the sample pin (32) of pipette samples and absorption reagent to move downward simultaneously, with the sample in sample pin (32) is joined be in load position reaction cup (23) in, when needs reagent adding, reagent needles (33) reaches the top of the reaction cup (23) of load position, the unit (31) that moves linearly afterwards drives the reagent needles (33) of sample pin (32) and absorption reagent to move downward simultaneously, with the reagent in reagent needles (33) is joined be in load position reaction cup (23) in,
When the reaction cup (23) of the reaction tray (22) being in load position complete sample add with the adding of reagent after, this reaction tray (22) rotation angle, makes another reaction cup (23) of this reaction tray (22) turn to load position;
Complete sample pin (32) that sample adds and complete the reagent needles (33) that reagent adds and move in the opposite direction along with the side for the sample disc (12) of model machine structure (1) and the common center of circle to the center of circle of rotating disk (21) of reagent disc (14) and move to the top of cleaning slot (34) under the driving of rectilinear movement unit (31), afterwards, move linearly unit (31) the sample pin (32) that driven sample to add and complete the reagent needles (33) that reagent adds and move downward in cleaning slot (34), to clean, complete after cleaning, rectilinear movement unit (31) has driven clean sample pin (32) and has completed clean reagent needles (33) and to have moved upward return, the unit (31) that moves linearly afterwards drives the reagent needles (33) of the sample pin (32) of return and return together to the sample disc (12) and reagent disc (14) motion that supply model machine structure (1), draw and reagent absorption and adding of reagent and adding of sample are carried out to described another reaction cup (23) of this reaction tray (22) being in load position to carry out sample next time,
When all reaction cup (23) in the reaction tray (22) being in load position all complete reagent add with the adding of sample after, driving mechanism (24) drives rotating disk (21) to rotate an angle, to make total overall reaction dish (22) revolution angle, thus this reaction tray (22) is shifted and total overall reaction cup (23) in this reaction tray (22) is in the state of hatching and makes described another reaction tray (22) be in load position and make a reaction cup (23) of described another reaction tray (22) turn to load position, to carry out adding of reagent and adding of sample,
When rotating disk (21) makes total overall reaction dish (22) revolve round the sun, light shade cover (43) pivotable is moved avoid the reaction tray (22) when revolving round the sun, after total overall reaction dish (22) revolution terminates, each reaction tray (22) reaches assigned position, one of them reaction tray (22) arrives described load position, and reaction cup (23) completes the below that a correspondence reaction tray (22) of hatching arrives the position at light shade cover (43) place, light shade cover (43) pivotable moves down covers this reaction tray (22), reaction cup (23) is positioned at the below of cleaning needle (41) and substrate pin (42) successively along with the rotation of this reaction tray (22) afterwards, and along with the rotation of this reaction tray (22), cleaning needle (41) moves down and in this reaction cup (23), adds cleaning fluid and by unnecessary liquid sucking-off, substrate pin (42) moves down and add substrate in this reaction cup (23), finally carry out luminescence by detection head (44) to the reactant added in the reaction cup after substrate (23) to detect.
2. chemiluminescence immune assay device according to claim 1, is characterized in that, described chemiluminescence immune assay device also comprises:
Storing mechanism (5), comprising:
Reaction tray warehouse (51), provides the reaction cup (23) in a reaction tray (22) to be used and this reaction tray (22); And
Sample hose warehouse (52), multiple sample hose to be detected (11) is provided and for accommodated sample draw sample hose (11).
3. chemiluminescence immune assay device according to claim 2, it is characterized in that, reaction tray warehouse (51) and the sample hose warehouse (52) of storing mechanism (5) are integrated, reaction tray warehouse (51) is the circle corresponding with the size of reaction tray (22), sample hose warehouse (52) is annular and arranges around reaction tray warehouse (51), sample hose warehouse (52) is provided with multiple holding part (521) vertically, for accommodate sample hose (11) to be detected and complete sample draw sample hose (11).
4. chemiluminescence immune assay device according to claim 2, is characterized in that, also comprises for model machine structure (1):
Reaction tray recovery area (15), be arranged at the centre of sample disc (12) and reagent disc (14), for reclaiming the reaction tray (22) after luminous detection together with all reaction cup (23) in this reaction tray (22).
5. chemiluminescence immune assay device according to claim 4, is characterized in that,
The center of each reaction tray (22) arranges gripping hole (222);
Described chemiluminescence immune assay device also comprises:
Move mechanism (6), comprising:
Guide rail (60);
Slide block (61), forms sliding pair with guide rail (60), can move along the vertical direction on guide rail (60);
Large arm (62), is articulated in the top of slide block (61) and can rotates in surface level around slide block (61), and extending in the horizontal direction;
Forearm (63), one end is pivotally connected to large arm (62) and rotates in surface level around the pivotal point with large arm (62), and extends in the horizontal direction;
Tweezers (64), be fixedly installed on forearm (63) the other end and to downward-extension;
Electromagnet (65), be fixedly installed on tweezers (64), when electromagnet (65) is energized, electromagnet (65) adhesive, tweezers (64) end opens, when electromagnet (65) power-off, electromagnet (65) opens, and tweezers (64) end closes;
Wherein:
Slide block (61) moves upward along guide rail (60) and large arm (62) and forearm (63) move pivotally, and arrives to make tweezers (64) top having completed the luminous reaction tray (22) detected; Electromagnet (65) power-off afterwards, electromagnet (65) are opened, tweezers (64) end closes, and slide block (61) moves downward along guide rail (60), complete in the gripping hole (222) of the luminous reaction tray (22) detected to make tweezers (64) end extend into; Afterwards, during electromagnet (65) energising, electromagnet (65) adhesive, tweezers (64) end opens, and completes the inwall in the gripping hole (222) of the luminous reaction tray (22) detected to make tweezers (64) end clamp; Afterwards, slide block (61) moves upward along guide rail (60), the reaction tray (22) detected will complete luminescence is taken out from rotating disk (21), and large arm (62) and forearm (63) move pivotally with the top making the reaction tray (22) completing luminous detection of clamping reach reaction tray recovery area (15); Afterwards, slide block (61) moves downwardly in reaction cup (23) recovery area along guide rail (60), electromagnet (65) power-off, electromagnet (65) opens, tweezers (64) end closes, and tweezers (64) end departs from the inwall in the gripping hole (222) having completed the luminous reaction tray (22) detected; Afterwards, slide block (61) moves upward and the pivoting action reposition of large arm (62) and forearm (63) along guide rail (60);
Slide block (61) moves downward and large arm (62) and forearm (63) pivoting action along guide rail (60), with the top making tweezers (64) arrive the reaction tray (22) to be used of reaction tray warehouse (51); Afterwards, electromagnet (65) power-off, electromagnet (65) are opened, tweezers (64) end closes, and slide block (61) moves downward along guide rail (60), to make tweezers (64) end extend in the gripping hole (222) of reaction tray (22) to be used; Afterwards, during electromagnet (65) energising, electromagnet (65) adhesive, tweezers (64) end opens, with the inwall making tweezers (64) end clamp the gripping hole (222) of reaction tray (22) to be used; Afterwards, slide block (61) moves upward along guide rail (60), reaction tray (22) to be used to be taken out from reaction tray warehouse (51), large arm (62) and forearm (63) move pivotally with the top making the reaction tray (22) to be used of clamping be positioned at the position of reaction tray (22) vacancy shifted; Slide block (61) moves downward the reaction tray (22) to be used of clamping to put to chemical reaction along guide rail (60) hatches on the position of reaction tray (22) vacancy that mechanism (2) has shifted; Electromagnet (65) power-off, electromagnet (65) opens, and tweezers (64) end closes, and tweezers (64) end departs from the inwall in the gripping hole (222) of reaction tray (22) to be used; Afterwards, slide block (61) moves upward and the pivoting action reposition of large arm (62) and forearm (63) along guide rail (60).
6. chemiluminescence immune assay device according to claim 5, is characterized in that,
Move mechanism (6) can also sample hose (11) in clamped sample pipe warehouse (52) and transfer to for model machine structure (1) sample disc (12) and/or completing sample hose (11) that sample provides and transferring in sample hose warehouse (52) for model machine structure (1) can also be clamped.
7. chemiluminescence immune assay device according to claim 1, is characterized in that, described chemiluminescence immune assay device also comprises:
Sample message identification mechanism (7), comprising:
Camera (71), be arranged at the side for model machine structure (1), when rotating for the sample disc (12) of model machine structure (1) and reagent disc (14) and make corresponding sample hose (11) rotate and be exposed to the front of camera (71), the label information on also collected specimens pipe (11) taken by camera (71).
8. chemiluminescence immune assay device according to claim 7, it is characterized in that, sample disc (12) is in the periphery of reagent disc (14), and camera (71) is in the outside of sample disc (12) and the sample hose (11) towards sample disc (12) is arranged.
9. chemiluminescence immune assay device according to claim 5, is characterized in that,
The rotating disk (21) that chemical reaction hatches mechanism (2) is provided with multiple through hole (211), quantity is corresponding with the quantity of reaction tray (22), and each through hole (211) is concentric with a corresponding reaction tray (22);
Chemical reaction is hatched mechanism (2) and is also comprised:
Multiple connecting link (25), quantity is corresponding with the quantity of reaction tray (22), and each connecting link (25) is through a corresponding through hole (211) and one end is removably fixedly connected on the bottom of a corresponding reaction tray (22); And
Multiple cup dolly (26), quantity is corresponding with the quantity of reaction tray (22), and each cup dolly (26) is fixedly connected on the other end of a corresponding connecting link (25);
The driving mechanism (24) that chemical reaction hatches mechanism (2) comprising:
Motor (241);
Main drive gear (242), power is connected to motor (241);
Multiple pinion wheel (243), quantity is corresponding with the quantity of reaction tray (22);
Multiple belt pulley (244), quantity is corresponding with the quantity of pinion wheel (243), and each belt pulley (244) is coaxially connected to a corresponding pinion wheel (243);
Many belts (245), quantity is corresponding with the quantity of belt pulley (244), and each belt (245) is corresponding on a corresponding belt pulley (244) and a corresponding cup dolly (26); And
Electromagnetic clutch (246), be fixedly connected with the bottom of rotating disk (21) and for engaging with main drive gear (242) or departing from, engage to make described multiple pinion wheel (243) and main drive gear (242) depart from or engage with main drive gear (242);
Wherein:
When electromagnetic clutch (246) engages with main drive gear (242), main drive gear (242) departs from described multiple pinion wheel (243) and engages, motor (241) drives rotating disk (21) to rotate, to realize the revolution of all reaction tray (22) on rotating disk (21) via the bottom of main drive gear (242), electromagnetic clutch (246) and rotating disk (21);
When electromagnetic clutch (246) departs from main drive gear (242), main drive gear (242) engages with described multiple pinion wheel (243), and motor (241) drives the rotation simultaneously of described multiple reaction tray (22) via the cup dolly (26) of main drive gear (242), described multiple pinion wheel (243), described multiple belt pulley (244) and described many belts (245), described multiple reaction tray (22) and described multiple connecting link (25).
10. chemiluminescence immune assay device according to claim 1, is characterized in that, cleaning needle (41) comprising:
Wash pin (411), in reaction cup (23), add cleaning fluid; And
Cleaning suction spindle (412), by liquid sucking-off unnecessary in reaction cup (23).
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