JP2008026146A - Reaction panel, and specimen sampling unit equipped therewith - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a specimen-sampling unit wherein a reaction panel is separated from a blood drawing portion, capable of surely and readily performing spot contact of a specimen, for solving the problem, wherein conventional dry analysis elements are of blood collection portion integrated types, and spot adhesion of the specimen is difficult. <P>SOLUTION: The specimen-sampling unit 1 is set on a spot adhesive part 3, and moved to a mounting part by the rotation of a cartridge 2. Then, the specimen sampling unit is pushed down in the downward direction by a cylinder 5, and the specimen-sampling unit 1 is mounted on the reaction panel 7. Here, sure arrival becomes possible with the control in the vertical direction, without having to control in the horizontal direction. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention uses quantitative analysis of a physical quantity such as an optical density change or a potential change by a chemical reaction, a biochemical reaction, or an immune reaction with a predetermined biochemical substance contained in a body fluid sample such as blood or urine. The present invention relates to a biochemical analyzer that performs biochemical analysis.

  In recent years, a dry-type analytical element that can quantitatively analyze the content of a specific chemical component or its activity value, or the content of a formed component, by simply spotting and supplying a small droplet of the sample. Has been developed and put to practical use. (For example, Patent Document 1) As such a dry analysis element, a reaction panel carrying a dry reagent necessary for a chemical reaction, a multilayer analysis film, a filter paper type test piece, and a single layer or multilayer test piece improved therewith are also proposed. And some have been put to practical use.

  A plurality of types of dry analysis elements having different characteristics corresponding to measurement items are prepared, and a person who performs a test is arbitrarily selected according to a test, and after a sample is spotted on a blood collection site, the analysis is performed on the analyzer. Set and perform quantitative analysis. In addition, a mechanism has been devised and put into practical use for storing multiple types of dry analytical elements in a dedicated storage in the analyzer and managing them at the optimum temperature and humidity.

The mainstream method currently used for blood collection is a method in which a rice grain-sized blood that has pierced a microneedle into a subject's finger, palm, or the like is spotted on the blood collection site.
Japanese Patent Laid-Open No. 8-43405

  However, the conventional reaction panel is integrated with a blood collection site, and it is uneconomical that the entire reaction panel must be discarded if there is an error such as the minimum amount of specimen required for testing cannot be spotted at the time of blood collection. . Furthermore, there is a problem in that it becomes necessary to separate and process a site contaminated with a specimen.

  The present invention has been made to solve the conventional problems, and by separating the reaction panel and the sample collection unit, the waste of the reaction panel can be reduced, and the sample collection unit that can reliably join the reaction panel. The purpose is to provide.

  The blood collection unit of the present invention is a reaction panel having a sample collection unit and an assay unit to which the sample collection unit is attached, and performs position control only in the vertical direction when the sample collection unit is attached to the assay unit. The configuration is as follows.

  With this configuration, the control mechanism for communicating the sample collection unit with the reaction panel can be simplified and the communication can be ensured.

  Further, the sample collection unit of the reaction panel of the present invention is composed of at least a cylinder or a cone.

  With this configuration, it is not necessary to control the horizontal direction of both in communication with the sample collection unit, and communication can be performed only by control in the vertical direction. Furthermore, the sample collection unit of the present invention is configured by an open portion at one end and a sealed cylinder or cone at the other end. With this configuration, when a centrifugal force is applied in the direction of the sealed end of the sample collection unit, the sample collected inside the sample collection unit can move to the sample transfer channel of the reaction panel.

  The present invention ensures the communication with the reaction panel by providing a mechanism for mounting the sample collection unit on the reaction panel and a mechanism for preventing the displacement when the sample collection unit and the assay panel are communicated. It is possible to provide a sample collection unit that has the effects of facilitating wearing, eliminating waste of the reaction panel, and facilitating disposal of the blood collection site.

  Hereinafter, a blood collection unit according to an embodiment of the present invention will be described with reference to the drawings. In addition, although a specific example is given and this invention is demonstrated in detail, it is not limited at all by these.

  A blood collection unit according to the first embodiment of the present invention is shown in FIG.

  In FIG. 1, the blood collection unit of the present invention has a spotting portion 3 in a part of a cartridge 2 that stores a plurality of little finger large sample collection units 1. Is moved up and down by the control motor 6. The sample collection unit 1 is mounted on the reaction panel 7 and is confirmed by the communication detector 8.

  The operation of the blood collection unit of the present invention configured as described above will be described with reference to FIG.

  First, the sample collection unit 1 is set in the spotting unit 3, and the cartridge 2 is rotated and moved to the mounting unit. Next, the cylinder 5 pushes the sample collection unit downward, and the sample collection unit 1 is mounted on the reaction panel 7.

  Next, the communication part of the sample collection unit 1 and the reaction panel 7 of the second embodiment of the present invention is shown in FIG.

  FIG. 3 illustrates in detail the communication sites of the sample collection unit 1 and the reaction panel 7 (described in FIG. 1). The reaction panel communication portion 9 is slightly larger in diameter than the sample collection unit 1 and has a funnel shape, and communicates with the flow path 10. The sample collection unit 1 has a cylindrical shape and has a pore for allowing the sample to flow out at the tip, and a projection that is caught at the entrance of the reaction panel communicating portion is provided on the tail on the opposite side. When a sample is spotted on the tail and the sample collection unit 1 is mounted on the reaction panel 7 and a centrifugal force is applied downward, the sample flows out from the pores below the sample collection unit 1 and flows into the flow path 10. From the vent hole 11, the pressure when the sample flows into the communicating portion can be released.

  FIG. 4 explains the details of the sample collection unit 1. FIG. 4 is a diagram showing an upper surface, a side surface, and a cross section of the sample collection unit.

  The sample collection unit 1 has a cylindrical shape as shown in FIG. 4A and has one end narrowing toward the center of the bottom surface. The specimen is spotted on the upper surface, and the upper surface portion 12 has a larger diameter than the reaction panel communication portion 9. After the sample collection unit 1 communicates with the reaction panel 7, a centrifugal force is applied in the direction opposite to the upper surface portion 12, and the sample is transferred from the extraction hole 14 to the reaction panel communication portion 9. The specimen spotted on the upper surface portion 12 passes through the biological component separation filter 13 when moving to the extraction hole 14 by the action of centrifugal force. At this time, blood cell components and suspended matters are removed, and the purity of the target substance can be improved.

  Further, in the present embodiment, when the reaction panel and the sample collection unit are separated and used, it is possible to prevent the sample from leaking from the joint portion due to a shift in connection.

  As described above, a continuous supply of blood collection units is provided by providing a mechanism for mounting the sample collection unit on which the sample is deposited according to the present invention to the assay panel, and a mechanism for preventing a shift when the sample collection unit and the assay panel are communicated. It is possible to provide a sample collection unit that has the effects of ensuring communication with the reaction panel, facilitating sample spotting, eliminating waste of the analysis element and facilitating disposal of the blood collection site. Quantitative analysis of physical quantities such as optical density change or potential change by chemical reaction, biochemical reaction, immune reaction, etc. with a predetermined biochemical substance contained in body fluid samples such as blood, urine, etc. It is useful as a chemical analyzer.

The block diagram of the blood collection unit in the 1st Embodiment of this invention Flow chart of blood collection unit in the first embodiment of the present invention The front view of the sample collection unit and reaction panel communication part in the 2nd Embodiment of this invention The figure which shows the upper surface of the sample collection unit of this invention, a side surface, and a cross section

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Specimen collection unit 2 Cartridge 3 Spotting part 4 Control motor 5 Cylinder 6 Control motor 7 Reaction panel 8 Detector 9 Reaction panel communication part 10 Flow path 11 Vent hole 12 Upper surface part 13 Biological component separation filter 14 Extraction hole

Claims (3)

A reaction panel comprising a sample collection unit and an assay unit to which the sample collection unit is attached, wherein the position control is performed only in the vertical direction when the sample collection unit is attached to the assay unit. The reaction panel according to claim 1, wherein the sample collection unit is at least a cylinder or a cone. A sample collection unit, wherein one end is an open portion and the other end is a sealed cylinder or cone.

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