CN103267867A - Fully-automatic chemiluminescent immunoassay analyzer - Google Patents
Fully-automatic chemiluminescent immunoassay analyzer Download PDFInfo
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- CN103267867A CN103267867A CN201310167162XA CN201310167162A CN103267867A CN 103267867 A CN103267867 A CN 103267867A CN 201310167162X A CN201310167162X A CN 201310167162XA CN 201310167162 A CN201310167162 A CN 201310167162A CN 103267867 A CN103267867 A CN 103267867A
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Abstract
The invention relates to a fully-automatic chemiluminescent immunoassay analyzer. The fully-automatic chemiluminescent immunoassay analyzer comprises a frame and a control system, a sample zone, a lath feeding system, an incubation zone and a lath detecting system are sequentially arranged on the frame from the left to the right, a fluid path system is arranged below or at the right side of the incubation zone, a reagent zone is arranged below the incubation zone and below or at the right side of the lath detecting system, a sample arm is arranged at the left side of the frame, a reagent arm is arranged at the right side of the frame, a first push rod arm is arranged above the lath feeding system on the frame, a second push rod arm is arranged in the incubation zone, and the lath feeding system, the incubation zone, the lath detecting system, the fluid path system, the sample arm, the reagent arm, the first push rod arm and the second push rod arm are respectively electrically connected with the control system. The fully-automatic chemiluminescent immunoassay analyzer has the advantages of simple structure, convenient operation, high automation degree, and supporting of the non-shutdown loading.
Description
Technical field
The present invention relates to a kind of full-automatic chemical luminescence immunoassay instrument.
Background technology
Thereby chemical illumination immunity analysis instrument is by detecting patient's serum carries out immunoassay to human body medical test instrument.Quantitative patients serum and horseradish peroxidase (HRP) are joined solid-phase coating to be had in the White-opalescent microwell plate of antibody, the antibody specificity of testing molecule in the serum on the bond of horseradish peroxidase and solid phase carrier is combined, the unreacted free composition of separating, washing, then, add liquid of the luminous end, the free energy that utilizes chemical reaction to discharge excites intermediate, gets back to excited state from ground state, and energy discharges with the form of photon.But, existing full-automatic chemical luminescence immunoassay instrument all is be used to reading the faint light energy that 96 or 48 hole microwell plates send in the market, be used for measuring the concentration of patients serum's certain antibody of sample or antigen, so-called 96 or 48 hole microwell plates are to comprise 96 or 48 reaction cup on the plank, patients serum's sample that each need detect is placed in the reaction cup, the sample size that detects when needs has only several or needs to use a monoblock 96 or 48 hole microwell plates equally tens the time, therefore causes a large amount of wastes; On the other hand, present existing full-automatic chemical luminescence immunoassay instrument generally once can only detect a microwell plate, and second microwell plate need be put into detector again and detect after first detection finished, therefore, the speed that detects is unhappy, and staff's detection efficiency is not high; 96 or 48 microwell plate is longer in the required time of first hole of application of sample to last hole, and therefore the consistance to the result has certain influence; The structure of microwell plate can't solve the problem of hole interdigit light cross pollution fully.
Summary of the invention
The invention provides a kind of simple in structure, easy to operate, automaticity is high, support not shut down a kind of full-automatic chemical luminescence immunoassay instrument of loading.
The present invention is achieved through the following technical solutions:
A kind of full-automatic chemical luminescence immunoassay instrument, comprise support body and control system, be provided with sample area on the described support body from left to right successively, the lath feed system, incubation district and lath detection system, below or the right side in described incubation district are provided with liquid-way system, the below in described incubation district, below or the right side of described lath detection system are provided with reagent area, described support body left side is provided with sample arm, the right side is provided with the reagent arm, be positioned at described lath feed system top on the described support body and be provided with first pusher arms, be positioned at inside, described incubation district and be provided with second pusher arms, described lath feed system, the incubation district, the lath detection system, liquid-way system, sample arm, the reagent arm, first pusher arms and second pusher arms are electrically connected with described control system respectively.
Described lath feed system comprises the lath frame, advances panel assembly, plate taking device and application of sample snubber assembly, describedly advance panel assembly, plate taking device and application of sample snubber assembly and all be fixed on the described support body, described plate taking device is located at the described panel assembly rear of advancing, described application of sample snubber assembly is located between described plate taking device and the described incubation district, describedly advances panel assembly, plate taking device and application of sample snubber assembly and is electrically connected with described control system respectively; Describedly advance panel assembly and comprise shell, storehouse door, first motor and first slide mechanism, put into the bottom of described shell after the user is placed on lath on the described lath frame from the storehouse door, under the drive of first motor, by first slide mechanism lath frame is lifted to the top of shell; Described plate taking device comprises handgrip, second motor and second slide mechanism, and described handgrip takes out the lath frame under the drive of second motor and second slide mechanism in shell; Described application of sample snubber assembly comprises application of sample buffer zone base, the 3rd motor and the 3rd slide mechanism, lath on the described lath frame moves on the described application of sample buffer zone base by first pusher arms, moving linearly under the drive of the 3rd motor and the 3rd slide mechanism, and carry out application of sample by sample arm.
Described incubation district comprises lucifuge shell, incubation district base, the 4th motor, the 4th slide mechanism and second pusher arms, described incubation district base, the 4th slide mechanism and second pusher arms all are located at described lucifuge shell inside, lath behind the application of sample is moved on the incubation district base from application of sample buffer zone base, under the drive of the 4th motor and the 4th slide mechanism, shake, described second pusher arms is provided with sensitization liquid sample needle, described liquid-way system comprises sensitization liquid and cleaning fluid, is connected with described sensitization liquid phase by ram pump.
Described lath detection system comprises detection module, sliding block, lath driver module and lath active module, and described detection module is positioned at described lath active module top, and described sliding block slides and is located at described lath driver module top.
Described lath active module comprises lath chute, Qianmen and back door, described lath is located in the described lath chute, an end of described lath chute is located at described Qianmen by the Qianmen resetting-mechanism, the bottom of the described lath chute other end is provided with fluting, described fluting top is located at by the back door resetting-mechanism in described back door, described Qianmen is provided with jack, and described back door is provided with slot.
Described sliding block comprises fixed head, the lath fixation fork, direct current generator and leading screw, described lath fixation fork is slidingly connected by slide rail and described fixed head, described direct current generator is fixed on the fixed head, and be provided with driving gear at output terminal, described leading screw one end is connected with described lath fixation fork, the other end is provided with follower gear, described driving gear and follower gear are meshed, one side of described lath fixation fork is provided with the Qianmen inserted link, described Qianmen inserted link inserts in the jack at described Qianmen when needs drive the Qianmen, the lower surface of described lath fixation fork is provided with the back door inserted link, described back door inserted link inserts in the slot at described back door when needs drive the back door, described lath fixation fork is provided with some inserted sheets, and described lath chute wall is provided with groove, and described inserted sheet passes described groove and inserts between the gap on the described lath.
Described full-automatic chemical luminescence immunoassay instrument also comprises dilution vibration district, and described dilution vibration district is fixed on the described support body, and between described sample area and lath feed system.
Described lath frame lower surface is provided with two blocks, and fillet is fallen at the two ends of described block.
Be equipped with clamp clip on described application of sample buffer zone base and the incubation district base, described lath chute is provided with clamp clip, all fixes by screw.
Described support body outside is provided with housing.
The beneficial effect that the present invention brings is:
Among the present invention, loading is not shut down in the support of described full-automatic chemical luminescence immunoassay instrument, be that the user can will place the lath frame adding of lath from advancing panel assembly continuously under non-stop-machine situation, take out by plate taking device again, and at application of sample snubber assembly place application of sample, lath immigration incubation district carries out the incubation processing after the application of sample, lath after the lath of lath immigration afterwards detection system detects and will detect is discharged in the pail for used dressings, above whole process can be carried out under non-stop-machine state continuously, so just improve detection efficiency, and guaranteed the accuracy that detects; On the other hand, 96 or 48 hole microwell plates are resolved into single lath enter detection, more flexible than using 96 or 48 hole microwell plates to detect, and save cost; When single lath entered flowing water and detects, from first reaction cup application of sample or add reagent to last reaction cup application of sample or to add time interval of reagent short, and then testing result was more accurate; Inserted sheet on the described lath fixation fork passes described groove and inserts between the gap on the described lath, can reduce the hole interdigit light cross pollution of adjacent two reaction cup, and on the other hand, described inserted sheet can play the effect that lath moves that drives.
Description of drawings
Below in conjunction with accompanying drawing the present invention is described in further detail.
Fig. 1 is the structural representation of full-automatic chemical luminescence immunoassay instrument of the present invention.
Fig. 2 is the structural representation of lath feed system of the present invention.
Fig. 3 is the structural representation of lath frame of the present invention.
Fig. 4 is the structural representation in incubation of the present invention district.
Fig. 5 is the structural representation of lath detection system of the present invention.
Fig. 6 is the structural representation of lath active module of the present invention.
Fig. 7 is the structural representation of sliding block of the present invention.
Fig. 8 is the structural representation of lath fixation fork of the present invention.
The label of component names correspondence is as follows among the figure:
1, support body; 2, control system; 3, sample area; 4, lath feed system; 5, incubation district; 6, lath detection system; 7, reagent area; 8, sample arm; 9, reagent arm; 10, first pusher arms; 11, second pusher arms; 12, lath frame; 13, shell; 14, storehouse door; 15, first motor; 16, first slide mechanism; 17, lath; 18, handgrip; 19, second motor; 20, second slide mechanism; 21, application of sample buffer zone base; 22, the 3rd motor; 23, the 3rd slide mechanism; 24, incubation district base; 25, the 4th motor; 26, the 4th slide mechanism; 27, sensitization liquid sample needle; 28, sensitization liquid; 29, cleaning fluid; 30, ram pump; 31, detection module; 32, sliding block; 33, lath driver module; 34, lath active module; 35, lath chute; 36, Qianmen; 37, back door; 38, Qianmen resetting-mechanism; 39, fluting; 40, back door resetting-mechanism; 41, jack; 42, slot; 43, fixed head; 44, lath fixation fork; 45, direct current generator; 46, leading screw; 47, slide rail; 48, driving gear; 49, follower gear; 50, Qianmen inserted link; 51, back door inserted link; 52, inserted sheet; 53, groove; 54, dilution vibration district; 55, block; 56, clamp clip; 57, screw.
Embodiment
The present invention is described in further detail below in conjunction with drawings and Examples:
Embodiment as full-automatic chemical luminescence immunoassay instrument of the present invention, as shown in Figure 1, comprise support body 1 and control system 2, be provided with sample area 3 on the described support body 1 from left to right successively, lath feed system 4, incubation district 5 and lath detection system 6, the below in described incubation district 5 is provided with liquid-way system, the below in described incubation district 5 is provided with reagent area 7, described support body 1 left side is provided with sample arm 8, the right side is provided with reagent arm 9, be positioned at described lath feed system 4 tops on the described support body 1 and be provided with first pusher arms 10, be positioned at 5 inside, described incubation district and be provided with second pusher arms 11, described lath feed system 4, incubation district 5, lath detection system 6, liquid-way system, sample arm 8, reagent arm 9, first pusher arms 10 and second pusher arms 11 are electrically connected with described control system 2 respectively.
In the present embodiment, as shown in Figures 2 and 3, described lath feed system 4 comprises lath frame 12, advances panel assembly, plate taking device and application of sample snubber assembly, describedly advance panel assembly, plate taking device and application of sample snubber assembly and all be fixed on the described support body 1, described plate taking device is located at the described panel assembly rear of advancing, described application of sample snubber assembly is located between described plate taking device and the described incubation district 5, describedly advances panel assembly, plate taking device and application of sample snubber assembly and is electrically connected with described control system 2 respectively; Describedly advance panel assembly and comprise shell 13, storehouse door 14, first motor 15 and first slide mechanism 16, put into the bottom of described shell 13 after the user is placed on lath 17 on the described lath frame 12 from storehouse door 14, under the drive of first motor 15, by first slide mechanism 16 lath frame 12 is lifted to the top of shell 13; Described plate taking device comprises handgrip 18, second motor 19 and second slide mechanism 20, and described handgrip 18 takes out lath frame 12 under the drive of second motor 19 and second slide mechanism 20 in shell 13; Described application of sample snubber assembly comprises application of sample buffer zone base 21, the 3rd motor 22 and the 3rd slide mechanism 23, lath 17 on the described lath frame 12 moves on the described application of sample buffer zone base 21 by first pusher arms 10, moving linearly under the drive of the 3rd motor 22 and the 3rd slide mechanism 23, and carry out application of sample by sample arm 8.
In the present embodiment, as shown in Figure 4, described incubation district 5 comprises lucifuge shell (not shown), incubation district base 24, the 4th motor 25, the 4th slide mechanism 26 and second pusher arms 11, described incubation district base 24, the 4th slide mechanism 26 and second pusher arms 11 all are located at described lucifuge shell inside, lath 17 behind the application of sample is moved on the incubation district base 24 from application of sample buffer zone base 21, under the drive of the 4th motor 25 and the 4th slide mechanism 26, shake, described second pusher arms 11 is provided with sensitization liquid sample needle 27, described liquid-way system comprises sensitization liquid 28 and cleaning fluid 29, is connected with described sensitization liquid 28 by ram pump 30.
In the present embodiment, as shown in Figure 5, described lath detection system 6 comprises detection module 31, sliding block 32, lath driver module 33 and lath active module 34, described detection module 31 is positioned at described lath active module 34 tops, and described sliding block 32 slides and is located at described lath driver module 33 tops.
In the present embodiment, as shown in Figure 6, described lath active module 34 comprises lath chute 35, Qianmen 36 and back door 37, described lath 17 is located in the described lath chute 35, an end of described lath chute 35 is located at by Qianmen resetting-mechanism 38 in described Qianmen 36, and the bottom of described lath chute 35 other ends is provided with fluting 39, and described fluting 39 tops are located at by back door resetting-mechanism 40 in described back door 37, described Qianmen 36 is provided with jack 41, and described back door 37 is provided with slot 42.
In the present embodiment, as shown in Figure 7 and Figure 8, described sliding block 32 comprises fixed head 43, lath fixation fork 44, direct current generator 45 and leading screw 46, described lath fixation fork 44 is slidingly connected by slide rail 47 and described fixed head 43, described direct current generator 45 is fixed on the fixed head 43, and be provided with driving gear 48 at output terminal, described leading screw 46 1 ends are connected with described lath fixation fork 44, the other end is provided with follower gear 49, described driving gear 48 and follower gear 49 are meshed, one side of described lath fixation fork 44 is provided with Qianmen inserted link 50, described Qianmen inserted link 50 inserts in the jack 41 at described Qianmen 36 when needs drive Qianmen 36, the lower surface of described lath fixation fork 44 is provided with back door inserted link 51, described back door inserted link 51 inserts in the slot 42 at described back door 37 when needs drive back door 37, described lath fixation fork 44 is provided with seven inserted sheets 52, and described lath chute 35 sidewalls are provided with groove 53, and described inserted sheet 52 passes between the gap that described groove 53 inserts on the described lath 17.
In the present embodiment, described full-automatic chemical luminescence immunoassay instrument also comprises dilution vibration district 54, and described dilution vibration district 54 is fixed on the described support body 1, and between described sample area 3 and lath feed system 4.
In the present embodiment, described lath frame 12 lower surfaces are provided with two blocks 55, and fillet is fallen at the two ends of described block 55.
In the present embodiment, be equipped with clamp clip 56 on described application of sample buffer zone base 21 and the incubation district base 24, described lath chute 35 is provided with clamp clip 56, and is all fixing by screw 57.
In the present embodiment, described support body 1 outside is provided with the housing (not shown).
Claims (10)
1. full-automatic chemical luminescence immunoassay instrument, it is characterized in that comprising support body and control system, be provided with sample area on the described support body from left to right successively, the lath feed system, incubation district and lath detection system, below or the right side in described incubation district are provided with liquid-way system, the below in described incubation district, below or the right side of described lath detection system are provided with reagent area, described support body left side is provided with sample arm, the right side is provided with the reagent arm, be positioned at described lath feed system top on the described support body and be provided with first pusher arms, be positioned at inside, described incubation district and be provided with second pusher arms, described lath feed system, the incubation district, the lath detection system, liquid-way system, sample arm, the reagent arm, first pusher arms and second pusher arms are electrically connected with described control system respectively.
2. full-automatic chemical luminescence immunoassay instrument as claimed in claim 1, it is characterized in that described lath feed system comprises the lath frame, advances panel assembly, plate taking device and application of sample snubber assembly, describedly advance panel assembly, plate taking device and application of sample snubber assembly and all be fixed on the described support body, described plate taking device is located at the described panel assembly rear of advancing, described application of sample snubber assembly is located between described plate taking device and the described incubation district, describedly advances panel assembly, plate taking device and application of sample snubber assembly and is electrically connected with described control system respectively; Describedly advance panel assembly and comprise shell, storehouse door, first motor and first slide mechanism, put into the bottom of described shell after the user is placed on lath on the described lath frame from the storehouse door, under the drive of first motor, by first slide mechanism lath frame is lifted to the top of shell; Described plate taking device comprises handgrip, second motor and second slide mechanism, and described handgrip takes out the lath frame under the drive of second motor and second slide mechanism in shell; Described application of sample snubber assembly comprises application of sample buffer zone base, the 3rd motor and the 3rd slide mechanism, lath on the described lath frame moves on the described application of sample buffer zone base by first pusher arms, moving linearly under the drive of the 3rd motor and the 3rd slide mechanism, and carry out application of sample by sample arm.
3. full-automatic chemical luminescence immunoassay instrument as claimed in claim 2, it is characterized in that described incubation district comprises the lucifuge shell, incubation district base, the 4th motor, the 4th slide mechanism and second pusher arms, described incubation district base, the 4th slide mechanism and second pusher arms all are located at described lucifuge shell inside, lath behind the application of sample is moved on the incubation district base from application of sample buffer zone base, under the drive of the 4th motor and the 4th slide mechanism, shake, described second pusher arms is provided with sensitization liquid sample needle, described liquid-way system comprises sensitization liquid and cleaning fluid, is connected with described sensitization liquid phase by ram pump.
4. full-automatic chemical luminescence immunoassay instrument as claimed in claim 3, it is characterized in that described lath detection system comprises detection module, sliding block, lath driver module and lath active module, described detection module is positioned at described lath active module top, and described sliding block slides and is located at described lath driver module top.
5. full-automatic chemical luminescence immunoassay instrument as claimed in claim 4, it is characterized in that described lath active module comprises lath chute, Qianmen and back door, described lath is located in the described lath chute, an end of described lath chute is located at described Qianmen by the Qianmen resetting-mechanism, the bottom of the described lath chute other end is provided with fluting, described fluting top is located at by the back door resetting-mechanism in described back door, and described Qianmen is provided with jack, and described back door is provided with slot.
6. full-automatic chemical luminescence immunoassay instrument as claimed in claim 5, it is characterized in that described sliding block comprises fixed head, the lath fixation fork, direct current generator and leading screw, described lath fixation fork is slidingly connected by slide rail and described fixed head, described direct current generator is fixed on the fixed head, and be provided with driving gear at output terminal, described leading screw one end is connected with described lath fixation fork, the other end is provided with follower gear, described driving gear and follower gear are meshed, one side of described lath fixation fork is provided with the Qianmen inserted link, described Qianmen inserted link inserts in the jack at described Qianmen when needs drive the Qianmen, the lower surface of described lath fixation fork is provided with the back door inserted link, described back door inserted link inserts in the slot at described back door when needs drive the back door, described lath fixation fork is provided with some inserted sheets, described lath chute wall is provided with groove, and described inserted sheet passes described groove and inserts between the gap on the described lath.
7. full-automatic chemical luminescence immunoassay instrument as claimed in claim 6, it is characterized in that described full-automatic chemical luminescence immunoassay instrument also comprises dilution vibration district, described dilution vibration district is fixed on the described support body, and between described sample area and lath feed system.
8. as each described full-automatic chemical luminescence immunoassay instrument of claim 2-7, it is characterized in that described lath frame lower surface is provided with two blocks, fillet is fallen at the two ends of described block.
9. full-automatic chemical luminescence immunoassay instrument as claimed in claim 8 is characterized in that being equipped with clamp clip on described application of sample buffer zone base and the incubation district base, and described lath chute is provided with clamp clip, all fixes by screw.
10. full-automatic chemical luminescence immunoassay instrument as claimed in claim 9 is characterized in that described support body outside is provided with housing.
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| CN104215783A (en) * | 2014-05-21 | 2014-12-17 | 凯和生物科技(上海)有限公司 | Strip type immune fully-automatic analyzer |
| CN106199025A (en) * | 2016-01-18 | 2016-12-07 | 深圳雷杜生命科学股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN107831322A (en) * | 2017-12-08 | 2018-03-23 | 郑州科蒂亚生物技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter device |
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Denomination of invention: Fully-automatic chemiluminescent immunoassay analyzer Effective date of registration: 20151225 Granted publication date: 20140910 Pledgee: Bank of Hangzhou, Limited by Share Ltd, Jiaxing branch Pledgor: Jiaxing Quest Life Science Co., Ltd. Registration number: 2015990001162 |
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