CN109433686A - Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
- Publication number
- CN109433686A CN109433686A CN201811611882.XA CN201811611882A CN109433686A CN 109433686 A CN109433686 A CN 109433686A CN 201811611882 A CN201811611882 A CN 201811611882A CN 109433686 A CN109433686 A CN 109433686A
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- Prior art keywords
- reaction cup
- magnetic bead
- magnet
- cleaning device
- station
- Prior art date
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- 239000011324 bead Substances 0.000 title claims abstract description 89
- 238000004140 cleaning Methods 0.000 title claims abstract description 87
- 238000003018 immunoassay Methods 0.000 title claims abstract description 17
- 238000004458 analytical method Methods 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 109
- 238000005406 washing Methods 0.000 claims abstract description 74
- 230000000712 assembly Effects 0.000 claims abstract description 22
- 238000000429 assembly Methods 0.000 claims abstract description 22
- 238000010521 absorption reaction Methods 0.000 claims description 20
- 238000009434 installation Methods 0.000 claims description 19
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 230000009471 action Effects 0.000 claims description 5
- 230000004308 accommodation Effects 0.000 claims description 4
- 239000000243 solution Substances 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000002516 radical scavenger Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910000828 alnico Inorganic materials 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
Abstract
The present invention relates to a kind of magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meters.The magnetic bead cleaning device includes reaction cup conveying assembly, clean needle assemblies, magnet assemblies and at least two washing stations, reaction cup conveying assembly is for conveying reaction cup, so that the reaction cup moves between the different washing stations, the cleaning needle assemblies are used to inject cleaning solution into the reaction cup and draw cleaning solution from the reaction cup, the magnet assemblies include the magnet corresponding to each washing station setting, the magnetic bead in the reaction cup can be adsorbed in the wall of cup of the reaction cup by the magnet, and magnet corresponding to the adjacent washing station of any two is located at the two sides of the transport path of the reaction cup.Magnetic bead cleaning device of the invention enables to the magnetic bead being wrapped in magnetic bead group adequately to be cleaned.
Description
Technical field
The present invention relates to in-vitro diagnosis medical instruments field more particularly to a kind of magnetic bead cleaning device and have the magnetic bead clear
The Full-automatic chemiluminescence immunoassay analysis meter of cleaning device.
Background technique
Full-automatic chemiluminescence immunoassay analysis meter is that one kind can carry out immunology quantitative analysis to the body fluid sample of patient
Instrument can examine anaemia, cardiovascular disease, congenital disorders, sex hormone, infectious disease, metabolic function, tumor markers, first shape
Gland etc. and therapeutic agent is monitored.The application of Full-automatic chemiluminescence immunoassay analysis meter, fully achieves checkout procedure
Automation, improves the working efficiency of immunoassay, eliminates artificial subjective error, stabilize the quality of immunity inspection, be
Clinical immunoassays provide a reliable and efficient approach.
In using Full-automatic chemiluminescence immunoassay analysis meter of the magnetic bead as reaction carriers, multiple one are usually used simultaneously
Secondary property reaction cup is as reaction vessel.These reaction cups are arranged in around disk at each interval.Multiple reaction cups are set
Purpose is that the differential responses behaviour of the sample of different people can be unfolded inside different reaction cups simultaneously in order to improve analysis efficiency
Make.When work, mechanical arm is added into reaction cup needs the body fluid sample analyzed, containing the micron for being adsorbed with antigen or antibody
Or the reaction reagent of nanoscale magnetic bead.Magnetic bead in reagent is suspended in reagent.It is completed in the incubation reaction of sample and reagent
Afterwards, need to clean magnetic bead, remove unreacted body fluid sample and reagent, leave behind reaction after using magnetic bead as solid phase
The compound of carrier.
In cleaning, by rotating circular disc, so that reaction cup to be cleaned is gone to below wiper mechanism, and in wiper mechanism
Be provided opposite to permanent magnet, permanent magnet is by magnetic fields, so that magnetic bead is moved to permanent magnet direction, finally by reaction cup
Wall of cup stops, and is attached to reaction cup on the inside of the wall of cup of permanent magnet side.It is at this time that the aspirating needle on wiper mechanism is mobile
To reaction cup bottom, including that all liq including liquid sample and unreacted reagent is taken out in reaction cup.Due to magnetic
Pearl solid phase carrier is attracted on wall of cup, will not be pulled away.Later, wiper mechanism passes through injection needle again and injects into reaction cup clearly
Washing lotion, the compound to magnetic bead as solid phase carrier clean.Cleaning solution is extracted out later, after multiplicating, is completed entire
Cleaning process.
But the prior art has the following deficiencies:
(1) when being cleaned to Myoglobin carrier, since it is attached on wall of cup, it is difficult to in addition to magnetic bead group
Other magnetic beads outside surface are adequately cleaned, and cause to clean insufficient.
(2) magnetic bead is suspended in liquid, even if entire adsorption process is usually also required to count under the magnetic fields of permanent magnet
Ten seconds, it greatly affected working efficiency.
Summary of the invention
In view of drawbacks described above in the prior art, the purpose of the present invention is to provide a kind of magnetic beads for fully cleaning magnetic bead
Cleaning device and Full-automatic chemiluminescence immunoassay analysis meter with the magnetic bead cleaning device.
For this purpose, the present invention provides the following technical solutions.
The present invention provides a kind of magnetic bead cleaning device, the magnetic bead cleaning device includes reaction cup conveying assembly, cleaning
Needle assemblies, magnet assemblies and at least two washing stations,
The reaction cup conveying assembly for conveying reaction cup so that the reaction cup the different washing stations it
Between move,
The cleaning needle assemblies are used to inject cleaning solution into the reaction cup and draw cleaning solution from the reaction cup,
The magnet assemblies include the magnet corresponding to each washing station setting, the magnet can will it is described instead
The magnetic bead in cup is answered to be adsorbed in the wall of cup of the reaction cup, and
In any two adjacent washing stations, the magnet position corresponding to one of them described washing station
In the side of the transport path of the reaction cup, the magnet corresponding to another described washing station is located at the reaction cup
Transport path the other side.
In at least one embodiment, when the corresponding magnet of the two neighboring washing station acts on the magnetic bead,
The magnetic bead is opposite relative to the moving direction of the reaction cup.
In at least one embodiment, the magnetic bead cleaning device further includes pre- absorption station,
The magnet assemblies include the pre- adsorption magnet corresponding to the pre- absorption station setting, the pre- adsorption magnet energy
Enough magnetic beads by the reaction cup for being located at the pre- absorption station are adsorbed in the wall of cup of the reaction cup,
The pre- adsorption magnet magnet corresponding with first washing station is located at the transport path of the reaction cup
The same side.
In at least one embodiment, the magnet assemblies include magnet mounting base, each washing station and institute
It states pre- absorption station and is provided with the magnet mounting base, the magnet mounting base includes the transport path positioned at the reaction cup
Two sides installation chamber, the magnet is installed on one of them described installation chamber.
In at least one embodiment, the reaction cup conveying assembly includes fixed part and moving portion, the fixed part
It is formed with the delivery chute mobile for the reaction cup, the moving portion is provided with the receiving portion for accommodating the reaction cup, institute
Stating moving portion can move in the delivery chute with the reaction cup.
In at least one embodiment, the delivery chute is in circular ring shape.
In at least one embodiment, described accommodation section has multiple, between the adjacent described accommodation section of any two
Spacing between spacing and the adjacent washing station of any two is equal, and with first washing station with it is described
Spacing between pre- absorption station is equal.
In at least one embodiment, the magnet is permanent magnet.
In at least one embodiment, the quantity of the washing station is three to six.
The present invention also provides a kind of Full-automatic chemiluminescence immunoassay analysis meter, the automatic chemiluminescence immunoassay
Instrument includes magnetic bead cleaning device described in any of the above-described embodiment.
By using above-mentioned technical solution, the present invention provides a kind of magnetic bead cleaning devices, clear at least two
Station is washed, by being alternately distributed the magnet for corresponding to each washing station setting in the two sides of reaction cup transport path, so that instead
When cup being answered to convert washing station, magnetic bead can be moved to and the wall surface phase under the magneticaction of magnet from a wall surface of reaction cup
Pair wall surface, during the motion, magnetic bead group can be broken up so that the magnetic bead being wrapped in magnetic bead group obtain it is adequately clear
It washes.Similarly, the Full-automatic chemiluminescence immunoassay analysis meter for having the magnetic bead cleaning device has same beneficial effect.
Detailed description of the invention
Fig. 1 shows the three-dimensional structure diagram of magnetic bead cleaning device according to the present invention.
Fig. 2 shows the top views of Fig. 1.
Fig. 3 shows the partial enlarged view at the position A of Fig. 2.
Fig. 4 shows the magnet mounting base of the first washing station in Fig. 1 and the structure chart of magnet.
Fig. 5 shows the cross-sectional view of Fig. 4.
Fig. 6 shows the magnet mounting base of the second washing station in Fig. 1 and the structure chart of magnet.
Fig. 7 shows the cross-sectional view of Fig. 6.
Description of symbols
1 reaction cup conveying assembly；11 fixed parts；111 delivery chutes；
2 cleaning needle assemblies；21 cleaning punch blocks；22 cleaning needles；
3 magnet assemblies；31 magnet mounting bases；311 first installation chambers；312 second installation chambers；313 groove portions；32 magnetic
Iron；
4 washing stations；41 first washing stations；42 second washing stations；43 third washing stations；44 the 4th scavengers
Position；
5 pre- absorption stations；6 reaction cups.
Specific embodiment
Exemplary embodiments of the present invention are described with reference to the accompanying drawings.It should be appreciated that these specific descriptions are only used for
How teaching those skilled in the art implement the present invention, rather than all feasible modes that exhaustion is of the invention, without in
It limits the scope of the invention.
The specific embodiment of magnetic bead cleaning device according to the present invention is described in detail below with reference to Fig. 1 to Fig. 7.
In the present embodiment, as depicted in figs. 1 and 2, magnetic bead cleaning device includes reaction cup conveying assembly 1, cleaning needle
Component 2, magnet assemblies 3, washing station 4 and pre- absorption station 5.Wherein, reaction cup conveying assembly 1 makes for conveying reaction cup 6
Reaction cup 6 moves between different washing stations 4, cleaning needle assemblies 2 are used to inject cleaning solution into reaction cup 6 and from anti-
It answers in cup 6 and draws cleaning solution.
In the present embodiment, as shown in Figure 1, reaction cup conveying assembly 1 includes fixed part 11 and moving portion.Wherein, it moves
The receiving portion for accommodating reaction cup 6 is provided in dynamic portion.
In the present embodiment, fixed part 11 is formed with delivery chute 111, and moving portion can be with reaction cup 6 in delivery chute
It is moved in 111.Wherein, delivery chute 111 is in circular ring shape.
In the present embodiment, fixed part 11 is whole substantially annular in shape.
In the present embodiment, cleaning needle assemblies 2 include cleaning punch block 21 and cleaning needle 22.Wherein, cleaning needle 22 is installed
In on cleaning punch block 21.
Cleaning needle 22 generally comprises the injection needle for injecting cleaning solution into reaction cup 6 and draws cleaning solution from reaction cup 6
Aspirating needle, cleaning needle assemblies 2 can use existing structure, details are not described herein again for detailed construction.
In the present embodiment, as shown in figure 3, magnet assemblies 3 include the magnet installation that corresponding each washing station 4 is arranged
Seat 31 and magnet 32.Wherein, magnet mounting base 31 is fixedly installed in fixed part 11.
In the present embodiment, as shown in Figure 4 and Figure 5, magnet mounting base 31 includes that the first installation chamber 311, second is pacified
It behave affectedly room 312 and groove portion 313.Wherein, the first installation chamber 311 and the second installation chamber 312 are oppositely arranged, and are formed among the two
Groove portion 313.
In the present embodiment, one of the first installation chamber 311 and the second installation chamber 312 are equipped with magnet 32.
In the present embodiment, when reaction cup 6 is located at washing station 4, reaction cup 6 is located in groove portion 313.In this way, magnetic
Magnetic bead in reaction cup 6 can be effectively adsorbed on the wall of cup of reaction cup 6 by iron 32.
In the present embodiment, as shown in figure 3, there are four washing stations 4, respectively the first washing station 41, second is clear
Wash station 42, third washing station 43 and the 4th washing station 44.Reaction cup 6 can successively pass through when moving in delivery chute 111
First washing station 41, the second washing station 42, third washing station 43 and the 4th washing station 44.
In the present embodiment, magnet 32 corresponding to adjacent washing station 4 is respectively arranged at the conveying path of reaction cup 6
The two sides of diameter (i.e. delivery chute 111).That is, as shown in figure 3, the magnetic that corresponding first washing station 41 and third washing station 43 are arranged
Iron 32 is set in the first installation chamber 311, and the magnet 32 of corresponding second washing station 42 and the setting of the 4th washing station 44 is set
It is placed in the second installation chamber 312.
In the present embodiment, when the corresponding magnet 32 of two neighboring washing station 4 acts on magnetic bead, magnetic bead is relative to anti-
Answer the moving direction of cup 6 opposite.For example, magnetic bead under the action of the first 41 corresponding magnet 32 of washing station, in reaction cup 6
It is mobile away from the center of circle of delivery chute 111 (or fixed part 11) along the radial direction of delivery chute 111 (or fixed part 11), in the second cleaning
Under the action of the corresponding magnet 32 of station 42, magnetic bead being radially orientated along delivery chute 111 (or fixed part 11) in reaction cup 6
The center of circle of delivery chute 111 (or fixed part 11) is mobile.In this way, magnetic bead group can preferably be broken up, so that magnetic bead cleaning is more abundant.
In the present embodiment, reaction cup 6 has multiple, and multiple reaction cups 6 are evenly arranged in moving portion.
In the present embodiment, spacing (that is, any two adjacent receiving portion of the adjacent reaction cup 6 of any two
Spacing) it is equal to the spacing of the adjacent washing station 4 of any two.Meanwhile corresponding each washing station 4 is correspondingly arranged accordingly clearly
Wash needle 22.In this way, multiple washing stations 4 can work at the same time, cleaning efficiency is improved.
In the present embodiment, absorption station 5 is arranged close to the first washing station 41 in advance, and pre- absorption station 5 correspondence is set
It is equipped with magnet mounting base 31 and magnet 32 (pre- adsorption magnet).
In the present embodiment, the spacing between absorption station 5 and the first washing station 41 is adjacent equal to any two in advance
Reaction cup 6 between spacing.In this way, when one of reaction cup 6 is in the first washing station 41 and is cleaned, it is adjacent
Reaction cup 6 to be cleaned be located at pre- absorption station 5, it is pre- adsorb the corresponding magnet 32 of station 5 in advance will be in the reaction cup 6
Magnetic bead adsorbs in place, and reaction cup 6 is avoided just to start to adsorb when being in the first washing station 41, and then saves adsorption time, improves
Cleaning efficiency.
In the present embodiment, the absorption corresponding magnet 32 of station 5 is magnet 32 corresponding with the first washing station 41 in advance
In reaction cup 6 transport path it is ipsilateral.That is, the absorption corresponding magnet 32 of station 5 is also disposed on the first installation chamber 311 in advance
In.
In the present embodiment, the structure phase of station 5 and the corresponding magnet mounting base 31 of each washing station 4 is adsorbed in advance
Together.In this way, the structure of magnet mounting base 31 is general, replacement convenient for safeguarding.
In the present embodiment, magnet 32 is permanent magnet, for example, ndfeb magnet, samarium cobalt magnet, alnico magnet etc..
The course of work of magnetic bead cleaning device according to the present invention is briefly described below.
When cleaning reaction cup 6, reaction cup 6 is first moved to the first washing station 41, at this point, the magnetic bead in reaction cup 6 is
Through the side wall of cup for being adsorbed in reaction cup 6 under the action of magnet 32 that absorption station 5 is correspondingly arranged in advance.At this moment, using cleaning
Aspirating needle in needle 22 comprising all liq including liquid sample and unreacted reagent by taking out in reaction cup 6, so
Cleaning solution is injected into reaction cup 6 by the injection needle in cleaning needle 22 afterwards, the compound to magnetic bead as solid phase carrier carries out
Cleaning.
Then, reaction cup 6 is moved to the second washing station 42, at this point, the magnetic bead in reaction cup 6 is in corresponding second cleaning
Under the action of the magnet 32 that station 42 is arranged, the other side cup opposite with the side wall of cup is moved to from the side wall of cup of reaction cup 6
Wall, in moving process, magnetic bead group can be broken up, and the magnetic bead being wrapped in magnetic bead group is cleaned.
After the completion of magnetic bead absorption, cleaning solution is taken out using aspirating needle, reuses injection needle and refills cleaning solution.
Followed by reaction cup 6 is successively moved to third washing station 43 and the 4th washing station 44, repeats above-mentioned pumping
Liquid and injection process, until magnetic bead cleaning is finished.
By using above-mentioned technical proposal, magnetic bead cleaning device according to the present invention is had the advantage that
(1) in magnetic bead cleaning device of the invention, by the way that at least two washing stations are arranged, by each scavenger of correspondence
The magnet of position setting is alternately distributed in the two sides of reaction cup transport path, and when so that reaction cup converting washing station, magnetic bead can be
The wall surface opposite with the wall surface, during the motion, magnetic bead are moved to from a wall surface of reaction cup under the magneticaction of magnet
Group can be broken up cleaning, and then can adequately be cleaned to magnetic bead.
(2) in magnetic bead cleaning device of the invention, magnetic bead is adsorbed in advance by the way that pre- adsorption magnet is arranged, Neng Goujie
Adsorption time is saved, cleaning efficiency is improved.
(3) (that is, any by the spacing of the reaction cup that keeps any two adjacent in magnetic bead cleaning device of the invention
The spacing of two adjacent receiving portions) it is equal to the spacing of the adjacent washing station of any two, multiple reactions can be cleaned simultaneously
Cup improves cleaning efficiency.
(4) in magnetic bead cleaning device of the invention, when the corresponding magnet of two neighboring washing station acts on magnetic bead, magnetic
Pearl relative to reaction cup moving direction on the contrary, magnetic bead group can preferably be broken up.More fully clean magnetic bead.
(5) in magnetic bead cleaning device of the invention, each magnet installation holder structure is identical, and versatility is good, easy to maintain
Replacement.
(6) in magnetic bead cleaning device of the invention, using permanent magnet as magnet, relative to electromagnet, cost is relatively low,
It is high to control simple and reliable property.
Above specific embodiment elaborates technical solution of the present invention, but also needs to add explanation
:
(1) although illustrating delivery chute in the above-described embodiment in circular ring shape, but the invention is not restricted to this, delivery chute
It may be linear or other curve shapes.
(2) although illustrating that fixed part is integrally annular in shape in the above-described embodiment, but the invention is not restricted to this, Gu
Determining portion may be polygon, linear or other shapes.
(3) although illustrating that magnet mounting base includes two installation chambers in the above-described embodiment, each magnet installation
The structure of seat is identical, and but the invention is not restricted to this, and magnet mounting base can also only include an installation chamber, each magnet peace
The structure of dress seat can also be different.
(4) although being illustrated there are four washing stations in the above-described embodiment, but the invention is not restricted to this, scavenger
Position may be two, three, five, six or more.
(5) although illustrating that magnet is permanent magnet in the above-described embodiment, but the invention is not restricted to this, and magnet can also
To use electromagnet.
In addition, the present invention also provides a kind of Full-automatic chemiluminescence immunoassay analysis meters comprising above-mentioned magnetic bead cleaning
Device.
It is appreciated that the Full-automatic chemiluminescence immunoassay analysis meter for having the magnetic bead cleaning device has same beneficial effect
Fruit.
Claims (10)
1. a kind of magnetic bead cleaning device, which is characterized in that the magnetic bead cleaning device includes reaction cup conveying assembly, cleaning needle group
Part, magnet assemblies and at least two washing stations,
The reaction cup conveying assembly is for conveying reaction cup, so that the reaction cup is moved between the different washing stations
It is dynamic,
The cleaning needle assemblies are used to inject cleaning solution into the reaction cup and draw cleaning solution from the reaction cup,
The magnet assemblies include the magnet corresponding to each washing station setting, and the magnet can be by the reaction cup
In the magnetic bead be adsorbed in the wall of cup of the reaction cup, and
In any two adjacent washing stations, the magnet corresponding to one of them described washing station is located at institute
The side of the transport path of reaction cup is stated, the magnet corresponding to another described washing station is located at the defeated of the reaction cup
Send the other side in path.
2. magnetic bead cleaning device according to claim 1, which is characterized in that the corresponding institute of the two neighboring washing station
When stating magnet and acting on the magnetic bead, the magnetic bead is opposite relative to the moving direction of the reaction cup.
3. magnetic bead cleaning device according to claim 1, which is characterized in that the magnetic bead cleaning device further includes pre- absorption
Station,
The magnet assemblies include the pre- adsorption magnet corresponding to the pre- absorption station setting, and the pre- adsorption magnet can incite somebody to action
The magnetic bead in the reaction cup of the pre- absorption station is adsorbed in the wall of cup of the reaction cup,
The pre- adsorption magnet magnet corresponding with first washing station is located at the same of the transport path of the reaction cup
Side.
4. magnetic bead cleaning device according to claim 3, which is characterized in that the magnet assemblies include magnet mounting base,
Each washing station and the pre- absorption station are provided with the magnet mounting base,
The magnet mounting base includes the installation chamber of the two sides of the transport path positioned at the reaction cup, and the magnet is installed on
One of them described installation chamber.
5. magnetic bead cleaning device according to claim 3, which is characterized in that the reaction cup conveying assembly includes fixed part
And moving portion,
The fixed part is formed with the delivery chute mobile for the reaction cup,
The moving portion is provided with the receiving portion for accommodating the reaction cup, and the moving portion can exist with the reaction cup
It is moved in the delivery chute.
6. magnetic bead cleaning device according to claim 5, which is characterized in that the delivery chute is in circular ring shape.
7. magnetic bead cleaning device according to claim 5, which is characterized in that there is multiple, any two phase in described accommodation section
Spacing between adjacent described accommodation section is equal with the spacing between the adjacent washing station of any two, and with it is described
Spacing between first washing station and the pre- absorption station is equal.
8. magnetic bead cleaning device according to any one of claim 1 to 7, which is characterized in that the magnet is permanent magnet.
9. magnetic bead cleaning device according to any one of claim 1 to 7, which is characterized in that the number of the washing station
Amount is three to six.
10. a kind of Full-automatic chemiluminescence immunoassay analysis meter, which is characterized in that the Full-automatic chemiluminescence immunoassay analysis meter packet
Include magnetic bead cleaning device described in any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811611882.XA CN109433686A (en) | 2018-12-27 | 2018-12-27 | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811611882.XA CN109433686A (en) | 2018-12-27 | 2018-12-27 | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109433686A true CN109433686A (en) | 2019-03-08 |
Family
ID=65538603
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811611882.XA Pending CN109433686A (en) | 2018-12-27 | 2018-12-27 | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110586557A (en) * | 2019-09-11 | 2019-12-20 | 苏州长光华医生物医学工程有限公司 | Cleaning and separating device |
| WO2020192091A1 (en) * | 2019-03-27 | 2020-10-01 | 苏州长光华医生物医学工程有限公司 | Magnetic cleaning and separating device of immunity analyzer |
| CN112881725A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Sample detection equipment and magnetic cleaning and separating device and control method thereof |
| CN113504380A (en) * | 2021-06-15 | 2021-10-15 | 复星诊断科技(上海)有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
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