CN107884591A - Automatic cleaning separator - Google Patents
Automatic cleaning separator Download PDFInfo
- Publication number
- CN107884591A CN107884591A CN201711437813.7A CN201711437813A CN107884591A CN 107884591 A CN107884591 A CN 107884591A CN 201711437813 A CN201711437813 A CN 201711437813A CN 107884591 A CN107884591 A CN 107884591A
- Authority
- CN
- China
- Prior art keywords
- fluid injection
- imbibition
- automatic cleaning
- driver
- rotating disk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 64
- 238000002347 injection Methods 0.000 claims abstract description 159
- 239000007924 injection Substances 0.000 claims abstract description 159
- 239000012530 fluid Substances 0.000 claims abstract description 157
- 230000007246 mechanism Effects 0.000 claims abstract description 154
- 238000005213 imbibition Methods 0.000 claims abstract description 81
- 238000002156 mixing Methods 0.000 claims abstract description 75
- 239000007788 liquid Substances 0.000 claims abstract description 48
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 239000000376 reactant Substances 0.000 claims abstract description 6
- 238000011534 incubation Methods 0.000 claims description 19
- 230000001360 synchronised effect Effects 0.000 claims description 15
- 230000000694 effects Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000005291 magnetic effect Effects 0.000 description 15
- 238000000926 separation method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000008450 motivation Effects 0.000 description 2
- 230000005298 paramagnetic effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
Abstract
The present invention relates to a kind of automatic cleaning separator, and for removing the composition being not associated with reaction vessel in reactant, the automatic separator that cleans includes：Fluid injection mixing mechanism, removing component, liquid sucting mechanism.Fluid injection driver is installed on fluid injection mixing mechanism, imbibition driver is installed on liquid sucting mechanism, fluid injection driver driving fluid injection mixing mechanism, which moves up and down, completes fluid injection, imbibition driver driving liquid sucting mechanism, which moves up and down, completes imbibition, and removing component removes the reaction vessel on fluid injection mixing mechanism under the relative motion of liquid sucting mechanism and fluid injection mixing mechanism.The automatic cleaning separator overall structure is simple, is easy to manufacture, and the movement travel of mechanism and time are short, cleaning good separating effect, efficiency high, very useful.
Description
Technical field
The present invention relates to the technical field of in-vitro diagnosis automation immunoassay equipment, more particularly to a kind of automatic cleaning
Separator.
Background technology
Automatic chemiluminescence immunoassay is an important technology of in-vitro diagnosis automated analysis, and the technology is mainly led to
Full-automatic chemiluminescence is crossed instrument is immunized to complete.Be immunized in Full-automatic chemiluminescence in instrument, in order to realize free label and
The separation of immune complex label, it usually needs cleaning separation circuit is carried out through over cleaning separator, to remove reactant
In the composition that is not associated with, then complete luminescence-producing reaction on the basis of immune compound token thing.
It is existing to clean separator to reach cleaning separation function, it usually needs to be provided with the cleaning point independently driven
Separation disc, liquid sucting mechanism, mechanism for filling liquid, mix grasping mechanism and removing mechanism etc. component, so as to cause to clean separator and
Overall complicated of analyzer, volume is big, and it is big to manufacture difficulty, in addition, it is low etc. cleaning inferior separating effect, efficiency to be also present
Problem, so as to the accuracy of impact analysis detection.
The content of the invention
Based on this, it is necessary to the problem of existing for cleaning separator, there is provided one kind is simple in construction, is easy to production to make
Make, clean good separating effect, the automatic cleaning separator of efficiency high.
A kind of automatic cleaning separator, for removing the composition being not associated with reaction vessel in reactant, its feature exists
In the automatic cleaning separator includes：Fluid injection mixing mechanism, removing component, liquid sucting mechanism；On the fluid injection mixing mechanism
Fluid injection driver is installed, imbibition driver is installed on the liquid sucting mechanism, the fluid injection driver drives the fluid injection to mix
Even mechanism, which moves up and down, completes fluid injection, and the imbibition driver drives the liquid sucting mechanism to move up and down and completes imbibition, described de-
Except component removed under the relative motion of the liquid sucting mechanism and the fluid injection mixing mechanism it is anti-on the fluid injection mixing mechanism
Answer container.
In one of the embodiments, in addition to rotary drive mechanism, rotating disk mechanism, the rotating disk mechanism are installed on described
On rotating mechanism, the fluid injection mixing mechanism is installed on the rotating disk mechanism.
In one of the embodiments, the rotary drive mechanism includes bottom plate, the electric rotating being installed on the bottom plate
Machine, the rotation synchronization belt being installed on the electric rotating machine, the rotation synchronization belt are connected with the rotating disk mechanism.
In one of the embodiments, the rotating disk mechanism includes fireless cooker, is installed on the rotary drive mechanism
Rotating disk, the rotating disk is provided with some incubation slots and cleaning separating tank, the incubation slot are arranged on the rotating disk in inner ring, institute
Cleaning separating tank is stated to arrange in outer ring on the rotating disk.
In one of the embodiments, disk cover is installed, the disk cover is located at the incubation slot, cleaning on the fireless cooker
It is connected above separating tank and with the fluid injection mixing mechanism.
In one of the embodiments, the disk cover is provided with some first access holes, the second access hole, the 3rd access hole
And the 4th access hole, first access hole are oppositely arranged with wherein some incubation slots, second access hole and the cleaning
Separating tank is oppositely arranged, and the 3rd access hole is used for imbibition, and the 4th access hole is used for fluid injection.
In one of the embodiments, the imbibition driver of the liquid sucting mechanism is connected with the fluid injection mixing mechanism
Connect.In one of the embodiments, it is characterised in that the fluid injection mixing mechanism includes supporting cell guide, is installed on the support
Fluid injection plate on guide pillar, the mixing driver being installed on the fluid injection plate and at least two mix components and fluid injection needle tubing,
The mixing driver is connected with the mixing component, and the fluid injection needle tubing passes through the fluid injection plate from above the fluid injection plate.
In one of the embodiments, the mixing component includes synchronous pulley and mixes chuck；The removing component bag
Removing bar and spring are included, the fluid injection needle tubing passes through among the mixing component and removing component.
In one of the embodiments, the liquid sucting mechanism includes imbibition plate, the installation being installed on the supporting cell guide
In at least two imbibition needle tubings on the imbibition plate, the imbibition plate is located at the top of the fluid injection plate.
Above-mentioned automatic cleaning separator, including rotary drive mechanism, be installed on rotary drive mechanism rotating disk mechanism,
The fluid injection mixing mechanism being installed on rotating disk mechanism, the removing group valency and liquid sucting mechanism that are installed on fluid injection mixing mechanism, use
When, separator will be entirely cleaned automatically on Full-automatic chemiluminescence immunoassay analysis meter.The automatic cleaning separator
Component and liquid sucting mechanism realization incubation are removed by rotary drive mechanism, rotating disk mechanism, fluid injection mixing mechanism, shifts and transports,
Magnetic suck, fluid injection, imbibition, mixing, de- pipe operation are integrated in one, simple and compact for structure, are easy to manufacture.Driven by fluid injection
Device, mix driver and imbibition driver these three power sources can realize multiple reaction vessels while carry out dividing for not same order
From, fluid injection, mixing and imbibition operation, mode of operation is simple and reliable, separation cleaning good separating effect, efficiency high, ensure that follow-up
Analyze the accuracy of detection.
Brief description of the drawings
Fig. 1 is the schematic diagram that a preferred embodiment of the present invention cleans separator automatically；
Fig. 2 is the schematic diagram of another visual angle of automatic cleaning separator shown in Fig. 1；
Fig. 3 is the partial schematic diagram of automatic cleaning separator transfer disc mechanism shown in Fig. 1；
Fig. 4 is that fluid injection mixing mechanism, removing component, liquid sucting mechanism are incorporated in one in automatic cleaning separator shown in Fig. 1
The partial schematic diagram risen；
Accompanying drawing marks explanation：
100- cleans separator automatically, and 20- rotary drive mechanisms, 21- bottom plates, 22- electric rotating machines, 23- rotations are synchronously
Band, 30- rotating disk mechanisms, 31- magnetic parts, 32- fireless cookers, 33- rotating disks, 34- incubation slots, 35- cleaning separating tanks, 36- disk covers,
The initial fluid injection components of 38-, the access holes of 361- first, the access holes of 362- second, the access holes of 363- the 3rd, the access holes of 364- the 4th,
40- fluid injection mixing mechanisms, 41- fluid injection drivers, 42- supporting cell guides, 43- fluid injection plates, 44- mix driver, 45- mixing groups
Part, 46- fluid injection needle tubings, 47- are oriented to idle pulley, and 48- mixes timing belt, 411- fluid injection drive rods, the guide sleeves of 431- first, 432- branch
Brace, 451- synchronous pulleys, 452- mix chuck, 50- removing components, 51- removing bars, 52- springs, 60- liquid sucting mechanisms, 61-
Imbibition plate, 62- imbibition drivers, 63- imbibition needle tubings, the guide sleeves of 64- second, 70- reaction vessels.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In accompanying drawing
Give presently preferred embodiments of the present invention.But the present invention can realize in many different forms, however it is not limited to this paper institutes
The embodiment of description.On the contrary, the purpose for providing these embodiments is to make the understanding to the disclosure more thorough
Comprehensively.
It should be noted that when element is referred to as " being fixed on " another element, it can be directly on another element
Or there may also be element placed in the middle.When an element is considered as " connection " another element, it can be directly connected to
To another element or it may be simultaneously present centering elements.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The automatic cleaning separator 100 of the present invention, for carrying out cleaning separation to the reactant in reaction vessel 70, goes
Except the composition being not associated with reactant in reaction vessel 70.Automatic cleaning separator 100 includes：Fluid injection mixing mechanism 40, take off
Except component 50, liquid sucting mechanism 60.Fluid injection driver 41 is installed on fluid injection mixing mechanism 40, imbibition is installed on liquid sucting mechanism 60
Driver 62, fluid injection driver 41 drive fluid injection mixing mechanism 40 to move up and down and complete fluid injection, and imbibition driver 62 drives imbibition
Mechanism 60, which moves up and down, completes imbibition, and removing component 50 removes under the relative motion of liquid sucting mechanism 60 and fluid injection mixing mechanism 40
Reaction vessel 70 on fluid injection mixing mechanism 40.
Fig. 1 to Fig. 4 is refer to, is the automatic cleaning separator 10 of a preferred embodiment of the present invention, in addition to rotate and drive
Motivation structure 20, rotating disk mechanism 30, rotating disk mechanism 30 are installed on rotating mechanism 20, and fluid injection mixing mechanism 40 is installed on rotating disk mechanism
On 30.The imbibition driver 62 of liquid sucting mechanism 60 is connected with fluid injection mixing mechanism 40, it is necessary to illustrate, in other embodiment
In, imbibition driver 62 can be connected with the miscellaneous part of rotary drive mechanism 20 or Full-automatic chemiluminescence immunoassay analysis meter.
In use, separator 100 will be entirely cleaned automatically on Full-automatic chemiluminescence immunoassay analysis meter.Need what is illustrated
It is that in other embodiments, fluid injection mixing mechanism 40 can be arranged on rotary drive mechanism 20 or Full-automatic chemiluminescence is immunized
On the miscellaneous part of analyzer.Rotating disk mechanism 30 is used to placing and transporting reaction vessel 70, and rotary drive mechanism 20 drives rotating disk
Mechanism 30 rotates so that reaction vessel 70 mixes by fluid injection mixing mechanism 40 and liquid sucting mechanism 60, liquid sucting mechanism 60, fluid injection
Mechanism 50 completes multiple imbibition, fluid injection in reaction vessel 70, mixes work, finally realizes the cleaning work of separation in immunoassay
Energy.
Referring to Figures 1 and 2, the rotary drive mechanism 20 include bottom plate 21, be installed on bottom plate 21 electric rotating machine 22,
The electric rotating machine 22 being installed on bottom plate 21, the rotation synchronization belt 23 being installed on electric rotating machine 22, rotation synchronization belt 23 is with turning
Disc mechanism 30 connects.Electric rotating machine 22 is located at the edge of bottom plate 21, can so ensure electric rotating machine 22 and rotating disk mechanism 30
Locus arrangement, reduce space hold.
Fig. 3 is referred again to, the rotating disk mechanism 30 is provided with magnetic part 31, magnetic on the side of fluid injection mixing mechanism 40
Part 31 provides magnetic field environment, the paramagnetic particle in reaction vessel 70 is adsorbed onto the inwall regular hour of reaction vessel 70,
Usually several seconds to tens seconds, before so ensureing each imbibition, reaction vessel 70 was needed by magnetic field for a period of time.At it
In his embodiment, magnetic part 31 can not be arranged on according to being actually needed on rotating disk mechanism 30, an outside branch can be passed through
Support mechanism installs magnetic part 31 to provide magnetic field environment.Rotating disk mechanism 30 includes fireless cooker 32, the installation being arranged on bottom plate 21
Some incubation slots 34 are provided with the rotating disk 33 on rotary drive mechanism 20, rotating disk 33 and cleaning separating tank 35, magnetic part 31 are pacified
Mounted in fireless cooker 32 on the side of electric rotating machine 22, rotating disk 33 is connected with rotation synchronization belt 23, and incubation slot 34 is in rotating disk 33
It is upper to be arranged in inner ring, it is specially three circle arrangements in this implementation, cleaning separating tank 35 is arranged on rotating disk 33 in outer ring.In use,
Incubation slot 34 and cleaning separating tank 35 are used for placing response container 70, and reaction vessel 70 is under the driving of electric rotating machine 22 with rotating disk
33 rotate, and rhizosphere is actually needed rotates advance a position or multiple positions every time.Further, disk is installed on fireless cooker 32
Lid 36, disk cover 36 are located at incubation slot 34, the top of cleaning separating tank 35 and are connected with fluid injection mixing mechanism 40, and disk cover 36 is provided with one
Individual initial fluid injection component 38.The keeping warmth space of a relative closure, initial fluid injection component 38 are formed between fireless cooker 32, disk cover 36
First fluid injection is carried out before reaction vessel 70 enters fluid injection mixing mechanism 40, liquid sucting mechanism 50.
Further, the disk cover 36 is provided with some access holes 362 of first access hole 361 and second, and first comes in and goes out
Hole 361 is oppositely arranged with wherein some incubation slots 34, and the second access hole 362 is oppositely arranged with cleaning separating tank 35, the present embodiment
In, there are three the first access holes 361, incubation time of the reaction vessel 70 on incubation slot 34 can be by turning with rotating disk 33
Dynamic reaction vessel 70 is placed and taken out determining from which the first access hole 361.Second access hole 362 separates with wherein some cleanings
Groove 34 is oppositely arranged, and in the present embodiment, there is three the second access holes 362, the second access hole 362 is used for reaction vessel disengaging cleaning
Separating tank 34.Some 3rd access holes 363 and the 4th access hole 364 are additionally provided with disk cover 36, the 3rd access hole 363 is used for imbibition
Processing, the 4th access hole 364 are used for fluid injection processing, it is generally the case that the 3rd access hole 363 and the 4th access hole 364 phase one by one
Pair set, the 3rd access hole 363 is easy to through carrying out imbibition, and the 4th access hole 364 is easy to through carrying out fluid injection.People in the art
Member is appreciated that relative set is not essential one by one for the 3rd access hole 363 and the 4th access hole 364, in some embodiments, the
Three access holes 363 and the 4th access hole 364, which can merge, to be set up, and is easy to pass through progress imbibition and fluid injection in same position.
Fig. 4 is referred again to, fluid injection driver 41 is installed on the mechanism for filling liquid 40, fluid injection driver 41 supports with disk cover 36
Connect, fluid injection driver 41 drives fluid injection mixing mechanism 40 to move up and down and completes fluid injection.It will be appreciated by those skilled in the art that, note
Liquid mixing mechanism 40 is abutted with disk cover 36 and is not essential, and in other embodiments, fluid injection mixing mechanism 40 can also be installed on
The bottom plate of rotary drive mechanism 20 is first-class.In this implementation, fluid injection mixing mechanism 40 include be connected with disk cover 36 supporting cell guide 42,
The fluid injection plate 43 being installed on supporting cell guide 42, the mixing driver 44 and at least two being installed on fluid injection plate 43 mix
Component 45 and fluid injection needle tubing 46, fluid injection needle tubing 46 is passed through among mixing component 45 and removing component 50 and the 4th access hole 364
Adaptation.Further, fluid injection needle tubing 46 is three groups in the present embodiment, fluid injection driver 41, fluid injection plate 43 drive under can be with
The fluid injection of three groups of different cleaning opening positions of separating tank 35 is carried out simultaneously.Mix driver 44 and be connected with mixing component 45, injection needle
Pipe 46 is oppositely arranged from above fluid injection plate 43 through fluid injection plate 43 with disk cover 36.Support arm 432 is installed on fluid injection plate 43 and led
To idle pulley 47, support arm 432, which is located at the outer rim of fluid injection plate 43, to be used to support fluid injection needle tubing 46.The component 45 that is mixed includes timing belt
Wheel 451 and mixing chuck 452, synchronous pulley 451 are arranged on fluid injection plate 43, are mixed chuck 452 and are connected with synchronous pulley 451,
Mix the screen resilience clamping reaction vessel 70 of 452 reliable chuck of chuck.
Mix to be provided with driver 44 and mix timing belt 48, mix timing belt 48 with being oriented to idle pulley 47, synchronous pulley 451
Abutting is passed around, mixing driver 44 can drive the reaction vessel 70 for being clamped in mixing chuck 455 to enter by mixing timing belt 48
Row rotation, so as to realize the mixing of reaction vessel 70.The first guide sleeve being connected with fluid injection plate 43 is set with supporting cell guide 42
431, the fluid injection drive rod 411 abutted with disk cover 36 is installed on fluid injection driver 41, the first guide sleeve 431 ensure that fluid injection plate
43 in the presence of fluid injection driver 41, fluid injection drive rod 411 up and down smooth sliding.Wherein fluid injection driver 41 can be driving
Motor or drive cylinder, the present embodiment select motor, and mixing driver 44 is motor.
Further, the removing component 50 includes removing bar 51 and spring 52, wherein the motor synchronizing belt wheel of fluid injection needle tubing 46
Passed through among removing bar 51, spring 52, synchronous pulley 451 and mixing chuck 452.Wherein specifically, the top for removing bar 51 leads to
Cross spring 52 and be overlapped on the top of synchronous pulley 451, lower section passes through from synchronous pulley 452.In other embodiments, component 50 is removed
It can also be connected directly between on liquid sucting mechanism 60, follow the lifting of liquid sucting mechanism 60 1, removing component 50 can not also include bullet
Spring 52, removing component 50 can also be any other suitable part, and its one end, which can pass through to mix component 45 and push to react, to be held
The upper port of device 70 makes reaction vessel 70 be removed from component 45 is mixed.Fluid injection needle tubing 46 is used for the reaction vessel 70 after completion imbibition
Interior injection cleaning buffer solution or signal reagent, mix the screen resilience clamping reaction vessel 70 of 452 reliable chuck of chuck.Remove bar 51
Through synchronous pulley 451, spring 52 is located at synchronous pulley 451 close to one end of liquid sucting mechanism 60, mixes chuck 452 positioned at synchronous
Belt wheel 451 can move up and down close to one end of rotating disk mechanism 30, removing bar 51 in the through hole of synchronous pulley 451.In this implementation
In, removing bar 51 be oppositely arranged with liquid sucting mechanism 50 but and be not connected with, in other implementations removing bar 51 connect with liquid sucting mechanism 60
Connect also to can be achieved on and moved up and down in the through hole of synchronous pulley 452.
The imbibition driver 62 being connected with fluid injection mixing mechanism 40 is installed in reference picture 4, the liquid sucting mechanism 60, inhaled
Hydraulic driver 62 drives liquid sucting mechanism 40 to move up and down and completes imbibition, and liquid sucting mechanism 40 can move with fluid injection mixing mechanism 40
Or done relative motion with fluid injection mixing mechanism 40.It will be appreciated by those skilled in the art that, liquid sucting mechanism 60 and fluid injection mixing machine
The connection of structure 40 is not essential, and in other embodiments, liquid sucting mechanism 60 can also be connected on disk cover 36, be installed on rotation drive
The bottom plate 21 of motivation structure 20 is first-class.Further, liquid sucting mechanism 60 includes imbibition plate 61, the installation being installed on supporting cell guide 42
In at least two imbibition needle tubings 63 on imbibition plate 61, imbibition plate 61 is located at the top of fluid injection plate 43, imbibition driver 62 and note
Liquid plate 43 connects, and imbibition needle tubing 36 is passed down through fluid injection plate 43 from imbibition plate 61, imbibition needle tubing 63 and fluid injection needle tubing 46 phase one by one
To setting and positioned at the top of the 3rd access hole 363.Wherein, it is provided with imbibition plate 61 and is socketed be adapted to the with supporting cell guide 42
Two guide sleeves 64, it is stable can to ensure that imbibition plate 61 moves up and down smooth-going by the second guide sleeve 64.In the present embodiment, aspirating needle
Pipe 63 is three groups, above disk cover 36 and with the 3rd access hole 363 is adapted to use, in imbibition driver 62, imbibition plate 61
Drive the lower imbibition that can carry out three groups of different cleaning separating tank opening positions simultaneously.Wherein imbibition driver 52 can be driving electricity
Machine or drive cylinder, the present embodiment select motor.
The automatic cleaning separator 100 mainly includes procedure below：
Imbibition process：Fluid injection driver 41 drives fluid injection plate 43 to drop to after bottom position and stands motionless, now aspirating needle
Pipe 63 drops in reaction vessel 70, but does not drop to the bottom of reaction vessel 70, and then imbibition driver 62 drives imbibition plate
61 continue to decline, and until driving imbibition needle tubing 63 to drop to the bottom position of reaction vessel 70, imbibition needle tubing 63 is in reaction vessel 70
Complete imbibition in bottom.
Fluid injection blending process：Fluid injection driver 41 drives fluid injection plate 43 to drop to bottom and grabs pipe height, mixes the profit of chuck 452
With the top of chuck elastic clamping reaction vessel 70, then the drive fluid injection of fluid injection driver 41 plate 43 rises to fluid injection and mixing is high
Degree.The fluid injection into reaction vessel 70 of fluid injection needle tubing 46, while mix driver 44 and be driven by mixing timing belt 48, drive synchronous
Belt wheel 451 and mix chuck 452 and rotate, so as to drive reaction vessel 70 to rotate, make paramagnetic particle resuspension and dispersed
In cleaning buffer solution.
Subtractive process：While fluid injection driver 41 drives the rising of fluid injection plate 43, imbibition driver 62 drives imbibition plate 61
Decline relative to fluid injection plate 43 and move, when imbibition plate 61 pushes removing bar 51, the other end of removing bar 51 pushes away reaction vessel 70
Pressure, which exits, mixes chuck 452.Then fluid injection driver 41 continues to drive fluid injection plate 43 to rise to initial bit, the band of imbibition driver 62
Dynamic imbibition plate 61 returns to initial bit, and removing bar 51 returns to initial bit under the restoring force of spring 52.
The present embodiment by the mass motion and relative motion of imbibition plate 61 and fluid injection plate 43, can not only complete fluid injection and
Imbibition, removing component is also set to complete to mix the reaction vessel on chuck 452 under the relative motion of imbibition plate 61 and fluid injection plate 43
70 removing.The run time of liquid sucting mechanism 60 is not only saved, complete machine speed is improved, also eliminates dedicated for removing
Independent driving mechanism, complete machine structure is simplified, occupied little space, saved cost, make whole automatic cleaning separator 100 more
It is compact, improve reliability.
The automatic cleaning separator 100 on the incubation slot 34 of rotating disk 33 by manipulator in use, will be incubated one section
The reaction vessel 70 that time or incubation are completed is transferred to cleaning separating tank 35 by the first access hole 361, the second access hole 362
On.Electric rotating machine 22 drives rotating disk 33 to rotate, and the reaction vessel 70 cleaned on separating tank 35 is transported into fluid injection mixing mechanism 40
Below liquid sucting mechanism 60, while field region caused by magnetic part 31 on fireless cooker 32 is entered, the magnetic in reaction vessel 70
The reaction vessel inwall that particulate just moves closer to the side of magnetic part 31 in the environment of magnetic field gathers.When reaction vessel 70 reaches the
During single order imbibition 63 lower section of needle tubing, start the first rank imbibition process, after the completion of the first rank imbibition, rotating disk 33 is in electric rotating machine 22
Lower one position of rotation advance is driven, the reaction vessel 70 for completing the first rank imbibition is transported to up under the first rank fluid injection needle tubing 46
Side, start the first rank injection process of the reaction vessel 70.Similar, reaction vessel 70 reaches second-order imbibition needle tubing successively
63rd, second-order fluid injection needle tubing 46, the 3rd rank imbibition needle tubing 63, the lower section of the 3rd rank fluid injection needle tubing 46, complete imbibition and injection process,
Wherein last rank fluid injection needle tubing 46 carries out signal reagent fluid injection, and the reaction vessel 70 subsequently entered also once undergoes the first rank, the
Second order and the process of the 3rd rank.This technology personnel according to actual test it should be understood that in other embodiments, can need to set
When counting the test needle tubing of not same order, for example carrying out quadravalence test, four groups of imbibition needle tubings 63 and fluid injection needle tubing can be correspondingly arranged
46。
Above-mentioned automatic cleaning separator 100, including rotary drive mechanism 20, be installed on rotary drive mechanism 20 and turn
Disc mechanism 30, the fluid injection mixing mechanism 40 being installed on rotating disk mechanism 30, the removing component being installed on fluid injection mixing mechanism 40
50 and liquid sucting mechanism 60, in use, will entirely clean separator 100 automatically is arranged on Full-automatic chemiluminescence immunoassay analysis meter
On.The automatic cleaning separator 100 passes through rotary drive mechanism 20, rotating disk mechanism 30, fluid injection mixing mechanism 40, removing component
50 and liquid sucting mechanism 60 realize be incubated, transfer and transhipment, magnetic suck, fluid injection, imbibition, mixing, de- pipe are operated and are integrated in one, structure
Simple and compact, it is easy to manufacture.By fluid injection driver 41, mix driver 44 and imbibition driver 62 these three power sources
Multiple reaction vessels 70 can be realized while carry out separation, fluid injection, mixing and the imbibition operation of not same order, mode of operation simply may be used
Lean on, separation cleaning good separating effect, efficiency high, ensure that the accuracy of subsequent analysis detection.
This technology personnel are appreciated that apparatus of the present invention to complete fluid injection and imbibition, also relate to syringe (pump), inhale
The fluid devices such as liquid peristaltic pump (or vavuum pump), fluid circuit and the circuit of correlation, software controlled unit, these are ability
Domain general technology, the present invention are not discussed in detail.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope that this specification is recorded all is considered to be.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more specific and detailed, but simultaneously
Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that come for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
- A kind of 1. automatic cleaning separator, for removing the composition being not associated with reaction vessel in reactant, it is characterised in that The automatic cleaning separator includes：Fluid injection mixing mechanism, removing component, liquid sucting mechanism；Pacify on the fluid injection mixing mechanism Equipped with fluid injection driver, imbibition driver is installed on the liquid sucting mechanism, the fluid injection driver drives the fluid injection to mix Mechanism, which moves up and down, completes fluid injection, and the imbibition driver drives the liquid sucting mechanism to move up and down and completes imbibition, the removing Component removes the reaction on the fluid injection mixing mechanism under the relative motion of the liquid sucting mechanism and the fluid injection mixing mechanism Container.
- 2. automatic cleaning separator according to claim 1, it is characterised in that also including rotary drive mechanism, rotating disk Mechanism, the rotating disk mechanism are installed on the rotating mechanism, and the fluid injection mixing mechanism is installed on the rotating disk mechanism.
- 3. automatic cleaning separator according to claim 2, it is characterised in that the rotary drive mechanism includes bottom Plate, the electric rotating machine being installed on the bottom plate, the rotation synchronization belt being installed on the electric rotating machine, the rotation synchronization belt It is connected with the rotating disk mechanism.
- 4. automatic cleaning separator according to claim 2, it is characterised in that the rotating disk mechanism include fireless cooker, The rotating disk being installed on the rotary drive mechanism, the rotating disk are provided with some incubation slots and cleaning separating tank, the incubation Groove is arranged on the rotating disk in inner ring, and the cleaning separating tank is arranged on the rotating disk in outer ring.
- 5. automatic cleaning separator according to claim 4, it is characterised in that disk cover is installed on the fireless cooker, The disk cover is located at the incubation slot, cleaning separating tank top and is connected with the fluid injection mixing mechanism.
- 6. automatic cleaning separator according to claim 5, it is characterised in that the disk cover goes out provided with some first Enter hole, the second access hole, the 3rd access hole and the 4th access hole, first access hole is relative with wherein some incubation slots to be set Put, second access hole is oppositely arranged with the cleaning separating tank, and the 3rd access hole is used for imbibition, and the described 4th comes in and goes out Hole is used for fluid injection.
- 7. automatic cleaning separator according to claim 1, it is characterised in that the imbibition of the liquid sucting mechanism is driven Dynamic device is connected with the fluid injection mixing mechanism.
- 8. according to the automatic cleaning separator described in any one of claim 1 to 7, it is characterised in that the fluid injection mixes Mechanism include supporting cell guide, be installed on the supporting cell guide fluid injection plate, be installed on the fluid injection plate mixing driver, And at least two mix component and fluid injection needle tubing, the mixing driver is connected with the component that mixes, the fluid injection needle tubing The fluid injection plate is passed through from above the fluid injection plate.
- 9. automatic cleaning separator according to claim 8, it is characterised in that the mixing component includes synchronous pulley And mix chuck；The removing component includes removing bar and spring, and the fluid injection needle tubing mixes component and removing component from described Centre passes through.
- 10. automatic cleaning separator according to claim 9, it is characterised in that the liquid sucting mechanism includes being installed on Imbibition plate on the supporting cell guide, at least two imbibition needle tubings being installed on the imbibition plate, the imbibition plate are located at institute State the top of fluid injection plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711437813.7A CN107884591A (en) | 2017-12-26 | 2017-12-26 | Automatic cleaning separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711437813.7A CN107884591A (en) | 2017-12-26 | 2017-12-26 | Automatic cleaning separator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107884591A true CN107884591A (en) | 2018-04-06 |
Family
ID=61771434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711437813.7A Pending CN107884591A (en) | 2017-12-26 | 2017-12-26 | Automatic cleaning separator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107884591A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019127016A1 (en) * | 2017-12-26 | 2019-07-04 | 深圳迎凯生物科技有限公司 | Automatic cleaning and separating device |
| WO2020041923A1 (en) * | 2018-08-27 | 2020-03-05 | 深圳迎凯生物科技有限公司 | Cleaning method and sample analysis method |
| CN111077834A (en) * | 2019-12-30 | 2020-04-28 | 珠海丽珠试剂股份有限公司 | Container cleaning control system and method and electronic equipment |
| CN112098666A (en) * | 2020-11-09 | 2020-12-18 | 宁波海壹生物科技有限公司 | Cleaning system for full-automatic chemiluminescence immunoassay analyzer |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04142462A (en) * | 1990-10-02 | 1992-05-15 | Otsuka Denshi Kk | Distributing device for inspecting reaction container |
| JPH10142231A (en) * | 1996-09-19 | 1998-05-29 | Abbott Lab | Method of determining concerned item in sample |
| US20010012492A1 (en) * | 1997-11-14 | 2001-08-09 | Gen-Probe Incorporated | Assay work station |
| JP2002286726A (en) * | 1995-05-29 | 2002-10-03 | Hitachi Ltd | Analyzer using disposable reaction container |
| WO2003036304A1 (en) * | 2001-10-26 | 2003-05-01 | Advion Biosciences, Inc. | Method and device for chemical analysis |
| US6893611B1 (en) * | 1998-03-20 | 2005-05-17 | Fondation Jean Dausset-Ceph | Automatic device for dispensing samples in liquid medium for use in chemical or biological reactions |
| US20070062316A1 (en) * | 2005-09-05 | 2007-03-22 | Sysmex Corporation | Liquid sample suctioning device and analyzer |
| KR20090107927A (en) * | 2008-04-09 | 2009-10-14 | (주)바이오니아 | The automatic purification apparatus, multi well plate kit and isolation method of nucleic acid from biological samples |
| CN205301341U (en) * | 2015-12-23 | 2016-06-08 | 深圳雷杜生命科学股份有限公司 | Anticollision formula self - cleaning , mixing and separator |
| CN106645765A (en) * | 2017-01-06 | 2017-05-10 | 刘丹 | Automatic analysis device and sample analysis method |
| CN106841644A (en) * | 2017-01-06 | 2017-06-13 | 刘丹 | Automatic analysing apparatus and method of sample analysis |
| CN207623358U (en) * | 2017-12-26 | 2018-07-17 | 深圳迎凯生物科技有限公司 | Automatic cleaning separator |
-
2017
- 2017-12-26 CN CN201711437813.7A patent/CN107884591A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04142462A (en) * | 1990-10-02 | 1992-05-15 | Otsuka Denshi Kk | Distributing device for inspecting reaction container |
| JP2002286726A (en) * | 1995-05-29 | 2002-10-03 | Hitachi Ltd | Analyzer using disposable reaction container |
| JPH10142231A (en) * | 1996-09-19 | 1998-05-29 | Abbott Lab | Method of determining concerned item in sample |
| US20010012492A1 (en) * | 1997-11-14 | 2001-08-09 | Gen-Probe Incorporated | Assay work station |
| US6893611B1 (en) * | 1998-03-20 | 2005-05-17 | Fondation Jean Dausset-Ceph | Automatic device for dispensing samples in liquid medium for use in chemical or biological reactions |
| WO2003036304A1 (en) * | 2001-10-26 | 2003-05-01 | Advion Biosciences, Inc. | Method and device for chemical analysis |
| US20070062316A1 (en) * | 2005-09-05 | 2007-03-22 | Sysmex Corporation | Liquid sample suctioning device and analyzer |
| JP2007071575A (en) * | 2005-09-05 | 2007-03-22 | Sysmex Corp | Liquid sample sucking device and analyzer equipped with it |
| KR20090107927A (en) * | 2008-04-09 | 2009-10-14 | (주)바이오니아 | The automatic purification apparatus, multi well plate kit and isolation method of nucleic acid from biological samples |
| CN205301341U (en) * | 2015-12-23 | 2016-06-08 | 深圳雷杜生命科学股份有限公司 | Anticollision formula self - cleaning , mixing and separator |
| CN106645765A (en) * | 2017-01-06 | 2017-05-10 | 刘丹 | Automatic analysis device and sample analysis method |
| CN106841644A (en) * | 2017-01-06 | 2017-06-13 | 刘丹 | Automatic analysing apparatus and method of sample analysis |
| CN207623358U (en) * | 2017-12-26 | 2018-07-17 | 深圳迎凯生物科技有限公司 | Automatic cleaning separator |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019127016A1 (en) * | 2017-12-26 | 2019-07-04 | 深圳迎凯生物科技有限公司 | Automatic cleaning and separating device |
| US11835534B2 (en) | 2017-12-26 | 2023-12-05 | Shenzhen Increcare Biotech Co. Ltd | Automatic cleaning and separating device |
| WO2020041923A1 (en) * | 2018-08-27 | 2020-03-05 | 深圳迎凯生物科技有限公司 | Cleaning method and sample analysis method |
| CN111077834A (en) * | 2019-12-30 | 2020-04-28 | 珠海丽珠试剂股份有限公司 | Container cleaning control system and method and electronic equipment |
| CN111077834B (en) * | 2019-12-30 | 2023-05-12 | 珠海丽珠试剂股份有限公司 | Container cleaning control system and method and electronic equipment |
| CN112098666A (en) * | 2020-11-09 | 2020-12-18 | 宁波海壹生物科技有限公司 | Cleaning system for full-automatic chemiluminescence immunoassay analyzer |
| CN112098666B (en) * | 2020-11-09 | 2021-02-09 | 宁波海壹生物科技有限公司 | Cleaning system for full-automatic chemiluminescence immunoassay analyzer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN207181272U (en) | Magnetic bead cleans separator and immunity analysis instrument automatically | |
| CN107884591A (en) | Automatic cleaning separator | |
| CN106706942B (en) | Automatic analysing apparatus and method of sample analysis | |
| CN106841644B (en) | Automatic analysing apparatus and method of sample analysis | |
| CN205656203U (en) | A sampling device for immune quantitative analysis appearance | |
| WO2021138963A1 (en) | Fully automatic chemiluminescent immune analyzer | |
| CN207866714U (en) | Chemiluminescence detector | |
| CN205374482U (en) | Full -automatic fluorescent quantitation immunoassay appearance | |
| CN105572407A (en) | Full-automatic fluorescent quantitative immunity analyzer and detection method | |
| CN107942085A (en) | Automatic analysing apparatus and its method of sample analysis | |
| CN109917145B (en) | Full-automatic chemiluminescence immunoassay instrument | |
| CN109142768A (en) | Automatic analysing apparatus and method of sample analysis | |
| US10613106B2 (en) | Reaction vessel handling apparatus, testing apparatus, and methods using same | |
| US20170088831A1 (en) | Nucleic acid extraction apparatus and method of operation | |
| WO2019033312A1 (en) | Blood analyzer and control method therefor | |
| JP2019120699A (en) | Chemiluminescence detector and its detection method | |
| WO2019127016A1 (en) | Automatic cleaning and separating device | |
| CN103439522B (en) | Specific protein analyzer | |
| CN105388314A (en) | Fully automated sample adding instrument | |
| CN103760373B (en) | Cleaning device in fully-automatic chemiluminescence immunity analyzer | |
| US11504753B2 (en) | Cleaning module, sample analyzer with cleaning module and cleaning method | |
| CN205301342U (en) | Automatic washing, mixing and separator | |
| CN104722526A (en) | Magnetism separating device | |
| CN110327659A (en) | A kind of extraction and purification method and device based on magnetic fiber material | |
| CN204544866U (en) | A kind of magnetic separating device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |