HK1249514A1 - C型肝炎病毒聚合酶的抑制劑 - Google Patents
C型肝炎病毒聚合酶的抑制劑Info
- Publication number
- HK1249514A1 HK1249514A1 HK18109115.1A HK18109115A HK1249514A1 HK 1249514 A1 HK1249514 A1 HK 1249514A1 HK 18109115 A HK18109115 A HK 18109115A HK 1249514 A1 HK1249514 A1 HK 1249514A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hepatitis
- inhibitors
- virus polymerase
- polymerase
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562136857P | 2015-03-23 | 2015-03-23 | |
PCT/US2016/023664 WO2016154241A1 (en) | 2015-03-23 | 2016-03-23 | Inhibitors of hepatitis c virus polymerase |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1249514A1 true HK1249514A1 (zh) | 2018-11-02 |
Family
ID=55759915
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103065.4A HK1243703A1 (zh) | 2015-03-23 | 2018-03-02 | C型肝炎病毒聚合酶的抑制劑 |
HK18109115.1A HK1249514A1 (zh) | 2015-03-23 | 2018-07-13 | C型肝炎病毒聚合酶的抑制劑 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103065.4A HK1243703A1 (zh) | 2015-03-23 | 2018-03-02 | C型肝炎病毒聚合酶的抑制劑 |
Country Status (19)
Country | Link |
---|---|
US (2) | US10464914B2 (zh) |
EP (1) | EP3274340B1 (zh) |
JP (1) | JP6741747B2 (zh) |
KR (1) | KR20170137113A (zh) |
CN (1) | CN107567442B (zh) |
AU (1) | AU2016235246B2 (zh) |
CA (1) | CA2979555C (zh) |
DK (1) | DK3274340T3 (zh) |
EA (1) | EA033622B1 (zh) |
ES (1) | ES2748974T3 (zh) |
HK (2) | HK1243703A1 (zh) |
IL (1) | IL254243B (zh) |
MX (1) | MX2017012238A (zh) |
NZ (1) | NZ735093A (zh) |
PH (1) | PH12017501687A1 (zh) |
PL (1) | PL3274340T3 (zh) |
SG (1) | SG11201707527YA (zh) |
TW (1) | TWI731854B (zh) |
WO (1) | WO2016154241A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | C型肝炎病毒聚合酶之抑制劑 |
CA3096916A1 (en) * | 2018-05-09 | 2019-11-14 | Cocrystal Pharma, Inc. | Combination therapy for the treatment of hepatitis c virus |
CN112745216A (zh) * | 2019-10-30 | 2021-05-04 | 常州锐博生物科技有限公司 | 一种4-溴甲基苯甲酸甲酯及其衍生物的制备方法 |
CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2215322A1 (en) | 1995-03-20 | 1996-09-26 | Stephen Warren Kaldor | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
EP1395571A1 (en) | 2001-06-11 | 2004-03-10 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
PL395097A1 (pl) | 2001-06-11 | 2011-10-10 | Vertex Pharmaceuticals (Canada) Incorporated | Sposób wytwarzania związku o wzorze A stanowiącego pochodną tiofenu |
EP1321463B1 (en) | 2001-12-21 | 2007-08-08 | Virochem Pharma Inc. | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections |
WO2004041201A2 (en) * | 2002-11-01 | 2004-05-21 | Viropharma Incorporated | Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases |
PT1569929E (pt) | 2002-12-10 | 2010-06-18 | Virochem Pharma Inc | Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus |
AU2003291886A1 (en) | 2002-12-10 | 2004-06-30 | Virochem Pharma Inc. | Thiophenederivatives for the treatment of flavivirus infections |
ATE466856T1 (de) | 2002-12-10 | 2010-05-15 | Virochem Pharma Inc | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
US20070293484A1 (en) | 2004-05-20 | 2007-12-20 | Sugen, Inc. | Thiophene Heteroaryl Amines |
DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
CA2607359C (en) | 2005-05-13 | 2011-08-09 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
US20090136448A1 (en) | 2005-12-22 | 2009-05-28 | John Andrew Corfield | Antiviral 2-Carboxy-Thiophene Compounds |
WO2008017688A1 (en) | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
TW200815384A (en) | 2006-08-25 | 2008-04-01 | Viropharma Inc | Combination therapy method for treating hepatitis C virus infection and pharmaceutical compositions for use therein |
WO2008043791A2 (en) | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
RS52874B (en) | 2006-11-15 | 2013-12-31 | Vertex Pharmaceuticals Incorporated | THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS |
US20090274655A1 (en) | 2006-11-17 | 2009-11-05 | Richard Martin Grimes | 2-carboxy thiophene derivatives as anti viral agents |
GB0707092D0 (en) | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
GB0712393D0 (en) | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
GB0718435D0 (en) * | 2007-09-21 | 2007-10-31 | Northern Health And Social Car | Wpund care formulation |
ATE539070T1 (de) | 2008-02-14 | 2012-01-15 | Hoffmann La Roche | Heterozyklische antivirale verbindungen |
WO2009137500A1 (en) * | 2008-05-05 | 2009-11-12 | Wyeth | 6-substituted benzofuran compounds to treat infection with hepatitis c virus |
WO2011106929A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
AR080433A1 (es) * | 2010-03-02 | 2012-04-11 | Merck Sharp & Dohme | Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen. |
AR082453A1 (es) * | 2010-04-21 | 2012-12-12 | Novartis Ag | Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos |
WO2012067663A1 (en) * | 2010-11-18 | 2012-05-24 | Glaxo Group Limited | Compounds |
US8771665B2 (en) | 2010-12-17 | 2014-07-08 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis C virus polymerase |
WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
TWI731854B (zh) * | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | C型肝炎病毒聚合酶之抑制劑 |
-
2016
- 2016-03-21 TW TW105108618A patent/TWI731854B/zh active
- 2016-03-23 WO PCT/US2016/023664 patent/WO2016154241A1/en active Application Filing
- 2016-03-23 JP JP2018501147A patent/JP6741747B2/ja active Active
- 2016-03-23 SG SG11201707527YA patent/SG11201707527YA/en unknown
- 2016-03-23 EP EP16717211.3A patent/EP3274340B1/en active Active
- 2016-03-23 MX MX2017012238A patent/MX2017012238A/es unknown
- 2016-03-23 ES ES16717211T patent/ES2748974T3/es active Active
- 2016-03-23 EA EA201792094A patent/EA033622B1/ru not_active IP Right Cessation
- 2016-03-23 NZ NZ735093A patent/NZ735093A/en unknown
- 2016-03-23 DK DK16717211.3T patent/DK3274340T3/da active
- 2016-03-23 CA CA2979555A patent/CA2979555C/en active Active
- 2016-03-23 US US15/556,653 patent/US10464914B2/en active Active
- 2016-03-23 AU AU2016235246A patent/AU2016235246B2/en active Active
- 2016-03-23 PL PL16717211T patent/PL3274340T3/pl unknown
- 2016-03-23 CN CN201680017709.XA patent/CN107567442B/zh active Active
- 2016-03-23 KR KR1020177030184A patent/KR20170137113A/ko active IP Right Grant
-
2017
- 2017-08-31 IL IL254243A patent/IL254243B/en active IP Right Grant
- 2017-09-14 PH PH12017501687A patent/PH12017501687A1/en unknown
-
2018
- 2018-03-02 HK HK18103065.4A patent/HK1243703A1/zh unknown
- 2018-07-13 HK HK18109115.1A patent/HK1249514A1/zh unknown
-
2019
- 2019-09-25 US US16/582,468 patent/US10947210B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN107567442A (zh) | 2018-01-09 |
US20180050998A1 (en) | 2018-02-22 |
EA033622B1 (ru) | 2019-11-11 |
US20200255393A1 (en) | 2020-08-13 |
EP3274340A1 (en) | 2018-01-31 |
PL3274340T3 (pl) | 2020-01-31 |
TWI731854B (zh) | 2021-07-01 |
US10947210B2 (en) | 2021-03-16 |
EP3274340B1 (en) | 2019-07-17 |
HK1243703A1 (zh) | 2018-07-20 |
JP6741747B2 (ja) | 2020-08-19 |
IL254243B (en) | 2020-10-29 |
BR112017020168A2 (pt) | 2018-06-05 |
US10464914B2 (en) | 2019-11-05 |
AU2016235246A1 (en) | 2017-09-21 |
CA2979555C (en) | 2023-12-19 |
CN107567442B (zh) | 2021-05-25 |
CA2979555A1 (en) | 2016-09-29 |
ES2748974T3 (es) | 2020-03-18 |
SG11201707527YA (en) | 2017-10-30 |
IL254243A0 (en) | 2017-10-31 |
WO2016154241A1 (en) | 2016-09-29 |
MX2017012238A (es) | 2018-02-15 |
JP2018512453A (ja) | 2018-05-17 |
KR20170137113A (ko) | 2017-12-12 |
NZ735093A (en) | 2022-09-30 |
TW201643147A (zh) | 2016-12-16 |
EA201792094A1 (ru) | 2018-03-30 |
PH12017501687A1 (en) | 2018-03-19 |
DK3274340T3 (da) | 2019-10-07 |
AU2016235246B2 (en) | 2020-12-10 |
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