CN107567442B - C型肝炎病毒聚合酶的抑制剂 - Google Patents

C型肝炎病毒聚合酶的抑制剂 Download PDF

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Publication number
CN107567442B
CN107567442B CN201680017709.XA CN201680017709A CN107567442B CN 107567442 B CN107567442 B CN 107567442B CN 201680017709 A CN201680017709 A CN 201680017709A CN 107567442 B CN107567442 B CN 107567442B
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ethoxy
phenyl
cyclopropyl
compound
benzofuran
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CN107567442A (zh
Inventor
伊里娜·C·雅各布森
迈克尔·D·费思
萨姆·S·李
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Cocrystal Pharma Inc
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Cocrystal Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN201680017709.XA 2015-03-23 2016-03-23 C型肝炎病毒聚合酶的抑制剂 Active CN107567442B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562136857P 2015-03-23 2015-03-23
US62/136,857 2015-03-23
PCT/US2016/023664 WO2016154241A1 (en) 2015-03-23 2016-03-23 Inhibitors of hepatitis c virus polymerase

Publications (2)

Publication Number Publication Date
CN107567442A CN107567442A (zh) 2018-01-09
CN107567442B true CN107567442B (zh) 2021-05-25

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US (2) US10464914B2 (https=)
EP (1) EP3274340B1 (https=)
JP (1) JP6741747B2 (https=)
KR (1) KR20170137113A (https=)
CN (1) CN107567442B (https=)
AU (1) AU2016235246B2 (https=)
CA (1) CA2979555C (https=)
DK (1) DK3274340T3 (https=)
EA (1) EA033622B1 (https=)
ES (1) ES2748974T3 (https=)
IL (1) IL254243B (https=)
MX (1) MX379015B (https=)
NZ (1) NZ735093A (https=)
PH (1) PH12017501687A1 (https=)
PL (1) PL3274340T3 (https=)
SG (1) SG11201707527YA (https=)
TW (1) TWI731854B (https=)
WO (1) WO2016154241A1 (https=)

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TWI731854B (zh) * 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
KR20210018806A (ko) * 2018-05-09 2021-02-18 코크리스탈 파마, 아이엔씨. Hcv의 치료를 위한 병용 요법
CN112745216A (zh) * 2019-10-30 2021-05-04 常州锐博生物科技有限公司 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN114181187A (zh) * 2021-11-24 2022-03-15 上海应用技术大学 一种4-甲磺酰胺基丁酰胺化合物的制备方法
CN116283512B (zh) * 2023-02-24 2025-04-25 博诺康源(北京)药业科技有限公司 一种合成维兰特罗及其盐的方法
WO2025111414A1 (en) * 2023-11-21 2025-05-30 Katholieke Universiteit Leuven Trpm3-modulating benzofuran derivatives
CN119350612B (zh) * 2024-12-24 2025-10-24 浙江爱索拓标记医药科技有限公司 一种放射性同位素碳-14标记聚乙二醇单甲醚的合成方法

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Also Published As

Publication number Publication date
SG11201707527YA (en) 2017-10-30
PL3274340T3 (pl) 2020-01-31
CA2979555A1 (en) 2016-09-29
DK3274340T3 (da) 2019-10-07
IL254243B (en) 2020-10-29
HK1243703A1 (zh) 2018-07-20
CN107567442A (zh) 2018-01-09
EA033622B1 (ru) 2019-11-11
US20200255393A1 (en) 2020-08-13
CA2979555C (en) 2023-12-19
EP3274340B1 (en) 2019-07-17
IL254243A0 (en) 2017-10-31
EA201792094A1 (ru) 2018-03-30
US10464914B2 (en) 2019-11-05
EP3274340A1 (en) 2018-01-31
US20180050998A1 (en) 2018-02-22
MX2017012238A (es) 2018-02-15
KR20170137113A (ko) 2017-12-12
US10947210B2 (en) 2021-03-16
JP2018512453A (ja) 2018-05-17
ES2748974T3 (es) 2020-03-18
AU2016235246A1 (en) 2017-09-21
JP6741747B2 (ja) 2020-08-19
HK1249514A1 (en) 2018-11-02
AU2016235246B2 (en) 2020-12-10
NZ735093A (en) 2022-09-30
TWI731854B (zh) 2021-07-01
PH12017501687A1 (en) 2018-03-19
TW201643147A (zh) 2016-12-16
BR112017020168A2 (pt) 2018-06-05
MX379015B (es) 2025-03-10
WO2016154241A1 (en) 2016-09-29

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