WO2021134610A1

WO2021134610A1 - Sample analysis device and sample analysis method

Info

Publication number: WO2021134610A1
Application number: PCT/CN2019/130803
Authority: WO
Inventors: 李鑫; 闫华文; 吕富尧; 柴亮; 李爱博
Original assignee: 深圳迈瑞生物医疗电子股份有限公司; 北京深迈瑞医疗电子技术研究院有限公司
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2021-07-08
Also published as: CN114008460A

Abstract

A sample analysis device and a sample analysis method. The sample analysis device has one or more reagent dispensing components (60), wherein the number of reagent dispensing components (60) is equal to the number of processing units (50); each reagent dispensing component (60) comprises: a plurality of reagent needles (61), a guide assembly (62) used for guiding the plurality of reagent needles (61) to move linearly, and a second driving assembly (63) that drives the plurality of reagent needles (61) to move linearly along the guide assembly (62); and the guide assembly (62) is arranged along the direction determined by a reagent suction position and a reagent-adding transfer position of a processing unit (50) corresponding to a reagent dispensing component (60), so that the reagent needles (61) suck a reagent from the reagent suction position and discharge same into a reaction cup at the reagent-adding transfer position of the processing unit (50) corresponding to the reagent dispensing component (60).

Description

Sample analysis device and sample analysis method

Technical field

The invention relates to a sample analysis device and a sample analysis method.

Background technique

Sample analysis devices, such as biochemical analyzers, immunoassay analyzers, coagulation analyzers, and cell analyzers, are instruments used to analyze and determine samples. Generally, reagents are added to the sample to pass the sample after reacting with the reagent. A certain way to measure the characteristics, chemical composition and concentration of the sample itself.

The improvement of the test speed of the sample analysis device is the goal pursued by the technicians; the miniaturization of the sample analysis device is also one of the goals pursued by the technicians; in order to increase the test speed of the sample analysis device, one idea is to increase the relevant components, such as Multiple injection needles, etc., but the addition of related components will increase the volume of the instrument, which goes against the goal of miniaturization of the instrument pursued by the technicians. Therefore, how to resolve or balance the contradiction between speed-up and miniaturization of the sample analysis device is the goal of the present invention.

Summary of the invention

technical problem

The present invention mainly provides a sample analysis device and a sample analysis method, which will be described in detail below.

The solution to the problem

Technical solutions

According to the first aspect, a sample analysis device includes:

chassis;

The reaction cup loading parts are used to supply and carry empty reaction cups;

Sampling component, used to dispatch the sample rack carrying the sample to the sample suction position;

The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;

A reagent carrying part, which is arranged in a disc-shaped structure, has a plurality of positions for carrying the first reagent container of the first reagent, and has a plurality of positions for carrying the second reagent container of the second reagent Position; the reagent carrying member includes a first driving assembly for driving its rotation, the first driving assembly drives the reagent carrying member to rotate and drives the first reagent container to rotate, so as to rotate the first reagent container to the first Reagent suction position; the first drive assembly drives the reagent carrying member to rotate and drives the second reagent container to rotate, so as to rotate the second reagent container to the second reagent suction position;

The reaction part is used to carry the reaction cup and incubate the sample in the reaction cup, and the reaction part is configured with at least one position for placing the reaction cup during incubation;

The measuring component is used to carry the reaction cup and detect the sample in the reaction cup, and the measuring component is configured with at least one mid-measurement index for placing the position of the reaction cup;

The first reagent dispensing component includes: a first beam and a first group of reagent needles, the first group of reagent needles includes at least a plurality of first reagent needles; the plurality of first reagent needles are arranged on the first beam, And move linearly along the long axis of the first beam, so as to suck the first reagent from the first reagent suction position and discharge it into the reaction cup positioned in the incubation;

The second reagent dispensing component includes: a second beam and a second group of reagent needles, the second group of reagent needles includes at least a plurality of second reagent needles; the plurality of second reagent needles are arranged on the second beam, And move linearly along the long axis direction of the second beam to suck the second reagent from the second reagent suction position and discharge it into the reaction cup that is positioned in the middle of the measurement;

The scheduling component is used to schedule the reaction cups; the scheduling component schedules the reaction cup with the first reagent added on the index during the incubation to the reaction part, and schedules the reaction cup with the second reagent added on the index during the measurement to the measurement part.

According to a second aspect, an embodiment provides a sample analysis device, including:

The reagent carrying part is used to rotate the reagent carrying part, and is used to rotate the reagent container to the reagent suction position;

One or more processing units; the processing unit is used to receive a reaction cup carrying a sample and process the sample in the reaction cup; wherein each processing unit is configured with a corresponding reagent addition intermediate transposition;

One or more reagent dispensing components, the number of reagent dispensing components is equal to the number of processing units, and one reagent dispensing component corresponds to a processing unit; each reagent dispensing component includes: multiple reagent needles, A guide assembly that guides a plurality of the reagent needles for linear movement, and a second drive assembly that drives a plurality of reagent needles to move linearly along the guide assembly; the guide assembly is along the reagent suction position and the corresponding reagent dispensing part The direction determined by the transposition in the reagent addition of the processing unit is set, so that the reagent needle sucks the reagent from the reagent suction position and discharges it into the reagent-adding reaction cup of the processing unit corresponding to the reagent dispensing component; and

The scheduling component is used to schedule the reaction cups located in the sample loading position to complete the sample addition to each processing unit according to the detection flow.

According to the third aspect, an embodiment provides a sample analysis method, including the following steps:

Reaction cup loading step, controlling the supply of reaction cup loading parts and carrying empty reaction cups;

In the sample feeding step, the sample feeding component is controlled to dispatch the sample rack carrying the sample to the sample suction position;

In the sample dispensing step, control the sample dispensing component to aspirate the sample from the sample suction position and dispense it into the reaction cup;

In the first reagent dispensing step, the driving part is controlled to drive the reagent carrying part to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position; at least one of the two reagent needles on the first reagent dispensing part is controlled The first reagent in the reagent container is sucked through the first reagent sucking position, and a linear movement is made between the first reagent sucking position and the indexing of the reagent adding of the reaction part to index the reagents of the reaction part Dispense the first reagent into the reaction cup;

In the incubation step, the control scheduling component schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measurement component for transposition;

In the second reagent dispensing step, the reagent carrying part is controlled to rotate so that the reagent container carrying the second reagent is located at the second reagent suction position; at least one of the two reagent needles on the second reagent dispensing part is controlled to pass through the The second reagent sucking position sucks the second reagent in the reagent container, and moves linearly between the second reagent sucking position and the indexing of the reagent adding of the measuring part to transfer the reaction cup into the reagent adding of the measuring part Dispense the second reagent;

In the measurement and recovery step, the control and scheduling component dispatches the reaction cup that has completed the dispensing of the second reagent to the measurement component for item detection, and dispatches the reaction cup after the detection to the waste recovery device.

The beneficial effects of the invention

Brief description of the drawings

Description of the drawings

FIG. 1 is a schematic structural diagram of a sample analysis device according to an embodiment;

FIG. 2 is a schematic structural diagram of a sample analysis device of another embodiment;

FIG. 3 is a schematic structural diagram of a sample analysis device according to another embodiment;

4(a) and 4(b) are schematic diagrams of the structure of the reagent carrying member of two embodiments;

FIG. 5 is a schematic diagram of the structure of a reagent carrying member according to another embodiment;

FIG. 6 is a schematic structural diagram of a sample analysis device according to another embodiment;

FIG. 7 is a schematic structural diagram of a reagent dispensing component of an embodiment;

Fig. 8 is a schematic structural diagram of a reagent dispensing component of another embodiment;

FIG. 9 is a schematic structural diagram of a reagent dispensing component according to another embodiment;

Fig. 10 is a schematic diagram of the structure of a reagent dispensing component according to another embodiment.

FIG. 11 is a schematic structural diagram of a sample analysis device according to another embodiment;

Figure 12 (a) is a schematic structural diagram of a transport component of an embodiment, Figure 12 (b) is a schematic structural diagram of a first transport component of an embodiment, and Figure 12 (c) is a second transport component of an embodiment Schematic diagram of the structure of the component, FIG. 12(d) is a schematic diagram of the structure of the third transport component of an embodiment;

Figure 13 is a schematic structural diagram of an embodiment of a cup grasping hand;

FIG. 14 is a schematic structural diagram of a sample analysis device according to still another embodiment;

FIG. 15 is a schematic structural diagram of a sample analysis device according to still another embodiment;

Figure 16 is a schematic structural diagram of a cleaning component of an embodiment;

FIG. 17 is a schematic flowchart of a sample analysis method according to an embodiment;

18 is a time sequence diagram of two reagent needles in the same group according to an embodiment;

FIG. 19 is a time sequence diagram of two reagent needles in the same group according to another embodiment;

FIG. 20 is a time sequence diagram of two reagent needles in the same group according to another embodiment;

FIG. 21 is a time sequence diagram of two reagent needles in the same group according to another embodiment;

Fig. 22 shows a method of a sample analysis device according to an embodiment.

Invention embodiment

Embodiments of the present invention

Hereinafter, the present invention will be further described in detail through specific embodiments in conjunction with the accompanying drawings. Among them, similar elements in different embodiments use related similar element numbers. In the following embodiments, many detailed descriptions are used to enable the present invention to be better understood. However, those skilled in the art can easily realize that some of the features can be omitted under different circumstances, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the present invention are not shown or described in the specification. This is to prevent the core part of the present invention from being overwhelmed by excessive descriptions. For those skilled in the art, these are described in detail. Related operations are not necessary, they can fully understand the related operations based on the description in the manual and the general technical knowledge in the field.

In addition, the features, operations, or features described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be sequentially exchanged or adjusted in a manner obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for clearly describing a certain embodiment, and are not meant to be a necessary sequence, unless a certain sequence is required to be followed unless otherwise stated.

The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the described objects and do not have any sequence or technical meaning. The terms "connection" and "connection" in the present invention include direct and indirect connection (connection) unless otherwise specified.

The structure of the sample analysis device according to some embodiments of the present invention will be described below.

The sample analysis device is an instrument used to analyze and measure samples. Take the coagulation analyzer as an example to illustrate the test process of the sample analysis device. The test procedure of a blood coagulation analyzer is generally as follows: complete sample addition and reagent addition into the reaction cup to prepare a reaction solution, and after mixing and incubating the reaction solution, the reaction cup is placed in the measurement part. The measuring part can irradiate the reaction liquid in the cuvette with multi-wavelength light, and analyze it by coagulation method, immunoturbidimetric method, or chromogenic substrate method to obtain the coagulation reaction curve of the reaction liquid over time, so as to further calculate The clotting time of the reaction solution or other clotting-related performance parameters. Since the coagulation analyzer is used to obtain the coagulation reaction curve of the reaction solution over time, in order to obtain the correct measurement result, the time boundary conditions such as the addition time of the sample and the reagent and the incubation time must be strictly set in the test process. Set and control.

Please refer to FIG. 1, which is a schematic structural diagram of a sample analysis device according to some embodiments of the present invention. The sample analysis device of some embodiments of the present invention may include a casing 1, a cuvette loading part 10, a sample part 20, a sample dispensing part 30, a reagent carrying part 40, one or more reagent dispensing parts 60, one or more The processing unit 50 and the scheduling component 70. It should be noted that the example shown in FIG. 1 is an example with two reagent dispensing parts 60 and two processing units 50, but those skilled in the art will understand that this is only for example, and is not used to limit the reagents. The number of the dispensing part 60 and the processing unit 50 can only be two. The following is a detailed description of each component in the sample analysis device.

The casing 1 is the instrument housing of the sample analysis device. For example, it may have a box shape that is basically a cuboid or a cube, and its function may be to accommodate some parts of the sample analysis device. For example, in some embodiments, the casing 1 includes a first side 1a along the first direction and a second side 1b along the second direction.

The first direction and the second direction referred to herein, in some embodiments, the two directions, that is, the first direction and the second direction, may be perpendicular, for example, the first direction is the Y direction in the figure, and the second direction is the The X direction.

The cuvette loading part 10 is used for supplying and carrying empty cuvettes. In the working process of the sample analysis device, it is necessary to continuously use the empty reaction cup to complete each test item. The sample analysis device adds samples and reagents to the empty reaction cup to prepare, incubate and measure the reaction solution to obtain the project’s results. Test Results. The cuvette loading part 10 can load an empty cuvette to a predetermined position, and the sample dispensing mechanism sucks a sample from the sample part 20 and discharges it into the empty cuvette at the predetermined position.

The sample part 20 is used to supply a sample rack carrying a sample to be tested. In some embodiments, the sample component 20 may be arranged in the casing 1. The sample part 20 can be implemented in multiple ways.

In an implementation manner of the sample component 20, the sample component 20 may be a sample injection component 21, and the sample injection component 21 is used to schedule the sample rack carrying the sample to the sample suction position. Fig. 2 is an example. The sampling component 21 may include a loading area 21a, a sampling channel 21b, and an unloading area 21c, wherein the sampling channel 21b may be provided with a sample suction position 21d. In the figure, the X direction and the Y direction are perpendicular, the X1 direction and the X2 direction are opposite directions, and the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a. The loading area 21a moves the sample rack to the Y1 direction in the figure to enter the sampling channel 21b. The sample rack can move along the X1 direction in the sampling channel 21b and pass through the suction. Sample position, the sample on the sample rack can be sucked by the sample dispensing part 30 when passing the sample aspiration position. After the sample rack enters the unloading area 21c from the sampling channel 21b along the Y2 direction, the user can take it out of the unloading area 21c Sample rack. The sample injection component 21 is more suitable for large-scale sample testing occasions, and the sample injection component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to the test system in the form of an assembly line, the sample injection component 21 can be directly connected. tear down.

In another implementation of the sample component 20, the sample component 20 may be a sample placement area 22, and the sample placement area 22 is used to place a sample rack carrying a sample to be tested. Figure 3 is an example. The sample placement area 22 can have multiple channels 22a, and each channel 22a can place a sample rack. The user can push the sample rack into the channel 22a along the Y1 direction in the figure; the sample dispensing component 30 can suck the sample racks in each channel 22a in turn After the samples on the sample rack are all sucked, the user can pull the sample rack out of the channel 22a along the Y2 direction in the figure. The sample placement area 22 does not require scheduling of the sample rack, so it occupies a small volume, which is beneficial to reduce the size of the sample analysis device, and is very beneficial to the miniaturized design of the sample analysis device.

The sample dispensing component 30 is used for aspirating samples from the sample suction position and discharging them into the reaction cup located at the sample adding position. In some embodiments, the sample dispensing component 30 may be arranged in the casing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, there may be one or more sample needles. In order to simplify the movement trajectory and reduce the volume and size of the sample analysis device, the sample suction position and the predetermined position where the cuvette loading part 10 loads the empty cuvette can be designed to be on a straight line, such as a straight line along the first direction. In this way, the sample needle only needs to reciprocate between the sample suction position and the above-mentioned predetermined position in the first direction, which not only improves the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very important for the miniaturization design of the sample analysis device. favorable.

The reagent carrying component 40 is used to carry reagents. For example, the reagent carrying component 40 may have multiple positions for carrying reagent containers, and the reagent containers are used to carry reagents. Generally, the reagent carrying member 40 can provide functions such as refrigeration for the carried reagent, so as to ensure the activity of the reagent. In some embodiments, the reagent carrying member 40 may be disposed in the casing 1. In some embodiments, the reagent carrying member 40 is arranged in a disk-shaped structure, which has a plurality of positions for carrying reagent containers, and the reagent carrying member 40 can rotate and drive the reagent container carried by it to transfer, thereby rotating the reagent container to suction. The reagent position is used for the reagent dispensing part 60 to suck reagents—for example, the reagent carrying part 40 includes a first driving assembly for driving the reagent carrying part 40 to rotate, and the first driving assembly drives the reagent carrying part 40 to rotate to rotate the reagent container to Suction reagent position. The reagent carrying member 40 arranged in a disk-shaped structure will be described in detail below.

4 (a), in some specific embodiments, the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for placing the reagent coupling cup 41, each of the reagent coupling cups 41 includes one or more A cavity for containing reagents required for project testing, a kind of reagent is placed in a cavity; the reagent carrying member 40 includes a first driving component for driving it to rotate, and the first driving component drives the reagent carrying component 40 to rotate , Used to rotate the cavity of the reagent union cup 41 containing the reagents required by the project to the corresponding reagent suction position. In an example, the reagent coupling cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent. For example, the reagent coupling cup 41 includes at least a mixed reagent R1. The first cavity 41a and the second cavity 41b for carrying the trigger reagent R2; the reagent carrying member 40 includes a first reagent suction position and a second reagent suction position different from the first reagent suction position, and the first drive assembly drives The reagent carrying component 40 rotates and drives the reagent coupling cup 41 to rotate to rotate the first cavity 41a of the reagent coupling cup 41 to the first reagent suction position; the first driving assembly drives the reagent carrying component 40 to rotate and drives the reagent coupling cup 41 to rotate , To rotate the second cavity 41b to the second reagent suction position.

Please refer to Figure 4 (b), in some specific embodiments, the reagent carrying member 40 is arranged in a disc-shaped structure, which has a plurality of positions for the first reagent container 42 for carrying the first reagent, and has a plurality of At the position of the second reagent container 43 that carries the second reagent. The reagent carrying component 40 includes a first driving component for driving the rotation of the reagent carrying component 40, and the first driving component drives the reagent carrying component 40 to rotate and drives the first reagent container 42 to rotate, so as to rotate the first reagent container 42 to the first reagent suction position; The first driving component drives the reagent carrying member 40 to rotate and drives the second reagent container 43 to rotate, so as to rotate the second reagent container 43 to the second reagent suction position. In an example, the reagent carrying member 40 may include multiple tracks that can rotate independently. For example, the reagent carrying member 40 may include two tracks-an inner ring and an outer track. A plurality of positions for the first reagent container 42 can be arranged on the outer ring track, and correspondingly, a plurality of second reagents can be arranged on the inner ring track. The position of the container 43 drives the inner ring and the outer ring track to rotate independently through the first drive assembly.

Two types of reagent carrying members 40 have been described above. For example, FIG. 4(a) is an example of placing the reagent coupling cup 41, and FIG. 4(b) is an example of realizing the reagent carrying member 40 through a track that can rotate independently. The skilled person can understand that these two ways can also be combined to realize the reagent carrying member 40 through multiple tracks that can rotate independently, and at least one track or each track has multiple coupling cups 41 for placing reagents. For example, Figure 5 is an example of this. The reagent carrying member 40 can include two tracks—inner and outer tracks. The outer track can be provided with multiple positions for the reagent coupling cup 41. Correspondingly, the inner The ring track may also be provided with multiple positions for placing the reagent coupling cup 41, and the inner ring and the outer ring track are driven to rotate independently by the first drive assembly.

The above are some descriptions of the reagent carrying member 40. The reagent carrying part 40 can rotate and dispatch the corresponding reagent required by the test item to the reagent suction position corresponding to the reagent dispensing part 60 by rotating during the working cycle, for example, dispatch the first reagent to the first reagent suction position, The second reagent is dispatched to the second reagent suction position.

The processing unit 50 is used to receive a reaction cup carrying a sample, and process the sample in the reaction cup. The sample here refers to a reaction solution composed of a sample and a reagent. There may be one or more processing units 50.

Referring to FIG. 6, in some embodiments, at least one of the processing unit 50 is a reaction component 51 for incubating a sample, and the reaction component 51 is used to carry a reaction cup and incubate the sample in the reaction cup. In some embodiments, the reaction component 51 has a rectangular shape and has a plurality of reaction cup placement positions. Generally, the reaction component 51 can heat the reaction solution or sample in the reaction cups on each reaction cup placement position to incubate the sample, for example, heat the sample in the reaction cup and keep it at 37±0.5 ℃, the specific heating time and heating temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction member 51 is arranged along the first direction, for example, along the Y direction in the figure.

In some embodiments, at least one of the processing unit 50 is a measuring part 52 for measuring a sample. The measuring part 52 is used to carry a cuvette and detect the sample in the cuvette; in some embodiments, the measuring part 52 is Rectangular shape, with multiple reaction cup placement positions. Generally, the measuring component 52 can be equipped with a detection part (not shown in the figure) for each reaction cup placement position, and each detection part is used to detect the sample in the reaction cup at the corresponding cuvette placement position. In some embodiments, the length direction of the measuring component 52 is arranged along a second direction different from the first direction, for example, along the X direction in the figure.

In some embodiments, the reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40 in an adjacent manner. In some specific embodiments, the reaction component 51 and the measurement component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying member 40 in an adjacent manner.

The rectangular reaction part 51 and the measuring part 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying part 40 in an adjacent manner, which can save space and reduce the size of the sample analysis device. At the same time, it is also advantageous for the reagent carrying part 40 to interact with the reaction part 51 and the measuring part 52 through the reagent dispensing part 60.

In some embodiments, the sample component 20 such as the sample injection component 21, the cuvette loading component 10, the reaction component 51 and the measurement component 52 are arranged around the reagent carrying component 40. This application is centered on the reagent carrying component 40, and the scheduling trajectory of the entire detection process of the reaction cup is designed around the reagent carrying component 40, which is novel in design and saves space.

Each processing unit 50 may be configured with a corresponding transposition during reagent addition. For example, the reaction component 51 is configured with at least one transposition 51a during incubation for placing a reaction cup, and the number of transposition 51a during incubation can be one or more; When the position of the incubation transposition 51a to place the reaction cup is set to 1, the incubation transposition 51a can be set in a position adjustable manner, so that the reaction cup placed on the incubation transposition 51a can be combined with the first reagent dispensing part (No. A reagent dispensing part is corresponding to the reaction part, and each reagent needle in the reaction cup in the reaction part is corresponding to the position to receive the reagent dispensed by each reagent needle. In some embodiments, the indexing position 51 a is arranged between the reagent carrying part 40 and the reaction part 51 during the incubation. The measurement part 52 is configured with at least one mid-measurement index 52a for placing the reaction cup, and the number of mid-measurement index 52a can be one or more; in some embodiments, the mid-measurement index 52a is provided on the reagent carrying member 40 and Between parts 52. When the position of the measuring index 52a for placing the reaction cup is set to 1, the measuring index 52a can be set in a position adjustable manner, so that the reaction cup placed on the measuring index 52a can be combined with the second reagent dispensing part ( The second reagent dispensing part corresponds to the measuring part, and the reagent needles in the reaction cup in the measuring part are matched in position to receive the reagent dispensed by the reagent needles.

Figure 6 shows that the number of transposition 51a in the incubation is one, and each transposition 51a in the incubation has two placement positions for the reaction cup, for example, the first position and the second position for placing the reaction cup; the transposition 52a is measured during the incubation. The number is one, and each index 52a has two placement positions for the reaction cup in each measurement, for example, the third position and the fourth position for placing the reaction cup.

The reagent dispensing component 60 is used for sucking reagents from the reagent suction position and discharging them into the reaction cup of the reagent adding position. For example, the reagent dispensing part 60 can suck the first reagent from the first reagent suction position mentioned herein and discharge it into the reaction cup; the reagent dispensing part 60 can suck the second reagent from the second reagent position mentioned herein side by side. Put it in the reaction cup. In some embodiments, the reagent dispensing component 60 may be disposed in the casing 1.

The reagent dispensing unit 60 can be realized by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, and the reagent needle is used to suck the reagent from the reagent carrying component 40 and discharge it into the reaction cup.

From the perspective of the number of reagent needles, in some embodiments, the reagent dispensing part 60 may have multiple reagent needles, and the reagent needles are arranged in a manner that can move independently of each other. Specifically, the reagent needles can be configured as follows: each processing unit 50 is equipped with a group of reagent needles; the reagent needles are used to suck reagents from the reagent carrying member 40 and discharge them into the reaction cups of the corresponding processing units 50, and each group of reagent needles At least two reagent needles are included. For example, a set of reagent needles may be configured for the reaction part 51, and a set of reagent needles may be configured for the measurement part 52. In some specific embodiments, the reaction part 51 may be configured with a first set of reagent needles. The first set of reagent needles are arranged in a linear motion between the reagent suction position and the incubation position 51a. The first group of reagent needles For sucking reagents from the reagent suction position and discharging them into the reaction cup located at the incubation position 51a, the first set of reagent needles includes at least one reagent needle; similarly, a second set of reagent needles can be configured for the measurement component 52, and the second set of reagent needles The reagent needles of the group are arranged in a linear motion between the reagent suction position and the indexing position 52a in the measurement. The second group of reagent needles are used to suck reagents from the reagent suction position and discharge them into the reaction cup at the indexing position 52a in the measurement. The second group of reagent needles includes at least one reagent needle.

From the perspective of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. Figures 1 to 3 above are examples of this. Specifically, there may be two reagent dispensing components 60, the reaction component 51 corresponds to one of the reagent dispensing components 60, and the measuring component 52 corresponds to the other reagent dispensing component 60. A reagent dispensing component 60 is configured for each processing unit 50 to decompose the action of the reagent adding process of the test item, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50, which makes The sample addition of the corresponding reagents of the test items is completed by division of labor, which is beneficial to improve efficiency.

The specific structure of the reagent dispensing unit 60 will be described below.

Referring to FIG. 7, each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 for linear movement, and drives the plurality of reagent needles 61 to move along the guide assembly 62 The second drive assembly 63 for linear motion. The guide assembly 62 is arranged along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60, so that the reagent needle 61 sucks the reagent from the reagent suction position and discharges it to the reagent dispensing part. 60 corresponds to the reaction cup of the transposition in the reagent adding process unit 50 of the processing unit 50. For example, the reagent dispensing part 60 on the left side in FIG. 7 has a guide assembly 62 arranged along the direction determined by the incubation position 51a of the reagent suction position and the reaction part 51, so that the reagent needle 61 of the reagent dispensing part 60 is removed from the suction position. The reagent position sucks reagents and discharges them into the reaction cup located at the incubation position 51a; the reagent dispensing part 60 on the right in FIG. 7 is determined by the guide assembly 62 along the reagent suction position and the measuring position 52a of the measuring part 52. The direction is set so that the reagent needle 61 of the reagent dispensing part 60 sucks the reagent from the reagent suction position and discharges it into the reaction cup located at the index 52a in the measurement. In some embodiments, the number of the second driving components 53 of each reagent dispensing part 60 is equal to the number of the reagent needles 61, and the respective independent driving force output ends of the plurality of second driving components 53 act on the plurality of reagent needles 61 accordingly. , So as to independently drive the multiple reagent needles 61 along the guide assembly 52 to move linearly between the reagent suction position and the reagent adding position. For example, the example shown in FIG. 7 is an example in which each reagent dispensing part 60 includes two reagent needles 61, and each reagent needle 61 is independently driven by a respective second driving assembly 63.

There are many ways to implement the guiding component 52, and a few are listed below.

FIG. 8 is a schematic view of the side surface of the reagent dispensing member 60. As shown in FIG. In some embodiments, the guide assembly 62 of each reagent dispensing part 60 includes: a beam 62a, and a plurality of guides 62b arranged in parallel and along the length of the beam 62a; the beam 62a extends along the reagent suction position and corresponds to The processing unit 50 of the reagent dispensing part 60 is set in the direction determined by the transposition in the reagent addition; the number of guides 62b is equal to the number of reagent needles 61 of the reagent dispensing part 60, and the plurality of reagent needles 61 are respectively connected to the plurality of guides 62b is slidably connected, so that the reagent needle 61 moves linearly along the guide 62b between the reagent sucking position and the reagent adding position. In some embodiments, each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guides 62b, and the two guides 62b are linear guides; The two linear guides are respectively arranged on both sides of the beam 62a along the long axis of the beam 62a-Figure 8 shows a schematic diagram of one side of the beam 62a, and the structure on the other side exposes a reagent needle 61; The reagent needles 61 are respectively arranged on the linear guide rails on both sides of the beam 62a and slidably connected with the linear guide rails; the reagent needle 61 moves linearly between the reagent suction position and the reagent adding position along the linear guide rail on which it is located.

This is an embodiment in which a reagent needle is provided on both sides of a beam to realize a reagent dispensing part. In other embodiments, it is also possible to realize a reagent dispensing component by two parallel beams, each beam is provided with only one reagent needle, which will be described in detail below.

9 and 10, in some embodiments, the guide assembly 62 of each reagent dispensing part 60 includes: a plurality of parallel beams 62a, and a plurality of beams 62a are respectively arranged on the plurality of the above and along the above A guide 62b is provided in the length direction of the cross beam 62a; a plurality of the above cross beams 62a are provided along the direction determined by the reagent suction position and the reagent adding position of the processing unit 50 corresponding to the reagent dispensing part 60; the number of the guide 62b is related to the reagent distribution. The number of reagent needles 61 of the injection part 60 is equal, and the reagent needles 61 are respectively slidably connected to the guide members 62b, so that the reagent needles 61 move linearly along the guide member 62b between the reagent suction position and the reagent adding position. In some embodiments, the plurality of guides 62b of each reagent dispensing part 60 are linear guides, and the plurality of linear guides are respectively arranged along the longitudinal direction of the plurality of beams 62a; the plurality of reagent needles 61 are respectively arranged on the plurality of beams 62a. 62a is on the linear guide rail and is slidably connected to the linear guide rail; the reagent needle 61 moves linearly between the reagent suction position and the reagent loading position along the linear guide rail where it is located.

In some embodiments, the beam 52a of the guide assembly 52 in each reagent dispensing component 60 is fixedly arranged at the reagent suction position and the upper position of the reagent adding position of the processing unit 50 corresponding to the reagent dispensing component 60.

The cross-beam structure realizes the reagent dispensing part 60 with multiple needles moving linearly. The movement trajectory of the reagent needle 61 does not take up too much space and minimizes the layout interference with other parts, so that the structure of the sample analysis device can be more compact and very compact. It is conducive to the miniaturization design of the sample analysis device.

In some embodiments, the trajectories of the reagent needles 61 of different reagent dispensing parts 60 do not intersect each other, so that the movement of the reagent needles 61 of different reagent dispensing parts 60 will not be interfered with each other. , Is conducive to improving the test speed.

In some embodiments, there is at least one processing unit 50, and the transposition during reagent addition includes the same number of reaction cup placement positions of the reagent needle 61 of the reagent dispensing part 60 corresponding to the processing unit 50. For example, in the example in FIG. 6, the reagent-adding transposition of the reaction component 51 is the incubation transposition 51a in the figure, and the incubation transposition 51a can place two reaction cups; the reagent of the reagent dispensing component 60 corresponding to the reaction component 51 The number of needles 61 is two. In Fig. 6, the reagent-adding indexing position of the measuring part 52 is the measuring indexing position 52a in the figure. The measuring indexing position 52a can hold two reaction cups; the number of reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 There are two. In some embodiments, the number of reagent suction positions is the same as the number of reagent needles. For example, there are two reagent dispensing parts 60 in FIG. 6, and each reagent dispensing part 60 has two reagent needles 61, so the number of reagent suction positions is four. The number of reagent needles and the number of reagent adding positions are the same, so that each reagent needle can clearly divide the labor, and adding reagents to the reaction cups on the respective reagent adding positions is beneficial to increase the test speed.

In some embodiments, the reagent needle 61 in the same reagent dispensing part 60 is used to suck the same type of reagent. For example, the reagent needles 61 of the reagent dispensing part 60 corresponding to the reaction part 51 are all used for aspirating the first reagent, and the reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 are all used for aspirating the second reagent. Different reagent dispensing parts 60 are used to suck different reagents, which makes the division of labor of each reagent dispensing part 60 clear, which is beneficial to increase the test speed.

In some embodiments, each reagent needle 61 of the reagent dispensing component 60 is provided with a heating component (not shown in the figure) for heating the reagent sucked by the reagent needle. Since each reagent dispensing part 60 includes multiple reagent needles 61, two reagent needles may be used as an example. Each reagent needle 61 is further provided with a heating part. Since there are two reagent needles 61, the original speed is maintained. Each reagent needle 61 has sufficient time—for example, doubled the time to heat the sucked reagent, so that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already relatively close to the predetermined temperature, that is, The reagents have been fully preheated.

The above are some descriptions of the reagent dispensing unit 60. Hereinafter, the number of the processing unit 50 may be two, and specifically the reaction component 51 and the measuring component 52 as an example, to illustrate the matching relationship and the corresponding structure of the reagent dispensing component 60 and the processing unit 50.

In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measuring component 52 is a second reagent dispensing component, which will be described in detail below.

In some embodiments, the first reagent dispensing part 60 includes a first beam 6a and a first set of reagent needles. The first set of reagent needles includes at least a plurality of first reagent needles 6b, such as two; 61 is arranged on the first beam 62a and moves linearly along the long axis of the first beam 62a to suck the first reagent from the first reagent suction position and discharge it into the reaction cup located at the incubation position 51a. In some embodiments, the first beam 62a is arranged along the direction determined by the first reagent suction position and the incubation index 51a, and the first beam 62a is fixed at the upper position corresponding to the first reagent suction position and the incubation index 51a.

In some embodiments, the first crossbeam 62a of the first reagent dispensing part 60 is set as one, and the multiple first reagent needles 61 described above are arranged in parallel on this first crossbeam 62a, and are arranged along the first crossbeam 62a. Make a linear movement in the direction of the long axis. Taking the first group of reagent needles with two first reagent needles 61 as an example, a linear guide rail is respectively provided on both sides of the first cross beam 62a along the long axis direction, and the two first reagent needles 61 are respectively provided on the first cross beam 62a. On the linear guide rails on both sides, the first reagent needle 61 moves linearly along the linear guide rail where it is located between the first reagent suction position and the incubation index 51a. This is an embodiment in which a first reagent needle is provided on both sides of a first beam to realize the first reagent dispensing part.

In some embodiments, the number of the first beams 62a of the first reagent dispensing part 60 is equal to the number of the first reagent needles 61 of the first group of reagent needles, and each of the first beams 62a is provided with a first reagent. Needles 61, and two of the above-mentioned first beams 62a are arranged parallel to each other. In some specific embodiments, each of the plurality of first beams 62a is provided with a linear guide along its long axis, and the plurality of first reagent needles 61 are respectively provided on the linear guides of the plurality of first beams 62a for the first reagent The needle 61 moves linearly between the first reagent suction position and the incubation position 51a. This is the implementation of the first reagent dispensing part by means of multiple, for example, two parallel first beams, and each first beam is provided with only one first reagent needle.

In some embodiments, the first reagent dispensing component 60 further includes a plurality of driving mechanisms that independently drive a plurality of first reagent needles to move linearly, such as a second driving assembly, the number of the plurality of second driving assemblies is different from the number of the first reagent needles. The number of reagent needles is equal, and the independent driving force output ends of the plurality of second driving components act on the plurality of first reagent needles to drive the plurality of first reagent needles in the first suction along the long axis direction of the first beam. There is a linear movement between the reagent position and the transposition 51a during the incubation.

As an example, the indexing position 51a in the above incubation includes the first position and the second position for placing the reaction cup as an example. Then, in the example in which the first reagent dispensing part 60 has two first reagent needles 61, one of the first reagent needles 61 is The reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the first position, and the other first reagent needle 61 moves linearly along the first beam 62a between the first reagent suction position and the second position .

In some embodiments, the first reagent dispensing component 60 further includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction. The number of the components 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles; the first Z-direction drive components 64 all include: a first Z-direction for guiding the first reagent needle 61 to move in the vertical direction A guide member 64a, and a first Z-direction driving member 64b for driving the first reagent needle to move along the first Z-direction member; the first reagent needle 61 is driven by the first Z-direction member 64a and the first Z-direction The member 64b forms a sliding connection with the first beam 62a, so that the first reagent needle 61 can move in the vertical direction relative to the first beam 62a under the drive of the first Z-direction driving member 64b. Those skilled in the art can understand that when the reagent needle performs a reciprocating linear motion, it needs to move in a vertical direction when reaching each position to complete operations such as reagent suction and discharge.

In some embodiments, the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.

The above is some explanations about the first reagent dispensing part 60, and the second reagent dispensing part 60 will be explained below.

The second reagent dispensing part 60 includes a second beam 62a and a second set of reagent needles. The second set of reagent needles includes at least a plurality of second reagent needles 61, such as two; the plurality of second reagent needles 61 are provided in the second group of reagent needles. On the beam 62a and move linearly along the long axis of the second beam 62a to suck the second reagent from the second reagent suction position and discharge it into the reaction cup located at the index 52a in the measurement. In some embodiments, the second beam 62a is arranged along the direction determined by the second reagent suction position and the measuring index 52a, and the second beam 62a is fixedly arranged at the upper position corresponding to the second reagent suction position and the measuring index 52a.

In some embodiments, the second crossbeam 62a of the second reagent dispensing part 60 is provided as one, and the multiple second reagent needles 61 described above are provided in parallel on this second crossbeam 62a and run along the second crossbeam 62a. Make a linear movement in the direction of the long axis. Taking the second set of reagent needles with two first reagent needles 61 as an example, a linear guide rail is respectively provided on both sides of the second cross beam 62a along the long axis direction, and the two second reagent needles 61 are respectively provided on the second cross beam 62a. On the linear guide rails on both sides, the second reagent needle 61 moves linearly between the second reagent suction position and the measuring index 52a along the linear guide rail where it is located. This is an embodiment in which a second reagent needle is provided on both sides of a second beam to realize the second reagent dispensing part.

In some embodiments, the number of the second beams 62a of the second reagent dispensing part 60 is equal to the number of the second reagent needles 61 of the second group of reagent needles, and each of the second beams 62a is provided with a second reagent. Needles 61, and two of the above-mentioned second beams 62a are arranged parallel to each other. In some specific embodiments, each of the plurality of second beams 62a is provided with a linear guide along its long axis, and the plurality of second reagent needles 61 are respectively provided on the linear guides of the plurality of second beams 62a for the second reagent. The needle 61 moves linearly between the second reagent suction position and the measuring index 52a. This is the implementation of the second reagent dispensing part by means of multiple, for example, two parallel second beams, and each second beam is provided with only one second reagent needle.

In some embodiments, the second reagent dispensing component 60 further includes a plurality of driving mechanisms that are different from the second driving assembly and independently drive a plurality of second reagent needles to move linearly, such as a third driving assembly, and a third driving mechanism. The number of driving components is equal to the number of the second reagent needles, and the independent driving force output ends of the third driving components act on the second reagent needles to drive the second reagent needles. The reagent needle moves linearly along the long axis direction of the second beam between the second reagent position and the indexing position in the measurement. The structure of the second driving component and the third driving component may be the same.

As an example, the indexing position 52a includes the third position and the fourth position for placing the reaction cup in the above-mentioned measurement. Then, in the example in which the second reagent dispensing part 60 has two second reagent needles 61, one of the second reagent needles 61 is The reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the third position, and the other second reagent needle 61 moves linearly along the second beam 62a between the second reagent suction position and the fourth position .

In some embodiments, the second reagent dispensing component 60 further includes a second Z-direction driving assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction, respectively, and the second Z-direction driving The number of the components 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles; the second Z-direction drive components 64 all include: a second Z-direction for guiding the second reagent needle 61 to move in the vertical direction The guide member 64a, and the second Z-direction driving member 64b for driving the second reagent needle 61 to move along the second Z-direction member 64a; the second reagent needle 61 is driven by the second Z-direction member 64a and the second Z-direction The member 64b forms a sliding connection with the second beam 62a, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z-direction driving member 64b.

In some embodiments, the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked by it.

In some embodiments, the trajectory of the linear movement of the plurality of first reagent needles 61 of the first reagent dispensing component 60 between the first reagent suction position and the incubation position 51a is the first movement trajectory; The trajectory of the linear movement of the multiple second reagent needles 61 of the injection component 60 between the second reagent suction position and the indexing position 52a in the measurement is the second movement trajectory; wherein the first movement trajectory is different from the second movement trajectory cross.

The structure of the first reagent dispensing part 60 and the second reagent dispensing part 60 may be the same, except that they are arranged in different directions. The first reagent dispensing part 60 is arranged in the direction of the reaction part 51 to be used with the reaction part 51. In cooperation, the second reagent dispensing part 60 is provided in the direction of the measuring part 52 to cooperate with the measuring part 52.

The above are some descriptions of the reagent dispensing unit 60. The reagent dispensing part 60 adopts a beam structure, so that the reagent needle 61 continuously reciprocates between the reagent suction position of the reagent carrying part 40 and the reagent adding position of the corresponding processing unit to complete the suction and discharge of the corresponding reagent.

The movements of the different reagent dispensing parts 60 are independent and do not interfere with each other, and therefore play a significant role in the miniaturization of the instrument space and the improvement of the test speed.

The scheduling component 70 is used to schedule the reaction cups. For example, the scheduling component 70 schedules the reaction cups located in the sample loading position to complete the sample addition to each processing unit 50 according to the detection process. For example, the scheduling component 70 transfers the reagents to the position 51a during the incubation. For example, the reaction cup of the first reagent is dispatched to the reaction unit 51, and the reaction cup to which the reagent such as the second reagent has been added to the index 52a during the measurement is dispatched to the measurement unit 52. The specific structure of the scheduling component 70 will be described below.

Referring to FIG. 11, in some embodiments, the scheduling component 70 includes a first transfer component 71, a second transfer component 73, and a third transfer component 75. In order to cooperate with these three

transfer components

71, 73, and 75, in some embodiments, the sample The analysis device is also provided with a first buffer index 77 and a second buffer index 78. In some embodiments, the index 77 in the first buffer can be designed with a fixed buffer position, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device; similarly, the first The indexing position 78 in a buffer can be designed with a fixed buffer position, and has only one reaction cup placement position, that is, only one reaction cup can be placed, which is beneficial to reduce the volume and size of the sample analysis device. Of course, in some embodiments, when the first buffer index 77 and the second buffer index 78 adopt a fixed buffer design, they can also be designed to have multiple cuvette placement positions, so that there are more cuvettes in the scheduling. Place a bit. Furthermore, in some embodiments, the index 77 in the first buffer may be designed as a moving or rotating buffer position. For example, the index 77 in the first buffer may include a reaction cup placement position that can be driven to move or rotate. In the process that the transfer component 71 transfers the cuvette to the first buffer index 77, the first buffer index 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the first transfer part 71. In addition, when the second transfer part 73 needs to transfer away the cuvette on the first buffer index 77, the first buffer index 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer part 73 Faster grabbing the cuvette on the index 77 in the first buffer; similarly, the index 78 in the second buffer may include a cuvette placement position that can be driven to move or rotate, so that the reaction cup in the second transfer part 73 During the transfer of the cuvette to the index 78 in the second buffer, the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred from the second transfer member 73. In addition, in the third When the transfer part 73 needs to transfer the cuvette on the index 78 in the second buffer, the index 78 in the second buffer can also be controlled to move or rotate to a predetermined position so that the third transfer part 75 can grab faster Transfer the reaction cup on 78 to the second buffer; through this design, the entire transfer process of the reaction cup can be made faster and less time-consuming, which improves the efficiency and test speed of the sample analysis device.

There are many specific implementations of the first transfer component 71, the second transfer component 73 and the third transfer component 75, such as a rail-type transfer component, which transfers the cuvette by placing the cuvette on the rail; another example is a turntable type. By placing the reaction cup on the turntable structure, the reaction cup carried by the turntable is transferred to the corresponding position by the transfer of the turntable itself; for example, the two-dimensional or three-dimensional drive mechanism is used to drive the gripper In this way, the first transfer part 71, the second transfer part 73 and the third transfer part 75 are realized. The reaction cup is grasped by the cup grasping hand, and then the two-dimensional or three-dimensional driving mechanism is used to drive the cup grasping hand to move. The cuvette is transferred to the corresponding position, and the following description may be given by using a cup gripper to realize the transfer part.

12(a), the first transfer component 71, the second transfer component 73 and the third transfer component 75 all include a cup gripper 79 and a driving component for driving the cup gripper 79 to move. In some embodiments, the cup gripper 79 is used to hold the reaction cup. For example, FIG. 13 is a schematic structural diagram of the cup gripper 79. The opening and closing of the cup gripper 79 can be realized by a driving mechanism and a spring. The opening of the cup gripper 79 can be driven by its driving mechanism. When the driving mechanism is not driven, the cup gripper 79 is automatically opened by its spring. Close and clamp the clamped object, such as a reaction cup. In some cases, a circle of protrusions adapted to be held by the gripping hand can be provided on the reaction cup.

The following describes the transport components and their functions.

The first transport component 71 is used for transporting the reaction cup after the sample addition is completed to the transfer position 77 in the first buffer. In some embodiments, the first transfer component 71 moves linearly in a first direction, such as the Y direction in the figure, and transports the reaction cup after sample loading to the index 77 in the first buffer. Since the first transfer component 71 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturized design of the sample analysis device.

Please refer to FIG. 14, in some embodiments, the sample analysis device may also be provided with a sample adding position 10 a, a pre-dilution position 10 b, a first throwing cup position 10 c, and a second throwing cup position 10 d. In some embodiments, the first transfer component 71 can move between the sample loading position 10a, the pre-dilution position 10b, the first throwing cup position 10c, and the first buffer indexing position 77 along the first direction, such as the Y direction in the figure. The sample loading position 10a may be the predetermined position where the empty reaction cup is loaded by the reaction cup loading part 10 mentioned above. Generally, the sample dispensing part 30 sucks the sample from the sample suction position and discharges it to the sample loading position. 10a in the reaction cup to complete the sample addition. In some cases, the sample needs to be pre-diluted. Therefore, in this case, the first transfer component 71 first transfers the empty cuvette on the sample loading position 10a to the pre-dilution position 10b, and the sample dispensing component 30 sucks from the sample suction position The samples are discharged side by side into the reaction cup at the pre-dilution position 10b, and then the sample in the reaction cup at the pre-dilution position 10b is diluted; in this process, the reaction cup loading part 10 loads a new empty reaction cup into the sample Position 10a, and then the sample dispensing component 30 sucks the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it to the sample addition position 10a to complete the sample addition; the first transfer component 71 then pre-dilutes The reaction cup on position 10b is tossed, for example, it is transferred to the first toss position 10c for the tossing.

As mentioned above, in some embodiments, the first transfer component 71 only needs to move in the first direction, so the driving component of the first transfer component 71 may be a two-dimensional drive component for driving the first transfer component 71 The cup gripper 79 moves along a first direction and a vertical direction, where the first direction can be the Y direction in the figure, and the vertical direction is a direction perpendicular to the paper in the figure. 12(b), in some embodiments, the first transfer member 71 includes a first direction guide 71a, a first direction drive member 71b, a vertical direction guide 71c, and a vertical direction drive member 71d; The guide 71c is slidably provided with the cup gripper 79 of the first transfer component 71, and is driven by the vertical direction guide 71c, so that the cup gripper 79 can move in the vertical direction along the vertical direction guide 71c; The direction guide 71a is slidably provided with a vertical direction guide 71c, and driven by the first direction driving member 71b, the vertical direction guide 71c can move in the first direction along the first direction guide 71a, thereby driving The cup gripper 79 of the first transfer component 71 also moves in the first direction. With this structure, the cup gripper 79 of the first transfer component 71 can be moved in the first direction and the vertical direction. . In some specific embodiments, the first direction guide 71a may include a first guide rail; the first direction driving component 71b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the vertical direction guide 71c may be fixedly connected to the first timing belt; similarly, the vertical direction guide 71c may include a vertical guide rail; the vertical direction drive member 71d may It includes an elevating stepping motor and a vertical screw rod. A mounting plate can be threaded on the vertical screw rod for mounting the cup gripper 79 of the first transfer component 71. In some embodiments, the first transfer component 71 may further include a first bracket 71f for installing the above-mentioned first direction guide 71a.

In some embodiments, the cup gripper 79 of the first transport component 71 grabs, for example, the cuvette on the sample loading position 10a in the second direction, such as the X direction in the figure, so that the first transport component 71 does not grab the cuvette. Affect the sample dispensing part 30 to discharge the sample into the reaction cup, so that the first transfer part 71 can grasp the reaction cup while the sample dispensing part 30 completes the sample addition of the reaction cup, which saves time and improves the measurement speed and measurement speed. effectiveness.

The above is some descriptions of the first transfer component 71.

The second transfer component 73 is used to transfer the cuvettes indexed 77 in the first buffer to the reaction part 51, and to transfer the reaction cups after the sample incubation in the reaction part 51 is completed to the index 78 in the second buffer. In some embodiments, the second transfer component 73 transports the cuvette of the index 77 in the first buffer to the reaction component 51 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. , And transport the reaction cup in which the sample incubation is completed in the reaction part 51 to the index 78 in the second buffer. Since the second transfer member 73 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.

In the specific transfer process, the second transfer component 73 can first transport the reaction cup of the first buffer index 77 to the incubation index 51a, and the reagent dispensing part 60 sucks the reagent and discharges it into the reaction cup located in the incubation index 51a. , The second transfer part 73 then transfers the cuvette with the transposition 51a during the incubation to the reaction part 51.

In some embodiments, the second transfer member 73 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing), so the second The driving part of the transporting part 73 may be a three-dimensional driving part for driving the cup gripper 79 of the second transporting part 73 to move in the first direction, the second direction and the vertical direction. 12(c), in some embodiments, the second transfer member 73 includes a first direction guide 73a, a first direction driving member 73b, a second direction guide 73c, a second direction driving member 73d, and a vertical direction. The guide member 73e and the vertical direction driving member 73f; the vertical direction guide member 73e is slidably provided with the cup gripper 79 of the second transfer member 73, and the vertical direction guide member 73f is driven so that the cup gripper 79 can move along The vertical direction guide 73e moves in the vertical direction; the second direction guide 73c is slidably provided with a vertical direction guide 73e, and is driven by the second direction driving member 73d, so that the vertical direction guide 73e can move along the first direction. The two-direction guide 73c moves in the second direction, thereby driving the cup gripper 79 of the second transfer member 73 to also move in the second direction; the first-direction guide 73a is slidably provided with a second-direction guide 73c, and Driven by the first-direction driving member 73b, the second-direction guide 73c can move in the first direction along the first-direction guide 73a, thereby driving the second-direction guide 73c to also move in the first direction. Drive the vertical direction guide member 73e on the second direction guide member 73c to move in the first direction, so that the cup gripper 79 of the second transfer member 73 on the vertical direction guide member 73e can also move in the first direction; With such a structure, the cup gripper 79 of the second transport member 73 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction. In some specific embodiments, the first direction guide 73a may include a first guide rail; the first direction driving component 73b may include a first stepper motor, a first driven wheel, and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 73c can be fixedly connected to the first timing belt; similarly, the second direction guide 73c can include a second guide rail; the second direction drive part 73d can be It includes a second stepping motor, a second driven wheel and a second timing belt. The second timing belt is sleeved between the second stepping motor and the second driven wheel. The vertical direction guide 73e can be fixed to the second timing belt. Similarly, the vertical direction guide 73e can include a vertical guide rail; the vertical direction driving part 73f can include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The cup gripper 79 is installed on the second transfer component 73. In some embodiments, the second transfer component 73 may further include a second bracket 73g for installing the above-mentioned first direction guide 73a.

In some embodiments, the gripper 79 of the second transfer component 73 grips the cuvette in a second direction, such as the X direction in the figure, so that the second transfer component 71 will not affect the reagent dispensing component 60 when gripping the cuvette. The first reagent dispensing part adds reagents to the reaction cup, so that the second transfer part 73 can grasp the reaction cup while the reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency. . In some embodiments, the direction in which the second transfer component 73 grabs the reaction cup and the direction of the linear movement of the first set of reagent needles are greater than 90 degrees. In this case, the second transfer component 73 grabs the reaction cup and the first set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.

In some embodiments, the second transfer component 73 transports the reaction cup from the incubation position 51a to the reaction component 51, and also mixes the sample in the reaction cup. For example, the second transfer component 73 transfers the sample-loaded reaction cup from the first buffer to the transposition 77 and places it in the incubation transposition 51a. The reagent dispensing component 60 then adds reagents to the reaction cup on the transposition 51a in the incubation. For reagents, the second transfer component 73 picks up the reaction cup with reagents added, mixes it, and then transfers it to the reaction component 51; specifically, the second transfer component 73 can drive the cup gripper 79 through the drive component 71b Shake quickly to achieve mixing of the sample in the reaction cup gripped by the cup gripper 79. The second transfer component 73 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the second transfer component 73 is grabbing Mixing the cuvette when it is ready for transfer also saves time, and there is no need to dispatch the cuvette to the corresponding mixing mechanism for mixing.

The above are some descriptions of the second transfer component 73. The second transfer part 73 can and realize the transfer of the cuvette between the first buffer and the incubation part 51a, the reaction part 51 and the second buffer part 78 by linear movement along the first direction and the second direction. .

The third transfer part 75 is used to transfer the cuvettes indexed 78 in the second buffer to the measurement part 52. In some embodiments, the third transfer component 75 transports the cuvette of the index 78 in the second buffer to the measurement component 52 through a linear movement in a first direction, such as the direction in the figure, and a linear movement in a second direction, such as the X direction in the figure. . Since the third transfer member 75 moves in a straight line to move the reaction cup, the volume of the sample analysis device occupied during the transportation of the reaction cup is relatively reduced, which is beneficial to the miniaturization design of the sample analysis device.

During the specific transfer process, the third transfer component 75 may first transport the cuvette of the index 78 in the second buffer to the index 52a in the measurement, and the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette at the index 52a in the measurement. The third transfer part 75 then transfers the cuvette with the index 75 a during the measurement to the measurement part 52. In some embodiments, when the third transfer component 75 transfers the cuvette from the second buffer translocation 78 to the measurement translocation 52a, the third transfer component 75 may not place the cuvette in the measurement translocation 52a, but still grasp it. Take the cuvette. In this case, the reagent dispensing part 60 sucks the reagent and discharges it into the cuvette, so that the time for the cuvette to be transposed from the second buffer 78 and finally enter the measuring part 52 is reduced, and the test speed is increased. .

In some embodiments, the third transfer member 75 can move in the first direction (for example, the Y direction in the figure), the second direction (for example, the X direction in the figure), and the vertical direction (for example, the direction perpendicular to the drawing). The driving part of the transfer part 75 may be a three-dimensional driving part for driving the cup gripper 79 of the third transfer part 75 to move in the first direction, the second direction and the vertical direction. 12(d), in some embodiments, the third transfer member 75 includes a first direction guide 75a, a first direction drive member 75b, a second direction guide 75c, a second direction drive member 75d, and a vertical direction The guide member 75e and the vertical direction driving member 75f; the vertical direction guide member 75e is slidably provided with the cup gripper 79 of the third transfer member 75, and the vertical direction guide member 75f is driven so that the cup gripper 79 can move along The vertical direction guide 75e moves in the vertical direction; the second direction guide 75c is slidably provided with a vertical direction guide 75e, and is driven by the second direction driving member 75d, so that the vertical direction guide 75e can move along the first direction. The two-direction guide 75c moves in the second direction, thereby driving the cup gripper 79 of the third transfer member 75 to also move in the second direction; the first-direction guide 75a is slidably provided with a second-direction guide 75c, and Driven by the first direction driving member 75b, the second direction guide 75c can move in the first direction along the first direction guide 75a, thereby driving the second direction guide 75c to also move in the first direction, so that the second direction guide 75c can also move in the first direction. Drive the vertical direction guide member 75e on the second direction guide member 75c to move in the first direction, so that the cup gripper 79 of the third transfer member 75 on the vertical direction guide member 75e can also move in the first direction; With such a structure, the cup gripper 79 of the third transport member 75 can be moved in the three-dimensional directions of the first direction, the second direction, and the vertical direction. In some specific embodiments, the first direction guide 75a may include a first guide rail; the first direction driving component 75b may include a first stepper motor, a first driven wheel and a first timing belt, and the first timing belt is sleeved on Between the first stepping motor and the first driven wheel, the second direction guide 75c can be fixedly connected to the first timing belt; similarly, the second direction guide 75c can include a second guide rail; the second direction drive member 75d can Including a second stepping motor, a second driven wheel and a second timing belt, the second timing belt is sleeved between the second stepping motor and the second driven wheel, the vertical direction guide 75e can be fixed with the second timing belt Similarly, the vertical direction guide 75e may include a vertical guide rail; the vertical direction driving part 75f may include a lifting stepping motor and a vertical screw rod, the vertical screw rod can be threaded with a mounting plate, with The gripper 79 for installing the third transfer component 75. In some embodiments, the third transfer member 75 may further include a second bracket 75g for installing the above-mentioned first direction guide 75a.

In some embodiments, the gripper 79 of the third transfer component 75 grips the cuvette in the first direction, such as the Y direction in the figure, so that the third transfer component 75 grasps the cuvette at the same time—even if the third transfer component 75 The reaction cup is grasped during the entire reagent addition process, and it will not affect the reagent dispensing part 60, such as the second reagent dispensing part, to add reagents to the reaction cup, so that the third transfer part 75 can grasp the reaction cup at the same time. The reagent dispensing part 60 completes the addition of reagents to the reaction cup, which saves time and improves the measurement speed and efficiency. In some embodiments, the direction in which the third transfer component 75 grabs the cuvette and the direction of the linear movement of the second set of reagent needles are greater than 90 degrees. In this case, the third transfer component 75 grabs the reaction cup and the second set of reagent needles. It is less likely to conflict between the actions of adding reagents, and the two can perform corresponding actions independently and in parallel very reasonably.

In some embodiments, the third transport component 75 mixes the sample in the cuvette during the process of transporting the cuvette from the in-measuring transposition 52a to the measuring component 52. For example, when the third transfer unit 75 transfers the cuvette from the second buffer to the mid-measurement translocation 52a-in some embodiments, the third transfer unit 75 transfers the cuvette to the mid-measurement translocation 52a without dropping the reaction. The cuvette is still grasped underneath; the reagent dispensing part 60 then adds reagents such as the second reagent to the cuvette at 52a during the measurement, and the third transfer part 75 then adds the sample to the cuvette that was grasped. Perform mixing, and then transfer to the measuring part 52; specifically, the third transfer part 75 can drive the cup grasping hand 79 to shake quickly through the driving part 71b to realize the test in the reaction cup grasped by the cup grasping hand 79. Mix the same. The third transfer component 75 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, which makes the sample analysis device more compact and reduces the cost; in addition, the third transfer component 75 For example, the transposition 52a is used to mix the reaction cup on the transport path in the measurement, which also saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.

In some examples, after the third transfer component 75 dispatches the reaction cup to the measurement component 52, it can also grab the measured reaction cup in the measurement component 52, and then transfer it to the second throwing cup position 10d for cup throwing. In an embodiment, the second cup throwing position 10d can be arranged near the index 78 in the second buffer, or between the measuring part 52 and the index 78 in the second buffer, so that the third transfer part 75 moves from the measuring part 52 to the index 78. When the index 78 in the second buffer is used to transfer the cuvette on the index 78 in the second buffer, the measured cuvette on the measuring component 52 can be thrown away by the way, thereby saving time and improving test efficiency.

The above are some descriptions of the third transfer component 75. The third transfer part 75 can and realize the transfer of the reaction cup between the second buffer 78, the measurement 52a, the measurement part 52 and even the second throwing position 10d by linear movement in the first direction and the second direction. .

The above is the description of the scheduling component 70 of some embodiments of the present invention. The application uses three transport components, namely the first transport component 71, the second transport component 73 and the third transport component 75 to complete the rapid transport of the cuvette. The scheduling path is simple and direct, which is conducive to the speed-up of the sample analysis device; in conjunction with the two buffer transfer positions, namely the first buffer transfer position 77 and the second buffer transfer position 78, the transition between the three transfer components is completed, and the structure is also Simple and compact.

The above is the sample analysis device disclosed in some embodiments of the present invention. It is understandable that the sample analysis device disclosed in the present invention may also include some other structures, such as the cleaning component 80 and/or the processor 90, etc., which will be specifically described below with reference to FIG. 15 and FIG. 16.

The cleaning component 80 is used for cleaning the reagent needles, for example, cleaning the first reagent needle and the second reagent needle. Specifically, the cleaning component 80 may include multiple cleaning tanks 81, and the number of cleaning tanks 81 may be the same as the number of reagent needles. For example, when the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component, each reagent When the dispensing parts both include two reagent needles, the number of cleaning tanks can be four. A washing tank can be set on the linear movement track of each reagent needle for cleaning the reagent needle. Referring to FIG. 16, the cleaning component 80 is used to clean the reagent needle. Specifically, the inner wall and the outer wall of the reagent needle may be cleaned by a cleaning solution. The cleaning component 80 includes a cleaning tank, a pipeline, an on-off valve arranged on the pipeline, and the like in the figure. The end of the reagent needle can be connected to a pipeline, which is opened and closed by the on-off valve SV01. When the on-off valve SV01 is opened, the cleaning fluid can reach the end of the reagent needle through the pipeline, flow through the inner wall of the reagent needle, and from The front end of the reagent needle flows out to complete the cleaning of the inner wall of the reagent needle by the cleaning solution. The cleaning chamber is also connected to a pipeline, which is opened and closed by the on-off valve SV02. When the on-off valve SV02 is opened, the cleaning fluid can reach the cleaning chamber through the pipeline, and spray from the cleaning chamber wall to the outer wall of the reagent needle. Finish cleaning the outer wall of the reagent needle with the cleaning solution. The lower end of the cleaning chamber is connected to a waste liquid suction valve SV03 through a pipeline. When the waste liquid suction valve SV03 is opened, the cleaned waste liquid flows out through the lower end of the cleaning chamber. During specific cleaning, the reagent needle comes to the top of the cleaning chamber, and then moves downward to extend the part of the reagent needle (at least the part of the needle that touches the reagent liquid surface when sucking the reagent) into the cleaning chamber, so that the cleaning chamber sprays. The cleaning solution can be used to clean the part of the needle body where the reagent needle touches the liquid surface to complete the cleaning of the reagent needle. Each cleaning tank 81 can share the same set of liquid paths to provide cleaning liquid for cleaning the reagent needles.

The following describes some specific working procedures of the sample analysis device.

The sample analysis device in some embodiments may work in this way.

The cuvette loading part 10 supplies and carries empty cuvettes. For example, the cuvette loading part 10 may load an empty cuvette to a predetermined position, and the predetermined position may be used as a sample loading position. The sample component 20, such as the sample injection component 21, dispatches the sample rack carrying the sample to the sample suction position. The sample dispensing component 30 draws samples from the sample suction position and dispenses them into the reaction cup. For example, the sample dispensing component draws samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.

The driving part of the reagent carrying part 60 drives the reagent carrying part 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing part 60 sucks the first reagent in the reagent container through the first reagent suction position, and is indexed in the first reagent suction position and the reagent addition of the reaction part 51 A linear motion is made between them to dispense the first reagent into the reaction cup indexed in the reagent addition of the reaction part 51. The transposition in the reagent addition of the reaction part 51 may be the transposition 51a in the incubation mentioned herein. In some embodiments, the two first reagent needles 61 of the first reagent dispensing part 60 independently move linearly between the first reagent suction position and the reagent adding position of the reaction part 51. In this way, the two first reagent needles 61 of the first reagent dispensing part 60 can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part 51, which improves Improve the test speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the first reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles 61 of the first reagent dispensing part 60 can avoid occupying public resources as much as possible, so that the number of parts providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged. The action sequence of the first reagent needle 61 also avoids their mutual influence as much as possible, which is very beneficial to the speed-up of the sample analysis device.

The scheduling component 70 schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component 51 for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measuring component 52 for indexing. The mid-reagent transposition of the measuring part 52 may be the mid-measure transposition 52a mentioned herein.

The reagent carrying member 40 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing part 60 sucks the second reagent in the reagent container through the second reagent suction position, and acts between the second reagent suction position and the reagent adding position of the measuring part. It moves linearly to dispense the second reagent into the reaction cup indexed in the reagent addition of the measuring part 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing part 60 independently move linearly between the second reagent suction position and the indexing position of the measuring part 52 during reagent addition. In this way, the two second reagent needles 61 of the second reagent dispensing part 60 can be separately and independently-for example, alternately completing the operation of adding the second reagent to the reaction cup on the transposition in the reagent addition of the measuring part 52, which improves Improve the test speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing part 60 performs multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles 61 Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles 61 of the second reagent dispensing part 60 can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two reagent needles can be arranged. The action timing of the second reagent needle also minimizes their mutual influence, which is very beneficial to the speed-up of the sample analysis device.

The scheduling component 70 schedules the reaction cup that has completed the dispensing of the second reagent to the measurement component 52 for item detection, and schedules the reaction cup after the detection to the waste recovery device—for example, the second throwing cup position mentioned herein.

A sample analysis method is also disclosed in some embodiments of the present invention. Referring to FIG. 17, in some embodiments, the sample analysis method includes the following steps:

Step 100, namely the reaction cup loading step, controls the supply of the reaction cup loading parts and carries the empty reaction cup. For example, the cuvette loading part can load an empty cuvette to a predetermined position, and the predetermined position can be used as a sample loading position.

Step 110, that is, the sample feeding step, controls the sample component, such as the sample injection component, to dispatch the sample rack carrying the sample to the sample suction position.

In step 120, the sample dispensing step, the sample dispensing component is controlled to draw a sample from the sample suction position and dispense it into the reaction cup. For example, the sample dispensing component sucks samples from the sample suction position and discharges them to the reaction cup located on the sample addition position to complete the sample addition.

Through the above steps 100 to 120, the sample addition is completed.

In step 130, the first reagent dispensing step, the driving part of the reagent carrying part is controlled to drive the reagent carrying part to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position; At least one of the two reagent needles sucks the first reagent in the reagent container through the first reagent sucking position, and moves linearly between the first reagent sucking position and the indexing position of the reagent in the reaction part to add to the reaction part. The transposed reaction cup among the reagents dispenses the first reagent. The translocation in the reagent addition of the reaction component in step 130 may be the translocation in the incubation mentioned herein.

In some embodiments, step 130 controls the two first reagent needles of the first reagent dispensing part to move linearly between the first reagent suction position and the reagent adding position of the reaction part independently of each other. In this way, the two first reagent needles of the first reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the first reagent to the reaction cup on the transposition in the reagent addition of the reaction part, which improves the test speed And efficiency. In some specific embodiments, step 130 controls each first reagent needle in the first reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the first reagent, and the gap between the two first reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles of the first reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two first reagent needles can be arranged. The action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device. It should be noted that multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between the two first reagent needles, at least one of the four actions does not overlap in time sequence.

Step 130 completes adding the first reagent to the reaction cup with the sample.

Step 140, that is, the incubation step, the control scheduling component schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measurement component for indexing. In step 140, the transposition in the reagent addition of the measurement component may be the transposition in the measurement mentioned herein.

Step 150, that is, the second reagent dispensing step, control the rotation of the reagent carrying part so that the reagent container carrying the second reagent is located at the second reagent suction position; control at least one of the two reagent needles on the second reagent dispensing part A second reagent in the reagent container is sucked through the second reagent suction position, and a linear motion is made between the second reagent suction position and the indexing position of the reagent adding of the measuring part, so as to divide the reaction cup indexed into the reagent adding of the measuring part. Inject the second reagent.

In some embodiments, step 150 controls the two second reagent needles of the second reagent dispensing part to move linearly between the second reagent suction position and the reagent adding position of the measuring part independently of each other. In this way, the two second reagent needles of the second reagent dispensing part can be separately and independently-for example, alternately completing the operation of adding the second reagent to the reaction cup on the transposition in the reagent addition of the measuring part, which improves the test speed And efficiency. In some specific embodiments, step 150 controls each second reagent needle in the second reagent dispensing part to perform multiple preset actions in sequence to complete the operation of adding the second reagent, and the gap between the second reagent needles Among the multiple preset actions, at least one corresponding preset action does not overlap in time sequence. In this case, the two reagent needles of the second reagent dispensing part can avoid occupying public resources as little as possible, so that the number of parts that provide corresponding public resources can be reduced, so that the sample analysis device can be more compact; and in this way, two second reagent needles can be arranged. The action timing of the reagent needles also try to avoid their mutual influence, which is very beneficial to the speed-up of the sample analysis device. It should be noted that multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: a reagent sucking action, a heating action, a reagent discharging action, and a cleaning action. Between two second reagent needles, at least one of the four actions does not overlap in time sequence.

Step 150 is completed to continue adding the second reagent to the reaction cup carrying the reagent after the incubation.

Step 160, that is, the measurement and recovery step, the control and scheduling component will dispatch the reaction cup that has completed the dispensing of the second reagent to the measurement component for item detection, and dispatch the completed reaction cup to the waste recovery device-the waste recovery device can It has, for example, the second tossing position mentioned in this article.

The above is an overall process of the work of the sample analysis device.

The work flow arrangement of the reagent dispensing component 60 puts forward important constraints on the completion of the detection speed, and each reagent needle needs to complete actions such as sample aspiration, heating, layout, and cleaning. The reagent carrying member 40 is used to ensure the activity of the reagent, and the temperature is generally lower, for example, below 16°C. After the reagent is taken out from the reagent carrying member 40, it needs to be heated in the reagent needle to about 37° C. in a short time to ensure a sufficient reaction process. Normally, the heating time of the reagent drawn by the reagent needle by the heating part of the reagent needle requires 4-10 seconds. The reagent needle needs to absorb different types of reagents in the detection process of different test items. For example, in the four routine coagulation (PT/APTT/TT/FIB) test items, different second reagents need to be taken in turn from the reagent carrying part 40 That is, the trigger reagent is added to the reaction cup to react. Therefore, the same reagent needle needs to be cleaned by ordinary cleaning or strong cleaning when sucking reagents from different items. In order to ensure the cleaning effect and avoid the contamination between the reagents that affects the accuracy of the test results, the cleaning time generally takes 2 to 8 seconds. The sample suction and layout actions generally take 1.5 to 3 seconds (including the time for the horizontal movement to reach the position). Therefore, for a sample analysis device, for example, a single working cycle is 8 seconds, and it is difficult to complete all the actions of aspirating, heating, setting out, and cleaning in one working cycle, and the overall detection speed is nearly reduced.

In some embodiments of the present invention, how to add reagents to the sample analysis device, that is, how to arrange the action timing of each reagent needle, is designed, which will be described in detail below.

In some embodiments, the processor 90 is used to control each reagent needle in the same group to perform multiple preset actions in sequence, such as a reagent suction action, a reagent heating action in the reagent needle, a reagent discharge action, and a reagent needle cleaning action to complete Reagent adding operation, and at least one corresponding preset action among the multiple preset actions between two reagent needles in the same group does not overlap in time sequence. For example, the first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles, and at least one of the corresponding preset actions between the two first reagent needles does not overlap in time sequence. The second set of reagent needles in the reagent dispensing component 60 includes two second reagent needles, and at least one corresponding preset action between the two second reagent needles does not overlap in time sequence. In some embodiments, the ping-pong mode may be set for the sample analysis device. When this mode is enabled, the processor 90 executes the ping-pong mode, so that at least one corresponding action between two reagent needles in each group of reagent needles is in time sequence. No overlap, for example, in the same group of reagent needles, at least one corresponding action does not overlap in time sequence of the reagent sucking action, the reagent heating action in the reagent needle, the reagent discharging action, and the reagent needle cleaning action. The corresponding actions include a reagent sucking action and/or a reagent needle cleaning action. In some other embodiments, for all reagent needles (including the first reagent needle and the second reagent needle) that perform reagent dispensing in the sample analysis device, the processor will control each reagent to perform multiple preset actions in sequence to complete Reagent adding operation, and at least one corresponding preset action among the plurality of preset actions between two reagent needles does not overlap in time sequence. For example, the first reagent needle includes a first reagent needle a1 and a first reagent needle a2, and the second reagent needle includes a second reagent needle b1 and a second reagent needle b2. When the processor controls the first reagent needle a1, the first reagent needle a2, the second reagent needle b1, and the second reagent needle b2 to each complete multiple preset actions, at least one corresponding preset action does not overlap in time sequence. The processor arranges all the reagent needles in the sample analysis device in time sequence to prevent the actions of the reagent needles from interfering with each other to grab resources, thereby more effectively using shared resources and improving the sample testing efficiency of the sample analysis device.

In some embodiments, the aforementioned multiple preset actions may include a first type of preset action and a second type of preset action. The first type of preset action is the action that each reagent needle needs to interact with the same component. Generally, the first type of preset action can be some actions that the reagent needle needs to occupy public resources, such as the action of sucking reagent-which needs to occupy the reagent load. The common part of the component 40, such as the reagent needle cleaning action, needs to occupy a pipeline for providing the cleaning liquid for each cleaning tank 81; therefore, the first type of preset actions include at least a reagent suction action and a reagent needle cleaning action. The second type of preset actions are actions in which each reagent does not need to interact with the same component. Generally, the second type of preset actions can be actions that do not require common resources for reagent needles, such as reagent heating actions-each reagent needle Each heating component heats the sucked reagent; therefore, the second type of preset action includes at least the heating action of the reagent in the reagent needle. In some embodiments, the first type of preset actions corresponding to the two reagent needles in the same group do not overlap in time sequence, for example, the reagent sucking action between two reagent needles in the same group does not overlap in time sequence. The cleaning action of the reagent needle does not overlap in time sequence. For example, Figure 18 is an example.

In some embodiments, each corresponding preset action in the plurality of preset actions between two reagent needles in the same group does not overlap in time sequence. For example, Figure 19 is an example. The first group of reagent needles in the first reagent dispensing part 60 includes two first reagent needles. The reagent suction action between the two first reagent needles does not overlap in time sequence, and the reagent heating action in the reagent needle is in time sequence. No overlap, the sequence of the ejection of reagents does not overlap, and the sequence of the reagent needle cleaning action does not overlap the reagent sucking action; for another example, the second group of reagent needles in the second reagent dispensing part 60 includes two second reagents. Needle, the reagent suction action between the two second reagent needles does not overlap in time sequence, the reagent heating action in the reagent needle does not overlap in time sequence, the reagent ejection action does not overlap in time sequence, and the reagent needle cleaning action sucks The reagent actions do not overlap in timing.

In some embodiments, when the sample analysis device completes a fixed test volume, the time interval between two adjacent and identical test items outputting results is defined as a cycle, and the number of reagent needles set in each reagent dispensing component is equal to that of one reagent needle. The number of cycles occupied by multiple preset actions is equal. For example, the number of cycles occupied by one reagent needle to complete the above-mentioned multiple preset actions (for example, reagent suction action, reagent heating action in the reagent needle, reagent discharge action, and reagent needle cleaning action) is two, then two reagent dispensing components are set One reagent needle, or the number of reagent needles in the same group is two. From another perspective, in some embodiments, the processor 90 controls each reagent needle of the reagent dispensing component to complete the multiple preset actions within a preset time (for example, a reagent sucking action, a reagent heating action in the reagent needle, Reagent discharging action and reagent needle cleaning action), the preset time is equal to N times the period, and N is equal to the number of reagent needles of the reagent dispensing part. For example, if the number of reagent needles in each reagent dispensing part 60 is two, then N is equal to two. Each reagent needle needs to complete the multiple preset actions (for example, reagent sucking action, reagent needle Reagent heating action, reagent discharge action and reagent needle cleaning action). By setting the number of reagent needles of the reagent dispensing part and the cycle for completing the multiple preset actions in this way, the test speed of the sample analysis device can be equivalent to that each reagent needle completes the multiple in one cycle. Preset actions (such as sucking reagent, heating reagent in the reagent needle, discharging reagent, and cleaning reagent needle) ensure a constant output speed of the sample analysis device. There is a preset time mentioned here. In some embodiments, when the time it takes for the reagent needle to perform multiple preset actions is less than the preset time, in order to further ensure that the sample analysis device outputs the detection result at a constant speed, the reagent needle will wait , So that the waiting time plus the time spent to complete multiple preset actions add up to the preset time. In order to be able to explain more clearly, the preset time includes action time and waiting time, where the action time is used to perform the above-mentioned preset actions (for example, the action of sucking reagent, the action of heating the reagent in the reagent needle, the action of discharging the reagent, and the action of cleaning the reagent needle) The action time is less than or equal to the preset time. In some embodiments, the waiting time is divided into one or more periods of time, and is inserted between the plurality of preset actions and/or after the last preset action in time sequence—for example, it is inserted in time sequence Between the reagent suction action, the reagent heating action in the reagent needle, the reagent discharging action and the reagent needle cleaning action and/or after the reagent needle cleaning action; for example, FIG. 20 is an example. In some embodiments, the waiting time is divided into one or more periods, and at least one period in the sequence is used as an additional action time for performing a preset action. In this way, the preset action can have extra time to continue to execute. Under the constraint of the preset time, the execution time of the preset action is prolonged, which can make the reagent needle have more stable performance, such as the action of sucking reagent and The execution time of the reagent ejection action has been prolonged, which can make the reagent needle suck and eject the reagent more stably, and it is not easy to cause abnormal conditions such as empty suction or collision with the reaction cup. For example, the execution time of the reagent heating action in the reagent needle is reduced The extension can make the reagents in the reagents be fully preheated; for another example, the execution time of the reagent needle cleaning action is prolonged, which can make the reagent needles cleaned more fully, and it is not easy to cause cross-contamination of the next test item. Improve the accuracy of test results. Therefore, in some embodiments, the sample analysis device may include a full heating mode. When the full heating mode is activated, the processor 90 executes the full heating mode so that the waiting time is divided into one or more periods, and At least one period in the sequence is used as an additional action time for executing the reagent heating action in the reagent needle. For example, Figure 21 is an example.

What needs to be said is that in Figures 18-21, in order to facilitate the drawing, the heating action in the figure refers to the heating action of the reagent in the reagent needle in this article, and the cleaning action refers to the cleaning action of the reagent needle in this article; Figures 18 to 21 are drawn The two reagent needles refer to the two reagent needles in the same group, for example, the two first reagent needles in the first group of reagent needles, or the two second reagent needles in the second group of reagent needles.

In the present invention, the action sequence of the reagent needle is designed. The introduced reagent dispensing component has, for example, two reagent needles arranged in parallel. The double reagent needles running independently and linearly are scheduled through ping-pong, and the extended cycle completes reagent suction, preheating, and reagent discharge. The entire workflow of cleaning and cleaning provides double resources to ensure speed increase, so as to achieve the goal of no slowdown in testing of multiple inspection items.

The following describes how the reaction cups are scheduled by the scheduling component 70. In some embodiments, the present invention uses three transfer components and two buffer transfers to transfer the cuvette.

Some embodiments of the present invention also disclose a method of a sample analysis device. Please refer to FIG. 22. The method may include the following steps:

In step 200, the first transfer component is controlled to transport the reaction cup after sample addition to the first buffer for transposition. In some embodiments, step 200 controls the first transport component to move linearly in the first direction, and transport the reaction cup after sample addition to the first buffer for indexing.

Step 210: Control the second transport component to transport the transposed cuvette in the first buffer to the incubation position. The incubation position here may be a reaction cup placement position in the reaction component 51. In some embodiments, step 210 controls the second transport member to transport the transposed cuvette in the first buffer to the incubation position through linear movement in the first direction and linear movement in the second direction.

In step 220, the second transport component is controlled to transport the reaction cup that has completed the sample incubation in the incubation position to the second buffer for transposition.

In some embodiments, step 220 controls the second transport component to transport the reaction cups completed with the sample in the incubation position to the second buffer for transposition through linear motion in the first direction and linear motion in the second direction. In some specific embodiments, step 220 controls the second transport component to first transport the cuvettes transposed in the first buffer to the incubation for adding reagents, and then transport the cuvettes translocated and added reagents during the incubation to the incubation. Bit.

In some specific embodiments, in step 220, during the transposition and transportation of the reaction cup from the incubation to the incubation position, the second transfer component is controlled to mix the sample in the reaction cup. When the second transfer component transfers the reaction cup, the second transfer component is also controlled to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.

Step 230: Control the third transport component to transport the indexed cuvette in the second buffer to the measurement position.

In some embodiments, step 230 controls the third transport component to transport the indexed cuvette in the second buffer to the measurement position through linear movement in the first direction and linear movement in the second direction. In some specific embodiments, step 230 controls the second transport component to first transport the cuvettes indexed in the second buffer to the assay for adding reagents, and then transport the cuvettes after the indexing and adding reagents during the assay to the assay. Bit.

In some specific embodiments, step 230 controls the third transfer component to mix the sample in the reaction cup during the transposition and transportation of the reaction cup from the second buffer to the measurement position. When the third transfer component transfers the reaction cup, it also controls the third transfer component to mix the sample in the reaction cup, which saves time, and there is no need to schedule the reaction cup to the corresponding mixing mechanism for mixing.

The three transport components move along a straight line to realize the rapid transport of the reaction cup. With two buffers, the scheduling path of the reaction cup is simple and direct, which is beneficial to the speed-up of the sample analysis device.

Finally, take the sample analysis device including a first reagent dispensing part 60 having two first reagent needles 61, a second reagent dispensing part 60 having two second reagent needles 61, a reaction part 51, and a measurement part 52 as an example. ，Combine a specific test item to illustrate the present invention.

The reaction component 51 has a certain number of reaction cup placement positions, and can heat the sample in the reaction cup located on the reaction cup placement position to incubate the sample. According to different test items, some test items may need to add a first reagent, such as a mixed reagent. For example, when testing the measurement item APTT based on the coagulation method, the first reagent dispensing part 60 sucks the first reagent, for example, mixed reagents, from the reagent carrying part 40, and discharges the sucked first reagent into the reaction part 51 In the incubation, the reaction cup of 51a is transposed to complete the mixing of the first reagent and the sample. After completing the addition of the mixed reagents, the second transfer part 73 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the reaction part 51, and the reaction part 51 incubates the reaction solution or sample in the reaction cup .

The reagent carrying member 40 is to ensure the activity of the reagent, so the working temperature is usually low, for example, usually below 16°C. In order to ensure that the coagulation reaction process is sufficient and obtain accurate test results, the first reagent needs to be heated to about 37°C before being added to the reaction cup and mixed with the sample. In order to increase the test speed of the sample analysis device, it is necessary to complete the heating of the first reagent in a relatively short time. Therefore, the two first reagent needles 61 of the first reagent dispensing part 60 have heating parts for completing the reagent heating function . Normally, the heating time for the reagents requires 4-10 seconds. For high-speed sample analysis devices, the single working cycle is, for example, 8 seconds. In this case, the heating time for the reagents will take a long time, which is important for upgrading the sample analysis device. The test speed has a great impact. Therefore, in some embodiments of the present invention, the first reagent dispensing part 60 has two first reagent needles 61, and the two first reagent needles 61 respectively suck the first reagent, such as mixed reagent, from the reagent carrying part 40, and are fixed in The linear guide on the linear beam moves to the incubation position 51a, and the first reagent, such as mixed reagent, is added to the reaction cup in turn. The two first reagent needles 61 are arranged in parallel and move independently. Since there are two independent first reagent needles 61, the working cycle time of the first reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the first reagent. Make the reagent temperature stably reach 37°C.

After the sample in the reaction cup is heated and incubated in the reaction part 51 for a fixed period of time, the reaction cup is transferred to the measurement part 52 through the cooperation of the second transfer part 73 and the third transfer part 75. In some embodiments, the measurement can be carried out on the way. The intermediate position 52a is used to add a second reagent such as a trigger reagent.

The third transfer part 75 transfers the cuvette to the measuring transposition 52a, and the second reagent dispensing part 60 sucks the second reagent, such as the trigger reagent, from the reagent carrying part 40, and moves it to the cuvette gripped by the third transfer part 75. Above, a second reagent such as a trigger reagent is added to the reaction cup to complete the mixing of the second reagent and the sample. After completing the addition of the trigger reagent, the third transfer component 75 can mix the reaction solution in the reaction cup uniformly, and then place the reaction cup in the measurement component 52 to perform coagulation signal analysis and detection to obtain the detection result.

Similar to the first reagent dispensing part 60, in order to ensure sufficient heating time for the second reagent, such as the trigger reagent, the second reagent dispensing part 60 also has two reagent needles, such as two second reagent needles; The two reagent needles respectively suck the second reagent, such as trigger reagent, from the reagent carrying member 40, move to the measuring index 52a through the linear guide rail fixed on the linear beam, and add the second reagent, such as trigger reagent, to the reaction cup in turn. The two second reagent needles 61 are arranged in parallel and move independently. Since there are two independent second reagent needles 61, the working cycle time of the second reagent dispensing part 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating part of the reagent needle has sufficient heating time for the second reagent. Make the reagent temperature stably reach 37°C.

The reaction cup in the measuring part 52 is irradiated with multi-wavelength light, and the transmitted light or scattered light is received by, for example, a photodetector in the measuring part 52, and a detection signal corresponding to the amount of received light is output. The detection signal can be sent to, for example, processing The device 90 is used for data analysis, processing and generation of corresponding display content. Sample analysis devices such as automatic coagulation analyzers can use different methods such as coagulation method, immunoturbidimetric method, and chromogenic substrate method for sample analysis. Depending on the detection method, the measuring part 52 irradiates the reaction cup with different wavelengths. For light, the wavelength range can be, for example, between 405 nm and 800 nm.

The reaction cup that has completed the test can be transferred to the waste recycling device by the third transfer component 75-the waste recycling device can have, for example, the second throwing cup position mentioned herein, and the third transfer component 75 discards the reaction cup to the second throwing cup In the position, the disposal of the reaction cup is completed.

This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope of this document. For example, various operation steps and components used to perform the operation steps can be implemented in different ways according to a specific application or considering any number of cost functions associated with the operation of the system (for example, one or more steps can be deleted, Modify or incorporate into other steps).

In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. In addition, as understood by those skilled in the art, the principles herein can be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with computer-readable program code. Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD to ROM, DVD, Blu Ray disks, etc.), flash memory and/or the like . These computer program instructions can be loaded on a general-purpose computer, a special-purpose computer or other programmable data processing equipment to form a machine, so that these instructions executed on the computer or other programmable data processing equipment can generate a device that realizes the specified functions. These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing equipment to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a piece of Manufactured products, including realizing devices that realize designated functions. Computer program instructions can also be loaded on a computer or other programmable data processing equipment, so as to execute a series of operation steps on the computer or other programmable equipment to produce a computer-implemented process, so that the execution on the computer or other programmable equipment Instructions can provide steps for implementing specified functions.

Although the principles herein have been shown in various embodiments, many modifications to the structure, arrangement, proportions, elements, materials, and components that are particularly suitable for specific environments and operating requirements can be made without departing from the principles and scope of this disclosure. use. The above modifications and other changes or amendments will be included in the scope of this article.

The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of this disclosure. Therefore, the consideration of this disclosure will be in an illustrative rather than restrictive sense, and all these modifications will be included in its scope. Likewise, the advantages, other advantages, and solutions to problems of the various embodiments have been described above. However, benefits, advantages, solutions to problems, and any elements that can produce these, or make them more specific, should not be construed as critical, necessary, or necessary. The term "including" and any other variants used in this article are non-exclusive inclusions. Such a process, method, article or device that includes a list of elements not only includes these elements, but also includes those that are not explicitly listed or are not part of the process. , Methods, systems, articles or other elements of equipment. In addition, the term "coupled" and any other variations thereof used herein refer to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection and/or any other connection.

Those skilled in the art will recognize that many changes can be made to the details of the above-described embodiments without departing from the basic principles of the present invention. Therefore, the scope of the present invention should only be determined by the claims.

Claims

A sample analysis device, characterized in that it comprises:

chassis;

The reaction cup loading parts are used to supply and carry empty reaction cups;

Sampling component, used to dispatch the sample rack carrying the sample to the sample suction position;

The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;

A reagent carrying part, which is arranged in a disc-shaped structure, has a plurality of positions for carrying the first reagent container of the first reagent, and has a plurality of positions for carrying the second reagent container of the second reagent Position; the reagent carrying member includes a first driving assembly for driving its rotation, the first driving assembly drives the reagent carrying member to rotate and drives the first reagent container to rotate, so as to rotate the first reagent container to the first Reagent suction position; the first drive assembly drives the reagent carrying member to rotate and drives the second reagent container to rotate, so as to rotate the second reagent container to the second reagent suction position;

The reaction part is used to carry the reaction cup and incubate the sample in the reaction cup, and the reaction part is configured with at least one position for placing the reaction cup during incubation;

The measuring component is used to carry the reaction cup and detect the sample in the reaction cup, and the measuring component is configured with at least one mid-measurement index for placing the position of the reaction cup;

The first reagent dispensing component includes: a first beam and a first group of reagent needles, the first group of reagent needles includes at least a plurality of first reagent needles; the plurality of first reagent needles are arranged on the first beam, And move linearly along the long axis of the first beam, so as to suck the first reagent from the first reagent suction position and discharge it into the reaction cup positioned in the incubation;

The second reagent dispensing component includes: a second beam and a second group of reagent needles, the second group of reagent needles includes at least a plurality of second reagent needles; the plurality of second reagent needles are arranged on the second beam, And move linearly along the long axis direction of the second beam to suck the second reagent from the second reagent suction position and discharge it into the reaction cup that is positioned in the middle of the measurement;

The scheduling component is used to schedule the reaction cups; the scheduling component schedules the reaction cup with the first reagent added on the index during the incubation to the reaction part, and schedules the reaction cup with the second reagent added on the index during the measurement to the measurement part.
The sample analysis device of claim 1, wherein:

The first beam is arranged along the direction determined by the first reagent suction position and the incubation index, and the first beam is fixedly arranged above the first reagent suction position and the incubation index corresponding to position;

The second beam is arranged along the direction determined by the second reagent suction position and the indexing position in the measurement, and the second beam is fixedly arranged above the second reagent suction position and the indexing position corresponding to the measurement. position.
The sample analysis device according to claim 1 or 2, wherein:

The first crossbeam of the first reagent dispensing component is set as one, and a plurality of the first reagent needles are arranged on the first crossbeam in parallel and move linearly along the long axis direction of the first crossbeam;

The second crossbeam of the second reagent dispensing component is set as one, and a plurality of second reagent needles are arranged on the second crossbeam in parallel and move linearly along the long axis direction of the second crossbeam.
The sample analysis device of claim 3, wherein the first reagent needles of the first group of reagent needles are provided with two, and the second reagent needles of the second group of reagent needles are provided with two;

A linear guide rail is respectively provided on both sides of the first beam along its long axis, and the two first reagent needles are respectively provided on the linear guide rails on both sides of the first beam. The linear guide rail on which it is located moves linearly between the first reagent suction position and the transposition during the incubation;

A linear guide rail is respectively provided on both sides of the second cross beam along its long axis, and two second reagent needles are respectively provided on the linear guide rails on both sides of the second cross beam. The linear guide rail on which it is located performs linear motion between the second reagent suction position and the mid-measurement indexing position.
The sample analysis device according to claim 1 or 2, wherein:

The number of the first beams of the first reagent dispensing part is equal to the number of the first reagent needles of the first group of reagent needles, each of the first beams is provided with a first reagent needle, and there are two The first beams are arranged parallel to each other;

The number of the second beams of the second reagent dispensing part is the same as the number of the second reagent needles of the second group of reagent needles, and each of the second beams is provided with a second reagent needle. The second beams are arranged parallel to each other.
The sample analysis device of claim 5, wherein:

The multiple first beams are each provided with a linear guide along their long axis, and the multiple first reagent needles are respectively provided on the linear guides of the multiple first beams for the first reagent needles to transfer at the first reagent suction position and incubation. Straight line movement between positions;

Each of the plurality of second beams is provided with a linear guide along its long axis, and a plurality of second reagent needles are respectively provided on the linear guides of the plurality of second beams for the second reagent needles to be transferred at the second reagent suction position and incubation. Perform linear movement between positions.
The sample analysis device according to any one of claims 1 to 6, wherein:

The first reagent dispensing component further includes a plurality of second driving components that independently drive the plurality of first reagent needles to move linearly, and the number of the plurality of second driving components is equal to the number of the first reagent needles. The independent driving force output ends of each of the second driving components act on a plurality of the first reagent needles to drive the plurality of first reagent needles in the first suction along the long axis direction of the first beam. Linear movement between the reagent position and the transposition during the incubation;

The second reagent dispensing component further includes a plurality of third driving components that are different from the second driving components and independently drive a plurality of second reagent needles to move linearly. The number of the third driving components is greater than the number of The number of the second reagent needles is equal, and the independent driving force output ends of the plurality of third driving components respectively act on the plurality of second reagent needles to drive the plurality of second reagent needles along the second beam The direction of the long axis of the tube moves linearly between the second reagent suction position and the indexing position in the measurement.
The sample analysis device according to any one of claims 1 to 7, wherein the sample injection component, the reaction cup loading component, the reaction component and the measurement component are arranged around the reagent carrying component.
The sample analysis device according to any one of claims 1 to 8, wherein the reaction part and the measurement part are arranged adjacent to the reagent carrying part.
The sample analysis device according to any one of claims 1 to 9, wherein the incubation index is arranged between the reagent carrying part and the reaction part; the measuring index is arranged in the reagent carrying part And the measurement part.
The sample analysis device according to any one of claims 8 to 10, wherein the reaction part is rectangular and has a plurality of reaction cup placement positions; the measurement part is rectangular and has a plurality of reaction cups Place a bit.
11. The sample analysis device according to claim 11, wherein the length direction of the reaction part is arranged along a first direction, and the length direction of the measuring part is arranged along a second direction different from the first direction.
The sample analysis device according to any one of claims 1 to 12, wherein:

The linear motion trajectory of the plurality of first reagent needles of the first reagent dispensing part between the first reagent suction position and the incubation position is a first motion trajectory;

The trajectory of the linear motion of the plurality of second reagent needles of the second reagent dispensing component between the second reagent suction position and the indexing position during the measurement is a second motion trajectory;

Wherein, the first movement trajectory and the second movement trajectory do not cross.
The sample analysis device according to any one of claims 1 to 13, wherein the number of first reagent needles of the first group of reagent needles is two; the number of second reagent needles of the second group of reagent needles is two .
The sample analysis device of claim 14, wherein:

The transposition during the incubation includes a first position and a second position for placing the reaction cup, the first reagent needle moves linearly along the first beam between the first reagent suction position and the first position, and the other The first reagent needle moves linearly along the first beam between the first reagent suction position and the second position;

The transposition in the measurement includes a third position and a fourth position for placing the reaction cup. One the second reagent needle moves linearly between the second reagent suction position and the third position along the second beam, and the other The second reagent needle moves linearly along the second beam between the second reagent suction position and the fourth position.
The sample analysis device according to any one of claims 1 to 15, wherein the first reagent needle and/or the second reagent needle is provided with a heating component for heating the sucked reagent .
The sample analysis device according to any one of claims 1 to 16, wherein the first reagent dispensing component further comprises a first reagent needle for driving the first reagent needles in the first group of reagent needles to move in the vertical direction. The first Z-direction drive assembly moving upward, the number of the first Z-direction drive assembly is the same as the number of the first reagent needles in the first group of reagent needles; the first Z-direction drive assembly includes: for guiding the first reagent needle A first Z-direction member that moves in the vertical direction, and a first Z-direction driving member for driving the first reagent needle to move along the first Z-direction member; the first reagent needle passes through the first Z direction The first Z-direction drive member and the first Z-direction drive member form a sliding connection with the first beam, so that the first reagent needle can move in the vertical direction relative to the first beam under the drive of the first Z-direction drive member;

The second reagent dispensing component also includes a second Z-direction drive assembly for driving the second reagent needles in the second group of reagent needles to move in the vertical direction. The number of the second Z-direction drive assemblies is greater than that of the second Z-direction drive assembly. The number of the second reagent needles in the group of reagent needles is the same; the second Z-direction drive components all include: a second Z-direction guide for guiding the second reagent needle to move in the vertical direction, and a second Z-direction guide for driving the second reagent The second Z-direction driving member that the needle moves along the second Z-direction member; the second reagent needle forms a sliding connection with the second crossbeam through the second Z-direction member and the second Z-direction driving member, so that the second reagent needle It can move in the vertical direction relative to the second crossbeam under the drive of the second Z-direction driving member.
A sample analysis device, characterized in that it comprises:

The reaction cup loading parts are used to supply and carry empty reaction cups;

Sampling component, used to dispatch the sample rack carrying the sample to the sample suction position;

The sample dispensing component is used to aspirate the sample from the sample suction position and discharge it into the reaction cup at the sample addition position;

The reagent carrying part is used to rotate the reagent carrying part, and is used to rotate the reagent container to the reagent suction position;

One or more processing units; the processing unit is used to receive a reaction cup carrying a sample and process the sample in the reaction cup; wherein each processing unit is configured with a corresponding reagent addition intermediate transposition;

One or more reagent dispensing components, the number of reagent dispensing components is equal to the number of processing units, and one reagent dispensing component corresponds to a processing unit; each reagent dispensing component includes: multiple reagent needles, A guide assembly that guides a plurality of the reagent needles for linear movement, and a second drive assembly that drives a plurality of reagent needles to move linearly along the guide assembly; the guide assembly is along the reagent suction position and the corresponding reagent dispensing part The direction determined by the transposition in the reagent addition of the processing unit is set, so that the reagent needle sucks the reagent from the reagent suction position and discharges it into the reagent-adding reaction cup of the processing unit corresponding to the reagent dispensing component; and

The scheduling component is used to schedule the reaction cups located in the sample loading position to complete the sample addition to each processing unit according to the detection flow.
The sample analysis device according to claim 18, wherein the guide assembly of each reagent dispensing part comprises: a cross beam, and a plurality of guides arranged in parallel along the length direction of the cross beam; The cross beam is arranged along the direction determined by the transposition of the reagent suction position and the processing unit corresponding to the reagent dispensing part; the number of guides is equal to the number of reagent needles of the reagent dispensing part, and multiple reagent needles are connected to multiple guides respectively The parts are slidably connected, so that the reagent needle moves linearly along the guide part between the reagent sucking position and the reagent adding position.
The sample analysis device according to claim 18, wherein the guide assembly of each reagent dispensing part comprises: a plurality of beams arranged in parallel, and a plurality of beams respectively arranged on the plurality of beams and along the beams Guides arranged in the length direction; a plurality of the beams are arranged along the direction determined by the transposition of the reagent suction position and the processing unit corresponding to the reagent dispensing part; the number of guides is equal to the number of reagent needles of the reagent dispensing part , And a plurality of reagent needles are respectively slidably connected with a plurality of guide members, so that the reagent needle moves linearly along the guide member between the reagent suction position and the reagent adding position.
The sample analysis device according to claim 19 or 20, wherein the beam of the guide assembly in each reagent dispensing part is fixedly arranged at the reagent suction position and the transposition in the reagent adding position of the processing unit corresponding to the reagent dispensing part Position above.
The sample analysis device according to claim 19, wherein each reagent dispensing part has two reagent needles; each reagent dispensing part has two guides, and two guides All linear guides;

Two linear guide rails are respectively arranged on both sides of the beam along the long axis direction of the beam; the two reagent needles are respectively arranged on the linear guide rails on both sides of the beam and are slidably connected with the linear guide; The linear guide rail moves in a linear motion between the reagent suction position and the indexing position during reagent addition.
The sample analysis device according to claim 20, wherein the plurality of guides of each reagent dispensing part are linear guides, and the plurality of linear guides are respectively arranged along the long axis direction of the plurality of beams; and the plurality of reagent needles They are respectively arranged on the linear guide rails of a plurality of beams and slidably connected with the linear guide rail; the reagent needle moves linearly between the reagent suction position and the transposition during reagent addition along the linear guide rail where it is located.
The sample analysis device according to any one of claims 18 to 23, wherein the number of second drive components of each reagent dispensing part is equal to the number of reagent needles, and the plurality of second drive components are independent The driving force output end correspondingly acts on the multiple reagent needles to independently drive the multiple reagent needles to move linearly between the reagent suction position and the reagent adding position along the guide assembly.
The sample analysis device according to any one of claims 18 to 24, wherein the trajectories of the reagent needles of different reagent dispensing parts do not cross each other along the linear movement.
The sample analysis device according to any one of claims 18 to 25, wherein the reagent needles in the same reagent dispensing part are used to suck the same type of reagent.
The sample analysis device according to any one of claims 18 to 26, wherein the transposition of at least one of the processing units for adding reagents includes the same number of reagent needles of the reagent dispensing part corresponding to the processing unit. Place the reaction cup.
The sample analysis device according to any one of claims 18 to 27, wherein each reagent needle is provided with a heating component for heating the aspirated reagent in the reagent needle.
The sample analysis device according to any one of claims 18 to 28, wherein at least one of the processing units is a reaction part for incubating a sample.
The sample analysis device according to any one of claims 18 to 29, wherein at least one of the processing units is a measuring part for measuring a sample.
The sample analysis device according to any one of claims 18 to 30, wherein the number of the reagent suction positions is the same as the number of reagent needles.
A sample analysis method is characterized in that it comprises the following steps:

Reaction cup loading step, controlling the supply of reaction cup loading parts and carrying empty reaction cups;

In the sample feeding step, the sample feeding component is controlled to dispatch the sample rack carrying the sample to the sample suction position;

In the sample dispensing step, control the sample dispensing component to aspirate the sample from the sample suction position and dispense it into the reaction cup;

In the first reagent dispensing step, the driving part is controlled to drive the reagent carrying part to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position; at least one of the two reagent needles on the first reagent dispensing part is controlled The first reagent in the reagent container is sucked through the first reagent sucking position, and a linear movement is made between the first reagent sucking position and the indexing of the reagent adding of the reaction part to index the reagents of the reaction part Dispense the first reagent into the reaction cup;

In the incubation step, the control scheduling component schedules the reaction cup that has completed the dispensing of the first reagent to the reaction component for incubation, and schedules the reaction cup after the incubation is completed to the reagent addition of the measurement component for transposition;

In the second reagent dispensing step, the reagent carrying part is controlled to rotate so that the reagent container carrying the second reagent is located at the second reagent suction position; at least one of the two reagent needles on the second reagent dispensing part is controlled to pass through the The second reagent sucking position sucks the second reagent in the reagent container, and moves linearly between the second reagent sucking position and the indexing of the reagent adding of the measuring part to transfer the reaction cup into the reagent adding of the measuring part Dispense the second reagent;

In the measurement and recovery step, the control and scheduling component dispatches the reaction cup that has completed the dispensing of the second reagent to the measurement component for item detection, and dispatches the reaction cup after the detection to the waste recovery device.
The method of claim 32, wherein the step of dispensing the first reagent further comprises:

The two first reagent needles that control the first reagent dispensing part independently move linearly between the first reagent sucking position and the reagent adding position of the reaction part.
The method according to claim 32 or 33, wherein the second reagent dispensing step further comprises:

The two second reagent needles that control the second reagent dispensing component independently move linearly between the second reagent suction position and the reagent adding position of the measuring component.
The method according to any one of claims 32 to 34, wherein the first reagent dispensing step further comprises:

Each first reagent needle in the first reagent dispensing part is controlled to perform multiple preset actions in sequence to complete the operation of adding the first reagent, and among the multiple preset actions between two first reagent needles, At least one corresponding preset action does not overlap in timing.
The method according to any one of claims 32 to 35, wherein the second reagent dispensing step further comprises:

Each second reagent needle in the second reagent dispensing component is controlled to perform multiple preset actions in sequence to complete the second reagent addition operation, and among the multiple preset actions between two second reagent needles, At least one corresponding preset action does not overlap in timing.