CN110412019A - A kind of detection device and full-automatic light-induced chemiluminescent detector - Google Patents
A kind of detection device and full-automatic light-induced chemiluminescent detector Download PDFInfo
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- CN110412019A CN110412019A CN201810398599.7A CN201810398599A CN110412019A CN 110412019 A CN110412019 A CN 110412019A CN 201810398599 A CN201810398599 A CN 201810398599A CN 110412019 A CN110412019 A CN 110412019A
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- 238000001514 detection method Methods 0.000 title claims abstract description 56
- 239000011521 glass Substances 0.000 claims abstract description 10
- 230000005284 excitation Effects 0.000 claims description 41
- 230000003287 optical effect Effects 0.000 claims description 22
- 230000003028 elevating effect Effects 0.000 claims description 7
- 230000000903 blocking effect Effects 0.000 claims description 6
- 230000008676 import Effects 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000008450 motivation Effects 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 238000011534 incubation Methods 0.000 abstract description 3
- 230000007246 mechanism Effects 0.000 description 10
- 230000033001 locomotion Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000001360 synchronised effect Effects 0.000 description 6
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- 230000003321 amplification Effects 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
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- 102000004190 Enzymes Human genes 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Abstract
The invention discloses a kind of detection devices, including light swashs reading module and cup item hooks up pushing module.Light, which swashs reading module, to be used to carry out laser irradiation to the sample to be tested after incubation and records transmitting light quantity, and cup item hooks up pushing module and swashs reading module for the cup item for being contained with sample to be tested to be transported to light.Wherein, it includes hooking up unit and push unit that cup item, which hooks up pushing module, hooks up unit and is arranged on push unit, and after hooking up unit and hooking up glass item, cup item is pushed to light and swashs reading module by push unit to be read.Detection device disclosed by the invention hooks up pushing module by the way that the cup item for swashing reading module cooperation with light is arranged, and improves the degree of automation of detection device, shortens detection cycle, has saved cost.
Description
Technical field
The present invention relates to chemiluminescence immunoassay technology fields, swash more particularly, to a kind of detection device and full-automatic light
Chemiluminescence detector.
Background technique
Immunology detection be based on antigen and antibody specific reaction principle carry out, due to its can use isotope,
Enzyme, chemiluminescent substance etc. carry out display or the amplification of signal to measured object, therefore are commonly used for detecting protein, hormone etc. micro-
Measure bioactive substance.
Chemiluminescence immune assay is then to develop relatively rapid on-radiation immunoassay technology in recent years, and principle is benefit
The amplification of signal is carried out with chemiluminescent substance, and by its luminous intensity, immune cohesive process is directly measured, the method
Have become one of the important directions of immunology detection.
It is to be sent reaction cup item by mobile mechanism after the completion of sample to be tested incubates in existing light-induced chemiluminescent detection
Enter reading cell, or the sample to be tested after incubation is sent by reading cell by artificial sample introduction.But the two methods are deposited
In certain problem, artificial sample introduction efficiency is low and has the possibility of pollution sample, and mobile mechanism needs additional mechanical gripper to match more
Conjunction could complete transmission of the reaction cup between reading cell and incubator, the cooperation between detector reading cell and incubator
Degree is low, low efficiency.
And lath used is mostly board-like in the detection device of existing light-induced chemiluminescent detector, leads to first detection
The sample of sample and the last one detection in reaction cup differs more in time, to influence detection accuracy.And microwell plate
Volume is larger, is not easy to abandon after the completion of detection.
Summary of the invention
For the above-mentioned technical problem in the presence of the prior art, the invention proposes a kind of detection device and full-automatic light
Swash chemiluminescence detector.
According to an aspect of the present invention, a kind of detection device is provided, comprising:
Light swashs reading module, for carrying out laser irradiation to sample to be tested and reading；
Cup item hooks up pushing module, swashs reading module for the cup item for being contained with sample to be tested to be transported to the light；
Wherein, it includes hooking up unit and push unit that the cup item, which hooks up pushing module, and the unit that hooks up is arranged in institute
State on push unit, when it is described hook up unit and hook up glass item after, cup item is pushed to the light and swashs reading mould by the push unit
Block carries out light and swashs reading.
In one embodiment, the push unit includes:
Bottom plate；
First sliding equipment is arranged on the bottom plate, and first sliding equipment can slide along a first direction,
The groove for accommodating cup item is provided on first sliding equipment；
Second sliding equipment is arranged on first sliding equipment, and second sliding equipment can be along second
Direction sliding.
In one embodiment, the unit that hooks up includes the lifting device being arranged on second sliding equipment,
There is the elevating lever that can be accommodated in the pick-up hole of glass item on the lifting device.
In one embodiment, first sliding equipment include sliding rail and can along the sliding rail slide sliding block,
The groove and second sliding equipment are respectively provided on the slide block, and the glide direction of second sliding equipment is parallel
In the groove, the surface of the groove is arranged in the elevating lever.
In one embodiment, the sharp reading module of the light includes:
Unit is excited, for emitting exciting light；
Detection unit, for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute into
Row acquisition process；
Optical path component, the optical signal for generating after the sample to be tested is excited import the detection unit.
In one embodiment, the excitation unit includes exciter, and the exciter can emit 600~700nm
Red exciting light.
In one embodiment, the excitation unit further includes excitation light switch, and the excitation light switch is for controlling
By the conducting and blocking of the exciting light of the excitation unit transmitting.
In one embodiment, the detection unit includes detector, and the detector is selected from single photon counter, light
Electric multiplier tube, silicon photocell or light-measuring integrating sphere.
In one embodiment, the detection unit further includes receiving photoswitch, and the reception photoswitch is for controlling
The conducting or blocking of the sample to be tested generated optical signal after being excited.
In one embodiment, the excitation light switch and the reception photoswitch are all connected with control device, the control
Device processed for making when the excitation light switch is connected, close by the reception photoswitch, and when the reception photoswitch is led
When logical, the excitation light switch is closed.
According to another aspect of the present invention, a kind of full-automatic light-induced chemiluminescent detector is provided, including the inspection
Survey device.
Compared with the prior art, the advantages of the present invention are as follows detection device disclosed by the invention, which is swashed by setting with light, to be read
The cup item of digital-to-analogue block cooperation hooks up pushing module, so that the sample introduction that light swashs reading module is more smooth close, improves detection dress
The degree of automation set, and cup item of the present invention, have abandoned traditional strip type, have saved cost, shortened inspection
Survey the period.
Other features and advantages of the present invention will be illustrated in the following description, also, partial becomes from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention can be by specification, right
Specifically noted structure is achieved and obtained in claim and attached drawing.
Detailed description of the invention
The preferred embodiment of the present invention is described in detail below in conjunction with attached drawing.In figure:
Fig. 1 is a kind of structural schematic diagram of detection device according to the present invention.
Fig. 2 is the structural schematic diagram that cup item in Fig. 1 hooks up pushing module.
Fig. 3 is the structural schematic diagram of the cup item in Fig. 2.
Fig. 4 is the structural schematic diagram that light according to the present invention swashs reading module.
Fig. 5 is the side view that light according to the present invention swashs reading module.
Fig. 6 is the structural schematic diagram of the reception photoswitch in Fig. 4.
Fig. 7 is the structural schematic diagram for the sample presentation unit that light according to the present invention swashs reading module.
Fig. 8 is the main view that light according to the present invention swashs reading module.
Fig. 9 is the top view that light according to the present invention swashs reading module.
Appended drawing reference: 1- light swashs reading module；11- excites unit；12- detection unit；13- optical path component；131- half is anti-
Pellicle mirror；132- lens；133- optical filter；14- control device；141- pedestal；142- third sliding equipment；143- the 4th is slided
Mechanism；144- is inserted and is taken plate；145- glasss of items fall slot；15- opening；121- receives photoswitch；122- excitation light switch；111- rotation
Portion；112- through-hole；1211- baffle；The first circular hole of 1212-；The second circular hole of 1213-；The first rotation section 1214-；Second turn of 1215-
Dynamic portion；2- glasss of items hook up pushing module；221- bottom plate；The first sliding equipment of 222-；The second sliding equipment of 223-；225-L shape branch
Frame；The first sliding rail of 2221-；The first belt pulley of 2222-；2223- first motor；The first synchronous belt of 2224-；2225- transfer plate；
2226- groove；The second sliding rail of 2231-；2232- sliding block；The second synchronous belt of 2233-；The second belt pulley of 2234-；2235- tensioning
Wheel；2236- second base；2237- lifting device；2238 elevating levers；3- glasss of items；31- pick-up hole；32- cup aperture；201- level is moved
Dynamic guide rail；202- vertical shift guide rail；203- moving element；The first fixing element of 204-；211- transverse shifting guide rail；212- is perpendicular
To moving guide rail；The second fixing element of 213-.
In the accompanying drawings, identical component uses identical appended drawing reference.The attached drawing is not drawn according to the actual ratio.
Specific embodiment
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings and examples, how to apply to the present invention whereby
Technological means solves technical problem, and the realization process for reaching technical effect can fully understand and implement.It needs to illustrate
As long as not constituting conflict, each feature in each embodiment and each embodiment in the present invention can be combined with each other,
It is within the scope of the present invention to be formed by technical solution.
Fig. 1 provides a kind of detection device, including light swashs reading module 1 and cup item hooks up pushing module 2.Light swashs reading mould
Block 1 is used to carry out laser irradiation to the sample to be tested after incubation and read；Cup item hooks up pushing module 2 for that will be contained with
The cup item of sample to be tested is transported to light and swashs reading module 1.
Wherein, it includes hooking up unit and push unit that cup item, which hooks up pushing module 2, hooks up unit and is arranged in push unit
On, after hooking up unit and hooking up glass item, cup item is pushed to light and swashs reading module 1 and carry out light by push unit swashs reading.
Detection device disclosed by the invention hooks up pushing module by the way that the cup item for swashing reading module cooperation with light is arranged, so that
The sample introduction that light swashs reading module is more smooth close, improves the degree of automation of detection device, and of the present invention
Cup item, has abandoned traditional strip type, has saved cost, shortened detection cycle.
In one embodiment, as shown in Fig. 2, push unit includes bottom plate 221, the first sliding equipment 222 and the second sliding
Mechanism 223.First sliding equipment 222 is arranged on bottom plate 221, and the first sliding equipment 222 can slide along a first direction,
The groove 2226 for accommodating cup item is provided on first sliding equipment 222.Second sliding equipment 223 is arranged in the first skate machine
On structure 222, and the second sliding equipment 223 can be slided along second direction.In this embodiment, first direction is X-direction, the
Two directions are Y-direction.
In one embodiment, as shown in Fig. 2, the first sliding equipment 222 includes the first sliding rail 2221, close to the first sliding rail
2221 both ends are respectively equipped with the first belt pulley 2222, one of them first belt pulley connection first motor 2223, and two first
The first synchronous belt 2224 is set between belt pulley 2222, which is parallel to each other with the first sliding rail 2221, the
One synchronous belt 2224 is equipped with synchronization blocks (not shown), and transfer plate 2225 is connect with synchronization blocks.Transfer plate 2225 is equipped with
Accommodate the groove 2226 of cup item.
In this embodiment, the second sliding equipment 223 is arranged on transfer plate 2225 by L bracket 225.Second sliding
Mechanism 223 includes the second sliding rail 2231 and can be parallel to along the sliding block 2232 of the second sliding rail 2231 sliding, the second sliding rail 2231
Groove 2226.Second sliding equipment 223 further includes the second synchronous belt 2233, second for driving sliding block 2232 to slide along Y-direction
Motor (not shown), the second belt pulley 2234 and at least one tensioning wheel 2235.Tensioning wheel 2235, the second synchronous belt 2233
It is arranged in second base 2236 with the second belt pulley 2234.
In one embodiment, as shown in Fig. 2, hooking up unit includes the lifting device being arranged on the second sliding equipment 223
2237, there is on lifting device 2237 elevating lever 2238 that can be accommodated in the pick-up hole 31 of glass item 3.
In one embodiment, as shown in figure 3, cup item 3 has the cup aperture 32 of accommodating reaction cup, the quantity of cup aperture 32 can basis
The both ends of actual needs setting, cup item 3 have pick-up hole 31, and elevating lever 2238 can be connected in the pick-up hole 31, thus band
Dynamic cup item 3 is mobile.
In one embodiment, as shown in figure 4, it includes excitation unit 11, detection unit 12 and optical path group that light, which swashs reading module 1,
Part 13.Excitation unit 11 is for emitting exciting light.Detection unit 12 is used to receive the light letter issued after sample to be tested is excited
Number, and processing is acquired to the received optical signal of institute.The light letter that optical path component 13 is used to generate after sample to be tested is excited
Number import the detection unit.
In one embodiment, excitation unit 11 includes exciter, and the exciter can emit the red of 600~700nm
Exciting light.
In a preferred embodiment, excitation unit 11 further includes excitation light switch 122 other than including exciter, is swashed
Illuminated switch 122 is used to control the conducting and blocking of the exciting light emitted by excitation unit 11.
In one embodiment, as shown in figure 5, excitation light switch 122 includes rotating part 111, have on the side wall of rotating part 111
There are two through-hole 112, two through-holes 112 pass through the axle center of rotating part.When the line of two through-holes 112 is vertical, exciting light is opened
In the open state, excitation light conduction is closed, exciting light can be irradiated to the sample to be tested for being located at 15 lower sections that are open by through-hole 112
On.When the line of two through-holes 112 is non-vertical, excitation light switch is in close state, and exciting light is blocked, and exciting light can not
It is irradiated on the sample to be tested for being located at 15 lower section of opening.
In one embodiment, detection unit 12 include detector, detector be selected from single photon counter, photomultiplier tube,
One of silicon photocell or light-measuring integrating sphere.
In a preferred embodiment, detection unit 12 further includes receiving photoswitch 121, connects other than including detector
Receive conducting or blocking that photoswitch 121 is used to control generated optical signal after sample to be tested is excited.
In one embodiment, as shown in fig. 6, receiving photoswitch 121 includes baffle 1211 and crank and rocker mechanism, baffle
1211 lower part is equipped with the first circular hole 1212；The lower part of crank and rocker mechanism is equipped with the second circular hole 1213, crank and rocker mechanism
Movement enables the first circular hole 1212 and the second circular hole 1213 to overlap, when 1213 phase of the first circular hole 1212 and the second circular hole
It when being mutually overlapped, receives photoswitch 121 and opens, when the first circular hole 1212 and the second circular hole 1213 are not overlapped, receive photoswitch
121 close.
In this embodiment, crank and rocker mechanism includes the first rotation section 1214 and the second rotation section 1215, the first rotation
Portion 1214 is fixed on baffle 1211；Second rotation section 1215 is rotatablely connected the first rotation section 1214, the second circular hole 1213
The lower part of second rotation section 1215 is set.First rotation section 1214 rotates under the drive of the drive, and drives second turn
Dynamic portion 1215 rotates, so that when the second circular hole 1213 turns to the position of corresponding first circular hole 1212, the first circle
Hole 1212 and the second circular hole 1213 overlap.
In one embodiment, as shown in figure 4, excitation light switch 122 and reception photoswitch 121 are all connected with control device 14,
Control device 14 receives photoswitch 121 and closes for making when excitation light switch 122 is connected, and leads when receiving photoswitch 121
When logical, excitation light switch 122 is closed.Preferably, control device 14 is driver, and one end of the driver connects excitation light switch
122, other end connection receives photoswitch 121, when connection, needs so that rotary driver in any case, excitation light switch 122 and connects
Receiving photoswitch 121 all can not be in the open state simultaneously.
In one embodiment, as shown in figure 4, optical path component 13 includes the half-reflection and half-transmission set gradually along the direction for receiving light
Mirror 131, lens 132 and optical filter 133, half-reflecting half mirror 131 are arranged in excitation optical channel and receive the intersection of optical channel.Half
Anti- pellicle mirror 131 can not only end the exciting light of non-targeted wavelength by the exciting light of target wavelength, at the same can reflect to
The luminous signal of target wavelength caused by sample.Preferably, half-reflecting half mirror 131 with 45 degree of overturning angles setting exciting lights and
Receive the intersection of light.The optical signal as caused by sample to be tested reflected through half-reflecting half mirror 131 enters inspection by lens 132
Survey unit 12.
In an embodiment preferably, light swashs reading module 1 in addition to including excitation unit 11, detection unit 12 and optical path
It further include sample presentation unit outside component 13.Sample presentation unit is used to for sample to be tested being transferred to the underface of excitation unit 11.
In one embodiment, as shown in fig. 7, sample presentation unit includes pedestal 141, the third being arranged on pedestal 141 sliding
Mechanism 142 and the 4th sliding equipment 143 being arranged on third sliding equipment 142.Third sliding equipment 142 and the 4th is slided
The glide direction of motivation structure 143 is mutually perpendicular to, and in this embodiment, the glide direction of third sliding equipment 142 is Y-direction, and the 4th
The glide direction of sliding equipment 143 be X to.When cup item hooks up the second sliding equipment 223 in delivery device 2 along Y-direction for cup item 3
After being pushed into the import that light swashs reading module 1, the 4th sliding equipment 143 from being located at the entrance, which drives to insert, takes plate 144 to advancing slip
It is dynamic to take glass item 3 to insert, inspection is then swashed by the underface progress light that third sliding equipment 142 drives cup item 3 to be moved to opening 15 again
It surveys.After light swashs detection, then is driven by the 4th sliding equipment 143 to insert to take plate 144 forward or be moved rearwardly into glass and article be fallen
Behind the position of slot 145, inserts and plate 144 is taken to put a glass item aside, cup item falls slot 145 from cup item and falls.Wherein, third sliding equipment 142
Specific structure with the 4th sliding equipment 143 can be identical as above-mentioned first sliding equipment 222 and the second sliding equipment 223, this
Place repeats no more.
In a preferred embodiment, sample presentation unit can also be arranged to such as flowering structure, as shown in Figure 8: move including level
Dynamic guide rail 201 and vertical shift guide rail 202, move horizontally guide rail 201 and vertical shift guide rail 202 constitutes a closed circuit.
The guide rail 201 that moves horizontally in the present embodiment includes that two to be parallel to each other up and down move horizontally guide rail, the water of moving element 203
Flat motion profile excites the underface of unit 11 to be examined by the underface of excitation unit 11 so that cup item can be moved to
It surveys.Wherein, moving element 203 has the unit of fixed cup item, specifically can be set to inserted sheet, or be set as claw etc..
Vertical shift guide rail 202 in the present embodiment includes the vertical shift guide rail of left and right two being parallel to each other.It is vertical to move
Dynamic guide rail 202 is for driving moving element 203 to move up and down.It is solid that first is respectively arranged on two vertical shift guide rails 202
Determine element 204, the first fixing element 204 is for fixing moving element 203 and driving moving element 203 along vertical shift guide rail
202 move up and down.It is provided with sensor in first fixing element 204, when moving element 203 is completely into the first fixing element
When 204, sensor issues signal, and detector starts lifting action, and moving element 203 is driven to move up and down.
Specifically, light, which is carried out, when cup item is moved to the underface of excitation unit under the drive of moving element 203 swashs detection,
Cup item after detection continues to move horizontally under the drive of moving element 203, far from excitation unit 11 until vertical shift guide rail
When at 202, the first fixing element 204 drives moving element to drop at B, and carries out abandoning cup movement at B, mobile after abandoning cup
Element 203 is detached from the first fixing element 204, and is moved at the vertical shift guide rail C of the other side along guide rail is moved horizontally, and works as shifting
Biography when dynamic element 203 is completely into the first fixing element 204 on the vertical shift guide rail 202, in the first fixing element 204
Sensor issues signal, detector starting operation, and moving element moves horizontally guide rail along what vertical shift guide rail 202 rose to upper layer
At A, and next group secondary cup item is driven to repeat above-mentioned movement at A.Simultaneously the moving element of operation can be to be multiple, as long as protecting
When card light swashs reading, (light leakage can not be avoided to impact reading) in sample introduction at A mouthfuls.
In another preferred embodiment, as shown in figure 9, light swashs reading module 2 it is so structured that such as flowering structure: including
Two transverse shifting guide rails 211 being parallel to each other and two vertically movable guide rails 212 being parallel to each other, transverse shifting guide rail 211
The closed circuit for being parallel to horizontal plane is constituted with vertically movable guide rail 212.
One of transverse shifting guide rail 211 be arranged in excitation unit 11 underface so that cup item can be moved to it is sharp
It is detected the underface of bill member 11.Wherein, moving element has the unit of fixed cup item, specifically can be set to inserted sheet,
Or be set as claw etc..
The second fixing element 213 is respectively arranged on this two vertically movable guide rails 212, the second fixing element 213 is used for
Fixed moving element 203 simultaneously drives the vertically movement of moving guide rail 212 of moving element 203.It is provided in second fixing element 213
Sensor, when moving element 203 is completely into the second fixing element 213, sensor sending signal, detector starting operation,
Drive moving element vertically movable.
Specifically, referring to Fig. 9, cup item be moved under the drive of moving element 203 excitation unit 11 underface when into
Row light swashs detection, and the cup item after detection continues transverse shifting under the drive of moving element, far from excitation unit 11 until vertical
When at moving guide rail 212, moving element enters the second fixing element 213, and the second fixing element 213 drives moving element 203 to move
It moves to D, carries out abandoning cup movement at D, after abandoning cup, moving element 203 is detached from the second fixing element 213, and laterally moves to E
Next group secondary cup item is driven to repeat above-mentioned movement when place.It can be simultaneously multiple in the moving element of operation, as long as guaranteeing that light swashs
When reading, (light leakage can not be avoided to impact reading) in sample introduction at E mouthfuls.
According to another aspect of the present invention, a kind of full-automatic light-induced chemiluminescent detector is provided, including above-mentioned inspection
Survey device.
The foregoing is merely the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, Ren Heben
The technical staff in field can be easy to carry out and be altered or varied in technical scope disclosed by the invention, and this change or change
Change should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (11)
1. a kind of detection device characterized by comprising
Light swashs reading module, for carrying out laser irradiation to sample to be tested and reading；
Cup item hooks up pushing module, swashs reading module for the cup item for being contained with sample to be tested to be transported to the light；
Wherein, it includes hooking up unit and push unit that the cup item, which hooks up pushing module, described to hook up unit setting and push away described
Send on unit, when it is described hook up unit and hook up glass item after, the push unit by cup item push to the light swash reading module into
Row light swashs reading.
2. detection device according to claim 1, which is characterized in that the push unit includes:
Bottom plate；
First sliding equipment is arranged on the bottom plate, and first sliding equipment can slide along a first direction, described
The groove for accommodating cup item is provided on first sliding equipment；
Second sliding equipment is arranged on first sliding equipment, and second sliding equipment can be along second direction
Sliding.
3. detection device according to claim 2, which is characterized in that the unit that hooks up includes that setting is sliding described second
Lifting device on motivation structure has the elevating lever that can be accommodated in the pick-up hole of glass item on the lifting device.
4. detection device according to claim 3, which is characterized in that first sliding equipment includes sliding rail and being capable of edge
The sliding block of the sliding rail sliding, the groove and second sliding equipment are respectively provided on the slide block, and described second is sliding
The glide direction of motivation structure is parallel to the groove, and the surface of the groove is arranged in the elevating lever.
5. detection device according to claim 1, which is characterized in that the light swashs reading module and includes:
Unit is excited, for emitting exciting light；
Detection unit is adopted for receiving the optical signal issued after sample to be tested is excited, and to the received optical signal of institute
Collection processing；
Optical path component, the optical signal for generating after the sample to be tested is excited import the detection unit.
6. detection device according to claim 5, which is characterized in that the excitation unit includes exciter, the excitation
Device can emit the red exciting light of 600~700nm.
7. detection device according to claim 5, which is characterized in that the excitation unit further includes excitation light switch, institute
Excitation light switch is stated for controlling the conducting and blocking of the exciting light by the excitation unit transmitting.
8. detection device according to claim 5, which is characterized in that the detection unit includes detector, the detection
Device is selected from single photon counter, photomultiplier tube, silicon photocell or light-measuring integrating sphere.
9. detection device according to claim 7, which is characterized in that the detection unit further includes receiving photoswitch, institute
It states and receives conducting or blocking that photoswitch is used to control generated optical signal after the sample to be tested is excited.
10. detection device according to claim 9, which is characterized in that the excitation light switch and the reception photoswitch
It is all connected with control device, the control device for making when the excitation light switch is connected, close by the reception photoswitch, and
And when reception photoswitch conducting, the excitation light switch is closed.
11. a kind of full-automatic light-induced chemiluminescent detector, which is characterized in that including according to claim 1 any one of -10 institutes
The detection device stated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810398599.7A CN110412019A (en) | 2018-04-28 | 2018-04-28 | A kind of detection device and full-automatic light-induced chemiluminescent detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810398599.7A CN110412019A (en) | 2018-04-28 | 2018-04-28 | A kind of detection device and full-automatic light-induced chemiluminescent detector |
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| Publication Number | Publication Date |
|---|---|
| CN110412019A true CN110412019A (en) | 2019-11-05 |
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|---|---|---|---|
| CN201810398599.7A Pending CN110412019A (en) | 2018-04-28 | 2018-04-28 | A kind of detection device and full-automatic light-induced chemiluminescent detector |
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| CN (1) | CN110412019A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0710836A2 (en) * | 1994-11-07 | 1996-05-08 | Jasco Corporation | Light detection apparatus for liquid chromatographs |
| CN103884854A (en) * | 2014-04-01 | 2014-06-25 | 重庆科斯迈生物科技有限公司 | Sample system of chemiluminescent immunoassay instrument |
| CN104142407A (en) * | 2013-05-10 | 2014-11-12 | 石家庄康普生科技有限公司 | Large-capacity high-speed quasi-automatic chemiluminescence immunoassay analyzer |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN104535760A (en) * | 2014-12-31 | 2015-04-22 | 重庆科斯迈生物科技有限公司 | Detecting box of chemiluminescence immunity analyzer |
| CN105044082A (en) * | 2015-06-12 | 2015-11-11 | 青岛科技大学 | Photochemical luminescent analytical instrument |
| CN105203746A (en) * | 2015-10-26 | 2015-12-30 | 深圳华迈兴微医疗科技有限公司 | POCT (Point of Care Testing) chemiluminescence immunoassay system and method |
| CN205080051U (en) * | 2015-10-07 | 2016-03-09 | 朱泽策 | Can be applied to transient state spectrum appearance and time -resolved image device's photointerrupter |
| CN206114684U (en) * | 2016-08-30 | 2017-04-19 | 重庆科斯迈生物科技有限公司 | Chemiluminescent immunoassay assay appearance cup strip hooks up push system |
| CN107271433A (en) * | 2017-06-28 | 2017-10-20 | 苏州长光华医生物医学工程有限公司 | A kind of luminous measuring method of single reaction cup |
| CN107356587A (en) * | 2017-08-24 | 2017-11-17 | 北京贝泰科技有限公司 | A kind of instant detecting system of light-induced chemiluminescent |
| CN206671346U (en) * | 2017-03-28 | 2017-11-24 | 嘉兴凯实生物科技有限公司 | A kind of detection means and full-automatic light-induced chemiluminescent detector |
| CN208366852U (en) * | 2018-04-28 | 2019-01-11 | 上海索昕生物科技有限公司 | A kind of detection device and full-automatic light-induced chemiluminescent detector |
-
2018
- 2018-04-28 CN CN201810398599.7A patent/CN110412019A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0710836A2 (en) * | 1994-11-07 | 1996-05-08 | Jasco Corporation | Light detection apparatus for liquid chromatographs |
| CN104142407A (en) * | 2013-05-10 | 2014-11-12 | 石家庄康普生科技有限公司 | Large-capacity high-speed quasi-automatic chemiluminescence immunoassay analyzer |
| CN104297498A (en) * | 2013-07-16 | 2015-01-21 | 合肥运涛光电科技有限公司 | Fully automatic biochemical and luminescent immunoassay system |
| CN103884854A (en) * | 2014-04-01 | 2014-06-25 | 重庆科斯迈生物科技有限公司 | Sample system of chemiluminescent immunoassay instrument |
| CN104535760A (en) * | 2014-12-31 | 2015-04-22 | 重庆科斯迈生物科技有限公司 | Detecting box of chemiluminescence immunity analyzer |
| CN105044082A (en) * | 2015-06-12 | 2015-11-11 | 青岛科技大学 | Photochemical luminescent analytical instrument |
| CN205080051U (en) * | 2015-10-07 | 2016-03-09 | 朱泽策 | Can be applied to transient state spectrum appearance and time -resolved image device's photointerrupter |
| CN105203746A (en) * | 2015-10-26 | 2015-12-30 | 深圳华迈兴微医疗科技有限公司 | POCT (Point of Care Testing) chemiluminescence immunoassay system and method |
| CN206114684U (en) * | 2016-08-30 | 2017-04-19 | 重庆科斯迈生物科技有限公司 | Chemiluminescent immunoassay assay appearance cup strip hooks up push system |
| CN206671346U (en) * | 2017-03-28 | 2017-11-24 | 嘉兴凯实生物科技有限公司 | A kind of detection means and full-automatic light-induced chemiluminescent detector |
| CN107271433A (en) * | 2017-06-28 | 2017-10-20 | 苏州长光华医生物医学工程有限公司 | A kind of luminous measuring method of single reaction cup |
| CN107356587A (en) * | 2017-08-24 | 2017-11-17 | 北京贝泰科技有限公司 | A kind of instant detecting system of light-induced chemiluminescent |
| CN208366852U (en) * | 2018-04-28 | 2019-01-11 | 上海索昕生物科技有限公司 | A kind of detection device and full-automatic light-induced chemiluminescent detector |
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