CN109115752A - A kind of interferon release automatic checkout system - Google Patents
A kind of interferon release automatic checkout system Download PDFInfo
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- CN109115752A CN109115752A CN201810975541.4A CN201810975541A CN109115752A CN 109115752 A CN109115752 A CN 109115752A CN 201810975541 A CN201810975541 A CN 201810975541A CN 109115752 A CN109115752 A CN 109115752A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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Abstract
The present invention relates to a kind of interferons to discharge automatic checkout system, including Sample pretreatment part and rear chemiluminescence detection part, Sample pretreatment part includes TIP head rest area, constant-temperature incubation tank module, reaction cup rest area and the XYZ three-dimensional motion mechanism that whole blood sample pipe rest area, liquid relief is arranged, and rear chemiluminescence detection part includes round reaction tray, the antibody liquid liquid adding arm being arranged in around reaction tray, magnetic bead liquid sample arm, cleaning component, stirring the upper arm member, handgrip the upper arm member, darkroom component.Compared with prior art, the present invention does not use centrifuge to carry out blood sample supernatant layering, it is only designed and is realized by the constant-temperature incubation case stratification after mixing, substantially reduce detection time, the accuracy of full-automatic testing result also improves significantly, integrated design is easy to operate, is suitable for industrialized production and uses, there is biggish application value.
Description
Technical field
The present invention relates to medical instruments fields, discharge automatic checkout system more particularly, to a kind of interferon.
Background technique
Home and abroad is used to detect the instrument of the gamma interferon of tuberculosis infection T cell release, sample pre-processing at present
Mostly use the whole blood sample pipe of acquisition, by adding negative culture solution N, working solution T, positive cultures P reagent, incubator into
Row is incubated for for a long time to stimulate the T lymphocyte for infecting tuberculosis, it is made to generate release interferon.Incubation tube is placed on later
High speed centrifugation is carried out on centrifuge, isolates the supernatant of interferon that T lymphocyte is stimulated and generates, supernatant is determined
It measures out.Post-processing operation is carried out by enzyme linked immunosorbent assay or chemoluminescence method.Enzyme linked immunosorbent assay and chemoluminescence method
It is to judge body whether by mycobacterium tuberculosis infection according to the concentration of the gamma interferon of tubercle bacillus specific T lymphocyte generation.
And enzyme-linked immunospot assay then by gamma interferon formed spot-analysis tubercle bacillus specific T lymphocyte number come
Judge whether patient infects tubercle bacillus.It is all a kind of quantitative measuring method that interferon release detects automatically, but centre is not
It can avoid having artificial Attended Operation, test result fluctuation often led to greatly on the subjective human factor that experimental result influences, because
This considers the detecting instrument for improving tuberculosis infection T cell release gamma interferon, realizes its whole operation process full-automatic
Change, the reduction human factor of maximum possible.
Summary of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide a kind of interferons to discharge
Automatic checkout system.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of interferon release automatic checkout system, including Sample pretreatment part and rear chemiluminescence detection part,
The Sample pretreatment part includes setting whole blood sample pipe rest area, the TIP head rest area of liquid relief, constant-temperature incubation
Tank module, reaction cup rest area and XYZ three-dimensional motion mechanism,
It is described after chemiluminescence detection part include round reaction tray, the antibody liquid liquid adding arm being arranged in around reaction tray,
Magnetic bead liquid sample arm, cleaning component, stirring the upper arm member, handgrip the upper arm member, darkroom component.
The constant-temperature incubation tank module is two mutually independent constant-temperature incubation casees, is located at whole blood sample pipe rest area, moves
The centre in the surrounded region in the head rest area TIP and reaction cup rest area of liquid,
The upper cover of constant-temperature incubation case can switch gate horizontal movement, the constant temperature that upper cover and bottom can be carried out temperature setting adds
Heat can be heated using silicon rubber heating sheet, 96 hole deep-well plates are placed in case.
The XYZ three-dimensional motion mechanism by side-to-side movement large arm, move forward and backward large arm, up and down motion liquid relief module and up and down
A glass module composition is grabbed in movement, and the side-to-side movement large arm and the large arm that moves forward and backward are mutually perpendicular to, and is located at Sample pretreatment portion
The top divided, the up and down motion liquid relief module and the up and down motion are grabbed glass module and are transported in side-to-side movement large arm and/or front and back
Sliding rail sliding in dynamic large arm.Up and down motion liquid relief module can be equipped with the Cavro air driven pump of Tecan company, corresponding to insert
Tip head move the reagent or sample liquid of 20uL~1000uL respectively, glass module is grabbed in up and down motion can install Japanese SMC company
LECP series simple type electricity grab to grab reaction cup.
4 sample tube framves for respectively having 16 holes are placed in whole blood sample pipe rest area, have whole blood before the sample tube frame
Sample places indicator light, and red and green color instruction designs realization, sample tube frame using GQ12T-D/32/RG/DC24V/S model
It is provided with plug-in type whole blood sample frame below and places sensor, is realized using SS-5GL microswitch.
It is the TIP head cartridge in 96 holes that the rest area TIP, which places 4 respectively, and it is respectively 60 that the reaction cup rest area, which places 4,
The reaction cup box in hole.
The reaction tray is the disk with 120 reaction cup positions, and bottom passes through rack gear disk and stepper motor close fit
Design, and initial bit home sensor is installed back, it walks and is designed using grid tooth.
Reaction tray is walked can be added antibody reagent liquid immediately below 8 hole locations to antibody liquid liquid adding arm at any time, and antibody liquid reagent is put
It sets area to place for refrigeration reagent, settable 2~10 DEG C of storing reagents, refrigeration modes utilize the Peltier effect of semiconductor material
It realizes, the cold heat dissipation of oil.Antibody liquid liquid adding arm differs 60 reaction cup positions with magnetic bead liquid sample arm, magnetic bead liquid reagent rest area,
Substrate solution reagent rest area and antibody liquid reagent rest area are all made of semiconductor material Peltier effect to carry out refrigeration design.
The magnet steel component installed on reaction tray pedestal immediately below cleaning component uses symmetrical double Magnet designs, totally 10 couples of 5mm x
The magnet installation position of 5mm x 10mm is used for installation magnet, is equipped with 3 crosspointers, a waste suction on cleaning arm component-mounted boards
The single-needle design of the single needle of liquid, one plus substrate solution, mixing arm are installed close to cleaning arm, and stirring hole location is close to adding substrate solution hole location
Design, be equally equipped in handgrip the upper arm member Japanese SMC company LECP series simple type electricity grab realize crawl reaction cup into
Darkroom reading and abandoning reaction cup design are realized, the H10682 photoelectricity of Japanese shore pine (HAMAMATSU) company is housed in the component of darkroom
Multiplier tube carries out photon counting.
The present invention combines the preprocessing system of whole blood sample and chemiluminescence detection system after disc type are orderly, in
Between centrifugal treating is not carried out using centrifuge, but use and be incubated for stratification technology, it is pioneering at home and abroad to belong to technology.γ
The automatic detection system machine of interferon detection will greatly improve what tuberculosis infection T cell in blood sample detected
It is true and reliable.Two independent constant-temperature incubation case designs can make integrated instrument work more flexible, can be put into patient stage by stage
Blood sample is detected, and can also make constant-temperature incubation draw box mechanism installing and dismounting more convenient, is provided convenience for maintenance.Structure of the invention
Novelty, instrumentation is more scientific rationally, easy to use, easy to operate, is suitable for industrialized production and uses, there is biggish application
Value.
The present invention uses integrated design, and maximum does 64 person-portion whole blood samples, is put into instrument collecting patient whole blood's sample
Deep-well plates are all added to automation equipment after on device, are completed in 2 hours.It is small that the setting time 18~22 is incubated in constant-temperature incubation case
When, it is realized in 24 hours from whole blood is begun placing into result out.It needs 3 days or so that knot could be gone out relative to traditional test mode
Fruit, will substantially reduce detection time, and the accuracy of full-automatic testing result also significantly improves.
General traditional detection mode is after collecting patient whole blood's sample, and points three parts are dispensed into test tube, respectively plus
Enter negative culture solution N, working solution T and positive cultures P reagent, after carrying out manual mixing, is put into 37 DEG C of constant-temperature incubation casees, carries out
It is incubated for for a long time to stimulate the T lymphocyte for infecting tuberculosis, it is made to generate release interferon.After incubation time arrives, take out
Each incubation tube is placed on 3000 turns of 10 minutes high speed centrifugations of progress on centrifuge, isolates the supernatant containing interferon.By hand
Work acquires quantitative supernatant as test sample, carries out post-processing operation by enzyme linked immunosorbent assay or chemoluminescence method.Enzyme
Connection immunoabsorption and chemoluminescence method are that the concentration of the gamma interferon generated according to tubercle bacillus specific T lymphocyte is sentenced
Whether off line body is by mycobacterium tuberculosis infection.Its concentration-response is exactly T cell concentration level in blood sample by mycobacterium tuberculosis infection
Relative value.It is a kind of detection infection common detection method lungy, but since intermediate artificial link hand-manipulated is more, it is right
It is big that the factor that experimental result influences often leads to test result fluctuation, therefore considers complete machine integrated design, operating process it is complete
The Automation Design can significantly improve the accuracy detected by the T cell of mycobacterium tuberculosis infection.Instrument had carried out actual test,
As a result stability and reliability, which truly has, to be significantly improved, and maximum possible reduces human factor.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is overlooking structure diagram of the invention；
Fig. 3 is the structural schematic diagram of Sample pretreatment part；
Fig. 4 is the structural schematic diagram of rear chemiluminescence detection part.
In figure, 1- side-to-side movement large arm, 2- move forward and backward large arm, 3- up and down motion liquid relief module, 4- up and down motion grab cup
Module, 5- whole blood sample pipe rest area, 6- whole blood sample places indicator light, 7- whole blood sample frame places sensor, 8- first is permanent
Warm incubator, the second constant-temperature incubation of 9- case, 10-TIP rest areas, 11- reaction cup rest area, 12- reaction tray, 13- antibody liquid
Liquid adding arm, 14- antibody liquid reagent rest area, 15- magnetic bead liquid sample arm, 16- magnetic bead liquid reagent rest area, 17- substrate solution reagent
Rest area, 18- cleaning component, 19- stirring the upper arm member, 20- handgrip the upper arm member, the darkroom 21- component, 22- reagent solution refrigeration are placed
Area, 23- magnet steel component.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection scope.
Embodiment
A kind of interferon discharges automatic checkout system, and structure is as shown in Figs. 1-2, including Sample pretreatment part and after
Chemiluminescence detection part, it is as shown in Figures 3 and 4 respectively.Sample pretreatment part include setting whole blood sample pipe rest area 5,
TIP head rest area 10, constant-temperature incubation tank module, reaction cup rest area 11 and the XYZ three-dimensional motion mechanism of liquid relief, rear chemiluminescence
Detection part include circular reaction tray 12, the antibody liquid liquid adding arm 13 being arranged in around reaction tray 12, magnetic bead liquid sample arm 15,
Clean component 18, stirring the upper arm member 19, handgrip the upper arm member 20, darkroom component 21.
Constant-temperature incubation tank module is two mutually independent constant-temperature incubation casees, including the first constant-temperature incubation case 8 and second
Constant-temperature incubation case 9, in whole blood sample pipe rest area 5, the surrounded region in TIP rest areas 10 and reaction cup rest area 11
Between, the upper cover of constant-temperature incubation case can switch gate horizontal movement, upper cover and bottom can be carried out the heated at constant temperature of temperature setting, can be with
It is heated using silicon rubber heating sheet, 96 hole deep-well plates is placed in case.
XYZ three-dimensional motion mechanism by side-to-side movement large arm 1, move forward and backward large arm 2, up and down motion liquid relief module 3 and up and down
The composition of glass module 4 is grabbed in movement, side-to-side movement large arm 1 and is moved forward and backward large arm and is mutually perpendicular to 2, positioned at the upper of Sample pretreatment part
Side, is provided with sliding rail.Up and down motion liquid relief module 3 and up and down motion grab glass module 4 in side-to-side movement large arm 1 and/or front and back
Move the sliding rail sliding in large arm 2.Up and down motion liquid relief module 3 can be equipped with the Cavro air driven pump of Tecan company, to insert
The corresponding Tip reagents for moving 20uL~1000uL respectively or sample liquid, glass module 4 is grabbed in up and down motion can install Japan
The LECP series simple type electricity of SMC company is grabbed to grab reaction cup.
4 sample tube framves for respectively having 16 holes are placed in whole blood sample pipe rest area 5, have whole blood sample before the sample tube frame
Indicator light 6 is placed, red and green color indicates to design realization using GQ12T-D/32/RG/DC24V/S model, after sample tube frame
Face is provided with plug-in type whole blood sample frame and places sensor 7, is realized using SS-5GL microswitch.It puts TIP rest areas 10
Setting 4 respectively is the TIP head cartridge in 96 holes, and it is the reaction cup box in 60 holes that reaction cup rest area 11, which places 4 respectively,.
Reaction tray 12 is the disk with 120 reaction cup positions, and bottom is set by rack gear disk and stepper motor close fit
Meter, and initial bit home sensor is installed back, it walks and is designed using grid tooth.
Reaction tray 12 is walked can be added antibody reagent liquid at any time immediately below 8 hole locations to antibody liquid liquid adding arm 13, antibody liquid examination
Agent rest area 14 is that refrigeration reagent is placed, and settable 2~10 DEG C of storing reagents, refrigeration modes utilize semiconductor material
Peltier effect realizes, the cold heat dissipation of oil.Antibody liquid liquid adding arm 13 differs 60 reaction cup positions, magnetic with magnetic bead liquid sample arm 15
Pearl liquid reagent rest area 16, substrate solution reagent rest area 17 and antibody liquid reagent rest area 14 are all made of semiconductor material
Peltier effect carries out refrigeration design.The magnet steel component 23 installed on reaction tray pedestal immediately below cleaning component 18 uses
Symmetrical double Magnet designs, the magnet installation position of totally 10 couples of 5mm x 5mm x 10mm is used for installation magnet, cleans the upper arm member
The single needle of 3 crosspointers, the single needle of waste suction liquid, one plus substrate solution is installed, mixing arm 19 is close to cleaning on mounting plate 18
Arm installation, stirring hole location are equally equipped with the LECP of Japanese SMC company close to adding substrate solution hole location to design in handgrip the upper arm member 20
Series simple type electricity grabs to realize that crawl reaction cup is read into darkroom and abandoning reaction cup design is realized, day is housed in darkroom component 21
The H10682 photomultiplier tube of this shore pine (HAMAMATSU) company carries out photon counting.
Deep-well plates band carries reaction solution and crosses incubation stratification in incubator back warp, after incubation time arrives, incubator upper cover plate
It will open, XYZ three-dimensional motion mechanism moves to the top of the first constant-temperature incubation case 8 or the second constant-temperature incubation case 9, and downlink is beaten in place
Open handgrip, crawl deep-well plates are incubated for upper cover, again in the case where incubator upper cover plate is closed, put deep-well plates and are incubated for upper cover to incubating
It educates on box cover plate.Incubator upper cover plate is opened, XYZ three-dimensional motion mechanism moves to TIP rest areas 10, takes corresponding TIP
Head arrives in corresponding constant-temperature incubation case deep-well plates, draws quantitative supernatant, is added to the phase for putting the reaction tray 12 of reaction cup well in advance
Answer hole location.Reaction tray 12 is moved by working sequence, the next to antibody liquid liquid adding arm 13, and reagent needle will add antibody liquid to respective reaction
Isothermal reaction is carried out in cup；When reaction cup moves to, magnetic bead liquid liquid adding arm 15 is the next, and reagent needle will add magnetic bead liquid to respective reaction
Isothermal reaction is carried out in cup, when then, reaction cup is just moved into the magnet steel portion of cleaning component 18 with the magnetic bead liquid reaction time
Part 23, when permanent magnet absorption magnetic bead particles arrive reaction cup side, cleaning needle goes downwards to bottom of a cup, and it is remaining to sop up reaction solution, clear
When washing needle lift motion to rim of a cup position, cleaning needle will sequentially be squeezed into quantitative cleaning solution to reaction cup, after such three circulations,
Downlink is sopped up into reaction solution remnants in the 4th cleaning pin position needle.In next reaction cup position, substrate solution is added in substrate needle
After being mixed well, reaction solution starts to fluoresce, and grabs reaction cup to darkroom in the set time, carries out darkroom photon counting,
The size of photon value is directly proportional to interferon concentration in supernatant.According to the amount that interferon discharges, patient's quilt can be reflected
Mycobacterium tuberculosis infection T lymphocyte number, clinic is usually used in auxiliary diagnosis lungy.
When patient whole blood's blood sample is sent to inspection center and goes to clinical trial, sample tube is subjected to hand-held bar code scan first
Device carries out bar code scan, and sample tube position is inserted into after scanning, and software chooses insertion position information and will be associated with patient's typing information,
After sample rack insertion, the display lamp of sample rack push-in in place is installed on deck plate and is shown.
Sample rack placement sensor is installed on platen and detects that sample rack has been pushed into place, refers to simultaneous display before panel
Show lamp.Instrument, which starts lower sample by application software, to be tested, and the XYZ three-dimensional motion mechanism of pre-treatment is firstly moved to TIP placements
Area 10, plug it is TIP corresponding after, move to reagent solution refrigeration rest area 22, the negative culture solution of corresponding quantitative absorptions works
Liquid, positive cultures, to 9 position of the first constant-temperature incubation case 8 or the second constant-temperature incubation case deep hole be incubated for plate corresponding position, according to
After secondary plus good quantitative negative culture solution, working solution, positive cultures, pre-treatment XYZ three-dimensional motion mechanism is re-moved to TIP
Head place 10th area, plug it is TIP corresponding after, move to corresponding whole blood sample pipe rest area 5, draw quantitative whole blood
This, the deep hole for being moved to 9 position of the first constant-temperature incubation case 8 or the second constant-temperature incubation case is incubated for plate corresponding position, and it is fixed to sequentially add
The whole blood sample of amount.After deep hole is incubated for the corresponding detection blood sample of plate addition, XYZ three-dimensional motion mechanism presses working sequence, is plugged
TIP are arrived corresponding hole site, are needed to carry out blood sample and are walked with the mixing operation of corresponding negative culture solution, working solution or positive cultures
It plays, XYZ three-dimensional motion mechanism presses working sequence, it needs to abandon the TIP TIP heads more renewed in time to mix different blood samples,
After each hole cmpletely mix.Having abandoned TIP XYZ three-dimensional motion mechanisms will be moved to the first constant-temperature incubation case 8
Or 9 top of the second constant-temperature incubation case, downlink grab corresponding deep hole and are incubated for lid, maneuvering board cooperation opens the door, closes the door on insulating box
On the basis of, deep hole is incubated for lid and is placed on deep hole incubator, lid is covered and carries out stationary incubation, incubation time is set as 18
Between~22 hours, suitable definite value is chosen according to effect is incubated for, incubation time, which can according to need, herein is adjusted.Deep hole
Strip carries reaction solution and carries out stratification incubation in incubator, is that our full-automatic interferons discharge automatic checkout system one
The core and important component of body machine patent of invention belong to pioneering both at home and abroad.By actual measurement, stablize feasible.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring substantive content of the invention.
Claims (10)
1. a kind of interferon discharges automatic checkout system, which is characterized in that the detection system include Sample pretreatment part and
Chemiluminescence detection part afterwards,
The Sample pretreatment part includes setting whole blood sample pipe rest area, the TIP head rest area of liquid relief, constant-temperature incubation case mould
Block, reaction cup rest area and XYZ three-dimensional motion mechanism,
Chemiluminescence detection part includes round reaction tray, the antibody liquid liquid adding arm, the magnetic bead that are arranged in around reaction tray after described
Liquid sample arm, cleaning component, stirring the upper arm member, handgrip the upper arm member, darkroom component.
2. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the constant-temperature incubation
Tank module is two mutually independent constant-temperature incubation casees, positioned at whole blood sample pipe rest area, the head rest area TIP of liquid relief and reaction
The centre in cup the surrounded region in rest area,
The upper cover of constant-temperature incubation case can switch gate horizontal movement, upper cover and bottom can be carried out the heated at constant temperature of temperature setting, case
96 hole deep-well plates of interior placement.
3. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the XYZ is three-dimensional
Movement mechanism by side-to-side movement large arm, move forward and backward large arm, up and down motion liquid relief module and move up and down and grab a glass module and form, institute
It states side-to-side movement large arm and the large arm that moves forward and backward is mutually perpendicular to, positioned at the top of Sample pretreatment part, the fortune up and down
Dynamic liquid relief module and the up and down motion grab glass module in side-to-side movement large arm and/or move forward and backward sliding rail sliding in large arm.
4. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the whole blood sample
4 sample tube framves for respectively having 16 holes are placed in pipe rest area, have whole blood sample to place before the sample tube frame and set behind indicator light
It is equipped with plug-in type whole blood sample frame and places sensor.
5. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that described TIP puts
Setting area and placing 4 respectively is the TIP head cartridge in 96 holes, and it is the reaction cup box in 60 holes that the reaction cup rest area, which places 4 respectively,.
6. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the reaction tray is
Disk with 120 reaction cup positions, bottom is designed by rack gear disk and stepper motor close fit, and is equipped with back initial bit
Home sensor.
7. a kind of interferon according to claim 6 discharges automatic checkout system, which is characterized in that the antibody liquid adds
Liquid arm differs 60 reaction cup positions with magnetic bead liquid sample arm.
8. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the cleaning component
Lower part is equipped with magnetic steel component, and using symmetrical double magnet arrangements, 10 pairs of magnet installation position is arranged altogether.
9. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the stirring arm
The single needle of 3 crosspointers, a waste suction liquid single needle and one plus substrate solution is installed on part.
10. a kind of interferon according to claim 1 discharges automatic checkout system, which is characterized in that the darkroom portion
Photomultiplier tube is installed in part.
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| CN201810975541.4A CN109115752A (en) | 2018-08-24 | 2018-08-24 | A kind of interferon release automatic checkout system |
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| CN110108540A (en) * | 2019-05-15 | 2019-08-09 | 江西业力医疗器械有限公司 | Sample processing system and method |
| CN110488031A (en) * | 2019-09-06 | 2019-11-22 | 浙江盛域医疗技术有限公司 | A kind of full-automatic thrombelastogram instrument and its tip mechanism |
| CN113188874A (en) * | 2021-06-05 | 2021-07-30 | 长沙迈迪克智能科技有限公司 | Full-automatic fluorescent dyeing instrument |
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| CN113188874A (en) * | 2021-06-05 | 2021-07-30 | 长沙迈迪克智能科技有限公司 | Full-automatic fluorescent dyeing instrument |
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Application publication date: 20190101 |