KR20180002886A - 구충성 뎁시펩티드 화합물 - Google Patents
구충성 뎁시펩티드 화합물 Download PDFInfo
- Publication number
- KR20180002886A KR20180002886A KR1020177036636A KR20177036636A KR20180002886A KR 20180002886 A KR20180002886 A KR 20180002886A KR 1020177036636 A KR1020177036636 A KR 1020177036636A KR 20177036636 A KR20177036636 A KR 20177036636A KR 20180002886 A KR20180002886 A KR 20180002886A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- independently
- group
- halogen
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- ZTLACSKWKQHBRP-TUUFMJSCSA-N N[C@H](/C=C\c1ncc(C(F)(F)F)cc1)C(O)=O Chemical compound N[C@H](/C=C\c1ncc(C(F)(F)F)cc1)C(O)=O ZTLACSKWKQHBRP-TUUFMJSCSA-N 0.000 description 1
- YZXUCQCJZKJMIR-MRVPVSSYSA-N N[C@H](Cc(cc1)ccc1OC(F)(F)F)C(O)=O Chemical compound N[C@H](Cc(cc1)ccc1OC(F)(F)F)C(O)=O YZXUCQCJZKJMIR-MRVPVSSYSA-N 0.000 description 1
- YVPYVGILADXNJV-MRVPVSSYSA-N O[C@H](Cc(cc1)ccc1Br)C(O)=O Chemical compound O[C@H](Cc(cc1)ccc1Br)C(O)=O YVPYVGILADXNJV-MRVPVSSYSA-N 0.000 description 1
- RRIKFSXQXHUQTH-CYBMUJFWSA-N O[C@H](Cc(cc1)ccc1C1=CCOCC1)C(O)=O Chemical compound O[C@H](Cc(cc1)ccc1C1=CCOCC1)C(O)=O RRIKFSXQXHUQTH-CYBMUJFWSA-N 0.000 description 1
- ZUVPFSOPNMPURJ-LJQANCHMSA-N O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O ZUVPFSOPNMPURJ-LJQANCHMSA-N 0.000 description 1
- SQRYIAOYGNJBSJ-MRVPVSSYSA-N O[C@H](Cc(cc1)ccc1OC(F)(F)F)C(O)=O Chemical compound O[C@H](Cc(cc1)ccc1OC(F)(F)F)C(O)=O SQRYIAOYGNJBSJ-MRVPVSSYSA-N 0.000 description 1
- LNFMWAJFIODBCW-OAHLLOKOSA-N O[C@H](Cc1ccc(C(F)(F)F)cc1)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc1ccc(C(F)(F)F)cc1)C(OCc1ccccc1)=O LNFMWAJFIODBCW-OAHLLOKOSA-N 0.000 description 1
- XFULYMQQCZRWQB-OAHLLOKOSA-N O[C@H](Cc1ccccc1)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc1ccccc1)C(OCc1ccccc1)=O XFULYMQQCZRWQB-OAHLLOKOSA-N 0.000 description 1
- MEKOKZJGUXMEDG-SSDOTTSWSA-N O[C@H](Cc1ncc(C(F)(F)F)cc1)C(O)=O Chemical compound O[C@H](Cc1ncc(C(F)(F)F)cc1)C(O)=O MEKOKZJGUXMEDG-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163997P | 2015-05-20 | 2015-05-20 | |
| US62/163,997 | 2015-05-20 | ||
| PCT/US2016/033522 WO2016187534A1 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180002886A true KR20180002886A (ko) | 2018-01-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177036636A Ceased KR20180002886A (ko) | 2015-05-20 | 2016-05-20 | 구충성 뎁시펩티드 화합물 |
Country Status (32)
| Country | Link |
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| US (3) | US10081656B2 (https=) |
| EP (2) | EP3298027B1 (https=) |
| JP (2) | JP7045191B2 (https=) |
| KR (1) | KR20180002886A (https=) |
| CN (2) | CN107835818B (https=) |
| AR (1) | AR104714A1 (https=) |
| AU (2) | AU2016264635B2 (https=) |
| BR (1) | BR112017024773A2 (https=) |
| CA (1) | CA2986478C (https=) |
| CL (1) | CL2017002936A1 (https=) |
| CO (1) | CO2017011738A2 (https=) |
| CY (1) | CY1124370T1 (https=) |
| DK (1) | DK3298027T3 (https=) |
| ES (1) | ES2916216T3 (https=) |
| HR (1) | HRP20211041T1 (https=) |
| HU (1) | HUE055535T2 (https=) |
| IL (1) | IL255735B (https=) |
| LT (1) | LT3298027T (https=) |
| MX (2) | MX395486B (https=) |
| NZ (1) | NZ737610A (https=) |
| PH (1) | PH12017502106A1 (https=) |
| PL (1) | PL3298027T3 (https=) |
| PT (1) | PT3298027T (https=) |
| RS (1) | RS62130B1 (https=) |
| RU (1) | RU2707298C2 (https=) |
| SG (1) | SG10202103403SA (https=) |
| SI (1) | SI3298027T1 (https=) |
| SM (1) | SMT202100417T1 (https=) |
| TW (2) | TWI749509B (https=) |
| UY (1) | UY36683A (https=) |
| WO (1) | WO2016187534A1 (https=) |
| ZA (2) | ZA201707806B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| LT3298027T (lt) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintiniai depsipeptido junginiai |
| RU2715556C2 (ru) * | 2015-12-28 | 2020-03-02 | Мериал, Инк. | Противогельминтные депсипептидные соединения |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| EP3579696B1 (en) | 2017-02-08 | 2023-06-28 | Boehringer Ingelheim Animal Health USA Inc. | In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm |
| GB201713633D0 (en) * | 2017-08-24 | 2017-10-11 | Walshe Nigel | Methods for production of emodepside from pf 1022a derivatives |
| PL3676265T3 (pl) * | 2017-11-07 | 2025-12-15 | Elanco Animal Health Gmbh | Sposób syntezy cyklicznych depsypeptydów |
| AU2018374849B2 (en) * | 2017-11-29 | 2021-02-18 | Zoetis Services Llc | Endoparasitic depsipeptides |
| EP3749096A1 (en) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| SG11202010187RA (en) * | 2018-05-10 | 2020-11-27 | Zoetis Services Llc | Endoparasitic depsipeptides |
| US20220071183A1 (en) | 2019-01-10 | 2022-03-10 | Zoetis Services Llc | Anthelmintic laboratory animal model for heartworm |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| CN110343056B (zh) * | 2019-07-19 | 2022-01-07 | 爱斯特（成都）生物制药股份有限公司 | 一种n-叔丁氧羰基-n-甲基-2-氨基-4,4-二甲基戊酸的制备方法 |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
| JP2025507585A (ja) | 2022-02-17 | 2025-03-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| CN114920669A (zh) * | 2022-06-28 | 2022-08-19 | 吉尔多肽生物制药(大连市)有限公司 | 一种n-甲基-n-苄氧羰基-l-天门冬氨酸（4-叔丁酯）二环己胺盐的合成方法 |
| CN116606237A (zh) * | 2023-05-23 | 2023-08-18 | 上海吉奉生物科技有限公司 | 一种色氨酸衍生物的合成方法 |
| CN116640091A (zh) * | 2023-05-25 | 2023-08-25 | 上海吉奉生物科技有限公司 | 一种Boc-3-（3-吡啶基）- L -丙氨酸的合成方法 |
| CN116655534A (zh) * | 2023-06-07 | 2023-08-29 | 上海吉奉生物科技有限公司 | 一种Boc-3-（3-吡唑）- L -丙氨酸的合成方法 |
| EP4538282A1 (en) * | 2023-10-13 | 2025-04-16 | Vetoquinol SA | Synthesis of emodepside |
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