CN110470854A - Automatic lmunoassays analyzer - Google Patents
Automatic lmunoassays analyzer Download PDFInfo
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- CN110470854A CN110470854A CN201810448922.7A CN201810448922A CN110470854A CN 110470854 A CN110470854 A CN 110470854A CN 201810448922 A CN201810448922 A CN 201810448922A CN 110470854 A CN110470854 A CN 110470854A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/021—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a flexible chain, e.g. "cartridge belt", conveyor for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0489—Self-propelled units
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of automatic lmunoassays analyzer, including sample-adding module and incubation module, sample-adding module includes the sample-adding local area set gradually along lath moving direction and reagent adding area, and lath can be moved to reagent adding area from sample-adding local area with straight path；Lath can also be moved to incubation module from reagent adding area, and lath can be from module resets be incubated to reagent adding area.Automatic lmunoassays analyzer disclosed by the invention simplifies mechanical structure, improves detection efficiency.
Description
Technical field
The present invention relates to technical field of medical equipment, more particularly, to a kind of automatic lmunoassays analyzer.
Background technique
Immunology detection be based on antigen and antibody specific reaction principle carry out, due to its can use isotope,
Enzyme, chemiluminescent substance etc. carry out display or the amplification of signal to measured object, therefore are commonly used for detecting protein, hormone etc. micro-
Measure bioactive substance.
Chemiluminescence immune assay is then to develop relatively rapid on-radiation immunoassay technology in recent years, and principle is benefit
The amplification of signal is carried out with chemiluminescent substance, and by its luminous intensity, immune cohesive process is directly measured, the method
Have become one of the important directions of immunology detection.But existing immunoassay apparatus generallys use turntable structure, preparation to
When sample, sample-adding is just able to achieve after needing equal turntables to rotate to specific position, and this is operated with reagent adding, and not only structure is complicated, and
Detection time is long, low efficiency.And existing detector often cannot achieve and return to reagent adding area addition reagent after incubation, it can not
Realize that three the steps even purpose of multi-step incubation, the degree of automation are low.
Summary of the invention
For the above-mentioned technical problem in the presence of the prior art, the invention proposes a kind of automatic lmunoassays analyzer,
The automatic lmunoassays analyzer includes:
It is loaded module, is used to sample and reagent being added to lath；
Module is incubated, is used to provide suitable environment temperature for immune response；
The sample-adding module includes the sample-adding local area set gradually along lath moving direction and reagent adding area, and lath can be from
The sample-adding local area is moved to the reagent adding area with straight path；Lath can also be moved to the temperature from the reagent adding area
Module is educated, and the lath can be from the incubation module resets to the reagent adding area.
In one embodiment, the lath is pushed to by the first delivery device from the sample-adding local area with straight path
The reagent adding area.
In one embodiment, first delivery device includes that the first push rod, the first sliding unit and the first driving are single
Member, first push rod can be slided along the first sliding unit, and first push rod can be by lath from the sample-adding local area
The reagent adding area is pushed to straight path, first driving unit is for driving the first sliding unit mobile.
In one embodiment, it is equipped with the first transhipment channel between the sample-adding local area and the reagent adding area, described the
Lath after the completion of being loaded originally is pushed to described add via first transhipment channel from the sample-adding local area by one delivery device
Reagent area.
In one embodiment, the lath is moved to incubation module from the reagent adding area by the second delivery device,
And the lath pushes back to reagent adding area from the incubation module by second delivery device.
In one embodiment, the incubation module includes the first incubation unit and second incubates unit, first temperature
It educates and is provided with the second transhipment channel between unit and the second incubation unit.
In one embodiment, which further includes detection module, is used to carry out sample to be tested
Detection is equipped with third and transports channel, carrying to test sample after the completion of incubating between the incubation module and the detection module
The lath of product is moved to detection module via third transhipment channel.
In one embodiment, the lath for carrying sample to be tested after the completion of the incubation by third delivery device or
Person's mechanical arm is moved to detection module via third transhipment channel.
In one embodiment, it is additionally provided with solid-liquid displacement zone between the second incubation unit and the detection module, examined
The lath for carrying sample to be tested after the completion of survey is completed to be separated by solid-liquid separation in the solid-liquid displacement zone, and completes after being separated by solid-liquid separation
Lath is abandoned in the solid-liquid displacement zone.
In one embodiment, the detection module includes:
Unit is excited, for emitting exciting light；
Reading cell, for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute into
Row acquisition process.
In one embodiment, the excitation unit includes exciter, and the exciter can emit 600~700nm's
Red exciting light, the reading cell include single photon counter, photomultiplier tube, silicon photocell or light-measuring integrating sphere.
In one embodiment, which further includes general liquid loading module, for adding general liquid
It adds on the lath.
In one embodiment, the lath completes the load of general liquid in second transhipment channel.
In one embodiment, which further includes general liquid disk, is contained in the general liquid disk
General liquid.
In one embodiment, which further includes reagent disc, the automatic lmunoassays analyzer structure
It makes as Dual-layer structure, the lower section in the reagent adding area is arranged in the reagent disc, and the general liquid disk is positioned close to institute
State the lower section of general liquid loading module.
In one embodiment, which further includes grillage supplying module, the grillage supplying module
It is described to take grillage mechanism that carry the grillages of blank plates from described including taking grillage mechanism, storehouse and the 4th delivery device
It is taken out in storehouse, the 4th delivery device is used to the blank plates taken out from the storehouse pushing to sample-adding local area.
In one embodiment, which further includes pre-dilution module, and the pre-dilution module is used for
Pre-dilution processing is carried out to the solution comprising sample to be tested.
Compared with prior art, of the invention to have the prominent advantages that, automatic lmunoassays analyzer disclosed by the invention is adding
Rotary-disk type structure has been abandoned when adding sample to be tested and reagent, lath is transported to from sample-adding mechanism by reagent adding using straight path
Mechanism, the preparation process for the completion sample to be tested being simple and efficient, reduces manufacturing cost, simplifies installation, reduce failure rate.
Further, since lath can move back and forth between reagent adding mechanism and incubation module, so that of the present invention immune
Analyzer more automatically realizes three the steps even purpose of multi-step incubation.
Other features and advantages of the present invention will be illustrated in the following description, also, partial becomes from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention can be by specification, right
Specifically noted structure is achieved and obtained in claim and attached drawing.
Detailed description of the invention
The preferred embodiment of the present invention is described in detail below in conjunction with attached drawing.In figure:
Fig. 1 is a kind of structural schematic diagram one of automatic lmunoassays analyzer according to the present invention.
Fig. 2 is the lath supply schematic diagram of the sample-adding module and incubation module in Fig. 1.
Fig. 3 is the first delivery device schematic diagram according to the present invention.
Fig. 4 is the structural schematic diagram that light according to the present invention swashs reading module.
Fig. 5 is the side view that light according to the present invention swashs reading module.
Fig. 6 is the structural schematic diagram of the reception photoswitch in Fig. 4.
Fig. 7 is the structural schematic diagram of reagent disc of the present invention.
Fig. 8 is the structural schematic diagram of grillage supplying module of the present invention.
Fig. 9 is a kind of structural schematic diagram two of automatic lmunoassays analyzer according to the present invention.
Appended drawing reference: 11- is loaded local area；The 5th sliding block of 111-；12- reagent adding area；13- first transports channel；14- first
Sample arm；The second sample arm of 15-；2- incubates module；21- first incubates unit；22- second incubates unit；The transhipment of 23- second is logical
Road；24- third transports channel；The solid-liquid displacement zone 25-；3- detection module；31- excites unit；311- excitation light switch；3111-
Rotating part；3112- through-hole；32- reading cell；321- receives photoswitch；3211- baffle；The first circular hole of 3212-；3213- second
Circular hole；The first rotation section 3214-；The second rotation section 3215-；33- optical path component；331- control device；332- half-reflecting half mirror；
333- lens；334- optical filter；34- opening；The first delivery device of 4-；The first push rod of 41-；The first sliding block of 42-；43- first is sliding
Rail；The first synchronous belt of 44-；45- first motor；5- grillage supplying module；The 4th delivery device of 50-；The 4th push rod of 501-；502-
Four-slider；The 4th optical axis of 503-；The 4th synchronous belt of 504-；The 4th fixed block of 505-；The 4th motor of 506-；51- takes grillage machine
Structure；The second optical axis of 511-；The second synchronous belt of 512-；The second fixed block of 513-；514- bottom plate；52- storehouse；53- grillage；The bottom 514-
Plate；6- pre-dilution module；7- sample carrier；The first reagent disc of 8-；The second reagent disc of 10-；101- opening device；102- rotating part
Part；103- scanner section；104- test chamber；The general liquid disk of 20-；The 5th delivery device of 30-；The 6th delivery device of 40-.
In the accompanying drawings, identical component uses identical appended drawing reference.The attached drawing is not drawn according to the actual ratio.
Specific embodiment
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings and examples, how to apply to the present invention whereby
Technological means solves technical problem, and the realization process for reaching technical effect can fully understand and implement.It needs to illustrate
As long as not constituting conflict, each feature in each embodiment and each embodiment in the present invention can be combined with each other,
It is within the scope of the present invention to be formed by technical solution.
Fig. 1 provides a kind of automatic lmunoassays analyzer according to the present invention, as shown in Figure 1 comprising sample-adding module and
Incubate module 2.Sample-adding module is used to sample and reagent being added to blank plates.Module 2 is incubated to be used for hold on lath
The sample and reagent of load occur chemiluminescence immunoassay reaction and provide suitable environment temperature.
Wherein, sample-adding module includes the sample-adding local area 11 set gradually along lath moving direction and reagent adding area 12, lath
Reagent adding area 12 can be moved to from sample-adding local area 11 with straight path.Lath can also be moved to incubation mould from reagent adding area 12
Block 2, and reagent adding area 12 can be reset to from module 2 is incubated.
In the present invention, the sample includes but is not limited to sample to be tested and the solution comprising sample to be tested.Reagent includes
But be not limited to dilution, cleaning solution, general liquid, reaction reagent or solvent etc..
The temperature that can usually use is incubated as 43 DEG C, 37 DEG C, room temperature or 4 DEG C, 37 DEG C are common temperature in laboratory
Educate the optimal reactive temperature of temperature and the combination of most of antigen-antibodies.In most cases, antigen-antibody reaction is generally at 37 DEG C
After 1-2 hours, the product of generation is up to peak.To accelerate reaction, reaction can be improved in a certain range in experimentation
Temperature and during the reaction continuous oscillation come increase antigen-antibody contact probability.
The automatic lmunoassays analyzer has abandoned rotary-disk type structure when preparing sample to be tested, using straight path by lath
It is transported to reagent adding mechanism from sample-adding mechanism, the preparation process for the completion sample to be tested being simple and efficient reduces manufacturing cost,
Installation is simplified, failure rate is reduced.Further, since lath can move back and forth between reagent adding mechanism and incubation module,
So that three step of the realization even purpose of multi-step incubation that the analyzer more automates.
In one embodiment, as shown in Fig. 2, lath passes through the first delivery device 4 from sample-adding local area 11 with straight path
Push to reagent adding area 12.There is first delivery device 4, so that lath is directly moved to from sample-adding local area 11 with linear distance
Reagent adding area 12 avoids when preparing sample to be tested using rotary-disk type structure in the past, and analyzer has to specific until turntable
Region could be loaded when rotating to predeterminated position and reagent adding.
In one embodiment, as shown in figure 3, the first delivery device 4 includes the first push rod 41, the first sliding unit and the
One driving unit, the first push rod 41 can be slided along the first sliding unit, and can push lath from sample-adding local area 11 with straight line
Track pushes to reagent adding area 12, and the first driving unit is for driving the first sliding unit mobile.Specifically, the first sliding unit
Including the first sliding block 42 and the first sliding rail 43, the first sliding block 42 is connect by the first synchronous belt 44 with first motor 45, and first is sliding
Block 42 can be slided along the first sliding rail 43.First sliding block 42, which is able to drive the promotion lath of push rod 41 and is moved to from sample-adding local area 11, to be added
Reagent area 12.
In one embodiment, as depicted in figs. 1 and 2, it is loaded between local area 11 and reagent adding area 12 and is equipped with the first transhipment
Channel 13, the first delivery device 4 push to the lath after the completion of being loaded originally from sample-adding local area 11 via the first transhipment channel 13
Reagent adding area 12.
In one embodiment, lath is moved to from reagent adding area 12 by the second delivery device and incubates module 2, and is passed through
Second delivery device pushes back to reagent adding area 12 from module 2 is incubated.The structure of second delivery device can be with the first delivery device
Structure it is identical, the lath after incubation need to return reagent adding area 12 add additive reagent when, as long as control the second delivery device
In motor reversal.The structure of second delivery device can be identical as the structure of the first delivery device, can also be under
The structure for stating the 4th delivery device is identical.
In one embodiment, as shown in Figure 1, incubating module 2 includes that the first incubation unit 21 and second incubate unit 22.
In one embodiment, as shown in Figure 1, being provided with second between the first incubation unit 21 and the second incubation unit 22
Transport channel 23.
In one embodiment, as shown in Figure 1, the automatic lmunoassays analyzer further includes detection module 3, for treating test sample
Product are detected.
In one embodiment, channel 24 is transported as shown in Figure 1, incubating and being equipped with third between module 2 and detection module 3,
The lath for carrying sample to be tested after the completion of incubation is moved to detection module 3 via third transhipment channel 24.
In one embodiment, the lath for carrying sample to be tested after the completion of incubating is by third delivery device via the
Three transhipment channels 24 are moved to detection module 3, it can also be transported channel via third by mechanical arm and be moved to detection
Module.The structure of the third delivery device can be identical as the structure of the first delivery device, can also be with following 4th pushers
The structure of structure is identical.
In one embodiment, solid-liquid displacement zone 25 is additionally provided between the second incubation unit 22 and detection module 3.If no
Rereading is needed, then after the completion of reading, the lath for carrying sample to be tested is completed to be separated by solid-liquid separation in solid-liquid displacement zone 25, and
The lath after being separated by solid-liquid separation will be completed to abandon in solid-liquid displacement zone 25.If there is rereading, then will complete to read for the first time
Lath after number is retracted along former track after third transhipment channel 24 removes and is again introduced into the progress rereading of detection module 3.
In one embodiment, as shown in figure 4, detection module 3 includes excitation unit 31 and reading cell 32.Excite unit 31
For emitting exciting light.Reading cell 32 is used to receive the optical signal issued after sample to be tested is excited, and received to institute
Optical signal is acquired processing.In the case of this kind, automatic lmunoassays analyzer disclosed by the invention is full-automatic light activation hair
Optical detector.It should be understood that automatic lmunoassays analyzer disclosed by the invention is also possible to full-automatic magnetic microparticle chemiluminescence
Detector or other Full-automatic chemiluminescence analyzers.
Light-induced chemiluminescent method is one of common method of chemiluminescence analytical technique, can be used for immunoassay detection, faces
It is mainly used for the detection of disease on bed.It is combined in a certain range by photosensitive particulate and luminous particle, generates ion-oxygen energy
The transmitting of amount issues optical signal, to detect to sample to be tested.Wherein, Photoactive compounds are filled with inside photosensitive particulate,
And luminophor and lanthanide series are filled with inside luminous particle.It is photosensitive under the excitation of red laser (600~700nm)
Particle releases the singlet oxygen ion (4 μ S) of upper state, and propagation distance is about 200nm.When photosensitive particulate and luminous particle
Distance it is close enough when, the singlet oxygen ion of photosensitive particulate release can reach luminous particle, and pass through a series of chemistry
Reaction, launches the light of 520~620nm high level, and is detected by instrument.In this reaction system, the concentration of particle is very low,
Collision probability is smaller, and background signal is faint.Only after photosensitive particulate and luminous particle are combined by immune response, Cai Huifa
Apparent light is projected, therefore the sensitivity of system is very high.In medical diagnosis on disease, common detection pattern includes three to four groups
Point: the luminous particle of envelope antigen or antibody, the antigen of biotin or digoxigenin labeled or antibody, Avidin or anti-digoxin packet
The photosensitive particulate of quilt neutralizes antigen or antibody etc..The above each component passes through the above incubation reaction of two steps and determined antigen or antibody
In conjunction with, and sample to be tested is qualitatively or quantitatively detected by the power of chemiluminescence amount.With traditional ELISA
Method is compared, it has the characteristics that homogeneous, high sensitivity and easy to operate is easy to automate.Therefore, application prospect is very wide
It is wealthy.
In this embodiment, excitation unit 31 includes exciter, and exciter can emit the red excitation of 600~700nm
Light；Reading cell 32 includes single photon counter, photomultiplier tube, silicon photocell or light-measuring integrating sphere.
In a preferred embodiment, as shown in figure 5, excitation unit 31 is other than including exciter, it further include exciting light
Switch 311, excitation light switch 311 are used to control the conducting and blocking of the exciting light emitted by excitation unit.
In one embodiment, as shown in figure 5, excitation light switch 311 includes rotating part 3111, on the side wall of rotating part 3111
There are two through-hole 3112, two through-holes 3112 to pass through the axle center of rotating part 3111 for tool.When the line of two through-holes 3112 is vertical,
Excitation light switch 311 is in the open state, excites light conduction, and exciting light can be irradiated to by through-hole 3112 to be located under opening 34
On the sample to be tested of side.When the line of two through-holes 3112 is non-vertical, excitation light switch 311 is in close state, exciting light
It is blocked, exciting light can not be irradiated on the sample to be tested for being located at 34 lower section of opening.
In a preferred embodiment, reading cell 32 includes receiving photoswitch 321, receives photoswitch 321 for controlling
The conducting or blocking of sample to be tested generated optical signal after being excited.
In one embodiment, as shown in fig. 6, receiving photoswitch 321 includes baffle 3211 and crank and rocker mechanism, baffle
3211 lower part is equipped with the first circular hole 3212；The lower part of crank and rocker mechanism is equipped with the second circular hole 3213, crank and rocker mechanism
Movement enables the first circular hole 3212 and the second circular hole 3213 to overlap, when 3213 phase of the first circular hole 3212 and the second circular hole
It when being mutually overlapped, receives photoswitch 321 and opens, when the first circular hole 3212 and the second circular hole 3213 are not overlapped, receive photoswitch
321 close.
In this embodiment, crank and rocker mechanism includes the first rotation section 3214 and the second rotation section 3215, the first rotation
Portion 3214 is fixed on baffle 3211；Second rotation section 3215 is rotatablely connected the first rotation section 3214, the second circular hole 3213
The lower part of second rotation section 3215 is set.First rotation section 3214 rotates under the drive of the drive, and drives second turn
Dynamic portion 3215 rotates, so that when the second circular hole 3213 turns to the position of corresponding first circular hole 3212, the first circular hole
3212 and second circular hole 3213 overlap.
In one embodiment, as shown in figure 4, excitation light switch 311 and reception photoswitch 321 are all connected with control device 331,
Control device 331 receives photoswitch 321 and closes, and work as and receive photoswitch 321 for making when excitation light switch 311 is connected
When conducting, excitation light switch 311 is closed.Preferably, control device 331 is driver, and one end of the driver connects exciting light
Switch 311, other end connection receives photoswitch 321, when connection, needs so that rotary driver in any case, excitation light switch 311
It all can not be in the open state simultaneously with photoswitch 321 is received.
In one embodiment, as shown in figure 4, the detection module 3 further includes optical path component 33, optical path component includes along reception
Half-reflecting half mirror 332, lens 333 and the optical filter 334 that the direction of light is set gradually, half-reflecting half mirror 332 are arranged in exciting light
Channel and the intersection for receiving optical channel.Half-reflecting half mirror 332 can not only be ended non-targeted by the exciting light of target wavelength
The exciting light of wavelength, while the luminous signal of target wavelength caused by sample to be tested can be reflected.Preferably, half-reflecting half mirror
With the intersection of 45 degree of overturning angle setting exciting lights and reception light.Through half-reflecting half mirror 332 reflect as produced by sample to be tested
Optical signal enter reading cell 32 by lens.
In a preferred embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes that general liquid adds
Module is carried, for general liquid to be added to lath.Preferably, general liquid loading module is equipped with independent third sample arm (figure
In be not shown).Under normal conditions, lath from first incubation unit 21 be moved to the second incubation unit 22 during, second
It transports in channel 23 and general liquid is added by third sample arm.
In a preferred embodiment, as shown in Figure 1, automatic lmunoassays analyzer further includes reagent disc 10, reagent disc
Reagent to be added is held in 10.
In one embodiment, as shown in fig. 7, the upper end opening of reagent disc 10 is configured to circle.Reagent disc 10 includes spacious
Mouth device 101 and the rotary part 102 that the bottom of open device 101 is set and open device 101 is driven to rotate, open device
Scanner section 103 is provided on 101 side wall, scanning means can identify the category of open 101 interior reagent of device by scanner section 103
Property.Scanner section 103 is the through-hole for being provided with open 101 side of device, and the reagent inside open device 101 is arranged in test chamber
In 104, the label on test chamber 104 can be revealed by through-hole.Wherein, test chamber 104 can be reagent bottle, examination
Pipe, beaker or flask etc..Scanner section 103 is flushed with the height of the label on test chamber 104, can facilitate scanning means, example
Such as card reader or scanner, the label on test chamber 104 is scanned, so as to avoid the identification of operator's manual scanning
The step of, reduce the risk of error.Scanning means is by the test chamber of the current location scanned (i.e. at reagent suction port)
Information be sent in controller, controller is judged, whether the reagent in the test chamber of current location is required examination
Agent, if so, reagent arm acts；If it is not, then rotary part is driven to be rotated, go to the test chamber of the next position currently
Position simultaneously repeats the above process, therefore by above-mentioned automatically scanning function, is able to maintain the consistency of result.Rotary part band
Dynamic opening device 101 and its internal test chamber 104 rotate together with, and so that test chamber 104 is reached reagent suction port, to try
Agent arm draws reagent from test chamber.The reagent disc is by opening up scanner section on the side wall of open device, whenever reagent position
In current location, scanning means can identify that attribute of current location reagent, such as the type of reagent etc. are believed by scanner section
Breath, therefore the step of reagent is taken out simultaneously manual scanning by operator in conventional method from open device is omitted, it can drop
The risk of low error, and guarantee the consistency of reagent.
In this embodiment, as shown in Figure 1, automatic lmunoassays analyzer further includes general liquid disk 20, in general liquid disk 20
It is contained with general liquid.General liquid can be the solution including photosensitive microballoon.Third mechanical arm draws general liquid out of general liquid disk,
And it adds it on the lath in the second transhipment channel.
In this embodiment, as shown in Figure 1, automatic lmunoassays analyzer is configured to Dual-layer structure, 10 He of reagent disc
The general setting of liquid disk 20 is loaded local area 11, reagent adding area 12, incubation module 2 and detection module 3 and is arranged on upper layer in lower layer.Tool
Body, the lower section in reagent adding area 12 is arranged in reagent disc 10, and general liquid disk 20 is positioned close to the lower section of general liquid loading module.
This kind of Dual-layer design, can shorten size together, so that the even closer smoothness of the cooperation between each component, thus further
Improve detection efficiency.
In a preferred embodiment, as shown in Figure 1, automatic lmunoassays analyzer further includes grillage supplying module 5.It should
Grillage supplying module 5 is for providing blank plates.
In one embodiment, as shown in figure 8, grillage supplying module 5 includes that grillage mechanism 51, storehouse 52 and the 4th is taken to push away
Mechanism 50 is sent, takes grillage mechanism 51 to take out the grillage for carrying blank plates from storehouse 52, the 4th delivery device 50 is used for
The blank plates taken out from storehouse 52 are pushed into sample-adding local area 11.Grillage 53 successively overlays in storehouse 52, takes when above-mentioned
As soon as grillage mechanism 51 often takes out laminate frame 53 from the top of storehouse 52, then grillage transmission mechanism drives storehouse 52 to rise a position
Set namely an adjacent grillage 53 between height.Successively the grillage 53 of a file is taken in this way, then one file of artificial threading
Grillage 53.
Grillage mechanism 51 is taken to include the second sliding block (positioned at the lower section of grillage 53, being not shown in the figure) and the second optical axis 511, the
Two sliding blocks are connect by the second synchronous belt 512 with the second motor (not shown), and the second sliding block can be along the second optical axis 511
Sliding, the both ends of the second optical axis 511 pass through the second fixed block 513 and are fixed on bottom plate 514.The upper surface of second sliding block is equipped with
Handgrip, handgrip can take out grillage 53 from storehouse 52, and move under the drive of the second sliding block.
4th delivery device 50 includes the 4th push rod 501, the 4th sliding unit and the 4th driving unit, the 4th push rod 501
It can be slided along the 4th sliding unit, and blank plates can be pushed to be moved to sample-adding local area 11, the 4th driving unit is for driving
Dynamic 4th sliding unit is mobile.4th sliding unit includes Four-slider 502 and the 4th optical axis 503, and Four-slider 502 passes through the
Four synchronous belts 504 are connect with the 4th motor 506, and Four-slider 502 can be slided along the 4th optical axis 503, the 4th optical axis 503
Both ends pass through the 4th fixed block 505 and are fixed in pusher arms 507.
4th delivery device 50 is completed on the blank plates push-in sample-adding local area 11 on grillage 53 when a lath pushes
Afterwards, the 5th sliding block 111 drives the width between the mobile adjacent slat of lath clamping device 112 on sample-adding local area 11, together
When, the first sliding block drives grillage 53 to move equally the width between an adjacent slat, so that push rod 501 can push down
On one lath to sample-adding local area 11.
In a preferred embodiment, pre- dilute as shown in Figure 1, automatic lmunoassays analyzer further includes pre-dilution module 6
Module 6 is released for carrying out pre-dilution processing to the solution comprising sample to be tested.Preferably, pre-dilution module 6 includes pre-dilution plate
(not shown) and oscillator (not shown) control sample arm when the solution comprising sample to be tested needs pre-dilution
The solution is added in the pre-dilution plate in pre-dilution module 6, oscillator is then controlled and oscillation treatment is carried out to pre-dilution plate,
With the solution comprising sample to be tested after being diluted.
In the automatic lmunoassays analyzer shown in above-mentioned, the main flow of detection includes:
1) grillage mechanism 51 is taken to take out the grillage 53 for carrying blank plates from storehouse 52；
2) blank plates are pushed into sample-adding local area 11 by the 4th delivery device 50 from storehouse 53, complete sample in sample-adding local area 11
This addition；
3) lath for having added sample to be tested is pushed to reagent adding area 12, In from sample-adding local area 11 by the first delivery device 4
The addition of the completion of reagent adding area 12 reagent；
4) the second delivery device will add after reagent lath and push to the first incubation unit 21 from reagent adding area 12, and
First, which incubates unit 21, completes first step incubation；
5) lath for carrying sample to be tested after incubating the first step is moved to the second incubation from the first incubation unit 21
Unit 22 carries out second step incubation, in moving process, when carrying the lath of sample to be tested by the second transhipment channel, adds
Add general liquid.
6) third delivery device pushes the lath for carrying sample to be tested after the completion of incubation from the second incubation unit 22
To detection module 3, read in detection module 3.
If needing to add additive reagent in the lath for carrying sample to be tested after completing first step incubation, then passing through
The lath for carrying sample to be tested is retracted into reagent adding area 12 and adds additive reagent by the second delivery device, has added additive reagent
Afterwards, 4) -6 are repeated the above process).
In one embodiment, as shown in figure 9, sample-adding module further includes the first sample arm 14 and the second sample arm 15,
In, the first sample arm 14 is for adding the solution comprising sample to be tested, and the second sample arm 15 is for adding reaction reagent.First adds
Needle pond (not shown) can be washed by first after the completion sample-adding movement of sample arm 14 to be cleaned, the second sample arm 15 plus reaction examination
Needle pond (not shown) can be washed by second after the completion of agent to be cleaned.Therefore in this embodiment, 14 He of the first sample arm
Second sample arm 15 can carry out sample-adding to lath simultaneously and originally operate with reagent adding, avoid and had in turntable structure until turning
Lath on disk can just be added the solution comprising sample to be tested or addition reaction reagent operation after rotating to designated position,
So as to shorten detection time.
It in this embodiment, further include sample carrier 7, the sample carrier 7 is for carrying sample to be detected.
In one embodiment, it as shown in figure 9, the blank plates taken out from storehouse 52 push to sample-adding local area 11, holds
The lath for being loaded with the solution comprising sample to be tested pushes to reagent adding area 12 from sample-adding local area 11 and carries mixed solution
Lath pushes to the first incubation unit 21 from reagent adding area 12 and is completed by same delivery device, which is denoted as the 5th and pushes away
Mechanism 30 is sent, structure can be identical as the first delivery device 4, can also be identical as the 4th delivery device 50.
It should be understood that above-mentioned push step can also be realized by three independent delivery devices respectively, although independent
Three kinds of delivery devices can increase the flexibility that detector transports lath, but this kind setting will increase the complexity of mechanical structure
Property, cause detector volume to increase, while manufacturing cost increases.
In this embodiment, it is moved to the second incubation unit 22 from the first incubation unit 21 via the second transhipment channel 23,
And be moved to detection module 3 via third transhipment channel 24 from the second incubation unit 22 and also completed by same delivery device, it should
Delivery device is denoted as the 6th delivery device 40, and structure can be identical as the first delivery device 4, can also be with the 4th delivery device
50 is identical.
The foregoing is merely the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, Ren Heben
The technical staff in field can be easy to carry out and be altered or varied in technical scope disclosed by the invention, and this change or change
Change should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (17)
1. a kind of automatic lmunoassays analyzer characterized by comprising
It is loaded module, is used to sample and reagent being added to lath；
Module is incubated, is used to provide suitable environment temperature for immune response；
The sample-adding module includes the sample-adding local area set gradually along lath moving direction and reagent adding area, and lath can be from described
It is loaded local area and the reagent adding area is moved to straight path；Lath can also be moved to the incubation mould from the reagent adding area
Block, and the lath can be from the incubation module resets to the reagent adding area.
2. automatic lmunoassays analyzer according to claim 1, which is characterized in that the lath passes through the first delivery device
The reagent adding area is pushed to from the sample-adding local area with straight path.
3. automatic lmunoassays analyzer according to claim 2, which is characterized in that first delivery device includes first
Push rod, the first sliding unit and the first driving unit, first push rod can be slided along the first sliding unit, and described first
Lath can be pushed to the reagent adding area from the sample-adding local area with straight path by push rod, and first driving unit is used for
Drive the first sliding unit mobile.
4. automatic lmunoassays analyzer according to claim 3, which is characterized in that the sample-adding local area and the reagent adding
Between area be equipped with first transhipment channel, first delivery device by be loaded this after the completion of lath from the sample-adding local area via
First transhipment channel pushes to the reagent adding area.
5. automatic lmunoassays analyzer according to claim 1, which is characterized in that the lath passes through the second delivery device
It is moved to incubation module from the reagent adding area, and the lath is pushed back by second delivery device from the incubation module
To reagent adding area.
6. automatic lmunoassays analyzer according to claim 1, which is characterized in that the incubation module includes the first incubation
Unit and second incubates unit, is provided with the second transhipment channel between the first incubation unit and the second incubation unit.
7. automatic lmunoassays analyzer according to claim 6, which is characterized in that further include detection module, be used for pair
Sample to be tested is detected；It is equipped with third between the incubation module and the detection module and transports channel, after the completion of incubating
The lath for carrying sample to be tested is moved to detection module via third transhipment channel.
8. automatic lmunoassays analyzer according to claim 7, which is characterized in that after the completion of the incubation carry to
The lath of sample transports channel via the third by third delivery device or mechanical arm and is moved to detection module.
9. automatic lmunoassays analyzer according to claim 8, which is characterized in that described second incubates unit and the inspection
It surveys between module and is additionally provided with solid-liquid displacement zone, the lath for carrying sample to be tested after the completion of detecting is complete in the solid-liquid displacement zone
At separation of solid and liquid, and completes the lath after being separated by solid-liquid separation and abandoned in the solid-liquid displacement zone.
10. automatic lmunoassays analyzer according to claim 7, which is characterized in that the detection module includes:
Unit is excited, for emitting exciting light；
Reading cell is adopted for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute
Collection processing.
11. automatic lmunoassays analyzer according to claim 10, which is characterized in that the excitation unit includes excitation
Device, the exciter can emit the red exciting light of 600~700nm, and the reading cell includes single photon counter, photoelectricity
Multiplier tube, silicon photocell or light-measuring integrating sphere.
12. automatic lmunoassays analyzer according to claim 1, which is characterized in that further include general liquid loading module, use
It is added on the lath in by general liquid.
13. automatic lmunoassays analyzer according to claim 6, which is characterized in that the lath is in second transhipment
The load of general liquid is completed in channel.
14. automatic lmunoassays analyzer according to claim 12, which is characterized in that it further include general liquid disk, it is described logical
With being contained with general liquid in liquid disk.
15. automatic lmunoassays analyzer according to claim 14, which is characterized in that further include reagent disc, it is described it is complete from
Dynamic immunity analysis instrument is configured to Dual-layer structure, and the lower section in the reagent adding area, the general liquid is arranged in the reagent disc
Disk is positioned close to the lower section of the general liquid loading module.
16. automatic lmunoassays analyzer according to claim 1, which is characterized in that it further include grillage supplying module, it is described
Grillage supplying module includes taking grillage mechanism, storehouse and the 4th delivery device, described to take grillage mechanism that carry blank plates
Grillage taken out from the storehouse, the 4th delivery device is for pushing to the blank plates taken out from the storehouse
It is loaded local area.
17. automatic lmunoassays analyzer according to claim 1, which is characterized in that it further include pre-dilution module, it is described pre-
Module is diluted to be used to carry out pre-dilution processing to the solution comprising sample to be tested.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023056985A1 (en) * | 2021-10-09 | 2023-04-13 | 苏州国科均豪生物科技有限公司 | Incubation temperature control method for fluorescence immunoassay analyzer, and medium and pcr detection system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102183639A (en) * | 2011-03-14 | 2011-09-14 | 哈尔滨工业大学（威海） | Full-automatic chemiluminescence immunity analyzer |
| CN102944672A (en) * | 2012-11-16 | 2013-02-27 | 李方和 | Method for qualitatively and quantitatively detecting target substance to be detected in blood serum by utilizing light initiated chemiluminescence immune assay |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103267867A (en) * | 2013-05-09 | 2013-08-28 | 嘉兴凯实生物科技有限公司 | Fully-automatic chemiluminescent immunoassay analyzer |
| CN105403717A (en) * | 2015-12-30 | 2016-03-16 | 中国科学院苏州生物医学工程技术研究所 | Multiple-sample-injection incubation reaction mechanism with horizontally-pushing push rod |
| CN106980024A (en) * | 2017-03-28 | 2017-07-25 | 杭州凯坤科技有限公司 | A kind of full-automatic light-induced chemiluminescent detector |
| CN207147974U (en) * | 2017-08-15 | 2018-03-27 | 博阳生物科技（上海）有限公司 | A kind of immunoassay apparatus |
| CN208140724U (en) * | 2018-05-11 | 2018-11-23 | 博阳生物科技（上海）有限公司 | Automatic lmunoassays analyzer |
-
2018
- 2018-05-11 CN CN201810448922.7A patent/CN110470854A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102183639A (en) * | 2011-03-14 | 2011-09-14 | 哈尔滨工业大学（威海） | Full-automatic chemiluminescence immunity analyzer |
| CN102944672A (en) * | 2012-11-16 | 2013-02-27 | 李方和 | Method for qualitatively and quantitatively detecting target substance to be detected in blood serum by utilizing light initiated chemiluminescence immune assay |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103267867A (en) * | 2013-05-09 | 2013-08-28 | 嘉兴凯实生物科技有限公司 | Fully-automatic chemiluminescent immunoassay analyzer |
| CN105403717A (en) * | 2015-12-30 | 2016-03-16 | 中国科学院苏州生物医学工程技术研究所 | Multiple-sample-injection incubation reaction mechanism with horizontally-pushing push rod |
| CN106980024A (en) * | 2017-03-28 | 2017-07-25 | 杭州凯坤科技有限公司 | A kind of full-automatic light-induced chemiluminescent detector |
| CN207147974U (en) * | 2017-08-15 | 2018-03-27 | 博阳生物科技（上海）有限公司 | A kind of immunoassay apparatus |
| CN208140724U (en) * | 2018-05-11 | 2018-11-23 | 博阳生物科技（上海）有限公司 | Automatic lmunoassays analyzer |
Non-Patent Citations (1)
| Title |
|---|
| 王弼徒: "全自动化学发光免疫分析仪测控系统的研究", 《中国博士学位论文全文数据库信息科技辑》, 15 July 2012 (2012-07-15), pages 2 - 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023056985A1 (en) * | 2021-10-09 | 2023-04-13 | 苏州国科均豪生物科技有限公司 | Incubation temperature control method for fluorescence immunoassay analyzer, and medium and pcr detection system |
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| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 200131 3rd and 5th floors, building 1, No.88 Cailun Road, Pudong New Area pilot Free Trade Zone, Shanghai Applicant after: Kemei Boyang diagnostic technology (Shanghai) Co.,Ltd. Applicant after: Kemei Diagnostic Technology Co., Ltd Address before: 201210 the third and fifth floors of Building 1, No. 88, Cailun Road, Pudong New Area, Shanghai Applicant before: BEYOND DIAGNOSTICS (SHANGHAI) Co.,Ltd. Applicant before: Kemei Diagnostic Technology Co., Ltd |