CN107252793A - A kind of analyzer disc type cleaning device - Google Patents
A kind of analyzer disc type cleaning device Download PDFInfo
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- CN107252793A CN107252793A CN201710498780.0A CN201710498780A CN107252793A CN 107252793 A CN107252793 A CN 107252793A CN 201710498780 A CN201710498780 A CN 201710498780A CN 107252793 A CN107252793 A CN 107252793A
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- reaction cup
- imbibition
- cup
- magnetic pole
- cleaning device
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to a kind of analyzer disc type cleaning device, magnetic bead in reaction cup is attracted by the pole pair positioned at some reaction cup run channel both sides, make magnetic bead be located at reaction cup front and rear wall on so that will not siphon away the magnetic bead in reaction cup when being inserted into imbibition injection needle imbibition in reaction cup.Meanwhile, by the change of each pole pair N S poles the magnetic bead in the gap reaction cup of imbibition is moved, magnetic bead is fully contacted with cleaning fluid, wash the nonadherent reagent in magnetic bead surfaces off.
Description
Technical field
The present invention relates to a kind of analyzer disc type cleaning device, belong to technical field of medical instruments.
Background technology
Chemiluminescence immune assay (chemiluminescence immunoassay, CLIA), is by with high sensitivity
Chemical luminescent detecting technology be combined with the immune response of high specific, for various antigens, haptens, antibody, hormone,
The detection and analysis technology of enzyme, aliphatic acid, vitamin and medicine etc..It is generally necessary to specific biological raw material is coated on magnetic bead,
Then luminescent solution is being added, is collecting luminous intensity to carry out quantitative analysis to detectable substance.
Analyzer disc type cleaning device is manufactured to realize continuous measurement, and reaction cup is enterprising in a disk rotated
Row is cleaned multiple times, so as to the specific biological raw material not being coated on magnetic bead be washed, existing analyzer disc type cleaning dress
Put cleaning performance bad, and magnetic bead be easily cleaned into liquid band together, so as to influence the accuracy of measurement.
The content of the invention
The technical problem to be solved in the present invention is：To overcome above mentioned problem, there is provided a kind of more preferable analyzer of cleaning performance
Disc type cleaning device.
The technical solution adopted for the present invention to solve the technical problems is：
The present invention provides a kind of analyzer disc type cleaning device, including cleaning disc mechanism, imbibition mechanism for filling liquid and rocking evenly machine
Structure；
The cleaning disc mechanism includes：
Cylinder, with circular reaction cup run channel；
Disk, is rotatably arranged in cylinder, and isometrical on disk to be placed with a circle reaction cup receiving hole, reaction cup can
Insert in reaction cup receiving hole；
Some magnetic pole groups, are arranged in cylinder and are sequentially arranged along reaction cup traffic direction, are located at if each magnetic pole group has
The pole pair of dry reaction cup run channel both sides is constituted, and each magnetic pole group at least has two magnetic for being located at reaction cup run channel both sides
Extremely right, the pole orientation of the magnet in addition to last magnetic pole group in each magnetic pole group in each pole pair is identical, two neighboring
The pole orientation of pole pair is on the contrary, the pole orientation of the magnet in each pole pair of last magnetic pole group is identical or different
And pole pair sets height gradually to reduce；
The imbibition injection needle of imbibition mechanism for filling liquid can be extend into when needing imbibition and fluid injection each magnetic pole group last
In reaction cup on the corresponding position of individual pole pair；
The uniform shaking mechanism is located between two magnetic pole groups.
Preferably, in analyzer disc type cleaning device of the invention, last magnetic pole group latter pole pair with it is previous
Individual pole pair declines 5-8mm compared to height.
Preferably, analyzer disc type cleaning device of the invention, uniform shaking mechanism includes：Actuator is lifted, lifter plate is fixed
Actuator is shaken up in bottom of cylinder, by shaft coupling with shaking up the rocking bar that actuator is connected, the bias at the top of rocking bar is arranged on
Cup, is fixed on the flexure strip extending at the top of disk on cylinder, flexure strip and is provided with for covering the lid at the top of reaction cup
Wheel, lid wheel bottom has the circle wheel that can extend into reaction cup, and the axis of eccentric cup and the axis of rocking bar be not conllinear, to anti-
When answering the cup to be shaken up, lifting actuator driving lifter plate rises, and shakes up actuator, rocking bar, eccentric cup and is risen with lifter plate, partially
Reaction cup jack-up is propped up the lid wheel of flexure strip by heart cup at the top of reaction cup, reaction cup is fixed, actuator is shaken up afterwards and is opened again
It is dynamic, reaction cup is rocked by eccentric cup, liquid in reaction cup is shaken up, lid wheel bottom has silastic-layer, when shaking up, shakes up
Actuator makes reaction cup rotate 8-15s to a direction with 600-1200 rpms of speed.
Preferably, the distance of analyzer disc type cleaning device of the invention, the axis of eccentric cup and the axis of rocking bar
For the 1/4-1/5 of reaction cup width
Preferably, before analyzer disc type cleaning device of the invention, analyzer disc type cleaning device, last magnetic pole group
The eccentric cup of uniform shaking mechanism be magnetic, magnetic pole is located at top and bottom ends.
Preferably, analyzer disc type cleaning device of the invention, the imbibition injection needle of imbibition mechanism for filling liquid can need
It is extend into when imbibition and fluid injection in the reaction cup on the corresponding position of each last pole pair of magnetic pole group, imbibition and fluid injection knot
Shu Hou, then imbibition injection needle is taken out, in addition to last root imbibition injection needle, remaining imbibition injection needle, which is respectively provided with, to be arranged in parallel
Pipette and liquid injection pipe, last root imbibition injection needle only have pipette.
The beneficial effects of the invention are as follows：The analyzer disc type cleaning device of the present invention, by being run positioned at some reaction cups
The pole pair of groove both sides attracts the magnetic bead in reaction cup, magnetic bead is located on reaction cup front and rear wall so that be inserted into it is anti-
The magnetic bead in reaction cup will not be siphoned away when answering imbibition injection needle imbibition in cup.Meanwhile, caused by the change of each pole pair N-S poles
Magnetic bead in the gap reaction cup of imbibition is moved, and magnetic bead is fully contacted with cleaning fluid, wash off it is nonadherent
The reagent of magnetic bead surfaces.
Brief description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is a kind of three-dimensional structure diagram of embodiment of analyzer reagent cleaning device of the present invention；
Fig. 2 is the schematic diagram of disk upper magnetic pole arrangement of the present invention；
Fig. 3 is a kind of three-dimensional structure diagram of embodiment of present invention cleaning disc mechanism；
Fig. 4 is a kind of three-dimensional structure diagram of embodiment of uniform shaking mechanism of the present invention.
Reference is：
1- cylinders；11- reaction cup run channel；2- disks；3- uniform shaking mechanisms；310- shakes up actuator；311- rocking bars；321-
Flexure strip；322- lid wheels；330- bias cups；400- feed mechanisms；410- electromagnetic drivers；420- frames；430- oscillating decks；
500- cutting agencies；900- reaction cups.
Embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These accompanying drawings are simplified schematic diagram, only with
Illustration illustrates the basic structure of the present invention, therefore it only shows the composition relevant with the present invention.
Embodiment 1
The present embodiment provides a kind of analyzer disc type cleaning device, as shown in Figure 1：
Clean disc mechanism, imbibition mechanism for filling liquid and uniform shaking mechanism 3；
Cleaning disc mechanism includes：
Cylinder 1, with circular reaction cup run channel 11；
Disk 2, is rotatably arranged in cylinder 1, isometrical on disk 2 to be placed with a circle reaction cup receiving hole, reaction cup
900 can insert in reaction cup receiving hole；
Some magnetic pole groups, being arranged on to be sequentially arranged along the traffic direction of reaction cup 900 in cylinder 1 (has 6 magnetic in such as Fig. 1
Pole group, two pole pairs are one group), each magnetic pole group has the pole pair composition positioned at some both sides of reaction cup run channel 11, often
Individual magnetic pole group at least has in two pole pairs for being located at the both sides of reaction cup run channel 11, each magnetic pole group in each pole pair
The pole orientation of magnet is identical, and conversely (such as pole pair pole orientation is followed successively by N-S, N- to the pole orientation of two neighboring pole pair
S, S-N, S-N；N-S, N-S, S-N, S-N；N-S, N-S, S-N, S-N；N-S, N-S, S-N, S-N；N-S, N-S, S-N, S-N；N-
S, N-S, S-N, S-N), the pole pair of last magnetic pole group sets height gradually to reduce, latter pole pair and previous magnetic
Extremely to declining 5-8mm compared to height；
Uniform shaking mechanism 3, between two magnetic pole groups, including：Actuator is lifted, lifter plate is fixed on the bottom of cylinder 110
Shake up actuator 310, by shaft coupling with shaking up the rocking bar 311 that actuator 310 is connected, be arranged on the inclined of the top of rocking bar 311
Heart cup 330, is fixed on the flexure strip 321 for extending into the top of disk 120 on cylinder 110, flexure strip 321 and is provided with for covering
Lid wheel 322 at the top of reaction cup 900,322 bottoms of lid wheel have the circle wheel that can extend into reaction cup 900, eccentric cup 330
Axis is not conllinear with the axis of rocking bar 311, and the distance of the axis of eccentric cup 330 and the axis of rocking bar 311 is reaction
1/8 to the 1/4 of 900 width of cup (is 1cm than the width of reaction cup 900, then distance is 2-2.5mm, otherwise the liquid in reaction cup 900
Know from experience because shaking amplitude is big and overflows), when being shaken up to reaction cup 900, lifting actuator driving lifter plate rises, and shakes up
Actuator 310, rocking bar 311, eccentric cup 330 rise with lifter plate, and eccentric cup 330 is by the jack-up of reaction cup 900 (so that reaction cup
900 are not limited by reaction cup receiving hole 121), the top of reaction cup 900 props up the lid wheel 322 of flexure strip 321, reaction cup 900
Fix again, actuator 310 is shaken up afterwards and is started, rock reaction cup 900 by eccentric cup 330, make liquid in reaction cup 900
Shake up, 322 bottoms of lid wheel have silastic-layer, when shaking up, shake up the first reaction cup 900 of actuator 310 to a direction with 800-
1200 rpms of speed rotates 10-15s；
All magnets are neodymium ferro-boron magnet.
The eccentric cup 330 of uniform shaking mechanism 3 before last magnetic pole group has magnetic, and magnetic pole is located at top and bottom ends.
The imbibition injection needle 4 of imbibition mechanism for filling liquid can be extend into when needing imbibition and fluid injection each magnetic pole group last
In reaction cup 900 on the corresponding position of individual pole pair, after imbibition and fluid injection terminate, then imbibition injection needle 4 taken out, except last
Outside a piece imbibition injection needle 4, remaining imbibition injection needle 4 is respectively provided with the function of imbibition and fluid injection, last root imbibition injection needle 4
Only there is the function of imbibition.In addition to last root imbibition injection needle 4, remaining imbibition injection needle 4 is respectively provided with the suction be arrangeding in parallel
Liquid pipe and liquid injection pipe, last root imbibition injection needle 4 only have pipette.
The analyzer disc type cleaning device of the present embodiment, by the pole pair positioned at some both sides of reaction cup run channel 11 come
Attract the magnetic bead in reaction cup 900, magnetic bead is located on the front and rear wall of reaction cup 900 so that be inserted into suction in reaction cup 900
The magnetic bead in reaction cup 900 will not be siphoned away during liquid 4 imbibition of injection needle.Meanwhile, cause inhaling by the change of each pole pair N-S poles
Magnetic bead in the gap reaction cup 900 of liquid is moved, and magnetic bead is fully contacted with cleaning fluid, is washed off nonadherent in magnetic
The reagent of bead surface.
Embodiment 2
The present embodiment provides a kind of analyzer reagent warehouse structure, as shown in Figure 1：
The different differences with embodiment 1 of the pole orientation of a last magnetic pole group, (such as pole pair pole orientation is followed successively by
S-N, S-N, S-N, S-N；N-S, N-S, N-S, N-S；N-S, N-S, S-N, S-N；N-S, N-S, S-N, S-N；N-S, N-S, S-N,
S-N；N-S, N-S, S-N, S-N), the pole pair of last magnetic pole group sets height gradually to reduce, and latter magnetic pole group is with before
One magnetic pole group declines 5-8mm compared to height.
Using the above-mentioned desirable embodiment according to the present invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to its technical scope is determined according to right.
Claims (6)
1. a kind of analyzer disc type cleaning device, it is characterised in that including cleaning disc mechanism, imbibition mechanism for filling liquid and uniform shaking mechanism
(3)；
The cleaning disc mechanism includes：
Cylinder (1), with circular reaction cup run channel (11)；
Disk (2), is rotatably arranged in cylinder (1), isometrical on disk (2) to be placed with a circle reaction cup receiving hole, reaction
Cup (900) can be inserted in reaction cup receiving hole；
Some magnetic pole groups, are arranged in cylinder (1) and are sequentially arranged along reaction cup (900) traffic direction, each magnetic pole group has position
Pole pair in some reaction cup run channel (11) both sides is constituted, and each magnetic pole group at least has two and is located at reaction cup run channel
(11) pole pair of both sides, the pole orientation phase of the magnet in addition to last magnetic pole group in each magnetic pole group in each pole pair
Together, the pole orientation of two neighboring pole pair is on the contrary, the pole orientation of the magnet in each pole pair of last magnetic pole group
Identical or different and pole pair sets height gradually to reduce；
The imbibition injection needle (4) of imbibition mechanism for filling liquid can be extend into when needing imbibition and fluid injection each magnetic pole group last
In reaction cup (900) on the corresponding position of pole pair；
The uniform shaking mechanism (3) is located between two magnetic pole groups.
2. analyzer disc type cleaning device according to claim 1, it is characterised in that latter in last magnetic pole group
Pole pair height compared with previous pole pair declines 5-8mm.
3. analyzer disc type cleaning device according to claim 1, it is characterised in that uniform shaking mechanism (3) includes：Lifting is driven
Moving part, lifter plate, be fixed on cylinder (110) bottom shakes up actuator (310), by shaft coupling with shaking up actuator (310)
The rocking bar (311) of connection, is arranged on the eccentric cup (330) at the top of rocking bar (311), is fixed on cylinder (110) and extend into circle
The lid wheel for covering at the top of reaction cup (900) is provided with flexure strip (321) at the top of disk (120), flexure strip (321)
(322), lid wheel (322) bottom has the circle wheel that can extend into reaction cup (900), the axis of eccentric cup (330) and rocking bar
(311) axis is not conllinear, when being shaken up to reaction cup (900), and lifting actuator driving lifter plate rises, and shakes up driving
Part (310), rocking bar (311), eccentric cup (330) rise with lifter plate, and eccentric cup (330) is by reaction cup (900) jack-up, reaction cup
(900) the lid wheel (322) of flexure strip (321) is propped up at the top of, reaction cup (900) is fixed again, and actuator (310) is shaken up afterwards
Start, rock reaction cup (900) by eccentric cup (330), shake up reaction cup (900) interior liquid, lid wheel (322) bottom tool
There is silastic-layer, when shaking up, shaking up actuator (310) makes reaction cup (900) to a direction with 600-1200 rpms
Speed rotates 8-15s.
4. analyzer disc type cleaning device according to claim 3, it is characterised in that the axis of eccentric cup (330) with
The distance of the axis of rocking bar (311) is 1/8 to the 1/4 of reaction cup (900) width.
5. the analyzer disc type cleaning device according to claim 3 or 4, it is characterised in that analyzer disc type cleaning device,
Characterized in that, the eccentric cup (330) of the uniform shaking mechanism (3) before last magnetic pole group has magnetic, magnetic pole is located at top bottom two
End.
6. the analyzer disc type cleaning device according to claim any one of 1-5, it is characterised in that imbibition mechanism for filling liquid
Imbibition injection needle (4) can be extend into when needing imbibition and fluid injection on the corresponding position of each last pole pair of magnetic pole group
Reaction cup (900) in, after imbibition and fluid injection terminate, then imbibition injection needle (4) taken out, except last root imbibition injection needle
(4) outside, remaining imbibition injection needle (4) is respectively provided with the pipette be arrangeding in parallel and liquid injection pipe, last root imbibition injection needle (4)
Only there is pipette.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498780.0A CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498780.0A CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107252793A true CN107252793A (en) | 2017-10-17 |
| CN107252793B CN107252793B (en) | 2023-04-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710498780.0A Active CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
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| Country | Link |
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| CN (1) | CN107252793B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108169309A (en) * | 2017-12-14 | 2018-06-15 | 安徽九陆生物科技有限公司 | A kind of rotating disc type measuring cup carrier mechanism and its application method |
| CN109655627A (en) * | 2018-12-17 | 2019-04-19 | 宁波海壹生物科技有限公司 | A kind of cleaning device with incubation function |
| CN110082549A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | Cleaning device and chemiluminescence detector |
| CN110404910A (en) * | 2019-07-26 | 2019-11-05 | 深圳迎凯生物科技有限公司 | Cleaning method, cleaning device and immunity analysis instrument |
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| CN207154285U (en) * | 2017-06-27 | 2018-03-30 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer disc type cleaning device |
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| CN203426088U (en) * | 2013-08-22 | 2014-02-12 | 钟伟明 | Magnetic bead washing device |
| CN103599898A (en) * | 2013-10-29 | 2014-02-26 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer magnetic bead washing device |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108169309A (en) * | 2017-12-14 | 2018-06-15 | 安徽九陆生物科技有限公司 | A kind of rotating disc type measuring cup carrier mechanism and its application method |
| CN108169309B (en) * | 2017-12-14 | 2019-11-22 | 安徽九陆生物科技有限公司 | A kind of rotating disc type measuring cup carrier mechanism and its application method |
| CN110082549A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | Cleaning device and chemiluminescence detector |
| CN110082549B (en) * | 2018-01-25 | 2023-10-10 | 深圳市新产业生物医学工程股份有限公司 | Cleaning device and chemiluminescence detector |
| CN109655627A (en) * | 2018-12-17 | 2019-04-19 | 宁波海壹生物科技有限公司 | A kind of cleaning device with incubation function |
| CN110404910A (en) * | 2019-07-26 | 2019-11-05 | 深圳迎凯生物科技有限公司 | Cleaning method, cleaning device and immunity analysis instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107252793B (en) | 2023-04-07 |
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