CN208588675U - Fully automatic chemiluminescence immunoassay analyzer - Google Patents
Fully automatic chemiluminescence immunoassay analyzer Download PDFInfo
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- CN208588675U CN208588675U CN201821176289.2U CN201821176289U CN208588675U CN 208588675 U CN208588675 U CN 208588675U CN 201821176289 U CN201821176289 U CN 201821176289U CN 208588675 U CN208588675 U CN 208588675U
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- chemiluminescence immunoassay
- lifting platform
- automatic chemiluminescence
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- 238000003018 immunoassay Methods 0.000 title claims description 30
- 238000004140 cleaning Methods 0.000 claims abstract description 102
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 82
- 238000002156 mixing Methods 0.000 claims abstract description 74
- 238000001514 detection method Methods 0.000 claims abstract description 38
- 238000005086 pumping Methods 0.000 claims abstract description 37
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 238000002347 injection Methods 0.000 claims abstract description 30
- 239000007924 injection Substances 0.000 claims abstract description 30
- 230000003287 optical effect Effects 0.000 claims abstract description 28
- 238000010438 heat treatment Methods 0.000 claims description 25
- 230000005540 biological transmission Effects 0.000 claims description 23
- 230000007246 mechanism Effects 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 22
- 238000003825 pressing Methods 0.000 claims description 8
- 238000005096 rolling process Methods 0.000 claims description 3
- 238000005485 electric heating Methods 0.000 claims 1
- 230000003749 cleanliness Effects 0.000 abstract 1
- 230000037452 priming Effects 0.000 description 36
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 23
- 238000004458 analytical method Methods 0.000 description 18
- 239000011148 porous material Substances 0.000 description 16
- 230000005693 optoelectronics Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 10
- 230000007423 decrease Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003028 elevating effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 238000004321 preservation Methods 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
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- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
本实用新型公开了一种全自动化学发光免疫分析仪，涉及医疗器械技术领域。该分析仪包括底座，底座上设置有清洗混匀装置和光学检测装置，清洗混匀装置包括清洗盘、用于驱动清洗盘旋转的第一驱动装置以及位于清洗盘上方的抽液装置、注液装置和混匀装置，底座上还设置有用于驱动注液装置、抽液装置和混匀装置在竖直方向上上下运动的升降装置；混匀装置包括用于抓取试剂管的抓手和驱动抓手旋转的第二驱动装置；清洗盘的上端面设置有均匀分布的放管孔，清洗盘的外缘上设置有与放管孔相连通的光学检测孔；光学检测装置包括设置于底座上并且靠近清洗盘外缘的光子计数器。本实用新型既能提高清洗洁净度和清洗效率，又能提高检测效率和检测准确度。
The utility model discloses an automatic chemiluminescence immune analyzer, which relates to the technical field of medical devices. The analyzer includes a base, and a cleaning and mixing device and an optical detection device are arranged on the base. The cleaning and mixing device includes a cleaning disk, a first driving device for driving the rotation of the cleaning disk, and a liquid pumping device located above the cleaning disk. device and mixing device, the base is also provided with a lifting device for driving the liquid injection device, the liquid suction device and the mixing device to move up and down in the vertical direction; the mixing device includes a gripper for grasping the reagent tube and a driving device The second driving device for the rotation of the gripper; the upper end face of the cleaning disk is provided with evenly distributed pipe-releasing holes, and the outer edge of the cleaning disk is provided with an optical detection hole that communicates with the pipe-releasing holes; the optical detection device includes And a photon counter near the outer edge of the cleaning disk. The utility model can not only improve cleaning cleanliness and cleaning efficiency, but also improve detection efficiency and detection accuracy.
Description
Technical field
The utility model relates to the field of medical instrument technology, and in particular to a kind of Full-automatic chemiluminescence immunoassay analysis meter.
Background technique
Chemiluminescence immunoassay technology (Chemiluminescence immunoassay, abbreviation CLIA) is current generation
Develop very fast on-radiation immuno analytical method within the scope of boundary, have high sensitivity, high specificity, the range of linearity it is wide,
The advantageous features such as the degree of automation height, it has also become the main means of clinical diagnosis.
Most of Full-automatic chemiluminescence analyzers are generally by manipulator or chain type transmission mechanism, reagent sample currently on the market
Product part incubates the compositions such as part, cleaning part, the detection structure that shines.In detection process, in general, Reagent Tube is loaded this, adds
The clamping of sample reaction tube is transferred to cleaning position by manipulator after the completion of incubation by magnetic bead, reagent adding, is carried out Magneto separate, cleaning, is mixed
Even, note luminous substrate, then luminous check bit is transferred to by transmission mechanism and is detected.Wherein, the cleaning of Reagent Tube and reagent
Blending process has most direct influence for illumination effect, and cleaning and being not thorough for mixing often will cause illumination effect not
The problems such as stabilization, testing result is distorted.One detection process needs to carry out repeatedly transfer operation, sample by manipulator crawl reaction tube
Often there is the excessive loss of temperature and energy during transfer and the problems such as reaction be not thorough in this reaction tube, in some instances it may even be possible to wrong
Optimal luminescent detection opportunity is spent, causes test result error larger or the problems such as testing result is unstable；In addition, reaction tube is excessive
Crawl, placement movement easily cause test reliability and testing efficiency reduce the problem of.
Utility model content
The utility model provides one kind and can improve cleaning degree and cleaning efficiency and improve detection efficiency and detection
The Full-automatic chemiluminescence immunoassay analysis meter of accuracy.
In order to solve the above technical problems, the utility model offer technical solution is as follows:
A kind of Full-automatic chemiluminescence immunoassay analysis meter, including pedestal, be provided on the pedestal cleaning evenly mixing device and
Optical detection apparatus, in which:
The cleaning evenly mixing device includes the cleaning disk being set on the pedestal, for driving the cleaning disc spins
First driving device and pumping device, priming device and evenly mixing device above the cleaning disk, on the pedestal also
It is provided with the lifting device for driving the priming device, pumping device and evenly mixing device to move up and down in the vertical direction；
The pumping device, priming device and evenly mixing device difference at least two；
The evenly mixing device includes for grabbing the handgrip of Reagent Tube and driving the second driving device of the handgrip rotation；
The upper surface of the cleaning disk be provided with it is equally distributed put pore, be provided in the outer rim of the cleaning disk and institute
It states and puts the optical inspection hole that pore is connected；
The optical detection apparatus includes being set on the pedestal and close to the photon counting of the cleaning disk outer rim
Device.
Further, the lifting device includes the first spiral lift being set on the pedestal and is set to described
First hoistable platform of the output end of the first spiral lift, first hoistable platform are located at the top of cleaning disk, the pumping
Liquid device, priming device and evenly mixing device are arranged on first hoistable platform.
Further, the first guiding device, institute are additionally provided between first spiral lift and the first hoistable platform
The first guiding device is stated using guide rail slide block transmission mechanism, Worm and worm-wheel gearing or rack and pinion drive mechanism.
Further, the shaft being fixedly connected with the handgrip is provided on the pedestal, between the shaft and pedestal
It is connected using rolling bearing, second driving device includes the first motor being set on first hoistable platform, setting
The first driving wheel in the output end of the first motor and the first driven wheel for being fixedly connected with the shaft, described first is main
Using the first transmission band connection between driving wheel and the first driven wheel.
Further, the handgrip is made of flexible casing, is uniformly arranged in the lower end outer rim of described sleeve pipe
There is the open slot being connected to the inner wall of described sleeve pipe.
Further, the bottom end of described sleeve pipe is provided with conical opening.
Further, the end face of the shaft is provided with first through hole, is provided in the first through hole and shaft gap
The push pipe set of cooperation, is additionally provided with pipe pressing device on first hoistable platform, and the pipe pressing device includes being set to described the
The second spiral lift on one hoistable platform and the second hoistable platform being connect with the output end of second elevator, it is described
The pressure pipe piece positioned at push pipe set top is provided on second hoistable platform.
Further, the injection needle of the handgrip and priming device is coaxially disposed, and the injection needle is arranged in the push pipe
The inner hole of set.
Further, the second guiding device is provided between first hoistable platform and the second hoistable platform；
Second guiding device includes guide rod, is provided on second hoistable platform and matches with the guide rod gap
The guide sleeve of conjunction；
Alternatively, second guiding device uses guide rail slide block transmission mechanism, Worm and worm-wheel gearing or gear teeth
Strip transmission mechanism.
Further, it is provided with Electric radiant Heating Film on the inner wall of the cleaning disk, is provided on the pedestal and adds for cleaning solution
The pipeline heating structure of heat and the luminous substrate heating structure heated for luminous substrate.
Compared with prior art, the utility model has the following beneficial effects:
At least two pumpings are respectively set above cleaning disk in the Full-automatic chemiluminescence immunoassay analysis meter of the utility model
Liquid device, priming device and evenly mixing device, and optical detection apparatus is being set close to the position of cleaning disk outer rim.One of note
Liquid device and evenly mixing device are used for the injection and mixing of substrate, remaining pumping device, priming device and evenly mixing device are for trying
The cleaning of agent pipe.First driving device can control cleaning disc spins certain angle and the Reagent Tube cleaned in disk reached accordingly
Pumping device, carry out cleaning mixing below priming device (evenly mixing device), and the lower section of the last one priming device into
The filling of row substrate and mixing.Last first driving device control cleaning disc spins certain angle arrives the Reagent Tube cleaned in disk
Up to the corresponding position of optical detection apparatus, by optical detection apparatus through the optical inspection hole in cleaning disk outer rim in Reagent Tube
Reactant detected.In the Full-automatic chemiluminescence immunoassay analysis meter of the utility model, by the way that evenly mixing device is arranged, and
The handgrip of evenly mixing device and the injection needle of priming device are coaxially disposed, and are increased the rotation to Reagent Tube in cleaning reagent pipe and are mixed
Step improves the cleaning degree and cleaning efficiency of Reagent Tube.In addition, the utility model is by the way that optical detection apparatus to be arranged
In the position close to cleaning disk outer rim, and it is arranged in the outer rim of cleaning disk and the optical inspection hole putting pore and be connected, reagent
Reagent Tube in disk need to only rotate a certain angle under the control of first driving device reaches optical detection position, by optics
The optical inspection hole that the photon counter of detection device is directly based upon on cleaning disk carries out photon reading detection, avoids Reagent Tube
The mobile energy consumption generated and transfer error after substrate filling, and there is no cross contamination risk, reduce photon reading
Number error, improves detection efficiency and accuracy in detection, ensure that the reliability of testing result.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the Full-automatic chemiluminescence immunoassay analysis meter of the utility model；
Fig. 2 is the bottom substance schematic diagram of the Full-automatic chemiluminescence immunoassay analysis meter of the utility model；
Fig. 3 is the structural schematic diagram that evenly mixing device is cleaned in the Full-automatic chemiluminescence immunoassay analysis meter of the utility model；
Fig. 4 is the structural schematic diagram of evenly mixing device in the Full-automatic chemiluminescence immunoassay analysis meter of the utility model.
Specific embodiment
In order to make the technical problems, technical solutions and advantages to be solved by the utility model clearer, below in conjunction with attached drawing
And specific embodiment is described in detail.
The utility model provides a kind of Full-automatic chemiluminescence immunoassay analysis meter, as shown in Figures 1 to 4, including pedestal 1,
Cleaning evenly mixing device and optical detection apparatus 10 are provided on pedestal, in which:
Cleaning evenly mixing device includes the cleaning disk 2 being set on pedestal 1, the first driving for driving cleaning disk 2 to rotate
Device 3 is additionally provided on pumping device 6, priming device 5 and the evenly mixing device 4 cleaned above disk 2, pedestal 1 for driving
The lifting device 7 that priming device 5, pumping device 6 and evenly mixing device 4 move up and down in the vertical direction；
Pumping device 6, priming device 5 and the difference of evenly mixing device 4 at least two；
Evenly mixing device 4 includes for grabbing the handgrip 4-1 of Reagent Tube and driving the second driving device 4- of handgrip 4-1 rotation
2；
The upper surface of cleaning disk 2 be provided with it is equally distributed put pore 2-1, clean in the outer rim of disk 2 and be provided with and put pipe
The optical inspection hole 2-2 that hole 2-1 is connected；
Optical detection apparatus 10 includes being set on pedestal 1 and close to the photon counter 10-1 of cleaning 2 outer rim of disk.
In the Full-automatic chemiluminescence immunoassay analysis meter of the utility model, when initial position, lifting device 7 controls drawing liquid dress
It sets 6, priming device 5 and evenly mixing device 4 rises the top for making it be fully located at cleaning disk 2.Pass through wait the Reagent Tube after incubating
Manipulator is put into after cleaning disk 2, and the control cleaning disk 2 of first driving device 3 rotates by a certain angle so that Reagent Tube reaches drawing liquid
The lower section of device 6, lifting device 7 controls the waste liquid extraction in the lower general who has surrendered's Reagent Tube of pumping device 6 at this time, later lifting device 7
It controls pumping device 6 to rise, first driving device 3 controls cleaning disk 2 again and rotates by a certain angle so that Reagent Tube reaches fluid injection
The lower section of device 5 and evenly mixing device 4, lifting device 7 controls priming device 5 and evenly mixing device 4 and declines at this time, priming device 5 to
Cleaning solution is injected in Reagent Tube, the handgrip 4-1 of evenly mixing device 4 grabs Reagent Tube, and lifting device 7 controls 5 He of priming device later
Evenly mixing device 4 rises so that Reagent Tube is detached from cleaning disk 2 and puts pore 2-1, rear drive equipment control handgrip 4-1 rotation, examination
Agent pipe rotates under the crawl effect of handgrip 4-1, thus completes the mixing cleaning in Reagent Tube, improves Reagent Tube
Cleaning degree.After Reagent Tube cleans, the driving cleaning disk 2 of first driving device 3 turns an angle so that Reagent Tube reaches separately
The lower section of one pumping device 6, elevating mechanism drive pumping device 6 decline extract Reagent Tube in waste liquid, rear lifting mechanism drive
Dynamic pumping device 6 rises, and the driving cleaning disk 2 of first driving device 3 turns an angle so that Reagent Tube reaches another fluid injection dress
5 lower section is set, elevating mechanism drives priming device 5 to decline, and priming device 5 injects substrate into Reagent Tube, and evenly mixing device 4 is grabbed
Hand 4-1 grabs Reagent Tube, and lifting device 7 controls priming device 5 later and evenly mixing device 4 rises, so that Reagent Tube is detached from cleaning
Disk 2 puts pore 2-1, rear drive equipment control handgrip 4-1 rotation, Reagent Tube handgrip 4-1 crawl effect under rotate, by
This completes mixing work of the substrate in Reagent Tube.The cleaning disk 2 of the driving of first driving device 3 later turns an angle so that trying
Agent pipe reaches the corresponding position of optical detection apparatus 10, is detected by optical detection apparatus 10 to the reactant in Reagent Tube.
To sum up, the Full-automatic chemiluminescence immunoassay analysis meter of the utility model is by setting evenly mixing device 4, and mixes dress
It sets 4 handgrip 4-1 and the injection needle of priming device 5 is coaxially disposed, inject cleaning solution into Reagent Tube in priming device 5 and shine
Reagent Tube is rotated by evenly mixing device 4 after substrate, cleaning solution is adequately cleaned to Reagent Tube, reagent
The cleaning of pipe is more thorough, and cleaning efficiency also increases accordingly；And the mixing function of passing through evenly mixing device 4, accelerates luminous bottom
Chemical reaction of the object in Reagent Tube.In addition, the utility model is by the way that optical detection apparatus 10 to be positioned close to outside cleaning disk 2
After the control cleaning disk 2 of first driving device 3 rotates by a certain angle, luminous substrate can be added by cleaning in the position of edge in disk 2
Reagent Tube is transferred to optical detection position, and the photon counter 10-1 of optical detection apparatus 10 is through the optical detection for cleaning disk 2
Hole 2-2 can to the luminous substrate in Reagent Tube carry out count detection, thereby reduce luminous substrate be added Reagent Tube move back to
The distance at optical detection position avoids Reagent Tube and generates energy consumption during the transfers such as crawl, placement, improves detection
Efficiency reduces the error of photon reading, ensure that testing result.
In an embodiment of the present invention, first driving device 3 can be driven clearly by the way of motor driven transmission belt
Dishwashing 2 rotates, specifically, as shown in Fig. 2, first driving device 3 may include the first motor 3- being fixed on pedestal 1
1, it the first driving pulley 3-2 for being fixedly connected with the output end of first motor 3-1 and is fixedly connected with cleaning disk 2 first driven
Belt wheel 3-4 uses the first transmission belt 3-3 connection between the first driving pulley 3-2 and the first driven pulley 3-4.Here first
Transmission belt 3-3 can use the structure type of synchronous belt to improve the transmission accuracy of first driving device 3.
Certainly, first driving device 3 can also be driven other than using the structure type of motor driven transmission belt using motor
Moving gear engagement frame mode come realize its to cleaning disk 2 rotation control.
In addition, the Reagent Tube after incubating is put into before cleaning disk 2, a certain pore 2-1 of putting for needing to control cleaning disk 2 is arrived
Up to specified position, in order to which Reagent Tube is put into pore 2-1.Determining that this puts whether pore 2-1 reaches specified position,
It can use and be arranged the first optoelectronic switch 3-5's and the first optoelectronic switch baffle 3-6 on pedestal 1 and the first driven pulley 3-4
Structure type.When needs are to when putting placement Reagent Tube in pore 2-1, first motor 3-1 controls the first driving pulley 3-2 rotation,
Cleaning disk 2 is driven to rotate from there through the first driven pulley 3-4, when the first optoelectronic switch 3-5 enters the first optoelectronic switch baffle
When the sensed position of 3-6, the first optoelectronic switch 3-5 transmits the signal to the control system of Full-automatic chemiluminescence immunoassay analysis meter
System, control system control first motor 3-1 according to the signal and stop operating, this is put pore 2-1 and reaches specified position, it
Reagent Tube can be put into this to put pore 2-1 subsequent clear to carry out by other mechanisms of Full-automatic chemiluminescence immunoassay analysis meter afterwards
It washes, detect work.
In an embodiment of the present invention, optical detection apparatus 10 is other than including photon counter 10-1, in order to subtract
Few influence of the external light source to the luminous substrate in Reagent Tube, can be respectively set barn door in the two sides of photon counter 10-1
10-2 blocks light source.
In an embodiment of the present invention, lifting device 7 can control drawing liquid using the structure type of spiral lift
The lifting of device 6, priming device 5 and evenly mixing device 4 relative to cleaning disk 2.Specifically, lifting device 7 preferably includes to be set to
The first hoistable platform 7-2 of the first spiral lift 7-1 and the output end for being set to the first spiral lift 7-1 on pedestal 1,
First hoistable platform 7-2 is located at the top of cleaning disk 2, and pumping device 6, priming device 5 and evenly mixing device 4 are arranged at first liter
It drops on platform 7-2.When the first spiral lift 7-1 energization rotation and lifting, by the first hoistable platform 7-2 control pumping device 6,
Priming device 5 and evenly mixing device 4 are gone up and down simultaneously.
Wherein, pumping device 6 may include liquid pumping needle 6-1 and the liquid pumping needle that is fixedly connected on the first hoistable platform 7-2
Support 6-2, liquid pumping needle 6-1 are fixed on liquid pumping needle support 6-2 by fastening screw.When the first hoistable platform 7-2 is in the first spiral shell
When going up and down under the control of rotation elevator 7-1, it is dynamic that liquid pumping needle 6-1 can carry out drawing liquid relative to the Reagent Tube lifting in cleaning disk 2
Make.
Priming device 5 also may include injection needle 5-1 and the injection needle support that is fixedly connected on the first hoistable platform 7-2
5-2, injection needle 5-1 are fixed on injection needle support 5-2.When the first hoistable platform 7-2 is in the control of the first spiral lift 7-1
When lower lifting, injection needle 5-1 can carry out fluid injection movement relative to the Reagent Tube lifting in cleaning disk 2.
During the utility model one is implemented, the quantity of pumping device 6, priming device 5 and evenly mixing device 4 is respectively three, ring
Shape is arranged on the first hoistable platform 7-2, and 6, priming devices 5 of a pumping device and an evenly mixing device 4 form a set of
Mix structure, wherein two sets mix the cleaning that structure is used for Reagent Tube, last a set of injection for mixing structure and being used for luminous substrate
And mixing.The utility model mixes structure by the more sets of setting and further improves Reagent Tube by the way that Reagent Tube is cleaned multiple times
Cleaning degree, and luminous substrate directly is injected to Reagent Tube in cleaning disk 2 after Reagent Tube cleaning, it avoids Reagent Tube and exists
Cross contamination is generated during crawl, transfer, improves detection accuracy.
In an embodiment of the present invention, the outer fringe position on pedestal 1 close to cleaning disk 2 is additionally provided with multiple strong magnetic devices
9, each pumping device 6, priming device 5 and evenly mixing device 4 respectively correspond one strong magnetic device 9.When cleaning disk 2 rotates certain angle
When Reagent Tube is transferred to the lower section of pumping device 6, priming device 5 and evenly mixing device 4 by degree, the magnetic bead in Reagent Tube is based on strong magnetic
The magnetism of device 9, is attracted on the inner wall of Reagent Tube, guarantees that the liquid pumping needle 6-1 of pumping device 6 will not be by magnetic bead in drawing liquid
Extract Reagent Tube out.
Preferably, in order to improve stability of the first hoistable platform 7-2 in lifting process, the first spiral lift 7-1
The first guiding device 7-3, the first guiding device 7-3 is also provided between the first hoistable platform 7-2 can use guide rail
Any structure form in slider driving gear, Worm and worm-wheel gearing and rack and pinion drive mechanism, may be implemented pair
The guiding role of first hoistable platform 7-2.
When the first guiding device 7-3 uses the form of guide rail slide block transmission mechanism, the first guiding device 7-3 is preferably included
The guide rail being set on pedestal 1 and the sliding block for being set to the output end of the first spiral lift 7-1 and being slidably connected with guide rail.
In addition, when pumping device 6, priming device 5 and evenly mixing device 4 decline under the control of the first spiral lift 7-1,
The height that liquid pumping needle 6-1, injection needle 5-1 and handgrip 4-1 decline in order to prevent is too low to damage Reagent Tube, can be in guide rail
With the second optoelectronic switch 7-5 and the second optoelectronic switch baffle 7-4 are respectively set on sliding block.When the first spiral lift 7-1 drives
Pumping device 6, priming device 5 and evenly mixing device 4 decline so that liquid pumping needle 6-1, injection needle 5-1 and handgrip 4-1 are reached suitably
When height, when the second optoelectronic switch 7-5 enters the sensed position of the second optoelectronic switch baffle 7-4, Full-automatic chemiluminescence is immune
The control system of analyzer controls under the first spiral lift 7-1 stopping according to the signal of the second optoelectronic switch 7-5 received
Drop, pumping device 6, priming device 5 and evenly mixing device 4 carry out corresponding drawing liquid, fluid injection and mixing movement later.
In an embodiment of the present invention, pumping device 6, priming device 5 and evenly mixing device 4 are fixedly connected sequentially first
On hoistable platform 7-2, wherein injection needle 5-1 and handgrip 4-1 can both respectively correspond two and put pore 2-1, and injection needle 5-1 is to examination
In agent pipe after fluid injection, priming device 5 is controlled by lifting device 7 and is risen, the cleaning disk 2 of the control of first driving device 3 later rotates
Certain angle makes the Reagent Tube reach the lower section of handgrip 4-1, and lifting device 7 controls the decline of evenly mixing device 4 by handgrip 4-1 again later
Reagent Tube is caught to carry out mixing movement.
Other than above structure mode, injection needle 5-1 and handgrip 4-1 can also be coaxially disposed and put pipe so that correspondence is same
Hole 2-1.Specifically, handgrip 4-1 can be connect by shaft 4-3 with pedestal 1, and the axis of rolling is used between shaft 4-3 and pedestal 1
4-4 connection is held, it is possible thereby to guarantee that handgrip 4-1 can be rotated relative to its axis.At this point, use need to be arranged in the end face of shaft 4-3
In the first through hole for the injection needle 5-1 for passing through priming device 5, the second driving device 4-2 can also be using motor driven belt wheel
Frame mode controls handgrip 4-1 rotation, specifically, the second driving device 4-2 may include being set on the first hoistable platform 7-2
The second motor 4-2-1, the second driving wheel 4-2-2 for being connect with the output end of the second motor 4-2-1 and with shaft 4-3 is fixed connects
The the second driven wheel 4-2-4 connect is connected between the second driving wheel 4-2-2 and the second driven wheel 4-2-4 using the second transmission belt 4-2-3
It connects.
Further, since there is multiple Reagent Tubes and mixing mechanism in cleaning disk 2, multiple Reagent Tubes can be carried out simultaneously clear
Wash mixing.Under this structure type, in order to reduce cost, a second motor 4-2-1 can be used by changing hands for adjacent two
It is driven, specifically, the second transmission belt 4-2-3 can connect the second driving wheel 4-2-2 and two the second driven wheel 4- simultaneously
After 2-4, the second motor 4-2-1 start work, the second driving wheel 4-2-2 drives two by the second transmission belt 4-2-3 of driving
Second driven wheel 4-2-4 rotation, rotation while being achieved in two handgrip 4-1.
Further, handgrip 4-1 is preferably made of flexible casing, is evenly arranged in the lower end outer rim of casing
The open slot 4-1-1 being connected to the inner wall of casing.When declining under control of the handgrip 4-1 in lifting device 7, due to the bullet of casing
Property effect and open slot 4-1-1 setting, the upper end of Reagent Tube is directly inserted into the inner wall of casing, is fixed on casing later
Inner hole in.
Preferably, when lifting device 7 drives handgrip 4-1 decline, in order to make the upper end more smooth sleeve pipe of Reagent Tube
Conical opening has can be set in the bottom end of inner hole, casing, and the lower end diameter of the conical opening is greater than the diameter of bore of casing.
After evenly mixing device 4 is to the liquid blending in Reagent Tube, lifting device 7 controls general who has surrendered's Reagent Tube under handgrip 4-1 and puts
It is back to and puts pore 2-1, since handgrip 4-1 cannot individually complete the function that Reagent Tube is returned to pore 2-1, pressure pipe is needed to fill
It sets 11 mate-assists and takes out Reagent Tube from handgrip 4-1.Specifically, can be arranged in the first through hole of shaft 4-3 and turn
The push pipe of axis 4-3 clearance fit covers 4-5, and pipe pressing device 11 is arranged on the first hoistable platform 7-2, and pipe pressing device 11 preferably includes
It the second spiral lift 11-1 for being set on the first hoistable platform 7-2 and is connect with the output end of the second spiral lift 11-1
The second hoistable platform 11-2, the second hoistable platform 11-2 on be provided with positioned at push pipe set 4-5 above pressure pipe piece 11-3.When
When two spiral lift 11-1 control decline of the second hoistable platform 11-2 with dynamic pressure tube piece 11-3, pressure pipe piece 11-3 and push pipe set
The upper-end contact of 4-5 simultaneously pushes push pipe set 4-5 to move downward, and after push pipe set 4-5 moves downward certain distance, push pipe covers 4-5's
The upper end of lower end in contact Reagent Tube, when pressure pipe piece 11-3 continues to move downward, Reagent Tube moves back under the impetus of push pipe set 4-5
The inner hole of casing, which drops down onto, out puts pore 2-1, and handgrip 4-1 rises under the drive of lifting device 7 later, thus completes Reagent Tube
It places.
In addition, can also include being respectively arranged at the first hoistable platform 7-2 and the second hoistable platform 11- on pipe pressing device 11
Third optoelectronic switch baffle 11-6 and third optoelectronic switch baffle 11-6 baffle on 2, when the second spiral lift 11-1 is controlled
When second hoistable platform 11-2 drops to certain height relative to the first hoistable platform 7-2, third optoelectronic switch baffle 11-6
Into third photoswitc baffle sensed position when, the control system of Full-automatic chemiluminescence immunoassay analysis meter is according to receiving
Third optoelectronic switch baffle 11-6 signal control the second spiral lift 11-1 stop decline, pressure pipe piece 11-3 can be prevented
Reagent Tube is crushed because falling head is too low.
Likewise, the second spiral lift 11-1 control the second hoistable platform 11-2 lifting when, in order to improve second liter
Stability of the platform 11-2 in lifting process drops, between the second spiral lift 11-1 and the second hoistable platform 11-2 it is also preferred that
Guide rail slide block transmission mechanism, Worm Wheel System can be used by being provided with the second guiding device 11-4, the second guiding device 11-4
Any structure form in mechanism and rack and pinion drive mechanism may be implemented to make the guiding of the second hoistable platform 11-2
With.
Certainly, as shown in figure 3, the second guiding device 11-4 can also be using the structure side of guide rod and guide sleeve cooperation
Formula, wherein guide sleeve can be set on the first hoistable platform 7-2, be arranged on the second hoistable platform 11-2 and match with guide sleeve gap
The guide rod of conjunction.
In an embodiment of the present invention, by temperature change during transfer in cleaning disk 2 in order to avoid Reagent Tube
Influence, and then lead to the inaccuracy of testing result, Electric radiant Heating Film such as PI Electric radiant Heating Film can be set on the inner wall of cleaning disk 2,
The setting of Electric radiant Heating Film can be used for simulating human body temperature, ensure that Reagent Tube is not acted upon by temperature changes.
Further, it is also possible to which setting is for the pipeline heating structure 8 of cleaning solution heating and for substrate heating on pedestal 1
Luminous substrate heating structure.Wherein pipeline heating structure 8 is identical with luminous substrate heating structure, includes heating inner core and heating
Outer wall, for heating inner core for fixing pipeline and thermally conductive, heating outer wall is provided with Electric radiant Heating Film, and is surrounded by heat-preservation cotton.Pipeline heating knot
Structure 8 and luminous substrate heating structure are separately fixed on pedestal 1 by using end cap made of POM material, ensure that thermal insulation,
Improve heating efficiency.
In conclusion the Full-automatic chemiluminescence immunoassay analysis meter of the utility model cleans multistep, mixing and optics are examined
Three kinds of function sets are surveyed as integrated system, the structural complexity of analyzer is reduced, improves structural reliability, and reduce
The whole manufacturing cost of analyzer；The multistep cleaning of the utility model, blending manner ensure that cleaning effect, can carry out simultaneously
Cleaning, the mixing movement of multiple Reagent Tubes, improve the reaction speed of cleaning efficiency and luminous substrate；The structure of integral system
Form avoids Reagent Tube and generates transfer error and energy consumption during transfer, and does not have cross contamination, reduces light
Sub- error in reading, improves testing efficiency, ensure that the reliability of testing result.
The above is preferred embodiments of the present invention, it is noted that for the ordinary skill of the art
For personnel, under the premise of not departing from principle described in the utility model, it can also make several improvements and retouch, these improvement
It also should be regarded as the protection scope of the utility model with retouching.
Claims (10)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821176289.2U CN208588675U (en) | 2018-07-24 | 2018-07-24 | Fully automatic chemiluminescence immunoassay analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821176289.2U CN208588675U (en) | 2018-07-24 | 2018-07-24 | Fully automatic chemiluminescence immunoassay analyzer |
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| CN208588675U true CN208588675U (en) | 2019-03-08 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108732163A (en) * | 2018-07-24 | 2018-11-02 | 山东博科诊断科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN114152738A (en) * | 2021-12-01 | 2022-03-08 | 赛乐进（绍兴）科技有限公司 | Immunoblotting instrument |
-
2018
- 2018-07-24 CN CN201821176289.2U patent/CN208588675U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108732163A (en) * | 2018-07-24 | 2018-11-02 | 山东博科诊断科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN108732163B (en) * | 2018-07-24 | 2024-08-16 | 山东博科诊断科技有限公司 | Fully automatic chemiluminescence immunoassay analyzer |
| CN114152738A (en) * | 2021-12-01 | 2022-03-08 | 赛乐进（绍兴）科技有限公司 | Immunoblotting instrument |
| CN114152738B (en) * | 2021-12-01 | 2022-07-12 | 赛乐进（绍兴）科技有限公司 | Immunoblotting instrument |
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