CN110849701B

CN110849701B - Sample processing apparatus

Info

Publication number: CN110849701B
Application number: CN201911067112.8A
Authority: CN
Inventors: 佟艳会; 曹玉峰
Original assignee: Shandong Jianwei Biological Technology Co ltd
Current assignee: Shandong Jianwei Biological Technology Co ltd
Priority date: 2019-11-04
Filing date: 2019-11-04
Publication date: 2023-02-28
Anticipated expiration: 2039-11-04
Also published as: CN110849701A

Abstract

The present disclosure relates to a sample processing apparatus, comprising a rack; a syringe including a tubular housing having opposite operating and plunger ends, the housing being disposed in the chassis and having opposite first and second ends, the plunger end projecting into the housing from the first end, the plunger rod being movable relative to the housing to extend and retract, the needle being detachably and airtightly connected to the second end to draw a sample into the needle by extension of the plunger rod and to expel the sample from the needle by retraction of the plunger rod; the heating device is a non-contact heating device, is arranged on the rack and comprises a thermal radiation source, the thermal radiation source is limited with a thermal radiation heating area, at least one part of a needle tube connected with the shell is limited with a to-be-heated area of the sample, and the to-be-heated area is positioned in the thermal radiation heating area. The present disclosure provides a sample processing apparatus capable of improving work efficiency and easily controlling the temperature of a sample.

Description

Sample processing apparatus

Technical Field

The present disclosure relates to the field of sample processing techniques, and in particular, to a sample processing device.

Background

Based on the needs of biological sample (hereinafter simply referred to as sample) analysis, it is sometimes necessary to heat the sample to a desired temperature during the processing of the biological sample.

In the related art, the heating of the sample is generally realized by heat exchange between the heating block and a container for holding the sample, such as a needle tube or a consumable, and during operation, a certain time is required for heating the heating block to a desired temperature, and a certain time is also required for cooling the heating block to the desired temperature. Therefore, different steps require different temperatures in the process of processing the sample, and therefore, the temperature of the heating block needs to be raised and lowered repeatedly, and therefore, a certain time period for raising and lowering the temperature is required. Therefore, not only the operation efficiency is reduced, but also it is difficult to control the rise of the sample temperature, which may affect the accuracy of sample analysis.

Disclosure of Invention

An object of the present disclosure is to provide a sample processing apparatus capable of improving work efficiency and easily controlling the temperature of a sample.

In order to achieve the above object, the present disclosure provides a sample processing apparatus including: a frame; a syringe including a tubular housing having opposite operating and plunger ends, the housing being disposed on the chassis and having opposite first and second ends, the plunger end projecting into the housing from the first end, the plunger rod being movable relative to the housing to extend and retract, a needle tube being detachably and hermetically connected to the second end to draw a sample into the needle tube by the extension of the plunger rod and to expel the sample from the needle tube by the retraction of the plunger rod; the heating device is a non-contact heating device and comprises a thermal radiation source, the thermal radiation source is limited with a thermal radiation heating area, at least one part of the needle tube connected with the shell is limited with a to-be-heated area of the sample, and the to-be-heated area is positioned in the thermal radiation heating area.

Optionally, the frame comprises a basic support, the housing is fixed to the front face of the basic support, and the heating device is movably connected to the basic support to be capable of adjusting the position relative to the basic support, so that the thermal radiation heating area covers the area to be heated.

Optionally, the axis of the syringe extends generally in the Z-direction of the sample processing device, the sample processing device comprising a position adjustment mechanism that drives movement of the heating arrangement relative to the base support in the Z-direction.

Optionally, the position adjusting mechanism includes a driving motor and a transmission structure, the driving motor is fixed to the base bracket, and the heating device is connected to an output of the driving motor through the transmission structure.

Optionally, the output of the driving motor is configured as an output shaft, and the transmission structure is configured as a motion conversion structure to convert the rotational motion of the output shaft into a linear motion of the heating device in the Z direction.

Alternatively, the transmission structure includes a rocker arm having a start end and a tail end opposite to each other, the start end being fixed to the output shaft, a roller being pivotally provided at the tail end, an extending direction of the rocker arm from the start end to the tail end being substantially perpendicular to an axis of the output shaft, and a link bracket extending substantially in a Y direction of the sample processing apparatus and provided with a long hole extending substantially in the Y direction, the roller being fitted in the long hole and being movable in the long hole in the Y direction, the heating device being fixed with respect to the link bracket.

Optionally, the sample processing device further comprises a guide mechanism, the guide mechanism comprises a Z-directional guide rail arranged on the back surface of the basic bracket and a sliding bracket which is matched on the guide rail and can slide along the guide rail, and the sliding bracket is connected with the connecting bracket.

Optionally, the guide mechanism is provided with two sets, the two sets of guide mechanisms are arranged at intervals along the Y direction, the sliding supports in the two sets of guide mechanisms are connected through the connecting support, and the heating device is connected to the lower ends of the two sliding supports.

Optionally, the sample processing apparatus further includes a position detection device and a control unit, the position detection device is configured to detect a position of the heating device in the Z direction relative to the base support, the position detection device and the position adjustment mechanism are both in communication connection with the control unit, and the control unit controls the position adjustment mechanism to drive the heating device to move to enable the thermal radiation heating area to cover the area to be heated according to a position signal detected by the position detection device.

Optionally, the rack comprises a vertical column extending along the Z direction, and the basic bracket can be driven to move up and down along the Z direction relative to the vertical column through a lifting mechanism.

Optionally, the frame includes a fixing bracket fixed to an upper end of the upright, and the lifting mechanism connects the base bracket and the fixing bracket.

Optionally, the sample processing apparatus further includes a temperature detection device and a control unit, the temperature detection device is configured to detect a temperature of the sample in the needle tube, the temperature detection device and the heating device are both in communication connection with the control unit, and the control unit is capable of controlling the heating device to be turned on or turned off according to a temperature signal detected by the temperature detection device.

Optionally, the temperature detection device is configured as a non-contact temperature sensor, and the non-contact temperature sensor is arranged on the rack.

Optionally, the sample processing device further comprises a sample container removably placed below the needle tube connected to the housing, the extension and retraction of the plunger rod being driven by the plunger rod driver to transfer a sample between the needle tube and the sample container,

the piston rod driver is in communication connection with the control unit, and the control unit can control the piston rod driver to drive the piston rod to move, and can control the piston rod driver to drive the piston rod to realize at least one moving cycle after the heating device is started, wherein the piston rod retracts firstly and extends secondly in each moving cycle, so that the sample is firstly discharged from the needle tube into the sample container and then sucked back from the sample container into the needle tube.

Optionally, the number of the syringes is multiple, the syringes are arranged side by side at intervals along the Y direction of the sample processing device, the heat radiation source is configured as a lamp tube, the axis of the lamp tube is arranged to be approximately parallel to the Y direction, and the lamp tube extends to at least the outermost syringe at both ends of the Y direction.

Optionally, the heating device includes a lamp housing in which the lamp tube is accommodated and supported, and a side of the lamp housing facing the needle tube connected to the housing has a linear opening extending substantially in the Y direction, and a width of the linear opening defines a size of the thermal radiation heating area.

Optionally, the lamp tube is an infrared heating tube.

Through the technical scheme, in the process of processing the sample by using the sample processing equipment provided by the disclosure, the sample in the needle tube of the to-be-heated area can be heated by the heat radiation source in the non-contact heating device, the mode of heating the sample by the heat radiation can be immediately used for heating the sample after the heating device is opened, the time required by the temperature rise of the heating device is not needed, and the time required by heat exchange is also not needed, so that the heating efficiency and the operation efficiency of the sample can be effectively improved. In addition, the total energy radiated by the heat radiation source can be controlled to control the rising amplitude of the temperature of the sample, so that the accuracy of the analysis result of the sample can be improved. In addition, the extension and retraction of the piston rod in the shell can realize the circulation of the sample in the needle tube in the whole treatment process on one hand, and on the other hand, in the heating process, the throughput of the sample can be realized through the repeated movement of the extension and retraction of the piston rod in the shell, which is equivalent to the stirring of the sample, so that the temperature of the liquid in the needle tube is homogenized.

Additional features and advantages of the disclosure will be set forth in the detailed description which follows.

Drawings

The accompanying drawings, which are included to provide a further understanding of the disclosure and are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure without limiting the disclosure. In the drawings:

FIG. 1 is a schematic perspective view from the front to the back of a sample processing device provided in accordance with an embodiment of the present disclosure;

FIG. 2 is a schematic perspective view from the rear to the front of a sample processing device provided in accordance with an embodiment of the present disclosure, showing a slide rail and a tray;

FIG. 3 is a schematic perspective view from a rear to a front of another angle of a sample processing device provided in accordance with an embodiment of the present disclosure with the attachment bracket removed;

FIG. 4 is a front view of a sample processing device provided in accordance with an embodiment of the present disclosure;

FIG. 5 is a rear view of a sample processing device provided in accordance with an embodiment of the present disclosure;

FIG. 6 is a block diagram of a syringe and syringe in a ready-to-connect state in a sample processing device according to an embodiment of the present disclosure;

FIG. 7 is a schematic perspective view of a heating device in a sample processing apparatus according to an embodiment of the present disclosure;

fig. 8 is a schematic structural view of a swing arm, a roller, and a drive motor in a sample processing device according to an embodiment of the present disclosure.

Description of the reference numerals

1-a rack, 11-a basic bracket, 12-a column, 13-a fixed bracket, 14-a mounting bracket, 15-a sliding rail, 16-a tray, 2-an injector, 21-a shell, 22-a piston rod, 3-a needle tube, 4-a heating device, 41-a lamp tube, 42-a lamp shade, 421-a linear opening, 43-the lamp shade bracket, 5-a position adjusting mechanism, 51-a driving motor, 511-an output shaft, 52-a transmission structure, 521-a rocker arm, 522-a roller, 523-a connecting bracket, 5231-a long hole, 6-a guide mechanism, 61-a guide rail, 62-a sliding bracket, 7-a lifting mechanism, 8-a sample container and 9-a piston rod driver.

Detailed Description

The following detailed description of specific embodiments of the present disclosure is provided in connection with the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present disclosure, are given by way of illustration and explanation only, not limitation.

In the present disclosure, for convenience of understanding, the sample processing device is defined to have an X direction, a Y direction and a Z direction which are perpendicular to each other, wherein the X direction is a longitudinal direction of the sample processing device, a corresponding length is defined, front and rear positions are defined, the Y direction is a lateral direction of the sample processing device, a corresponding width is defined, left and right positions are defined, the Z direction is a vertical direction of the sample processing device, a corresponding height is defined, upper and lower positions are defined, specifically, a side on which the syringe 2 is located is front, a side on which the elevating mechanism 7 is located is rear, when the user faces forward, a side on which the left hand is located is a left position, a side on which the right hand is located is a right position, a side on which the head is located is up, and a side on which the foot is located is down, corresponding to the drawings, in fig. 1 to 3, an arrow in the X direction indicates a front position, an arrow in the Z direction indicates an up position, wherein an arrow in the Y direction indicates a left direction in fig. 1, and in fig. 2 and 3, an arrow in the Y direction indicates a right direction. In addition, unless otherwise stated, "inner and outer" are inner and outer with respect to the profile of the corresponding component itself. Furthermore, in the following description, when referring to the figures, the same reference numbers in different figures denote the same or similar elements, unless otherwise explained. The foregoing definitions are provided to illustrate and describe the present disclosure only and should not be construed to limit the present disclosure.

According to a specific embodiment provided by the present disclosure, there is provided a sample processing device, as shown with reference to fig. 1 to 3 and 6, including: a frame 1; a syringe 2 including a tubular housing 21 and a plunger rod 22, the plunger rod 22 having opposite operating and plunger ends, the housing 21 being disposed to the chassis 1 and having opposite first and second ends, the plunger end protruding into the housing 21 from the first end, the plunger rod 22 being movable relative to the housing 21 to extend and retract, the needle tube 3 being detachably and airtightly connected to the second end to draw a sample into the needle tube 3 by the extension of the plunger rod 22 and to discharge the sample from the needle tube 3 by the retraction of the plunger rod 22; a heating device 4, the heating device 4 being a non-contact heating device, the heating device 4 being disposed on the rack 1 and including a thermal radiation source defining a thermal radiation heating region, at least a portion of the needle tube 3 attached to the housing 21 defining a region to be heated of the sample, the region to be heated being located within the thermal radiation heating region.

Through the technical scheme, in the process of processing the sample by using the sample processing equipment provided by the disclosure, the sample in the needle tube 3 of the to-be-heated area can be heated by the heat radiation source in the non-contact heating device, the mode of heating the sample by the heat radiation can be immediately used for heating the sample after the heating device 4 is opened, the time required by the temperature rise of the heating device 4 is not needed, and the time required by heat exchange is also not needed, so that the heating efficiency and the operation efficiency of the sample can be effectively improved. In addition, the total energy radiated by the heat radiation source can be controlled to control the rising amplitude of the temperature of the sample, so that the accuracy of the analysis result of the sample can be improved. In addition, the extension and retraction of the plunger rod 22 in the housing 21 can realize the circulation of the sample in the syringe 3 in the whole treatment process on one hand, and can realize the throughput of the sample through the repeated extension and retraction of the plunger rod 22 in the housing 21 in the heating process on the other hand, which is equivalent to the stirring of the sample, thereby homogenizing the temperature of the liquid in the syringe 3.

In the specific embodiment provided by the present disclosure, referring to fig. 1, 5 and 6, the rack 1 may include a basic bracket 11, the housing 21 may be fixed on the front surface of the basic bracket 11 (i.e. the front side surface of the basic bracket 11), and the heating device 4 may be movably connected to the basic bracket 11, so that the heating device 4 can adjust the position relative to the basic bracket 11, so that the thermal radiation heating area covers the area to be heated, and the area to be heated is sufficiently heated, thereby ensuring the heating effect of the sample in the needle tube 3 of the area to be heated. Here, the present disclosure does not set any limitation to the manner of adjusting the position of the heating device 4 with respect to the base bracket 11, for example, the position of the heating device 4 with respect to the base bracket 11 may be adjusted manually or by a motor, and the present disclosure may be adaptively designed as needed.

In the embodiments provided by the present disclosure, the axis of the syringe 2 extends substantially along the Z-direction of the sample processing device, i.e. the axis of the syringe 3 detachably and sealingly connected to the syringe 2 also extends substantially along the Z-direction of the sample processing device, which is substantially parallel to the direction of gravity when the sample processing device is in use, so as to facilitate the control of the level of the liquid sample. The sample processing device comprises a position adjusting mechanism 5, and the position adjusting mechanism 5 drives the heating device 4 to move in the Z direction relative to the basic bracket 11, namely, the position of the heating device 4 relative to the basic bracket 11 is adjusted through a motorized adjustment mode, so that the working efficiency of the sample processing device is improved.

It should be noted here that the term "substantially" as used in the present disclosure is intended to mean a non-strict limitation, for example, "the axis of the syringe 2 extends substantially in the Z-direction of the sample processing device" may be understood as: due to objective factors such as manufacturing errors and mounting errors, the axis of the syringe 2 may be at a small angle, e.g., 0 ° to 5 °, to the Z-direction of the sample processing device, within which the axis of the syringe 2 is still considered parallel to the Z-direction of the sample processing device. The term "substantially" is used to allow a range of offsets to accommodate objective factors such as manufacturing tolerances and installation tolerances.

In the specific embodiments provided by the present disclosure, the position adjustment mechanism 5 may be configured in any suitable manner. Alternatively, as shown in fig. 2 to 4 and 8, the position adjusting mechanism 5 may include a driving motor 51 and a transmission structure 52, the driving motor 51 is fixed to the base bracket 11, and the heating device 4 is connected to the output of the driving motor 51 through the transmission structure 52, i.e., the transmission structure 52 is connected to the output of the driving motor 51 under the driving of the driving motor 51, so as to adjust the position of the heating device 4. In other embodiments of the present disclosure, the position adjusting mechanism 5 may also be configured in other configurations, for example, the position adjusting mechanism 5 is configured as a hydraulic transmission assembly and a fixing structure connected with each other, wherein the hydraulic transmission assembly is fixed on the base bracket 11, the fixing structure is connected with the heating device 4, and the heating device 4 is connected to the hydraulic transmission assembly through the fixing structure, so as to adjust the position of the heating device 4. The disclosure is not limited in this regard.

Wherein, referring to fig. 8, the output of the driving motor 51 may be configured as an output shaft 511, and the transmission structure 52 may be configured as a motion conversion structure, so that the rotation motion of the output shaft 511 can be converted into a linear motion of the heating device 4 in the Z direction under the driving of the driving motor 51, that is, the heating device 4 can move along the Z direction of the sample processing apparatus under the driving of the driving motor 51, so that the position of the heating device 4 relative to the basic rack 11 can be adjusted. In other embodiments of the present disclosure, the driving motor 51 may be configured as a non-output rotating shaft such as a push rod motor or a linear motor.

In the specific embodiments provided by the present disclosure, the transmission structure 52 may be configured in any suitable manner. Alternatively, as shown in fig. 2 to 4 and 8, the transmission structure 52 may include a swing arm 521, a roller 522, and a connecting bracket 523, the swing arm 521 having opposite start and end ends, the start end of the swing arm 521 being fixed to the output shaft 511 of the driving motor 51, the roller 522 being pivotally disposed at the end of the swing arm 521, that is, the swing arm 521 for connecting the output shaft 511 of the driving motor 51 and the roller 522 so that the output shaft 511 of the driving motor 51 can transmit power to the roller 522 through the swing arm 521, an extending direction of the swing arm 521 from the start end to the end being substantially perpendicular to an axis of the output shaft 511, the connecting bracket 523 extending substantially in a Y direction of the sample processing apparatus and being provided with a long hole 5231 extending substantially in the Y direction, the roller 522 being fitted in the long hole 5231 and being movable in the Y direction in the long hole 5231, the heating device 4 being fixed relative to the connecting bracket 523. Under the driving of the driving motor 51, the output shaft 511 of the driving motor 51 rotates and drives the rocker arm 521 to rotate around the axis of the output shaft 511, so that the roller 522 connected with the rocker arm 521 moves in the Y direction in the long hole 5231 of the connecting bracket 523, and during the movement of the roller 522, as the rocker arm 521 rotates around the axis of the output shaft 511, the roller 522 applies an upward or downward force to the connecting bracket 523, so that the connecting bracket 523 moves upward or downward in the Z direction. For example, when the swing arm 521 rotates clockwise, the roller 522 applies an upward force to the link bracket 523, thereby moving the link bracket 523 upward in the Z-direction, and when the swing arm 521 rotates counterclockwise, the roller 522 applies a downward force to the link bracket 523, thereby moving the link bracket 523 downward in the Z-direction. And the connecting bracket 523 is fixedly connected with the heating device 4, so that the heating device 4 is driven to move along the Z direction in the moving process of the connecting bracket 523, and the position of the heating device 4 is adjusted. In other embodiments of the present disclosure, the transmission structure 52 may also have other configurations, for example, the transmission structure 52 is configured as a screw transmission structure, a rack and pinion transmission structure, or the like. The disclosure is not intended to be limited in any way.

It should be noted that the term "substantially" used in the present disclosure is intended to mean a non-strict limitation, and for example, "the direction in which the swing arm 521 extends from the beginning to the end is substantially perpendicular to the axis of the output shaft 511" may be understood as: due to objective factors such as manufacturing errors and mounting errors, the extending direction of the rocker arm 521 from the start end to the end may have a certain small angle with the direction perpendicular to the axis of the output shaft 511, for example, 0 ° to 5 °, and within this range, the extending direction of the rocker arm 521 from the start end to the end is still considered to be parallel to the direction perpendicular to the axis of the output shaft 511, that is, the extending direction of the rocker arm 521 from the start end to the end is perpendicular to the axis of the output shaft 511. The term "substantially" is used in an attempt to allow a range of offsets to accommodate objective factors such as manufacturing tolerances and installation tolerances.

In the specific embodiment provided by the present disclosure, the sample processing apparatus may further include a guide mechanism 6 to ensure the moving track of the heating device 4. Wherein the guiding mechanism 6 may be configured in any suitable way. Alternatively, referring to fig. 2 to 4, the guide mechanism 6 includes a Z-guide rail 61 disposed on the back of the base bracket 11 and a sliding bracket 62 engaged with the guide rail 61 and capable of sliding along the guide rail 61, the sliding bracket 62 is connected to the connecting bracket 523, that is, when the connecting bracket 523 is driven by the driving motor 51 to move, since the connecting bracket 523 is connected to the sliding bracket 62 and the sliding bracket 62 can move on the guide rail 61, the connecting bracket 523 drives the sliding bracket 62 to move along the guide rail 61, that is, the moving track of the connecting bracket 523 along the Z direction is limited by the guide rail 61 and the sliding bracket 62. In other embodiments of the present disclosure, the guiding mechanism 6 may also be in other configurations, and the present disclosure is not limited in any way.

Wherein, guiding mechanism 6 can be provided with two sets ofly, two sets of guiding mechanism 6 set up to the interval along Y, and connect through linking bridge 523 between the support 62 that slides in two sets of guiding mechanism 6, heating device 4 connects the lower extreme at two support 62 that slide, linking bridge 523 can drive the support 62 that slide of both sides when moving along Z, such mode of setting up can make two sets of guiding mechanism 6 can calibrate the guide direction each other on the one hand, on the other hand, still can provide both ends for connecting two heating device 4 at two support 62's that slide lower extreme and support, thereby improve heating device 4's installation stability and reliability.

In the specific embodiment provided by the present disclosure, the sample processing apparatus may further include a position detection device and a control unit, the position detection device is configured to detect a position of the heating device 4 in the Z direction relative to the basic support 11, the position detection device and the position adjusting mechanism 5 are both in communication connection with the control unit, the control unit controls the position adjusting mechanism 5 to drive the heating device 4 to move to enable the thermal radiation heating region to cover the region to be heated according to a position signal detected by the position detection device, wherein the control unit may control a rotation angle of the output shaft 511 of the driving motor 51 according to the position signal detected by the position detection device to control a movement range of the heating device 4 in the Z direction, and the position of the heating device 4 may be automatically adjusted without manual operation, so that the thermal radiation heating region may be always covered in the region to be heated, thereby being beneficial to realize automation of the sample processing apparatus.

In the specific embodiment provided by the present disclosure, referring to fig. 4, the rack 1 may include an upright 12 extending along the Z direction, the lifting mechanism 7 is further provided on the rack 1, and the base support 11 can be driven by the lifting mechanism 7 to move up and down along the Z direction relative to the upright 12, wherein the arrangement space and the operation space of each device and structure of the sample processing apparatus can be provided by the arrangement of the upright 12, thereby making the structure of the sample processing apparatus more compact.

In the embodiment provided by the present disclosure, the rack 1 may include a fixing bracket 13 fixed at the upper end of the upright 12, and the lifting mechanism 7 connects the base bracket 11 and the fixing bracket 13, i.e. the base bracket 11 can be driven by the lifting mechanism 7 to move up and down in the Z direction relative to the fixing bracket 13, so as to control the syringe 2 to suck or discharge the sample from the syringe 3. The lifting mechanism 7 may be constructed in any suitable manner, for example, the lifting mechanism 7 may be constructed as a hydraulic cylinder, the cylinder body of which is connected to the base support 11, and the piston rod of which is connected to the fixing support 13, or vice versa. For example, the lifting mechanism 7 includes a motor and a screw transmission mechanism, the motor is fixed on the fixed bracket 13 and is used for driving the screw to rotate, the screw is matched with a nut, the nut is fixed on the basic bracket 11, and the nut drives the basic bracket 11 to move up and down through the rotation of the screw.

In the specific implementation manner provided by the present disclosure, the sample processing apparatus may further include a temperature detection device and a control unit, the temperature detection device is configured to detect a temperature of the sample in the needle tube 3, the temperature detection device and the heating device 4 are both in communication connection with the control unit, and the control unit can control the heating device 4 to be turned on and off according to a temperature signal detected by the temperature detection device, so as to timely turn on or turn off the heating device 4 to heat the sample in the region to be heated, thereby being beneficial to implementing automatic control of heating. In addition, the control unit can also control the heating temperature and the heating time of the heating device 4 according to the temperature signal detected by the temperature detection device, so that the sample processing device can be used for performing personalized heating processing on samples needing to be heated for a certain time, samples needing to be heated for different temperatures and samples needing to be heated for a certain time, and the application range of the sample processing equipment is wider.

In the specific embodiments provided by the present disclosure, the temperature detection device may be configured in any suitable manner. Alternatively, the temperature detecting means may be configured as a non-contact temperature sensor, which may be provided on the rack 1 via a mounting bracket 14, as shown in fig. 1, for detecting the temperature of the sample in the area to be heated. Compared with a contact temperature detection mode, the non-contact temperature detection mode can improve the effectiveness of a sample temperature detection result on one hand, and can reduce the limitations on the position and installation of the temperature detection device on the other hand. In other embodiments of the present disclosure, the temperature detecting device may also be configured in other manners, and the present disclosure is not limited thereto.

In the embodiment provided by the present disclosure, the sample processing apparatus may further include a sample container 8 and a plunger rod driver 9, the sample container 8 being removably placed below the needle tube 3 connected to the housing 21, and the plunger rod 22 being driven by the plunger rod driver 9 to extend and retract within the housing 21 for transferring the sample between the needle tube 3 and the sample container 8 so as to continuously heat-treat the sample, thereby improving the efficiency of the sample processing apparatus.

Wherein, the piston rod driver 9 is connected with the control unit in communication, the control unit can control the piston rod driver 9 to drive the movement of the piston rod 22, and can control the piston rod driver 9 to drive the piston rod 22 to realize at least one movement cycle after the heating device 4 is started, wherein, in each movement cycle, the piston rod 22 firstly retracts and then extends, so that the sample is firstly discharged into the sample container 8 from the needle tube 3 and then is sucked back into the needle tube 3 from the sample container 8, the piston rod driver 9 drives the piston rod 22 to reciprocate, so as to suck and spit the sample, which is equivalent to the stirring of the sample, and is beneficial to the homogenization of the temperature of the sample.

In the specific embodiments provided by the present disclosure, the syringe 2 may be arranged in any suitable manner. Alternatively, the number of the syringes 2 may be plural, a plurality of the syringes 2 are arranged side by side at intervals along the Y direction of the sample processing apparatus, and by arranging a plurality of the syringes 2 arranged side by side along the Y direction, the working efficiency of the sample processing apparatus can be improved by driving the piston rods 22 of the plurality of the syringes 2 at the same time. In this case, the above-mentioned plunger rod driver 9 may be shared, i.e., one plunger rod driver 9 is used to synchronously drive the movement of the plunger rods 22 in a plurality of syringes 2, so as to achieve efficient batch processing of samples, thereby being beneficial to improve the working efficiency of the sample processing apparatus. Further, the thermal radiation source in this case may be configured as a lamp tube 41, the lamp tube 41 being disposed with its own axis substantially parallel to the Y direction and extending at both ends in the Y direction at least to the outermost injector 2, so that the heat radiating home region defined by the lamp tube 41 can cover the region to be heated where the sample is located, thereby ensuring that the samples in the needle tubes 3 below the injectors 2 disposed side by side can each be subjected to the heat treatment. In other embodiments of the present disclosure, the injector 2 may be arranged in other ways, and the present disclosure is not limited thereto.

It should be noted that the term "substantially" used in the present disclosure is intended to mean a non-strict limitation, and for example, "the lamp 41 is disposed with its own axis substantially parallel to the Y direction" may be understood as: due to objective factors such as manufacturing errors and installation errors, the axis of the lamp 41 itself may have a certain small included angle with the Y direction, for example, 0 ° to 5 °, within this range, the axis of the lamp 41 itself is still considered to be parallel to the Y direction. The term "substantially" is used to allow a range of offsets to accommodate objective factors such as manufacturing tolerances and installation tolerances.

In the specific embodiments provided by the present disclosure, the heating device 4 may be configured in any suitable manner. Alternatively, referring to fig. 7, the heating device 4 includes a lamp housing 42, the lamp 41 is accommodated and supported in the lamp housing 42, one side of the lamp housing 42 facing the needle tube 3 connected to the casing 21 has a linear opening 421 extending in the Y direction, the width of the linear opening 421 defines the size of the thermal radiation heating area, and the linear opening 421 is configured to limit the heating of the sample by the lamp 41, i.e. to heat the sample in a targeted manner, which on one hand can avoid heat loss caused by excessive infrared radiation, and on the other hand, can effectively avoid the accelerated aging of the surrounding structure of the needle tube 3 after being heated by the thermal radiation, thereby prolonging the service life of the sample processing device. In addition, the lampshade 42 is provided with lampshade brackets 43 at two ends along the Y direction, so as to connect the sliding bracket 62 through the lampshade brackets 43, so that the sliding bracket 62 can drive the lampshade brackets 43 to move along the Z direction in the moving process along the Z direction, and further drive the whole heating device 4 to move along the Z direction. In other embodiments of the present disclosure, the heating device 4 may also be configured in other ways, and the present disclosure is not limited thereto.

It should be noted that the term "substantially" used in the present disclosure is intended to mean a non-strict limitation, for example, that "the lamp shade 42 has a linear opening 421 extending substantially in the Y direction on the side facing the needle cannula 3 connected to the housing 21" may be understood as: due to objective factors such as manufacturing errors and mounting errors, the linear opening 421 may have a certain small angle with the Y direction, for example, 0 ° to 5 °, within which the linear opening 421 is still considered to be parallel to the Y direction. The term "substantially" is used to allow a range of offsets to accommodate objective factors such as manufacturing tolerances and installation tolerances.

In the specific embodiments provided by the present disclosure, the light tubes 41 may be configured in any suitable manner. Alternatively, the lamp 41 is an infrared heating tube, wherein the infrared heating tube is a tubular heater using the infrared principle, which has high thermal efficiency, rapid temperature rise, and reliable energy saving. In other embodiments of the present disclosure, the lamp 41 may have other configurations, and the present disclosure is not limited thereto.

In summary, when the sample processing device provided by the present disclosure is used for sample processing, the needle tube 3 may be detachably and hermetically connected to the lower end of the syringe 2, the sample container 8 containing the sample is placed in the tray 16 on the rack 1, the tray 16 is in sliding fit with the slide rail 15 on the rack 1 to transport the sample to the lower part of the needle tube 3, and the lifting mechanism 7 drives the basic bracket 11 to move downwards along the Z direction relative to the upright 12, so that the lower end of the needle tube 3 can contact the sample in the sample container 8. The control unit then controls the piston rod driver 9 to drive the piston rod 22 upwards to aspirate the sample in the sample container 8. Then, the control unit controls the position adjusting mechanism 5 to drive the heating device 4 to move to a position where the thermal radiation heating region covers the region to be heated according to the position signal detected by the position detecting device, and controls the lamp 41 to be turned on so as to heat the sample in the needle tube 3 through the heat radiated by the lamp 41, when the sample is heated to a required temperature, the control unit can control the heating device 4 to be turned off according to the temperature signal detected by the temperature detecting device, so that the heating device 4 is timely turned off to heat the sample in the region to be heated, and the heating treatment of the samples in sequence is completed. After that, the lifting mechanism 7 can drive the basic frame 11 to move upward along the Z direction relative to the column 12, so that the needle tube 3 sucking the sample is moved to a proper position, thereby facilitating the subsequent processing operation.

The width of the linear opening 421 limits the size of the thermal radiation heating area, which not only can avoid heat loss caused by redundant infrared radiation, but also can effectively avoid the aging acceleration of the surrounding structure of the needle tube 3 after being heated by thermal radiation, thereby prolonging the service life of the sample processing equipment. In the sample processing equipment provided by the disclosure, the sample is heated in a non-contact temperature detection mode, so that the heating efficiency can be effectively improved, and the validity of a sample temperature detection result is ensured.

The preferred embodiments of the present disclosure are described in detail with reference to the accompanying drawings, however, the present disclosure is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical idea of the present disclosure, and these simple modifications all belong to the protection scope of the present disclosure.

It should be noted that the various features described in the foregoing embodiments may be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, various possible combinations will not be separately described in this disclosure.

In addition, any combination of various embodiments of the present disclosure may be made, and the same should be considered as the disclosure of the present disclosure, as long as it does not depart from the spirit of the present disclosure.

Claims

1. A sample processing device, characterized in that the sample processing device comprises:

a frame (1);

a syringe (2) comprising a tubular housing (21) and a plunger rod (22), the plunger rod (22) having opposite operating and plunger ends, the housing (21) being disposed in the chassis (1) and having opposite first and second ends, the plunger end protruding from the first end into the housing (21), the plunger rod (22) being movable relative to the housing (21) to extend and retract, a needle cannula (3) being detachably and hermetically connected to the second end to draw a sample into the needle cannula (3) by extension of the plunger rod (22) and to expel the sample from the needle cannula (3) by retraction of the plunger rod (22);

a heating device (4), the heating device (4) being a non-contact heating device, the heating device (4) being arranged at the gantry (1) and comprising a thermal radiation source defining a thermal radiation heating area, at least a portion of the needle tube (3) attached to the housing (21) defining a region of the sample to be heated, the region to be heated being located within the thermal radiation heating area,

the sample processing equipment further comprises a temperature detection device and a control unit, wherein the temperature detection device is used for detecting the temperature of the sample in the needle tube (3), the temperature detection device and the heating device (4) are in communication connection with the control unit, the control unit can control the heating device (4) to be turned on and off according to a temperature signal detected by the temperature detection device, the temperature detection device is constructed as a non-contact temperature sensor, and the non-contact temperature sensor is arranged on the rack (1).

2. The specimen-processing apparatus according to claim 1, characterized in that the gantry (1) comprises a basic support (11), the housing (21) being fixed to a front face of the basic support (11), the heating device (4) being movably connected to the basic support (11) so as to be adjustable in position with respect to the basic support (11) such that the thermal radiation heating area covers the area to be heated.

3. The sample processing device according to claim 2, characterized in that the axis of the injector (2) extends substantially in the Z-direction of the sample processing device, the sample processing device comprising a position adjustment mechanism (5), the position adjustment mechanism (5) driving the movement of the heating means (4) in the Z-direction relative to the base support (11).

4. The sample processing device according to claim 3, wherein the position adjustment mechanism (5) comprises a drive motor (51) and a transmission structure (52), the drive motor (51) being fixed to the base support (11), the heating means (4) being connected to an output of the drive motor (51) through the transmission structure (52).

5. The sample processing apparatus according to claim 4, wherein the output of the drive motor (51) is configured as an output shaft (511) and the transmission structure (52) is configured as a motion converting structure to convert the rotational motion of the output shaft (511) into a linear motion of the heating device (4) in the Z-direction.

6. The sample processing device according to claim 5, wherein the transmission structure (52) comprises a rocker (521), a roller (522) and a connecting bracket (523), the rocker (521) having opposite starting and ending ends, the starting end being fixed to the output shaft (511), the roller (522) being pivotally arranged at the ending end, the direction of extension of the rocker (521) from the starting end to the ending end being substantially perpendicular to the axis of the output shaft (511), the connecting bracket (523) extending substantially in the Y-direction of the sample processing device and being provided with an elongated hole (5231) extending substantially in the Y-direction, the roller (522) being fitted in the elongated hole (5231) and being movable in the Y-direction in the elongated hole (5231), the heating means (4) being fixed relative to the connecting bracket (523).

7. The sample processing device according to claim 6, further comprising a guide mechanism (6), wherein the guide mechanism (6) comprises a Z-directional guide rail (61) disposed on the back surface of the base frame (11) and a sliding frame (62) fitted on the guide rail (61) and slidable along the guide rail (61), and the sliding frame (62) is connected to the connecting frame (523).

8. The sample processing apparatus according to claim 7, wherein the guide mechanisms (6) are provided in two sets, the two sets of guide mechanisms (6) are arranged at intervals along the Y direction, the sliding brackets (62) in the two sets of guide mechanisms (6) are connected through the connecting bracket (523), and the heating device (4) is connected to the lower ends of the two sliding brackets (62).

9. The specimen-processing apparatus according to claim 3, characterized in that it further comprises a position detection device for detecting the position of the heating device (4) in the Z direction relative to the base support (11), and a control unit, both the position detection device and the position adjustment mechanism (5) being in communication connection with the control unit, the control unit controlling the position adjustment mechanism (5) to drive the heating device (4) to move such that the thermal radiation heating area covers the area to be heated according to a position signal detected by the position detection device.

10. The sample processing device according to claim 2, characterized in that the rack (1) comprises a column (12) extending in the Z-direction, the base support (11) being drivable in the Z-direction up and down with respect to the column (12) by means of a lifting mechanism (7).

11. The sample processing device according to claim 10, wherein the frame (1) comprises a fixed bracket (13) fixed to an upper end of the upright (12), the lifting mechanism (7) connecting the base bracket (11) and the fixed bracket (13).

12. The sample processing device according to claim 1, further comprising a sample container (8) and a plunger rod driver (9), the sample container (8) being removably placed below the needle (3) connected to the housing (21), the extension and retraction of the plunger rod (22) being driven by the plunger rod driver (9) to transfer a sample between the needle (3) and the sample container (8),

the piston rod driver (9) is in communication connection with the control unit, and the control unit can control the piston rod driver (9) to drive the piston rod (22) to move, and can control the piston rod driver (9) to drive the piston rod (22) to realize at least one moving period after the heating device (4) is started, wherein the piston rod (22) firstly retracts and then extends in each moving period, so that the sample is firstly discharged from the needle tube (3) into the sample container (8) and then sucked back from the sample container (8) into the needle tube (3).

13. The sample processing device according to any one of claims 1 to 12, wherein the number of the syringes (2) is plural, a plurality of the syringes (2) are arranged side by side at intervals along a Y-direction of the sample processing device, and the thermal radiation source is configured as a lamp (41), and the lamp (41) is arranged such that its own axis is substantially parallel to the Y-direction and extends at both ends of the Y-direction at least to the outermost syringe (2).

14. The specimen-processing apparatus according to claim 13, characterized in that the heating device (4) comprises a lamp housing (42), the lamp vessel (41) being accommodated and supported in the lamp housing (42), the side of the lamp housing (42) facing the needle tube (3) connected to the housing (21) having a linear opening (421) extending substantially in the Y-direction, the width of the linear opening (421) defining the size of the thermal radiation heating area.

15. The sample processing apparatus of claim 13, wherein the light tube (41) is an infrared heating tube.