RU2720984C2 - Терапевтические композиции и способы применения для лечения рака - Google Patents

Терапевтические композиции и способы применения для лечения рака Download PDF

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RU2720984C2
RU2720984C2 RU2017134519A RU2017134519A RU2720984C2 RU 2720984 C2 RU2720984 C2 RU 2720984C2 RU 2017134519 A RU2017134519 A RU 2017134519A RU 2017134519 A RU2017134519 A RU 2017134519A RU 2720984 C2 RU2720984 C2 RU 2720984C2
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cells
cancer
virus
tumor
alpha
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RU2017134519A3 (enExample
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Ури ГАЛИЛИ
Майкл ВЕСТБИ
Стивен ШО
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Агалиммьюн Лимитед
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RU2017134519A 2015-04-07 2016-04-07 Терапевтические композиции и способы применения для лечения рака RU2720984C2 (ru)

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Application Number Priority Date Filing Date Title
GB1505860.5 2015-04-07
GBGB1505860.5A GB201505860D0 (en) 2015-04-07 2015-04-07 Therapeutic compositions and methods of use for treating cancer
PCT/GB2016/050973 WO2016162675A1 (en) 2015-04-07 2016-04-07 Therapeutic compositions and methods of use for treating cancer

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RU2017134519A RU2017134519A (ru) 2019-04-04
RU2017134519A3 RU2017134519A3 (enExample) 2019-10-10
RU2720984C2 true RU2720984C2 (ru) 2020-05-15

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Publication number Priority date Publication date Assignee Title
CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
US20220249127A1 (en) * 2019-05-14 2022-08-11 Oncolys Biopharma Inc. Method for administering oncolytic virus to tumor tissue, and device for administration
CN115103905B (zh) * 2020-01-10 2025-02-21 香港大学 表达α-1,3-半乳糖基转移酶的重组病毒及其用途
EP4251147A4 (en) * 2020-11-30 2025-03-19 Cornell University Cancer immunotherapies to promote hyperacute rejection
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186850A1 (en) * 2000-05-11 2003-10-02 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
US20050201993A1 (en) * 2002-10-09 2005-09-15 Link Charles J.Jr. Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
EA013615B1 (ru) * 2004-11-12 2010-06-30 Байер Шеринг Фарма Акциенгезельшафт Рекомбинантный онколитический парамиксовирус и его применение
WO2014089558A1 (en) * 2012-12-07 2014-06-12 North Carolina State University Beta-hexosyl-transferases and uses thereof
RU2536931C2 (ru) * 2009-05-06 2014-12-27 Фундасио Институт Д`Инвестигасио Биомедика Де Бельвитге (Идибель) Онколитический аденовирус для лечения рака, его применение и фармацевтическая композиция, содержащая его

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615794D0 (en) 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof
US5998174A (en) 1997-05-12 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Multigene vectors
GB9810904D0 (en) 1998-05-20 1998-07-22 Univ London Mutant herpes simplex viruses and uses thereof
KR100802403B1 (ko) 2000-01-21 2008-02-13 바이오벡스 리미티드 바이러스 주
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter
WO2004032865A2 (en) * 2002-10-09 2004-04-22 Central Iowa Health System Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
US7820628B2 (en) 2005-02-22 2010-10-26 University Of Massachusetts Medical School Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
WO2012142529A2 (en) * 2011-04-15 2012-10-18 Genelux Corporation Clonal strains of attenuated vaccinia viruses and methods of use thereof
CN105779397B (zh) * 2014-12-22 2019-07-19 彭霞 溶瘤异源重组新城疫病毒及其制备方法与应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186850A1 (en) * 2000-05-11 2003-10-02 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
US20050201993A1 (en) * 2002-10-09 2005-09-15 Link Charles J.Jr. Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
EA013615B1 (ru) * 2004-11-12 2010-06-30 Байер Шеринг Фарма Акциенгезельшафт Рекомбинантный онколитический парамиксовирус и его применение
RU2536931C2 (ru) * 2009-05-06 2014-12-27 Фундасио Институт Д`Инвестигасио Биомедика Де Бельвитге (Идибель) Онколитический аденовирус для лечения рака, его применение и фармацевтическая композиция, содержащая его
WO2014089558A1 (en) * 2012-12-07 2014-06-12 North Carolina State University Beta-hexosyl-transferases and uses thereof

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EP3280798B1 (en) 2019-06-19
CN107787364A (zh) 2018-03-09
IL254842B (en) 2022-01-01
RU2017134519A (ru) 2019-04-04
RU2017134519A3 (enExample) 2019-10-10
HK1251009B (en) 2020-06-26
WO2016162675A1 (en) 2016-10-13
CA2981925C (en) 2025-03-11
MX377211B (es) 2025-03-07
EP3280798A1 (en) 2018-02-14
JP2018512150A (ja) 2018-05-17
IL254842A0 (en) 2017-12-31
CA2981925A1 (en) 2016-10-13
ES2743952T3 (es) 2020-02-21
BR112017021700A2 (pt) 2018-07-24
US20200155626A1 (en) 2020-05-21
MX2017012867A (es) 2018-05-11
GB201505860D0 (en) 2015-05-20
KR102544032B1 (ko) 2023-06-14
JP2021045152A (ja) 2021-03-25
JP7066812B2 (ja) 2022-05-13
US12023362B2 (en) 2024-07-02
US20180104288A1 (en) 2018-04-19
KR20180015113A (ko) 2018-02-12

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