CN109675890A - Disc type washing system of chemiluminescence immunoassay analyzer - Google Patents
Disc type washing system of chemiluminescence immunoassay analyzer Download PDFInfo
- Publication number
- CN109675890A CN109675890A CN201910127358.3A CN201910127358A CN109675890A CN 109675890 A CN109675890 A CN 109675890A CN 201910127358 A CN201910127358 A CN 201910127358A CN 109675890 A CN109675890 A CN 109675890A
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- washing
- pedestal
- head
- base
- disc type
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- 238000005406 washing Methods 0.000 title claims abstract description 235
- 238000003018 immunoassay Methods 0.000 title abstract description 4
- 239000000758 substrate Substances 0.000 claims abstract description 25
- 238000010438 heat treatment Methods 0.000 claims abstract description 15
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 69
- 238000009434 installation Methods 0.000 claims description 45
- 238000004458 analytical method Methods 0.000 claims description 18
- 230000036039 immunity Effects 0.000 claims description 17
- 238000005286 illumination Methods 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 14
- 230000005484 gravity Effects 0.000 claims description 11
- 239000011521 glass Substances 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 15
- 238000001514 detection method Methods 0.000 abstract description 13
- 238000004321 preservation Methods 0.000 abstract description 3
- 238000010586 diagram Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 239000006249 magnetic particle Substances 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 3
- 230000002277 temperature effect Effects 0.000 description 3
- 238000005452 bending Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 108010021156 ARC 341 Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a disc type washing system of a chemiluminescence immunoassay analyzer, which comprises a washing base and a washing disc, wherein the washing disc is rotatably arranged on the washing base, cup placing openings are distributed on the washing disc in an annular array manner and are vertically arranged, and a driving motor A for driving the washing disc to rotate is arranged on the washing base; the washing head is movably arranged right above the washing base and can be relatively close to or far away from the washing base, at least one washing needle group and at least one substrate filling needle are vertically arranged on the washing head, and the driving motor B is used for driving the washing head to be close to or far away from the washing base. By adopting the scheme, the whole structure is compact, the occupied space is small, various conception directions are provided for the miniaturization development of the analyzer, and the mode of combining multiple times of washing, suction washing and heat preservation heating washing is adopted, so that the washing effect is greatly improved, and the later-stage detection precision is favorably ensured.
Description
Technical field
The invention belongs to medicinal chemistry luminescence immunoassay detection technique fields, and in particular to a kind of disc type chemiluminescence
Immunity analysis instrument washing system.
Background technique
In immunoassay experiment, generallys use chemiluminescence immune analysis method and body fluid is tested and analyzed, detecting
In the process, experimenter needs to contain body fluid to be detected using dedicated reaction cup, it will usually by filling, mixing, incubating
Educate, wash and detect and etc., wherein being mainly the carry out drug irrigation to the reagent bottle for completing to be incubated in the washing stage, and add
Substrate is infused, and existing washing system transverse direction area occupied is larger, operation is more troublesome, and mode of washing is single, it is difficult to reagent
Bottle is thoroughly washed, and is caused washing effect not good enough, is influenced testing result precision.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of disc type chemical illumination immunity analysis instrument washing system,
Washing operation difficulty is reduced, various ways cooperation washing improves washing effect.
To achieve the above object, technical solution of the present invention is as follows:
A kind of disc type chemical illumination immunity analysis instrument washing system, it is critical that including:
Wash pedestal；
Disk is washed, is set on washing pedestal in a rotatable manner, circular array, which is distributed with, on the washing disk sets rim of a cup,
It is described that set rim of a cup vertically arranged；
Driving motor A is used to that the washing disk to be driven to rotate；
Washing head is movably set in above washing pedestal, and can be relatively close or far from the washing pedestal, washing head
On vertically be equipped at least one washing needle group and at least one substrate fill needle；
Driving motor B is used to drive the washing head close to or far from washing pedestal.
Same reaction cup can repeatedly be washed, by washing the rotary motion of disk to improve using above scheme
Washing effect completes the filling that substrate solution can be accordingly carried out after washing, and washing is filled with substrate and is integrated to a structure
On, the whole circumferential direction space that occupies is smaller, makes full use of height space, is conducive to the area occupied for reducing analyzer platform, and tie
Structure is simple, implements convenient for operation.
As preferred: the position of corresponding washing disk has the installation cavity of upper end opening, the washing on the washing pedestal
Disk and the installation cavity upper end size are adapted, and have the installation base of structure in a ring, the installation base in the installation cavity
Middle part has the mounting hole of setting concentric with it, and the driving motor A is located at immediately below installation base, and vertically upward, electricity
Arbor protrudes into mounting hole to be connected with the washing disk of top.
Using the above structure, it washs in the embeddable installation cavity of disk, the sidewall spacers of outer rim and installation cavity cooperate, and can prevent
By the interference from side, it is advantageously ensured that rotational stability, while driving motor A being arranged in bottom, can further it subtract
Its small system circumferential direction occupied space, makes its more compact structure.
As preferred: the driving motor A is connected by intermediate attachment base with installation base, the upper end of driving motor A and
It is detachably connected that screw is all made of between intermediate attachment base, and between intermediate attachment base and installation base；
The motor shaft of the driving motor A is connected by middle support base with washing disk, and the middle support base is located at peace
It fills in hole, and is solidly set on the motor shaft by stopping head screw, there is annular heavy platform, centre branch on the inside of the intermediate attachment base
Seat structure in T shape is supportted, is embedded with the first thrust ball bearing between the middle support base lower end and the annular heavy platform side wall.
Using above scheme, the assembling of driving motor A is improved, convenient for directly carrying out whole tear open from the lower section of washing pedestal
Dress improves assembly efficiency, is conducive to the maintenance in later period, and can be further ensured that washing disk stability of rotation and fluency,
Prevent liquid in reaction cup from spilling.
As preferred: rotation washing channel annular in shape is formed between the installation base outer wall and installation cavity wall,
Rotation washing channel and the top set that rim of a cup position is corresponding, and circumferentially hand on the two sides side wall for rotating washing channel
Magnetic sheet is distributed in mistake.
The washing channel adopted the structure, when washing, reaction cup along rotation washing channel rotation, in magnetic particle by
The magnetic sheet effect being interspersed to two sides, cooperates using to the mode of suction and multiple mode of washing, is attached to magnetic particle any one
On the side wall of side, magnetic particle can be effectively prevent to be deposited on reaction cup bottom wall, cause solution washing suction in reaction cup unclean, or
Magnetic particle is in and moves freely state, is easy to be sucked away with solution, causes magnetic particle Loss Rate to greatly increase, to the later period
Detection causes adverse effect, therefore can be conducive to rinse suction completely, improves washing effect, it is ensured that late detection inspection with higher
Survey precision.
As preferred: the bottom wall lowest part of the rotation washing channel is equipped with through washing base lower surface from discharge orifice,
And it is configured with and the gravity flow pipe fitting being adapted from discharge orifice.Using the above structure, in washing process, excessive washing is injected
Liquid spills liquid and can converge to lower by the rotation washing channel of lower section, then by being discharged from discharge orifice, avoids to analyzer
Platform impacts.
As preferred: being equipped at least one lifting sliding rail, the washing head and the lifting on the washing pedestal vertically
Sliding rail is slidably matched, and the driving motor B is lead screw motor, and is mounted on washing pedestal, screw rod and the washing head spiral shell
Line cooperation.Using above scheme, the lift adjustment of washing head is realized, structure is simple, and it is convenient to carry out, while driving motor B being pacified
On washing pedestal, mitigate washing head weight, is conducive to the consumption power for reducing driving motor B, and motor is in fixing shape
State, pipeline are easier to mounting arrangements, run more stable.
As preferred: the position of face washing disk has the recessing groove in arc-shaped on the washing head, the recessing groove
Front side is open, and the washing needle group and substrate filling needle are distributed along the outer rim of recessing groove, and are compressed by pressing plate.More than
Structure, handgrip completion of being more convenient for put cup and cup are taken to act, while can ensure that stability and the bottom of washing needle group and substrate filling needle
The reasonability of object filling.
As preferred: it is described washing pedestal bottom have ABS thermal insulation board, the ABS thermal insulation board and washing pedestal under
Between the surface and lower surface of washing head is equipped with heating device, and the top for washing pedestal and washing head is equipped with temperature
Sensor.Using the above structure, it can be ensured that the cleaning solution and substrate of addition and the reaction cup on washing pedestal are in
The environment of opposite heat preservation, preferably controls washing process temperature, weakens ambient temperature effect, is conducive to improve late detection essence
Degree.
As preferred: the heating device is heat tape, wriggles in the washing head and chase, the pipeline is distributed with
Slot runs through the upper surface of washing head, and the upper surface of the washing head is covered with metal cover board.Using above scheme, it is easily installed cloth
Feed liquor pipeline is set, installation difficulty is reduced, while by the space of relative closure, heating accumulation of heat effect is improved, to improve to place
In the heating and thermal insulation effect of chase gut line.
As preferred: the front side of the washing pedestal is equipped at least one cup holder mounting hole, in the cup holder mounting hole with
It has been rotatably installed cup holder, there is a vertically arranged and open upper end glass chamber of setting in the cup holder, wash and configured on pedestal
There is the mixing motor to drive the cup holder rotation.Mixing mechanism is directly integrated on washing pedestal, is conducive to shorten handgrip
Moving distance reduces whole occupied space, is advantageously implemented the miniaturization of analyzer to simplify gripping structure.
Compared with prior art, the beneficial effects of the present invention are:
Using disc type chemical illumination immunity analysis instrument washing system provided by the invention, compact overall structure is occupied
Space is few, provides a variety of design directions for the miniaturization of analyzer, and wash, to suction washing and heat preservation using multiple
The mode that heating washing combines, substantially increases washing effect, advantageously ensures that the detection accuracy in later period.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is the rear structure schematic diagram of embodiment illustrated in fig. 1；
Fig. 3 is the lower structure schematic diagram of embodiment illustrated in fig. 1；
Fig. 4 is washing schematic diagram of base structure；
Fig. 5 is installation cavity structural schematic diagram on washing pedestal；
Fig. 6 is the schematic diagram of the section structure of embodiment illustrated in fig. 1；
Fig. 7 is rotation washing channel structural schematic diagram；
Fig. 8 is inner convex platform structural schematic diagram；
Fig. 9 is outer lug boss structural schematic diagram；
Figure 10 is washing base vertical view；
Figure 11 is sectional view along A-A in Figure 10；
Figure 12 is B-B direction cross-sectional view in Figure 10；
Figure 13 is washing head structural schematic diagram；
Figure 14 is washing head superstructure schematic diagram；
Figure 15 is washing head overlooking structure diagram.
Specific embodiment
The invention will be further described with attached drawing with reference to embodiments.
Referring to figs. 1 to disc type chemical illumination immunity analysis instrument washing system shown in figure 15, main includes substantially being in
The washing pedestal 1 and washing head 3 and washing disk 2 in the form of annular discs of square plate, as shown, close to middle part on washing pedestal 1
Position be equipped with the installation cavity 10 in hollow columnar structures, and the upper end of installation cavity 10 is open, washing disk 2 can be rotatably set with
Installation cavity 10, upper surface are flushed with the upper edge of installation cavity 10 substantially.
With reference to Fig. 2, fig. 4 to fig. 6, wash on pedestal 1 configured with the driving motor A1a to drive washing disk 2 to rotate, peace
Behave affectedly in 10 with the installation bases 11 of setting concentric with it, in the present embodiment, installation base 11 and 1 one of washing pedestal at
Type, the bottom wall of 11 self installation chamber 10 of installation base is raised upward vertically, the interior mounting hole 12 with setting concentric with it, installation
Hole 12 is the through-hole structure through washing pedestal 1, and driving motor A1a is located at the underface of mounting hole 12, and its motor shaft vertical
Upward, and by intermediate attachment base 13 with washing pedestal 1 it is connected, as shown, the shape and driving motor of intermediate attachment base 13
The upper end A1a is adapted, and is directly connected with installation base 11 by screw, and between intermediate attachment base 13 and driving motor A1a
It is connected also by screw, it in this way can be more convenient for from below by the installation of driving motor A1a integral demounting.
The motor shaft of driving motor A1a protrudes into mounting hole 12, and is arranged with a middle support base 14, and by stopping head
Screw locks the two, and the size and mounting hole 12 of middle support base 14 are adapted, clearance fit between the two, and wash disk 2
It is then detachably connected by screw downwards with middle support base 14, increases the bearing area of washing disk 2 in this way, thus
Be conducive to improve stationarity when its rotation, be certainly the raising washing rotation fluency of disk 2, therefore in middle support base 14 and centre
The first thrust ball bearing 1a0 is equipped between attachment base 13, as shown, the inside of intermediate attachment base 13 has annular heavy platform, and
The cylinder step structure substantially in T shape of middle support base 14, the two are coaxially disposed centered on the motor shaft of driving motor A1a,
And the diameter of 14 lower end of middle support base is less than the diameter of annular heavy platform on intermediate attachment base 13, allows for annular heavy platform in this way
There is gap, the first thrust ball bearing 1a0 is then in the gap, and intermediate between 14 bottom side of the wall of side wall and middle support base
There are gap, the lower end of the first thrust ball bearing 1a0 and annular heavy platform bottoms between the lower end of support base 14 and annular heavy platform bottom wall
Wall abuts, and the lower end of middle support base 14 is protruded into the inner ring of the first thrust ball bearing 1a0.
With reference to Fig. 1, Fig. 4 and Figure 10, circular array is distributed with several and sets rim of a cup 20 on washing disk 2, and it is perpendicular to set rim of a cup 20
To setting and its upper and lower open at both ends, the upper end and common reaction cup superstructure are adapted, and can be put into reaction cup, and
Stablize to hang on and set at rim of a cup 20, there is rotation washing channel 1c in the position of just opposed rim of a cup 20 in installation cavity 10, rotation is washed
Channel 1c substantially structure in a ring is washed, and is arranged concentrically with washing disk 2, when reaction cup, which is hung on, sets in rim of a cup 20, reaction cup
Lower end then protrude into rotation washing channel 1c in, then with washing disk 2 rotate when, lower end then equally rotation washing channel 1c do
Circular motion, on the two sides side wall of rotation washing channel 1c along its it is circumferentially staggered be distributed with magnetic sheet 1c0, magnetic sheet 1c0 has magnetic
Property, and the magnetic sheet 1c0 of two sides is spaced apart, it should be noted that the setting of magnetic sheet 1c0 should correspond to washing needle group described hereinafter
30, that is, ensure that each knit stitch position always has one piece of magnetic sheet 1c0.
One section that washing channel 1c is rotated in the present embodiment is arranged by face and is in the outer lug boss 1e and convex of arc-shaped
Platform 1f is constituted, and gap between the two then constitutes one section of rotation washing channel 1c to channel is inhaled, and the upside of the two is in smooth
Planar structure, and downside is evenly distributed with gate notch, magnetic sheet 1c0 is then staggered in the gate notch of the two, magnetic sheet 1c0
It is spaced apart and refers to that some are no magnetic sheet 1c0 in the gate notches of two sides, and the arc length between two adjacent magnetic sheet 1c0
It is the two neighboring integral multiple for setting arc length between rim of a cup 20 in top, in this way when reaction cup is rotated with washing disk 2, must can makes under it
The magnetic sheet 1c0 face that can be spaced apart with two sides is held, so as to apply magneticaction to the magnetic particle in reaction cup, makes its attachment
On the side wall of reaction cup, without being deposited on the bottom of reaction cup or being sucked away with cleaning solution.
When installation, outer lug boss 1e is arranged along the side wall of installation cavity 10, and inner convex platform 1f is along the lateral wall of installation base 11, and two
The upper end of person and the upper edge of installation base 11 are substantially flush, and the outside of installation base 11 has outwardly extending protrusion 110,
One end of inner convex platform 1f is abutted with the side of protrusion 110, is easy to implement quick location and installation, improves installation effectiveness.
With reference to Fig. 3, Fig. 4 and Fig. 6, the bottom wall of washing channel 1c is rotated in the perpendicular along washing 1 length direction of pedestal
On projection be in triangle cone structure, i.e., among it in opposite high point, both ends be in low spot, on rotation washing channel 1c
The position of both ends low spot is offered from discharge orifice 1c1, is the through-hole structure through washing 1 bottom of pedestal from discharge orifice 1c1, is washed in this way
Spillage in the process then can by from discharge orifice 1c1 flow out, and be prevent spillage pollution detection environment, therefore in the present embodiment
The gravity flow pipe fitting 1c2 adaptable with it is provided with from the lower end discharge orifice 1c1, gravity flow pipe fitting 1c2 can be used for quick with gravity line
Connection, and it is equipped with gravity flow tube fixing device 1c3 in the lower section of gravity flow pipe fitting 1c2, and gravity flow tube fixing device 1c3 is substantially l-shaped, and solid
It is scheduled on driving motor A1a, the position of gravity flow tube fixing device 1c3 lower end face gravity flow pipe fitting 1c2 offers C-shaped constraint
Hole 1c4 can carry out posture to it by constrained port 1c4 and fix, be conducive to route and neatly advise in this way after installing gravity line
Model prevents from causing to interfere to other component.
Referring to figs. 1 to Fig. 3, Figure 13 to Figure 15, washing head 3 and washing pedestal 1 in the present embodiment are two relatively independent
Component, the surface of activity setting and washing pedestal 1, and can be relatively close or far from washing pedestal 1 is main in the present embodiment
As shown, the rear side both ends of washing pedestal 1 are equipped with two lifting sliding rails 15 vertically, and to be washed by the way of sliding rail lifting
The position for washing face lifting sliding rail 15 on first 3, which has, is equipped with driving motor with its mutually matched sliding slot 37, washing pedestal 1
B1b, and driving motor B1b is lead screw motor, is removable installed on washing pedestal 1, screw rod vertically upward, and with wash
It washs first 3 rear side middle part to be threadedly coupled, in this way when driving motor B1b works, washing head 3 can be driven to slide along lifting by screw rod
15 lifting carriage of rail.
And washing head 3 is detached from when not paying attention to lifting sliding rail 15 in order to prevent, therefore a lifting sliding rail wherein
Have on 15 to the stopper section of one side bending 150, in this way when washing head 3 rises to top, then will receive stopper section 150
Stop limitation, avoids continuing to skid off, isolation 36 in place are additionally provided in the upper surface of washing head 3 at the same time, by touching in place
The heave sensor being correspondingly arranged on hair piece 36 and analyzer cooperates, and can preferably complete the control of 3 lifting distance of washing head.
The front side of washing head 3 has recessing groove 32, and recessing groove 32 is in arc-shaped, and front has opening, recessing groove 32
The center of circle and lower section washing disk 2 be coaxially disposed, inner diameter size mutually fits, and the circumferential outer rim on washing head 3 along recessing groove 32 is uniform
At least one washing needle group 30 is distributed with and at least one substrate fills needle 31, i.e., is substantially distributed in incomplete annular array,
And the center of its annular array is and sets the ring battle array center that rim of a cup 20 is distributed and be in same vertical straight line.
As shown, washing needle group 30 and substrate filling needle 31 are vertically arranged, it is circumferential along recessing groove 32 in the present embodiment
6 washing needle groups 30 are evenly distributed with, two substrates fill needle 31, and two of them substrate filling needle 31 is fixed on by mounting base
The extreme ends that recessing groove 32 indicates clockwise, the i.e. reaction cup of lower section are rotated clockwise with washing disk 2, by all washings
30 rear of needle group and substrate fill 31 face of needle, two substrates filling needle 31 in the present embodiment be respectively substrate filling needle A and
Substrate fills needle B, can fill needle 31 by two substrates and fill two different substrate solutions, each washing needle group into reaction cup
30 include an aspiration needle 300 and an injection needle 301, and the lower end of aspiration needle 300 is lower than the lower end of injection needle 301, in this way
It, can be preferably by the liquid in reaction cup by aspiration needle 300 when washing needle group 30 protrudes into the reaction cup of lower section face
Suction is walked, and injection needle 301 then avoids protruding into liquid, is conducive to the cleanliness for keeping injection needle 301, reaction cup is with washing disk
When 2 rotation, then substrate filling then can be carried out in tip position by the cleaning function of multiple washing needle groups 30.
Corresponding washing needle group 30 and substrate filling needle 31 are equipped with the pin hole 35 through its upper and lower two sides, washing on washing head 3
Aspiration needle 300 and injection needle 301 in needle group 30, which pass through after annular fixed block fixes the two, to be embedded in corresponding pin hole 35, and
It is compressed by the pressing plate 33 of top, prevents fixed block from skidding off, chase 34 is equipped in washing head 3, be mainly used for that cloth is installed
Cleaning solution injection pipeline and substrate injection pipeline are set, chase 34 has piping inlet 340, and piping inlet 340 is located at washing head
3 rear end, the side of 34 face washing head of chase, 3 upper surface is uncovered structure, and chase 34 also has at least one circle
Segmental arc 341, arc section 341 also extend through the upper surface of washing head 3, the upper surface of washing head 3 is then along the circumferential direction setting of recessing groove 32
It is fixed with metal cover board 38 by screw, the size of metal cover board 38 and the upper surface of washing head 3 are adapted, and can will remove arc section
All chases 34 except 341 cover in.
The outer rim of pressing plate 33 can cover arc section 341, but correspond to thereon arc section 341 position be equipped with pore 330,
The pipeline entered in this way from piping inlet 340, wears to arc section 341, then can be pierced by by going out pore 330 accordingly,
It is connected with the injection needle 301 or substrate of corresponding position filling needle 31, it is ensured that pipeline neatly standardizes, and the outlet tube of aspiration needle 300
It can directly be arranged from top.
With reference to Fig. 1, Fig. 6 and Figure 13, in the present embodiment, to avoid influence of the temperature to detection reagent, it is ensured that washing process
Constant temperature carries out, therefore is equipped with heating device 4 on washing pedestal 1 and washing head 3, and heating device 4 can use heat tape, electricity
Thermal resistance wire etc., as shown, the heat tape on washing head 3 directly adheres to by the heating device 4 used for heat tape
In the lower surface of washing head 3, washing head 3 is Heat Conduction Material, and chase 34 substantially in the distribution shape that wriggles, considerably increases unit tube
The time of the acceptable heating of liquid and distance in line, while to be heated evenly washing head 3, chase 34 is abided by as far as possible in setting
Symmetrically arranged mode is followed, is conducive to improve heating effect.
It washs pedestal 1 and equally uses heat-conducting, bottom is equipped with ABS thermal insulation board 16, and heat tape thereon is then set
Between the lower surface for setting in ABS thermal insulation board 16 and washing pedestal 1, in this way, can avoid heating device 4 to analyzer platform
Heat radiation influences, and is certainly the temperature on preferably control washing pedestal 1 and washing head 3, therefore the two is equipped with temperature sensor
40, contact type temperature sensor is used in the present embodiment, is separately positioned on the upper surface of washing pedestal 1 and washing head 3, thus real
Now the detection of the two temperature is fed back, is conducive to weaken ambient temperature effect.
It is the miniaturization for being further conducive to analyzer entirety, the present embodiment referring to figs. 1 to Fig. 4, Figure 10 to Figure 12
In will also mix structure and be combined with washing system, to promote blending efficiency, while saving installation space, installation also can be improved
Efficiency, as shown, the front side both ends of washing pedestal 1 are symmetrically set there are two cup holder mounting hole 17, cup holder mounting hole 17 is vertical
Setting is substantially in the hollow rod structure of upper end opening, is inside equipped with cup holder 5 in a rotatable manner, cup is compared in the upper surface of cup holder 5
The upper surface of seat mounting hole 17 is slightly higher or flush, sets glass chamber 50 with vertically arranged in cup holder 5, setting glass chamber 50 can phase
The center of rotation of cup holder 5 is arranged concentrically, also eccentric setting, mainly depending on reagent volumes in reaction cup, sets a glass chamber
50 are mainly used for placing response cup, can be put into reaction cup wherein, and realize radial positioning to it, can prevent it from rotating,
It can only move up, wash on pedestal 1 configured with the mixing motor 1d for driving cup holder 5 to rotate.
As shown, the lower end of cup holder 5 is supported on 17 bottom wall of cup holder mounting hole, the upper end by the second thrust ball bearing 53
It is equipped with thin-wall bearing 54 between the side wall of cup holder mounting hole 17, liquid or dust can be effectively prevent to invade using thin-wall bearing 54
In cup holder mounting hole 17, while certain sealing function is played, improves the heated sealed effect in cup holder mounting hole 17, it is corresponding each
Cup holder 5 is provided with a shaft 51, and shaft 51 protrudes into wherein from the underface of cup holder mounting hole 17, and by stopping head screw and cup
Seat 5 is fixedly connected, and the position that washing 1 both ends bottom wall of pedestal corresponds to shaft 51 is equipped with support 1g, the inside of two support 1g faces
Opening is equipped with baffle 1h between two support 1g, and the both ends of baffle 1h are separately fixed on two support 1g, and baffle 1h has
One horizontal mounting surface and vertical shielding surface, wherein there are gap, this implementations between horizontal mounting surface and the lower surface for washing pedestal 1
Each cup holder 5 is corresponded in example and is equipped with mixing motor 1d, as shown, the vertical fixed peace of setting upward of two mixing motor 1d
Mounted in the middle part of the horizontal mounting surface of baffle 1h, motor shaft vertical be located at upward horizontal mounting surface and wash pedestal lower surface it
Between, it is arranged with belt wheel thereon, and the position that support 1g opening is corresponded in same shaft 51 is also arranged with belt wheel, in two belt wheels
On be arranged with synchronous belt 1d0, then mix motor 1d by synchronous belt 1d0 drive shaft 51 rotate, thus drive cup holder 5 rotate,
Realize that reagent mixes, the vertical shielding surface of baffle 1h extends from the bending of the front side of horizontal mounting surface is vertical downwards, plays certain
Occlusion effect.
Rotation shape with reference to Fig. 1, Fig. 3 and Figure 12, in the present embodiment preferably to monitor control washing disk 2 and cup holder 5
State, therefore corresponding driving motor A1a and mixing motor 1d are equipped with detection device 6, and driving motor A1a and mixing motor 1d are
Variable speed electric motors, particularly, and mix motor 1d while still reversible electric machine, i.e. its revolving speed and steering is adjustable, the main packet of detection device 6
Optical code disk 60 and photoelectric sensor 61 are included, optical code disk 60 is sleeved on the motor shaft lower end of corresponding motor, and photoelectric sensor 61 is solid
It is scheduled on corresponding position, positioned at the outside of optical code disk 60, the monitoring of motor rotary state is realized in the two cooperation, and is fed back into processing
The heart, then issue corresponding suitable instruction.
Referring to figs. 1 to Figure 15, the course of work of the disc type chemical illumination immunity analysis instrument washing system of the application is as follows,
It completes the filling such as sample, reagent and magnetic particle solution and the reaction cup 7 by dilution process is put on washing pedestal 1 by handgrip
One cup holder 5 on the right is set in glass chamber 50, carries out mixing operation for the first time to it, washs adding for 1 bottom of pedestal at the same time
Thermal 4 works always, is acted on by heat radiation, it is ensured that blending process is constantly in isoperibol.
It completes to mix for the first time and then be sent into be incubated in storehouse by the 7 of mixing by handgrip to be incubated for, complete after being incubated for
Reaction cup setting in rim of a cup 20 on washing disk 2 is put by handgrip, then gone up and down again by the washing needle group 30 on washing head 3
The washing and suction to reagent solution in reaction cup 7 are completed, and same reaction cup 7 can be by the flushing of multiple washing needle groups 30
Cleaning function, and the suction-operated because washing Shi Junyou magnetic sheet 1c0, can substantially reduce the Loss Rate of magnetic particle, and improve and wash
It washs effect and squeezes into substrate in end position after washing is completed, washing 1 left end cup holder 5 of pedestal is then sent by handgrip again
It sets in glass chamber 50, carries out second and mix, shorten moving distance, be conducive to improve detection efficiency.
In addition, make washing and blending process substantially all in the environment of opposite constant temperature because of the presence of heating device 4,
Ambient temperature effect is weakened, can further improve the accuracy of late detection.
Finally, it should be noted that foregoing description is only the preferred embodiment of the present invention, the ordinary skill people of this field
Member under the inspiration of the present invention, without prejudice to the purpose of the present invention and the claims, can make multiple similar tables
Show, such transformation is fallen within the scope of protection of the present invention.
Claims (10)
1. a kind of disc type chemical illumination immunity analysis instrument washing system characterized by comprising
It washs pedestal (1)；
It washs disk (2), is set in washing pedestal (1) in a rotatable manner, circular array, which is distributed with, on the washing disk (2) sets
Rim of a cup (20), described to set rim of a cup (20) vertically arranged；
Driving motor A (1a) is used to that the washing disk (2) to be driven to rotate；
Washing head (3) is movably set in above washing pedestal (1), and can be relatively close or far from the washing pedestal (1),
At least one washing needle group (30) and at least one substrate filling needle (31) are vertically equipped on washing head (3)；
Driving motor B (1b) is used to drive the washing head (3) close to or far from washing pedestal (1).
2. disc type chemical illumination immunity analysis instrument washing system according to claim 1, it is characterised in that: the washing
The position of corresponding washing disk (2) has the installation cavity (10) of upper end opening, the washing disk (2) and the installation cavity on pedestal (1)
(10) upper end size is adapted, and has the installation base (11) of structure in a ring, the installation base in the installation cavity (10)
(11) middle part has the mounting hole (12) of setting concentric with it, and the driving motor A (1a) is located at immediately below installation base (11),
And vertically upward, motor shaft protrudes into mounting hole (12) is connected with the washing disk (2) of top.
3. disc type chemical illumination immunity analysis instrument washing system according to claim 2, it is characterised in that: the driving
Motor A (1a) is connected by intermediate attachment base (13) with installation base (11), the upper end of driving motor A (1a) and intermediate attachment base
(13) it is detachably connected that screw is all made of between, and between intermediate attachment base (13) and installation base (11)；
The motor shaft of the driving motor A (1a) is connected by middle support base (14) with washing disk (2), the middle support base
(14) it is located in mounting hole (12), and is solidly set on the motor shaft by stopping head screw, on the inside of the intermediate attachment base (13)
With annular heavy platform, middle support base (14) structure in T shape, middle support base (14) lower end and the annular heavy platform side
The first thrust ball bearing (1a0) is embedded between wall.
4. disc type chemical illumination immunity analysis instrument washing system according to claim 2, it is characterised in that: the installation
Rotation washing channel (1c) annular in shape is formed between boss (11) outer wall and installation cavity (10) inner wall, the rotation washing is logical
Road (1c) and top set that rim of a cup (20) position is corresponding, and circumferentially interlock on the two sides side wall of rotation washing channel (1c)
Magnetic sheet (1c0) is distributed with.
5. disc type chemical illumination immunity analysis instrument washing system according to claim 4, it is characterised in that: the rotation
The bottom wall lowest part of washing channel (1c) be equipped with through washing pedestal (1) lower surface from discharge orifice (1c1), and configured with it is described
The gravity flow pipe fitting (1c2) adaptable from discharge orifice (1c1).
6. disc type chemical illumination immunity analysis instrument washing system as claimed in any of claims 1 to 5, feature
It is: is equipped at least one lifting sliding rail (15) on the washing pedestal (1) vertically, the washing head (3) and the lifting is slided
Rail (15) is slidably matched, the driving motor B (1b) be lead screw motor, and be mounted on washing pedestal (1) on, screw rod with it is described
Washing head (3) is threadedly engaged.
7. disc type chemical illumination immunity analysis instrument washing system according to claim 6, it is characterised in that: the washing
The position of face washing disk (2) has the recessing groove (32) in arc-shaped on head (3), and the front side of the recessing groove (32) is open, institute
The outer rim that washing needle group (30) and substrate filling needle (31) are stated along recessing groove (32) is distributed, and is compressed by pressing plate (33).
8. disc type chemical illumination immunity analysis instrument washing system as claimed in any of claims 1 to 5, feature
Be: the bottom of washing pedestal (1) has ABS thermal insulation board (16), the ABS thermal insulation board (16) and washing pedestal (1)
Between the lower surface and lower surface of washing head (3) is equipped with heating device (4), and washs pedestal (1) and washing head (3)
Top is equipped with temperature sensor (40).
9. disc type chemical illumination immunity analysis instrument washing system according to claim 8, it is characterised in that: the heating
Device (4) is heat tape, wriggles and is distributed with chase (34) in the washing head (3), the chase (34) is through washing
The upper surface of head (3), the upper surface of the washing head (3) is covered with metal cover board (38).
10. disc type chemical illumination immunity analysis instrument washing system according to claim 1, it is characterised in that: described to wash
The front side for washing pedestal (1) is equipped at least one cup holder mounting hole (17), pacifies in a rotatable manner in the cup holder mounting hole (17)
It equipped with cup holder (5), sets a glass chamber (50) in the cup holder (5) with vertically arranged and open upper end, is configured in washing pedestal (1)
There is the mixing motor (1d) to drive the cup holder (5) to rotate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910127358.3A CN109675890B (en) | 2019-02-20 | 2019-02-20 | Disk type chemiluminescent immunoassay analyzer washing system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910127358.3A CN109675890B (en) | 2019-02-20 | 2019-02-20 | Disk type chemiluminescent immunoassay analyzer washing system |
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| CN109675890B CN109675890B (en) | 2024-04-02 |
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| CN110514824A (en) * | 2019-09-24 | 2019-11-29 | 重庆科斯迈生物科技有限公司 | Washing system of suction type chemiluminescence immunoassay analyzer |
| CN112858664A (en) * | 2021-01-14 | 2021-05-28 | 烟台信达威医疗科技有限公司 | Cleaning device of chemiluminescence immunoassay analyzer |
| CN114833141A (en) * | 2022-04-28 | 2022-08-02 | 科来思(深圳)科技有限公司 | Washing module of full-automatic chemiluminescence immunoassay analyzer |
| CN116087484A (en) * | 2022-11-11 | 2023-05-09 | 重庆智迈医疗科技有限公司 | Compact high-efficiency magnetic particle immunity analyzer |
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