CN107787364A - 用于治疗癌症的治疗组合物及使用方法 - Google Patents

用于治疗癌症的治疗组合物及使用方法 Download PDF

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CN107787364A
CN107787364A CN201680020049.0A CN201680020049A CN107787364A CN 107787364 A CN107787364 A CN 107787364A CN 201680020049 A CN201680020049 A CN 201680020049A CN 107787364 A CN107787364 A CN 107787364A
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cells
cancer
tumor
virus
cell
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U.加利利
M.韦斯特比
S.肖
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Ai Jia Seoul Immune Co Ltd
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Ai Jia Seoul Immune Co Ltd
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2710/16011—Herpesviridae
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CN201680020049.0A 2015-04-07 2016-04-07 用于治疗癌症的治疗组合物及使用方法 Pending CN107787364A (zh)

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GB1505860.5 2015-04-07
GBGB1505860.5A GB201505860D0 (en) 2015-04-07 2015-04-07 Therapeutic compositions and methods of use for treating cancer
PCT/GB2016/050973 WO2016162675A1 (en) 2015-04-07 2016-04-07 Therapeutic compositions and methods of use for treating cancer

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US (2) US20180104288A1 (enExample)
EP (1) EP3280798B1 (enExample)
JP (2) JP2018512150A (enExample)
KR (1) KR102544032B1 (enExample)
CN (1) CN107787364A (enExample)
BR (1) BR112017021700A2 (enExample)
CA (1) CA2981925C (enExample)
ES (1) ES2743952T3 (enExample)
GB (1) GB201505860D0 (enExample)
HK (1) HK1251009B (enExample)
IL (1) IL254842B (enExample)
MX (1) MX377211B (enExample)
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WO (1) WO2016162675A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112584849A (zh) * 2018-08-24 2021-03-30 杭州优善生物科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
WO2021139810A1 (en) * 2020-01-10 2021-07-15 The University Of Hong Kong Recombinant viruses expressing alpha-1, 3-galactosyltransferase and uses thereof
CN113993531A (zh) * 2019-05-14 2022-01-28 癌康理生物制药株式会社 向肿瘤组织施加溶瘤病毒的方法以及施加用装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
EP4251147A4 (en) * 2020-11-30 2025-03-19 Cornell University Cancer immunotherapies to promote hyperacute rejection
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter
CN1756568A (zh) * 2002-10-09 2006-04-05 衣阿华中央卫生系统 使用表达α(1,3)－半乳糖基转移酶的同种异型肿瘤细胞的抗肿瘤免疫
CN101056646A (zh) * 2004-11-12 2007-10-17 拜耳先灵医药股份有限公司 重组新城疫病毒
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
CN102548584A (zh) * 2009-05-06 2012-07-04 贝尔韦什生物医学研究学会 用于治疗癌症的溶瘤腺病毒
CN104093830A (zh) * 2011-04-15 2014-10-08 吉恩勒克斯公司 减毒的痘苗病毒的克隆毒株及其使用方法
CN105779397A (zh) * 2014-12-22 2016-07-20 彭霞 溶瘤异源重组新城疫病毒及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615794D0 (en) 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof
US5998174A (en) 1997-05-12 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Multigene vectors
GB9810904D0 (en) 1998-05-20 1998-07-22 Univ London Mutant herpes simplex viruses and uses thereof
KR100802403B1 (ko) 2000-01-21 2008-02-13 바이오벡스 리미티드 바이러스 주
US7338932B2 (en) * 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
US20050201993A1 (en) * 2002-10-09 2005-09-15 Link Charles J.Jr. Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
US7820628B2 (en) 2005-02-22 2010-10-26 University Of Massachusetts Medical School Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding
CN104937097B (zh) * 2012-12-07 2019-02-19 北卡罗来纳州大学 β-己糖基转移酶及其应用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter
CN1756568A (zh) * 2002-10-09 2006-04-05 衣阿华中央卫生系统 使用表达α(1,3)－半乳糖基转移酶的同种异型肿瘤细胞的抗肿瘤免疫
CN101056646A (zh) * 2004-11-12 2007-10-17 拜耳先灵医药股份有限公司 重组新城疫病毒
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
CN102548584A (zh) * 2009-05-06 2012-07-04 贝尔韦什生物医学研究学会 用于治疗癌症的溶瘤腺病毒
CN104093830A (zh) * 2011-04-15 2014-10-08 吉恩勒克斯公司 减毒的痘苗病毒的克隆毒株及其使用方法
CN105779397A (zh) * 2014-12-22 2016-07-20 彭霞 溶瘤异源重组新城疫病毒及其制备方法与应用

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANNIINA KOSKI等: "Treatment of cancer patients with serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF", 《MOLECULAR THERAPY》 *
FUEYO J等: "A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo", 《ONCOGENE》 *
LUCY DERIY等: "In vivo targeting of vaccinating tumor cells to antigen-presenting cells by a gene therapy method with adenovirus containing the [alpha]1,3galactosyltransferase gene", 《CANCER GENE THERAPY》 *
MAXINE BAUZON等: "Armed therapeutic viruses- a disruptive therapy on the horizon of cancer immunotherapy", 《FRONT IMMUNOL》 *
SEBASTIAN TUVE等: "A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells", 《JOURNAL OF VIROLOGY》 *
SIMONA BRAMANTE等: "Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: results in vitro, in rodents and in humans", 《INTERNATIONAL JOURNAL OF CANCER》 *
URI GALILI等: "Anti-gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits", 《IMMUNOLOGY》 *
张唯等: "双靶向溶瘤腺病毒对肿瘤细胞及正常细胞的杀伤差异性研究", 《华东师范大学学报（自然科学版）》 *
王宏芳等: "双重靶向条件复制型腺病毒的包装及抗肿瘤作用 ", 《西安交通大学学报(医学版)》 *
韩明勇等主编: "《肿瘤分子靶向治疗学》", 31 August 2008, 济南出版社 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112584849A (zh) * 2018-08-24 2021-03-30 杭州优善生物科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
CN113993531A (zh) * 2019-05-14 2022-01-28 癌康理生物制药株式会社 向肿瘤组织施加溶瘤病毒的方法以及施加用装置
WO2021139810A1 (en) * 2020-01-10 2021-07-15 The University Of Hong Kong Recombinant viruses expressing alpha-1, 3-galactosyltransferase and uses thereof
CN115103905A (zh) * 2020-01-10 2022-09-23 香港大学 表达α-1,3-半乳糖基转移酶的重组病毒及其用途
CN115103905B (zh) * 2020-01-10 2025-02-21 香港大学 表达α-1,3-半乳糖基转移酶的重组病毒及其用途

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HK1251009B (en) 2020-06-26
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EP3280798A1 (en) 2018-02-14
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IL254842A0 (en) 2017-12-31
CA2981925A1 (en) 2016-10-13
ES2743952T3 (es) 2020-02-21
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US20200155626A1 (en) 2020-05-21
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