CN107835818B - 驱虫缩酚酸肽化合物 - Google Patents

驱虫缩酚酸肽化合物 Download PDF

Info

Publication number
CN107835818B
CN107835818B CN201680041057.3A CN201680041057A CN107835818B CN 107835818 B CN107835818 B CN 107835818B CN 201680041057 A CN201680041057 A CN 201680041057A CN 107835818 B CN107835818 B CN 107835818B
Authority
CN
China
Prior art keywords
independently
alkyl
substituted
group
fluorines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680041057.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN107835818A (zh
Inventor
L·L·H·德法罗伊斯
G·帕科夫斯基
A·龙
C·孟
李衡翼
C·O·奥格布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Priority to CN202210386076.7A priority Critical patent/CN114891070A/zh
Publication of CN107835818A publication Critical patent/CN107835818A/zh
Application granted granted Critical
Publication of CN107835818B publication Critical patent/CN107835818B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P17/00—Pest repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
CN201680041057.3A 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物 Expired - Fee Related CN107835818B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210386076.7A CN114891070A (zh) 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163997P 2015-05-20 2015-05-20
US62/163,997 2015-05-20
PCT/US2016/033522 WO2016187534A1 (en) 2015-05-20 2016-05-20 Anthelmintic depsipeptide compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210386076.7A Division CN114891070A (zh) 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物

Publications (2)

Publication Number Publication Date
CN107835818A CN107835818A (zh) 2018-03-23
CN107835818B true CN107835818B (zh) 2022-04-29

Family

ID=56322274

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680041057.3A Expired - Fee Related CN107835818B (zh) 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物
CN202210386076.7A Pending CN114891070A (zh) 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210386076.7A Pending CN114891070A (zh) 2015-05-20 2016-05-20 驱虫缩酚酸肽化合物

Country Status (32)

Country Link
US (3) US10081656B2 (https=)
EP (2) EP3298027B1 (https=)
JP (2) JP7045191B2 (https=)
KR (1) KR20180002886A (https=)
CN (2) CN107835818B (https=)
AR (1) AR104714A1 (https=)
AU (2) AU2016264635B2 (https=)
BR (1) BR112017024773A2 (https=)
CA (1) CA2986478C (https=)
CL (1) CL2017002936A1 (https=)
CO (1) CO2017011738A2 (https=)
CY (1) CY1124370T1 (https=)
DK (1) DK3298027T3 (https=)
ES (1) ES2916216T3 (https=)
HR (1) HRP20211041T1 (https=)
HU (1) HUE055535T2 (https=)
IL (1) IL255735B (https=)
LT (1) LT3298027T (https=)
MX (2) MX395486B (https=)
NZ (1) NZ737610A (https=)
PH (1) PH12017502106A1 (https=)
PL (1) PL3298027T3 (https=)
PT (1) PT3298027T (https=)
RS (1) RS62130B1 (https=)
RU (1) RU2707298C2 (https=)
SG (1) SG10202103403SA (https=)
SI (1) SI3298027T1 (https=)
SM (1) SMT202100417T1 (https=)
TW (2) TWI749509B (https=)
UY (1) UY36683A (https=)
WO (1) WO2016187534A1 (https=)
ZA (2) ZA201707806B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3298027T (lt) 2015-05-20 2021-08-10 Boehringer Ingelheim Animal Health USA Inc. Antihelmintiniai depsipeptido junginiai
RU2715556C2 (ru) * 2015-12-28 2020-03-02 Мериал, Инк. Противогельминтные депсипептидные соединения
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
EP3579696B1 (en) 2017-02-08 2023-06-28 Boehringer Ingelheim Animal Health USA Inc. In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm
GB201713633D0 (en) * 2017-08-24 2017-10-11 Walshe Nigel Methods for production of emodepside from pf 1022a derivatives
PL3676265T3 (pl) * 2017-11-07 2025-12-15 Elanco Animal Health Gmbh Sposób syntezy cyklicznych depsypeptydów
AU2018374849B2 (en) * 2017-11-29 2021-02-18 Zoetis Services Llc Endoparasitic depsipeptides
EP3749096A1 (en) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
SG11202010187RA (en) * 2018-05-10 2020-11-27 Zoetis Services Llc Endoparasitic depsipeptides
US20220071183A1 (en) 2019-01-10 2022-03-10 Zoetis Services Llc Anthelmintic laboratory animal model for heartworm
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
CN110343056B (zh) * 2019-07-19 2022-01-07 爱斯特（成都）生物制药股份有限公司 一种n-叔丁氧羰基-n-甲基-2-氨基-4,4-二甲基戊酸的制备方法
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
CN114920669A (zh) * 2022-06-28 2022-08-19 吉尔多肽生物制药(大连市)有限公司 一种n-甲基-n-苄氧羰基-l-天门冬氨酸（4-叔丁酯）二环己胺盐的合成方法
CN116606237A (zh) * 2023-05-23 2023-08-18 上海吉奉生物科技有限公司 一种色氨酸衍生物的合成方法
CN116640091A (zh) * 2023-05-25 2023-08-25 上海吉奉生物科技有限公司 一种Boc-3-（3-吡啶基）- L -丙氨酸的合成方法
CN116655534A (zh) * 2023-06-07 2023-08-29 上海吉奉生物科技有限公司 一种Boc-3-（3-吡唑）- L -丙氨酸的合成方法
EP4538282A1 (en) * 2023-10-13 2025-04-16 Vetoquinol SA Synthesis of emodepside

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19828043A1 (de) * 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
CN1293664A (zh) * 1998-03-17 2001-05-02 拜尔公司 环八缩肽类和其用于防治体内寄生虫的应用

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (https=) 1972-06-08 1974-02-08
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (https=) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
EP0179022B1 (de) 1984-10-18 1990-11-07 Ciba-Geigy Ag Benzoylphenylharnstoffe
DE3681465D1 (https=) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
DE3785936T2 (de) 1986-03-25 1993-08-26 Sankyo Co Makrolid-derivate, ihre herstellung und ihre verwendung.
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
DE3888936T2 (de) 1987-11-03 1994-07-21 Beecham Group Plc Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
MA21697A1 (fr) 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5202242A (en) 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
ES2166359T3 (es) 1992-03-17 2002-04-16 Fujisawa Pharmaceutical Co Derivado de depsipeptido, su produccion y uso.
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
US5591606A (en) 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
AU695021B2 (en) * 1993-02-19 1998-08-06 Meiji Seika Kaisha Ltd. PF1022 derivative cyclic depsipeptide
DE69402308T2 (de) 1993-03-12 1997-10-23 Dowelanco Neue a83543 verbindungen und verfahren zu ihrer herstellung
DE4317432A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317457A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
WO1995007272A1 (fr) 1993-09-06 1995-03-16 Fujisawa Pharmaceutical Co., Ltd. Compose de cyclodepsipeptide
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
DE4400464A1 (de) 1994-01-11 1995-07-13 Bayer Ag Endoparasitizide Mittel
US5750548A (en) 1994-01-24 1998-05-12 Novartis Corp. 1- N-(halo-3-pyridylmethyl)!-N-methylamino-1-alklamino-2-nitroethylene derivatives for controlling fleas in domestic animals
DE4437198A1 (de) 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520275A1 (de) 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
WO1997000944A1 (en) 1995-06-22 1997-01-09 Meiji Seika Kaisha, Ltd. Transformant producing substance pf1022 and method for transforming microorganism belonging to the class hyphomycetes
WO1997002256A1 (en) 1995-06-30 1997-01-23 Fujisawa Pharmaceutical Co., Ltd. Depsipeptide derivative, process for production thereof, and novel intermediate therefor
MY113806A (en) 1995-07-21 2002-05-31 Upjohn Co Antiparasitic marcfortines and paraherquamides
KR19990063676A (ko) 1995-09-22 1999-07-26 빌프리더 하이더 신규한 환상 데프시펩티드 pf1022 유도체
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
DE19545639A1 (de) 1995-12-07 1997-06-12 Bayer Ag Verfahren zur Herstellung von substituierten Arylmilchsäure-haltigen Cyclodepsipeptiden mit 24 Ringatomen
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
US6001981A (en) 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
EP0953563B1 (en) 1996-10-07 2003-04-16 Fujisawa Pharmaceutical Co., Ltd. Process for producing depsipeptide derivatives and novel intermediates therefor
DE19713626A1 (de) 1997-04-02 1998-10-08 Bayer Ag Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung
NZ501478A (en) * 1997-06-04 2001-05-25 Bayer Ag 8,20-bis-(substituted benzyl)-desoxycyclodepsipeptides and their use for combatting endoparasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
DE19921887A1 (de) 1999-05-12 2000-11-16 Bayer Ag Endoparasitizide Mittel
DE19926620A1 (de) * 1999-06-11 2000-12-14 Bayer Ag Neue Cycloiminodepsipeptide, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Endoparasiten
DE19962145A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
DE19962147A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel / PF 1022-221
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
DE10008128A1 (de) 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
DE10031044A1 (de) 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
DE10104362A1 (de) 2001-02-01 2002-08-08 Bayer Ag Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit
UY26592A1 (es) 2001-02-20 2001-09-28 Bayer Ag Agentes endoparasiticidas
US6893652B2 (en) 2001-08-27 2005-05-17 Wyeth Endoparasiticidal gel composition
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20040151759A1 (en) 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
AR042420A1 (es) 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
US20040236191A1 (en) 2003-05-19 2004-11-25 Poliska Steven A. System and method for identifying and labeling livestock products, and managing data associated with those products
TWI366442B (en) 2003-07-30 2012-06-21 Novartis Ag Palatable ductile chewable veterinary composition
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
ES2351972T3 (es) 2004-02-27 2011-02-14 Ic Services Procedimiento y set para la identificación de animales.
CN101768129B (zh) 2004-03-05 2012-05-23 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物的制备中间体
DE102004055316A1 (de) 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
US20060202835A1 (en) 2005-02-25 2006-09-14 Osborne Industries, Inc. Dual frequency identification device
BRPI0617076B1 (pt) 2005-09-02 2021-07-06 Nissan Chemical Corporation Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida
US7955632B2 (en) 2005-12-07 2011-06-07 Bayer B.V. Process for manufacturing chewable dosage forms for drug delivery and products thereof
JP2009519937A (ja) 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
WO2007105814A1 (ja) 2006-03-10 2007-09-20 Nissan Chemical Industries, Ltd. 置換イソキサゾリン化合物及び有害生物防除剤
MX2008013307A (es) 2006-04-20 2008-10-27 Du Pont Pirazolinas para controlar plagas de invertebrados.
JPWO2007125984A1 (ja) 2006-04-28 2009-09-10 日本農薬株式会社 イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
EP2465851A1 (en) 2006-07-05 2012-06-20 Aventis Agriculture 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
GB0623357D0 (en) * 2006-11-22 2007-01-03 Karus Therapeutics Ltd Chemical compounds
WO2008108448A1 (ja) 2007-03-07 2008-09-12 Nissan Chemical Industries, Ltd. イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
KR101538176B1 (ko) 2007-03-16 2015-07-20 구미아이 가가쿠 고교 가부시키가이샤 제초제 조성물
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
MY146638A (en) 2007-04-10 2012-09-14 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
RS55271B1 (sr) 2007-05-15 2017-02-28 Merial Sas Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene
WO2008154528A2 (en) 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
JP5349303B2 (ja) 2007-06-27 2013-11-20 日産化学工業株式会社 ３−ヒドロキシプロパン−１−オン化合物、２−プロペン−１−オン化合物およびイソキサゾリン化合物の製造方法
JP5316808B2 (ja) 2007-06-29 2013-10-16 日産化学工業株式会社 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤
ES2423505T3 (es) 2007-06-29 2013-09-20 Zoetis Llc Combinación antihelmíntica
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
JP5365806B2 (ja) 2007-09-10 2013-12-11 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
MX2010003557A (es) 2007-10-03 2010-04-12 Du Pont Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados.
DE102008022520A1 (de) 2008-05-07 2009-11-12 Bayer Animal Health Gmbh Feste Arzneimittelformulierung mit verzögerter Freisetzung
DE102008030764A1 (de) 2008-06-28 2009-12-31 Bayer Animal Health Gmbh Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
DE102008031283A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
DE102008031284A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
CN102149695B (zh) 2008-07-09 2015-02-04 日产化学工业株式会社 异*唑啉取代的苯甲酰胺化合物的制造方法
BRPI0915818A2 (pt) 2008-07-09 2015-08-04 Basf Se Mistura pesticida, composição pesticida, método para controlar fungos nocivos fitopatogênicos, para proteger plantas de fungos nocivos fitopatogênicos, para controlar insetos, aracnídeos ou nematódeos, para proteger plantas do ataque ou infestação por insetos, acarídeos ou nematódeos, e para a proteção de semente, semente, e, uso de uma mistura.
CN102088856B (zh) 2008-07-09 2015-11-25 巴斯夫欧洲公司 包含异*唑啉化合物的杀虫活性混合物i
JP2012501989A (ja) 2008-09-04 2012-01-26 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺虫化合物
US9820977B2 (en) 2008-10-03 2017-11-21 Bayer Healthcare Llc Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent
MX2011004217A (es) 2008-10-21 2011-06-20 Merial Ltd Compuestos de tioamida, metodo de elaboracion y metodo para usarlos.
EP2379731A1 (de) 2008-12-16 2011-10-26 Bayer Animal Health GmbH Verfahren zur herstellung milchsäure- und phenylmilchsäurehaltiger optisch aktiver, cyclischer depsipeptide mit 24 ringatomen mit hilfe von pilzstämmen der art rosellinia sowie weiteren gattungen xylariaceen
US8377942B2 (en) 2008-12-18 2013-02-19 Novartis Ag Isoxazolines derivatives and their use as pesticide
HUE015568T4 (en) 2008-12-19 2017-10-30 Elanco Tiergesundheit Ag Isoxazoline derivatives and their use as pesticides
EA201100980A1 (ru) 2008-12-23 2012-01-30 Басф Се Замещенные амидиновые соединения для подавления животных-вредителей
KR101002530B1 (ko) 2009-02-18 2010-12-17 삼성에스디아이 주식회사 알에프아이디 통신 장치
EP2411384B1 (en) 2009-03-26 2013-01-30 Syngenta Participations AG Insecticidal compounds
EP2414353A1 (en) 2009-04-01 2012-02-08 Basf Se Isoxazoline compounds for combating invertebrate pests
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
WO2011069995A1 (en) 2009-12-11 2011-06-16 Bayer Animal Health Gmbh Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides
RS54772B1 (sr) 2009-12-17 2016-10-31 Merial Sas Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže
US8999889B2 (en) 2010-02-01 2015-04-07 Basf Se Substituted ketonic isoxazoline compounds and derivatives for combating animal pests
BR112012021238A2 (pt) 2010-02-25 2016-06-21 Syngenta Ltd misturas pesticidas contendo derivados de isoxazolina e um fungicida
CA2790963A1 (en) 2010-02-25 2011-09-01 Syngenta Participations Ag Process for the preparation of isoxazoline derivatives
EP2538788A1 (en) 2010-02-25 2013-01-02 Syngenta Participations AG Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent
EP2556060A1 (en) 2010-04-08 2013-02-13 Ah Usa 42 Llc Substituted 3,5- diphenyl-isoxazoline derivatives as insecticides and acaricides
AR081843A1 (es) 2010-06-09 2012-10-24 Syngenta Participations Ag Mezclas pesticidas incluyendo derivados isoxazolina
US20130210623A1 (en) 2010-06-09 2013-08-15 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
UY33403A (es) 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
CN103270036B (zh) 2010-08-05 2015-11-25 佐蒂斯有限责任公司 作为抗寄生物剂的异噁唑啉衍生物
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
BR112013006686A2 (pt) 2010-09-24 2017-11-14 Zoetis Llc isoxazolina oximas como agentes antiparasitários
WO2012065031A2 (en) 2010-11-11 2012-05-18 Mlp Technology Inc. Animal data management
WO2012086462A1 (ja) 2010-12-20 2012-06-28 日本曹達株式会社 イソオキサゾリン化合物および有害生物防除剤
JP6002148B2 (ja) 2010-12-27 2016-10-05 インターベット インターナショナル ベー． フェー． 経表面局所イソオキサゾリン製剤
NZ611474A (en) 2010-12-27 2015-08-28 Intervet Int Bv Topical localized isoxazoline formulation comprising glycofurol
JP2014505089A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー 無脊椎有害動物を防除するためのイソオキサゾリン誘導体
ME02412B (me) 2011-03-10 2016-09-20 Zoetis Services Llc Spirociklični derivati izoksazolina kao antiparazitska sredstva
WO2012120135A1 (en) 2011-03-10 2012-09-13 Novartis Ag Isoxazole derivatives
US9848290B2 (en) 2011-03-10 2017-12-19 Aruba Networks, Inc. Location based computerized system and method thereof
US8614289B2 (en) * 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AU2012357848C1 (en) 2011-12-21 2018-07-19 Bayer Pharma Aktiengesellschaft Preparations containing amorphous emodepside
EP3216448B8 (en) 2012-02-06 2019-06-05 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
IN2014DN10617A (https=) * 2012-06-13 2015-09-11 Meiji Seika Pharma Co Ltd
HK1210472A1 (en) 2012-09-07 2016-04-22 Zoetis Services Llc Spirocyclic derivatives as antiparasitic agents
US9404206B2 (en) 2013-02-28 2016-08-02 Nike, Inc. Feeder for knitting machine having pushing member
US20140306005A1 (en) 2013-04-14 2014-10-16 Forever Yours, Inc. Method for Data Transport and Recovery of Dependent Creatures
WO2015066277A1 (en) 2013-11-01 2015-05-07 Merial Limited Antiparisitic and pesticidal isoxazoline compounds
LT3298027T (lt) 2015-05-20 2021-08-10 Boehringer Ingelheim Animal Health USA Inc. Antihelmintiniai depsipeptido junginiai
RU2715556C2 (ru) * 2015-12-28 2020-03-02 Мериал, Инк. Противогельминтные депсипептидные соединения
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293664A (zh) * 1998-03-17 2001-05-02 拜尔公司 环八缩肽类和其用于防治体内寄生虫的应用
DE19828043A1 (de) * 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel

Also Published As

Publication number Publication date
CA2986478C (en) 2023-08-08
US20180362589A1 (en) 2018-12-20
US12286455B2 (en) 2025-04-29
US10081656B2 (en) 2018-09-25
CO2017011738A2 (es) 2018-02-09
HUE055535T2 (hu) 2021-12-28
CN114891070A (zh) 2022-08-12
DK3298027T3 (da) 2021-08-09
HRP20211041T1 (hr) 2021-10-01
RU2707298C2 (ru) 2019-11-26
US20200354408A1 (en) 2020-11-12
KR20180002886A (ko) 2018-01-08
TWI749509B (zh) 2021-12-11
RU2017144495A3 (https=) 2019-06-20
CN107835818A (zh) 2018-03-23
ZA201907637B (en) 2023-02-22
PH12017502106A1 (en) 2018-05-28
SG10202103403SA (en) 2021-05-28
LT3298027T (lt) 2021-08-10
AU2020213297A1 (en) 2020-08-27
ES2916216T3 (es) 2022-06-29
MX379719B (es) 2025-03-11
EP3922639A1 (en) 2021-12-15
CA2986478A1 (en) 2016-11-24
AU2016264635B2 (en) 2020-05-28
IL255735B (en) 2021-03-25
TW201706287A (zh) 2017-02-16
ZA201707806B (en) 2021-06-30
HK1245285A1 (en) 2018-08-24
EP3298027A1 (en) 2018-03-28
WO2016187534A1 (en) 2016-11-24
MX2021001566A (es) 2022-09-12
NZ737610A (en) 2023-07-28
MX2017014744A (es) 2018-05-28
IL255735A (en) 2018-01-31
JP2022058535A (ja) 2022-04-12
PL3298027T3 (pl) 2021-11-08
RS62130B1 (sr) 2021-08-31
PT3298027T (pt) 2022-01-26
JP2018516904A (ja) 2018-06-28
UY36683A (es) 2016-12-30
MX395486B (es) 2025-03-25
RU2017144495A (ru) 2019-06-20
TW202108604A (zh) 2021-03-01
CY1124370T1 (el) 2022-07-22
CL2017002936A1 (es) 2018-03-16
US10793604B2 (en) 2020-10-06
AU2016264635A1 (en) 2017-12-14
TWI693237B (zh) 2020-05-11
JP7045191B2 (ja) 2022-03-31
AR104714A1 (es) 2017-08-09
BR112017024773A2 (pt) 2018-11-06
EP3298027B1 (en) 2021-04-28
SI3298027T1 (sl) 2021-08-31
SMT202100417T1 (it) 2021-09-14
US20170022253A1 (en) 2017-01-26

Similar Documents

Publication Publication Date Title
CN107835818B (zh) 驱虫缩酚酸肽化合物
CN108699052B (zh) 驱虫缩酚酸肽化合物
CN109068651B (zh) 抗寄生物的异噁唑啉化合物、包含它们的长效可注射制剂、其方法和用途
CN116249704B (zh) 驱虫用杂环化合物
CN112996788B (zh) 驱蠕虫的杂环化合物
CN106536518B (zh) 驱蠕虫化合物
CN113825543A (zh) 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
CN110167921A (zh) 驱蠕虫缩肽化合物
CN111194316A (zh) 农药的和杀寄生物的吡唑-异噁唑啉化合物
HK1245285B (en) Anthelmintic depsipeptide compounds

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20190716

Address after: Georgia

Applicant after: MERIAL, Inc.

Address before: Georgia

Applicant before: MERIAL, Inc.

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20220429