HK1243703A1 - C型肝炎病毒聚合酶的抑制劑 - Google Patents
C型肝炎病毒聚合酶的抑制劑Info
- Publication number
- HK1243703A1 HK1243703A1 HK18103065.4A HK18103065A HK1243703A1 HK 1243703 A1 HK1243703 A1 HK 1243703A1 HK 18103065 A HK18103065 A HK 18103065A HK 1243703 A1 HK1243703 A1 HK 1243703A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hepatitis
- inhibitors
- virus polymerase
- polymerase
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562136857P | 2015-03-23 | 2015-03-23 | |
| PCT/US2016/023664 WO2016154241A1 (en) | 2015-03-23 | 2016-03-23 | Inhibitors of hepatitis c virus polymerase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1243703A1 true HK1243703A1 (zh) | 2018-07-20 |
Family
ID=55759915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18103065.4A HK1243703A1 (zh) | 2015-03-23 | 2018-03-02 | C型肝炎病毒聚合酶的抑制劑 |
| HK18109115.1A HK1249514A1 (zh) | 2015-03-23 | 2018-07-13 | C型肝炎病毒聚合酶的抑制劑 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18109115.1A HK1249514A1 (zh) | 2015-03-23 | 2018-07-13 | C型肝炎病毒聚合酶的抑制劑 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10464914B2 (zh) |
| EP (1) | EP3274340B1 (zh) |
| JP (1) | JP6741747B2 (zh) |
| KR (1) | KR20170137113A (zh) |
| CN (1) | CN107567442B (zh) |
| AU (1) | AU2016235246B2 (zh) |
| CA (1) | CA2979555C (zh) |
| DK (1) | DK3274340T3 (zh) |
| EA (1) | EA033622B1 (zh) |
| ES (1) | ES2748974T3 (zh) |
| HK (2) | HK1243703A1 (zh) |
| IL (1) | IL254243B (zh) |
| MX (1) | MX2017012238A (zh) |
| NZ (1) | NZ735093A (zh) |
| PH (1) | PH12017501687A1 (zh) |
| PL (1) | PL3274340T3 (zh) |
| SG (1) | SG11201707527YA (zh) |
| TW (1) | TWI731854B (zh) |
| WO (1) | WO2016154241A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| EP3790542B1 (en) * | 2018-05-09 | 2023-07-19 | Cocrystal Pharma, Inc. | Combination therapy for treatment of hcv |
| CN112745216A (zh) * | 2019-10-30 | 2021-05-04 | 常州锐博生物科技有限公司 | 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法 |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184425A (zh) | 1995-03-20 | 1998-06-10 | 伊莱利利公司 | 5－取代－3－(1,2,3,6－四氢吡啶－4－基)－和3－(哌啶－4－基)－1h－吲哚:新型5－ht1f激动剂 |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| SK288015B6 (sk) | 2001-06-11 | 2012-11-05 | Virochem Pharma Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| US6887877B2 (en) | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| DE60221627D1 (de) | 2001-12-21 | 2007-09-20 | Virochem Pharma Inc | Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren |
| KR20050065661A (ko) * | 2002-11-01 | 2005-06-29 | 비로파마 인코포레이티드 | 벤조푸란 화합물, 조성물 및 ｃ형 간염 바이러스 감염 및관련 질병의 치료 및 예방 방법 |
| JP4926403B2 (ja) | 2002-12-10 | 2012-05-09 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染の処置もしくは予防のための化合物および方法 |
| US20040192707A1 (en) | 2002-12-10 | 2004-09-30 | Laval Chan Chun Kong | Compounds and methods for the treatment or prevention of Flavivirus infections |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| BRPI0510032A (pt) | 2004-05-20 | 2007-10-02 | Sugen Inc | tiofeno heteroaril aminas |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| AP2007004245A0 (en) | 2005-05-13 | 2007-12-31 | Virochem Pharma Inc | Compounds and methods for the treatment or prevention of flavivirus infections |
| US20090136448A1 (en) | 2005-12-22 | 2009-05-28 | John Andrew Corfield | Antiviral 2-Carboxy-Thiophene Compounds |
| WO2008017688A1 (en) | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| TW200815384A (en) | 2006-08-25 | 2008-04-01 | Viropharma Inc | Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein |
| WO2008043791A2 (en) | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| NZ576780A (en) | 2006-11-15 | 2011-12-22 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| JP2010510191A (ja) | 2006-11-17 | 2010-04-02 | スミスクライン ビーチャム コーポレーション | 抗ウイルス剤としての２−カルボキシチオフェン誘導体 |
| GB0707092D0 (en) | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
| GB0712393D0 (en) | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
| WO2009101022A1 (en) | 2008-02-14 | 2009-08-20 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| WO2009137500A1 (en) * | 2008-05-05 | 2009-11-12 | Wyeth | 6-substituted benzofuran compounds to treat infection with hepatitis c virus |
| WO2011106929A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
| AR080433A1 (es) * | 2010-03-02 | 2012-04-11 | Merck Sharp & Dohme | Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen. |
| US8324239B2 (en) * | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
| TW201221131A (en) * | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
| WO2012083105A1 (en) | 2010-12-17 | 2012-06-21 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
-
2016
- 2016-03-21 TW TW105108618A patent/TWI731854B/zh active
- 2016-03-23 CN CN201680017709.XA patent/CN107567442B/zh active Active
- 2016-03-23 DK DK16717211.3T patent/DK3274340T3/da active
- 2016-03-23 WO PCT/US2016/023664 patent/WO2016154241A1/en active Application Filing
- 2016-03-23 EA EA201792094A patent/EA033622B1/ru not_active IP Right Cessation
- 2016-03-23 MX MX2017012238A patent/MX2017012238A/es unknown
- 2016-03-23 AU AU2016235246A patent/AU2016235246B2/en active Active
- 2016-03-23 SG SG11201707527YA patent/SG11201707527YA/en unknown
- 2016-03-23 NZ NZ735093A patent/NZ735093A/en unknown
- 2016-03-23 PL PL16717211T patent/PL3274340T3/pl unknown
- 2016-03-23 CA CA2979555A patent/CA2979555C/en active Active
- 2016-03-23 ES ES16717211T patent/ES2748974T3/es active Active
- 2016-03-23 EP EP16717211.3A patent/EP3274340B1/en active Active
- 2016-03-23 KR KR1020177030184A patent/KR20170137113A/ko active IP Right Grant
- 2016-03-23 JP JP2018501147A patent/JP6741747B2/ja active Active
- 2016-03-23 US US15/556,653 patent/US10464914B2/en active Active
-
2017
- 2017-08-31 IL IL254243A patent/IL254243B/en active IP Right Grant
- 2017-09-14 PH PH12017501687A patent/PH12017501687A1/en unknown
-
2018
- 2018-03-02 HK HK18103065.4A patent/HK1243703A1/zh unknown
- 2018-07-13 HK HK18109115.1A patent/HK1249514A1/zh unknown
-
2019
- 2019-09-25 US US16/582,468 patent/US10947210B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL254243A0 (en) | 2017-10-31 |
| BR112017020168A2 (pt) | 2018-06-05 |
| PH12017501687A1 (en) | 2018-03-19 |
| EA201792094A1 (ru) | 2018-03-30 |
| US20200255393A1 (en) | 2020-08-13 |
| JP2018512453A (ja) | 2018-05-17 |
| HK1249514A1 (zh) | 2018-11-02 |
| CN107567442A (zh) | 2018-01-09 |
| EP3274340B1 (en) | 2019-07-17 |
| CA2979555A1 (en) | 2016-09-29 |
| TWI731854B (zh) | 2021-07-01 |
| KR20170137113A (ko) | 2017-12-12 |
| US10464914B2 (en) | 2019-11-05 |
| JP6741747B2 (ja) | 2020-08-19 |
| TW201643147A (zh) | 2016-12-16 |
| EP3274340A1 (en) | 2018-01-31 |
| IL254243B (en) | 2020-10-29 |
| PL3274340T3 (pl) | 2020-01-31 |
| NZ735093A (en) | 2022-09-30 |
| CN107567442B (zh) | 2021-05-25 |
| WO2016154241A1 (en) | 2016-09-29 |
| AU2016235246A1 (en) | 2017-09-21 |
| DK3274340T3 (da) | 2019-10-07 |
| MX2017012238A (es) | 2018-02-15 |
| US10947210B2 (en) | 2021-03-16 |
| AU2016235246B2 (en) | 2020-12-10 |
| EA033622B1 (ru) | 2019-11-11 |
| SG11201707527YA (en) | 2017-10-30 |
| US20180050998A1 (en) | 2018-02-22 |
| ES2748974T3 (es) | 2020-03-18 |
| CA2979555C (en) | 2023-12-19 |
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