JP2018512150A - 癌を治療するための治療用組成物及び使用方法 - Google Patents

癌を治療するための治療用組成物及び使用方法 Download PDF

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JP2018512150A
JP2018512150A JP2017552992A JP2017552992A JP2018512150A JP 2018512150 A JP2018512150 A JP 2018512150A JP 2017552992 A JP2017552992 A JP 2017552992A JP 2017552992 A JP2017552992 A JP 2017552992A JP 2018512150 A JP2018512150 A JP 2018512150A
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tumor
cells
virus
cancer
cell
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JP2018512150A5 (enExample
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ガリリ ウリ
ガリリ ウリ
ウエストバイ マイケル
ウエストバイ マイケル
ショー スティーブン
ショー スティーブン
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アガリムネ リミテッド
アガリムネ リミテッド
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/10—Transferases (2.)
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
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    • C12N2710/10011—Adenoviridae
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    • C12N2710/16011—Herpesviridae
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/16011—Herpesviridae
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01057—Phosphatidylinositol alpha-mannosyltransferase (2.4.1.57)

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JP2017552992A 2015-04-07 2016-04-07 癌を治療するための治療用組成物及び使用方法 Pending JP2018512150A (ja)

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GB1505860.5 2015-04-07
GBGB1505860.5A GB201505860D0 (en) 2015-04-07 2015-04-07 Therapeutic compositions and methods of use for treating cancer
PCT/GB2016/050973 WO2016162675A1 (en) 2015-04-07 2016-04-07 Therapeutic compositions and methods of use for treating cancer

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US (2) US20180104288A1 (enExample)
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CN (1) CN107787364A (enExample)
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CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
US20220249127A1 (en) * 2019-05-14 2022-08-11 Oncolys Biopharma Inc. Method for administering oncolytic virus to tumor tissue, and device for administration
CN115103905B (zh) * 2020-01-10 2025-02-21 香港大学 表达α-1,3-半乳糖基转移酶的重组病毒及其用途
EP4251147A4 (en) * 2020-11-30 2025-03-19 Cornell University Cancer immunotherapies to promote hyperacute rejection
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615794D0 (en) 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof
US5998174A (en) 1997-05-12 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Multigene vectors
GB9810904D0 (en) 1998-05-20 1998-07-22 Univ London Mutant herpes simplex viruses and uses thereof
KR100802403B1 (ko) 2000-01-21 2008-02-13 바이오벡스 리미티드 바이러스 주
US7338932B2 (en) * 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
WO2004032865A2 (en) * 2002-10-09 2004-04-22 Central Iowa Health System Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
US20050201993A1 (en) * 2002-10-09 2005-09-15 Link Charles J.Jr. Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
NZ581958A (en) * 2004-11-12 2011-01-28 Bayer Schering Pharma Ag Recombinant newcastle disease virus comprising a transgene encoding a prodrug-converting enzyme or protease for use in the treatment of cancer
US7820628B2 (en) 2005-02-22 2010-10-26 University Of Massachusetts Medical School Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
ES2385251B1 (es) * 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
WO2012142529A2 (en) * 2011-04-15 2012-10-18 Genelux Corporation Clonal strains of attenuated vaccinia viruses and methods of use thereof
CN104937097B (zh) * 2012-12-07 2019-02-19 北卡罗来纳州大学 β-己糖基转移酶及其应用
CN105779397B (zh) * 2014-12-22 2019-07-19 彭霞 溶瘤异源重组新城疫病毒及其制备方法与应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANCER GENE THER. (2005) VOL.12, ISSUE 6, P.528-539, JPN6020003413, ISSN: 0004204275 *
HUM. GENE THER. (2011) VOL.22, NO.11, P.1343-1353, JPN6020003415, ISSN: 0004204276 *
MOL. THER. (2003) VOL.8, NO.3, P.449-458, JPN6020003411, ISSN: 0004317854 *
MOL. THER. (2010) VOL.18, NO.10, P.1874-1884, JPN6020003409, ISSN: 0004317853 *

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CN107787364A (zh) 2018-03-09
IL254842B (en) 2022-01-01
RU2017134519A (ru) 2019-04-04
RU2017134519A3 (enExample) 2019-10-10
HK1251009B (en) 2020-06-26
WO2016162675A1 (en) 2016-10-13
CA2981925C (en) 2025-03-11
MX377211B (es) 2025-03-07
EP3280798A1 (en) 2018-02-14
IL254842A0 (en) 2017-12-31
CA2981925A1 (en) 2016-10-13
ES2743952T3 (es) 2020-02-21
BR112017021700A2 (pt) 2018-07-24
US20200155626A1 (en) 2020-05-21
MX2017012867A (es) 2018-05-11
GB201505860D0 (en) 2015-05-20
KR102544032B1 (ko) 2023-06-14
JP2021045152A (ja) 2021-03-25
RU2720984C2 (ru) 2020-05-15
JP7066812B2 (ja) 2022-05-13
US12023362B2 (en) 2024-07-02
US20180104288A1 (en) 2018-04-19
KR20180015113A (ko) 2018-02-12

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