CN107630017A - 工程化破囊壶菌属微生物 - Google Patents

工程化破囊壶菌属微生物 Download PDF

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Publication number
CN107630017A
CN107630017A CN201710887601.2A CN201710887601A CN107630017A CN 107630017 A CN107630017 A CN 107630017A CN 201710887601 A CN201710887601 A CN 201710887601A CN 107630017 A CN107630017 A CN 107630017A
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cell
thraustochytriale
seq
nucleic acid
pufa
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Chinese (zh)
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S·张
R·阿门塔
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DSM Nutritional Products AG
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DSM Nutritional Products AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
    • C12N15/8207—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated by mechanical means, e.g. microinjection, particle bombardment, silicon whiskers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201710887601.2A 2011-03-07 2012-03-07 工程化破囊壶菌属微生物 Pending CN107630017A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449848P 2011-03-07 2011-03-07
US61/449,848 2011-03-07
CN201280018055.4A CN103649313B (zh) 2011-03-07 2012-03-07 工程化破囊壶菌属微生物

Related Parent Applications (1)

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CN201280018055.4A Division CN103649313B (zh) 2011-03-07 2012-03-07 工程化破囊壶菌属微生物

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CN107630017A true CN107630017A (zh) 2018-01-26

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CN201280018055.4A Expired - Fee Related CN103649313B (zh) 2011-03-07 2012-03-07 工程化破囊壶菌属微生物

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US (2) US9133463B2 (https=)
EP (1) EP2683824B1 (https=)
JP (1) JP6168700B2 (https=)
CN (2) CN107630017A (https=)
AU (1) AU2012226528B2 (https=)
CA (1) CA2829296C (https=)
DK (1) DK2683824T3 (https=)
ES (1) ES2678997T3 (https=)
MX (1) MX338479B (https=)
NO (1) NO2773848T3 (https=)
PT (1) PT2683824T (https=)
WO (1) WO2012120375A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109517834A (zh) * 2018-11-27 2019-03-26 昆明藻能生物科技有限公司 一种通过遗传改造提高裂殖壶藻atcc20888油脂和dha含量的方法
CN117721111A (zh) * 2023-12-19 2024-03-19 海南省海洋与渔业科学院 红树植物白骨壤内源启动子amgt1p5及其应用
CN120555215A (zh) * 2025-07-29 2025-08-29 杭州合碳创物科技有限公司 一种高含量dha、低含量dpa的裂殖壶菌及其应用

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2397655C (en) 2000-01-19 2012-06-05 Craig M. Ruecker Solventless extraction process
EP2576801B1 (en) 2010-06-01 2019-10-02 DSM IP Assets B.V. Extraction of lipid from cells and products therefrom
PT2683824T (pt) * 2011-03-07 2018-06-07 Dsm Nutritional Products Ag Modificação de microorganismos thraustochytrid
EP2970926B1 (en) 2013-03-13 2018-01-31 DSM Nutritional Products AG Engineering microorganisms
CN105939710B (zh) 2013-12-20 2020-05-08 帝斯曼知识产权资产管理有限公司 用于从微生物细胞获得微生物油的方法
CN105829539B (zh) 2013-12-20 2023-11-10 帝斯曼营养品股份公司 从微生物中回收油的方法
PL3083546T3 (pl) 2013-12-20 2022-05-16 Dsm Ip Assets B.V. Sposoby wytwarzania oleju mikrobiologicznego z komórek mikrobiologicznych
FI3626806T3 (fi) 2013-12-20 2024-08-22 Mara Renewables Corp Menetelmiä öljyn talteenottamiseksi mikro-organismeista
AU2014369040B2 (en) 2013-12-20 2019-12-05 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
AR098895A1 (es) 2013-12-20 2016-06-22 Dsm Ip Assets Bv Proceso para obtener aceite microbiano a partir de células microbianas
NZ721413A (en) 2013-12-20 2022-05-27 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
KR102236782B1 (ko) 2014-05-22 2021-04-05 마라 리뉴어블즈 코퍼레이션 미생물에서 오일 생산 방법
WO2016059541A1 (en) * 2014-10-16 2016-04-21 MARA Renewables Corporation Repeated fed-batch culture methods
JP6806297B2 (ja) 2014-10-16 2021-01-06 マラ リニューアブルズ コーポレーション 半連続培養法
US9890402B2 (en) * 2015-01-24 2018-02-13 Indian Oil Corporation Limited Thraustochytrid based process for treating waste effluents
CA2977271A1 (en) 2015-03-02 2016-09-09 Synthetic Genomics, Inc. Regulatory elements from labyrinthulomycetes microorganisms
AU2016228545A1 (en) * 2015-03-12 2017-09-21 Synthetic Genomics. Inc. Microorganisms for fatty acid production using elongase and desaturase enzymes
AR104042A1 (es) 2015-03-26 2017-06-21 Mara Renewables Corp Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto
EP3318640A4 (en) * 2015-07-03 2019-03-06 Kuysyu University, National University Corporation LABYRINTHULIDE MICROORGANISM FOR THE MANUFACTURE OF MICROBIAL OIL, MICROBIAL OIL, PROCESS FOR PREPARING THE SAID MICROORGANISM AND FOR PRODUCING THE SAID MICROBIAL OIL, AND USE OF THE SAID MICROORGANISM AND THE SAID MICROBIAL OIL
EP3322796A4 (en) 2015-07-13 2019-03-27 Mara Renewables Corporation IMPROVEMENT OF MICROGENONAL FLUID CHANGES OF XYLOSE
FR3038914B1 (fr) * 2015-07-17 2020-03-13 Fermentalg Biomasse de thraustochytrides, procede de culture et utilisations
CN106916796B (zh) * 2015-12-28 2021-06-29 丰益(上海)生物技术研发中心有限公司 裂殖壶菌delta-12脂肪酸脱饱和酶相关序列及其应用
EP3795586A3 (en) * 2016-03-16 2021-06-23 Conagen Inc. Production of proteins in labyrinthulomycetes
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
US10676709B2 (en) 2016-07-20 2020-06-09 MARA Renewables Corporation Flowable microbial oil
US10059906B2 (en) 2016-07-20 2018-08-28 MARA Renewables Corporation Solventless winterization of microbial oil
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
EP3559206B1 (en) 2016-12-22 2025-12-03 Mara Renewables Corporation Methods for producing biomass rich in dha, palmitic acid and protein using a eukaryotic microorganism
AU2019371162B2 (en) 2018-11-02 2025-08-28 MARA Renewables Corporation Algal oil with improved nutritional value
US20250129395A1 (en) 2022-01-25 2025-04-24 Dsm Ip Assets B.V. Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production
US20260002223A1 (en) * 2022-06-27 2026-01-01 Wisconsin Alumni Research Foundation Universal method for parasite and eukaryotic endosymbiont identification
CN119307499B (zh) * 2024-12-18 2025-02-28 中国科学院天津工业生物技术研究所 内源tRNA启动子及破囊壶菌科微生物基因编辑方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1914327A (zh) * 2003-11-10 2007-02-14 努特诺瓦营养产品及食品成分有限公司 培养Thraustochytriales属微生物的方法
CN101573451A (zh) * 2006-03-15 2009-11-04 马泰克生物科学公司 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法
WO2010108114A2 (en) * 2009-03-19 2010-09-23 Martek Biosciences Corporation Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof
CN101849014A (zh) * 2007-05-16 2010-09-29 马泰克生物科学公司 嵌合pufa聚酮合酶系统及其用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451567B1 (en) 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
WO1997039106A1 (en) * 1996-04-12 1997-10-23 Martek Biosciences Corporation Methods and tools for transformation of eukaryotic algae
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
KR20070073986A (ko) 2000-01-28 2007-07-10 마텍 바이오싸이언스스 코포레이션 발효기 내에서 진핵 미생물의 고밀도 배양에 의한고도불포화 지방산을 함유하는 지질의 증진된 생산 방법
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7211656B2 (en) 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
JP4280158B2 (ja) 2002-12-27 2009-06-17 富士フイルム株式会社 ドコサヘキサエン酸生産能を有する微生物及びその利用
US7214491B2 (en) 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
DE102004063326A1 (de) 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
JP4796786B2 (ja) * 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類を形質転換可能なベクター
JP4796787B2 (ja) 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類への遺伝子導入法
AU2006325040B2 (en) * 2005-06-07 2012-04-19 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
CA2659603C (en) 2006-08-01 2017-03-07 Ocean Nutrition Canada Limited Oil producing microbes and methods of modification thereof
WO2009010825A2 (en) * 2007-07-13 2009-01-22 Ocean Nutrition Canada Ltd. D4 desaturases and d5 elongases
WO2011037207A1 (ja) * 2009-09-24 2011-03-31 国立大学法人九州大学 ストラメノパイルの形質転換方法
KR101068520B1 (ko) * 2009-10-07 2011-09-28 대상 주식회사 고함량의 도코사헥사엔산을 함유하는 오메가-3 불포화 지방산을 생산하는 균주 및 이를 이용한 오메가-3 불포화 지방산의 제조방법
IN2012DN06277A (https=) * 2009-12-28 2015-09-25 Dsm Ip Assets Bv
US8765404B2 (en) 2010-03-02 2014-07-01 Massachusetts Institute Of Technology Microbial engineering for the production of fatty acids and fatty acid derivatives
PT2683824T (pt) * 2011-03-07 2018-06-07 Dsm Nutritional Products Ag Modificação de microorganismos thraustochytrid
EP2970926B1 (en) * 2013-03-13 2018-01-31 DSM Nutritional Products AG Engineering microorganisms

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1914327A (zh) * 2003-11-10 2007-02-14 努特诺瓦营养产品及食品成分有限公司 培养Thraustochytriales属微生物的方法
CN101573451A (zh) * 2006-03-15 2009-11-04 马泰克生物科学公司 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法
CN101849014A (zh) * 2007-05-16 2010-09-29 马泰克生物科学公司 嵌合pufa聚酮合酶系统及其用途
WO2010108114A2 (en) * 2009-03-19 2010-09-23 Martek Biosciences Corporation Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOURCADE D E等: "《Marker rescue from bleomycin-treated Chlamydomonas reinhardi》", 《GENETICS》 *
HUANG JIAN-ZHONG等: "《Cloning and Functional Identification of Delta5 Fatty Acid Desaturase Gene and Its 5 "-Upstream Region from Marine Fungus Thraustochytrium sp. FJN-10》", 《MARINE BIOTECHNOLOGY》 *
江宁: "《微生物生物技术》", 31 December 2008, 化学工业出版社 *
齐秀兰等: "《L-赖氨酸产生菌钝齿棒杆菌高产突变株 EB0.04-14的选育》", 《沈阳药科大学学报》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109517834A (zh) * 2018-11-27 2019-03-26 昆明藻能生物科技有限公司 一种通过遗传改造提高裂殖壶藻atcc20888油脂和dha含量的方法
CN109517834B (zh) * 2018-11-27 2022-06-07 昆明藻能生物科技有限公司 一种通过遗传改造提高裂殖壶藻atcc20888油脂和dha含量的方法
CN117721111A (zh) * 2023-12-19 2024-03-19 海南省海洋与渔业科学院 红树植物白骨壤内源启动子amgt1p5及其应用
CN117721111B (zh) * 2023-12-19 2024-06-07 海南省海洋与渔业科学院 红树植物白骨壤内源启动子amgt1p5及其应用
CN120555215A (zh) * 2025-07-29 2025-08-29 杭州合碳创物科技有限公司 一种高含量dha、低含量dpa的裂殖壶菌及其应用

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CN103649313A (zh) 2014-03-19
WO2012120375A1 (en) 2012-09-13
JP6168700B2 (ja) 2017-07-26
PT2683824T (pt) 2018-06-07
US20120244584A1 (en) 2012-09-27
MX2013010167A (es) 2014-04-14
EP2683824B1 (en) 2018-04-25
MX338479B (es) 2016-04-19
CN103649313B (zh) 2017-10-24
US9758787B2 (en) 2017-09-12
CA2829296C (en) 2019-10-29
EP2683824A4 (en) 2015-05-06
US20160010095A1 (en) 2016-01-14
JP2014507952A (ja) 2014-04-03
AU2012226528A1 (en) 2013-05-02
NO2773848T3 (https=) 2018-03-31
CA2829296A1 (en) 2012-09-13
DK2683824T3 (en) 2018-06-18
EP2683824A1 (en) 2014-01-15
US9133463B2 (en) 2015-09-15
ES2678997T3 (es) 2018-08-21
AU2012226528B2 (en) 2015-08-20

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Application publication date: 20180126