MX379015B - Inhibidores de la polimerasa del virus de la hepatitis c. - Google Patents

Inhibidores de la polimerasa del virus de la hepatitis c.

Info

Publication number
MX379015B
MX379015B MX2017012238A MX2017012238A MX379015B MX 379015 B MX379015 B MX 379015B MX 2017012238 A MX2017012238 A MX 2017012238A MX 2017012238 A MX2017012238 A MX 2017012238A MX 379015 B MX379015 B MX 379015B
Authority
MX
Mexico
Prior art keywords
hepatitis
virus polymerase
polymerase inhibitors
compounds
useful
Prior art date
Application number
MX2017012238A
Other languages
English (en)
Other versions
MX2017012238A (es
Inventor
Irina C Jacobson
Michael D Feese
Sam S Lee
Original Assignee
Cocrystal Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cocrystal Pharma Inc filed Critical Cocrystal Pharma Inc
Publication of MX2017012238A publication Critical patent/MX2017012238A/es
Publication of MX379015B publication Critical patent/MX379015B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona, entre otras cosas, compuestos representados por la Fórmula general I: (Véase formula) y sus sales farmacéuticamente aceptables, en donde L y A (y otros sustituyentes) son según se definió en las clases y subclases en la presente y composiciones (por ejemplo, composiciones farmacéuticas) que comprende tales compuestos, cuyos compuestos son de utilidad como inhibidores de la polimerasa del virus de la hepatitis C y, de esta manera, son de utilidad, por ejemplo, como medicamentos para el tratamiento de infección por HCV. (virus de la hepatitis C, por sus siglas en inglés).
MX2017012238A 2015-03-23 2016-03-23 Inhibidores de la polimerasa del virus de la hepatitis c. MX379015B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562136857P 2015-03-23 2015-03-23
PCT/US2016/023664 WO2016154241A1 (en) 2015-03-23 2016-03-23 Inhibitors of hepatitis c virus polymerase

Publications (2)

Publication Number Publication Date
MX2017012238A MX2017012238A (es) 2018-02-15
MX379015B true MX379015B (es) 2025-03-10

Family

ID=55759915

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017012238A MX379015B (es) 2015-03-23 2016-03-23 Inhibidores de la polimerasa del virus de la hepatitis c.

Country Status (18)

Country Link
US (2) US10464914B2 (es)
EP (1) EP3274340B1 (es)
JP (1) JP6741747B2 (es)
KR (1) KR20170137113A (es)
CN (1) CN107567442B (es)
AU (1) AU2016235246B2 (es)
CA (1) CA2979555C (es)
DK (1) DK3274340T3 (es)
EA (1) EA033622B1 (es)
ES (1) ES2748974T3 (es)
IL (1) IL254243B (es)
MX (1) MX379015B (es)
NZ (1) NZ735093A (es)
PH (1) PH12017501687A1 (es)
PL (1) PL3274340T3 (es)
SG (1) SG11201707527YA (es)
TW (1) TWI731854B (es)
WO (1) WO2016154241A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI731854B (zh) * 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
TWI833753B (zh) * 2018-05-09 2024-03-01 美商共結晶製藥公司 用於治療hcv之組合療法
CN112745216A (zh) * 2019-10-30 2021-05-04 常州锐博生物科技有限公司 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN114181187A (zh) * 2021-11-24 2022-03-15 上海应用技术大学 一种4-甲磺酰胺基丁酰胺化合物的制备方法
CN116283512B (zh) * 2023-02-24 2025-04-25 博诺康源(北京)药业科技有限公司 一种合成维兰特罗及其盐的方法
WO2025111414A1 (en) * 2023-11-21 2025-05-30 Katholieke Universiteit Leuven Trpm3-modulating benzofuran derivatives
CN119350612B (zh) * 2024-12-24 2025-10-24 浙江爱索拓标记医药科技有限公司 一种放射性同位素碳-14标记聚乙二醇单甲醚的合成方法

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US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
CN101624391A (zh) 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US6887877B2 (en) 2001-06-11 2005-05-03 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
EP1321463B1 (en) 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
WO2004041201A2 (en) * 2002-11-01 2004-05-21 Viropharma Incorporated Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
EP1569929B9 (en) 2002-12-10 2011-09-14 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
US20040192707A1 (en) 2002-12-10 2004-09-30 Laval Chan Chun Kong Compounds and methods for the treatment or prevention of Flavivirus infections
CN100413861C (zh) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US20070293484A1 (en) 2004-05-20 2007-12-20 Sugen, Inc. Thiophene Heteroaryl Amines
DE102004061746A1 (de) 2004-12-22 2006-07-06 Bayer Healthcare Ag Alkinyl-substituierte Thiophene
US7569600B2 (en) 2005-05-13 2009-08-04 Virochem Pharma Inc. Compounds and methods for the treatment of prevention of Flavivirus infections
PE20070814A1 (es) 2005-12-22 2007-08-16 Smithkline Beecham Corp Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv)
WO2008017688A1 (en) 2006-08-11 2008-02-14 Smithkline Beecham Corporation 2-carboxy thiophene derivatives as anti-viral agents
TW200815384A (en) 2006-08-25 2008-04-01 Viropharma Inc Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein
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AR080433A1 (es) * 2010-03-02 2012-04-11 Merck Sharp & Dohme Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen.
US8324239B2 (en) * 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
TW201221131A (en) * 2010-11-18 2012-06-01 Glaxo Group Ltd Compounds
TW201307334A (zh) 2010-12-17 2013-02-16 Cocrystal Discovery Inc Ｃ型肝炎病毒聚合酶抑制劑
WO2014055142A1 (en) 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
TWI731854B (zh) * 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑

Also Published As

Publication number Publication date
KR20170137113A (ko) 2017-12-12
PH12017501687A1 (en) 2018-03-19
SG11201707527YA (en) 2017-10-30
HK1249514A1 (en) 2018-11-02
TW201643147A (zh) 2016-12-16
PL3274340T3 (pl) 2020-01-31
CA2979555C (en) 2023-12-19
EP3274340A1 (en) 2018-01-31
US10464914B2 (en) 2019-11-05
US20180050998A1 (en) 2018-02-22
CN107567442B (zh) 2021-05-25
DK3274340T3 (da) 2019-10-07
AU2016235246B2 (en) 2020-12-10
AU2016235246A1 (en) 2017-09-21
US20200255393A1 (en) 2020-08-13
HK1243703A1 (zh) 2018-07-20
EP3274340B1 (en) 2019-07-17
NZ735093A (en) 2022-09-30
JP2018512453A (ja) 2018-05-17
TWI731854B (zh) 2021-07-01
CN107567442A (zh) 2018-01-09
EA033622B1 (ru) 2019-11-11
CA2979555A1 (en) 2016-09-29
EA201792094A1 (ru) 2018-03-30
JP6741747B2 (ja) 2020-08-19
IL254243A0 (en) 2017-10-31
MX2017012238A (es) 2018-02-15
US10947210B2 (en) 2021-03-16
WO2016154241A1 (en) 2016-09-29
BR112017020168A2 (pt) 2018-06-05
ES2748974T3 (es) 2020-03-18
IL254243B (en) 2020-10-29

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