CN108732163A - Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
- Publication number
- CN108732163A CN108732163A CN201810820822.2A CN201810820822A CN108732163A CN 108732163 A CN108732163 A CN 108732163A CN 201810820822 A CN201810820822 A CN 201810820822A CN 108732163 A CN108732163 A CN 108732163A
- Authority
- CN
- China
- Prior art keywords
- cleaning
- pedestal
- driving
- evenly mixing
- hoistable platform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 31
- 238000003018 immunoassay Methods 0.000 title claims abstract description 31
- 238000004140 cleaning Methods 0.000 claims abstract description 96
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 86
- 238000002156 mixing Methods 0.000 claims abstract description 77
- 230000037452 priming Effects 0.000 claims abstract description 43
- 238000005086 pumping Methods 0.000 claims abstract description 40
- 238000001514 detection method Methods 0.000 claims abstract description 36
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 35
- 230000003287 optical effect Effects 0.000 claims abstract description 29
- 239000011148 porous material Substances 0.000 claims abstract description 20
- 238000007689 inspection Methods 0.000 claims abstract description 8
- 238000002347 injection Methods 0.000 claims description 25
- 239000007924 injection Substances 0.000 claims description 25
- 238000010438 heat treatment Methods 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 21
- 230000005540 biological transmission Effects 0.000 claims description 18
- 230000007246 mechanism Effects 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 8
- 238000003825 pressing Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 238000005096 rolling process Methods 0.000 claims description 3
- 230000008450 motivation Effects 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 description 20
- 230000005693 optoelectronics Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 10
- 230000007423 decrease Effects 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000003028 elevating effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of Full-automatic chemiluminescence immunoassay analysis meters, are related to the field of medical instrument technology.The analyzer includes pedestal, cleaning evenly mixing device and optical detection apparatus are provided on pedestal, cleaning evenly mixing device includes cleaning disk, the first driving means for driving cleaning disc spins and pumping device, priming device and evenly mixing device above cleaning disk, and the lifting gear for driving priming device, pumping device and evenly mixing device to move up and down in the vertical direction is additionally provided on pedestal；Evenly mixing device includes for capturing the handgrip of Reagent Tube and driving the second driving device of handgrip rotation；The upper surface of cleaning disk be provided with it is equally distributed put pore, clean in the outer rim of disk the optical inspection hole for being provided with putting pore and being connected；Optical detection apparatus includes being set on pedestal and close to the photon counter of cleaning disk outer rim.The present invention can improve cleaning degree and cleaning efficiency and improve detection efficiency and accuracy in detection.
Description
Technical field
The present invention relates to the field of medical instrument technology, and in particular to a kind of Full-automatic chemiluminescence immunoassay analysis meter.
Background technology
Chemiluminescence immunoassay technology (Chemiluminescence immunoassay, abbreviation CLIA) is current generation
Develop very fast on-radiation immuno analytical method within the scope of boundary, have high sensitivity, high specificity, the range of linearity it is wide,
The advantageous features such as the degree of automation height, it has also become the main means of clinical diagnosis.
Most of Full-automatic chemiluminescence analyzers are generally by manipulator or chain type transmission mechanism, reagent sample currently on the market
Product part incubates the compositions such as part, cleaning part, the detection structure that shines.In detection process, in general, Reagent Tube is loaded this, adds
The gripping of sample reaction tube is transferred to cleaning position after the completion of incubation by magnetic bead, reagent adding by manipulator, is carried out Magneto separate, cleaning, is mixed
Even, note luminous substrate, then luminous check bit is transferred to by transmission mechanism and is detected.Wherein, the cleaning of Reagent Tube and reagent
Blending process has most direct influence, cleaning and being not thorough for mixing often to cause illumination effect or not
The problems such as stabilization, testing result is distorted.One detection process needs to carry out repeatedly transfer operation, sample by manipulator crawl reaction tube
This reaction tube is the problems such as often there is the excessive loss of temperature and energy in transfer and reaction is not thorough in the process, in some instances it may even be possible to wrong
Optimal luminescent detection opportunity is spent, causes test result error larger or the problems such as testing result is unstable；In addition, reaction tube is excessive
Crawl, placement action easily cause test reliability and testing efficiency reduce the problem of.
Invention content
The present invention provides one kind and can improve cleaning degree and cleaning efficiency and improve detection efficiency and detection accurately
The Full-automatic chemiluminescence immunoassay analysis meter of degree.
In order to solve the above technical problems, present invention offer technical solution is as follows：
A kind of Full-automatic chemiluminescence immunoassay analysis meter, including pedestal, be provided on the pedestal cleaning evenly mixing device and
Optical detection apparatus, wherein：
The cleaning evenly mixing device includes the cleaning disk being set on the pedestal, for driving the cleaning disc spins
First driving means and pumping device, priming device and evenly mixing device above the cleaning disk, on the pedestal also
It is provided with the lifting gear for driving the priming device, pumping device and evenly mixing device to move up and down in the vertical direction；
The pumping device, priming device and evenly mixing device difference at least two；
The evenly mixing device includes for capturing the handgrip of Reagent Tube and driving the second driving device of the handgrip rotation；
The upper surface of the cleaning disk be provided with it is equally distributed put pore, be provided in the outer rim of the cleaning disk and institute
It states and puts the optical inspection hole that pore is connected；
The optical detection apparatus includes being set on the pedestal and close to the photon counting of the cleaning disk outer rim
Device.
Further, the lifting gear includes the first spiral lift being set on the pedestal and is set to described
First hoistable platform of the output end of the first spiral lift, first hoistable platform are located at the top of cleaning disk, the pumping
Liquid device, priming device and evenly mixing device are arranged on first hoistable platform.
Further, the first guider, institute are additionally provided between first spiral lift and the first hoistable platform
It states the first guider and uses guide rail slide block transmission mechanism, Worm and worm-wheel gearing or rack and pinion drive mechanism.
Further, the shaft being fixedly connected with the handgrip is provided on the pedestal, between the shaft and pedestal
It is connected using rolling bearing, second driving device includes the first motor being set on first hoistable platform, setting
The first driving wheel in the output end of the first motor and the first driven wheel for being fixedly connected with the shaft, first master
Using the first transmission band connection between driving wheel and the first driven wheel.
Further, the handgrip is made of flexible casing, is uniformly arranged in the lower end outer rim of described sleeve pipe
There is the open slot being connected to the inner wall of described sleeve pipe.
Further, the bottom end of described sleeve pipe is provided with conical opening.
Further, the end face of the shaft is provided with first through hole, is provided in the first through hole and shaft gap
The push pipe set of cooperation, is additionally provided with pipe pressing device on first hoistable platform, and the pipe pressing device includes being set to described the
The second spiral lift on one hoistable platform and the second hoistable platform being connect with the output end of second elevator, it is described
The pressure pipe piece positioned at push pipe set top is provided on second hoistable platform.
Further, the injection needle of the handgrip and priming device is coaxially disposed, and the injection needle is arranged in the push pipe
The endoporus of set.
Further, it is provided with the second guider between first hoistable platform and the second hoistable platform；
Second guider includes guide rod, is provided on second hoistable platform and matches with the guide rod gap
The guide sleeve of conjunction；
Alternatively, second guider uses guide rail slide block transmission mechanism, Worm and worm-wheel gearing or gear teeth
Strip transmission mechanism.
Further, it is provided with Electric radiant Heating Film on the inner wall of the cleaning disk, is provided on the pedestal and adds for cleaning solution
The pipeline heating structure of heat and the luminous substrate heating structure heated for luminous substrate.
Compared with prior art, the invention has the advantages that：
At least two drawing liquid dresses are respectively set in the Full-automatic chemiluminescence immunoassay analysis meter of the present invention above cleaning disk
It sets, priming device and evenly mixing device, and optical detection apparatus is being set close to the position of cleaning disk outer rim.One of fluid injection dress
The injection with evenly mixing device for substrate and mixing are set, remaining pumping device, priming device and evenly mixing device are used for Reagent Tube
Cleaning.First driving means can control the Reagent Tube that cleaning disc spins certain angle to clean in disk and reach corresponding take out
Cleaning mixing is carried out below liquid device, priming device (evenly mixing device), and carries out bottom in the lower section of the last one priming device
Object fills and mixing.The Reagent Tube that last first driving means control cleaning disc spins certain angle to clean in disk reaches light
The corresponding position of detection device is learned, by optical detection apparatus through the optical inspection hole in cleaning disk outer rim to anti-in Reagent Tube
Object is answered to be detected.In the Full-automatic chemiluminescence immunoassay analysis meter of the present invention, by the way that evenly mixing device, and evenly mixing device is arranged
Handgrip and the injection needle of priming device be coaxially disposed, increase to the rotation mixing step of Reagent Tube in cleaning reagent pipe, carry
The high cleaning degree and cleaning efficiency of Reagent Tube.In addition, the present invention is by the way that optical detection apparatus to be positioned close to clean
The position of disk outer rim, and be arranged in the outer rim of cleaning disk with the optical inspection hole putting pore and be connected, the reagent in reagent disc
Pipe need to only rotate a certain angle under the control of first driving means reaches optical detection position, by optical detection apparatus
The optical inspection hole that photon counter is directly based upon on cleaning disk carries out photon reading detection, avoids Reagent Tube and is filled in substrate
The mobile energy expenditure generated and transfer error afterwards, and there is no cross contamination risk, photon error in reading is reduced, is improved
Detection efficiency and accuracy in detection, ensure that the reliability of testing result.
Description of the drawings
Fig. 1 is the structural schematic diagram of the Full-automatic chemiluminescence immunoassay analysis meter of the present invention；
Fig. 2 is the bottom substance schematic diagram of the Full-automatic chemiluminescence immunoassay analysis meter of the present invention；
Fig. 3 be the present invention Full-automatic chemiluminescence immunoassay analysis meter in clean evenly mixing device structural schematic diagram；
Fig. 4 be the present invention Full-automatic chemiluminescence immunoassay analysis meter in evenly mixing device structural schematic diagram.
Specific implementation mode
To keep the technical problem to be solved in the present invention, technical solution and advantage clearer, below in conjunction with attached drawing and tool
Body embodiment is described in detail.
The present invention provides a kind of Full-automatic chemiluminescence immunoassay analysis meter, as shown in Figures 1 to 4, including pedestal 1, pedestal
On be provided with cleaning evenly mixing device and optical detection apparatus 10, wherein：
Cleaning evenly mixing device includes the cleaning disk 2 being set on pedestal 1, the first driving for driving cleaning disk 2 to rotate
Device 3 is additionally provided on pumping device 6, priming device 5 and the evenly mixing device 4 cleaned above disk 2, pedestal 1 for driving
The lifting gear 7 that priming device 5, pumping device 6 and evenly mixing device 4 move up and down in the vertical direction；
Pumping device 6, priming device 5 and the difference of evenly mixing device 4 at least two；
Evenly mixing device 4 includes for capturing the handgrip 4-1 of Reagent Tube and driving the second driving device 4- of handgrip 4-1 rotations
2；
The upper surface of cleaning disk 2 be provided with it is equally distributed put pore 2-1, clean in the outer rim of disk 2 and be provided with and put pipe
The optical inspection hole 2-2 that hole 2-1 is connected；
Optical detection apparatus 10 includes being set on pedestal 1 and close to the photon counter 10-1 of cleaning 2 outer rim of disk.
In the Full-automatic chemiluminescence immunoassay analysis meter of the present invention, when initial position, lifting gear 7 control pumping device 6,
Priming device 5 and evenly mixing device 4 rise the top for making it be fully located at cleaning disk 2.Wait that the Reagent Tube after incubating passes through machinery
Hand is put into after cleaning disk 2, and the control cleaning disk 2 of first driving means 3 rotates by a certain angle so that Reagent Tube reaches pumping device 6
Lower section, at this time lifting gear 7 control 6 time general who has surrendered's Reagent Tubes of pumping device in waste liquid extraction, later lifting gear 7 control pumping
Liquid device 6 rises, and first driving means 3 control cleaning disk 2 and rotate by a certain angle so that Reagent Tube reaches 5 He of priming device again
The lower section of evenly mixing device 4, lifting gear 7 controls priming device 5 at this time and evenly mixing device 4 declines, and priming device 5 is into Reagent Tube
Cleaning solution is injected, the handgrip 4-1 of evenly mixing device 4 captures Reagent Tube, and lifting gear 7 controls priming device 5 and evenly mixing device 4 later
Rise so that Reagent Tube is detached from cleaning disk 2 and puts pore 2-1, rear drive equipment control handgrip 4-1 rotations, Reagent Tube grabbing
The lower rotation of crawl effect of hand 4-1, thus completes the mixing cleaning in Reagent Tube, improves the cleaning degree of Reagent Tube.
After Reagent Tube cleans, the driving cleaning disk 2 of first driving means 3 turns an angle so that Reagent Tube reaches another drawing liquid dress
Set 6 lower section, elevating mechanism drives pumping device 6 to decline the waste liquid extracted in Reagent Tube, rear lifting mechanism driving drawing liquid dress
6 risings are set, the driving cleaning disk 2 of first driving means 3 turns an angle so that Reagent Tube reaches under another priming device 5
Side, elevating mechanism drive priming device 5 to decline, and priming device 5 injects substrate into Reagent Tube, and the handgrip 4-1 of evenly mixing device 4 is grabbed
Reagent Tube is taken, lifting gear 7 controls priming device 5 later and evenly mixing device 4 rises so that Reagent Tube is detached from putting for cleaning disk 2
Pore 2-1, rear drive equipment control handgrip 4-1 rotation, Reagent Tube rotates under the crawl effect of handgrip 4-1, thus completes
Mixing work of the substrate in Reagent Tube.The cleaning disk 2 of the driving of first driving means 3 later turns an angle so that Reagent Tube arrives
Up to 10 corresponding position of optical detection apparatus, the reactant in Reagent Tube is detected by optical detection apparatus 10.
To sum up, Full-automatic chemiluminescence immunoassay analysis meter of the invention is by being arranged evenly mixing device 4, and evenly mixing device 4
The injection needle of handgrip 4-1 and priming device 5 be coaxially disposed, cleaning solution and luminous bottom are injected into Reagent Tube in priming device 5
Reagent Tube is rotated by evenly mixing device 4 after object so that cleaning solution can adequately clean Reagent Tube, Reagent Tube
Cleaning it is more thorough, cleaning efficiency also improves therewith；And by the mixing function of evenly mixing device 4, accelerate luminous substrate
Chemical reaction in Reagent Tube.In addition, the present invention cleans the position of 2 outer rim of disk by the way that optical detection apparatus 10 to be positioned close to
It sets, after the control cleaning disk 2 of first driving means 3 rotates by a certain angle, you can the Reagent Tube that luminous substrate is added will be cleaned in disk 2
It is transferred to optical detection position, the photon counter 10-1 of optical detection apparatus 10 is through the optical inspection hole 2-2 of cleaning disk 2
Count detection can be carried out to the luminous substrate in Reagent Tube, thereby reduce after Reagent Tube is added in luminous substrate and move to optical detection
The distance at position avoids Reagent Tube and generates energy expenditure during the transfers such as crawl, placement, improves detection efficiency, contract
The error of small photon reading, ensure that testing result.
In one embodiment of the invention, the mode that motor driving transmission belt may be used in first driving means 3 drives cleaning disk 2
Rotation, specifically, as shown in Fig. 2, first driving means 3 may include the first motor 3-1 being fixed on pedestal 1, with
The first driving pulley 3-2 that the output end of first motor 3-1 is fixedly connected and the first driven pulley being fixedly connected with cleaning disk 2
3-4 uses the first transmission belt 3-3 connections between the first driving pulley 3-2 and the first driven pulley 3-4.Here the first transmission
The structure type of synchronous belt may be used to improve the transmission accuracy of first driving means 3 with 3-3.
Certainly, first driving means 3 can also use motor to drive other than driving the structure type of transmission belt using motor
Moving gear engagement frame mode come realize its to clean disk 2 rotation control.
In addition, the Reagent Tube after incubating is put into before cleaning disk 2, a certain pore 2-1 of putting of control cleaning disk 2 is needed to arrive
Up to specified position, in order to which Reagent Tube is put into pore 2-1.Determining that this puts whether pore 2-1 reaches specified position,
It may be used and be arranged the first optoelectronic switch 3-5's and the first optoelectronic switch baffle 3-6 on pedestal 1 and the first driven pulley 3-4
Structure type.When needs are to when putting placement Reagent Tube in pore 2-1, first motor 3-1 the first driving pulleys of control 3-2 rotates,
Cleaning disk 2 is driven to rotate from there through the first driven pulley 3-4, when the first optoelectronic switch 3-5 enters the first optoelectronic switch baffle
When the sensed position of 3-6, the first optoelectronic switch 3-5 transmits the signal to the control system of Full-automatic chemiluminescence immunoassay analysis meter
System, control system control first motor 3-1 according to the signal and stop operating, this is put pore 2-1 and reaches specified position, it
Reagent Tube can be put into this to put pore 2-1 subsequent clear to carry out by other mechanisms of Full-automatic chemiluminescence immunoassay analysis meter afterwards
It washes, detect work.
In one embodiment of the invention, optical detection apparatus 10 is outer in order to reduce other than including photon counter 10-1
Barn door 10-2 can be respectively set in the both sides of photon counter 10-1 in influence of portion's light source to the luminous substrate in Reagent Tube
Light source is blocked.
In one embodiment of the invention, the structure type of spiral lift may be used to control pumping device in lifting gear 7
6, the lifting of priming device 5 and evenly mixing device 4 relative to cleaning disk 2.Specifically, lifting gear 7 preferably includes to be set to pedestal 1
On the first spiral lift 7-1 and be set to the first spiral lift 7-1 output end the first hoistable platform 7-2, first
Hoistable platform 7-2 is located at the top of cleaning disk 2, and it is flat that pumping device 6, priming device 5 and evenly mixing device 4 are arranged at the first lifting
On platform 7-2.When the first spiral lift 7-1 energization rotation and liftings, pumping device 6, fluid injection are controlled by the first hoistable platform 7-2
Device 5 and evenly mixing device 4 lift simultaneously.
Wherein, pumping device 6 may include liquid pumping needle 6-1 and the liquid pumping needle that is fixedly connected on the first hoistable platform 7-2
Bearing 6-2, liquid pumping needle 6-1 are fixed on by fastening screw on liquid pumping needle bearing 6-2.When the first hoistable platform 7-2 is in the first spiral shell
When being lifted under the control of rotation elevator 7-1, it is dynamic that liquid pumping needle 6-1 can carry out drawing liquid relative to the Reagent Tube lifting in cleaning disk 2
Make.
Priming device 5 can also be including injection needle 5-1 and the injection needle bearing being fixedly connected on the first hoistable platform 7-2
5-2, injection needle 5-1 are fixed on injection needle bearing 5-2.When the first hoistable platform 7-2 is in the control of the first spiral lift 7-1
When lower lifting, injection needle 5-1 can carry out fluid injection action relative to the Reagent Tube lifting in cleaning disk 2.
During the present invention one is implemented, the quantity of pumping device 6, priming device 5 and evenly mixing device 4 is respectively three, annular cloth
It sets on the first hoistable platform 7-2,6, priming devices 5 of a pumping device and an evenly mixing device 4 form a set of mixing
Structure, wherein two sets of mixing structures are used for the cleaning of Reagent Tube, and last a set of mixing structure is used for the injection of luminous substrate and mixes
It is even.The present invention further improves the cleaning of Reagent Tube by the way that more set mixing structures are arranged by the way that Reagent Tube is cleaned multiple times
Degree, and luminous substrate directly is injected to Reagent Tube in cleaning disk 2 after Reagent Tube cleans, Reagent Tube is avoided in crawl, shifting
Cross contamination is generated during sending, and improves accuracy of detection.
In one embodiment of the invention, the outer fringe position on pedestal 1 close to cleaning disk 2 is additionally provided with multiple strong magnetic devices 9, often
A pumping device 6, priming device 5 and evenly mixing device 4 correspond to one strong magnetic device 9 respectively.When cleaning disk 2 rotate by a certain angle by
When Reagent Tube is transferred to the lower section of pumping device 6, priming device 5 and evenly mixing device 4, the magnetic bead in Reagent Tube is based on strong magnetic device
9 magnetism, is attracted on the inner wall of Reagent Tube, ensures that the liquid pumping needle 6-1 of pumping device 6 will not extract magnetic bead out in drawing liquid
Reagent Tube.
Preferably, in order to improve stability of the first hoistable platform 7-2 in lifting process, the first spiral lift 7-1
It is also provided with the first guider 7-3, the first guider 7-3 between the first hoistable platform 7-2, guide rail may be used
Any structure form in slider driving gear, Worm and worm-wheel gearing and rack and pinion drive mechanism, may be implemented pair
The guiding role of first hoistable platform 7-2.
When the first guider 7-3 uses the form of guide rail slide block transmission mechanism, the first guider 7-3 is preferably included
The guide rail being set on pedestal 1 and the sliding block for being set to the output end of the first spiral lift 7-1 and being slidably connected with guide rail.
In addition, when pumping device 6, priming device 5 and evenly mixing device 4 decline under the control of the first spiral lift 7-1,
Liquid pumping needle 6-1, injection needle 5-1 and handgrip 4-1 decline in order to prevent height is too low to damage Reagent Tube, can be in guide rail
With the second optoelectronic switch 7-5 and the second optoelectronic switch baffle 7-4 are respectively set on sliding block.When the first spiral lift 7-1 drives
Pumping device 6, priming device 5 and evenly mixing device 4 decline so that liquid pumping needle 6-1, injection needle 5-1 and handgrip 4-1 are reached suitably
When height, when the second optoelectronic switch 7-5 enters the sensed position of the second optoelectronic switch baffle 7-4, Full-automatic chemiluminescence is immune
Under the control system of analyzer stops according to the signal of the second optoelectronic switch 7-5 received the first spiral lift of control 7-1
Drop, pumping device 6, priming device 5 and evenly mixing device 4 carry out corresponding drawing liquid, fluid injection and mixing action later.
In one embodiment of the invention, pumping device 6, priming device 5 and evenly mixing device 4 are fixedly connected sequentially in the first lifting
On platform 7-2, wherein injection needle 5-1 and handgrip 4-1 can both correspond to two and put pore 2-1 respectively, and injection needle 5-1 is to Reagent Tube
After middle fluid injection, priming device 5 is controlled by lifting gear 7 and is risen, the cleaning disk 2 of the control of first driving means 3 later rotates centainly
Angle makes the lower section of Reagent Tube arrival handgrip 4-1, and lifting gear 7 controls the decline of evenly mixing device 4 and caught by handgrip 4-1 again later
Reagent Tube carries out mixing action.
Other than above structure mode, injection needle 5-1 and handgrip 4-1 can also be coaxially disposed and put pipe so that correspondence is same
Hole 2-1.Specifically, handgrip 4-1 can be connect by shaft 4-3 with pedestal 1, and the axis of rolling is used between shaft 4-3 and pedestal 1
4-4 connections are held, it is possible thereby to ensure that handgrip 4-1 can be rotated relative to its axis.At this point, use need to be arranged in the end face of shaft 4-3
In the first through hole of the injection needle 5-1 across priming device 5, the second driving device 4-2 can also use motor driven belts wheel
Frame mode controls handgrip 4-1 rotations, specifically, the second driving device 4-2 may include being set on the first hoistable platform 7-2
The second motor 4-2-1, the second driving wheel 4-2-2 for being connect with the output end of the second motor 4-2-1 and being fixed with shaft 4-3 connect
The the second driven wheel 4-2-4 connect is connected between the second driving wheel 4-2-2 and the second driven wheel 4-2-4 using the second transmission belt 4-2-3
It connects.
Further, since there is multiple Reagent Tubes and mixing mechanism in cleaning disk 2, multiple Reagent Tubes can be carried out at the same time clearly
Wash mixing.Under this structure type, in order to reduce cost, changes hands for adjacent two and a second motor 4-2-1 may be used
It is driven, specifically, the second transmission belt 4-2-3 can connect the second driving wheel 4-2-2 and two the second driven wheel 4- simultaneously
2-4, after the second motor 4-2-1 starts work, the second driving wheel 4-2-2 drives two by driving the second transmission belt 4-2-3
Second driven wheel 4-2-4 rotations, rotate while being achieved in two handgrip 4-1.
Further, handgrip 4-1 is preferably made of flexible casing, is evenly arranged in the lower end outer rim of casing
The open slot 4-1-1 being connected to the inner wall of casing.When declining under controls of the handgrip 4-1 in lifting gear 7, due to the bullet of casing
Property effect and open slot 4-1-1 setting, the upper end of Reagent Tube is directly inserted into the inner wall of casing, is fixed on casing later
Endoporus in.
Preferably, when lifting gear 7 drives handgrip 4-1 to decline, in order to make the more smooth sleeve pipe in the upper end of Reagent Tube
The bottom end of endoporus, casing can be provided with conical opening, and the lower end diameter of the conical opening is more than the diameter of bore of casing.
After evenly mixing device 4 is to the liquid blending in Reagent Tube, lifting gear 7 controls general who has surrendered's Reagent Tube under handgrip 4-1 and puts
It is back to and puts pore 2-1, since handgrip 4-1 cannot individually complete the function that Reagent Tube is returned to pore 2-1, pressure pipe is needed to fill
11 mate-assists are set to take out Reagent Tube from handgrip 4-1.Specifically, can be arranged in the first through hole of shaft 4-3 and turn
The push pipe of axis 4-3 clearance fits covers 4-5, and pipe pressing device 11 is arranged on the first hoistable platform 7-2, and pipe pressing device 11 preferably includes
It the second spiral lift 11-1 for being set on the first hoistable platform 7-2 and is connect with the output end of the second spiral lift 11-1
The second hoistable platform 11-2, the second hoistable platform 11-2 on be provided with positioned at push pipe set 4-5 above pressure pipe piece 11-3.When
When two spiral lift 11-1 control declines of the second hoistable platform 11-2 with dynamic pressure tube piece 11-3, pressure pipe piece 11-3 and push pipe set
The upper-end contact of 4-5 simultaneously pushes push pipe set 4-5 to move downward, and after push pipe set 4-5 moves downward certain distance, push pipe covers 4-5's
The upper end of lower end in contact Reagent Tube, when pressure pipe piece 11-3 continues to move downward, Reagent Tube moves back under the impetus that push pipe covers 4-5
The endoporus for going out casing drops down onto and puts pore 2-1, and handgrip 4-1 rises under the drive of lifting gear 7 later, thus completes Reagent Tube
It places.
In addition, can also include being respectively arranged at the first hoistable platform 7-2 and the second hoistable platform 11- on pipe pressing device 11
Third optoelectronic switch baffle 11-6 on 2 and third optoelectronic switch baffle 11-6 baffles, when the second spiral lift 11-1 controls
When second hoistable platform 11-2 drops to certain height relative to the first hoistable platform 7-2, third optoelectronic switch baffle 11-6
Into third photoswitc baffle sensed position when, the control system of Full-automatic chemiluminescence immunoassay analysis meter is according to receiving
The second spiral lift 11-1 of signal control of third optoelectronic switch baffle 11-6 stop declining, pressure pipe piece 11-3 can be prevented
Reagent Tube is crushed because falling head is too low.
Likewise, the second spiral lift 11-1 is when controlling the second hoistable platform 11-2 lifting, in order to improve second liter
Stability of the platform 11-2 in lifting process drops, between the second spiral lift 11-1 and the second hoistable platform 11-2 it is also preferred that
It is provided with the second guider 11-4, the second guider 11-4 and guide rail slide block transmission mechanism, Worm Wheel System may be used
Any structure form in mechanism and rack and pinion drive mechanism may be implemented to make the guiding of the second hoistable platform 11-2
With.
Certainly, as shown in figure 3, the second guider 11-4 can also use the structure side of guide rod and guide sleeve cooperation
Formula, wherein guide sleeve can be set on the first hoistable platform 7-2, be arranged on the second hoistable platform 11-2 and match with guide sleeve gap
The guide rod of conjunction.
In one embodiment of the invention, in order to avoid shadow of the Reagent Tube in cleaning disk 2 during transfer by temperature change
It rings, and then leads to the inaccuracy of testing result, Electric radiant Heating Film such as PI Electric radiant Heating Films, electric heating can be set on the inner wall of cleaning disk 2
The setting of film can be used for simulating human body temperature, ensure that Reagent Tube is not acted upon by temperature changes.
Further, it is also possible to which setting is for the pipeline heating structure 8 of cleaning solution heating and for substrate heating on pedestal 1
Luminous substrate heating structure.Wherein pipeline heating structure 8 is identical with luminous substrate heating structure, includes heating inner core and heating
Outer wall, for heating inner core for fixing pipeline and heat conduction, heating outer wall is provided with Electric radiant Heating Film, and is surrounded by heat-preservation cotton.Pipeline heating knot
Structure 8 and luminous substrate heating structure are separately fixed at by using end cap made of POM materials on pedestal 1, ensure that thermal insulation,
Improve the efficiency of heating surface.
In conclusion the Full-automatic chemiluminescence immunoassay analysis meter of the present invention is by multistep cleaning, mixing and optical detection three
Kind function set is integrated system, reduces the structural complexity of analyzer, improves structural reliability, and reduces analysis
The whole manufacturing cost of instrument；The multistep cleaning of the present invention, blending manner ensure that cleaning performance, can be carried out at the same time multiple reagents
Cleaning, the mixing action of pipe, improve the reaction speed of cleaning efficiency and luminous substrate；The structure type of integral system avoids
Reagent Tube generates transfer error and energy expenditure during transfer, and does not have cross contamination, reduces photon reading and misses
Difference improves testing efficiency, ensure that the reliability of testing result.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, without departing from the principles of the present invention, it can also make several improvements and retouch, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of Full-automatic chemiluminescence immunoassay analysis meter, including pedestal, which is characterized in that it is mixed to be provided with cleaning on the pedestal
Even device and optical detection apparatus, wherein：
The cleaning evenly mixing device includes the cleaning disk being set on the pedestal, first for driving the cleaning disc spins
Driving device and pumping device, priming device and evenly mixing device above the cleaning disk, also set up on the pedestal
It is useful for the lifting gear for driving the priming device, pumping device and evenly mixing device to move up and down in the vertical direction；
The pumping device, priming device and evenly mixing device difference at least two；
The evenly mixing device includes for capturing the handgrip of Reagent Tube and driving the second driving device of the handgrip rotation；
The upper surface of the cleaning disk be provided with it is equally distributed put pore, be provided in the outer rim of the cleaning disk and put with described
The optical inspection hole that pore is connected；
The optical detection apparatus includes being set on the pedestal and close to the photon counter of the cleaning disk outer rim.
2. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that the lifting gear includes
First lifting of the first spiral lift being set on the pedestal and the output end for being set to first spiral lift
Platform, first hoistable platform are located at the top of cleaning disk, and the pumping device, priming device and evenly mixing device are arranged at
On first hoistable platform.
3. Full-automatic chemiluminescence immunoassay analysis meter according to claim 2, which is characterized in that first spiral lifting
The first guider is additionally provided between machine and the first hoistable platform, first guider uses guide rail slide block driver
Structure, Worm and worm-wheel gearing or rack and pinion drive mechanism.
4. according to any Full-automatic chemiluminescence immunoassay analysis meter in claims 1 to 3, which is characterized in that the bottom
It is provided with the shaft being fixedly connected with the handgrip on seat, is connected using rolling bearing between the shaft and pedestal, described the
Two driving devices include the first motor being set on first hoistable platform, the output end for being set to the first motor
First driving wheel and the first driven wheel being fixedly connected with the shaft, use between first driving wheel and the first driven wheel
First transmission band connection.
5. Full-automatic chemiluminescence immunoassay analysis meter according to claim 4, which is characterized in that the handgrip, which uses, to be had
The casing of elasticity is made, and the open slot being connected to the inner wall of described sleeve pipe is evenly arranged in the lower end outer rim of described sleeve pipe.
6. Full-automatic chemiluminescence immunoassay analysis meter according to claim 5, which is characterized in that the bottom end of described sleeve pipe is set
It is equipped with conical opening.
7. Full-automatic chemiluminescence immunoassay analysis meter according to claim 4, which is characterized in that the end face of the shaft is set
It is equipped with first through hole, the push pipe set with shaft clearance fit is provided in the first through hole, is gone back on first hoistable platform
Be provided with pipe pressing device, the pipe pressing device include the second spiral lift being set on first hoistable platform and with institute
The second hoistable platform of the output end connection of the second elevator is stated, is provided with positioned at the push pipe set on second hoistable platform
The pressure pipe piece of top.
8. Full-automatic chemiluminescence immunoassay analysis meter according to claim 7, which is characterized in that the handgrip is filled with fluid injection
The injection needle coaxial arrangement set, the injection needle are arranged in the endoporus of the push pipe set.
9. Full-automatic chemiluminescence immunoassay analysis meter according to claim 8, which is characterized in that first hoistable platform
The second guider is provided between the second hoistable platform；
Second guider includes guide rod, is provided on second hoistable platform and the guide rod clearance fit
Guide sleeve；
Alternatively, second guider is passed using guide rail slide block transmission mechanism, Worm and worm-wheel gearing or rack-and-pinion
Motivation structure.
10. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that described to clean the interior of disk
It is provided with Electric radiant Heating Film on wall, the pipeline heating structure heated for cleaning solution is provided on the pedestal and adds for luminous substrate
The luminous substrate heating structure of heat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810820822.2A CN108732163B (en) | 2018-07-24 | 2018-07-24 | Full-automatic chemiluminescence immunoassay instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810820822.2A CN108732163B (en) | 2018-07-24 | 2018-07-24 | Full-automatic chemiluminescence immunoassay instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108732163A true CN108732163A (en) | 2018-11-02 |
| CN108732163B CN108732163B (en) | 2024-08-16 |
Family
ID=63926944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810820822.2A Active CN108732163B (en) | 2018-07-24 | 2018-07-24 | Full-automatic chemiluminescence immunoassay instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108732163B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109596528A (en) * | 2018-12-11 | 2019-04-09 | 迪瑞医疗科技股份有限公司 | A kind of automatic coagulation analyzer and its analysis method |
| CN109675890A (en) * | 2019-02-20 | 2019-04-26 | 重庆科斯迈生物科技有限公司 | Disc type washing system of chemiluminescence immunoassay analyzer |
| CN110801763A (en) * | 2019-11-09 | 2020-02-18 | 山东博科生物产业有限公司 | Reaction tube grabbing and mixing device and analyzer |
| CN114082734A (en) * | 2021-09-10 | 2022-02-25 | 北京胡曼智造科技有限责任公司 | Cleaning system |
| CN114295853A (en) * | 2021-12-13 | 2022-04-08 | 杭州睿丽科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer and application method thereof |
| CN116818686A (en) * | 2022-12-16 | 2023-09-29 | 广东牧玛生命科技有限公司 | POCT biochemical analyzer |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN204203242U (en) * | 2014-09-30 | 2015-03-11 | 博奥赛斯（天津）生物科技有限公司 | A kind of automatic chemiluminescence immunoassay device |
| CN105445258A (en) * | 2016-01-04 | 2016-03-30 | 泰州泽成生物技术有限公司 | Integrated cleaning and detecting device for chemiluminescence instrument |
| CN105628687A (en) * | 2016-02-24 | 2016-06-01 | 南京诺尔曼生物技术有限公司 | Full-automatic chemiluminiscence tester |
| CN205301342U (en) * | 2015-12-23 | 2016-06-08 | 深圳雷杜生命科学股份有限公司 | Automatic washing, mixing and separator |
| CN207181272U (en) * | 2017-09-28 | 2018-04-03 | 深圳市锦瑞生物科技有限公司 | Magnetic bead cleans separator and immunity analysis instrument automatically |
| CN207636603U (en) * | 2017-12-12 | 2018-07-20 | 深圳拓真生物科技有限公司 | It is incubated cleaning device and immunity analysis instrument |
| CN208588675U (en) * | 2018-07-24 | 2019-03-08 | 山东博科诊断科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
-
2018
- 2018-07-24 CN CN201810820822.2A patent/CN108732163B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN204203242U (en) * | 2014-09-30 | 2015-03-11 | 博奥赛斯（天津）生物科技有限公司 | A kind of automatic chemiluminescence immunoassay device |
| CN205301342U (en) * | 2015-12-23 | 2016-06-08 | 深圳雷杜生命科学股份有限公司 | Automatic washing, mixing and separator |
| CN105445258A (en) * | 2016-01-04 | 2016-03-30 | 泰州泽成生物技术有限公司 | Integrated cleaning and detecting device for chemiluminescence instrument |
| CN105628687A (en) * | 2016-02-24 | 2016-06-01 | 南京诺尔曼生物技术有限公司 | Full-automatic chemiluminiscence tester |
| CN207181272U (en) * | 2017-09-28 | 2018-04-03 | 深圳市锦瑞生物科技有限公司 | Magnetic bead cleans separator and immunity analysis instrument automatically |
| CN207636603U (en) * | 2017-12-12 | 2018-07-20 | 深圳拓真生物科技有限公司 | It is incubated cleaning device and immunity analysis instrument |
| CN208588675U (en) * | 2018-07-24 | 2019-03-08 | 山东博科诊断科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109596528A (en) * | 2018-12-11 | 2019-04-09 | 迪瑞医疗科技股份有限公司 | A kind of automatic coagulation analyzer and its analysis method |
| CN109675890A (en) * | 2019-02-20 | 2019-04-26 | 重庆科斯迈生物科技有限公司 | Disc type washing system of chemiluminescence immunoassay analyzer |
| CN109675890B (en) * | 2019-02-20 | 2024-04-02 | 重庆科斯迈生物科技有限公司 | Disk type chemiluminescent immunoassay analyzer washing system |
| CN110801763A (en) * | 2019-11-09 | 2020-02-18 | 山东博科生物产业有限公司 | Reaction tube grabbing and mixing device and analyzer |
| CN114082734A (en) * | 2021-09-10 | 2022-02-25 | 北京胡曼智造科技有限责任公司 | Cleaning system |
| CN114295853A (en) * | 2021-12-13 | 2022-04-08 | 杭州睿丽科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer and application method thereof |
| CN114295853B (en) * | 2021-12-13 | 2024-08-20 | 杭州睿丽科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer and use method thereof |
| CN116818686A (en) * | 2022-12-16 | 2023-09-29 | 广东牧玛生命科技有限公司 | POCT biochemical analyzer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108732163B (en) | 2024-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108732163A (en) | Full-automatic chemiluminescence immunoassay analysis meter | |
| CN102998473B (en) | Full-automatic chemiluminescence immune analyzer | |
| CN109061210B (en) | Full-automatic luminous chemical immunity analyzer | |
| CN109142768B (en) | Automatic analyzer and sample analyzing method | |
| EP3561515B1 (en) | Automatic analysis device and sample analysis method | |
| CN106199026B (en) | Full-automatic chemiluminescence immunoassay analysis meter | |
| CN103399161B (en) | Portable full-automatic chemiluminescence immune assay system and assay method thereof | |
| WO2018126774A1 (en) | Automatic analysis device and sample analysis method | |
| JP3521142B2 (en) | How to operate reagents by random access method in an automatic analyzer | |
| WO2018126772A1 (en) | Reaction incubation device, immunity analyzer and reaction incubation method | |
| CN108593949A (en) | A kind of chemical illumination immunity analysis instrument | |
| CN106018784A (en) | Small electrochemical luminescence immunoassay analyzer and analysis method thereof | |
| CN208178045U (en) | A kind of automatic cleaning incubation mixing detection system | |
| CN205539017U (en) | Full -automatic portable chemiluminescent immunoassay analysis appearance | |
| CN208721691U (en) | A kind of luminescent chemical immunity analysis instrument | |
| WO2023035258A1 (en) | Sample rack conveying apparatus and analyzer | |
| CN108872078A (en) | A kind of Full-automatic chemiluminescence analyzer | |
| WO2019056234A1 (en) | Automatic analysis apparatus and operating method therefor | |
| CN110045136A (en) | A kind of method of automatic sample machine and automatic sample | |
| CN208588675U (en) | Full-automatic chemiluminescence immunoassay analysis meter | |
| CN201368879Y (en) | Biological test sensor | |
| CN110297101A (en) | The method of the automatic sample machine and automatic sample of sample adding device and pipeline system detection | |
| CN114019178A (en) | Full-automatic immune biochemical integrated analyzer and use method thereof | |
| CN104237546A (en) | Full-automatic chemiluminescence immune assay device | |
| CN101504418B (en) | Bioassay sensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |