CN102565439A - Incubation part device for full-automatic chemiluminescence immunity analyzer and control method for incubation part device - Google Patents
Incubation part device for full-automatic chemiluminescence immunity analyzer and control method for incubation part device Download PDFInfo
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- CN102565439A CN102565439A CN2011104523353A CN201110452335A CN102565439A CN 102565439 A CN102565439 A CN 102565439A CN 2011104523353 A CN2011104523353 A CN 2011104523353A CN 201110452335 A CN201110452335 A CN 201110452335A CN 102565439 A CN102565439 A CN 102565439A
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Abstract
The invention relates to an incubation part device for a full-automatic chemiluminescence immunity analyzer and a control method for the incubation part device and belongs to the technical field of in-vitro detection of medical equipment. The incubation part device comprises an upper disc, a lower disc, a spindle, a main body and a shell, wherein the upper disc is a cup carrying disc, is fixed at the upper end of the spindle and can rotate around the spindle; the lower disc is a positioning disc, when the positioning disc is fixedly connected with the cup carrying disc, the positioning disc is separated from the main body and can rotate along with the cup carrying disc, and when the positioning disc is fixedly connected with the main body, the positioning disc is connected with the cup carrying disc through a bearing and does not rotate along with the cup carrying disc; the lower end of the spindle is connected with the main body through the bearing; and the shell is used for loading the main body and is fixed with a frame of the full-automatic chemiluminescence immunity analyzer. The invention has the advantages that: the device has a simple structure and is easy to implement, and the detection speed is easily improved continuously.
Description
Technical field
The invention belongs to medicine equipment vitro detection technical field, what relate to a kind of full-automatic chemical luminescence immunoassay appearance hatches part device and control method thereof.
Background technology
For understanding the patient health situation, can check patient's body fluid sample, for example, blood, urine, ascites pleural fluid or cerebrospinal fluid.Through check, can confirm the composition of patient's body fluid sample, thereby obtain patient's health information patient's body fluid sample.
Full-automatic chemical luminescence immunoassay appearance is a kind of instrument that can carry out the immunology quantitative test to patient's body fluid sample, can check disease syndromes such as anaemia, angiocardiopathy, congenital disorders, sex hormone, infectious disease, metabolic function, tumor markers, medicine monitoring and thyroid gland.The application of full-automatic chemical luminescence immunoassay appearance; Make checkout procedure realize robotization fully, improved the work efficiency of immunoassay, eliminated artificial subjective error; Stablized the quality of immunity inspection, for clinical immunoassay provides a reliably approach efficiently.
Full-automatic chemical luminescence immunoassay appearance mainly by sample reagent application of sample portion, loading part, hatch portion, photometer, liquid-way system and software control system and form.Sample reagent application of sample portion can accomplish the task of being filled into sample and reagent reaction cup automatically according to system directive; Loading part is used to realize depositing and transmitting function of sample suction head, sample, reagent and reaction cup; The portion of hatching is used for reaching wherein in the pattern detection process to reaction cup, and reactant liquor automatically performs various operation stepss; Photometer can detection reaction liquid luminous signal; Liquid-way system can be realized the detection of pump, valve, pipeline, syringe pump mechanism and liquid road detection module to total system and use control that software control system is used for control is coordinated in the action that system's various piece is accomplished.
The Interventions Requested that carry out immunoassay are tens kinds even hundreds of nearly, has the immunoassay that many samples will carry out a plurality of Interventions Requested simultaneously.In full-automatic chemical luminescence immunoassay appearance, rationally also control the detection that a plurality of samples carry out a plurality of Interventions Requested appropriate to the occasionly, be one of key that realizes the checkout procedure robotization.
The step of the checkout procedure of full-automatic chemical luminescence immunoassay appearance comprises: add sample, add reagent, incubation reaction, cleaning are separated, filling preexciting liquid, load reaction cup, filling exciting liquid, luminous signal detects and testing result calculating etc.Hatching part device and control method thereof is a kind of solution that realizes the robotization testing process of multisample multiple testing project.
Summary of the invention
Immunoassay relied on manual and semi-automatic equipment to realize in the past; The present invention provides a kind of device and control method thereof of confirming the sample composition automatically for realizing the immunoassay full automation, is used to solve the control problem that multisample carries out the testing process robotization of multiple testing project.
The technical scheme that the present invention takes is: comprise two disks, a main shaft, a main body and a shell up and down, last disk is to carry the cup dish, is fixed on the main shaft upper end; Can rotate around main shaft, lower disc is a positioning disk, when being fixed together with a year cup dish; Positioning disk breaks away from main body, can follow to carry the rotation of cup dish, when being fixedly connected with main body; Positioning disk is connected with a year glass dish through bearing, does not follow a year cup and coils rotation, and the main shaft lower end is connected with main body through bearing; Shell is used to load main body, and is fixed together with the support body of full-automatic chemical luminescence immunoassay appearance.
The present invention is carried the cup dish and is comprised reaction cup dish and rotating disk, and the reaction cup dish is used to load reaction cup, and rotating disk is used for fixing several reaction cup dishes.
Positioning disk of the present invention comprises annulus, detent mechanism and magnetic stripe, is fixed with detent mechanism and magnetic stripe on the annulus, and detent mechanism is used for confirming the initial position of positioning disk, and makes positioning disk and main body fix or break away from, and magnetic stripe is used for the sample composition is washed separation.
Main body of the present invention comprises main cavity, pull bar, gear and drive motor, and pull bar is used to cooperate detent mechanism realization positioning disk to follow year cup dish rotation or keeps motionless, and gear and drive motor are used for driving year cup dish rotation.
A kind of full-automatic chemical luminescence immunoassay appearance hatch the part device control method; Comprise to its year cup dish and positioning disk rotation carry out two kinds of controls; A kind of is to carry the cup dish with respect to the each position of rotating a reaction cup of positioning disk by set time beat control; Another kind is that the control positioning disk is followed a year cup dish rotation together, controls by the set time beat and carries the position that cup coils a reaction cup of the each rotation of relative positioning dish, and utilize this mode to control the test item that arrives the magnetic wash separated region and accomplish incubation reaction just; And begin to carry out the reaction cup absolute position of incubation reaction; Be certain fixed position of calculating, in the magnetic wash separated region, the reaction cup on the cleaning positions carried out the magnetic wash lock out operation by the Interventions Requested requirement according to the incubation reaction time of Interventions Requested.
The present invention utilizes positioning disk to follow to carry the control mode that the cup dish rotates together, and the test item that carries out the sample check is carried out sample filling, reagent filling and loaded the operation of new reaction cup to position, reaction cup hole.
Bottom does further analysis to the present invention:
(1) hatch part device by last disk, as carry the cup dish, lower disc is formed as positioning disk, main shaft, main body and shell.Carry the cup dish and be used to load a plurality of, like 80 reaction cup, and according to the set time beat, as 20 seconds, the relative positioning dish rotated, and rotates a reaction cup position at every turn; Positioning disk is connected to through sliding bearing and carries on the cup dish; When the detent mechanism of positioning disk is set to a kind of state; Positioning disk is fixedly connected on and carries on the cup dish; Follow and carry the cup dish and rotate together, this situation is used to realize the executable operations step: add sample, add reagent and load the function of the operation of new reaction cup; When the detent mechanism of positioning disk is set to another kind of state; Positioning disk has only bearing to be connected with a year cup dish, and is fixedly connected with the portion main body of hatching, and coils and can rotate by the relative positioning dish so carry cup; This situation is used to realize carrying the function that the cup dish rotates according to set time beat relative positioning dish; In addition, the positioning disk outside is equipped with magnetic stripe, is used to realize the magnetic wash separation; Main shaft is used for linking together with main body carrying the cup dish; Housing is used to load main body.
(2) for realizing incubation reaction, have on the main body one can place a plurality of (as, 80) annular cavity type of reaction cup.The reaction cup absolute position is with respect to the changeless position of housing.For guaranteeing the incubation reaction time; The reaction cup absolute position that the incubation reaction of all Interventions Requested finishes is same position; The reaction cup absolute position that incubation reaction begins is then according to different Interventions Requested and difference, and the reaction cup absolute position that the incubation reaction that various Interventions Requested are corresponding begins can be confirmed according to the incubation time of Interventions Requested.
(3) for realizing that magnetic wash separates, magnetic stripe is installed on the positioning disk, the reaction cup position that incubation reaction finishes is that magnetic stripe begins the place, and magnetic stripe end is that reaction cup is left and hatched part device and get into photometric reaction cup position.The positioning disk zone that correspondence is equipped with magnetic stripe is the magnetic wash separated region.
The control method of (4) hatching part device is used to realize the control to wherein the rotation of carrying cup dish and positioning disk.Hatch and comprise two kinds of rotations in the ring.A kind of is a rotation of carrying cup dish relative positioning dish, when occurring in set time beat expiration, once rotates a reaction cup position, and purpose is to guarantee just to accomplish when reaction cup turns to the magnetic wash separated region incubation reaction; Another kind is that year cup dish and positioning disk lock together the rotation of carrying out; Occur within the set time beat; Once turned reaction cup positional number is confirmed that by the operation of carrying out purpose is to cooperate to accomplish specific operation, for example; The respective reaction cup turns to fixing sample filling position filling sample when adding sample, the respective reaction cup turns to fixing reagent filling position filling reagent etc. when adding reagent, and the respective reaction cup must rotate back into the origin-location after these operations were accomplished.
(5) portion of the hatching control method of the many test items of generation will meet four conditions.The one, confirm that test item gets into the condition of the order of hatching part device, promptly add earlier according to emergency treatment test sample item, add behind the common test sample item; Next is that the long test sample item of incubation time adds earlier, adds behind the test sample item of incubation time weak point; Being the test item sequence number at last adds earlier at preceding test item, the test item sequence number after test item after add.The 2nd, to the restrictive condition of various operation amounts in the set time beat; Promptly in each set time beat, carry out maximum 1 time sample operations; No more than 2 times reagent operation, operation of 1 time reaction cup load operation, and corresponding cleaning at the most and preexciting liquid performance.The 3rd, what each test item all will meet its corresponding single Interventions Requested hatches the part device control method.The 4th, various running time sums can not be greater than the cycle length of beat in each beat.
Hatching part device is that full-automatic chemical luminescence immunoassay appearance is realized one of important device of checkout procedure automatically; The immune incubation reaction of carrying out automatically in the full-automatic chemical luminescence immunoassay appearance, magnetic wash are separated and the pipeline system test of multisample multiple testing project, all by hatching part device and control method realizes.
With manual and semi-automatic immunoassay apparatus in comparison, the invention provides the full automatic method of a kind of realization immunoassay.In addition, apparatus structure according to the invention is simple, is convenient to realize, also is easy to improve constantly simultaneously detection speed.
Description of drawings
Fig. 1 is that part device assembly figure is hatched in the present invention, and the sectional view of slice location is as shown in Figure 5;
Fig. 2 is that the part device exploded view is hatched in the present invention;
Fig. 3 is reaction cup of the present invention fixed position numbering figure;
Fig. 4 is the structural drawing of positioning disk of the present invention;
Fig. 5 is the function implementation structure synoptic diagram of the detent mechanism of positioning disk of the present invention, is the sectional view of Fig. 1 slice location;
Fig. 6 is that the cup dish is carried in the present invention and positioning disk passes through three interconnective structural drawing of sliding bearing.
Embodiment
At first sketching full-automatic chemical luminescence immunoassay appearance forms and the various piece function:
Full-automatic chemical luminescence immunoassay appearance by disposable suction head loading part, reaction cup loading part, sample loading part, reagent loading part, sample reagent application of sample portion, hatch portion, photometer, liquid-way system, software control system and instrument support body and form.
The suction head loading part is used to deposit the sample suction head, can the disposable suction head that prevent sample cross contamination be provided for sample reagent application of sample portion.
The reaction cup loading part is used to deposit disposable reaction cup, can transmit reaction cup, ajust and be cached to reaction cup buffer memory mechanism, according to test request reaction cup is sent into from reaction cup buffer memory mechanism and is hatched ring.
The sample loading part is used to deposit sample rack and sample tube, can check whether sample rack exists, and the scanned samples test tube bar code is for test provides sample.
Whether the main and auxiliary reagent that helps is deposited and refrigerated to the reagent loading part, detect the main and auxiliary kit that helps and exist, and rocks mixing reagent, and scanning reagent bar code is for test provides main and auxiliary reagent.
Sample reagent application of sample portion can realize picking up suction head from the suction head loading part, moves to the sample cabin then and draws sample, again the sample of drawing is filled into the portion of hatching and carries in the reaction cup of cup dish, delivers to the suction head that has used the function of solid waste case at last; Also can realize drawing reagent, again reagent is filled into the portion of hatching and carry in the reaction cup of cup dish, arrive the function of reagent probe cleaning position cleaning reagent probe then from the reagent cabin.
The portion of hatching is sent to reaction cup the application of sample position of hatching ring, adds reagent position, cleaning station and photometer elevating mechanism take-off location by the set time beat by gearing.Utilize thermostat to keep hatching constant temperature in the ring, so that carry out incubation reaction; Through permanent magnetic device the reactant liquor of accomplishing incubation reaction is implemented magnetic resolution; Use cleaning fluid to add sample and reagent in the ring and accomplished incubation reaction, inhale through aspirating needle and remove waste liquid with the reaction cup of magnetic resolution is washed to hatching, and the preexciting liquid of annotating of the reaction cup after washing.
The photometer elevating mechanism is sent in the photometer hatching the reaction cup that adds preexciting liquid in the device; Carry out luminescence-producing reaction to reaction cup filling exciting liquid; Photomultiplier reads luminous signal and sends a signal to master control board and handles; Inhale then and remove waste liquid, will move to the solid collection box with the reaction cup of crossing.
Filling and waste liquid that liquid-way system utilizes the liquid road to carry out clean and maintenance, preexciting liquid and the exciting liquid on reagent filling, reagent probe cleaning, reaction cup flushing, liquid road reclaim.Comprise using and controlling to pump, valve, pipeline, syringe pump mechanism and liquid road detection module.
Software control system is used for receiving and processing photometer test signal, calculating detect data, output sample composition result.Control instrument associated mechanisms and liquid-way system operation simultaneously.
Embodiment 1: full-automatic chemical luminescence immunoassay appearance hatch part device
Comprise two disks, a main shaft, a main body and a shell up and down, last disk is to carry the cup dish, is fixed on the main shaft upper end; Can rotate around main shaft, lower disc is a positioning disk, when being fixed together with a year cup dish; Positioning disk breaks away from main body, can follow to carry the rotation of cup dish, when being fixedly connected with main body; Positioning disk is connected with a year glass dish through bearing, does not follow a year cup and coils rotation, and the main shaft lower end is connected with main body through bearing; Shell is used to load main body, and is fixed together with the support body of full-automatic chemical luminescence immunoassay appearance.
The present invention is carried the cup dish and is comprised reaction cup dish and rotating disk, and the reaction cup dish is used to load reaction cup, and rotating disk is used for fixing several reaction cup dishes.
Positioning disk of the present invention comprises annulus, detent mechanism and magnetic stripe, is fixed with detent mechanism and magnetic stripe on the annulus, and detent mechanism is used for confirming the initial position of positioning disk, and makes positioning disk and main body fix or break away from, and magnetic stripe is used for the sample composition is washed separation.
Main body of the present invention comprises main cavity, pull bar, gear and drive motor, and pull bar is used to cooperate detent mechanism realization positioning disk to follow year cup dish rotation or keeps motionless, and gear and drive motor are used for driving year cup dish rotation.
Further specify the structure that part device is hatched in the present invention below in conjunction with accompanying drawing.
Fig. 1 is hatched part device assembly figure.For realizing confirming the robotization of sample composition; Also need other not display device fit into performing check; For example; Need the sample application arm to cooperate the filling of accomplishing sample in annotate the specially position (No. 70 positions among Fig. 3) of sample of the portion of hatching; Need the reagent sample arm to cooperate the filling of accomplishing reagent in annotate the specially position (No. 60 positions among Fig. 3) of reagent of the portion of hatching; Cleaning separate areas (No. 4 to No. 14 bands of position among Fig. 3) in the portion of hatching needs cleaning station cooperate to accomplish the filling cleaning fluid and extracts waste liquid, and the position (No. 49 positions among Fig. 3) that loads reaction cup specially in the portion of hatching needs the reaction cup load maintainer to cooperate to accomplish reaction cup to be loaded into to hatch in portion's reaction cup putting hole.But, confirm that the robotization testing process of sample composition, key are to hatch part device and how turn to wherein reaction cup on the position that these operations take place automatically.
Shown in Figure 2 for hatching the exploded view of part device.Hatch part device above be to carry cup dish 3, it is fixed on the fixed head 14 at main shaft 5 tops.Positioning disk 4 is connected with a year cup dish 3 through three sliding bearings 11 (referring to Fig. 6), and a year cup coils 3 and can rotate with respect to positioning disk 4.Main shaft 5 bottoms are connected with the center pit of hatching part device main body 6 15 through two main shaft bearings 13.Hatch part device main body 6 and hatch portion's shell 7 and link together through three screws.Drive motor 1 is fixed in hatches on the part device main body 6, and the driving shaft of drive motor 1 upper end is fixed with gear 2, and gear 2 is meshing with each other with the tooth that carries cup dish 3 outsides.Drive motor 1 can drive through gear 2 and carry 3 rotations of cup dish.Detent mechanism 8 on the positioning disk 4 can make a year cup coil 3 relative positioning dishes 4 and rotate, or also can make positioning disk 4 follow year glass dish 3 rotation together as required.
Shown in Figure 3 for carrying numbering synoptic diagram in reaction cup absolute position on the cup dish 3.Carry 21,80 pin holes 20 in position, hole that 80 placing response cups are arranged on the cup dish 3.When a year cup dish 3 was in initial position, the fixed number of the position, hole 21 of its 80 placing response cups (fixed number of housing 7 relatively) was 0 to 79.Wherein, 2,4,5,9,10, No. 11 positions are that reaction cup is cleaned the fixed position, and No. 3 positions are fixed positions that preexciting liquid adds, and No. 60 positions are fixed positions of filling reagent; No. 70 positions are fixed positions of filling sample; No. 49 positions are the fixed positions that load the new reaction cup, and the magnetic stripe position on the corresponding positioning disk in position, No. 4 positions to 14 is the zone that reactant liquor carries out magnetic resolution in the reaction cup.If current need the operation (as; Add sample, add reagent and load reaction cup) reaction cup not at the respective anchor site place; Must positioning disk 4 follow and carry cup dish 3 and rotate together and make this reaction cup, accomplish behind the corresponding operating positioning disk 4 and follow and carry cup dish 3 and return back to the origin-location more together to place, corresponding fixed position.Different therewith is always when the beat reaction cup turns to corresponding fixed position by the set time, to carry out the operation of separation of reaction cup magnetic wash and filling preexciting liquid.
Fig. 4 is the structural drawing of positioning disk 4.Positioning disk 4 inboards are fixed with detent mechanism 8, and the outside is fixed with magnetic stripe 9.When the reaction cup on carrying cup dish 3 turned to this zone, the reactant liquor in the reaction cup carries out magnetic wash to be separated.Be that composition to be measured is adsorbed on the reaction cup sidewall, simultaneously, the cleaning fluid of in reaction cup, annotating is drained the liquid in the reaction cup again, so have only composition to be measured to be retained on the reaction cup sidewall.So just realized the purpose that composition to be measured separates with other reactant liquor.
Fig. 5 is carrying that a cup dish relative positioning dish rotates or positioning disk is followed a structural representation that carries detent mechanism 8 correlated parts action situation under the situation that the cup dish rotates.
When requiring to carry the position of a reaction cup of cup dish 3 relative positioning dishes, 4 rotations; Electric control system control motor moves down through gear driven tooth bar 23; One end and tooth bar 23 fixing pull bars 16 are spurred downwards; Because of the lower end of detent mechanism pin 10 is embedded in the pull bar groove 24 of pull bar 16, so detent mechanism pin 10 is pulled out downwards from the pin hole 20 that carries cup dish 3.At this moment, positioning disk zero-position stopping piece 12 also moves down and gets in the positioning disk zero-position stopping piece optocoupler 18, and positioning disk zero-position stopping piece optocoupler 18 detects detent mechanism pin 10 the next signal (carrying cup dish and positioning disk unlocking signal), sends to electric control system.Electric control system controlling and driving motor 1 again rotates, and rotates a reaction cup position (referring to Fig. 2) through gear 2 a drives year cup dish 3.Electric control system control motor moves up through gear driven tooth bar 23; Drive pull bar 16 upwards; Detent mechanism pin 10 is moved up, enter into the pin hole 20 that just rotates, move disengaging positioning disk zero-position stopping piece optocoupler 18 simultaneously on the positioning disk zero-position stopping piece 12; Positioning disk zero-position stopping piece optocoupler 18 detects detent mechanism pin 10 upper signal (carrying cup dish and positioning disk locking signal), sends to electric control system.
When requiring positioning disk 4 to follow to carry cup dish 3 to rotate together; Electric control system will detect detent mechanism pin 10 earlier upper signal (carrying cup dish and positioning disk locking signal); And then controlling and driving motor 1 rotates, and drives through gear 2 and to carry cup dish 3 and turn to the fixed position that will carry out certain operation.Behind the complete corresponding operating, positioning disk 4 is followed a year cup dish 3 and is rotated back into original position again.Coming and going the location of rotating relies on the photoelectric encoder step-by-step counting of drive motor 1 to realize.
Comprise to its year cup dish and positioning disk rotation carry out two kinds of controls; A kind of is to carry the cup dish with respect to the each position of rotating a reaction cup of positioning disk by set time beat control; Another kind is that the control positioning disk is followed a year cup dish rotation together; Carry the each position of rotating a reaction cup of cup dish relative positioning dish by set time beat control; And utilize this mode to control the test item that arrives the magnetic wash separated region and accomplish incubation reaction just, and begin to carry out the reaction cup absolute position of incubation reaction, be certain fixed position of calculating according to the incubation reaction time of Interventions Requested; In the magnetic wash separated region, the reaction cup on the cleaning positions is carried out the magnetic wash lock out operation by the Interventions Requested requirement.
The present invention utilizes positioning disk to follow to carry the control mode that the cup dish rotates together, and the test item that carries out the sample check is carried out sample filling, reagent filling and loaded the operation of new reaction cup to position, reaction cup hole.
Further specify the control method of hatching part device through concrete experimental example below.
Through to hatching the control of part device, can realize the Automated inspection process of multisample multiple testing project, the operation steps that checkout procedure specifically comprises has the sample of adding, adds reagent, incubation reaction, magnetic wash is separated and load the new reaction cup.
Hatch each operation steps of checkout procedure in the part device for completion, hatch part device and comprise two kinds of rotations.A kind of is by the set time beat (for example; 20 seconds) carry the cup dish with respect to the each position of rotating a reaction cup of positioning disk; Accomplish incubation reaction when its effect is control test event arrival magnetic wash separated region, and in the magnetic wash separated region, test item is carried out the cleaning lock out operation.Another kind is that positioning disk is followed and carried the cup dish and rotate together, and its effect is that the control detection project is accomplished sample filling, reagent filling and loaded the operation of new reaction cup.
Add the calculating of reagent and the fixed position number that adds sample.Position Number with reference to figure 3.The corresponding fixed position of this reaction cup number when calculating application of sample according to the incubation time of test item.If the set time beat is 20 seconds, the position that any Interventions Requested incubation reaction finishes all is No. 15 positions, and this also is that reaction cup is rotated counterclockwise first position that gets into magnet ring.The fixed position number of filling reagent equals the incubation reaction time (is unit with the second) divided by 20 seconds, to add 15 afterwards.For example, the total incubation time of T3 is 14.7 minutes, and the fixed position of its test item filling reagent number is 14.7 * 60 ÷ 20+15 ≈ 59.For the test duration is shortened as far as possible, sample and filling reagent is at same position if the running time allows to annotate, or in the previous position of filling reagent.For example, the fixed position of T3 filling sample number is 59 or 60.Listed adding sample, adding fixed position that reagent separates with magnetic wash number of partial test project in the table 1.
The filling sample of table 1 partial test project, the filling reagent fixed position of separating number with magnetic wash
What table 2 and table 3 had provided that the partial test project confirms the sample composition hatches the part device control method, comprises the corresponding fixed position of time beat (for example 20 seconds) sequence number, operation and executable operations after beginning to test number.If the incubation reaction asynchronism(-nization) of Interventions Requested, then the part device control method of hatching of Interventions Requested also can be different.
The part device control method of hatching of single test item is given an example.
With reference to figure 3.With T3 be these Interventions Requested of example explanation hatch the part device control method.When carrying out T3 test item when detecting, this test item meets hatches the part device control method shown in the table 2.At first, load 80 new reaction cups to carrying cup dish 3.If No. 60 the corresponding reaction cup of carrying on the cup dish in position is empty; Then to reaction cup filling sample, promptly positioning disk is followed and is carried the rotation together of cup dish, clockwise rotates the reaction cup of No. 60 positions to No. 70 positions; The sample application arm adds sample, and positioning disk is followed a year cup dish again and returned back to the position together No. 60.When 20 of beat seconds expire at that time, carry a cup dish relative positioning dish and rotate counterclockwise a reaction cup position, this reaction cup arrives No. 59 positions.To the reaction cup reagent of annotating, promptly positioning disk is followed and is carried the cup dish and rotate together, clockwise rotates the reaction cup of No. 59 positions to No. 60 positions No. 59 positions, and the reagent sample arm adds reagent, and positioning disk is followed and carried the cup dish and return back to the position together No. 59.When expirations in 20 seconds of the set time beat, to carry a cup dish relative positioning dish and rotate counterclockwise a reaction cup position, this reaction cup arrives No. 58 positions.When the expiration in 20 seconds of time beat, carry the cup dish and rotate counterclockwise a reaction cup position later on regard to the relative positioning dish.When this reaction cup arrives No. 15 positions, accomplished incubation reaction.Position, No. 14 positions to 4 has magnetic, be used for composition to be tested is adsorbed onto the reaction cup sidewall so that when flushing composition to be measured be retained in the reaction cup.When this reaction cup is followed when carrying the cup dish and turning to No. 11 positions exhaustion liquid in containers, filling cleaning fluid.When this reaction cup turns to the position No. 4, wherein liquid exhausts.After the next time beat, promptly this reaction cup arrives No. 3 positions, to the preexciting liquid of wherein annotating.When arriving No. 0 position, this reaction cup is fed in the photometer, and to the exciting liquid of wherein annotating, produces light signal, and the electric unit measuring-signal is also exported result data.Because the reaction cup of No. 0 position is sent in the photometer; After carrying the cup dish and rotating a time beat again; This is vacated position (i.e. No. 79 positions) and is placed into the new reaction cup; Be that positioning disk is followed a year cup dish rotation together, clockwise rotate No. 79 positions to No. 49 positions and load the new reaction cups, return back to the position more together No. 79.
Table 2 T3 and T4's hatches the part device control method
Table 3 FT3 and TSH-3's hatches the part device control method
The part device control method of hatching of many test items is given an example.
Putting into a plurality of test items when carrying the cup dish and testing, is to realize Automated inspection, meet following four conditions:
The one, meet the condition of test item addition sequence.Emergency treatment test sample item adds earlier, adds behind the common test sample item; Next is that the long test sample item of incubation time adds earlier, adds behind the test sample item of incubation time weak point; Be that sequence number adds earlier at preceding test item in the test item database at last, sequence number after test item after add.
The 2nd, meet condition to operation that test item applies.Sample operations, TS consuming time can only be arranged at most 1 time in each set time beat; Reagent is operated no more than 2 times in each time beat, each TR consuming time; The preexciting liquid of 2,3,4,5,9,10, No. 11 positions adding operation or cleaning operation can carry out TD always consuming time as required simultaneously in each time beat; The operation of 1 loading reaction cup can only be arranged in each time beat, and consuming time is TC; Carrying cup dish and positioning disk required time of rotation in each time beat is TM; The test item quantity of carrying out incubation reaction is unrestricted.
The 3rd, what each test item all will meet its corresponding single Interventions Requested hatches the part device control method, and what promptly be similar to the so single Interventions Requested of table 2 and table 3 hatches the part device control method.
The 4th, the TS+TR+TD+TC+TM of each beat of requirement or 2TR+TD+TC+TM should be not more than the cycle length of beat.
Hatch the part device control method for the ease of explanation to what a plurality of test items were tested, be described below for example:
Supposing to have 3 serum samples, is respectively sample 1, sample 2 and emergency treatment sample 3.Sample 1 detects T3 and TSH-3 project, and sample 2 detects T4 and TSH-3 project, and emergency treatment sample 3 detects T4 and FT3 project.Can obtain 6 test items in view of the above, as shown in table 4.
Table 4 is according to 6 test items of test item sequence number tabulation
| The test item sequence number | The test item content | The test item sequence number | The test item |
| Test item | |||
| 1 | The T3 of |
|
The TSH-3 of |
| |
The TSH-3 of |
|
The T4 of |
| |
The T4 of |
|
The FT3 of |
At first, confirm that 6 test items add the order of carrying the cup dish.According to above-mentioned condition one, can obtain arranging situation as shown in table 5.
Table 5 is according to 6 test items that add the sequential list that carries the cup dish
| Addition sequence | The test item sequence number | The test item content | Sort by |
| 1 | |
The T4 of |
Emergency treatment, hatched 14.7 |
| 2 | |
The FT3 of |
Emergency treatment, hatched 10 |
| 3 | |
The T3 of |
Common, hatch 14.7 minutes, test |
| 4 | |
The T4 of |
Common, hatch 14.7 minutes, test |
| 5 | |
The TSH-3 of |
Common, hatch 10 minutes, test |
| 6 | |
The TSH-3 of |
Common, hatch 10 minutes, test |
Then, according to three conditions in back, what can obtain these 6 test items hatches the part device control method, as shown in table 6 again.
Give an example 6 test items portion of hatching control method of testing together of son of table 6
More than be the explanation of hatching the part device control method of 6 test items, these 6 test items are produced by the situation that three samples carry out four kinds of checks.Carry out the situation of many test items that multiple check produced for other multisamples, can make uses the same method forms and hatches the part device control method accordingly.
Claims (6)
- A full-automatic chemical luminescence immunoassay appearance hatch part device, it is characterized in that the structure of this device comprises two disks, a main shaft, a main body and a shell up and down, last disk is to carry cup to coil; Be fixed on the main shaft upper end, can rotate around main shaft, lower disc is a positioning disk; When being fixed together with a year cup dish, positioning disk breaks away from main body, can follow a year glass dish and rotate; When being fixedly connected with main body, positioning disk is connected with a year glass dish through bearing, does not follow a year cup and coils rotation; The main shaft lower end is connected with main body through bearing, and shell is used to load main body, and is fixed together with the support body of full-automatic chemical luminescence immunoassay appearance.
- 2. full-automatic chemical luminescence immunoassay appearance according to claim 1 hatch part device, it is characterized in that carry the cup dish and comprise reaction cup dish and rotating disk, the reaction cup dish is used to load reaction cup, rotating disk is used for fixing several reaction cup dishes.
- 3. full-automatic chemical luminescence immunoassay appearance according to claim 1 hatch part device; It is characterized in that; Positioning disk comprises annulus, detent mechanism and magnetic stripe, is fixed with detent mechanism and magnetic stripe on the annulus, and detent mechanism is used for confirming the initial position of positioning disk; And making positioning disk and main body fix or break away from, magnetic stripe is used for the sample composition is washed separation.
- 4. full-automatic chemical luminescence immunoassay appearance according to claim 1 hatch part device; It is characterized in that; Main body comprises main cavity, pull bar, gear and drive motor; Pull bar is used to cooperate detent mechanism realization positioning disk to follow year cup dish rotation or keeps motionless, and gear and drive motor are used for driving year cup dish rotation.
- 5. a full-automatic chemical luminescence immunoassay appearance hatches the part device control method; It is characterized in that; Two kinds of controls are carried out in the rotation of cup dish and positioning disk to its year, and a kind of is to control by the set time beat to carry the position of glass dish with respect to a reaction cup of the each rotation of positioning disk, and another kind is that the control positioning disk is followed a year cup dish rotation together; Carry the each position of rotating a reaction cup of cup dish relative positioning dish by set time beat control; And utilize this mode to control the test item that arrives the magnetic wash separated region and accomplish incubation reaction just, and begin to carry out the reaction cup absolute position of incubation reaction, be certain fixed position of calculating according to the incubation reaction time of Interventions Requested; In the magnetic wash separated region, the reaction cup on the cleaning positions is carried out the magnetic wash lock out operation by the Interventions Requested requirement.
- 6. control method according to claim 5; It is characterized in that; Utilize positioning disk to follow to carry the control mode that the cup dish rotates together, the test item that carries out the sample check is carried out sample filling, reagent filling and loaded the operation of new reaction cup to position, reaction cup hole.
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| CN 201110452335 CN102565439B (en) | 2011-12-29 | 2011-12-29 | Incubation part device for full-automatic chemiluminescence immunity analyzer and control method for incubation part device |
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| CN 201110452335 CN102565439B (en) | 2011-12-29 | 2011-12-29 | Incubation part device for full-automatic chemiluminescence immunity analyzer and control method for incubation part device |
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Address after: 130012 Changchun province high tech Zone, the River Street, No. 95, No. Patentee after: Medical Polytron Technologies Inc Address before: 130012 Changchun province high tech Zone, the River Street, No. 95, No. Patentee before: Changchun Dirui Medical Technology Co., Ltd. |