CN107252793B - Disc type cleaning device for analyzer - Google Patents
Disc type cleaning device for analyzer Download PDFInfo
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- CN107252793B CN107252793B CN201710498780.0A CN201710498780A CN107252793B CN 107252793 B CN107252793 B CN 107252793B CN 201710498780 A CN201710498780 A CN 201710498780A CN 107252793 B CN107252793 B CN 107252793B
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- magnetic pole
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
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Abstract
The invention relates to a disc type cleaning device of an analyzer, which attracts magnetic beads in a reaction cup through magnetic pole pairs positioned on two sides of a plurality of reaction cup running grooves, so that the magnetic beads are positioned on the front wall and the rear wall of the reaction cup, and the magnetic beads in the reaction cup cannot be attracted when being inserted into a liquid suction and injection needle in the reaction cup for sucking liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup move through the change of the magnetic poles to the N-S poles, so that the magnetic beads are further fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Description
Technical Field
The invention relates to a disc type cleaning device for an analyzer, and belongs to the technical field of medical instruments.
Background
Chemiluminescence immunoassay (CLIA) is a detection and analysis technique for various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and high specificity immunoreaction. It is usually necessary to coat specific biological materials on magnetic beads, and then add a luminescent solution to collect the luminescence intensity for quantitative analysis of the detection object.
The disc type cleaning device of the analyzer is manufactured for realizing continuous measurement, the reaction cup is cleaned for many times on a rotating disc, so that specific biological raw materials which are not coated on magnetic beads are cleaned, the cleaning effect of the disc type cleaning device of the existing analyzer is poor, the magnetic beads are easily taken away by cleaning liquid, and the accuracy of measurement is influenced.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: in order to overcome the problems, the disc type cleaning device for the analyzer is better in cleaning effect.
The technical scheme adopted by the invention for solving the technical problem is as follows:
the invention provides a disc type cleaning device for an analyzer, which comprises a cleaning disc mechanism, a liquid suction and injection mechanism and a shaking mechanism, wherein the liquid suction and injection mechanism comprises a liquid suction disc and a liquid suction disc;
the cleaning disc mechanism includes:
a cylinder having a circular reaction cup running groove;
the disc is rotationally arranged in the cylinder, a circle of reaction cup accommodating holes are arranged on the disc in an equal diameter manner, and the reaction cups can be placed in the reaction cup accommodating holes;
the magnetic pole groups are arranged in the cylinder in sequence along the running direction of the reaction cup, each magnetic pole group is composed of magnetic pole pairs positioned on two sides of the reaction cup running grooves, each magnetic pole group is at least provided with two magnetic pole pairs positioned on two sides of the reaction cup running grooves, the magnetic pole directions of the magnets in each magnetic pole pair in each magnetic pole group except the last magnetic pole group are the same, the magnetic pole directions of the adjacent two magnetic pole pairs are opposite, the magnetic pole directions of the magnets in each magnetic pole pair in the last magnetic pole group are the same or different, and the setting heights of the magnetic pole pairs are gradually reduced;
a liquid absorption and injection needle of the liquid absorption and injection mechanism can extend into the reaction cup at the position corresponding to the last magnetic pole pair of each magnetic pole group when liquid absorption and injection are needed;
the shaking up mechanism is positioned between the two magnetic pole groups.
Preferably, in the analyzer disk cleaning device of the present invention, the height of the latter pole pair in the last pole group is reduced by 5-8mm compared to the former pole pair.
Preferably, the analyzer disk cleaning device of the present invention, the shaking mechanism comprises: the device comprises a lifting driving piece, a lifting plate, a shaking driving piece fixed at the bottom of a cylinder, a rocker connected with the shaking driving piece through a coupler, an eccentric cup arranged at the top of the rocker, an elastic piece fixed on the cylinder and extending into the top of a disc, a cover wheel arranged on the elastic piece and used for covering the top of a reaction cup, a circular wheel capable of extending into the reaction cup, wherein the central axis of the eccentric cup is not collinear with the central axis of the rocker, when the reaction cup is shaken uniformly, the lifting plate is driven by the lifting driving piece to lift up the shaking driving piece, the rocker and the eccentric cup lift up along with the lifting plate, the eccentric cup jacks up the reaction cup, the top of the reaction cup is abutted against the cover wheel of the elastic piece, the reaction cup is fixed, then the shaking driving piece is started, the reaction cup is shaken through the eccentric cup to shake liquid in the reaction cup uniformly, a silicon rubber layer is arranged at the bottom of the cover wheel, and when the shaking driving piece, the reaction cup rotates 8-15s at the speed of 600-1200 rpm in one direction.
Preferably, in the analyzer disk type cleaning device, the distance between the central axis of the eccentric cup and the central axis of the rocker is 1/4-1/5 of the width of the reaction cup.
Preferably, the analyzer disk type cleaning device and the eccentric cup of the shaking mechanism in front of the last magnetic pole group have magnetism, and the magnetic poles are positioned at the top end and the bottom end.
Preferably, in the disk type cleaning device for an analyzer of the present invention, the liquid suction and injection needle of the liquid suction and injection mechanism can extend into the reaction cup at the position corresponding to the last magnetic pole pair of each magnetic pole group when liquid suction and injection are required, and after the liquid suction and injection are completed, the liquid suction and injection needle is taken out, except for the last liquid suction and injection needle, the remaining liquid suction and injection needles all have the functions of liquid suction and injection, and the last liquid suction and injection needle only has the function of liquid suction.
The invention has the beneficial effects that: the disc type cleaning device of the analyzer attracts the magnetic beads in the reaction cup through the magnetic pole pairs positioned on the two sides of the running grooves of the reaction cup, so that the magnetic beads are positioned on the front wall and the rear wall of the reaction cup, and the magnetic beads in the reaction cup cannot be attracted when the magnetic beads are inserted into the liquid suction and injection needle in the reaction cup for sucking liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup move through the change of the magnetic poles to the N-S poles, so that the magnetic beads are further fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a perspective view of one embodiment of a reagent washing apparatus for an analyzer according to the present invention;
FIG. 2 is a schematic view of the magnetic pole arrangement on the disk of the present invention;
FIG. 3 is a perspective view of one embodiment of a cleaning disc mechanism of the present invention;
FIG. 4 is a perspective view of one embodiment of a shake-up mechanism of the present invention.
The reference signs are:
1-cylinder; 11-a reaction cup running groove; 2-a disc; 3-shaking up the mechanism; 310-shaking up the driving member; 311-rocker; 321-an elastic sheet; 322-cover wheel; 330-eccentric cup; 900-reaction cup.
Detailed Description
The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic views illustrating only the basic structure of the present invention in a schematic manner, and thus show only the constitution related to the present invention.
Example 1
The present embodiment provides an analyzer tray cleaning apparatus, as shown in fig. 1:
a cleaning disc mechanism, a liquid suction and injection mechanism and a shaking mechanism 3;
the cleaning disc mechanism includes:
a cylinder 1 having a circular reaction cup running groove 11;
the disc 2 is rotatably arranged in the cylinder 1, a circle of reaction cup accommodating holes are arranged on the disc 2 in an equal diameter mode, and the reaction cups 900 can be placed in the reaction cup accommodating holes;
<xnotran> , 1 900 ( 1 6 , ), 11 , 11 , , ( N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N), , 5-8mm; </xnotran>
Shake even mechanism 3, lie in between two magnetic pole groups, include: a lifting driving part, a lifting plate, a shaking driving part 310 fixed at the bottom of the cylinder 1, a rocker 311 connected with the shaking driving part 310 through a coupling, an eccentric cup 330 arranged at the top of the rocker 311, an elastic sheet 321 fixed on the cylinder 1 and extending into the top of the disc 2, a cover wheel 322 arranged on the elastic sheet 321 and used for covering the top of the reaction cup 900, a round wheel capable of extending into the reaction cup 900 is arranged at the bottom of the cover wheel 322, the central axis of the eccentric cup 330 is not collinear with the central axis of the rocker 311, the distance between the central axis of the eccentric cup 330 and the central axis of the rocker 311 is 1/8 to 1/4 of the width of the reaction cup 900 (the distance is 2-2.5mm when the width of the reaction cup 900 is 1cm, otherwise, the liquid in the reaction cup 900 overflows due to large shaking amplitude), when the reaction cup 900 is shaken uniformly, the lifting plate is driven to rise by the lifting driving part, the shaking driving part 310, the rocker 311 and the eccentric cup 330 rise along with the lifting plate, the reaction cup 900 is jacked up by the eccentric cup 330 (the reaction cup 900 is not limited by the reaction cup accommodating hole 121), the top of the reaction cup 900 is propped against the cover wheel 322 of the elastic sheet 321, the reaction cup 900 is fixed, then the shaking uniform driving part 310 is started, the reaction cup 900 is shaken by the eccentric cup 330, the liquid in the reaction cup 900 is shaken uniformly, the bottom of the cover wheel 322 is provided with a silicon rubber layer, and when the shaking uniform driving part 310 rotates the reaction cup 900 to one direction for 10 to 15 seconds at the speed of 800 to 1200 revolutions per minute;
all magnets are neodymium boron iron magnets.
The eccentric cup 330 of the shaking mechanism 3 in front of the last magnetic pole group has magnetism, and the magnetic poles are positioned at the top and bottom ends.
The imbibition of mechanism is annotated liquid needle 4 can stretch into the reaction cup 900 on the position that every magnetic pole group last magnetic pole pair corresponds when needs imbibition and notes liquid, and imbibition and notes liquid are after finishing, annotate liquid needle 4 with the imbibition again and take out, except last imbibition notes liquid needle 4, remaining imbibition notes liquid needle 4 all has the function of imbibition and notes liquid, and last imbibition notes liquid needle 4 only has the function of imbibition.
In the disk type cleaning device for an analyzer of this embodiment, the magnetic beads in the cuvette 900 are attracted by the pairs of magnetic poles located on both sides of the plurality of cuvette running grooves 11, and the magnetic beads are located on the front and rear walls of the cuvette 900, so that the magnetic beads in the cuvette 900 are not attracted when the pipette-injecting needles 4 inserted into the cuvette 900 suck liquid. Meanwhile, the magnetic beads in the liquid-absorbing gap reaction cup 900 are moved by the change of the magnetic poles to the N-S poles, so that the magnetic beads are further fully contacted with the cleaning liquid, and the reagents which are not adhered to the surfaces of the magnetic beads are washed away.
Example 2
This embodiment provides an analysis appearance reagent storehouse body structure, as shown in fig. 1:
<xnotran> 1 , ( S-N, S-N, S-N, S-N; N-S, N-S, N-S, N-S; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N; N-S, N-S, S-N, S-N), , 5-8mm. </xnotran>
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (4)
1. The disc type cleaning device of the analyzer is characterized by comprising a cleaning disc mechanism, a liquid suction and injection mechanism and a shaking mechanism (3);
the cleaning disc mechanism includes:
a cylinder (1) having a circular reaction cup running groove (11);
the disc (2) is rotationally arranged in the cylinder (1), a circle of reaction cup accommodating holes are formed in the disc (2) in an equal-diameter mode, and the reaction cups (900) can be placed in the reaction cup accommodating holes;
a plurality of magnetic pole groups which are arranged in the cylinder (1) and are sequentially arranged along the running direction of the reaction cup (900), each magnetic pole group is composed of magnetic pole pairs positioned at two sides of a plurality of reaction cup running grooves (11), each magnetic pole group is at least provided with two magnetic pole pairs positioned at two sides of the reaction cup running grooves (11), the magnetic pole directions of the magnets in each magnetic pole pair in each magnetic pole group except the last magnetic pole group are the same, the magnetic pole directions of two adjacent magnetic pole pairs are opposite, the magnetic pole directions of the magnets in each magnetic pole pair in the last magnetic pole group are the same or different, the setting heights of the magnetic pole pairs are gradually reduced, and the height of the next magnetic pole pair in the last magnetic pole group is reduced by 5-8mm compared with the previous magnetic pole pair;
a liquid suction and injection needle (4) of the liquid suction and injection mechanism can extend into the reaction cup (900) at the position corresponding to the last magnetic pole pair of each magnetic pole group when liquid suction and injection are needed;
the shaking mechanism (3) is positioned between the two magnetic pole groups;
shake even mechanism (3) and include: a lifting driving piece, a lifting plate, a shaking uniformly driving piece (310) fixed at the bottom of the cylinder (1), a rocker (311) connected with the shaking uniformly driving part (310) through a coupler, an eccentric cup (330) arranged at the top of the rocker (311), an elastic sheet (321) fixed on the cylinder (1) and extending into the top of the disc (2), a cover wheel (322) used for covering the top of the reaction cup (900) is arranged on the elastic sheet (321), a round wheel capable of extending into the reaction cup (900) is arranged at the bottom of the cover wheel (322), the central axis of the eccentric cup (330) is not collinear with the central axis of the rocker (311), when the reaction cup (900) is shaken up, the lifting driving piece drives the lifting plate to rise, the shaking driving piece (310), the rocker (311) and the eccentric cup (330) rise along with the lifting plate, the eccentric cup (330) jacks up the reaction cup (900), the top of the reaction cup (900) is propped against the cover wheel (322) of the elastic sheet (321), the reaction cup (900) is fixed, then the shaking driving piece (310) is started, the reaction cup (900) is shaken by the eccentric cup (330), so that the liquid in the reaction cup (900) is shaken uniformly, the silicon rubber layer is arranged at the bottom of the cover wheel (322), when the liquid is shaken uniformly, shaking the driving member (310) to make the reaction cup (900) rotate in one direction at the speed of 600-1200 rpm for 8-15s.
2. The analyzer disk cleaning apparatus of claim 1 wherein the central axis of the eccentric cup (330) is spaced from the central axis of the rocker (311) by a distance of 1/8 to 1/4 of the width of the reaction cup (900).
3. The analyzer disk cleaning apparatus according to claim 2, wherein the eccentric cup (330) of the shaking mechanism (3) in front of the last pole group is magnetic, and the poles are located at the top and bottom ends.
4. The analyzer disk cleaning apparatus according to any one of claims 1 to 3, wherein the aspirating and injecting needle (4) is removed after the aspiration and injecting are completed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498780.0A CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710498780.0A CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
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| Publication Number | Publication Date |
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| CN107252793A CN107252793A (en) | 2017-10-17 |
| CN107252793B true CN107252793B (en) | 2023-04-07 |
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| CN201710498780.0A Active CN107252793B (en) | 2017-06-27 | 2017-06-27 | Disc type cleaning device for analyzer |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108169309B (en) * | 2017-12-14 | 2019-11-22 | 安徽九陆生物科技有限公司 | A kind of rotating disc type measuring cup carrier mechanism and its application method |
| CN110082549B (en) * | 2018-01-25 | 2023-10-10 | 深圳市新产业生物医学工程股份有限公司 | Cleaning device and chemiluminescence detector |
| CN109655627B (en) * | 2018-12-17 | 2024-06-25 | 宁波海壹生物科技有限公司 | Belt cleaning device of function is hatched in area |
| CN112296049B (en) * | 2019-07-26 | 2022-04-05 | 深圳迎凯生物科技有限公司 | Cleaning method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN203426088U (en) * | 2013-08-22 | 2014-02-12 | 钟伟明 | Magnetic bead washing device |
| CN103599898B (en) * | 2013-10-29 | 2015-11-25 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device |
| CN203764601U (en) * | 2014-04-11 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Magnetic microsphere cleaning device used for fully automatic chemiluminescence immunity analyzer |
| CN105891113A (en) * | 2014-12-16 | 2016-08-24 | 合肥运涛光电科技有限公司 | Reaction vessel for luminescence tester and cleaning and separating mechanism thereof |
| CN104655831A (en) * | 2015-03-04 | 2015-05-27 | 哈尔滨工业大学（威海） | Magnetic bead cleaning and separating device for full-automatic chemical luminescence immunity analyzer |
| CN207154285U (en) * | 2017-06-27 | 2018-03-30 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer disc type cleaning device |
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