CN104345158A - Automatic analysis apparatus and automatic analysis method - Google Patents

Automatic analysis apparatus and automatic analysis method Download PDF

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Publication number
CN104345158A
CN104345158A CN201310324968.5A CN201310324968A CN104345158A CN 104345158 A CN104345158 A CN 104345158A CN 201310324968 A CN201310324968 A CN 201310324968A CN 104345158 A CN104345158 A CN 104345158A
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Prior art keywords
unit
reaction
sample
reaction vessel
cleaning
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CN201310324968.5A
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约翰·李
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SUZHOU HAOOUBO BIOPHARMACEUTICAL CO Ltd
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SUZHOU HAOOUBO BIOPHARMACEUTICAL CO Ltd
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Priority to CN201310324968.5A priority Critical patent/CN104345158A/en
Publication of CN104345158A publication Critical patent/CN104345158A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0446—Combinations of the above

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention relates to an automatic analysis apparatus. The apparatus includes a reaction container supply unit, a reagent warehouse receipt, a sample transfer unit, a reaction incubation unit, a cleaning and separating unit, a detection unit, a sample adding unit, a transfer unit and a control system. An automatic analysis method using the automatic analysis apparatus includes the following steps: (1) supplying a reaction container; (2) adding an analysis sample and an analysis reagent; (3) reacting; (4) cleaning, and separating; (5) adding a detection reagent; (6) reacting; and (7) detecting. The automatic analysis apparatus and the automatic analysis method can flexibly realize a variety of test modes and reaction times, reduce the size of a whole machine, reduce the cost, and make the whole machine have a compact structure; and the automatic analysis apparatus has scalability, can easily realize high speed test, and is suitable for analysis under different test modes and reaction times.

Description

Automatic analysing apparatus and automatic analysis method
Technical field
The present invention relates to a kind of analytical instrument and analytical approach, especially relate to a kind of instrument carrying out immunoassay of robotization and utilize this instrument to carry out the method for immunoassay.
Background technology
Immunoassay is the analytical approach utilizing antigen and antibody specific association reaction to detect the micro substances such as protein, hormone, medicine.Immunoassay can be divided into non-marked immuno analytical method and labelling immunoassay technology.Labelling immunoassay technology successively experienced by radioimmunology analysis, enzyme exempts to analyze, the development of fluoroimmunoassay and time-resolved fluoroimmunoassay and chemiluminescence immune assay.Chemiluminescence immune assay (Chemiluminescence Immunoassay, CLIA), it is the detection analytical technology that will there is highly sensitive chemical luminescent detecting technology combine with the immune response of high specific, have highly sensitive, high specificity, sensing range are wide, easy-to-operate and automaticity advantages of higher, develop at present and apply the fastest immune analysis method, substitute traditional Measurement for Biotechnique just gradually, become the Main Means of clinical immunization diagnosis.
Chemical illumination immunity analysis instrument utilizes chemiluminescence immune assay principle by the detecting instrument of the step robotizations such as the application of sample in manual operation, reaction, cleaning separation, detection.
In existing immunity analysis instrument technology, conventional implementation is: provide one to react incubation rotating disk or track, adds the sequence of operations such as reaction vessel, application of sample, reaction incubation, cleaning separation and detection and all realizes around rotating disk or track.Because cleaning is separated, (B/F is separated, Bound-free) time, magnetic field needs the absorption continued the magnetic particle in reaction vessel and compound thereof, and the requirement of pick-up unit continuous detecting differential responses container inner analysis thing signal, rotating disk or track each cycle must and 1 position of can only advancing.The dirigibility of this fixing movement limit test, each test can only perform by exact sequence, operations such as adding reaction vessel, application of sample, reaction incubation, cleaning separation and detection is completed according to identical testing process, as instrument can only carry out single stage method or two-step approach test pattern, (single stage method refers to cleaning separation 1 time, two-step approach refers to cleaning separation 2 times), the reaction time of each test also must be changeless.The reaction process pattern that this unification is fixing and reaction incubative time (being called for short the reaction time) cannot accomplish to all test events it is all optimum, thus reduce the performances such as the sensitivity of some test event and measurement range.On the other hand, this implementation, in order to support two-step approach analytical model, at least needs two cover washing separator structures and two cover reagent needles, simultaneously in order to avoid the interference of different parts, require that the size of rotating disk or track is very large, thus cause that instrument volume is large, cost is high, lucifuge difficulty is high.Due to the restriction of volume, cost, this scheme is also generally difficult to realize high speed test.
Another kind of implementation realizes for reaction incubation and cleaning are separated on a rotating disk or track, detect and realize on another rotating disk (being called for short detection dish), this scheme will detect independent, detection can be made not by the impact of other operation, structure is easier to realize lucifuge, but there is test pattern equally and the reaction time is single, instrument volume is large, high in cost of production problem.
Summary of the invention
The object of this invention is to provide a kind of can flexibly and carry out immunoassay accurately and the automatic analysing apparatus that small volume, cost are lower, limitation is less and adopt this device to carry out the automatic analysis method of immunoassay.
For achieving the above object, the technical solution used in the present invention is:
A kind of automatic analysing apparatus, it comprises
Reaction vessel feed unit, is placed with some reaction vessels in described reaction vessel feed unit;
Agent bin unit, have several in described agent bin unit and place the reagent position filling the reagent container of analytical reagent, and described agent bin unit has absorption reagent sites, the reagent position described in each all can move to described absorption reagent sites;
Sample delivery unit, described sample delivery unit is provided with several and places the sample position filling the sample container of analyzing samples, and described sample delivery unit has absorption sample position;
Reaction incubation unit, described reaction incubation unit comprises the reaction vessel position that several carry out reacting incubation, and described reaction incubation unit has transfer port and stock layout position, the reaction vessel position described in each all can move to described transfer port or described stock layout position;
Cleaning separative element, is provided with several cleanings and point offs normal, and described cleaning separative element has cleaning transferring position in described cleaning separative element, and the cleaning described in each divides to off normal and all can move to described cleaning transferring position;
Detecting unit, the pick-up unit that described detecting unit comprises several detection reaction incubation positions of carrying out detection reaction, detects the reaction product after detection reaction, described detecting unit has detection position and detects transferring position, described pick-up unit is corresponding with described detection position, and the reaction vessel on the detection reaction incubation position described in each all can shift or move to described detection transferring position or/and described detection position;
Application of sample unit, described application of sample unit can move and can draw and discharge described analyzing samples and/or described analytical reagent in described automatic analysing apparatus, and described absorption reagent sites, described absorption sample position, described stock layout position are all positioned on the motion track of described application of sample unit;
Buanch unit, described buanch unit can move and can shift described reaction vessel in described automatic analysing apparatus, and described reaction vessel shifts by described buanch unit between described reaction vessel feed unit, described reaction member, described cleaning separative element, described detecting unit;
Control system, described control system is connected with described reaction vessel feed unit, described agent bin unit, described sample delivery unit, described reaction incubation unit, described cleaning separative element, described detecting unit, described application of sample unit, described buanch unit respectively and controls the movement of above-mentioned each unit or state.
Described automatic analysing apparatus also comprises blending unit, on the motion track that described blending unit is arranged in described buanch unit or be integrated in described reaction incubation unit.
Described automatic analysing apparatus also comprises reaction vessel recovery area, and described reaction vessel recovery area has reaction vessel and abandons position, and described reaction vessel abandons position and is positioned on the motion track of described buanch unit.
Described agent bin unit is the rotary-disk type structure comprising agent bin rotating disk, described reagent position be multi-turn annular distribution on described agent bin rotating disk, described reagent position has and to be connected with described control system and to drive the free-wheeling system of its rotation.
Be provided with several adapters in described agent bin unit, described reagent position is positioned on described adapter and the reagent position each described adapter had described in several.
Described agent bin unit also comprises the refrigerating plant making it be in frozen state.
Described sample delivery unit is comprise the rotary-disk type structure of sample rotating disk or comprise the rail mounted structure of path, and described sample position is that multi-turn annular distribution is on described sample rotating disk; Be provided with several sample racks in described sample delivery unit, described sample position is positioned on described sample rack and the sample position each described sample rack had described in several.
Described reaction incubation unit is comprise the rail mounted structure of reaction rail or comprise the rotary-disk type structure of reaction rotating disk, and described reaction vessel position is positioned on described reaction rail or described reaction rotating disk.
Described reaction vessel position is that multi-turn annular distribution is on described reaction rotating disk.
Also be provided with in described reaction incubation unit and be connected with described control system and make the reaction thermostatic control system of temperature stabilization in described reaction incubation unit.
Described cleaning separative element is comprise the rail mounted structure of cleaning track or comprise the rotary-disk type structure of cleaning rotating disk, and described cleaning separative element also comprises the magnetic collecting mechanism, mixing mechanism, mechanism for filling liquid and the liquid sucting mechanism that produce magnetic field.
Be provided with in described cleaning separative element and be connected with described control system system and make the cleaning thermostatic control system of temperature stabilization in described cleaning separative element.
The detection reaction incubation position of described detecting unit is integrated in described cleaning separative element or is arranged at independently to be detected on incubation rotating disk.
On described cleaning rotating disk the cleaning comprised described at least one circle divide off normal, detection reaction incubation position described at least one circle.
Described buanch unit comprises the shift module that several have different motion track.
Described application of sample unit comprises the application of sample module that several have different motion track.
Described control system comprises man-machine interaction unit, the control module be connected with described man-machine interaction unit, the temperature regulation section that is connected with described control module are divided and motion control portion and other control sections, the storage unit be connected with described control module with described man-machine interaction unit respectively and data processing unit; Described reaction vessel feed unit, described agent bin unit, described sample delivery unit, described reaction incubation unit, described cleaning separative element, described application of sample unit, described buanch unit are connected with described motion control portion respectively, described agent bin unit, described reaction incubation unit, described cleaning separative element, described detecting unit divide with described temperature regulation section respectively and are connected, and described detecting unit is connected with described data processing unit.
The automatic analysis method utilizing above-mentioned automatic analysing apparatus to carry out, comprising:
(1) supply: by described reaction vessel feed unit supply response container, by described buanch unit, described reaction vessel is transferred to the transfer port of described reaction incubation unit, more described reaction vessel is moved to the stock layout position of described reaction incubation unit by described reaction incubation unit;
(2) application of sample: described application of sample unit draws described analyzing samples in the absorption sample position of described sample delivery unit, described analyzing samples is expelled in described reaction vessel by the stock layout position moving to described reaction incubation unit; After described application of sample unit draws described analytical reagent on the absorption reagent sites of described agent bin unit, described analytical reagent is expelled in described reaction vessel by the stock layout position moving to described reaction incubation unit;
(3) react: the described analyzing samples in described reaction vessel and described analytical reagent are reacted in described reaction incubation unit;
(4) clean: the cleaning transferring position by the transfer port of described reaction incubation unit, described reaction vessel being transferred to described cleaning separative element by described buanch unit, and move described reaction vessel to described cleaning by described cleaning separative element and divide to off normal cleaning separation is carried out to described potpourri wherein;
(5) add detection reagent: described detection reaction incubation position to through described cleaning be separated after described in reaction vessel in add detection reagent;
(6) detection reaction: carry out detection reaction in described detection reaction incubation position;
(7) detect: by described buanch unit, the reaction vessel described in after detection reaction is shifted out described detection reaction incubation position from described detection transferring position, shifted by described buanch unit or described detecting unit again or move to the detection position of described detecting unit, by described pick-up unit, the potpourri in described reaction vessel being detected.
After the analyzing samples described in discharging and described analytical reagent to described reaction vessel, also comprise and the potpourri in described reaction vessel is mixed.
Because technique scheme is used, the present invention compared with prior art has following advantages:
1, automatic analysing apparatus of the present invention divides according to the function of operation, especially incubation unit, cleaning separative element and detecting unit independently layout will be reacted, achieve flexible motion, effectively support the reaction time of multiple test pattern and flexibility and changeability, and apparatus structure easily realizes lucifuge, and reduce machine volume, reduce cost, make compact integral structure; Meanwhile, this automatic analysing apparatus also possesses extendability, can be easy to realize high speed test.
2, automatic analysis method of the present invention can carry out multiple analytical reactions neatly, is applicable to the analysis under different test patterns and reaction time.
Accompanying drawing explanation
Accompanying drawing 1 is the structure schematic top plan view of the first embodiment of the automatic analysing apparatus of embodiments of the invention one.
Accompanying drawing 2 is the schematic diagram of the control system of the automatic analysing apparatus of embodiments of the invention one.
The schematic flow sheet of accompanying drawing 3 for utilizing the automatic analysing apparatus of embodiments of the invention one to carry out a step automatic analysis method.
The schematic flow sheet of accompanying drawing 4 for utilizing the automatic analysing apparatus of embodiments of the invention one to carry out two step automatic analysis methods.
The schematic flow sheet of accompanying drawing 5 for utilizing the automatic analysing apparatus of embodiments of the invention one to carry out a time delay one step automatic analysis method.
The schematic flow sheet of accompanying drawing 6 for utilizing the automatic analysing apparatus of embodiments of the invention one to carry out twice time delay one step automatic analysis method.
Accompanying drawing 7 is the structure schematic top plan view of the automatic analysing apparatus of embodiments of the invention two.
Accompanying drawing 8 is the structure schematic top plan view of the automatic analysing apparatus of embodiments of the invention three.
Accompanying drawing 9 is the structure schematic top plan view of the automatic analysing apparatus of embodiments of the invention four.
Figure 10 is the schematic top plan view of the second embodiment of the automatic analysing apparatus of embodiments of the invention one.
Figure 11 is the schematic top plan view of the third embodiment of the automatic analysing apparatus of embodiments of the invention one.
Embodiment
Below in conjunction with embodiment shown in the drawings, the invention will be further described.
Embodiment one: shown in accompanying drawing 1.
A kind of automatic analysing apparatus 1, it comprises reaction vessel feed unit 9, agent bin unit 8, sample delivery unit 7, reaction incubation unit 2, cleaning separative element 3, detecting unit 4, application of sample unit 6, buanch unit 5, control system 100 and blending unit 11, cleaning device, reaction vessel recovery area 16, detects the parts such as load reagents district 17, devil liquor recovery district 18, liquid supply area 19.
Introduce each several part in detail below.
Reaction vessel feed unit 9 is used to hold and provides the reaction vessel needed for analytical test, be wherein placed with some reaction vessels, and reaction vessel feed unit 9 has supply for receptacles position.As once held 1000 reaction vessels in reaction vessel feed unit 9, in order to reduce the pollution between test, reaction vessel is single use, and reaction vessel can be reaction cup or reaction tube etc.In the present embodiment, reaction vessel is reaction tube.It will be understood by those skilled in the art that reaction vessel feed unit 9 can hold the flat board of proper alignment, pallet or carrier structure, dull and stereotyped, pallet or bracket having the position, reaction vessel hole of proper alignment, for holding reaction vessel.Reaction vessel feed unit 9 also can be bin type structure, can hold the reaction vessel of stacking at random.In the present embodiment, reaction vessel feed unit 9 is bin type structure, and reaction vessel is stacking at random wherein, more convenient like this operating personnel's operation.Operating personnel are when adding reaction vessel, only need become the bag (reaction vessel of every packed some, as 500) reaction vessel is poured in reaction vessel feed unit 9, reaction vessel feed unit 9 can by reaction vessel auto arrangement, and sequence transfer on supply for receptacles position.The motion of reaction vessel feed unit 9 can be realized by general control and kinematic train and topworks.
Agent bin unit 8 is the containers for holding analytical reagent.There are in agent bin unit 8 several and place the reagent position filling the reagent container of analytical reagent, and agent bin unit 8 both can adopt three-dimensional space arrangement or hierarchy, also can adopt rotary-disk type structure.In the present embodiment, agent bin unit 8 adopts rotary-disk type structure, it comprises an agent bin rotating disk rotated around axis, and reagent position is, and multi-turn annular distribution is on agent bin rotating disk, such as be divided into outer, in, Nei Sanquan, can space be made full use of like this, to hold more reagent container, make compact integral structure.Agent bin unit 8 has absorption reagent sites, and each reagent position all can move to absorption reagent sites, and namely agent bin unit 8 stops by turning, and advances at every turn or retreats certain distance, and a certain reagent container is moved to absorption reagent sites wait absorption reagent.Because immunoassay generally can use magnetic particle reagent component, before this reagent component of each absorption, magnetic particle reagent component is needed to keep uniform suspended state, to ensure test result accurately and reliably, therefore one preferably, wherein one enclose the reagent position 8a of such as inner ring for holding magnetic particle reagent container, and these reagent positions have and to be connected with control system 100 and to drive the free-wheeling system of its rotation, free-wheeling system can comprise the engaging mechanisms such as gear, reagent position can be realized except rotating except location around the central shaft of agent bin rotating disk, can also around self axle rotation, to mix the function of the magnetic particle reagent in reagent container.Except placing common reagent container, agent bin unit 8 can also arrange several adapters 8a, and each adapter 8a can arrange multiple reagent position, is applicable to the multiple projects only having 1 composition component different, the space of agent bin unit 8 can be saved like this, also handled easily.Agent bin unit 8 is generally also provided with and makes it be in frozen state refrigerating plant, for the refrigeration of reagent, can improve the stability of reagent.
Sample delivery unit 7 for transmitting sample container, as sample tube, micro-cup etc.Sample delivery unit 7 can be rotating disk transfer structure or track transfer structure etc., sample delivery unit 7 is provided with several and places the sample position filling the sample container of analyzing samples.In the present embodiment, sample delivery unit 7 adopts rotary-disk type structure, it comprises the sample rotating disk rotated around axis in rotary-disk type structure, and sample position is that multi-turn ring-type is arranged on sample rotating disk, sample rotating disk such as, is provided with inside and outside two circles, amounts to 60 sample positions.Conveniently user operation and use, sample delivery unit 7 one kinds of preferred implementations are the structure of adaptive sample rack, several sample racks are provided with in sample delivery unit 7, each sample rack is arranged the sample position of certain position, such as sample delivery unit 7 can be designed to accommodation 6 sample racks, and each sample rack arranges 10 sample positions.Sample delivery unit 7 has absorption sample position, and each sample position all can move to absorption sample position.During test, sample delivery unit 7 stops by turning, and advances at every turn or retreats certain distance, the sample of Water demand is moved to absorption sample position, to wait to draw corresponding sample.The motion of sample delivery unit 7 is realized by general control and kinematic train and topworks, comprises drived control, motor, Timing Belt or the assembly such as gear, position transducer, is not described in detail.
Reaction incubation unit 2 comprises several reaction vessel positions of carrying out reacting, and reaction vessel position is that position, hole or cartridge structure are for holding reaction vessel.Reaction incubation unit 2 can be the rail mounted structure comprising reaction rail, also can be the rotary-disk type structure comprising reaction rotating disk, and reaction vessel position is located on reaction rail or reaction rotating disk.In the present embodiment, adopt rotary-disk type structure, and reaction vessel position is, and multi-turn annular distribution is on reaction rotating disk, concrete, sample turret loop is arranged around reaction rotating disk, reaction vessel position on reaction rotating disk is divided into inside and outside two circles, with the more reaction vessels of less space, to make compact integral structure.Also be provided with the reaction thermostatic control system 100 making temperature stabilization in reaction incubation unit 2 in reaction incubation unit 2, this reaction thermostatic control system 100 comprises well heater, temperature sensor and corresponding control circuit etc.As regulated the temperature in reaction incubation unit 2 at 37 DEG C, the reaction sample in reaction vessel and reaction reagent is made to carry out reaction incubation in this reaction incubation unit 2.In addition, move into after on reaction incubation unit 2 at reaction vessel, reaction vessel can also react preheating certain hour in incubation unit 2 before application of sample, as 2min, reinject reaction sample and reaction reagent, can ensure that the initial temperature condition of each reaction is consistent like this, be conducive to the consistance of measurement result.Reaction incubation unit 2, except holding reaction vessel preheating and incubation reaction, also has the function of transhipment reaction vessel, and namely react incubation unit 2 and have transfer port and stock layout position, each reaction vessel position all can move to transfer port or stock layout position.
Be provided with several cleanings point in cleaning separative element 3 to off normal, and cleaning separative element 3 has cleaning transferring position, each cleaning point is offed normal and all can be moved to cleaning transferring position.Cleaning separative element 3 is comprise the rail mounted structure of cleaning track or comprise the rotary-disk type structure of cleaning rotating disk, in the present embodiment, adopt rotary-disk type structure, cleaning on it divides to off normal and distributes in the form of a ring, the distance that each test period advance is fixing, the cleaning mainly completing reactant in reaction vessel is separated, and is removed by the reactant not having to combine, leaves the magnetic particle compound of combination.Cleaning separative element 3 also comprises the magnetic collecting mechanism, mixing mechanism, mechanism for filling liquid and the liquid sucting mechanism that produce magnetic field.Magnetic collecting mechanism is for collecting magnetic particle, and it can be permanent magnet, permanent magnet array combination or electromagnetic field etc., in the present embodiment, and preferred permanent magnet array combination.Permanent magnet array combination produces magnetic field, the magnetic particle in reaction vessel is adsorbed on inwall, is beneficial to liquid sucting mechanism and is siphoned away by unconjugated reactant.Mechanism for filling liquid injects cleaning fluid again in the reaction vessel after siphoning away non-combine reactants through liquid sucting mechanism, the magnetic particle that mixing mechanism makes absorption even suspension again again, and then absorption, imbibition, note cleaning fluid, resuspension, so repeatedly several times, thoroughly to clean residual non-bond.The motion of cleaning separative element 3 is realized by general control and kinematic train and topworks.In order to reduce the impact of variation of ambient temperature, cleaning separative element 3 generally has thermostatic control system, can ensure the consistance of measurement result.Thermostatic control system is completed by the devices such as well heater, stability sensor and corresponding control circuit and assembly.
Reaction incubation unit 2 and the separate layout of cleaning separative element 3, in one-period, repeatedly can turn and stop, each rotation can be advanced optional position, achieve flexible motion, reaction incubation unit 2 can facilitate realization to add reaction vessel, add reaction sample, add reaction reagent and reaction and the operation such as to hatch, effectively support the incubative time of multiple test pattern and flexibility and changeability.The separated layout that it is pointed out that herein refer to reaction incubation unit 2 and cleaning separative element 3 structurally independent, and to be controlled by independently control section respectively.Be set up as at space cloth, both can be mutually nested, and such as, in order to further conserve space, reaction incubation unit 2 is arranged in the outside of cleaning separative element 3, namely cleans separative element 3 and be nested on reaction incubation unit 2.
Detecting unit 4 comprises the detection reaction incubation position that several carry out detection reaction, to the pick-up unit that the reaction product after detection reaction detects, detecting unit also has detection position 4a and detects transferring position 4b, pick-up unit is corresponding with detection position, reaction vessel on each detection reaction incubation position all can move or be transferred to detection transferring position or detecting position is set up, here, detect transferring position refer to be positioned at buanch unit 5 motion track on a fixed position corresponding with detection reaction incubation position, for by reaction vessel from cleaning separative element shift into detecting unit or after detection reaction is completed reaction vessel to be detected migrate out detection reaction incubation position.In the present embodiment, detecting transferring position and the coincidence of cleaning transferring position, is same position.Pick-up unit detects the luminous signal being positioned at the reaction vessel that detecting position is put on 4a, and it comprises tripper, detection means (as photomultiplier PMT), detects the structure such as light path and testing circuit.Detecting unit 4 is independent of reaction incubation unit 2 and cleaning separative element 3 layout, and pick-up unit detects the reaction vessel detected on the 4a of position, can not be subject to the impact of reaction incubation unit 2 and cleaning separative element 3, structure easily realizes lucifuge.Detecting unit 4 also possesses extensibility, can modular design, can the type of different flux and seriation type general, not only can make compact integral structure, exploitation and complete machine cost can also be saved.
It will be understood by those skilled in the art that the detection reaction after cleaning separation both can be carried out on cleaning separative element, also can carry out in one independently unit.Therefore, detection reaction incubation position can be integrated in cleaning separative element, also can be arranged at one and independently detect on incubation rotating disk 30.Therefore the present embodiment can have following three kinds of embodiments:
The first embodiment is as shown in Figure 1: the injection of the detection reagent after cleaning is separated can complete on cleaning separative element 3, namely in the present embodiment, the detection reaction incubation position of detecting unit 4 is integrated in cleaning separative element 3, and detection reaction incubation position correspondence is provided with and detects reagent injecting mechanism.After detection reagent injecting mechanism injects and detects reagent in reaction vessel, the detection reaction incubation position on cleaning separative element 3 completes detection reaction, and reaction is generally a few minutes, as 3 minutes.The resource on cleaning separative element 3 can be made full use of like this, cost-saving.
The second embodiment is as shown in Figure 10: the detection reaction incubation position of detecting unit 4 is positioned at independently on detection reaction rotating disk 30.The injection of the detection reagent after cleaning is separated can complete on cleaning separative element 3, after detection reagent injecting mechanism injects and detects reagent in reaction vessel, by buanch unit 5, reaction vessel is shifted out from cleaning separative element 3, shift into detection incubation rotating disk 30 from detection transferring position 4b, detection reaction incubation position on detection reaction rotating disk 30 completes detection reaction, reaction is generally a few minutes, as 3 minutes.The injection of certain detection reagent also can complete on detection reaction rotating disk 30.After detection reaction completes, reaction vessel by buanch unit 5 after testing transferring position 4b transfer to detect position 4a carry out input by pick-up unit 4.Detection reaction completes independently detecting on incubation rotating disk 30, detection reaction can be made independent of cleaning separative element 3 and detecting unit 4, do not separate the restriction of unit 3 and detecting unit 4 by cleaning, thus make detection reaction more flexible, realize the detection reaction time flexibly.
The third embodiment is as shown in figure 11: the detection reaction incubation position of detecting unit 4 is positioned at independently to be detected on incubation rotating disk 30.The injection of the detection reagent after cleaning is separated can complete on cleaning separative element 3.After detection reagent injecting mechanism injects and detects reagent in reaction vessel, by buanch unit 5, reaction vessel is shifted out from cleaning separative element 3, shift into detection incubation rotating disk 30 from detection transferring position 4b, detection reaction incubation position on detection incubation rotating disk 30 completes detection reaction, reaction is generally a few minutes, as 3 minutes.The injection of certain detection reagent also can complete on detection incubation rotating disk 30.Detect its path when incubation rotating disk 30 rotates, through detecting position, after therefore detection reaction completes, directly reaction vessel to be moved to by detection incubation rotating disk 30 and detect position and carry out input by pick-up unit.This embodiment achieves detection reaction flexibly while the transfer number reducing buanch unit 5.
Application of sample unit 6 can move and can draw and discharge analyzing samples and/or analytical reagent in automatic analysing apparatus 1, and its motion track is straight line or curve.Absorption reagent sites, absorption sample position, stock layout position are all positioned on the motion track of application of sample unit 6, and the cleaning device with cleaning position 14 and reinforcement cleaning position 15 is also positioned on the motion track of application of sample unit 6.In the present embodiment, the Internal and external cycle sample position center circle of running orbit and the sample delivery unit 7 of application of sample unit 6, agent bin unit 8 three enclose reagent position center circle, react outer inner ring pipe position center circle, the cleaning position 14 on incubation unit 2 and strengthen cleaning position 15 crossing respectively.Application of sample unit 6 can horizontally rotate and upper and lower vertical movement, complete the absorption of analyzing samples and each reagent component, discharge, its by motion, adopt the parts such as parts, syringe pump, solenoid valve to form, moving is realized by general control and kinematic train and topworks.In concrete enforcement, employing parts can be the form of needle tubing and disposable suction nozzle (Tip), thoroughly can eliminate the Residual contamination of sample like this, in the present embodiment, employing parts are probe, clean after completing application of sample in cleaning position 14 at every turn, to reduce or to prevent Residual contamination, in order to make probe clean up further, the reinforcement cleaning fluid strengthened on cleaning position 15 can also be utilized to carry out reinforcement cleaning to pin.
Buanch unit 5 can move and can transfer reaction container in automatic analysing apparatus 1, its motion track is straight line or curve, the mode of transfer reaction container can be push rod, guide rail, pallet and gripping structure etc., in this enforcement, buanch unit 5 there is gripping structure, can pick-and-place reaction vessel, and horizontally rotate and vertical up-or-down movement.The running orbit of buanch unit 5 respectively with reaction vessel supply position 9a, detect position 4a or/and the outer inner ring reaction vessel die circle detected on reaction vessel die circle, blending unit 11 and the reaction member 2 on transferring position 4b, cleaning unit 3 is crossing, buanch unit 5 is at these position of intersecting point transfer reaction containers, it is to be noted, when automatic analysing apparatus does not have blending unit 11 or blending unit 11 is integrated on other unit, buanch unit 5 level run track is without blending unit 11.The intersection point of the pipe position center circle on the running orbit of buanch unit 5 and cleaning unit 3 is defined as cleaning transfer port, is defined as reacts outer ring and inner ring transfer port (not marking in figure) with the intersection point of the outer inner ring pipe position center circle on reaction member 2.The motion of buanch unit 5 is realized by general control and kinematic train and topworks.
On the motion track that blending unit 11 is arranged in buanch unit 5 or be integrated in reaction incubation unit 2, it can mix the reaction mixture in reaction vessel, and blending manner can be the modes such as ultrasound wave, vibration, rotation.Make the reaction homomixture uniform state in reaction vessel, can reaction process be accelerated.It will be appreciated by those skilled in the art that, blending unit 11 or blending unit 11 is not needed to be integrated on other unit in some implementation, when such as blending unit 11 is integrated on reaction incubation unit 2, reaction vessel on certain reaction vessel position on reaction incubation unit 2 is mixed, blending unit 11 goes back accessible site on application of sample unit 6, and sonic oscillation when utilizing application of sample unit 6 to inhale sample or stock layout completes the mixing to potpourri in reaction vessel.In the present embodiment, preferred blending unit 11, independent of other unit, when such blending unit 11 mixes, not by the constraint of other unit, can mix the reaction vessel of needs mixing flexibly.It is pointed out that when analytical equipment does not have blending unit 11 or blending unit 11 is integrated on other unit, buanch unit 5 level run track is without blending unit 11.
As shown in Figure 2, control system 100 respectively with reaction vessel feed unit 9, agent bin unit 8, sample delivery unit 7, react incubation unit 2, clean separative element 3, detecting unit 4, application of sample unit 6, buanch unit 5 be connected and control the movement of above-mentioned each unit or state.Concrete, control system 100 comprises man-machine interaction unit 110, the control module 101 be connected with man-machine interaction unit 110, the temperature regulation section that is connected with control module 101 divide 105 with motion control portion 104 and other control sections 106, the storage unit 103 be connected with control module 101 with man-machine interaction unit 110 respectively and data processing unit 102; Reaction vessel feed unit 9, agent bin unit 8, sample delivery unit 7, reaction incubation unit 2, cleaning separative element 3, detecting unit 4, application of sample unit 6, buanch unit 5 are connected with motion control portion 104 respectively, agent bin unit 8, reaction incubation unit 2, cleaning separative element 3, detecting unit 4 divide 105 to be connected with temperature regulation section respectively, and detecting unit 4 is connected with data processing unit 102.By this control system 100, the control of each several part motion and the control to temperature in this automatic analysing apparatus 1 can be realized neatly.Specifically, motion control portion 104 controls the motion of the unit such as reaction vessel feed unit 9, buanch unit 5, blending unit 11, reaction incubation unit 2, cleaning separative element 3, application of sample unit 6, sample delivery unit 7, agent bin unit 8, detecting unit 4; Temperature regulation section divides the refrigeration of 105 control agent bin unit 8, the constant temperature of reaction member, the temperature of the cleaning constant temperature of separative element 3, the constant temperature of detecting unit 4 etc. to regulate.Data processing unit 102 controls detecting unit 4 and detects and process data, data processing unit 102 and control module 101 interactive controlling signal and data.Operating personnel are mutual with the control system 100 of automatic analysing apparatus 1 by man-machine interaction unit 110, operating personnel are by the input operation as mouse-keyboard or the input equipment such as touch-screen, hand-held bar code scan instrument, to control system 100 sending controling instruction of automatic analysing apparatus 1, control system 100 passes through the output device such as display screen, printer to information such as operating personnel's display control information and data.Storage unit 103 carries out data and instruction stores.
Except each part mentioned above, reaction vessel recovery area 16, for reclaiming the reaction vessel after having detected, detects load reagents position 17 for placing the detection liquid detected, liquid supply area 19 for providing the liquid needed for analysis, as cleaning fluid etc.Wherein, reaction vessel recovery area 16 has reaction vessel and abandons position 13, and reaction vessel abandons position 13 and is positioned on the motion track of buanch unit 5.
Utilize above-mentioned automatic analysing apparatus 1 can be easy to realize the reaction time of multiple test pattern and flexibility and changeability.Put it briefly, automatic analysis method comprises the steps:
(1) supply: by reaction vessel feed unit 9 supply response container, by buanch unit 5, reaction vessel is transferred to the transfer port of reaction incubation unit 2, again reaction vessel is moved to the stock layout position of reaction incubation unit 2 by reaction incubation unit 2;
(2) application of sample: application of sample unit 6 draws analyzing samples in the absorption sample position of sample delivery unit 7, analyzing samples is expelled in reaction vessel by the stock layout position moving to reaction incubation unit 2; After application of sample unit 6 draws analytical reagent on the absorption reagent sites of agent bin unit 8, analytical reagent is expelled in reaction vessel by the stock layout position moving to reaction incubation unit 2; Potpourri in reaction vessel is mixed;
(3) react: the analyzing samples in reaction vessel and analytical reagent are reacted in reaction incubation unit 2;
(4) clean: the cleaning transferring position by the transfer port of reaction incubation unit 2, reaction vessel being transferred to cleaning separative element 3 by buanch unit 5, and offed normal by cleaning separative element 3 mobile response container to cleaning point cleaning separation is carried out to potpourri wherein;
(5) detection reagent is added: in the reaction vessel after cleaning is separated, add detection reagent in detection reaction incubation position;
(6) detection reaction: carry out detection reaction in detection reaction incubation position;
(7) detect: by buanch unit 5, the reaction vessel after detection reaction is shifted out detection reaction incubation position by detecting transferring position 4b, shifted or moved to the detection position 4a of detecting unit 4 again by buanch unit 5 or detecting unit 4, by pick-up unit, the potpourri in reaction vessel is detected.
Shown in 3, a step automatic analysis method (single stage method) is described in detail by reference to the accompanying drawings:
1, step 200 supplies reaction vessel, reaction vessel feed unit 9 supplies 1 new reaction container to reaction vessel supply position 9a, new reaction container is transferred to the reaction vessel position of reacting incubation unit 2 from reaction vessel supply position 9a by buanch unit 5 by the transfer port of reaction member, reaction incubation unit 2 rotates, and this reaction vessel is transported to stock layout position;
2, step 201 stock layout originally, sample delivery unit 7 inhales sample position absorption sample position by needing the sample drawn to be transported to, application of sample unit 6 draws sample from suction sample position, after drawing sample, application of sample unit 6 moves to the top of reaction incubation unit 2, at stock layout position stock layout originally in reaction vessel, after drained sample, application of sample unit 6 completes cleaning in cleaning position 14;
3, step 202 arranges reagent, agent bin unit 8 is transported to absorption reagent sites by needing the reagent component drawn, application of sample unit 6 draws reagent from absorption reagent sites, after drawing reagent, application of sample unit 6 moves to the top of reaction incubation unit 2, at stock layout position row's reagent in reaction vessel, after drained reagent, application of sample unit 6 completes cleaning in cleaning position 14;
4, step 203 mixes, the reaction vessel of drained sample and reagent is moved to transfer port by reaction incubation unit 2, reaction vessel is transferred to blending unit 11 from reaction incubation unit 2 by buanch unit 5, blending unit 11 mixes, after having mixed, reaction vessel is transferred back to the reaction vessel position on reaction incubation unit 2 by buanch unit 5 from blending unit 11;
5, step 204 is reacted, add sample, reagent reaction vessel after mixing reacts incubation on reaction incubation unit 2, the time of reaction incubation can change flexibly, as 3 minutes, 5 minutes, 11 minutes, 20 minutes can be reacted ... can set flexibly according to the performance of test event, after the reaction time of setting terminates, reaction incubation unit 2 rotates, and reaction vessel is transported to transfer port, and reaction vessel is transferred to cleaning separative element 3 from reaction incubation unit 2 by buanch unit 5;
6, step 205 B/F is separated, and reaction vessel goes forward one by one at cleaning separative element 3, adsorbs-draw non-bond-fluid injection and resuspension under magnetic field, repeatedly several times, thoroughly to clean residual non-bond;
7, step 206 is listed and indexed test agent, and B/F enters detection reagent after being separated in reaction vessel, detecting reagent and react with the potpourri in reaction vessel and produce light signal, in order to make reaction more fully, can mix when entering detection reagent;
8, step 207 detection reaction, enter after detecting reagent, usually need detection reaction a few minutes, certainly, what have does not need detection reaction, or detection reaction incubation is very short, enter that detect after reagent can direct-detection signal, in the present embodiment, after entering and detecting reagent, need detection reaction a few minutes, as 3 minutes.
It is to be noted, as the preferred mode of one, in the present embodiment, step 205 all completes to 207 on cleaning separative element 3, the resource on cleaning separative element 3 can be reused like this, compact conformation, cost-saving, certainly, step 206 and 207 also can complete beyond cleaning separative element 3, like this can be more flexible, makes step 206 and 207 not by the impact of cleaning separative element 3;
9, step 208 detects, after potpourri in reaction vessel completes detection reaction, reaction vessel is transferred to from cleaning separative element 3 and detects position 4a by buanch unit 5, pick-up unit detects the detection signal in reaction vessel, after converting detection signal to digital signal, be sent to data processing unit 102;
10, step 209 abandons reaction vessel, and buanch unit 5 is transferred to reaction vessel by completing the reaction vessel after detection abandons position 13 from detection position 4a, is reclaimed by reaction vessel recovery area 16.
Above-mentioned single stage method testing process completes under the control of the control system 100 shown in Fig. 2.
As shown in Figure 4, be that step 302 is to 306 with single stage method difference, all the other steps are identical with single stage method or similar, no longer illustrate for two-step approach flow process, stress that step 302 is to 308 below.
Step 302 ranked first reagent, first reagent can be a kind of reagent component or several reagent component, agent bin unit 8 is transported to absorption reagent sites by needing the reagent component drawn, application of sample unit 6 draws the first reagent from absorption reagent sites, after drawing the first reagent, application of sample unit 6 moves to above reaction incubation unit 2, and ranked first reagent in stock layout position, after drained first reagent, application of sample unit 6 completes cleaning in cleaning position 14;
Step 303 mixes, the reaction vessel of drained sample and the first reagent is transferred to transfer port by reaction member, reaction vessel is transferred to blending unit 11 from reaction incubation unit 2 by buanch unit 5, blending unit 11 mixes, after having mixed, reaction vessel is transferred back to the reaction vessel position on reaction incubation unit 2 by buanch unit 5 from blending unit 11;
Step 304 first is reacted, add sample, the first reagent reaction vessel after mixing carries out the first reaction incubation on reaction incubation unit 2, the time of the first reaction incubation can change flexibly, as 3 minutes, 5 minutes, 11 minutes, 20 minutes can be reacted ... can set flexibly according to the performance of test event, after the first reaction time of setting terminates, reaction member rotates, reaction vessel is transported to transfer port, and reaction vessel is transferred to cleaning unit from reaction incubation unit 2 by buanch unit 5;
Step 305 B/F is separated, reaction vessel goes forward one by one at cleaning unit, under magnetic field, adsorb-draw non-bond-fluid injection and resuspension, repeatedly several times, thoroughly to clean residual non-bond, after B/F has been separated, reaction vessel is transferred to reaction incubation unit 2 from cleaning unit by buanch unit 5, and reaction vessel is moved to stock layout position by reaction incubation unit 2.
Step 306 ranked second reagent, second reagent can be a kind of reagent component or several reagent component, agent bin unit 8 is transported to absorption reagent sites by needing the reagent component drawn, application of sample unit 6 draws the second reagent from absorption reagent sites, after drawing the second reagent, application of sample unit 6 moves to above reaction incubation unit 2, and ranked second reagent in stock layout position, after drained second reagent, application of sample unit 6 completes cleaning in cleaning position 14;
Step 307 mixes, the reaction vessel of drained sample and the second reagent is transferred to transfer port by reaction member, reaction vessel is transferred to blending unit 11 from reaction incubation unit 2 by buanch unit 5, blending unit 11 mixes, after having mixed, reaction vessel is transferred back to the reaction vessel position on reaction incubation unit 2 by buanch unit 5 from blending unit 11;
Step 308 second is reacted, add sample, the second reagent reaction vessel after mixing carries out the second reaction incubation on reaction incubation unit 2, the time of the second reaction incubation can change flexibly, as 3 minutes, 5 minutes, 11 minutes, 20 minutes can be reacted ... can set flexibly according to the performance of test event, after the second reaction time of setting terminates, reaction incubation unit 2 rotates, reaction vessel is transported to transfer port, and reaction vessel is transferred to cleaning separative element 3 from reaction incubation unit 2 by buanch unit 5.
Thereafter step is similar with single stage method or identical, and two step method testing process completes under the control of the control system 100 shown in Fig. 2.
On the basis of single stage method testing process, time delay single stage method can also be extended, time delay single stage method can be divided into again a time delay single stage method and twice time delay single stage method etc., a time delay single stage method is on the basis of single stage method flow process, increase reagent adding, mixing step and a primary first-order equation incubative time, and twice time delay single stage method is on the basis of single stage method flow process, increase by twice reagent adding, mixing step and twice reaction incubative time.The present invention can be easy to the reaction time realizing multiple test pattern and flexibility and changeability, also can support a time delay single stage method and twice time delay single stage method, and the testing process of a time delay single stage method and twice time delay single stage method and method are respectively as shown in Figure 5 and Figure 6.Compared with the single stage method flow process of Fig. 3, add respectively step 405 to 407, step 505 to 510, all reaction time can be arranged flexibly according to project characteristic, and these flow processs can meet the special requirement of some test event.
On the basis of two-step approach testing process, time delay two-step approach can also be extended, time delay two-step approach can be divided into again a time delay two-step approach and twice time delay two-step approach etc., a time delay two-step approach is on the basis of two-step approach flow process, increase reagent adding, mixing step and a primary first-order equation incubative time, and twice time delay two-step approach is on the basis of two-step approach flow process, increase by twice reagent adding, mixing step and twice reaction incubative time.The present invention can be easy to the reaction time realizing multiple test pattern and flexibility and changeability, also can support a time delay two-step approach and twice time delay two-step approach.
Except above testing process, above-mentioned automatic analysing apparatus 1 also can support the special testing processs such as sample automatic dilution.
In above-mentioned automatic analysing apparatus 1, buanch unit 5 can be divided into several to have the shift module of different motion track; And application of sample unit 6 also can be divided into several to have the application of sample module of different motion track.See following embodiment:
Embodiment two: shown in accompanying drawing 7, compared with the embodiment one shown in Fig. 1, difference is application of sample unit 6 and cleaning unit.The level run track of application of sample unit 6 is a straight line, can along horizontal linear guide rail movement and vertical up-or-down movement, level run track respectively with sample delivery unit 7, react incubation unit 2 and agent bin unit 8 is crossing.The tangential movement of application of sample unit 6 can improve positioning precision, also can complete machine be made compacter.Cleaning unit becomes at least one circle from individual pen, in the present embodiment, cleaning separative element 3 is inside and outside two circles, inner ring 3a completes cleaning separation and detection liquid dispensing, and outer ring 3b completes detection reaction, and such function divides more independent, the reaction of cleaning separation and detection is completed at the Internal and external cycle of cleaning separative element 3 respectively, temperature can be made to regulate more accurate, reduce influencing each other of cleaning separation and detection reaction, the detection reaction time that simultaneously more compact structure support can be utilized longer.Other unit is identical with the embodiment shown in Fig. 1 with control system 100.
The reaction process of embodiment two and method of testing are also basic similar with the first embodiment, and difference has been to clean and has been separated the flow process after entering detection reagent.Enter after detecting reagent, reaction vessel is transferred to outer ring from the inner ring of cleaning separative element 3 by buanch unit 5, and continue detection reaction in outer ring, after detection reaction completes, reaction vessel is transferred to inspection instrument position 4a by buanch unit 5 from outer ring again and carried out input.Certainly, also after cleaning is separated, reaction vessel can be transferred to outer ring, after outer ring enters detection reagent, continue detection reaction again.By buanch unit 5, reaction vessel is abandoned after detection completes.
Embodiment three: shown in accompanying drawing 8, compared with the embodiment two shown in Fig. 7, difference is buanch unit 5.It will be understood by those skilled in the art that to realize the present invention, buanch unit 5 can be made up of multiple shift module.In the present embodiment, buanch unit 5 is made up of the first shift module 501 and the second shift module 502, and the first shift module 501 and the second shift module 502 can level (rotating or straight line) and vertical movements.In this example, preferably the first shift module 501 horizontal revolving motion, the second shift module 502 rectilinear motion.The running orbit that horizontally rotates of the first shift module 501 abandons position 13, reaction vessel supply position 9a, the reaction vessel die circle cleaned on the outer inner ring of separative element 3, blending unit 11 and outer inner ring reaction vessel die react on incubation unit 2 respectively and justifies crossing with reaction vessel, the first shift module 501 is at these position of intersecting point transfer reaction containers.The linear running track of the second shift module 502 is respectively with detecting unit 4 with clean separative element 3 crossing, and the second shift module 502 is at detecting unit 4 and clean transfer reaction container between separative element 3.Compared with first two embodiment, buanch unit 5 is made up of multiple shift module, and multiple module can complete separately respective jump operation, can reduce the action frequency of each transfer part, reduce the life requirements of each parts, the transfer of reaction vessel also can be made more flexible.
Embodiment four: shown in accompanying drawing 9, compared with the embodiment one shown in Fig. 1, difference is at cleaning separative element 3, buanch unit 5, application of sample unit 6 and sample delivery unit 7 and blending unit 11.Cleaning unit and embodiment two are identical with in embodiment three, and be made up of inside and outside two circles, inner ring is for cleaning separation, and outer ring is used for detection reaction.Buanch unit 5 is similar with embodiment two, and buanch unit 5 is made up of the first shift module 503 and the second shift module 504, and the first shift module 503 and the second shift module 504 can level (rotating or straight line) and vertical movements.In this example, preferred levels rotary motion.The running orbit that horizontally rotates of the first shift module 503 abandons position 13, reaction vessel supply position 9a, the reaction vessel die circle cleaned on the outer inner ring of separative element 3, blending unit 11 and outer inner ring reaction vessel die react on incubation unit 2 respectively and justifies crossing with reaction vessel, the first shift module 503 is at these position of intersecting point transfer reaction containers.The running orbit of the second shift module 504 is crossing with the outer inner ring reaction vessel die circle reacted on incubation unit 2 with blending unit 11 respectively, and the second shift module 504 is transfer reaction container between blending unit 11 and reaction incubation unit 2.During concrete enforcement, blending unit 11 can be made up of multiple part, and in the present embodiment, blending unit 11 is made up of the first mixing module 1101 and the second mixing module 1102.Buanch unit 5 is made up of multiple shift module, and multiple module can complete separately respective jump operation, can reduce the action frequency of each transfer part, reduces the life requirements of each parts, and the transfer of reaction vessel also can be made more flexible.Blending unit 11 is made up of multiple, can realize high speed test, when after blending unit 11 fault, also can utilize another blending unit 11 that test is proceeded.
It will be understood by those skilled in the art that application of sample unit 6 can be made up of multiple application of sample module.In the present embodiment, application of sample unit 6 is made up of the first application of sample module 601, second application of sample module 602, the 3rd application of sample module 603.First application of sample module 601 is for the absorption of sample, discharge, and the second application of sample module 602 and the 3rd application of sample module 603 are for the absorption of reagent component, discharge.Application of sample unit 6 is made up of multiple module, and each module completes different functions, can improve feed rate, makes system test speed faster.
In the present embodiment, sample delivery unit 7 is transporting rail, can store and transmit multiple sample device 7a, sample device 7a have multiple sample tube.Sample delivery unit 7 adopts transporting rail mode, can increase the sample tube of accommodation, simultaneously also convenient operating personnel's operation.Other unit of the present embodiment is identical with the first embodiment with control system 100.
Testing process and method and the first embodiment difference are that the absorption and discharging of sample and reagent is completed by multiple application of sample module respectively, mixing is completed by optional multiple blending unit 11, also can be completed by multiple, the reaction of cleaning separation and detection completes at Internal and external cycle respectively, certainly also can enclose by one.Other flow process and method and the first embodiment similar.
Above-described embodiment, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalences done according to Spirit Essence of the present invention change or modify, and all should be encompassed within protection scope of the present invention.

Claims (19)

1. an automatic analysing apparatus, is characterized in that: it comprises
Reaction vessel feed unit, is placed with some reaction vessels in described reaction vessel feed unit;
Agent bin unit, have several in described agent bin unit and place the reagent position filling the reagent container of analytical reagent, and described agent bin unit has absorption reagent sites, the reagent position described in each all can move to described absorption reagent sites;
Sample delivery unit, described sample delivery unit is provided with several and places the sample position filling the sample container of analyzing samples, and described sample delivery unit has absorption sample position;
Reaction incubation unit, described reaction incubation unit comprises the reaction vessel position that several carry out reacting incubation, and described reaction incubation unit has transfer port and stock layout position, the reaction vessel position described in each all can move to described transfer port or described stock layout position;
Cleaning separative element, is provided with several cleanings and point offs normal, and described cleaning separative element has cleaning transferring position in described cleaning separative element, and the cleaning described in each divides to off normal and all can move to described cleaning transferring position;
Detecting unit, the pick-up unit that described detecting unit comprises several detection reaction incubation positions of carrying out detection reaction, detects the reaction product after detection reaction, described detecting unit has detection position and detects transferring position, described pick-up unit is corresponding with described detection position, and the reaction vessel on the detection reaction incubation position described in each all can shift or move to described detection transferring position or/and described detection position;
Application of sample unit, described application of sample unit can move and can draw and discharge described analyzing samples and/or described analytical reagent in described automatic analysing apparatus, and described absorption reagent sites, described absorption sample position, described stock layout position are all positioned on the motion track of described application of sample unit;
Buanch unit, described buanch unit can move and can shift described reaction vessel in described automatic analysing apparatus, and described reaction vessel shifts by described buanch unit between described reaction vessel feed unit, described reaction member, described cleaning separative element, described detecting unit;
Control system, described control system is connected with described reaction vessel feed unit, described agent bin unit, described sample delivery unit, described reaction incubation unit, described cleaning separative element, described detecting unit, described application of sample unit, described buanch unit respectively and controls the movement of above-mentioned each unit or state.
2. automatic analysing apparatus according to claim 1, is characterized in that: described automatic analysing apparatus also comprises blending unit, on the motion track that described blending unit is arranged in described buanch unit or be integrated in described reaction incubation unit.
3. automatic analysing apparatus according to claim 1, it is characterized in that: described automatic analysing apparatus also comprises reaction vessel recovery area, described reaction vessel recovery area has reaction vessel and abandons position, and described reaction vessel abandons position and is positioned on the motion track of described buanch unit.
4. the automatic analysing apparatus according to claim 1 or 2 or 3, it is characterized in that: described agent bin unit is the rotary-disk type structure comprising agent bin rotating disk, described reagent position be multi-turn annular distribution on described agent bin rotating disk, described reagent position has and to be connected with described control system and to drive the free-wheeling system of its rotation.
5. the automatic analysing apparatus according to claim 1 or 2 or 3, it is characterized in that: be provided with several adapters in described agent bin unit, described reagent position is positioned on described adapter and the reagent position each described adapter had described in several.
6. automatic analysing apparatus according to claim 1, is characterized in that: described agent bin unit also comprises the refrigerating plant making it be in frozen state.
7. the automatic analysing apparatus according to claim 1 or 2 or 3, it is characterized in that: described sample delivery unit is comprise the rotary-disk type structure of sample rotating disk or comprise the rail mounted structure of path, described sample position is that multi-turn annular distribution is on described sample rotating disk; Be provided with several sample racks in described sample delivery unit, described sample position is positioned on described sample rack and the sample position each described sample rack had described in several.
8. the automatic analysing apparatus according to claim 1 or 2 or 3, it is characterized in that: described reaction incubation unit is comprise the rail mounted structure of reaction rail or comprise the rotary-disk type structure of reaction rotating disk, and described reaction vessel position is positioned on described reaction rail or described reaction rotating disk.
9. automatic analysing apparatus according to claim 8, is characterized in that: described reaction vessel position is that multi-turn annular distribution is on described reaction rotating disk.
10. automatic analysing apparatus according to claim 8, is characterized in that: be also provided with in described reaction incubation unit and be connected with described control system and make the reaction thermostatic control system of temperature stabilization in described reaction incubation unit.
11. automatic analysing apparatus according to claim 1 or 2 or 3, it is characterized in that: described cleaning separative element is comprise the rail mounted structure of cleaning track or comprise the rotary-disk type structure of cleaning rotating disk, and described cleaning separative element also comprises the magnetic collecting mechanism, mixing mechanism, mechanism for filling liquid and the liquid sucting mechanism that produce magnetic field.
12. automatic analysing apparatus according to claim 1, is characterized in that: be provided with in described cleaning separative element and be connected with described control system system and make the cleaning thermostatic control system of temperature stabilization in described cleaning separative element.
13. automatic analysing apparatus according to claim 1 or 2 or 3, is characterized in that: the detection reaction incubation position of described detecting unit is integrated in described cleaning separative element or is arranged at independently to be detected on incubation rotating disk.
14. automatic analysing apparatus according to claim 11, is characterized in that: on described cleaning rotating disk the cleaning comprised described at least one circle divide off normal, detection reaction incubation position described at least one circle.
15. automatic analysing apparatus according to any one of claim 1 to 3, is characterized in that: described buanch unit comprises the shift module that several have different motion track.
16. automatic analysing apparatus according to any one of claim 1 to 3, is characterized in that: described application of sample unit comprises the application of sample module that several have different motion track.
17. automatic analysing apparatus according to any one of claim 1 to 3, is characterized in that: described control system comprises man-machine interaction unit, the control module be connected with described man-machine interaction unit, the temperature regulation section that is connected with described control module are divided and motion control portion and other control sections, the storage unit be connected with described control module with described man-machine interaction unit respectively and data processing unit; Described reaction vessel feed unit, described agent bin unit, described sample delivery unit, described reaction incubation unit, described cleaning separative element, described application of sample unit, described buanch unit are connected with described motion control portion respectively, described agent bin unit, described reaction incubation unit, described cleaning separative element, described detecting unit divide with described temperature regulation section respectively and are connected, and described detecting unit is connected with described data processing unit.
18. 1 kinds of automatic analysis methods utilizing automatic analysing apparatus as claimed in claim 1 to carry out, is characterized in that: the method comprises:
(1) supply: by described reaction vessel feed unit supply response container, by described buanch unit, described reaction vessel is transferred to the transfer port of described reaction incubation unit, more described reaction vessel is moved to the stock layout position of described reaction incubation unit by described reaction incubation unit;
(2) application of sample: described application of sample unit draws described analyzing samples in the absorption sample position of described sample delivery unit, described analyzing samples is expelled in described reaction vessel by the stock layout position moving to described reaction incubation unit; After described application of sample unit draws described analytical reagent on the absorption reagent sites of described agent bin unit, described analytical reagent is expelled in described reaction vessel by the stock layout position moving to described reaction incubation unit;
(3) react: the described analyzing samples in described reaction vessel and described analytical reagent are reacted in described reaction incubation unit;
(4) clean: the cleaning transferring position by the transfer port of described reaction incubation unit, described reaction vessel being transferred to described cleaning separative element by described buanch unit, and move described reaction vessel to described cleaning by described cleaning separative element and divide to off normal cleaning separation is carried out to described potpourri wherein;
(5) add detection reagent: described detection reaction incubation position to through described cleaning be separated after described in reaction vessel in add detection reagent;
(6) detection reaction: carry out detection reaction in described detection reaction incubation position;
(7) detect: by described buanch unit, the reaction vessel described in after detection reaction is shifted out described detection reaction incubation position from described detection transferring position, shifted by described buanch unit or described detecting unit again or move to the detection position of described detecting unit, by described pick-up unit, the potpourri in described reaction vessel being detected.
19. automatic analysis methods according to claim 18, is characterized in that: after the analyzing samples described in discharging and described analytical reagent to described reaction vessel, also comprise and being mixed by the potpourri in described reaction vessel.
CN201310324968.5A 2013-07-30 2013-07-30 Automatic analysis apparatus and automatic analysis method Pending CN104345158A (en)

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Application publication date: 20150211