CN1076199A - 新的肽衍生物 - Google Patents

新的肽衍生物 Download PDF

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Publication number
CN1076199A
CN1076199A CN92115304A CN92115304A CN1076199A CN 1076199 A CN1076199 A CN 1076199A CN 92115304 A CN92115304 A CN 92115304A CN 92115304 A CN92115304 A CN 92115304A CN 1076199 A CN1076199 A CN 1076199A
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CN
China
Prior art keywords
cha
pro
nag
hooc
pic
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Pending
Application number
CN92115304A
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English (en)
Chinese (zh)
Inventor
E·A·C·泰格-尼尔森
R·E·拜隆德
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AstraZeneca AB
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Astra AB
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Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CN1076199A publication Critical patent/CN1076199A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN92115304A 1991-12-04 1992-12-04 新的肽衍生物 Pending CN1076199A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9103612 1991-12-04
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Publications (1)

Publication Number Publication Date
CN1076199A true CN1076199A (zh) 1993-09-15

Family

ID=20384531

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92115304A Pending CN1076199A (zh) 1991-12-04 1992-12-04 新的肽衍生物

Country Status (27)

Country Link
US (4) US5614499A (enExample)
EP (1) EP0618926B1 (enExample)
JP (1) JP3306826B2 (enExample)
CN (1) CN1076199A (enExample)
AP (1) AP353A (enExample)
AT (1) ATE190066T1 (enExample)
AU (2) AU670052B2 (enExample)
CA (1) CA2125175C (enExample)
CZ (2) CZ333895A3 (enExample)
DE (1) DE69230727T2 (enExample)
EE (1) EE9400455A (enExample)
FI (1) FI115770B (enExample)
HU (1) HUT70431A (enExample)
IL (1) IL103910A0 (enExample)
IS (1) IS3954A (enExample)
MA (1) MA22729A1 (enExample)
MX (1) MX9206938A (enExample)
NO (1) NO311361B1 (enExample)
NZ (2) NZ246106A (enExample)
SE (1) SE9103612D0 (enExample)
SI (1) SI9200363A (enExample)
SK (1) SK63194A3 (enExample)
TN (1) TNSN92109A1 (enExample)
TW (1) TW223078B (enExample)
WO (1) WO1993011152A1 (enExample)
YU (1) YU104592A (enExample)
ZA (1) ZA929099B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924567A (zh) * 2008-10-28 2013-02-13 上海医药工业研究院 一类肽化合物、其制备方法及用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924567A (zh) * 2008-10-28 2013-02-13 上海医药工业研究院 一类肽化合物、其制备方法及用途
CN102924567B (zh) * 2008-10-28 2014-06-04 上海医药工业研究院 一类肽化合物、其制备方法及用途

Also Published As

Publication number Publication date
TW223078B (enExample) 1994-05-01
FI115770B (fi) 2005-07-15
CA2125175C (en) 2001-09-11
FI942645L (fi) 1994-06-03
EP0618926B1 (en) 2000-03-01
JPH09500356A (ja) 1997-01-14
AU683793B2 (en) 1997-11-20
US5736521A (en) 1998-04-07
AU3120993A (en) 1993-06-28
CZ129694A3 (en) 1994-12-15
HUT70431A (en) 1995-10-30
CA2125175A1 (en) 1993-06-10
EP0618926A1 (en) 1994-10-12
NZ280762A (en) 1998-08-26
IS3954A (is) 1993-06-05
MA22729A1 (fr) 1993-07-01
SE9103612D0 (sv) 1991-12-04
NO311361B1 (no) 2001-11-19
EE9400455A (et) 1996-06-17
TNSN92109A1 (fr) 1993-06-08
CZ333895A3 (en) 1996-04-17
AU670052B2 (en) 1996-07-04
US5955433A (en) 1999-09-21
DE69230727T2 (de) 2000-08-03
MX9206938A (es) 1993-06-01
SK63194A3 (en) 1994-12-07
WO1993011152A1 (en) 1993-06-10
US5614499A (en) 1997-03-25
FI942645A0 (fi) 1994-06-03
JP3306826B2 (ja) 2002-07-24
AP353A (en) 1994-08-14
AP9200457A0 (en) 1993-01-31
AU5061696A (en) 1996-08-01
ZA929099B (en) 1993-06-07
IL103910A0 (en) 1993-04-04
US5747460A (en) 1998-05-05
NO942066D0 (no) 1994-06-03
NO942066L (no) 1994-06-03
DE69230727D1 (de) 2000-04-06
NZ246106A (en) 1996-07-26
SI9200363A (en) 1993-06-30
YU104592A (sh) 1995-12-04
ATE190066T1 (de) 2000-03-15
HU9401474D0 (en) 1994-08-29

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