DK3274340T3 - Hæmmere af hepatitis c-viruspolymerase - Google Patents
Hæmmere af hepatitis c-viruspolymerase Download PDFInfo
- Publication number
- DK3274340T3 DK3274340T3 DK16717211.3T DK16717211T DK3274340T3 DK 3274340 T3 DK3274340 T3 DK 3274340T3 DK 16717211 T DK16717211 T DK 16717211T DK 3274340 T3 DK3274340 T3 DK 3274340T3
- Authority
- DK
- Denmark
- Prior art keywords
- hepatitis
- inhibitors
- virus polymerase
- polymerase
- virus
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562136857P | 2015-03-23 | 2015-03-23 | |
| PCT/US2016/023664 WO2016154241A1 (en) | 2015-03-23 | 2016-03-23 | Inhibitors of hepatitis c virus polymerase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3274340T3 true DK3274340T3 (da) | 2019-10-07 |
Family
ID=55759915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16717211.3T DK3274340T3 (da) | 2015-03-23 | 2016-03-23 | Hæmmere af hepatitis c-viruspolymerase |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10464914B2 (da) |
| EP (1) | EP3274340B1 (da) |
| JP (1) | JP6741747B2 (da) |
| KR (1) | KR20170137113A (da) |
| CN (1) | CN107567442B (da) |
| AU (1) | AU2016235246B2 (da) |
| CA (1) | CA2979555C (da) |
| DK (1) | DK3274340T3 (da) |
| EA (1) | EA033622B1 (da) |
| ES (1) | ES2748974T3 (da) |
| HK (2) | HK1243703A1 (da) |
| IL (1) | IL254243B (da) |
| MX (1) | MX2017012238A (da) |
| NZ (1) | NZ735093A (da) |
| PH (1) | PH12017501687A1 (da) |
| PL (1) | PL3274340T3 (da) |
| SG (1) | SG11201707527YA (da) |
| TW (1) | TWI731854B (da) |
| WO (1) | WO2016154241A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| CA3096916A1 (en) * | 2018-05-09 | 2019-11-14 | Cocrystal Pharma, Inc. | Combination therapy for the treatment of hepatitis c virus |
| CN112745216A (zh) * | 2019-10-30 | 2021-05-04 | 常州锐博生物科技有限公司 | 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法 |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11502816A (ja) | 1995-03-20 | 1999-03-09 | イーライ・リリー・アンド・カンパニー | ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| CN100509797C (zh) | 2001-06-11 | 2009-07-08 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
| WO2002100846A1 (en) | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| DE60221627D1 (de) | 2001-12-21 | 2007-09-20 | Virochem Pharma Inc | Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren |
| HN2003000348A (es) * | 2002-11-01 | 2008-10-14 | Viropharma Inc | Compuestos de benzofurano, composiciones y metodos para tratamiento y profilaxis de infeccion virales de hepatitis c y enfermedades asociadas. |
| PT1569929E (pt) | 2002-12-10 | 2010-06-18 | Virochem Pharma Inc | Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus |
| WO2004052879A1 (en) | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Thiophenederivatives for the treatment of flavivirus infections |
| WO2004052885A1 (en) | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| EP1753750A1 (en) | 2004-05-20 | 2007-02-21 | Sugen, Inc. | Thiophene heteroaryl amines |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| US7569600B2 (en) | 2005-05-13 | 2009-08-04 | Virochem Pharma Inc. | Compounds and methods for the treatment of prevention of Flavivirus infections |
| PE20070814A1 (es) | 2005-12-22 | 2007-08-16 | Smithkline Beecham Corp | Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv) |
| WO2008017688A1 (en) | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| TW200815384A (en) | 2006-08-25 | 2008-04-01 | Viropharma Inc | Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein |
| WO2008043791A2 (en) | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| AP2579A (en) | 2006-11-15 | 2013-01-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| WO2008059042A1 (en) | 2006-11-17 | 2008-05-22 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti viral agents |
| GB0707092D0 (en) | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
| GB0712393D0 (en) | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
| BRPI0907885A2 (pt) | 2008-02-14 | 2015-07-21 | Hoffmann La Roche | Compostos antiviras hetrocíclicos |
| WO2009137500A1 (en) * | 2008-05-05 | 2009-11-12 | Wyeth | 6-substituted benzofuran compounds to treat infection with hepatitis c virus |
| TW201136919A (en) * | 2010-03-02 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | Inhibitors of hepatitis C virus NS5B polymerase |
| WO2011106929A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
| US8324239B2 (en) * | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
| TW201221131A (en) * | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
| WO2012083105A1 (en) | 2010-12-17 | 2012-06-21 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| US9707215B2 (en) | 2012-06-20 | 2017-07-18 | Cocrystal, Discovery, Inc. | Inhibitors of hepatitis C virus polymerase |
| TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
-
2016
- 2016-03-21 TW TW105108618A patent/TWI731854B/zh active
- 2016-03-23 AU AU2016235246A patent/AU2016235246B2/en active Active
- 2016-03-23 SG SG11201707527YA patent/SG11201707527YA/en unknown
- 2016-03-23 CA CA2979555A patent/CA2979555C/en active Active
- 2016-03-23 DK DK16717211.3T patent/DK3274340T3/da active
- 2016-03-23 US US15/556,653 patent/US10464914B2/en active Active
- 2016-03-23 CN CN201680017709.XA patent/CN107567442B/zh active Active
- 2016-03-23 MX MX2017012238A patent/MX2017012238A/es unknown
- 2016-03-23 JP JP2018501147A patent/JP6741747B2/ja active Active
- 2016-03-23 WO PCT/US2016/023664 patent/WO2016154241A1/en active Application Filing
- 2016-03-23 ES ES16717211T patent/ES2748974T3/es active Active
- 2016-03-23 PL PL16717211T patent/PL3274340T3/pl unknown
- 2016-03-23 EA EA201792094A patent/EA033622B1/ru not_active IP Right Cessation
- 2016-03-23 KR KR1020177030184A patent/KR20170137113A/ko active IP Right Grant
- 2016-03-23 NZ NZ735093A patent/NZ735093A/en unknown
- 2016-03-23 EP EP16717211.3A patent/EP3274340B1/en active Active
-
2017
- 2017-08-31 IL IL254243A patent/IL254243B/en active IP Right Grant
- 2017-09-14 PH PH12017501687A patent/PH12017501687A1/en unknown
-
2018
- 2018-03-02 HK HK18103065.4A patent/HK1243703A1/zh unknown
- 2018-07-13 HK HK18109115.1A patent/HK1249514A1/zh unknown
-
2019
- 2019-09-25 US US16/582,468 patent/US10947210B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3274340B1 (en) | 2019-07-17 |
| EP3274340A1 (en) | 2018-01-31 |
| CN107567442B (zh) | 2021-05-25 |
| KR20170137113A (ko) | 2017-12-12 |
| PH12017501687A1 (en) | 2018-03-19 |
| NZ735093A (en) | 2022-09-30 |
| PL3274340T3 (pl) | 2020-01-31 |
| US20180050998A1 (en) | 2018-02-22 |
| CA2979555C (en) | 2023-12-19 |
| HK1243703A1 (zh) | 2018-07-20 |
| EA033622B1 (ru) | 2019-11-11 |
| US20200255393A1 (en) | 2020-08-13 |
| US10464914B2 (en) | 2019-11-05 |
| TW201643147A (zh) | 2016-12-16 |
| US10947210B2 (en) | 2021-03-16 |
| AU2016235246B2 (en) | 2020-12-10 |
| IL254243A0 (en) | 2017-10-31 |
| MX2017012238A (es) | 2018-02-15 |
| ES2748974T3 (es) | 2020-03-18 |
| EA201792094A1 (ru) | 2018-03-30 |
| JP2018512453A (ja) | 2018-05-17 |
| JP6741747B2 (ja) | 2020-08-19 |
| TWI731854B (zh) | 2021-07-01 |
| SG11201707527YA (en) | 2017-10-30 |
| IL254243B (en) | 2020-10-29 |
| CA2979555A1 (en) | 2016-09-29 |
| BR112017020168A2 (pt) | 2018-06-05 |
| WO2016154241A1 (en) | 2016-09-29 |
| AU2016235246A1 (en) | 2017-09-21 |
| CN107567442A (zh) | 2018-01-09 |
| HK1249514A1 (zh) | 2018-11-02 |
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