CN110412258A - Full-automatic light-induced chemiluminescent detector - Google Patents
Full-automatic light-induced chemiluminescent detector Download PDFInfo
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- CN110412258A CN110412258A CN201810400851.3A CN201810400851A CN110412258A CN 110412258 A CN110412258 A CN 110412258A CN 201810400851 A CN201810400851 A CN 201810400851A CN 110412258 A CN110412258 A CN 110412258A
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- 230000032258 transport Effects 0.000 claims abstract description 33
- 238000001514 detection method Methods 0.000 claims abstract description 32
- 239000011521 glass Substances 0.000 claims abstract description 15
- 230000003287 optical effect Effects 0.000 claims description 33
- 239000003153 chemical reaction reagent Substances 0.000 claims description 25
- 230000007246 mechanism Effects 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 16
- 230000004308 accommodation Effects 0.000 claims description 8
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- 230000008676 import Effects 0.000 claims description 6
- 239000002355 dual-layer Substances 0.000 claims description 4
- 238000003018 immunoassay Methods 0.000 claims description 4
- 239000002699 waste material Substances 0.000 abstract description 3
- 238000011534 incubation Methods 0.000 abstract description 2
- 230000004913 activation Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 31
- 230000005284 excitation Effects 0.000 description 16
- 230000033001 locomotion Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000005081 chemiluminescent agent Substances 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses including that cup item transports module and the sharp reading module of light, cup item transport module, which is used to for the cup item for being contained with sample to be tested to be transported to light to swash, reads module；Light swashs reading module for recording the reflective reaction of light activation and reading to the sample to be tested after incubation；It includes cup transshipment acitivity and cup mounting base that cup item, which transports module, and the two sides of cup transshipment acitivity are arranged in cup mounting base, and the region that light swashs reading module is provided with cup mounting base.Full-automatic light-induced chemiluminescent detector disclosed by the invention uses cup item to transport module to transport the cup item for carrying reaction cup, traditional board-like cup item is abandoned, not only reduce resource waste, reduce detection cycle, also enable glass item to be simply and effectively transported to light and swashs reading cell, it reduces costs, simplifies structure.
Description
Technical field
The present invention relates to chemiluminescence immunoassay technology fields, examine more particularly, to a kind of full-automatic light-induced chemiluminescent
Survey instrument.
Background technique
Immunology detection be based on antigen and antibody specific reaction principle carry out, due to its can use isotope,
Enzyme, chemiluminescent substance etc. carry out display or the amplification of signal to measured object, therefore are commonly used for detecting protein, hormone etc. micro-
Measure bioactive substance.
Chemiluminescence immune assay is then to develop relatively rapid on-radiation immunoassay technology in recent years, and principle is benefit
The amplification of signal is carried out with chemiluminescent substance, and by its luminous intensity, immune cohesive process is directly measured, the method
Have become one of the important directions of immunology detection.But cup item used in existing light-induced chemiluminescent detector is mostly board-like, causes
The sample of sample and the last one detection in the reaction cup of first detection differs more in time, to influence detection essence
Degree.And micropore plate bulk is larger, is not easy to abandon after the completion of detection.And the cup transportation list of existing light-induced chemiluminescent detector
Member need to use multiple delivery devices or multiple mechanical arms to complete transport of glass item between each mechanism, and structure is complicated,
And cost is larger.
Summary of the invention
For the above-mentioned technical problem in the presence of the prior art, the invention proposes a kind of full-automatic light-induced chemiluminescents
Detector, comprising:
Light swashs reading module, for carrying out laser irradiation to sample to be tested and reading；
Cup item transports module, swashs reading module for the cup item for being contained with sample to be tested to be transported to the light；
Wherein, it includes cup transshipment acitivity and cup mounting base, the cup mounting base setting that the cup item, which transports module,
In the two sides of the cup transshipment acitivity, the region that the light swashs reading module is provided with cup mounting base.
In one embodiment, it further includes rack that the cup item, which transports module, and the rack includes substrate and crossbeam；Cup
Mounting base is arranged on the substrate of the crossbeam two sides, and is parallel to each other between cup mounting base；Cup item can be accommodated in institute
It states in cup mounting base.
In one embodiment, the cup transshipment acitivity includes:
First carriage can be slided along the crossbeam, and the bottom of first carriage is equipped with for holding
Set the groove of the cup item；
Second carriage is arranged on first carriage, and second carriage can be along vertical
It is slided in the direction of the crossbeam；
Lifting device is arranged on second carriage, and the lifting device can be connected to the cup when declining
In item, to drive the cup item as the second carriage slides.
In one embodiment, the both ends of the cup item have accommodation groove, and the bottom of the lifting device can abut
In the accommodation groove, to drive the cup item mobile.
In one embodiment, the sharp reading module of the light includes:
Unit is excited, for emitting exciting light；
Detection unit, for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute into
Row acquisition process；
Optical path component, the optical signal for generating after the sample to be tested is excited import the detection unit.
In one embodiment, the sharp reading module of the light includes:
Bottom plate；
Third carriage is arranged on the bottom plate, for driving cup item to slide along first direction；
4th carriage is arranged on the third carriage, for driving cup item to slide in a second direction；
Detection swashs for carrying out light to sample to be tested in optical path testing agency.
In one embodiment, the bottom plate is equipped with cup item and falls slot.
In one embodiment, further include reason cupule, be used to carry out upright arrangement to reaction cup, and reaction cup is sent
Enter reaction cup storehouse mechanism.
In one embodiment, the reason cupule includes leakage cup device and row's cup device, and row's cup device setting exists
The lower section of the leakage cup device, the leakage cup device can make in the controllable row's of the falling into cup device of reaction cup, row's cup
It sets and is arranged for arranging reaction cup.
In one embodiment, the leakage cup device includes:
Cup storehouse, the bottom in the cup storehouse are equipped with leakage rim of a cup；
Combing portion is arranged at the leakage rim of a cup, for combing to the reaction cup at leakage rim of a cup, to control reaction cup
Fall rate.
In one embodiment, the cup storehouse is configured to inverted rectangular pyramid.
In one embodiment, the combing portion includes pedestal and the wheel shaft that is arranged on the pedestal, the wheel shaft
It is equipped with the hairbrush that can extend at the leakage rim of a cup, the wheel shaft is able to drive the hairbrush rotation, to leakage rim of a cup
Reaction cup is combed, and falls rate with control reaction cup.
In one embodiment, row's cup device includes centrifugal mechanism and row cup channel, and the centrifugal mechanism is used for
The centrifugal treating reaction cup that falls into, centrifugal mechanism from the leakage cup device have outlet, through the centrifugal mechanism from
The heart treated reaction cup enters row's cup channel from the outlet, and the inlet in row's cup channel has limiting section,
The limiting section enables reaction cup and enters row cup channel with the posture to lie low, and the row cup channel is for carrying out reaction cup
Upright arrangement.
In one embodiment, full-automatic light-induced chemiluminescent detector further includes incubator, for being chemiluminescence
Immune response provides suitable environment temperature.
In one embodiment, full-automatic light-induced chemiluminescent detector further includes general liquid loading module, and being used for will
General liquid is added to reaction cup.
In one embodiment, the full-automatic light-induced chemiluminescent detector includes that cup item transports module, light swashs reading
Digital-to-analogue block, sample carrier, reason cupule, incubator, sample-adding module, reagent adding module, reagent refrigerating disk, general liquid loading module with
And cup frame is abandoned, the full-automatic light-induced chemiluminescent detector is configured to Dual-layer structure, and the abandoning cup frame is arranged described
Light swashs the lower section of reading module, and the lower section of the reagent adding module, the sample carrier setting is arranged in the reagent refrigerating disk
In the lower section of the sample-adding module, the reason cupule is positioned close to the position that the cup item transports module front end, described general
Liquid loading module is positioned close to the position of the incubator.
Compared with the prior art, the advantages of the present invention are as follows full-automatic light-induced chemiluminescent detectors disclosed by the invention
It uses cup item to transport module to transport the cup item for carrying reaction cup, has abandoned traditional board-like cup item, not only reduced resource
Waste, reduces detection cycle, also enables glass item to be simply and effectively transported to light and swashs reading cell, reduces costs, letter
Structure is changed.
Other features and advantages of the present invention will be illustrated in the following description, also, partial becomes from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention can be by specification, right
Specifically noted structure is achieved and obtained in claim and attached drawing.
Detailed description of the invention
The preferred embodiment of the present invention is described in detail below in conjunction with attached drawing.In figure:
Fig. 1 is a kind of structural schematic diagram of full-automatic light-induced chemiluminescent detector according to the present invention.
Fig. 2 is the structural schematic diagram of the cup transshipment acitivity in Fig. 1.
Fig. 3 is the structural schematic diagram of cup item according to the present invention.
Fig. 4 is the structural schematic diagram one that light according to the present invention swashs reading module.
Fig. 5 is the side view of Fig. 4.
Fig. 6 is the structural schematic diagram of the reception photoswitch in Fig. 4.
Fig. 7 is the structural schematic diagram two that light according to the present invention swashs reading module.
Fig. 8 is the main view that light according to the present invention swashs reading module.
Fig. 9 is the top view that light according to the present invention swashs reading module.
Figure 10 is the structural schematic diagram of reason cupule according to the present invention.
Appended drawing reference: 1- glasss of items transport module；11- rack；111- substrate；112- crossbeam；12- glasss of mounting bases；13- glasss
Item；131- accommodation groove；132- cup aperture；14- glasss of transshipment acitivities；The first carriage of 141-；1411- pedestal；1412- groove；
The second carriage of 142-；143- lifting device；2- light swashs reading module；221- excites unit；222- detection unit；223- light
Road component；224- excitation light switch；2241- rotating part；2242- through-hole；225- receives photoswitch；2251- baffle；2252-
One circular hole；The second circular hole of 2253-；The first rotation section 2254-；The second rotation section 2255-；226- control device；227- half anti-half
Lens；228- lens；229- optical filter；230- opening；21- bottom plate；22- third carriage；The 4th carriage of 23-；24-
Optical path testing agency；25- reaction cup；26- import；201- moves horizontally guide rail；202- vertical shift guide rail；The mobile member of 203-
Part；The first fixing element of 204-；211- transverse shifting guide rail；The vertically movable guide rail of 212-；The second fixing element of 213-；4- manages cup
Device；41- leaks cup device；411- glasss of storehouses；412- combing portion；4121- pedestal；4122- hairbrush；42- arranges cup device；421- centrifuge
Structure；422- arranges cup channel；5- incubator；6- is loaded module；7- reagent adding module；8- reagent refrigerating disk；The general liquid of 9- loads mould
Block；10- abandons cup frame.
In the accompanying drawings, identical component uses identical appended drawing reference.The attached drawing is not drawn according to the actual ratio.
Specific embodiment
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings and examples, how to apply to the present invention whereby
Technological means solves technical problem, and the realization process for reaching technical effect can fully understand and implement.It needs to illustrate
As long as not constituting conflict, each feature in each embodiment and each embodiment in the present invention can be combined with each other,
It is within the scope of the present invention to be formed by technical solution.
Fig. 1 provides a kind of full-automatic light-induced chemiluminescent detector according to the present invention, as shown in Figure 1, this is full-automatic
Light-induced chemiluminescent detector includes that cup item transports module 1 and the sharp reading module 2 of light, and cup item transports module 1 for that will carry
The cup item 13 of reaction cup is transported to light and swashs reading module 2, is contained with sample to be tested in reaction cup, light swash reading module 2 for pair
Sample to be tested carries out laser irradiation and is read.
Full-automatic light-induced chemiluminescent detector disclosed by the invention uses cup item to transport module and carries reaction to transport
The cup item of cup, has abandoned traditional board-like cup item, has not only reduced resource waste, reduce detection cycle, also enables a glass item
The enough light that is simply and effectively transported to swashs reading cell, reduces costs, simplifies structure.
In one embodiment, as depicted in figs. 1 and 2, it includes rack 11, cup mounting base 12, cup item that cup item, which transports module 1,
13 and cup transshipment acitivity 14, rack include substrate 111 and crossbeam 112, cup mounting base 12 is arranged in parallel in 112 two sides of crossbeam
Substrate 111 on, cup item 13 can be accommodated in cup mounting base 12, and cup transshipment acitivity 14 is for transporting cup item.This glass of item
Module 1 is transported by the way of three-dimensional motion, so that glass item is simply and effectively transported to light and swashs reading cell, reduce into
This, simplifies structure.
In one embodiment, as shown in Fig. 2, cup transshipment acitivity 14 includes the first carriage 141, the second carriage
142 and lifting device 143.First carriage 141 can be slided along crossbeam 112, and the pedestal of the first carriage 141
There is the groove 1412 for accommodating cup item 13 on 1411.Second carriage 142 is arranged on the first carriage 141, and
Second carriage 142 can be slided along the direction perpendicular to crossbeam 112.The setting of lifting device 143 is in the second sliding
On device 142, lifting device 143 can be connected in glass item 13 when declining, to drive glass item 13 with the second carriage
142 slidings.Wherein, as shown in figure 3, cup item 13 has the cup aperture 132 of accommodating reaction cup, the quantity of cup aperture 132 can be according to reality
It needs to set, and the both ends of cup item 13 have accommodation groove 131, the movable core of lifting device 143 can be connected to the accommodation groove
In 131, to drive glass item 13 mobile.
Wherein, common sliding-rail sliding formula structure can be used in the first carriage 141 and the second carriage 142, herein
It repeats no more.Lifting device 143 uses common electromagnetic switch, and the movable core of the electromagnetic switch is in vertical direction, and living
Dynamic iron core can be accommodated in the accommodation groove 131 of glass item.
In one embodiment, as shown in figure 4, it includes excitation unit 221, detection unit 222 and optical path that light, which swashs reading module 2,
Component 223.Excitation unit 221 is for emitting exciting light.Detection unit 222 is used to receive to be issued after sample to be tested is excited
Optical signal, and processing is acquired to the received optical signal of institute.What optical path component 223 was used to generate after sample to be tested is excited
Optical signal imports the detection unit.
In one embodiment, excitation unit 221 includes exciter, and the exciter can emit the red of 600~700nm
Exciting light.
In a preferred embodiment, excitation unit 221 further includes excitation light switch 224 other than including exciter, is swashed
Illuminated switch is used to control the conducting and blocking of the exciting light emitted by excitation unit 201.
In one embodiment, as shown in figure 5, excitation light switch 224 includes rotating part 2241, on the side wall of rotating part 2241
There are two through-hole 2242, two through-holes 2242 to pass through the axle center of rotating part 2241 for tool.When the line of two through-holes 2242 is vertical,
Excitation light switch 224 is in the open state, excites light conduction, and exciting light can be irradiated to by through-hole 2242 is located at opening 230
On the sample to be tested of lower section.When the line of two through-holes 2242 is non-vertical, excitation light switch 224 is in close state, excitation
Light is blocked, and exciting light can not be irradiated on the sample to be tested for being located at 230 lower section of opening.
In one embodiment, detection unit 222 include detector, detector be selected from single photon counter, photomultiplier tube,
One of silicon photocell or light-measuring integrating sphere.
In a preferred embodiment, detection unit 222 further includes receiving photoswitch 225, connects other than including detector
Receive conducting or blocking that photoswitch 225 is used to control generated optical signal after sample to be tested is excited.
In one embodiment, as shown in fig. 6, receiving photoswitch 225 includes baffle 2251 and crank and rocker mechanism, baffle
2251 lower part is equipped with the first circular hole 2252；The lower part of crank and rocker mechanism is equipped with the second circular hole 2253, crank and rocker mechanism
Movement enables the first circular hole 2252 and the second circular hole 2253 to overlap, when 2253 phase of the first circular hole 2252 and the second circular hole
It when being mutually overlapped, receives photoswitch 225 and opens, when the first circular hole 2252 and the second circular hole 2253 are not overlapped, receive photoswitch
225 close.
In this embodiment, crank and rocker mechanism includes the first rotation section 2254 and the second rotation section 2255, the first rotation
Portion 2254 is fixed on baffle 2251；Second rotation section 2255 is rotatablely connected the first rotation section 2254, the second circular hole 2253
The lower part of second rotation section 2255 is set.First rotation section 2254 rotates under the drive of the drive, and drives second turn
Dynamic portion 2255 rotates, so that when the second circular hole 2253 turns to the position of corresponding first circular hole 2252, the first circle
Hole 2252 and the second circular hole 2253 overlap.
In one embodiment, as shown in figure 4, excitation light switch 224 and reception photoswitch 225 are all connected with control device 226,
Control device 226 receives photoswitch 225 and closes, and work as and receive photoswitch 225 for making when excitation light switch 224 is connected
When conducting, excitation light switch 224 is closed.Preferably, control device 226 is driver, and one end of the driver connects exciting light
Switch 224, other end connection receives photoswitch 225, when connection, needs so that rotary driver in any case, excitation light switch 224
It all can not be in the open state simultaneously with photoswitch 225 is received.
In one embodiment, as shown in figure 4, optical path component 223 includes half anti-half set gradually along the direction for receiving light
Lens 227, lens 228 and optical filter 229, half-reflecting half mirror 227 are arranged in excitation optical channel and receive the intersection of optical channel.
Half-reflecting half mirror 227 can not only end the exciting light of non-targeted wavelength, while can reflect by the exciting light of target wavelength
The luminous signal of target wavelength caused by sample to be tested.Preferably, half-reflecting half mirror with 45 degree of overturning angles setting exciting lights and
Receive the intersection of light.Enter detection by lens through the optical signal as caused by sample to be tested that half-reflecting half mirror 227 reflects
Unit 222.
In another embodiment, as shown in fig. 7, it includes bottom plate 21, third carriage the 22, the 4th that light, which swashs reading module 2,
Carriage 23 and optical path testing agency 24.Third carriage 22 is arranged on bottom plate 21, for driving cup item 13 along first
Direction is slided, and in the embodiment, first direction is the direction of vertical crossbeams 112, and second direction is to be parallel to the side of crossbeam 112
To.When the first carriage 141, which drives cup item 13 to be moved to along crossbeam 112, swashs reading module 2 by dipped beam, the second sliding dress
It sets 142 promotion cup items and enters transhipment channel via the import 26 that light swashs reading module 2, the 4th sliding at the transhipment channel
Then 23 forward slip of device drives reaction cup 25 to be moved to optical path detection machine to engage glass item 13 by third carriage 22
24 lower section of structure, carries out light to the sample to be tested in reaction cup 25 and swashs reading.In addition, bottom plate 21 is equipped with cup away from the side of import 26
Item falls slot, and after cup item 13 detects, third carriage 22 and the 4th carriage 23 drive cup article 13 to be moved to cup
After item falls the position of slot, the 4th carriage 23 unclamps cup article 13, and cup item 13 is fallen from slot is fallen.
Preferably, as shown in figure 8, light swashs reading module 2 it is so structured that such as flowering structure: including moving horizontally guide rail 201
With vertical shift guide rail 202, moves horizontally guide rail 201 and vertical shift guide rail 202 constitutes a closed circuit.In the present embodiment
Move horizontally guide rail 201 include about two two to be parallel to each other move horizontally guide rail, the horizontal movement of moving element 203
Underface of the track Jing Guo optical path detection probe, is examined so that reaction cup can be moved to immediately below optical path testing agency
It surveys.Wherein, moving element 203 has the unit of fixed cup item, specifically can be set to inserted sheet, or be set as claw etc..
Vertical shift guide rail 202 in the present embodiment includes the vertical shift guide rail of left and right two being parallel to each other.It is vertical to move
Dynamic guide rail 202 is for driving moving element 203 to move up and down.It is solid that first is respectively arranged on two vertical shift guide rails 202
Determine element 204, the first fixing element 204 is for fixing moving element 203 and driving moving element 203 along vertical shift guide rail
202 move up and down.It is provided with sensor in first fixing element 204, when moving element 203 is completely into the first fixing element
When 204, sensor issues signal, and detector starts lifting action, and moving element 203 is driven to move up and down.
Specifically, light is carried out when cup item is moved to the underface of optical path detection probe under the drive of moving element 203 to swash
Detection, the cup item after detection continue to move horizontally under the drive of moving element 203, far from optical path testing agency until vertical move
When at dynamic guide rail 202, the first fixing element 204 drives moving element to drop at B, and carries out abandoning cup movement at B, abandons cup
Afterwards, moving element 203 is detached from the first fixing element 204, and edge moves horizontally the vertical shift guide rail C that guide rail is moved to the other side
Place, when moving element 203 is completely into the first fixing element 204 on the vertical shift guide rail 202, the first fixing element
Sensor on 204 issues signal, detector starting operation, and moving element rises to the water on upper layer along vertical shift guide rail 202
At flat moving guide rail A, and next group secondary cup item is driven to repeat above-mentioned movement at A.Can be in the moving element of operation simultaneously
It is multiple, as long as guarantee that light swashs reading, (light leakage can not be avoided to impact reading) in sample introduction at A mouthfuls.
In another preferred embodiment, as shown in figure 9, light swashs reading module 2 it is so structured that such as flowering structure: including
Two transverse shifting guide rails 211 being parallel to each other and two vertically movable guide rails 212 being parallel to each other, transverse shifting guide rail 211
The closed circuit for being parallel to horizontal plane is constituted with vertically movable guide rail 212.
The underface of optical path detection probe is arranged in one of transverse shifting guide rail 211, so that cup item can be moved to
It is detected the underface of optical path testing agency 24.Wherein, moving element has the unit of fixed cup item, specifically can be set to
Inserted sheet, or be set as claw etc..
The second fixing element 213 is respectively arranged on this two vertically movable guide rails 212, the second fixing element 213 is used for
Fixed moving element 203 simultaneously drives the vertically movement of moving guide rail 212 of moving element 203.It is provided in second fixing element 213
Sensor, when moving element 203 is completely into the second fixing element 213, sensor sending signal, detector starting operation,
Drive moving element vertically movable.
Specifically, referring to Fig. 9, when cup item is moved to the underface of optical path detection probe under the drive of moving element 203
It carries out light and swashs detection, the cup item after detection continues transverse shifting under the drive of moving element, straight far from optical path testing agency 24
When to vertically movable guide rail 212, moving element enters the second fixing element 213, and the second fixing element 213 drives moving element
203 are moved at D, carry out abandoning cup movement at D, after abandoning cup, moving element 203 is detached from the second fixing element 213, and laterally moves
Next group secondary cup item is driven to repeat above-mentioned movement when moving to E.Simultaneously the moving element of operation can be to be multiple, as long as guaranteeing
When light swashs reading, (light leakage can not be avoided to impact reading) in sample introduction at E mouthfuls.
In one embodiment, as shown in Figure 10, full-automatic light-induced chemiluminescent detector further includes reason cupule 4, is used for
Upright arrangement is carried out to reaction cup.
In one embodiment, reason cupule 4 includes leakage cup device 41 and row's cup device 42, and the setting of row's cup device 42 is in leakage cup
41 lower section is set, leakage cup device 41 can make in the controllable row's of the falling into cup device 42 of reaction cup, and row's cup device 42 is used for will be anti-
Cup is answered to carry out upright arrangement.
In one embodiment, leakage cup device 41 includes cup storehouse 411 and combing portion 412.The bottom in cup storehouse 411 is equipped with leakage cup
Mouthful, the setting of combing portion 412 combs the reaction cup being located at the leakage rim of a cup, at leakage rim of a cup to control falling for reaction cup
Terminal-velocity rate.Preferably, cup storehouse 411 is configured to inverted rectangular pyramid, and upper opening area is big, and it is small to leak opening area at rim of a cup.
In one embodiment, combing portion 412 includes pedestal 4121 and the wheel shaft being arranged on pedestal 4121, is arranged on wheel shaft
There is the hairbrush 4122 that can extend at leakage rim of a cup, wheel shaft is able to drive the rotation of hairbrush 4122, so that reaction cup is in hairbrush
The controllable row's of falling into cup device 42 under combing.In the embodiment as shown in fig.5, combing portion 412 has two wheel shafts, hairbrush
4122 are mounted on two wheel shafts, and rotate the rotation direction of two wheel shafts inwards, so that being set in this
Hairbrush on two wheel shafts is inwards rotated to cooperate combing reaction cup.
Row's cup device 42 includes centrifugal mechanism 421 and row cup channel 422 in one embodiment.It is fallen from leakage cup device 41
Centrifugal treating of the reaction cup through centrifugal mechanism 421 so that reaction cup disperse, without being deposited in a place.Centrifugal mechanism
421 have outlet, and the opening width of outlet is not more than the length of a reaction cup, so that reaction cup can be slided from there
Out.Enter row cup channel 422 through the reaction cup that outlet skids off, the inlet in row cup channel 422 has limiting section, and limiting section makes
Reaction cup is obtained to be merely able to enter row cup channel 422 with the posture to lie low.Three transmission being set side by side are equipped in row cup channel 422
The length of band, an intermediate conveyer belt is short, and the width of an intermediate conveyer belt is greater than the width of cup body and is less than the width of cup head,
Two conveyer belts of the position and two sides that terminate to middle carousel constitute row's cup groove, and the reaction cup to lie low is by row cup
It when groove location, is arranged again with upright posture, and reaction cup is finally delivered to the end in row cup channel with upright posture.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes incubator 5, for being to change
It learns electrochemiluminescent immunoassay reaction and suitable environment temperature is provided.In this embodiment, one that cup item transports module 1 is arranged in incubator 5
Side, and 13 mounting base 12 of cup item for cup placement item is equipped in incubator 5.After having prepared sample to be tested, cup item transports module 1
It will be incubated in cup mounting base 12 that cup item is transported in incubator 5.
Preferably, incubator 5 includes that the first incubation unit and second incubate unit.Unit movement is incubated from first in cup item
During incubating unit to second, general liquid is added in the reaction cup in the cup item by general liquid loading module.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes sample-adding module 6, in the reality
It applies in example, sample-adding module 6 is positioned close to the front end that glass item transports module 1.Cup item transports the cup that module 1 will carry reaction cup
Item is transported to the addition that sample-adding module 6 carries out sample first.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes reagent adding module 7, at this
In embodiment, reagent adding module 7 is positioned close to the position of sample-adding module 6.The cup item for having added sample transports module 1 in cup item
Drive under be detached from sample-adding module 6, and be moved to reagent adding module 7 carry out reaction reagent addition.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes reagent refrigerating disk 8, reagent
Reaction reagent is held in refrigeration disk.In the embodiment, the lower section of reagent adding module 7 is arranged in reagent refrigerating disk, to facilitate machinery
Sample arm is drawn reagent from reagent refrigerating disk 8 and is added in glass item.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes general liquid loading module 9.
In this embodiment, general liquid loading module 9 is positioned close to the position of incubator 5, when cup item incubates unit movement from first
General liquid is added during incubating unit to second.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector further includes abandoning cup frame 10, in the reality
It applies in example, abandons cup frame 10 and the lower section that light swashs reading module 2 is set, swash the cup item abandoned after reading for holding light.
In one embodiment, as shown in Figure 1, full-automatic light-induced chemiluminescent detector includes that cup item transports module 1, light swashs
Read module 2, sample carrier (not shown), reason cupule 4, incubator 5, sample-adding module 6, reagent adding module 7, reagent refrigerating
Disk 8, general liquid loading module 9 and abandoning cup frame 10.In the embodiment, detector is configured to Dual-layer structure, abandons cup frame 10
The lower section that light swashs reading module 2 is set, and the lower section of reagent adding module 7 is arranged in reagent refrigerating disk 8, and the setting of sample carrier is adding
The lower section of egf block 6, reason cupule 4 are positioned close to the position that glass item transports 1 front end of module, and the general setting of liquid loading module 9 exists
In the position of incubator 5, superstructure, the two sides that cup item transports module 1 are arranged in modules, with convenient cup item each
Transport between a module.This kind of Dual-layer design, can shorten instrument size, so that the cooperation between each component more steps up
Close smoothness, to further increase detection efficiency.
The foregoing is merely the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, Ren Heben
The technical staff in field can be easy to carry out and be altered or varied in technical scope disclosed by the invention, and this change or change
Change should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (16)
1. a kind of full-automatic light-induced chemiluminescent detector characterized by comprising
Light swashs reading module, for carrying out laser irradiation to sample to be tested and reading；
Cup item transports module, swashs reading module for the cup item for being contained with sample to be tested to be transported to the light；
Wherein, it includes cup transshipment acitivity and cup mounting base that the cup item, which transports module, and the cup mounting base is arranged in institute
The two sides of cup transshipment acitivity are stated, the region that the light swashs reading module is provided with cup mounting base.
2. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that the cup item transports module
It further include rack, the rack includes substrate and crossbeam；Cup mounting base is arranged on the substrate of the crossbeam two sides, and cup item
It is parallel to each other between mounting base；Cup item can be accommodated in the cup mounting base.
3. full-automatic light-induced chemiluminescent detector according to claim 2, which is characterized in that the cup transshipment acitivity
Include:
First carriage can be slided along the crossbeam, and the bottom of first carriage is equipped with for accommodating
State the groove of glass item；
Second carriage is arranged on first carriage, and second carriage can be along perpendicular to described
It slides in the direction of crossbeam；
Lifting device is arranged on second carriage, and the lifting device can be connected in the cup item when declining,
To drive the cup item as the second carriage slides.
4. full-automatic light-induced chemiluminescent detector according to claim 3, which is characterized in that the both ends of the cup item have
There is accommodation groove, the bottom of the lifting device can be connected in the accommodation groove, to drive the cup item mobile.
5. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that the light swashs reading module
Include:
Unit is excited, for emitting exciting light；
Detection unit is adopted for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute
Collection processing；
Optical path component, the optical signal for generating after the sample to be tested is excited import the detection unit.
6. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that the light swashs reading module
Include:
Bottom plate；
Third carriage is arranged on the bottom plate, for driving cup item to slide along first direction；
4th carriage is arranged on the third carriage, for driving cup item to slide in a second direction；
Detection swashs for carrying out light to sample to be tested in optical path testing agency.
7. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that the bottom plate is equipped with cup
Item falls slot.
8. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that it further include reason cupule,
For carrying out upright arrangement to reaction cup.
9. full-automatic light-induced chemiluminescent detector according to claim 8, which is characterized in that the reason cupule includes leakage
The lower section of the leakage cup device is arranged in cup device and row's cup device, row's cup device, and the leakage cup device can make to react
In the controllable row's of the falling into cup device of cup, row's cup device is used to reaction cup carrying out arrangement arrangement.
10. full-automatic light-induced chemiluminescent detector according to claim 9, which is characterized in that the leakage cup device packet
It includes:
Cup storehouse, the bottom in the cup storehouse are equipped with leakage rim of a cup；
Combing portion is arranged at the leakage rim of a cup, for combing to the reaction cup at leakage rim of a cup, to control falling for reaction cup
Terminal-velocity rate.
11. full-automatic light-induced chemiluminescent detector according to claim 10, which is characterized in that the cup storehouse is configured to
Inverted rectangular pyramid.
12. full-automatic light-induced chemiluminescent detector according to claim 10, which is characterized in that the combing portion includes
Pedestal and the wheel shaft being arranged on the pedestal, the wheel shaft are equipped with the hairbrush that can extend at the leakage rim of a cup, the wheel
Axis is able to drive hairbrush rotation, to comb to the reaction cup at leakage rim of a cup, falls rate with control reaction cup.
13. full-automatic light-induced chemiluminescent detector according to claim 9, which is characterized in that row's cup device packet
Include centrifugal mechanism and row cup channel, the reaction cup that the centrifugal mechanism is fallen into from the leakage cup device for centrifugal treating, institute
Centrifugal mechanism is stated with outlet, the reaction cup after the centrifugal mechanism centrifugal treating enters row's cup from the outlet
Channel, the inlet in row's cup channel have limiting section, and the limiting section is enabled reaction cup and entered with the posture to lie low
Cup channel is arranged, row's cup channel is used to reaction cup carrying out upright arrangement.
14. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that further include incubator, use
Suitable environment temperature is provided in reacting for chemiluminescence immunoassay.
15. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that further include that general liquid adds
Module is carried, for general liquid to be added to reaction cup.
16. full-automatic light-induced chemiluminescent detector according to claim 1, which is characterized in that the full-automatic light swashs
Chemiluminescence detector include cup item transport module, light swash reading module, sample carrier, reason cupule, incubator, sample-adding module,
Reagent adding module, reagent refrigerating disk, general liquid loading module and abandoning cup frame, the full-automatic light-induced chemiluminescent detector structure
It makes as Dual-layer structure, the lower section that the light swashs reading module is arranged in the cup frame of abandoning, and the reagent refrigerating disk setting exists
The lower section of the sample-adding module is arranged in the lower section of the reagent adding module, the sample carrier, and the reason cupule setting is being leaned on
The nearly cup item transports the position of module front end, and the general liquid loading module is positioned close to the position of the incubator.
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| CN201810400851.3A CN110412258A (en) | 2018-04-28 | 2018-04-28 | Full-automatic light-induced chemiluminescent detector |
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| CN201810400851.3A CN110412258A (en) | 2018-04-28 | 2018-04-28 | Full-automatic light-induced chemiluminescent detector |
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