CN1080721C - 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 - Google Patents

1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 Download PDF

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Publication number
CN1080721C
CN1080721C CN96193768A CN96193768A CN1080721C CN 1080721 C CN1080721 C CN 1080721C CN 96193768 A CN96193768 A CN 96193768A CN 96193768 A CN96193768 A CN 96193768A CN 1080721 C CN1080721 C CN 1080721C
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CN
China
Prior art keywords
hydrochloride
isoquinolinesulfonyl
homopiperazine
trihydrate
tablet
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN96193768A
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English (en)
Chinese (zh)
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CN1183782A (zh
Inventor
川久保弘
大野胜
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Asahi Kasei Corp
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Asahi Kasei Corp
Asahi Kasei Kogyo KK
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Publication of CN1183782A publication Critical patent/CN1183782A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN96193768A 1995-07-03 1996-06-19 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 Expired - Fee Related CN1080721C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP167460/95 1995-07-03
JP16746095 1995-07-03

Publications (2)

Publication Number Publication Date
CN1183782A CN1183782A (zh) 1998-06-03
CN1080721C true CN1080721C (zh) 2002-03-13

Family

ID=15850096

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96193768A Expired - Fee Related CN1080721C (zh) 1995-07-03 1996-06-19 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物

Country Status (7)

Country Link
US (1) US5942505A (https=)
EP (1) EP0870767B1 (https=)
KR (1) KR100236853B1 (https=)
CN (1) CN1080721C (https=)
DE (1) DE69606721T2 (https=)
ES (1) ES2142065T3 (https=)
WO (1) WO1997002260A1 (https=)

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US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
CN100444843C (zh) * 1998-08-10 2008-12-24 旭化成制药株式会社 法舒地尔盐酸盐缓释口服制剂
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
WO2004105757A2 (en) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Use of rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
JP4854070B2 (ja) * 2004-01-29 2012-01-11 旭化成ファーマ株式会社 バイパス術に伴う血管攣縮治療剤
CN1929847B (zh) * 2004-03-16 2011-01-19 旭化成制药株式会社 含有法舒地尔的制剂及改善其稳定性的方法
MY139797A (en) * 2004-11-29 2009-10-30 Kowa Co (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
WO2007050783A2 (en) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
CA2638802A1 (en) * 2006-01-27 2007-10-25 Translational Genomics Research Institute Genes affecting human memory performance
CN101092413B (zh) * 2006-06-23 2011-05-18 山东轩竹医药科技有限公司 法舒地尔的药用盐的水合物
WO2008019395A2 (en) * 2006-08-10 2008-02-14 Translational Genomics Research Institute Compounds for improving learning and memory
CN102002036B (zh) * 2009-08-31 2013-01-30 秦引林 一种法舒地尔的精制方法
CN102020635B (zh) * 2009-09-10 2013-04-17 河北凯盛医药科技有限公司 一种盐酸法舒地尔半水合物的制备方法
EP2332917B1 (en) 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Compounds for PIM kinase inhibition and for treating malignancy
CN101985444B (zh) * 2010-08-20 2013-04-24 天津红日药业股份有限公司 盐酸法舒地尔的v晶型及其制备方法和用途
CN101962379B (zh) * 2010-09-28 2013-02-27 山西普德药业股份有限公司 一种磺酰基异喹啉衍生物的精制方法
CN102020636A (zh) * 2010-11-25 2011-04-20 江苏万邦生化医药股份有限公司 盐酸法舒地尔的合成及提纯方法
CN102060845B (zh) * 2010-12-28 2013-07-03 天津红日药业股份有限公司 一种法舒地尔的晶型ⅲ及其制备方法和用途
CN102225929B (zh) * 2011-05-12 2014-07-16 天津市汉康医药生物技术有限公司 一种稳定的盐酸法舒地尔水合物化合物
CN102229601B (zh) * 2011-05-12 2013-07-03 天津市汉康医药生物技术有限公司 六氢-1-(5-异喹啉磺酰基)-1(h)-1,4-二氮杂卓盐酸盐无定形化合物
US9980972B2 (en) 2012-03-12 2018-05-29 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Rho kinase inhibitors for use in treating familial amyotrophic lateral sclerosis
US8715764B2 (en) 2012-06-21 2014-05-06 Choco Finesse LLC Eutectic mixtures of esterified propoxylated glycerols with digestible fats
CN104327052A (zh) * 2014-10-20 2015-02-04 郑州四环医药用品有限公司 一种高纯度盐酸法舒地尔的制备方法
CN104945381B (zh) * 2015-06-24 2019-05-03 山东罗欣药业集团股份有限公司 一种盐酸法舒地尔化合物、其制备方法及其药物组合物
US11878023B2 (en) 2017-10-25 2024-01-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents
CA3120751A1 (en) 2018-12-17 2020-06-25 D. Western Therapeutics Institute, Inc. New form of isoquinoline sulfonamide
CN109776497A (zh) * 2019-03-07 2019-05-21 山东新华制药股份有限公司 一种盐酸法舒地尔半水合物的制备方法
WO2020193802A1 (en) 2019-03-28 2020-10-01 Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe Polymeric conjugates and uses thereof
CN113968841B (zh) * 2020-07-23 2024-05-14 合肥久诺医药科技有限公司 一种盐酸法舒地尔半水合物的制备方法
EP4422626A1 (en) 2021-10-30 2024-09-04 Aneuryst, Inc Treatments for disturbed cerebral homeostasis
EP4479035A4 (en) 2022-02-17 2026-02-25 Woolsey Pharmaceuticals Inc FASUDIL TASTE MASKING ORAL FORMULATIONS
CN118922193A (zh) 2022-02-17 2024-11-08 悟而喜制药公司 具有离子交换树脂的法舒地尔口服制剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152658A (ja) * 1984-12-27 1986-07-11 Asahi Chem Ind Co Ltd 置換されたイソキノリンスルホンアミド誘導体
JPS6293643A (ja) * 1985-10-19 1987-04-30 Fuji Photo Film Co Ltd 核酸の塩基配列決定のための信号処理方法
JPH02256617A (ja) * 1989-03-30 1990-10-17 Asahi Chem Ind Co Ltd 脳細胞機能障害改善剤
JPH04278094A (ja) * 1991-03-07 1992-10-02 Asahi Chem Ind Co Ltd １−ヒドロキシ−イソキノリンスルホンアミド誘導体の製造方法
JPH05569A (ja) * 1991-06-25 1993-01-08 Kanzaki Paper Mfg Co Ltd 感熱記録体
JPH0741424A (ja) * 1993-07-28 1995-02-10 Asahi Chem Ind Co Ltd 抗炎症剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) * 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPH0680569A (ja) * 1992-09-03 1994-03-22 Asahi Chem Ind Co Ltd 血小板凝集阻害剤
JP3464012B2 (ja) * 1993-04-05 2003-11-05 旭化成株式会社 精神症候治療剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152658A (ja) * 1984-12-27 1986-07-11 Asahi Chem Ind Co Ltd 置換されたイソキノリンスルホンアミド誘導体
JPS6293643A (ja) * 1985-10-19 1987-04-30 Fuji Photo Film Co Ltd 核酸の塩基配列決定のための信号処理方法
JPH02256617A (ja) * 1989-03-30 1990-10-17 Asahi Chem Ind Co Ltd 脳細胞機能障害改善剤
JPH04278094A (ja) * 1991-03-07 1992-10-02 Asahi Chem Ind Co Ltd １−ヒドロキシ−イソキノリンスルホンアミド誘導体の製造方法
JPH05569A (ja) * 1991-06-25 1993-01-08 Kanzaki Paper Mfg Co Ltd 感熱記録体
JPH0741424A (ja) * 1993-07-28 1995-02-10 Asahi Chem Ind Co Ltd 抗炎症剤

Also Published As

Publication number Publication date
DE69606721D1 (de) 2000-03-23
CN1183782A (zh) 1998-06-03
KR100236853B1 (ko) 2000-02-01
DE69606721T2 (de) 2000-06-21
EP0870767A4 (https=) 1998-10-14
EP0870767B1 (en) 2000-02-16
EP0870767A1 (en) 1998-10-14
HK1013598A1 (en) 1999-09-03
ES2142065T3 (es) 2000-04-01
WO1997002260A1 (en) 1997-01-23
KR19990008278A (ko) 1999-01-25
US5942505A (en) 1999-08-24

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